| Central | W | L | Pct | GB |
| Cincinnati | 97 | 65 | .599 | -- |
| St. Louis | 88 | 74 | .543 | 9.0 |
| Milwaukee | 83 | 79 | .512 | 14.0 |
| Pittsburgh | 79 | 83 | .488 | 18.0 |
| Chi Cubs | 61 | 101 | .377 | 36.0 |
| Houston | 55 | 107 | .340 | 42.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-04-05 | Johnny Cueto | R | 26 | L 4-0 | vs MIA | 1 | 117 | W | 7.0 | 3 | 0 | 0 | 0 | 2 | 4 | 93 | 34 | 59 | 63% | 1-0 | 0.00 | 0.71 |
| 2012-04-07 | Mat Latos | R | 24 | W 3-8 | vs MIA | 1 | 73 | L | 4.2 | 7 | 4 | 4 | 1 | 2 | 4 | 80 | 30 | 50 | 63% | 0-1 | 7.20 | 1.80 |
| 2012-04-08 | Bronson Arroyo | R | 35 | L 6-5 | vs MIA | 1 | 292 | - | 6.1 | 10 | 5 | 4 | 0 | 0 | 4 | 82 | 18 | 64 | 78% | 0-0 | 6.00 | 1.67 |
| 2012-04-09 | Homer Bailey | R | 26 | W 1-7 | vs SLN | 1 | 79 | L | 5.2 | 6 | 4 | 4 | 3 | 3 | 5 | 91 | 37 | 54 | 59% | 0-1 | 6.00 | 1.50 |
| 2012-04-10 | Mike Leake | R | 24 | W 1-3 | vs SLN | 1 | 49 | L | 6.0 | 7 | 3 | 3 | 2 | 1 | 4 | 99 | 35 | 64 | 65% | 0-1 | 4.50 | 1.33 |
| 2012-04-11 | Johnny Cueto | R | 26 | L 4-3 | vs SLN | 2 | 118 | - | 5.0 | 7 | 3 | 3 | 1 | 0 | 3 | 90 | 30 | 60 | 67% | 1-0 | 2.25 | 1.00 |
| 2012-04-12 | Mat Latos | R | 24 | L 2-3 | @ WAS | 2 | 74 | - | 5.0 | 5 | 2 | 2 | 0 | 3 | 1 | 99 | 37 | 62 | 63% | 0-1 | 5.40 | 1.70 |
| 2012-04-13 | Bronson Arroyo | R | 35 | L 1-2 | @ WAS | 2 | 293 | - | 7.1 | 3 | 0 | 0 | 0 | 1 | 4 | 93 | 36 | 57 | 61% | 0-0 | 2.57 | 1.00 |
| 2012-04-14 | Homer Bailey | R | 26 | L 1-4 | @ WAS | 2 | 80 | L | 6.0 | 7 | 3 | 3 | 0 | 4 | 3 | 108 | 44 | 64 | 59% | 0-2 | 5.25 | 1.67 |
| 2012-04-15 | Mike Leake | R | 24 | W 8-5 | @ WAS | 2 | 50 | - | 6.1 | 5 | 5 | 5 | 0 | 3 | 1 | 95 | 33 | 62 | 65% | 0-1 | 6.00 | 1.33 |
| 2012-04-17 | Johnny Cueto | R | 26 | L 1-2 | @ SLN | 3 | 119 | - | 7.0 | 7 | 1 | 1 | 1 | 2 | 5 | 111 | 44 | 67 | 60% | 1-0 | 1.89 | 1.11 |
| 2012-04-18 | Mat Latos | R | 24 | L 1-11 | @ SLN | 3 | 75 | L | 5.2 | 9 | 8 | 8 | 1 | 3 | 6 | 124 | 46 | 78 | 63% | 0-2 | 8.40 | 1.93 |
| 2012-04-19 | Bronson Arroyo | R | 35 | W 6-3 | @ SLN | 3 | 294 | W | 8.0 | 5 | 3 | 3 | 1 | 0 | 5 | 90 | 24 | 66 | 73% | 1-0 | 2.86 | 0.86 |
| 2012-04-20 | Homer Bailey | R | 26 | W 9-4 | @ CHN | 3 | 81 | W | 7.0 | 5 | 4 | 1 | 0 | 0 | 2 | 112 | 39 | 73 | 65% | 1-2 | 3.79 | 1.32 |
| 2012-04-21 | Mike Leake | R | 24 | L 1-6 | @ CHN | 3 | 51 | L | 5.2 | 10 | 5 | 5 | 0 | 1 | 3 | 82 | 24 | 58 | 71% | 0-2 | 6.50 | 1.50 |
| 2012-04-22 | Johnny Cueto | R | 26 | W 4-3 | @ CHN | 4 | 120 | W | 6.1 | 5 | 2 | 1 | 0 | 2 | 7 | 114 | 35 | 79 | 69% | 2-0 | 1.80 | 1.12 |
| 2012-04-24 | Mat Latos | R | 24 | L 9-2 | vs SFN | 4 | 76 | W | 7.0 | 4 | 0 | 0 | 0 | 2 | 3 | 95 | 29 | 66 | 69% | 1-2 | 5.73 | 1.59 |
| 2012-04-25 | Bronson Arroyo | R | 35 | L 4-2 | vs SFN | 4 | 295 | - | 5.0 | 9 | 2 | 1 | 1 | 1 | 2 | 80 | 24 | 56 | 70% | 1-0 | 2.67 | 1.07 |
| 2012-04-26 | Homer Bailey | R | 26 | W 5-6 | vs SFN | 4 | 82 | - | 6.1 | 7 | 3 | 2 | 0 | 2 | 6 | 85 | 27 | 58 | 68% | 1-2 | 3.60 | 1.36 |
