| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 15 | Dustin Pedroia | 24 | 2B | R | 116 | 157 | 653 | 118 | 213 | 54 | 2 | 17 | 83 | 20 | 1 | 50 | 52 | 7 | 7 | 9 | 1 | 17 | 322 | 726 | 73 | 140 | .326 | .376 | .493 | .869 | .273 | .167 | .331 | 6.89 | 7.16 | 1.04 | 38.41 | 2004- 2- 65-BOS | premium | premium | premium | MLB | 2006-2019 | 2002-2019 | 2008 |
| 46 | Jacoby Ellsbury | 24 | CF-LF | L | 101 | 145 | 554 | 98 | 155 | 22 | 7 | 9 | 47 | 50 | 11 | 41 | 80 | 7 | 4 | 3 | 2 | 9 | 218 | 609 | 38 | 117 | .280 | .336 | .394 | .730 | .258 | .114 | .312 | 6.73 | 13.14 | 1.95 | 61.56 | 2005- 1- 23-BOS | premium | premium | premium | MLB | 2007-2017 | 2003-2017 | 2008 |
| 20 | Kevin Youkilis | 29 | 1B | R | 123 | 145 | 538 | 91 | 168 | 43 | 4 | 29 | 115 | 3 | 5 | 62 | 108 | 12 | 0 | 9 | 7 | 11 | 306 | 621 | 76 | 92 | .312 | .390 | .569 | .959 | .368 | .257 | .339 | 9.98 | 17.39 | 1.74 | 18.55 | 2001- 8- 243-BOS | premium | premium | premium | MLB | 2004-2013 | 1998-2014 | 2008 |
| 33 | Jason Varitek | 36 | C | B | 91 | 131 | 423 | 37 | 93 | 20 | 0 | 13 | 43 | 0 | 1 | 52 | 122 | 6 | 0 | 2 | 3 | 13 | 152 | 483 | 33 | 60 | .220 | .313 | .359 | .672 | .260 | .139 | .276 | 10.77 | 25.26 | 2.35 | 32.54 | 1994- 1- 14-SEA | premium | premium | premium | MLB | 1997-2011 | 1991-2011 | 2008 |
| 25 | Mike Lowell | 34 | 3B | R | 105 | 113 | 419 | 58 | 115 | 27 | 0 | 17 | 73 | 2 | 2 | 38 | 61 | 5 | 0 | 6 | 2 | 14 | 193 | 468 | 44 | 71 | .274 | .338 | .461 | .799 | .277 | .187 | .282 | 8.12 | 13.03 | 1.61 | 24.65 | 1995- 20- 562-NYA | premium | premium | premium | MLB | 1998-2010 | 1993-2010 | 2008 |
| 34 | David Ortiz | 32 | DH | L | 114 | 109 | 416 | 74 | 110 | 30 | 1 | 23 | 89 | 1 | 0 | 70 | 74 | 1 | 1 | 3 | 12 | 11 | 211 | 491 | 54 | 56 | .264 | .369 | .507 | .876 | .413 | .243 | .270 | 14.26 | 15.07 | 1.06 | 18.09 | 1992- UDFA -SEA | premium | premium | premium | MLB | 1997-2016 | 1994-2016 | 2008 |
| 7 | J.D. Drew | 32 | RF | L | 122 | 109 | 368 | 79 | 103 | 23 | 4 | 19 | 64 | 4 | 1 | 79 | 80 | 4 | 0 | 5 | 5 | 11 | 191 | 456 | 46 | 57 | .280 | .408 | .519 | .927 | .462 | .239 | .307 | 17.32 | 17.54 | 1.01 | 19.37 | 1998- 1- 5-SLN | premium | premium | premium | MLB | 1998-2011 | 1995-2011 | 2008 |
| 24 | Manny Ramirez | 36 | LF | R | 132 | 100 | 365 | 66 | 109 | 22 | 1 | 20 | 68 | 1 | 0 | 52 | 86 | 8 | 0 | 0 | 8 | 12 | 193 | 425 | 43 | 66 | .299 | .398 | .529 | .927 | .375 | .230 | .344 | 12.24 | 20.24 | 1.65 | 18.25 | 1991- 1- 13-CLE | premium | premium | premium | MLB | 1993-2011 | 1991-2014 | 2008 |
