| East | W | L | Pct | GB |
| NY Yankees | 95 | 67 | .586 | -- |
| Baltimore | 93 | 69 | .574 | 2.0 |
| Tampa Bay | 90 | 72 | .556 | 5.0 |
| Toronto | 73 | 89 | .451 | 22.0 |
| Boston | 69 | 93 | .426 | 26.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-04-06 | Jake Arrieta | R | 26 | L 4-2 | vs MIN | 1 | 41 | W | 7.0 | 2 | 0 | 0 | 0 | 2 | 4 | 97 | 37 | 60 | 62% | 1-0 | 0.00 | 0.57 |
| 2012-04-07 | Tommy Hunter | R | 26 | L 8-2 | vs MIN | 1 | 56 | W | 7.0 | 6 | 2 | 0 | 0 | 1 | 3 | 98 | 34 | 64 | 65% | 1-0 | 0.00 | 1.00 |
| 2012-04-08 | Jason Hammel | R | 30 | L 3-1 | vs MIN | 1 | 116 | W | 8.0 | 2 | 1 | 1 | 0 | 3 | 5 | 96 | 37 | 59 | 61% | 1-0 | 1.13 | 0.63 |
| 2012-04-09 | Brian Matusz | L | 25 | W 2-6 | vs NYA | 1 | 53 | L | 4.0 | 6 | 4 | 4 | 0 | 4 | 1 | 95 | 44 | 51 | 54% | 0-1 | 9.00 | 2.50 |
| 2012-04-10 | Wei-Yin Chen | L | 27 | W 4-5 | vs NYA | 1 | 1 | - | 5.2 | 7 | 4 | 2 | 1 | 1 | 6 | 100 | 42 | 58 | 58% | 0-0 | 3.00 | 1.33 |
| 2012-04-11 | Jake Arrieta | R | 26 | W 4-6 | vs NYA | 2 | 42 | - | 6.2 | 5 | 4 | 4 | 1 | 1 | 5 | 109 | 39 | 70 | 64% | 1-0 | 2.57 | 0.71 |
| 2012-04-13 | Tommy Hunter | R | 26 | W 7-5 | @ TOR | 2 | 57 | - | 6.0 | 6 | 5 | 4 | 4 | 2 | 2 | 83 | 28 | 55 | 66% | 1-0 | 2.77 | 1.15 |
| 2012-04-14 | Jason Hammel | R | 30 | W 6-4 | @ TOR | 2 | 117 | - | 5.0 | 6 | 2 | 2 | 1 | 1 | 3 | 96 | 37 | 59 | 61% | 1-0 | 2.08 | 0.92 |
| 2012-04-15 | Brian Matusz | L | 25 | L 2-9 | @ TOR | 2 | 54 | L | 5.2 | 7 | 5 | 5 | 2 | 4 | 4 | 105 | 39 | 66 | 63% | 0-2 | 8.10 | 2.10 |
| 2012-04-16 | Jake Arrieta | R | 26 | W 10-4 | @ CHA | 3 | 43 | - | 6.2 | 7 | 4 | 2 | 1 | 1 | 7 | 117 | 45 | 72 | 62% | 1-0 | 2.70 | 0.90 |
| 2012-04-17 | Wei-Yin Chen | L | 27 | W 3-2 | @ CHA | 2 | 2 | W | 5.1 | 6 | 2 | 2 | 0 | 2 | 4 | 105 | 39 | 66 | 63% | 1-0 | 3.27 | 1.45 |
| 2012-04-18 | Tommy Hunter | R | 26 | L 1-8 | @ CHA | 3 | 58 | L | 5.2 | 9 | 8 | 8 | 2 | 4 | 8 | 99 | 40 | 59 | 60% | 1-1 | 5.68 | 1.47 |
| 2012-04-19 | Jason Hammel | R | 30 | W 5-3 | @ CHA | 3 | 118 | W | 6.0 | 6 | 2 | 2 | 0 | 3 | 10 | 108 | 37 | 71 | 66% | 2-0 | 2.37 | 1.11 |
| 2012-04-20 | Brian Matusz | L | 25 | L 3-6 | @ ANA | 3 | 55 | L | 5.0 | 9 | 6 | 4 | 0 | 3 | 6 | 99 | 32 | 67 | 68% | 0-3 | 7.80 | 2.20 |
| 2012-04-21 | Jake Arrieta | R | 26 | L 3-6 | @ ANA | 4 | 44 | L | 4.1 | 6 | 5 | 5 | 0 | 3 | 5 | 87 | 40 | 47 | 54% | 1-1 | 3.96 | 1.08 |