| 2012-04-27 | Mike Leake | R | 24 | W 4-6 | vs HOU | 4 | 52 | L | 3.2 | 7 | 6 | 3 | 0 | 0 | 1 | 64 | 26 | 38 | 59% | 0-3 | 6.55 | 1.55 |
| 2012-04-28 | Johnny Cueto | R | 26 | L 6-0 | vs HOU | 5 | 121 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 3 | 120 | 42 | 78 | 65% | 3-0 | 1.41 | 1.06 |
| 2012-04-29 | Mat Latos | R | 24 | L 6-5 | vs HOU | 5 | 77 | - | 6.1 | 10 | 5 | 5 | 2 | 0 | 4 | 106 | 39 | 67 | 63% | 1-2 | 5.90 | 1.55 |
| 2012-05-02 | Bronson Arroyo | R | 35 | W 1-3 | vs CHN | 5 | 296 | L | 6.0 | 9 | 3 | 3 | 2 | 1 | 3 | 97 | 31 | 66 | 68% | 1-1 | 3.00 | 1.18 |
| 2012-05-03 | Homer Bailey | R | 26 | L 4-3 | vs CHN | 5 | 83 | - | 6.0 | 9 | 3 | 3 | 3 | 1 | 4 | 97 | 28 | 69 | 71% | 1-2 | 3.77 | 1.42 |
| 2012-05-04 | Johnny Cueto | R | 26 | W 6-1 | @ PIT | 6 | 122 | W | 9.0 | 7 | 1 | 1 | 0 | 0 | 4 | 109 | 35 | 74 | 68% | 4-0 | 1.32 | 1.00 |
| 2012-05-05 | Mike Leake | R | 24 | L 2-3 | @ PIT | 5 | 53 | L | 7.0 | 4 | 3 | 3 | 2 | 4 | 4 | 94 | 35 | 59 | 63% | 0-4 | 5.90 | 1.45 |
| 2012-05-06 | Mat Latos | R | 24 | W 5-0 | @ PIT | 6 | 78 | W | 6.0 | 2 | 0 | 0 | 0 | 3 | 11 | 104 | 39 | 65 | 63% | 2-2 | 4.89 | 1.43 |
| 2012-05-07 | Bronson Arroyo | R | 35 | W 6-1 | @ MIL | 6 | 297 | W | 6.2 | 6 | 1 | 1 | 1 | 1 | 9 | 108 | 37 | 71 | 66% | 2-1 | 2.77 | 1.18 |
| 2012-05-08 | Homer Bailey | R | 26 | L 3-8 | @ MIL | 6 | 84 | L | 3.2 | 6 | 6 | 6 | 0 | 3 | 4 | 89 | 32 | 57 | 64% | 1-3 | 4.89 | 1.51 |
| 2012-05-09 | Johnny Cueto | R | 26 | W 2-1 | @ MIL | 7 | 123 | - | 7.0 | 5 | 0 | 0 | 0 | 1 | 5 | 103 | 43 | 60 | 58% | 4-0 | 1.13 | 0.98 |
| 2012-05-11 | Mike Leake | R | 24 | W 3-7 | vs WAS | 6 | 54 | L | 3.0 | 7 | 6 | 6 | 2 | 2 | 3 | 71 | 28 | 43 | 61% | 0-5 | 7.03 | 1.59 |
| 2012-05-12 | Mat Latos | R | 24 | W 1-2 | vs WAS | 7 | 79 | - | 5.0 | 3 | 1 | 1 | 1 | 5 | 4 | 107 | 50 | 57 | 53% | 2-2 | 4.50 | 1.45 |
| 2012-05-13 | Bronson Arroyo | R | 35 | L 9-6 | vs WAS | 7 | 298 | - | 5.0 | 11 | 4 | 4 | 0 | 1 | 6 | 91 | 26 | 65 | 71% | 2-1 | 3.27 | 1.32 |
| 2012-05-14 | Homer Bailey | R | 26 | W 3-1 | @ ATL | 7 | 85 | - | 6.2 | 6 | 1 | 1 | 0 | 2 | 3 | 114 | 46 | 68 | 60% | 1-3 | 4.39 | 1.49 |
| 2012-05-15 | Johnny Cueto | R | 26 | L 2-6 | @ ATL | 8 | 124 | L | 4.0 | 8 | 6 | 5 | 1 | 2 | 2 | 83 | 32 | 51 | 61% | 4-1 | 1.90 | 1.10 |
| 2012-05-16 | Mike Leake | R | 25 | W 6-3 | @ NYN | 7 | 55 | - | 6.0 | 7 | 3 | 1 | 0 | 2 | 5 | 111 | 46 | 65 | 59% | 0-5 | 6.16 | 1.58 |
| 2012-05-17 | Mat Latos | R | 24 | L 4-9 | @ NYN | 8 | 80 | - | 5.0 | 7 | 3 | 3 | 0 | 3 | 7 | 108 | 40 | 68 | 63% | 2-2 | 4.60 | 1.51 |
| 2012-05-18 | Bronson Arroyo | R | 35 | L 0-4 | @ NYA | 8 | 299 | L | 7.2 | 9 | 4 | 4 | 2 | 1 | 4 | 101 | 41 | 60 | 59% | 2-2 | 3.46 | 1.31 |
| 2012-05-19 | Homer Bailey | R | 26 | W 6-5 | @ NYA | 8 | 86 | W | 6.1 | 7 | 3 | 3 | 2 | 1 | 7 | 99 | 31 | 68 | 69% | 2-3 | 4.31 | 1.44 |