| 10 | Coco Crisp | 28 | CF | B | 102 | 118 | 361 | 55 | 102 | 18 | 3 | 7 | 41 | 20 | 7 | 35 | 59 | 1 | 8 | 4 | 0 | 6 | 147 | 409 | 28 | 74 | .283 | .344 | .407 | .751 | .258 | .124 | .318 | 8.56 | 14.43 | 1.69 | 51.57 | 1999- 7- 222-SLN | premium | premium | premium | MLB | 2002-2016 | 1999-2019 | 2008 |
| 23 | Julio Lugo | 32 | SS | R | 96 | 82 | 261 | 27 | 70 | 13 | 0 | 1 | 22 | 12 | 4 | 34 | 51 | 4 | 3 | 5 | 0 | 13 | 86 | 307 | 14 | 56 | .268 | .355 | .330 | .685 | .222 | .062 | .322 | 11.07 | 16.61 | 1.50 | 261.00 | 1994- 43-1193-HOU | premium | premium | premium | MLB | 2000-2011 | 1995-2011 | 2008 |
| 12 | Jed Lowrie | 24 | SS-3B | B | 99 | 81 | 260 | 34 | 67 | 25 | 3 | 2 | 46 | 1 | 0 | 35 | 68 | 1 | 2 | 8 | 0 | 8 | 104 | 306 | 30 | 37 | .258 | .339 | .400 | .739 | .281 | .142 | .328 | 11.44 | 22.22 | 1.94 | 130.00 | 2005- 1- 45-BOS | premium | premium | premium | MLB | 2008-2022 | 2003-2022 | 2008 |
| 22 | Sean Casey | 33 | 1B | L | 104 | 69 | 199 | 14 | 64 | 14 | 0 | 0 | 17 | 1 | 0 | 17 | 25 | 2 | 0 | 0 | 3 | 6 | 78 | 218 | 14 | 50 | .322 | .381 | .392 | .773 | .161 | .070 | .368 | 7.80 | 11.47 | 1.47 | 0.00 | 1995- 2- 53-CLE | premium | premium | premium | MLB | 1997-2008 | 1993-2008 | 2008 |
| 44 | Jason Bay | 29 | LF | R | 118 | 49 | 184 | 39 | 54 | 12 | 2 | 9 | 37 | 3 | 0 | 22 | 51 | 2 | 0 | 3 | 2 | 4 | 97 | 211 | 23 | 31 | .293 | .370 | .527 | .897 | .370 | .234 | .354 | 10.43 | 24.17 | 2.32 | 20.44 | 2000- 22- 645-MON | premium | premium | premium | MLB | 2003-2013 | 1999-2013 | 2008 |
| 13 | Alex Cora | 32 | SS | L | 99* | 75 | 152 | 14 | 41 | 8 | 2 | 0 | 9 | 1 | 1 | 16 | 13 | 9 | 1 | 1 | 1 | 3 | 53 | 179 | 10 | 31 | .270 | .371 | .349 | .720 | .184 | .079 | .293 | 8.94 | 7.26 | 0.81 | 0.00 | 1996- 3- 88-LAN | premium | premium | premium | MLB | 1998-2011 | 1994-2011 | 2008 |
| 36,30 | Kevin Cash | 30 | C | R | 88* | 61 | 142 | 11 | 32 | 7 | 0 | 3 | 15 | 0 | 0 | 18 | 50 | 0 | 0 | 2 | 1 | 6 | 48 | 162 | 10 | 22 | .225 | .309 | .338 | .647 | .239 | .113 | .319 | 11.11 | 30.86 | 2.78 | 47.33 | 1999- UDFA -TOR | premium | premium | premium | MLB | 2002-2010 | 1997-2011 | 2008 |
| 11 | Mark Kotsay | 32 | RF | L | 97 | 22 | 84 | 6 | 19 | 8 | 1 | 0 | 12 | 0 | 1 | 7 | 11 | 0 | 0 | 0 | 1 | 1 | 29 | 91 | 9 | 10 | .226 | .286 | .345 | .631 | .190 | .119 | .260 | 7.69 | 12.09 | 1.57 | 0.00 | 1996- 1- 9-MIA | premium | premium | premium | MLB | 1997-2013 | 1994-2013 | 2008 |