| 2012-04-22 | Wei-Yin Chen | L | 27 | W 3-2 | @ ANA | 3 | 3 | - | 6.1 | 5 | 1 | 1 | 0 | 3 | 5 | 94 | 38 | 56 | 60% | 1-0 | 2.65 | 1.41 |
| 2012-04-24 | Tommy Hunter | R | 26 | L 2-1 | vs TOR | 4 | 59 | W | 6.0 | 3 | 1 | 1 | 1 | 3 | 3 | 103 | 37 | 66 | 64% | 2-1 | 4.68 | 1.36 |
| 2012-04-25 | Jason Hammel | R | 30 | L 3-0 | vs TOR | 4 | 119 | W | 7.0 | 4 | 0 | 0 | 0 | 1 | 7 | 105 | 40 | 65 | 62% | 3-0 | 1.73 | 1.00 |
| 2012-04-26 | Brian Matusz | L | 25 | L 5-2 | vs TOR | 4 | 56 | - | 6.0 | 4 | 2 | 0 | 0 | 2 | 3 | 91 | 29 | 62 | 68% | 0-3 | 5.57 | 1.86 |
| 2012-04-27 | Jake Arrieta | R | 26 | W 2-5 | vs OAK | 5 | 45 | L | 5.2 | 4 | 4 | 4 | 2 | 2 | 3 | 105 | 43 | 62 | 59% | 1-2 | 4.50 | 1.10 |
| 2012-04-28 | Wei-Yin Chen | L | 27 | L 10-1 | vs OAK | 4 | 4 | W | 7.0 | 6 | 1 | 1 | 1 | 2 | 4 | 105 | 41 | 64 | 61% | 2-0 | 2.25 | 1.33 |
| 2012-04-29 | Tommy Hunter | R | 26 | L 5-2 | vs OAK | 5 | 60 | - | 7.0 | 7 | 2 | 2 | 1 | 1 | 2 | 102 | 38 | 64 | 63% | 2-1 | 4.22 | 1.31 |
| 2012-04-30 | Jason Hammel | R | 30 | L 1-2 | @ NYA | 5 | 120 | L | 6.0 | 5 | 2 | 2 | 1 | 2 | 5 | 100 | 41 | 59 | 59% | 3-1 | 1.97 | 1.03 |
| 2012-05-01 | Brian Matusz | L | 25 | W 7-1 | @ NYA | 5 | 57 | W | 6.1 | 6 | 1 | 1 | 1 | 1 | 4 | 96 | 34 | 62 | 65% | 1-3 | 4.67 | 1.70 |
| 2012-05-02 | Jake Arrieta | R | 26 | W 5-0 | @ NYA | 6 | 46 | W | 8.0 | 5 | 0 | 0 | 0 | 0 | 9 | 109 | 35 | 74 | 68% | 2-2 | 3.55 | 1.00 |
| 2012-05-04 | Wei-Yin Chen | L | 27 | W 6-4 | @ BOS | 5 | 5 | - | 5.0 | 5 | 4 | 3 | 0 | 3 | 4 | 101 | 42 | 59 | 58% | 2-0 | 2.79 | 1.38 |
| 2012-05-05 | Jason Hammel | R | 30 | W 8-2 | @ BOS | 6 | 121 | W | 6.2 | 4 | 2 | 2 | 0 | 1 | 8 | 114 | 43 | 71 | 62% | 4-1 | 2.08 | 0.97 |
| 2012-05-06 | Tommy Hunter | R | 26 | W 9-6 | @ BOS | 6 | 61 | - | 4.1 | 8 | 5 | 5 | 1 | 1 | 2 | 81 | 28 | 53 | 65% | 2-1 | 5.00 | 1.42 |
| 2012-05-07 | Brian Matusz | L | 25 | W 3-14 | vs TEX | 6 | 58 | L | 5.0 | 10 | 7 | 7 | 1 | 2 | 4 | 103 | 39 | 64 | 62% | 1-4 | 5.91 | 1.81 |
| 2012-05-08 | Jake Arrieta | R | 26 | W 3-10 | vs TEX | 7 | 47 | L | 6.1 | 9 | 6 | 6 | 3 | 1 | 3 | 97 | 35 | 62 | 64% | 2-3 | 4.20 | 1.07 |
| 2012-05-10 | Wei-Yin Chen | L | 27 | L 6-5 | vs TEX | 6 | 6 | W | 7.2 | 6 | 2 | 1 | 0 | 1 | 5 | 103 | 33 | 70 | 68% | 3-0 | 2.43 | 1.27 |
| 2012-05-10 | Tommy Hunter | R | 26 | W 3-7 | vs TEX | 7 | 62 | L | 6.0 | 5 | 4 | 4 | 1 | 1 | 7 | 88 | 28 | 60 | 68% | 2-2 | 5.14 | 1.36 |
