Based on available data in TBC database. Not a complete historical listing. The list of entities below is based on the city name and does not consider metropolitan areas or suburbs. It is based solely on the name of the city.
| Jim Bowie | 1B | 6-0 | 205 | L | L | 1965-02-17 | Tokyo,JP | MLB | 1994-1994 | 1986-1997 | 1986- 12- 297-SEA |
| Steve Chitren | P | 6-0 | 180 | R | R | 1967-06-08 | Tokyo,JP | MLB | 1990-1991 | 1986-1995 | 1989- 6- 166-OAK |
| Ryota Igarashi | P | 5-11 | 200 | R | R | 1979-05-28 | Tokyo,JP | MLB | 2010-2012 | 1999-2020 | 2009- UDFA -NYN |
| Tadahito Iguchi | IF | 5-10 | 185 | R | R | 1974-12-04 | Tokyo,JP | MLB | 2005-2008 | 1997-2017 | 2005- UDFA -CHA |
| Kaz Ishii | P | 6-0 | 215 | L | L | 1973-09-09 | Tokyo,JP | MLB | 2002-2005 | 1992-2013 | 2002- UDFA -LAN |
| Hisashi Iwakuma | P | 6-3 | 163 | R | R | 1981-04-12 | Tokyo,JP | MLB | 2012-2017 | 2002-2018 | 2012- UDFA -SEA |
| Masao Kida | P | 6-3 | 210 | R | R | 1968-09-12 | Tokyo,JP | MLB | 1999-2005 | 1988-2012 | 1998- UDFA -DET |
| Daisuke Matsuzaka | P | 6-0 | 185 | R | R | 1980-09-13 | Tokyo,JP | MLB | 2007-2014 | 1999-2021 | 2006- UDFA -BOS |
| Jeff McCurry | P | 6-7 | 210 | R | R | 1970-01-21 | Tokyo,JP | MLB | 1995-1999 | 1991-1999 | 1990- 14- 376-PIT |
| Kazuhito Tadano | P | 6-0 | 180 | R | R | 1980-04-25 | Tokyo,JP | MLB | 2004-2005 | 2003-2014 | 2003- UDFA -CLE |
| Hisanori Takahashi | P | 5-10 | 172 | L | L | 1975-04-22 | Tokyo,JP | MLB | 2010-2013 | 2000-2015 | 2010- UDFA -NYN |
| Shingo Takatsu | P | 6-0 | 180 | R | R | 1968-11-25 | Tokyo,JP | MLB | 2004-2005 | 1991-2009 | 2004- UDFA -CHA |
| 12 record(s) |
All historical Major Leaguers listed as born in this city. Excludes players born in nearby suburbs