| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 9 | Isiah Kiner-Falefa | 26 | SS | R | 93 | 158 | 635 | 74 | 172 | 25 | 3 | 8 | 53 | 20 | 5 | 28 | 90 | 11 | 1 | 2 | 2 | 11 | 227 | 677 | 36 | 136 | .271 | .312 | .357 | .669 | .154 | .086 | .304 | 4.14 | 13.29 | 3.21 | 79.38 | 2013- 4- 130-TEX | premium | premium | premium | MLB | 2018-2025 | 2013-2025 | 2021 |
| 53 | Adolis Garcia | 28 | CF-RF | R | 101 | 149 | 581 | 77 | 141 | 26 | 2 | 31 | 90 | 16 | 5 | 32 | 194 | 5 | 0 | 4 | 0 | 15 | 264 | 622 | 59 | 82 | .243 | .286 | .454 | .740 | .286 | .211 | .306 | 5.14 | 31.19 | 6.06 | 18.74 | 2017- UDFA -SLN | premium | premium | premium | MLB | 2018-2025 | 2016-2025 | 2021 |
| 30 | Nathaniel Lowe | 25 | 1B | L | 107 | 157 | 557 | 75 | 147 | 24 | 3 | 18 | 72 | 8 | 0 | 80 | 162 | 2 | 0 | 3 | 2 | 13 | 231 | 642 | 45 | 102 | .264 | .357 | .415 | .772 | .309 | .151 | .339 | 12.46 | 25.23 | 2.03 | 30.94 | 2016- 13- 390-TBA | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| 15 | Nick Solak | 26 | 2B | R | 94 | 127 | 458 | 57 | 111 | 18 | 2 | 11 | 49 | 7 | 5 | 34 | 107 | 15 | 2 | 2 | 0 | 11 | 166 | 511 | 31 | 80 | .242 | .314 | .362 | .676 | .199 | .120 | .292 | 6.65 | 20.94 | 3.15 | 41.64 | 2016- 2- 62-NYA | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| 13 | Joey Gallo | 27 | RF | L | 111 | 95 | 310 | 57 | 69 | 6 | 1 | 25 | 55 | 6 | 0 | 74 | 125 | 4 | 0 | 0 | 4 | 3 | 152 | 388 | 32 | 37 | .223 | .379 | .490 | .869 | .526 | .267 | .275 | 19.07 | 32.22 | 1.69 | 12.40 | 2012- 1- 39-TEX | premium | premium | premium | MLB | 2015-2024 | 2012-2024 | 2021 |
| 23 | Jose Trevino | 28 | C | R | 83 | 89 | 285 | 23 | 68 | 14 | 0 | 5 | 30 | 1 | 1 | 12 | 57 | 0 | 2 | 3 | 1 | 13 | 97 | 302 | 19 | 49 | .239 | .267 | .340 | .607 | .144 | .101 | .279 | 3.97 | 18.87 | 4.75 | 57.00 | 2014- 6- 186-TEX | premium | premium | premium | MLB | 2018-2025 | 2012-2025 | 2021 |
| 28 | Jonah Heim | 26 | C | B | 82 | 82 | 265 | 22 | 52 | 13 | 0 | 10 | 32 | 3 | 1 | 15 | 58 | 1 | 1 | 3 | 0 | 8 | 95 | 285 | 23 | 29 | .196 | .239 | .358 | .597 | .226 | .162 | .210 | 5.26 | 20.35 | 3.87 | 26.50 | 2013- 4- 129-BAL | premium | premium | premium | MLB | 2020-2025 | 2013-2025 | 2021 |
| 5 | Willie Calhoun | 26 | LF-DH | L | 95 | 75 | 260 | 26 | 65 | 10 | 3 | 6 | 25 | 0 | 2 | 21 | 34 | 2 | 0 | 1 | 0 | 6 | 99 | 284 | 19 | 46 | .250 | .310 | .381 | .691 | .204 | .131 | .267 | 7.39 | 11.97 | 1.62 | 43.33 | 2015- 4- 132-LAN | premium | premium | premium | MLB | 2017-2024 | 2014-2025 | 2021 |