| 2012-05-20 | Johnny Cueto | R | 26 | W 5-2 | @ NYA | 9 | 125 | W | 7.0 | 8 | 2 | 2 | 1 | 2 | 5 | 107 | 42 | 65 | 61% | 5-1 | 1.98 | 1.14 |
| 2012-05-21 | Mike Leake | R | 25 | L 4-1 | vs ATL | 8 | 56 | W | 8.0 | 3 | 1 | 1 | 1 | 1 | 6 | 94 | 30 | 64 | 68% | 1-5 | 5.28 | 1.39 |
| 2012-05-22 | Mat Latos | R | 24 | L 4-3 | vs ATL | 9 | 81 | W | 7.0 | 5 | 2 | 2 | 1 | 1 | 8 | 115 | 37 | 78 | 68% | 3-2 | 4.33 | 1.42 |
| 2012-05-23 | Bronson Arroyo | R | 35 | L 2-1 | vs ATL | 9 | 300 | - | 6.2 | 4 | 1 | 1 | 1 | 2 | 7 | 107 | 41 | 66 | 62% | 2-2 | 3.20 | 1.25 |
| 2012-05-24 | Homer Bailey | R | 26 | L 6-3 | vs ATL | 9 | 87 | W | 6.0 | 4 | 2 | 2 | 1 | 1 | 6 | 98 | 37 | 61 | 62% | 3-3 | 4.17 | 1.37 |
| 2012-05-25 | Johnny Cueto | R | 26 | W 3-6 | vs COL | 10 | 126 | L | 4.2 | 11 | 5 | 5 | 1 | 2 | 3 | 93 | 36 | 57 | 61% | 5-2 | 2.53 | 1.25 |
| 2012-05-26 | Mike Leake | R | 25 | L 10-3 | vs COL | 9 | 57 | - | 3.2 | 9 | 3 | 3 | 0 | 1 | 4 | 82 | 31 | 51 | 62% | 1-5 | 5.51 | 1.51 |
| 2012-05-27 | Mat Latos | R | 24 | L 7-5 | vs COL | 10 | 82 | W | 7.1 | 5 | 5 | 5 | 5 | 0 | 3 | 96 | 31 | 65 | 68% | 4-2 | 4.58 | 1.34 |
| 2012-05-28 | Bronson Arroyo | R | 35 | L 1-4 | @ PIT | 10 | 301 | L | 4.0 | 8 | 4 | 4 | 0 | 1 | 1 | 81 | 26 | 55 | 68% | 2-3 | 3.57 | 1.32 |
| 2012-05-29 | Homer Bailey | R | 26 | W 8-1 | @ PIT | 10 | 88 | W | 9.0 | 4 | 1 | 1 | 0 | 1 | 5 | 104 | 27 | 77 | 74% | 4-3 | 3.71 | 1.25 |
| 2012-05-30 | Johnny Cueto | R | 26 | L 1-2 | @ PIT | 11 | 127 | L | 7.0 | 5 | 2 | 2 | 0 | 4 | 5 | 103 | 42 | 61 | 59% | 5-3 | 2.54 | 1.25 |
| 2012-06-01 | Mike Leake | R | 25 | W 4-1 | @ HOU | 10 | 58 | W | 7.0 | 4 | 1 | 1 | 0 | 3 | 7 | 108 | 47 | 61 | 56% | 2-5 | 4.98 | 1.45 |
| 2012-06-02 | Mat Latos | R | 24 | W 12-9 | @ HOU | 11 | 83 | - | 3.1 | 7 | 7 | 4 | 1 | 1 | 5 | 72 | 23 | 49 | 68% | 4-2 | 4.94 | 1.40 |
| 2012-06-03 | Bronson Arroyo | R | 35 | L 3-5 | @ HOU | 11 | 302 | L | 6.1 | 8 | 5 | 5 | 1 | 1 | 4 | 106 | 39 | 67 | 63% | 2-4 | 3.91 | 1.33 |
| 2012-06-05 | Homer Bailey | R | 26 | W 4-8 | vs PIT | 11 | 89 | L | 3.0 | 8 | 6 | 6 | 1 | 2 | 2 | 73 | 25 | 48 | 66% | 4-4 | 4.36 | 1.35 |
| 2012-06-06 | Johnny Cueto | R | 26 | L 5-4 | vs PIT | 12 | 128 | W | 7.2 | 6 | 3 | 3 | 0 | 1 | 6 | 116 | 44 | 72 | 62% | 6-3 | 2.62 | 1.22 |
| 2012-06-07 | Mike Leake | R | 25 | W 4-5 | vs PIT | 11 | 59 | - | 7.0 | 7 | 4 | 4 | 0 | 0 | 5 | 80 | 26 | 54 | 68% | 2-5 | 5.00 | 1.40 |
| 2012-06-08 | Mat Latos | R | 24 | L 6-5 | vs DET | 12 | 84 | - | 6.1 | 7 | 4 | 3 | 1 | 2 | 3 | 86 | 26 | 60 | 70% | 4-2 | 4.83 | 1.39 |
| 2012-06-09 | Bronson Arroyo | R | 35 | W 2-3 | vs DET | 12 | 303 | - | 7.0 | 5 | 2 | 2 | 2 | 0 | 4 | 87 | 22 | 65 | 75% | 2-4 | 3.79 | 1.28 |
| 2012-06-10 | Homer Bailey | R | 26 | W 6-7 | vs DET | 12 | 90 | - | 6.2 | 6 | 3 | 3 | 1 | 2 | 7 | 111 | 42 | 69 | 62% | 4-4 | 4.38 | 1.35 |
| 2012-06-12 | Johnny Cueto | R | 26 | L 7-1 | vs CLE | 13 | 129 | W | 9.0 | 6 | 1 | 1 | 0 | 0 | 7 | 120 | 41 | 79 | 66% | 7-3 | 2.45 | 1.16 |