| 2012-05-11 | Dana Eveland | L | 29 | L 4-3 | vs TBA | 1 | 60 | - | 6.0 | 5 | 3 | 3 | 0 | 6 | 2 | 94 | 44 | 50 | 53% | 0-0 | 4.50 | 1.83 |
| 2012-05-12 | Brian Matusz | L | 25 | L 5-3 | vs TBA | 7 | 59 | W | 5.2 | 7 | 3 | 2 | 1 | 1 | 5 | 95 | 31 | 64 | 67% | 2-4 | 5.45 | 1.74 |
| 2012-05-13 | Jake Arrieta | R | 26 | W 8-9 | vs TBA | 8 | 48 | L | 3.2 | 10 | 7 | 7 | 0 | 2 | 6 | 78 | 29 | 49 | 63% | 2-4 | 5.25 | 1.25 |
| 2012-05-14 | Jason Hammel | R | 30 | W 5-8 | vs NYA | 7 | 122 | - | 5.0 | 7 | 5 | 4 | 1 | 3 | 3 | 95 | 35 | 60 | 63% | 4-1 | 2.66 | 1.09 |
| 2012-05-15 | Wei-Yin Chen | L | 27 | L 5-2 | vs NYA | 7 | 7 | W | 7.0 | 4 | 2 | 2 | 1 | 2 | 4 | 104 | 40 | 64 | 62% | 4-0 | 2.45 | 1.20 |
| 2012-05-16 | Tommy Hunter | R | 26 | W 4-3 | @ KCA | 8 | 63 | - | 7.0 | 7 | 2 | 2 | 0 | 1 | 1 | 82 | 27 | 55 | 67% | 2-2 | 4.78 | 1.33 |
| 2012-05-17 | Brian Matusz | L | 25 | W 5-3 | @ KCA | 8 | 60 | W | 6.0 | 7 | 3 | 3 | 0 | 1 | 2 | 98 | 30 | 68 | 69% | 3-4 | 5.32 | 1.68 |
| 2012-05-18 | Jake Arrieta | R | 26 | W 2-1 | @ WAS | 9 | 49 | - | 7.0 | 6 | 1 | 1 | 1 | 1 | 9 | 110 | 40 | 70 | 64% | 2-4 | 4.75 | 1.22 |
| 2012-05-19 | Jason Hammel | R | 30 | W 6-5 | @ WAS | 8 | 123 | W | 5.1 | 6 | 4 | 4 | 0 | 2 | 5 | 92 | 41 | 51 | 55% | 5-1 | 3.12 | 1.14 |
| 2012-05-20 | Wei-Yin Chen | L | 27 | L 3-9 | @ WAS | 8 | 8 | L | 4.1 | 8 | 6 | 6 | 2 | 3 | 5 | 91 | 34 | 57 | 63% | 4-1 | 3.38 | 1.33 |
| 2012-05-21 | Tommy Hunter | R | 26 | W 6-8 | vs BOS | 9 | 64 | - | 6.0 | 9 | 5 | 5 | 1 | 0 | 3 | 93 | 31 | 62 | 67% | 2-2 | 5.07 | 1.35 |
| 2012-05-22 | Brian Matusz | L | 25 | L 4-1 | vs BOS | 9 | 61 | W | 6.1 | 2 | 1 | 1 | 1 | 1 | 9 | 100 | 34 | 66 | 66% | 4-4 | 4.86 | 1.54 |
| 2012-05-23 | Jake Arrieta | R | 26 | W 5-6 | vs BOS | 10 | 50 | L | 5.2 | 8 | 4 | 4 | 1 | 3 | 2 | 98 | 40 | 58 | 59% | 2-5 | 4.87 | 1.28 |
| 2012-05-25 | Jason Hammel | R | 30 | L 8-2 | vs KCA | 9 | 124 | W | 6.0 | 5 | 0 | 0 | 0 | 1 | 7 | 100 | 36 | 64 | 64% | 6-1 | 2.78 | 1.13 |
| 2012-05-26 | Wei-Yin Chen | L | 27 | W 3-4 | vs KCA | 9 | 9 | - | 6.0 | 6 | 2 | 2 | 1 | 1 | 5 | 97 | 35 | 62 | 64% | 4-1 | 3.33 | 1.31 |
| 2012-05-27 | Brian Matusz | L | 25 | W 2-4 | vs KCA | 10 | 62 | L | 6.0 | 7 | 4 | 3 | 2 | 3 | 5 | 100 | 35 | 65 | 65% | 4-5 | 4.82 | 1.55 |
| 2012-05-28 | Tommy Hunter | R | 26 | L 2-6 | @ TOR | 10 | 65 | L | 3.0 | 9 | 6 | 5 | 2 | 0 | 0 | 69 | 24 | 45 | 65% | 2-3 | 5.59 | 1.43 |