| 77 | Andy Ibanez | 28 | 2B-DH | R | 103 | 76 | 253 | 31 | 70 | 15 | 2 | 7 | 25 | 0 | 0 | 15 | 35 | 2 | 1 | 1 | 0 | 6 | 110 | 272 | 24 | 46 | .277 | .321 | .435 | .756 | .217 | .158 | .297 | 5.51 | 12.87 | 2.33 | 36.14 | 2015- UDFA -TEX | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 2 | Charlie Culberson | 32 | 3B | R | 94 | 90 | 247 | 23 | 60 | 15 | 2 | 5 | 22 | 7 | 1 | 17 | 64 | 2 | 4 | 1 | 1 | 3 | 94 | 271 | 22 | 38 | .243 | .296 | .381 | .677 | .231 | .138 | .307 | 6.27 | 23.62 | 3.76 | 49.40 | 2007- 1- 51-SFN | premium | premium | premium | MLB | 2012-2023 | 2007-2023 | 2021 |
| 16 | Brock Holt | 33 | 3B | L | 83 | 76 | 235 | 21 | 49 | 13 | 1 | 2 | 23 | 5 | 1 | 23 | 49 | 1 | 0 | 1 | 0 | 5 | 70 | 260 | 16 | 33 | .209 | .281 | .298 | .579 | .204 | .089 | .254 | 8.85 | 18.85 | 2.13 | 117.50 | 2009- 9- 265-PIT | premium | premium | premium | MLB | 2012-2021 | 2009-2021 | 2021 |
| 21 | David Dahl | 27 | LF-DH | L | 78 | 63 | 205 | 19 | 43 | 11 | 0 | 4 | 18 | 2 | 1 | 10 | 59 | 1 | 1 | 3 | 0 | 3 | 66 | 220 | 15 | 28 | .210 | .247 | .322 | .569 | .166 | .112 | .269 | 4.55 | 26.82 | 5.90 | 51.25 | 2012- 1- 10-COL | premium | premium | premium | MLB | 2016-2024 | 2012-2024 | 2021 |
| 41 | Eli White | 27 | LF-CF | R | 80 | 64 | 198 | 26 | 35 | 6 | 1 | 6 | 15 | 4 | 3 | 18 | 66 | 4 | 0 | 0 | 0 | 2 | 61 | 220 | 13 | 22 | .177 | .259 | .308 | .567 | .227 | .131 | .230 | 8.18 | 30.00 | 3.67 | 33.00 | 2016- 11- 322-OAK | premium | premium | premium | MLB | 2020-2025 | 2014-2025 | 2021 |
| 38 | DJ Peters | 25 | LF-CF | R | 88 | 52 | 197 | 24 | 39 | 7 | 1 | 12 | 34 | 2 | 0 | 4 | 68 | 2 | 0 | 3 | 0 | 4 | 84 | 206 | 20 | 19 | .198 | .218 | .426 | .644 | .259 | .228 | .225 | 1.94 | 33.01 | 17.00 | 16.42 | 2016- 4- 131-LAN | premium | premium | premium | MLB | 2021-2021 | 2015-2024 | 2021 |
| 3 | Leody Taveras | 22 | CF | B | 69* | 49 | 174 | 14 | 28 | 6 | 2 | 3 | 9 | 10 | 1 | 9 | 60 | 1 | 1 | 0 | 0 | 3 | 47 | 185 | 11 | 17 | .161 | .207 | .270 | .477 | .213 | .109 | .225 | 4.86 | 32.43 | 6.67 | 58.00 | 2015- UDFA -TEX | premium | premium | premium | MLB | 2020-2025 | 2016-2025 | 2021 |
| 50 | Jason Martin | 25 | LF | L | 83* | 58 | 144 | 14 | 30 | 3 | 0 | 6 | 17 | 3 | 1 | 8 | 41 | 0 | 1 | 1 | 0 | 1 | 51 | 154 | 9 | 21 | .208 | .248 | .354 | .602 | .215 | .146 | .245 | 5.19 | 26.62 | 5.13 | 24.00 | 2013- 8- 227-HOU | premium | premium | premium | MLB | 2019-2021 | 2013-2024 | 2021 |