| 2012-06-13 | Mat Latos | R | 25 | L 5-3 | vs CLE | 13 | 85 | W | 7.0 | 7 | 2 | 2 | 0 | 1 | 7 | 98 | 30 | 68 | 69% | 5-2 | 4.62 | 1.37 |
| 2012-06-14 | Mike Leake | R | 25 | L 12-5 | vs CLE | 12 | 60 | - | 4.1 | 7 | 3 | 3 | 2 | 2 | 6 | 84 | 31 | 53 | 63% | 2-5 | 5.03 | 1.43 |
| 2012-06-15 | Bronson Arroyo | R | 35 | W 7-3 | @ NYN | 13 | 304 | W | 6.0 | 4 | 3 | 3 | 2 | 2 | 5 | 97 | 36 | 61 | 63% | 3-4 | 3.84 | 1.26 |
| 2012-06-16 | Homer Bailey | R | 26 | W 4-1 | @ NYN | 13 | 91 | W | 8.0 | 6 | 1 | 1 | 0 | 1 | 3 | 104 | 37 | 67 | 64% | 5-4 | 4.05 | 1.30 |
| 2012-06-17 | Johnny Cueto | R | 26 | W 3-1 | @ NYN | 14 | 130 | W | 7.0 | 6 | 1 | 1 | 0 | 1 | 8 | 110 | 38 | 72 | 65% | 8-3 | 2.37 | 1.15 |
| 2012-06-18 | Mat Latos | R | 25 | L 9-10 | @ CLE | 14 | 86 | - | 4.0 | 8 | 7 | 7 | 3 | 0 | 4 | 62 | 21 | 41 | 66% | 5-2 | 5.18 | 1.40 |
| 2012-06-19 | Mike Leake | R | 25 | L 2-3 | @ CLE | 13 | 61 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 4 | 114 | 46 | 68 | 60% | 2-5 | 4.68 | 1.39 |
| 2012-06-20 | Bronson Arroyo | R | 35 | L 1-8 | @ CLE | 14 | 305 | L | 4.0 | 8 | 5 | 5 | 2 | 2 | 2 | 90 | 33 | 57 | 63% | 3-5 | 4.19 | 1.31 |
| 2012-06-22 | Homer Bailey | R | 26 | W 4-5 | vs MIN | 14 | 92 | L | 5.1 | 8 | 5 | 4 | 1 | 3 | 3 | 106 | 37 | 69 | 65% | 5-5 | 4.19 | 1.34 |
| 2012-06-23 | Johnny Cueto | R | 26 | L 6-0 | vs MIN | 15 | 131 | W | 7.0 | 3 | 0 | 0 | 0 | 1 | 9 | 115 | 43 | 72 | 63% | 9-3 | 2.21 | 1.11 |
| 2012-06-24 | Mike Leake | R | 25 | W 3-4 | vs MIN | 14 | 62 | - | 8.0 | 5 | 2 | 2 | 1 | 0 | 5 | 83 | 28 | 55 | 66% | 2-5 | 4.45 | 1.31 |
| 2012-06-25 | Mat Latos | R | 25 | L 3-1 | vs MIL | 15 | 87 | W | 9.0 | 4 | 1 | 1 | 1 | 2 | 13 | 108 | 29 | 79 | 73% | 6-2 | 4.75 | 1.33 |
| 2012-06-26 | Bronson Arroyo | R | 35 | L 4-3 | vs MIL | 15 | 306 | - | 7.2 | 3 | 3 | 3 | 0 | 1 | 4 | 104 | 36 | 68 | 65% | 3-5 | 4.12 | 1.24 |
| 2012-06-27 | Homer Bailey | R | 26 | W 4-8 | vs MIL | 15 | 93 | L | 4.0 | 7 | 5 | 4 | 2 | 1 | 1 | 71 | 24 | 47 | 66% | 5-6 | 4.40 | 1.37 |
| 2012-06-28 | Johnny Cueto | R | 26 | L 0-5 | @ SFN | 16 | 132 | L | 6.0 | 6 | 3 | 2 | 0 | 4 | 3 | 114 | 43 | 71 | 62% | 9-4 | 2.25 | 1.14 |
| 2012-06-29 | Mike Leake | R | 25 | W 5-1 | @ SFN | 15 | 63 | W | 9.0 | 9 | 1 | 1 | 1 | 1 | 4 | 115 | 38 | 77 | 67% | 3-5 | 4.11 | 1.29 |
| 2012-06-30 | Mat Latos | R | 25 | W 2-1 | @ SFN | 16 | 88 | W | 9.0 | 2 | 1 | 1 | 0 | 0 | 7 | 115 | 33 | 82 | 71% | 7-2 | 4.41 | 1.22 |
| 2012-07-01 | Bronson Arroyo | R | 35 | L 3-4 | @ SFN | 16 | 307 | - | 6.0 | 7 | 2 | 2 | 0 | 2 | 2 | 119 | 39 | 80 | 67% | 3-5 | 4.05 | 1.26 |
| 2012-07-02 | Homer Bailey | R | 26 | W 8-2 | @ LAN | 16 | 94 | W | 8.0 | 5 | 2 | 2 | 1 | 1 | 7 | 114 | 37 | 77 | 68% | 6-6 | 4.22 | 1.32 |
| 2012-07-03 | Johnny Cueto | R | 26 | L 1-3 | @ LAN | 17 | 133 | L | 7.0 | 7 | 3 | 3 | 0 | 0 | 7 | 111 | 38 | 73 | 66% | 9-5 | 2.35 | 1.13 |