| 44 | Brandon Moss | 24 | RF-LF | L | 96 | 34 | 78 | 7 | 23 | 5 | 1 | 2 | 11 | 1 | 1 | 6 | 25 | 0 | 0 | 2 | 0 | 0 | 36 | 86 | 8 | 15 | .295 | .337 | .462 | .799 | .244 | .167 | .396 | 6.98 | 29.07 | 4.17 | 39.00 | 2002- 8- 238-BOS | premium | premium | premium | MLB | 2007-2017 | 2002-2017 | 2008 |
| 55 | Jeff Bailey | 29 | 1B | R | 27 | 50 | 10 | 14 | 1 | 1 | 2 | 6 | 0 | 0 | 9 | 17 | 0 | 0 | 0 | 1 | 2 | 23 | 59 | 4 | 10 | .280 | .390 | .460 | .850 | .360 | .180 | .387 | 15.25 | 28.81 | 1.89 | 25.00 | 1997- 2- 64-MIA | premium | premium | premium | MLB | 2007-2009 | 1997-2011 | 2008 | |
| 54 | Chris Carter | 25 | LF | L | 9 | 18 | 5 | 6 | 0 | 0 | 0 | 3 | 0 | 0 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 6 | 20 | 0 | 6 | .333 | .400 | .333 | .733 | .111 | .000 | .462 | 10.00 | 25.00 | 2.50 | 0.00 | 2004- 17- 506-ARI | premium | premium | premium | MLB | 2008-2010 | 2002-2014 | 2008 | |
| 30,60 | Jonathan Van Every | 28 | RF | L | 11 | 17 | 0 | 4 | 0 | 1 | 0 | 5 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 6 | 18 | 1 | 3 | .235 | .278 | .353 | .631 | .176 | .118 | .364 | 5.56 | 33.33 | 6.00 | 0.00 | 2000- 29- 876-CLE | premium | premium | premium | MLB | 2008-2010 | 2001-2011 | 2008 | |
| 51 | Gil Velazquez | 28 | 2B-SS | R | 3 | 8 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 8 | 0 | 1 | .125 | .125 | .125 | .250 | .000 | .000 | .125 | 0.00 | 0.00 | 0.00 | 0.00 | 1998- 14- 424-NYN | premium | premium | premium | MLB | 2008-2013 | 1998-2014 | 2008 | |
| 3 | Joe Thurston | 28 | LF | L | 4 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | .000 | .111 | .000 | .111 | .000 | .000 | .000 | 0.00 | 11.11 | 0.00 | 0.00 | 1999- 4- 134-LAN | premium | premium | premium | MLB | 2002-2011 | 1999-2014 | 2008 | |
| 28 | David Ross | 31 | C | R | 97* | 8 | 8 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 1 | 9 | 0 | 1 | .125 | .125 | .125 | .250 | .000 | .000 | .200 | 0.00 | 33.33 | 0.00 | 0.00 | 1998- 7- 216-LAN | premium | premium | premium | MLB | 2002-2016 | 1996-2016 | 2008 |
| 19 | Josh Beckett | 28 | P | R | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 42.86 | 0.00 | 0.00 | 1999- 1- 2-MIA | premium | premium | premium | MLB | 2001-2014 | 2000-2014 | 2008 | |
| 31 | Jon Lester | 24 | P | L | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 40.00 | 0.00 | 0.00 | 2002- 2- 57-BOS | premium | premium | premium | MLB | 2006-2021 | 2002-2021 | 2008 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 68 | George Kottaras | 25 | C | L | 3 | 5 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 1 | 0 | .200 | .200 | .400 | .600 | .200 | .200 | .333 | 0.00 | 40.00 | 0.00 | 0.00 | 2002- 20- 595-SDN | premium | premium | premium | MLB | 2008-2014 | 2003-2016 | 2008 | |