| 65 | Yonny Hernandez | 23 | 3B | B | 86* | 43 | 143 | 15 | 31 | 5 | 0 | 0 | 6 | 11 | 2 | 17 | 32 | 4 | 1 | 1 | 0 | 2 | 36 | 166 | 5 | 26 | .217 | .315 | .252 | .567 | .217 | .035 | .277 | 10.24 | 19.28 | 1.88 | 0.00 | 2014- UDFA -TEX | premium | premium | premium | MLB | 2021-2023 | 2015-2025 | 2021 |
| 37 | Yohel Pozo | 24 | DH | R | 21 | 74 | 8 | 21 | 4 | 0 | 1 | 9 | 0 | 0 | 3 | 10 | 0 | 0 | 0 | 0 | 1 | 28 | 77 | 5 | 16 | .284 | .312 | .378 | .690 | .135 | .094 | .317 | 3.90 | 12.99 | 3.33 | 74.00 | 2013- UDFA -TEX | premium | premium | premium | MLB | 2021-2025 | 2014-2025 | 2021 | |
| 4 | Khris Davis | 33 | DH | R | 87* | 22 | 51 | 8 | 8 | 1 | 1 | 2 | 5 | 0 | 0 | 8 | 16 | 0 | 0 | 2 | 0 | 2 | 17 | 61 | 4 | 4 | .157 | .262 | .333 | .595 | .333 | .176 | .171 | 13.11 | 26.23 | 2.00 | 25.50 | 2009- 7- 226-MIL | premium | premium | premium | MLB | 2013-2021 | 2007-2022 | 2021 |
| 83 | Curtis Terry | 24 | DH | R | 13 | 45 | 3 | 4 | 2 | 0 | 0 | 1 | 0 | 0 | 2 | 15 | 1 | 0 | 0 | 0 | 0 | 6 | 48 | 2 | 2 | .089 | .146 | .133 | .279 | .089 | .044 | .133 | 4.17 | 31.25 | 7.50 | 0.00 | 2015- 13- 378-TEX | premium | premium | premium | MLB | 2021-2021 | 2015-2025 | 2021 | |
| 6 | John Hicks | 31 | C | R | 10 | 31 | 6 | 8 | 1 | 0 | 4 | 7 | 0 | 0 | 0 | 8 | 0 | 0 | 0 | 0 | 1 | 21 | 31 | 5 | 3 | .258 | .258 | .677 | .935 | .419 | .419 | .211 | 0.00 | 25.81 | 0.00 | 7.75 | 2011- 4- 123-SEA | premium | premium | premium | MLB | 2015-2021 | 2009-2023 | 2021 | |
| 11 | Ronald Guzman | 26 | 1B-LF | L | 7 | 16 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 4 | 17 | 1 | 0 | .063 | .118 | .250 | .368 | .250 | .187 | .000 | 5.88 | 35.29 | 6.00 | 16.00 | 2011- UDFA -TEX | premium | premium | premium | MLB | 2018-2022 | 2012-2025 | 2021 | |
| 19 | Anderson Tejeda | 23 | 3B | B | 5 | 16 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 17 | 0 | 1 | .063 | .118 | .063 | .181 | .125 | .000 | .167 | 5.88 | 58.82 | 10.00 | 0.00 | 2014- UDFA -TEX | premium | premium | premium | MLB | 2020-2021 | 2015-2021 | 2021 | |
| 24 | Jordan Lyles | 30 | P | R | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 83.33 | 0.00 | 0.00 | 2008- 1- 38-HOU | premium | premium | premium | MLB | 2011-2024 | 2008-2024 | 2021 | |
| 74 | Ryan Dorow | 25 | 3B | R | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | .000 | .143 | .000 | .143 | .167 | .000 | .000 | 14.29 | 42.86 | 3.00 | 0.00 | 2017- 30- 914-TEX | premium | premium | premium | MLB | 2021-2021 | 2017-2022 | 2021 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 33 | Dane Dunning | 26 | P | R | 2 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 0 | 1 | .333 | .333 | .333 | .666 | .000 | .000 | .500 | 0.00 | 25.00 | 0.00 | 0.00 | 2016- 1- 29-WAS | premium | premium | premium | MLB | 2020-2025 | 2014-2025 | 2021 | |