| 2012-07-04 | Mike Leake | R | 25 | L 1-4 | @ LAN | 16 | 64 | L | 7.0 | 6 | 3 | 2 | 0 | 0 | 5 | 87 | 28 | 59 | 68% | 3-6 | 4.00 | 1.26 |
| 2012-07-05 | Mat Latos | R | 25 | L 1-2 | @ SDN | 17 | 89 | - | 7.0 | 4 | 0 | 0 | 0 | 2 | 8 | 109 | 38 | 71 | 65% | 7-2 | 4.11 | 1.20 |
| 2012-07-06 | Bronson Arroyo | R | 35 | W 6-0 | @ SDN | 17 | 308 | W | 9.0 | 3 | 0 | 0 | 0 | 1 | 8 | 110 | 38 | 72 | 65% | 4-5 | 3.72 | 1.19 |
| 2012-07-07 | Homer Bailey | R | 26 | W 6-5 | @ SDN | 17 | 95 | W | 6.2 | 7 | 4 | 2 | 1 | 0 | 8 | 116 | 40 | 76 | 66% | 7-6 | 4.15 | 1.31 |
| 2012-07-08 | Johnny Cueto | R | 26 | W 4-2 | @ SDN | 18 | 134 | W | 5.2 | 7 | 2 | 2 | 0 | 2 | 5 | 107 | 43 | 64 | 60% | 10-5 | 2.40 | 1.16 |
| 2012-07-13 | Mat Latos | R | 25 | L 5-3 | vs SLN | 18 | 90 | - | 5.0 | 4 | 2 | 2 | 0 | 3 | 5 | 95 | 36 | 59 | 62% | 7-2 | 4.09 | 1.21 |
| 2012-07-14 | Mike Leake | R | 25 | L 3-2 | vs SLN | 17 | 65 | - | 6.0 | 7 | 2 | 2 | 1 | 1 | 3 | 85 | 28 | 57 | 67% | 3-6 | 3.94 | 1.27 |
| 2012-07-15 | Homer Bailey | R | 26 | L 4-2 | vs SLN | 18 | 96 | W | 8.0 | 9 | 2 | 1 | 1 | 2 | 2 | 104 | 33 | 71 | 68% | 8-6 | 3.94 | 1.31 |
| 2012-07-16 | Bronson Arroyo | R | 35 | W 3-5 | vs ARI | 18 | 309 | L | 3.0 | 8 | 5 | 5 | 1 | 1 | 2 | 48 | 15 | 33 | 69% | 4-6 | 4.02 | 1.24 |
| 2012-07-17 | Johnny Cueto | R | 26 | L 4-0 | vs ARI | 19 | 135 | W | 6.0 | 4 | 0 | 0 | 0 | 4 | 3 | 104 | 46 | 58 | 56% | 11-5 | 2.29 | 1.17 |
| 2012-07-18 | Mat Latos | R | 25 | W 1-7 | vs ARI | 19 | 91 | L | 4.2 | 6 | 5 | 5 | 2 | 2 | 3 | 74 | 25 | 49 | 66% | 7-3 | 4.34 | 1.24 |
| 2012-07-19 | Mike Leake | R | 25 | L 7-6 | vs ARI | 18 | 66 | - | 5.1 | 11 | 6 | 6 | 2 | 1 | 2 | 93 | 37 | 56 | 60% | 3-6 | 4.25 | 1.32 |
| 2012-07-20 | Homer Bailey | R | 26 | L 3-1 | vs MIL | 19 | 97 | W | 8.0 | 6 | 1 | 1 | 0 | 0 | 10 | 112 | 34 | 78 | 70% | 9-6 | 3.75 | 1.28 |
| 2012-07-21 | Bronson Arroyo | R | 35 | L 6-2 | vs MIL | 19 | 310 | W | 6.0 | 5 | 2 | 2 | 0 | 2 | 6 | 85 | 29 | 56 | 66% | 5-6 | 3.97 | 1.24 |
| 2012-07-22 | Johnny Cueto | R | 26 | L 2-1 | vs MIL | 20 | 136 | W | 7.0 | 8 | 1 | 1 | 0 | 1 | 9 | 116 | 39 | 77 | 66% | 12-5 | 2.23 | 1.17 |
| 2012-07-23 | Mat Latos | R | 25 | W 8-3 | @ HOU | 20 | 92 | W | 5.0 | 8 | 2 | 2 | 0 | 2 | 3 | 95 | 37 | 58 | 61% | 8-3 | 4.31 | 1.27 |
| 2012-07-24 | Mike Leake | R | 25 | W 4-2 | @ HOU | 19 | 67 | W | 8.0 | 7 | 2 | 2 | 1 | 1 | 6 | 116 | 40 | 76 | 66% | 4-6 | 4.12 | 1.30 |
| 2012-07-25 | Homer Bailey | R | 26 | W 5-3 | @ HOU | 20 | 98 | - | 7.0 | 5 | 0 | 0 | 0 | 5 | 7 | 121 | 51 | 70 | 58% | 9-6 | 3.54 | 1.28 |
| 2012-07-27 | Bronson Arroyo | R | 35 | W 3-0 | @ COL | 20 | 311 | W | 6.2 | 6 | 0 | 0 | 0 | 0 | 3 | 85 | 24 | 61 | 72% | 6-6 | 3.77 | 1.23 |
| 2012-07-28 | Johnny Cueto | R | 26 | W 9-7 | @ COL | 21 | 137 | W | 6.0 | 10 | 5 | 4 | 0 | 2 | 3 | 102 | 38 | 64 | 63% | 13-5 | 2.40 | 1.21 |
| 2012-07-29 | Mat Latos | R | 25 | W 7-2 | @ COL | 21 | 93 | W | 8.0 | 4 | 2 | 2 | 1 | 3 | 8 | 116 | 38 | 78 | 67% | 9-3 | 4.18 | 1.24 |