| 63 | Justin Masterson | 23 | P | R | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 80.00 | 0.00 | 0.00 | 2006- 2- 71-BOS | premium | premium | premium | MLB | 2008-2015 | 2006-2017 | 2008 | |
| 49 | Tim Wakefield | 41 | P | R | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 1988- 8- 200-PIT | premium | premium | premium | MLB | 1992-2011 | 1988-2011 | 2008 | |
| 40 | Bartolo Colon | 35 | P | R | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 1993- UDFA -CLE | premium | premium | premium | MLB | 1997-2018 | 1994-2021 | 2008 | |
| 18 | Daisuke Matsuzaka | 27 | P | R | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2006- UDFA -BOS | premium | premium | premium | MLB | 2007-2014 | 1999-2021 | 2008 | |
| 48 | Javier Lopez | 30 | P | L | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 1998- 4- 133-ARI | premium | premium | premium | MLB | 2003-2016 | 1996-2016 | 2008 | |
| 53 | David Aardsma | 26 | P | R | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2003- 1- 22-SFN | premium | premium | premium | MLB | 2004-2015 | 2001-2017 | 2008 | |
| Totals: | 1682 | 5596 | 845 | 1565 | 353 | 33 | 173 | 807 | 120 | 35 | 646 | 1068 | 70 | 28 | 62 | 49 | 147 | 2503 | 6402 | 559 | 1006 | .280 | .358 | .447 | .805 | .298 | .168 | .315 | 10.09 | 16.68 | 1.65 | 32.35 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 63 | Justin Masterson | 23 | R | 6 | 5 | 3.16 | 36 | 9 | 0 | 0 | 27 | 6 | 0 | 88.1 | 68 | 31 | 31 | 10 | 40 | 68 | 1 | 0 | 8 | 1.22 | 6.93 | 1.02 | 4.08 | 6.93 | 3.16 | 1.70 | 2006- 2- 71-BOS | premium | premium | premium | MLB | 2008-2015 | 2006-2017 | 2008 |
| 61 | Clay Buchholz | 23 | R | 2 | 9 | 6.75 | 16 | 15 | 1 | 0 | 1 | 0 | 0 | 76.0 | 93 | 63 | 57 | 11 | 41 | 72 | 2 | 1 | 2 | 1.76 | 11.01 | 1.30 | 4.86 | 8.53 | 7.46 | 1.76 | 2005- 1- 42-BOS | premium | premium | premium | MLB | 2007-2019 | 2004-2019 | 2008 |
| 17 | Manny Delcarmen | 26 | R | 1 | 2 | 3.27 | 73 | 0 | 0 | 0 | 73 | 16 | 2 | 74.1 | 55 | 28 | 27 | 5 | 28 | 72 | 0 | 0 | 3 | 1.12 | 6.66 | 0.61 | 3.39 | 8.72 | 3.39 | 2.57 | 2000- 2- 62-BOS | premium | premium | premium | MLB | 2005-2010 | 2001-2018 | 2008 |
| 58 | Jonathan Papelbon | 27 | R | 5 | 4 | 2.34 | 67 | 0 | 0 | 0 | 67 | 62 | 41 | 69.1 | 58 | 24 | 18 | 4 | 8 | 77 | 2 | 0 | 0 | 0.95 | 7.53 | 0.52 | 1.04 | 10.00 | 3.12 | 9.63 | 2003- 4- 114-BOS | premium | premium | premium | MLB | 2005-2016 | 2001-2016 | 2008 |