| 39 | Kolby Allard | 23 | P | L | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2015- 1- 14-ATL | premium | premium | premium | MLB | 2018-2025 | 2015-2025 | 2021 | |
| 35 | Kohei Arihara | 28 | P | R | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2020- UDFA -TEX | premium | premium | premium | MLB | 2021-2022 | 2015-2025 | 2021 | |
| 20 | Mike Foltynewicz | 29 | P | R | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2010- 1- 19-HOU | premium | premium | premium | MLB | 2014-2021 | 2010-2021 | 2021 | |
| 44 | Kyle Gibson | 33 | P | R | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2009- 1- 22-MIN | premium | premium | premium | MLB | 2013-2025 | 2007-2025 | 2021 | |
| 66 | Josh Sborz | 27 | P | R | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2015- 2- 74-LAN | premium | premium | premium | MLB | 2019-2024 | 2013-2025 | 2021 | |
| 60 | John King | 26 | P | L | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2017- 10- 314-TEX | premium | premium | premium | MLB | 2020-2025 | 2014-2025 | 2021 | |
| Totals: | 1602 | 5405 | 625 | 1254 | 225 | 24 | 167 | 598 | 106 | 29 | 433 | 1381 | 58 | 16 | 31 | 10 | 113 | 2028 | 5943 | 416 | 838 | .232 | .294 | .375 | .670 | .238 | .143 | .280 | 7.29 | 23.24 | 3.19 | 32.37 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 59 | Brett Martin | 26 | L | 4 | 4 | 3.18 | 66 | 0 | 0 | 0 | 66 | 24 | 0 | 62.1 | 67 | 31 | 22 | 5 | 14 | 42 | 4 | 0 | 0 | 1.30 | 9.67 | 0.72 | 2.02 | 6.06 | 4.48 | 3.00 | 2014- 4- 126-TEX | premium | premium | premium | MLB | 2019-2022 | 2014-2022 | 2021 |
| 66 | Josh Sborz | 27 | R | 4 | 3 | 3.97 | 63 | 0 | 0 | 0 | 63 | 16 | 1 | 59.0 | 52 | 29 | 26 | 7 | 32 | 69 | 8 | 0 | 0 | 1.42 | 7.93 | 1.07 | 4.88 | 10.53 | 4.42 | 2.16 | 2015- 2- 74-LAN | premium | premium | premium | MLB | 2019-2024 | 2013-2025 | 2021 |
| 47 | Hunter Wood | 27 | R | 0 | 0 | 3.60 | 5 | 0 | 0 | 0 | 5 | 1 | 0 | 5.0 | 2 | 2 | 2 | 1 | 2 | 5 | 1 | 0 | 0 | 0.80 | 3.60 | 1.80 | 3.60 | 9.00 | 3.60 | 2.50 | 2013- 29- 878-TBA | premium | premium | premium | MLB | 2017-2021 | 2013-2022 | 2021 |
| 60 | John King | 26 | L | 7 | 5 | 3.52 | 27 | 0 | 0 | 0 | 27 | 6 | 0 | 46.0 | 41 | 24 | 18 | 3 | 12 | 40 | 2 | 0 | 4 | 1.15 | 8.02 | 0.59 | 2.35 | 7.83 | 4.70 | 3.33 | 2017- 10- 314-TEX | premium | premium | premium | MLB | 2020-2025 | 2014-2025 | 2021 |