| 2012-07-30 | Mike Leake | R | 25 | W 5-11 | vs SDN | 20 | 68 | L | 1.2 | 5 | 5 | 5 | 0 | 3 | 1 | 49 | 24 | 25 | 51% | 4-7 | 4.43 | 1.34 |
| 2012-07-31 | Homer Bailey | R | 26 | L 7-6 | vs SDN | 21 | 99 | - | 3.2 | 9 | 6 | 6 | 1 | 2 | 2 | 83 | 28 | 55 | 66% | 9-6 | 3.85 | 1.33 |
| 2012-08-01 | Bronson Arroyo | R | 35 | L 6-4 | vs SDN | 21 | 312 | W | 6.0 | 7 | 4 | 4 | 1 | 2 | 1 | 86 | 34 | 52 | 60% | 7-6 | 3.88 | 1.24 |
| 2012-08-02 | Johnny Cueto | R | 26 | L 9-4 | vs SDN | 22 | 138 | W | 7.1 | 8 | 4 | 4 | 2 | 1 | 9 | 100 | 29 | 71 | 71% | 14-5 | 2.51 | 1.20 |
| 2012-08-03 | Mat Latos | R | 25 | L 3-0 | vs PIT | 22 | 94 | W | 7.1 | 4 | 0 | 0 | 0 | 3 | 5 | 94 | 34 | 60 | 64% | 10-3 | 3.93 | 1.22 |
| 2012-08-04 | Mike Leake | R | 25 | L 5-4 | vs PIT | 21 | 69 | - | 6.0 | 6 | 4 | 4 | 2 | 1 | 7 | 102 | 34 | 68 | 67% | 4-7 | 4.50 | 1.33 |
| 2012-08-05 | Homer Bailey | R | 26 | W 2-6 | vs PIT | 22 | 100 | L | 4.2 | 9 | 4 | 4 | 1 | 1 | 3 | 90 | 27 | 63 | 70% | 9-7 | 3.97 | 1.35 |
| 2012-08-06 | Bronson Arroyo | R | 35 | L 3-6 | @ MIL | 22 | 313 | L | 5.1 | 10 | 5 | 5 | 3 | 0 | 5 | 76 | 20 | 56 | 74% | 7-7 | 4.04 | 1.26 |
| 2012-08-07 | Johnny Cueto | R | 26 | L 1-3 | @ MIL | 23 | 139 | L | 7.0 | 6 | 3 | 3 | 1 | 0 | 9 | 97 | 27 | 70 | 72% | 14-6 | 2.57 | 1.19 |
| 2012-08-08 | Mat Latos | R | 25 | L 2-3 | @ MIL | 23 | 95 | - | 7.0 | 3 | 1 | 1 | 1 | 1 | 8 | 94 | 30 | 64 | 68% | 10-3 | 3.80 | 1.19 |
| 2012-08-09 | Mike Leake | R | 25 | L 3-5 | @ CHN | 22 | 70 | - | 6.0 | 6 | 3 | 3 | 0 | 2 | 5 | 97 | 34 | 63 | 65% | 4-7 | 4.50 | 1.33 |
| 2012-08-10 | Homer Bailey | R | 26 | W 10-8 | @ CHN | 23 | 101 | W | 5.2 | 9 | 4 | 4 | 0 | 2 | 5 | 111 | 43 | 68 | 61% | 10-7 | 4.09 | 1.38 |
| 2012-08-11 | Bronson Arroyo | R | 35 | W 4-2 | @ CHN | 23 | 314 | W | 8.0 | 5 | 2 | 2 | 0 | 1 | 4 | 104 | 29 | 75 | 72% | 8-7 | 3.94 | 1.23 |
| 2012-08-12 | Johnny Cueto | R | 26 | W 3-0 | @ CHN | 24 | 140 | W | 8.0 | 3 | 0 | 0 | 0 | 2 | 3 | 112 | 41 | 71 | 63% | 15-6 | 2.44 | 1.16 |
| 2012-08-14 | Mat Latos | R | 25 | L 3-0 | vs NYN | 24 | 96 | - | 7.0 | 5 | 0 | 0 | 0 | 2 | 4 | 104 | 33 | 71 | 68% | 10-3 | 3.62 | 1.18 |
| 2012-08-15 | Mike Leake | R | 25 | L 6-1 | vs NYN | 23 | 71 | W | 9.0 | 4 | 1 | 1 | 0 | 0 | 4 | 110 | 41 | 69 | 63% | 5-7 | 4.28 | 1.28 |
| 2012-08-16 | Homer Bailey | R | 26 | W 4-8 | vs NYN | 24 | 102 | L | 5.2 | 8 | 6 | 4 | 2 | 3 | 6 | 101 | 36 | 65 | 64% | 10-8 | 4.16 | 1.40 |
| 2012-08-17 | Bronson Arroyo | R | 35 | L 7-3 | vs CHN | 24 | 315 | W | 6.1 | 9 | 3 | 3 | 1 | 3 | 3 | 109 | 41 | 68 | 62% | 9-7 | 3.96 | 1.26 |
| 2012-08-18 | Johnny Cueto | R | 27 | L 5-3 | vs CHN | 25 | 141 | W | 8.0 | 3 | 2 | 2 | 1 | 0 | 8 | 105 | 33 | 72 | 69% | 16-6 | 2.44 | 1.12 |
| 2012-08-18 | Todd Redmond | R | 27 | W 7-9 | vs CHN | 1 | 1 | L | 3.1 | 7 | 4 | 4 | 1 | 5 | 2 | 91 | 39 | 52 | 57% | 0-1 | 12.00 | 4.00 |