| 37 | Hideki Okajima | 32 | L | 3 | 2 | 2.61 | 64 | 0 | 0 | 0 | 64 | 11 | 1 | 62.0 | 49 | 18 | 18 | 6 | 23 | 60 | 2 | 0 | 1 | 1.16 | 7.11 | 0.87 | 3.34 | 8.71 | 2.61 | 2.61 | 2006- UDFA -BOS | premium | premium | premium | MLB | 2007-2013 | 1995-2015 | 2008 |
| 43 | Devern Hansack | 30 | R | 1 | 0 | 4.05 | 4 | 0 | 0 | 0 | 4 | 3 | 0 | 6.2 | 6 | 5 | 3 | 0 | 1 | 5 | 0 | 0 | 0 | 1.05 | 8.10 | 0.00 | 1.35 | 6.75 | 6.75 | 5.00 | 2005- UDFA -HOU | premium | premium | premium | MLB | 2006-2008 | 2002-2009 | 2008 |
| 30 | Bryan Corey | 34 | R | 0 | 0 | 10.50 | 7 | 0 | 0 | 0 | 7 | 2 | 0 | 6.0 | 11 | 7 | 7 | 1 | 3 | 4 | 0 | 0 | 0 | 2.33 | 16.50 | 1.50 | 4.50 | 6.00 | 10.50 | 1.33 | 1993- 12- 333-DET | premium | premium | premium | MLB | 1998-2008 | 1993-2012 | 2008 |
| 48 | Javier Lopez | 30 | L | 2 | 0 | 2.43 | 70 | 0 | 0 | 0 | 70 | 10 | 0 | 59.1 | 53 | 18 | 16 | 4 | 27 | 38 | 1 | 0 | 2 | 1.35 | 8.04 | 0.61 | 4.10 | 5.76 | 2.73 | 1.41 | 1998- 4- 133-ARI | premium | premium | premium | MLB | 2003-2016 | 1996-2016 | 2008 |
| 64 | Michael Bowden | 21 | R | 1 | 0 | 3.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 5.0 | 7 | 2 | 2 | 0 | 1 | 3 | 0 | 0 | 0 | 1.60 | 12.60 | 0.00 | 1.80 | 5.40 | 3.60 | 3.00 | 2005- 1- 47-BOS | premium | premium | premium | MLB | 2008-2013 | 2005-2021 | 2008 |
| 50 | Mike Timlin | 42 | R | 4 | 4 | 5.66 | 47 | 0 | 0 | 0 | 47 | 26 | 1 | 49.1 | 60 | 32 | 31 | 9 | 20 | 32 | 1 | 0 | 1 | 1.62 | 10.95 | 1.64 | 3.65 | 5.84 | 5.84 | 1.60 | 1987- 5- 127-TOR | premium | premium | premium | MLB | 1991-2008 | 1987-2009 | 2008 |
| 36 | Paul Byrd | 37 | R | 4 | 2 | 4.78 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 49.0 | 58 | 26 | 26 | 8 | 10 | 26 | 0 | 0 | 2 | 1.39 | 10.65 | 1.47 | 1.84 | 4.78 | 4.78 | 2.60 | 1991- 4- 112-CLE | premium | premium | premium | MLB | 1995-2009 | 1989-2009 | 2008 |
| 53 | David Aardsma | 26 | R | 4 | 2 | 5.55 | 47 | 0 | 0 | 0 | 47 | 7 | 0 | 48.2 | 49 | 32 | 30 | 4 | 35 | 49 | 3 | 0 | 5 | 1.73 | 9.06 | 0.74 | 6.47 | 9.06 | 5.92 | 1.40 | 2003- 1- 22-SFN | premium | premium | premium | MLB | 2004-2015 | 2001-2017 | 2008 |
| 51 | Charlie Zink | 28 | R | 0 | 0 | 16.62 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 4.1 | 11 | 8 | 8 | 0 | 1 | 1 | 1 | 0 | 0 | 2.77 | 22.85 | 0.00 | 2.08 | 2.08 | 16.62 | 1.00 | 2002- UDFA -BOS | premium | premium | premium | MLB | 2008-2008 | 2001-2011 | 2008 |
| 40 | Bartolo Colon | 35 | R | 4 | 2 | 3.92 | 7 | 7 | 0 | 0 | 0 | 0 | 0 | 39.0 | 44 | 23 | 17 | 5 | 10 | 27 | 0 | 0 | 2 | 1.38 | 10.15 | 1.15 | 2.31 | 6.23 | 5.31 | 2.70 | 1993- UDFA -CLE | premium | premium | premium | MLB | 1997-2018 | 1994-2021 | 2008 |