| 61 | Spencer Patton | 33 | R | 2 | 2 | 3.83 | 42 | 0 | 0 | 0 | 42 | 13 | 2 | 42.1 | 36 | 20 | 18 | 4 | 15 | 48 | 1 | 0 | 0 | 1.20 | 7.65 | 0.85 | 3.19 | 10.20 | 4.25 | 3.20 | 2011- 24- 726-KCA | premium | premium | premium | MLB | 2014-2023 | 2009-2024 | 2021 |
| 35 | Kohei Arihara | 28 | R | 2 | 4 | 6.64 | 10 | 10 | 0 | 0 | 0 | 0 | 0 | 40.2 | 45 | 31 | 30 | 11 | 13 | 24 | 1 | 0 | 4 | 1.43 | 9.96 | 2.43 | 2.88 | 5.31 | 6.86 | 1.85 | 2020- UDFA -TEX | premium | premium | premium | MLB | 2021-2022 | 2015-2025 | 2021 |
| 73 | Jacob Latz | 25 | L | 0 | 1 | 5.79 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 4.2 | 5 | 3 | 3 | 3 | 0 | 4 | 0 | 0 | 0 | 1.07 | 9.64 | 5.79 | 0.00 | 7.71 | 5.79 | 0.00 | 2017- 5- 164-TEX | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 51 | Matt Bush | 35 | R | 0 | 0 | 6.75 | 4 | 0 | 0 | 0 | 4 | 1 | 0 | 4.0 | 4 | 3 | 3 | 3 | 1 | 5 | 0 | 0 | 0 | 1.25 | 9.00 | 6.75 | 2.25 | 11.25 | 6.75 | 5.00 | 2004- 1- 1-SDN | premium | premium | premium | MLB | 2016-2023 | 2004-2023 | 2021 |
| 45 | Jimmy Herget | 27 | R | 0 | 1 | 9.00 | 4 | 0 | 0 | 0 | 4 | 1 | 0 | 4.0 | 5 | 5 | 4 | 1 | 0 | 2 | 0 | 0 | 1 | 1.25 | 11.25 | 2.25 | 0.00 | 4.50 | 11.25 | 0.00 | 2015- 6- 175-CIN | premium | premium | premium | MLB | 2019-2025 | 2013-2025 | 2021 |
| 56 | Dennis Santana | 25 | R | 2 | 4 | 3.63 | 39 | 0 | 0 | 0 | 39 | 7 | 0 | 39.2 | 30 | 20 | 16 | 4 | 21 | 38 | 2 | 0 | 0 | 1.29 | 6.81 | 0.91 | 4.76 | 8.62 | 4.54 | 1.81 | 2013- UDFA -LAN | premium | premium | premium | MLB | 2018-2025 | 2013-2025 | 2021 |
| 36 | Hyeon-Jong Yang | 33 | L | 0 | 3 | 5.60 | 12 | 4 | 0 | 0 | 8 | 1 | 0 | 35.1 | 42 | 24 | 22 | 9 | 16 | 25 | 2 | 0 | 1 | 1.64 | 10.70 | 2.29 | 4.08 | 6.37 | 6.11 | 1.56 | 2021- UDFA -TEX | premium | premium | premium | MLB | 2021-2021 | 2021-2021 | 2021 |
| 41 | Ian Kennedy | 36 | R | 0 | 0 | 2.51 | 32 | 0 | 0 | 0 | 32 | 25 | 16 | 32.1 | 27 | 9 | 9 | 5 | 7 | 35 | 0 | 0 | 0 | 1.05 | 7.52 | 1.39 | 1.95 | 9.74 | 2.51 | 5.00 | 2006- 1- 21-NYA | premium | premium | premium | MLB | 2007-2023 | 2004-2023 | 2021 |
| 45 | Jharel Cotton | 29 | R | 2 | 0 | 3.52 | 23 | 0 | 0 | 0 | 23 | 5 | 0 | 30.2 | 28 | 12 | 12 | 2 | 15 | 30 | 1 | 0 | 2 | 1.40 | 8.22 | 0.59 | 4.40 | 8.80 | 3.52 | 2.00 | 2012- 20- 626-LAN | premium | premium | premium | MLB | 2016-2022 | 2010-2023 | 2021 |
| 57 | Nick Snyder | 25 | R | 0 | 0 | 4.91 | 4 | 0 | 0 | 0 | 4 | 2 | 0 | 3.2 | 3 | 2 | 2 | 0 | 3 | 1 | 0 | 0 | 0 | 1.64 | 7.36 | 0.00 | 7.36 | 2.45 | 4.91 | 0.33 | 2017- 19- 584-TEX | premium | premium | premium | MLB | 2021-2022 | 2017-2025 | 2021 |