| 2012-08-19 | Mat Latos | R | 25 | L 5-4 | vs CHN | 25 | 97 | - | 8.0 | 6 | 4 | 2 | 0 | 3 | 6 | 114 | 44 | 70 | 61% | 10-3 | 3.55 | 1.18 |
| 2012-08-20 | Mike Leake | R | 25 | L 5-12 | @ PHI | 24 | 72 | L | 4.1 | 10 | 7 | 7 | 2 | 1 | 4 | 96 | 37 | 59 | 61% | 5-8 | 4.59 | 1.32 |
| 2012-08-21 | Homer Bailey | R | 26 | W 5-4 | @ PHI | 25 | 103 | - | 6.1 | 7 | 3 | 2 | 0 | 0 | 6 | 98 | 39 | 59 | 60% | 10-8 | 4.12 | 1.39 |
| 2012-08-22 | Bronson Arroyo | R | 35 | W 3-2 | @ PHI | 25 | 316 | W | 8.0 | 3 | 2 | 2 | 1 | 0 | 4 | 85 | 25 | 60 | 71% | 10-7 | 3.87 | 1.22 |
| 2012-08-23 | Johnny Cueto | R | 27 | L 3-4 | @ PHI | 26 | 142 | - | 5.0 | 5 | 2 | 2 | 0 | 3 | 4 | 112 | 42 | 70 | 63% | 16-6 | 2.47 | 1.14 |
| 2012-08-24 | Mat Latos | R | 25 | W 5-8 | vs SLN | 26 | 98 | L | 5.0 | 9 | 7 | 7 | 2 | 1 | 5 | 93 | 32 | 61 | 66% | 10-4 | 3.83 | 1.20 |
| 2012-08-25 | Mike Leake | R | 25 | L 8-2 | vs SLN | 25 | 73 | W | 6.2 | 10 | 2 | 2 | 0 | 0 | 3 | 82 | 24 | 58 | 71% | 6-8 | 4.50 | 1.32 |
| 2012-08-26 | Homer Bailey | R | 26 | W 2-8 | vs SLN | 26 | 104 | L | 6.0 | 9 | 5 | 5 | 1 | 0 | 3 | 89 | 31 | 58 | 65% | 10-9 | 4.25 | 1.40 |
| 2012-08-27 | Bronson Arroyo | R | 36 | W 3-2 | @ ARI | 26 | 317 | W | 6.0 | 5 | 2 | 2 | 1 | 1 | 3 | 98 | 34 | 64 | 65% | 11-7 | 3.84 | 1.21 |
| 2012-08-28 | Johnny Cueto | R | 27 | W 5-2 | @ ARI | 27 | 143 | W | 7.0 | 4 | 2 | 2 | 0 | 1 | 5 | 107 | 31 | 76 | 71% | 17-6 | 2.47 | 1.12 |
| 2012-08-29 | Mat Latos | R | 25 | W 6-2 | @ ARI | 27 | 99 | W | 7.0 | 5 | 2 | 2 | 0 | 3 | 7 | 118 | 43 | 75 | 64% | 11-4 | 3.78 | 1.20 |
| 2012-08-31 | Mike Leake | R | 25 | W 9-3 | @ HOU | 26 | 74 | W | 6.0 | 7 | 2 | 2 | 2 | 2 | 6 | 105 | 38 | 67 | 64% | 7-8 | 4.44 | 1.33 |
| 2012-09-01 | Homer Bailey | R | 26 | L 1-2 | @ HOU | 27 | 105 | - | 8.0 | 3 | 1 | 1 | 1 | 1 | 9 | 107 | 41 | 66 | 62% | 10-9 | 4.10 | 1.35 |
| 2012-09-02 | Bronson Arroyo | R | 36 | W 5-3 | @ HOU | 27 | 318 | - | 6.0 | 3 | 1 | 1 | 0 | 1 | 2 | 76 | 26 | 50 | 66% | 11-7 | 3.76 | 1.19 |
| 2012-09-03 | Johnny Cueto | R | 27 | W 2-4 | vs PHI | 28 | 144 | L | 7.0 | 8 | 4 | 4 | 2 | 0 | 5 | 97 | 27 | 70 | 72% | 17-7 | 2.57 | 1.12 |
| 2012-09-04 | Mat Latos | R | 25 | L 2-1 | vs PHI | 28 | 100 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 6 | 100 | 37 | 63 | 63% | 12-4 | 3.68 | 1.19 |
| 2012-09-05 | Mike Leake | R | 25 | W 2-6 | vs PHI | 27 | 75 | L | 2.1 | 6 | 6 | 6 | 2 | 1 | 1 | 56 | 22 | 34 | 61% | 7-9 | 4.73 | 1.36 |
| 2012-09-07 | Homer Bailey | R | 26 | W 3-5 | vs HOU | 28 | 106 | - | 6.2 | 5 | 2 | 2 | 1 | 1 | 9 | 117 | 36 | 81 | 69% | 10-9 | 4.03 | 1.33 |
| 2012-09-08 | Bronson Arroyo | R | 36 | L 5-1 | vs HOU | 28 | 319 | W | 7.0 | 7 | 1 | 1 | 0 | 2 | 5 | 98 | 31 | 67 | 68% | 12-7 | 3.66 | 1.19 |
| 2012-09-09 | Johnny Cueto | R | 27 | W 1-5 | vs HOU | 29 | 145 | L | 4.0 | 9 | 4 | 4 | 1 | 1 | 6 | 82 | 30 | 52 | 63% | 17-8 | 2.70 | 1.15 |
| 2012-09-10 | Mat Latos | R | 25 | L 4-3 | vs PIT | 29 | 101 | - | 6.0 | 5 | 3 | 3 | 1 | 4 | 5 | 105 | 45 | 60 | 57% | 12-4 | 3.71 | 1.20 |