| 56 | Craig Hansen | 24 | R | 1 | 3 | 5.58 | 32 | 0 | 0 | 0 | 32 | 6 | 2 | 30.2 | 29 | 23 | 19 | 2 | 23 | 25 | 3 | 0 | 1 | 1.70 | 8.51 | 0.59 | 6.75 | 7.34 | 6.75 | 1.09 | 2005- 1- 26-BOS | premium | premium | premium | MLB | 2005-2009 | 2003-2012 | 2008 |
| 31 | Jon Lester | 24 | L | 16 | 6 | 3.21 | 33 | 33 | 2 | 2 | 0 | 0 | 0 | 210.1 | 202 | 78 | 75 | 14 | 66 | 152 | 3 | 1 | 10 | 1.27 | 8.64 | 0.60 | 2.82 | 6.50 | 3.34 | 2.30 | 2002- 2- 57-BOS | premium | premium | premium | MLB | 2006-2021 | 2002-2021 | 2008 |
| 49 | Tim Wakefield | 41 | R | 10 | 11 | 4.13 | 30 | 30 | 1 | 0 | 0 | 0 | 0 | 181.0 | 154 | 89 | 83 | 25 | 60 | 117 | 12 | 0 | 13 | 1.18 | 7.66 | 1.24 | 2.98 | 5.82 | 4.43 | 1.95 | 1988- 8- 200-PIT | premium | premium | premium | MLB | 1992-2011 | 1988-2011 | 2008 |
| 59 | Chris Smith | 27 | R | 1 | 0 | 7.85 | 12 | 0 | 0 | 0 | 12 | 3 | 0 | 18.1 | 18 | 16 | 16 | 6 | 7 | 13 | 0 | 0 | 0 | 1.36 | 8.84 | 2.95 | 3.44 | 6.38 | 7.85 | 1.86 | 2002- 4- 118-BOS | premium | premium | premium | MLB | 2008-2017 | 2000-2017 | 2008 |
| 19 | Josh Beckett | 28 | R | 12 | 10 | 4.03 | 27 | 27 | 1 | 0 | 0 | 0 | 0 | 174.1 | 173 | 80 | 78 | 18 | 34 | 172 | 5 | 0 | 9 | 1.19 | 8.93 | 0.93 | 1.76 | 8.88 | 4.13 | 5.06 | 1999- 1- 2-MIA | premium | premium | premium | MLB | 2001-2014 | 2000-2014 | 2008 |
| 18 | Daisuke Matsuzaka | 27 | R | 18 | 3 | 2.90 | 29 | 29 | 0 | 0 | 0 | 0 | 0 | 167.2 | 128 | 58 | 54 | 12 | 94 | 154 | 5 | 0 | 7 | 1.32 | 6.87 | 0.64 | 5.05 | 8.27 | 3.11 | 1.64 | 2006- UDFA -BOS | premium | premium | premium | MLB | 2007-2014 | 1999-2021 | 2008 |
| 51 | Julian Tavarez | 35 | R | 0 | 1 | 6.39 | 9 | 0 | 0 | 0 | 9 | 2 | 0 | 12.2 | 18 | 12 | 9 | 0 | 9 | 6 | 1 | 0 | 1 | 2.13 | 12.79 | 0.00 | 6.39 | 4.26 | 8.53 | 0.67 | 1990- UDFA -CLE | premium | premium | premium | MLB | 1993-2009 | 1992-2009 | 2008 |
| 62 | David Pauley | 25 | R | 0 | 1 | 11.68 | 6 | 2 | 0 | 0 | 4 | 3 | 0 | 12.1 | 23 | 17 | 16 | 2 | 5 | 11 | 0 | 0 | 1 | 2.27 | 16.78 | 1.46 | 3.65 | 8.03 | 12.41 | 2.20 | 2001- 8- 240-SDN | premium | premium | premium | MLB | 2006-2012 | 2001-2014 | 2008 |
| 39 | Kyle Snyder | 30 | R | 0 | 0 | 21.60 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 1.2 | 2 | 4 | 4 | 1 | 2 | 1 | 1 | 0 | 0 | 2.40 | 10.80 | 5.40 | 10.80 | 5.40 | 21.60 | 0.50 | 1999- 1- 7-KCA | premium | premium | premium | MLB | 2003-2008 | 1997-2011 | 2008 |
| Totals: | 95 | 67 | 4.01 | 628 | 162 | 5 | 2 | 157 | 466 | 47 | 1446.1 | 1369 | 694 | 645 | 147 | 548 | 1185 | 43 | 2 | 68 | 1.33 | 8.52 | 0.91 | 3.41 | 7.37 | 4.32 | 2.16 | premium | premium | premium |