| 68 | Joe Barlow | 25 | R | 0 | 2 | 1.55 | 31 | 0 | 0 | 0 | 31 | 18 | 11 | 29.0 | 12 | 9 | 5 | 2 | 12 | 27 | 1 | 0 | 0 | 0.83 | 3.72 | 0.62 | 3.72 | 8.38 | 2.79 | 2.25 | 2016- 11- 339-TEX | premium | premium | premium | MLB | 2021-2023 | 2015-2025 | 2021 |
| 30 | Joely Rodriguez | 29 | L | 1 | 3 | 5.93 | 31 | 0 | 0 | 0 | 31 | 6 | 1 | 27.1 | 32 | 19 | 18 | 3 | 12 | 30 | 1 | 0 | 0 | 1.61 | 10.54 | 0.99 | 3.95 | 9.88 | 6.26 | 2.50 | 2009- UDFA -PIT | premium | premium | premium | MLB | 2016-2024 | 2010-2024 | 2021 |
| 59 | Brett de Geus | 23 | R | 0 | 0 | 8.44 | 19 | 0 | 0 | 0 | 19 | 7 | 0 | 26.2 | 31 | 25 | 25 | 3 | 13 | 26 | 3 | 0 | 6 | 1.65 | 10.46 | 1.01 | 4.39 | 8.77 | 8.44 | 2.00 | 2017- 33-1000-LAN | premium | premium | premium | MLB | 2021-2025 | 2017-2025 | 2021 |
| 67 | Demarcus Evans | 24 | R | 0 | 2 | 5.13 | 25 | 0 | 0 | 0 | 25 | 3 | 0 | 26.1 | 24 | 16 | 15 | 4 | 16 | 33 | 2 | 0 | 1 | 1.52 | 8.20 | 1.37 | 5.47 | 11.28 | 5.47 | 2.06 | 2015- 25- 738-TEX | premium | premium | premium | MLB | 2020-2021 | 2015-2025 | 2021 |
| 49 | Glenn Otto | 25 | R | 0 | 3 | 9.26 | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 23.1 | 32 | 24 | 24 | 2 | 8 | 28 | 1 | 0 | 2 | 1.71 | 12.34 | 0.77 | 3.09 | 10.80 | 9.26 | 3.50 | 2017- 5- 152-NYA | premium | premium | premium | MLB | 2021-2023 | 2015-2024 | 2021 |
| 62 | A.J. Alexy | 23 | R | 3 | 1 | 4.70 | 5 | 4 | 0 | 0 | 1 | 0 | 0 | 23.0 | 13 | 12 | 12 | 4 | 17 | 17 | 0 | 0 | 1 | 1.30 | 5.09 | 1.57 | 6.65 | 6.65 | 4.70 | 1.00 | 2016- 11- 341-LAN | premium | premium | premium | MLB | 2021-2022 | 2016-2025 | 2021 |
| 63 | Wes Benjamin | 27 | L | 0 | 2 | 8.74 | 13 | 2 | 0 | 0 | 11 | 4 | 0 | 22.2 | 29 | 23 | 22 | 6 | 17 | 19 | 1 | 0 | 0 | 2.03 | 11.51 | 2.38 | 6.75 | 7.54 | 9.13 | 1.12 | 2014- 5- 156-TEX | premium | premium | premium | MLB | 2020-2021 | 2012-2025 | 2021 |
| 58 | Drew Anderson | 27 | R | 1 | 1 | 3.27 | 9 | 1 | 0 | 0 | 8 | 3 | 0 | 22.0 | 20 | 8 | 8 | 1 | 6 | 9 | 1 | 0 | 1 | 1.18 | 8.18 | 0.41 | 2.45 | 3.68 | 3.27 | 1.50 | 2012- 21- 668-PHI | premium | premium | premium | MLB | 2017-2021 | 2012-2024 | 2021 |
| 31 | Spencer Howard | 24 | R | 0 | 3 | 9.70 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 21.1 | 28 | 26 | 23 | 5 | 10 | 21 | 3 | 0 | 0 | 1.78 | 11.81 | 2.11 | 4.22 | 8.86 | 10.97 | 2.10 | 2017- 2- 45-PHI | premium | premium | premium | MLB | 2020-2024 | 2016-2025 | 2021 |