| 2012-09-11 | Mike Leake | R | 25 | L 5-3 | vs PIT | 28 | 76 | W | 7.0 | 9 | 3 | 3 | 2 | 1 | 3 | 91 | 26 | 65 | 71% | 8-9 | 4.69 | 1.36 |
| 2012-09-12 | Homer Bailey | R | 26 | L 2-1 | vs PIT | 29 | 107 | W | 7.0 | 6 | 1 | 1 | 0 | 2 | 4 | 114 | 38 | 76 | 67% | 11-9 | 3.93 | 1.33 |
| 2012-09-14 | Bronson Arroyo | R | 36 | L 0-4 | @ MIA | 29 | 320 | L | 6.0 | 9 | 4 | 4 | 1 | 2 | 6 | 105 | 37 | 68 | 65% | 12-8 | 3.74 | 1.21 |
| 2012-09-15 | Johnny Cueto | R | 27 | L 4-6 | @ MIA | 30 | 146 | L | 4.1 | 9 | 6 | 6 | 1 | 2 | 2 | 97 | 38 | 59 | 61% | 17-9 | 2.92 | 1.18 |
| 2012-09-16 | Mat Latos | R | 25 | W 5-4 | @ MIA | 30 | 102 | - | 7.2 | 7 | 4 | 4 | 0 | 3 | 8 | 109 | 43 | 66 | 61% | 12-4 | 3.76 | 1.21 |
| 2012-09-18 | Homer Bailey | R | 26 | W 3-1 | @ CHN | 30 | 108 | W | 7.1 | 4 | 1 | 1 | 0 | 2 | 4 | 106 | 40 | 66 | 62% | 12-9 | 3.83 | 1.31 |
| 2012-09-19 | Mike Leake | R | 25 | W 6-5 | @ CHN | 29 | 77 | - | 6.0 | 6 | 4 | 4 | 1 | 2 | 1 | 86 | 34 | 52 | 60% | 8-9 | 4.73 | 1.36 |
| 2012-09-20 | Johnny Cueto | R | 27 | W 5-3 | @ CHN | 31 | 147 | W | 6.0 | 5 | 0 | 0 | 0 | 4 | 2 | 97 | 43 | 54 | 56% | 18-9 | 2.84 | 1.19 |
| 2012-09-21 | Bronson Arroyo | R | 36 | W 1-3 | vs LAN | 30 | 321 | - | 8.0 | 6 | 1 | 1 | 0 | 0 | 4 | 87 | 23 | 64 | 74% | 12-8 | 3.63 | 1.19 |
| 2012-09-22 | Mat Latos | R | 25 | L 6-0 | vs LAN | 31 | 103 | W | 8.0 | 6 | 0 | 0 | 0 | 0 | 7 | 105 | 27 | 78 | 74% | 13-4 | 3.61 | 1.19 |
| 2012-09-23 | Homer Bailey | R | 26 | W 3-5 | vs LAN | 31 | 109 | L | 6.2 | 5 | 5 | 5 | 2 | 2 | 6 | 104 | 41 | 63 | 61% | 12-10 | 3.92 | 1.30 |
| 2012-09-25 | Johnny Cueto | R | 27 | L 4-2 | vs MIL | 32 | 148 | W | 7.0 | 5 | 2 | 2 | 1 | 0 | 5 | 93 | 31 | 62 | 67% | 19-9 | 2.83 | 1.18 |
| 2012-09-26 | Bronson Arroyo | R | 36 | W 1-8 | vs MIL | 31 | 322 | L | 6.0 | 8 | 4 | 4 | 1 | 1 | 1 | 89 | 27 | 62 | 70% | 12-9 | 3.70 | 1.20 |
| 2012-09-27 | Mat Latos | R | 25 | L 2-1 | vs MIL | 32 | 104 | - | 7.0 | 3 | 1 | 1 | 1 | 1 | 3 | 89 | 30 | 59 | 66% | 13-4 | 3.53 | 1.17 |
| 2012-09-28 | Homer Bailey | R | 26 | W 1-0 | @ PIT | 32 | 110 | W | 9.0 | 0 | 0 | 0 | 0 | 1 | 10 | 116 | 44 | 72 | 62% | 13-10 | 3.75 | 1.25 |
| 2012-09-29 | Mike Leake | R | 25 | L 1-2 | @ PIT | 30 | 78 | - | 6.0 | 4 | 0 | 0 | 0 | 3 | 3 | 86 | 37 | 49 | 57% | 8-9 | 4.58 | 1.35 |
| 2012-09-30 | Johnny Cueto | R | 27 | W 4-3 | @ PIT | 33 | 149 | - | 7.0 | 6 | 3 | 1 | 1 | 1 | 6 | 98 | 30 | 68 | 69% | 19-9 | 2.78 | 1.17 |
| 2012-10-01 | Bronson Arroyo | R | 36 | L 2-4 | @ SLN | 32 | 323 | L | 5.0 | 6 | 3 | 3 | 1 | 1 | 6 | 72 | 28 | 44 | 61% | 12-10 | 3.74 | 1.21 |
| 2012-10-02 | Mat Latos | R | 25 | W 3-1 | @ SLN | 33 | 105 | W | 5.0 | 4 | 1 | 1 | 0 | 1 | 4 | 78 | 24 | 54 | 69% | 14-4 | 3.49 | 1.16 |
| 2012-10-03 | Homer Bailey | R | 26 | L 0-1 | @ SLN | 33 | 111 | - | 4.0 | 4 | 0 | 0 | 0 | 0 | 6 | 72 | 24 | 48 | 67% | 13-10 | 3.68 | 1.24 |