| 2 | Charlie Culberson | 32 | R | 0 | 0 | 0.00 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 2.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 | 9.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2007- 1- 51-SFN | premium | premium | premium | MLB | 2012-2023 | 2007-2023 | 2021 |
| 24 | Jordan Lyles | 30 | R | 10 | 13 | 5.15 | 32 | 30 | 0 | 0 | 2 | 1 | 0 | 180.0 | 194 | 104 | 103 | 38 | 56 | 146 | 9 | 0 | 7 | 1.39 | 9.70 | 1.90 | 2.80 | 7.30 | 5.20 | 2.61 | 2008- 1- 38-HOU | premium | premium | premium | MLB | 2011-2024 | 2008-2024 | 2021 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 20 | Mike Foltynewicz | 29 | R | 2 | 12 | 5.44 | 28 | 24 | 0 | 0 | 4 | 0 | 0 | 139.0 | 139 | 86 | 84 | 35 | 36 | 97 | 2 | 0 | 9 | 1.26 | 9.00 | 2.27 | 2.33 | 6.28 | 5.57 | 2.69 | 2010- 1- 19-HOU | premium | premium | premium | MLB | 2014-2021 | 2010-2021 | 2021 |
| 39 | Kolby Allard | 23 | L | 3 | 12 | 5.41 | 32 | 17 | 0 | 0 | 15 | 3 | 0 | 124.2 | 128 | 80 | 75 | 29 | 31 | 104 | 4 | 0 | 4 | 1.28 | 9.24 | 2.09 | 2.24 | 7.51 | 5.78 | 3.35 | 2015- 1- 14-ATL | premium | premium | premium | MLB | 2018-2025 | 2015-2025 | 2021 |
| 33 | Dane Dunning | 26 | R | 5 | 10 | 4.51 | 27 | 25 | 0 | 0 | 2 | 0 | 0 | 117.2 | 126 | 61 | 59 | 13 | 43 | 114 | 8 | 0 | 7 | 1.44 | 9.64 | 0.99 | 3.29 | 8.72 | 4.67 | 2.65 | 2016- 1- 29-WAS | premium | premium | premium | MLB | 2020-2025 | 2014-2025 | 2021 |
| 44 | Kyle Gibson | 33 | R | 6 | 3 | 2.87 | 19 | 19 | 0 | 0 | 0 | 0 | 0 | 113.0 | 92 | 38 | 36 | 9 | 41 | 94 | 2 | 0 | 5 | 1.18 | 7.33 | 0.72 | 3.27 | 7.49 | 3.03 | 2.29 | 2009- 1- 22-MIN | premium | premium | premium | MLB | 2013-2025 | 2007-2025 | 2021 |
| 54 | Kyle Cody | 26 | R | 0 | 2 | 7.94 | 7 | 0 | 0 | 0 | 7 | 2 | 0 | 11.1 | 16 | 11 | 10 | 3 | 2 | 14 | 1 | 0 | 3 | 1.59 | 12.71 | 2.38 | 1.59 | 11.12 | 8.74 | 7.00 | 2016- 6- 189-TEX | premium | premium | premium | MLB | 2020-2021 | 2013-2024 | 2021 |
| 52 | Taylor Hearn | 26 | L | 6 | 6 | 4.66 | 42 | 11 | 0 | 0 | 31 | 10 | 0 | 104.1 | 96 | 58 | 54 | 17 | 42 | 92 | 6 | 0 | 3 | 1.32 | 8.28 | 1.47 | 3.62 | 7.94 | 5.00 | 2.19 | 2015- 5- 164-WAS | premium | premium | premium | MLB | 2019-2023 | 2013-2025 | 2021 |
| 16 | Brock Holt | 33 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1.0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 | 9.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2009- 9- 265-PIT | premium | premium | premium | MLB | 2012-2021 | 2009-2021 | 2021 |
| Totals: | 60 | 102 | 4.80 | 669 | 162 | 0 | 0 | 162 | 507 | 31 | 1424.1 | 1402 | 815 | 760 | 232 | 513 | 1239 | 67 | 0 | 61 | 1.34 | 8.86 | 1.47 | 3.24 | 7.83 | 5.15 | 2.42 | premium | premium | premium |