| 2012-05-29 | Jake Arrieta | R | 26 | L 6-8 | @ TOR | 11 | 51 | L | 4.1 | 6 | 7 | 6 | 0 | 3 | 5 | 96 | 40 | 56 | 58% | 2-6 | 5.40 | 1.34 |
| 2012-05-30 | Jason Hammel | R | 30 | L 1-4 | @ TOR | 10 | 125 | L | 6.2 | 9 | 4 | 4 | 4 | 2 | 5 | 107 | 39 | 68 | 64% | 6-2 | 3.05 | 1.18 |
| 2012-06-01 | Wei-Yin Chen | L | 27 | L 0-5 | @ TBA | 10 | 10 | L | 5.2 | 5 | 5 | 5 | 1 | 4 | 5 | 96 | 36 | 60 | 63% | 4-2 | 3.75 | 1.33 |
| 2012-06-02 | Brian Matusz | L | 25 | W 2-1 | @ TBA | 11 | 63 | W | 7.1 | 2 | 1 | 1 | 0 | 3 | 7 | 96 | 34 | 62 | 65% | 5-5 | 4.43 | 1.46 |
| 2012-06-03 | Jake Arrieta | R | 26 | L 4-8 | @ TBA | 12 | 52 | L | 4.2 | 2 | 4 | 4 | 0 | 4 | 3 | 85 | 44 | 41 | 48% | 2-7 | 5.53 | 1.33 |
| 2012-06-05 | Jason Hammel | R | 30 | W 8-6 | @ BOS | 11 | 126 | - | 5.0 | 5 | 2 | 1 | 0 | 3 | 7 | 108 | 47 | 61 | 56% | 6-2 | 2.96 | 1.21 |
| 2012-06-06 | Wei-Yin Chen | L | 27 | W 2-1 | @ BOS | 11 | 11 | W | 7.0 | 7 | 1 | 1 | 0 | 0 | 4 | 100 | 31 | 69 | 69% | 5-2 | 3.49 | 1.30 |
| 2012-06-07 | Brian Matusz | L | 25 | L 0-7 | @ BOS | 12 | 64 | L | 2.0 | 4 | 5 | 4 | 0 | 5 | 0 | 67 | 34 | 33 | 49% | 5-6 | 4.85 | 1.55 |
| 2012-06-08 | Jake Arrieta | R | 26 | W 6-9 | vs PHI | 13 | 53 | L | 4.0 | 11 | 9 | 9 | 2 | 0 | 5 | 83 | 30 | 53 | 64% | 2-8 | 6.32 | 1.41 |
| 2012-06-09 | Tommy Hunter | R | 26 | L 6-4 | vs PHI | 11 | 66 | - | 7.0 | 8 | 3 | 3 | 3 | 0 | 2 | 85 | 27 | 58 | 68% | 2-3 | 5.40 | 1.40 |
| 2012-06-10 | Jason Hammel | R | 30 | L 5-4 | vs PHI | 12 | 127 | - | 6.0 | 6 | 4 | 4 | 0 | 5 | 4 | 114 | 47 | 67 | 59% | 6-2 | 3.21 | 1.26 |
| 2012-06-12 | Wei-Yin Chen | L | 27 | L 8-6 | vs PIT | 12 | 12 | W | 6.1 | 8 | 4 | 4 | 1 | 2 | 4 | 103 | 36 | 67 | 65% | 6-2 | 3.70 | 1.33 |
| 2012-06-13 | Jake Arrieta | R | 26 | L 7-1 | vs PIT | 14 | 54 | W | 7.0 | 7 | 1 | 1 | 0 | 1 | 9 | 107 | 39 | 68 | 64% | 3-8 | 5.89 | 1.38 |
| 2012-06-14 | Tommy Hunter | R | 26 | L 12-6 | vs PIT | 12 | 67 | W | 6.0 | 7 | 5 | 5 | 1 | 0 | 5 | 76 | 21 | 55 | 72% | 3-3 | 5.58 | 1.38 |
| 2012-06-15 | Brian Matusz | L | 25 | L 2-4 | @ ATL | 13 | 65 | L | 5.2 | 9 | 4 | 4 | 2 | 3 | 7 | 115 | 46 | 69 | 60% | 5-7 | 4.94 | 1.59 |
| 2012-06-16 | Jason Hammel | R | 30 | W 5-0 | @ ATL | 13 | 128 | W | 9.0 | 1 | 0 | 0 | 0 | 2 | 8 | 101 | 38 | 63 | 62% | 7-2 | 2.85 | 1.16 |
| 2012-06-17 | Wei-Yin Chen | L | 27 | W 2-0 | @ ATL | 13 | 13 | W | 7.0 | 6 | 0 | 0 | 0 | 1 | 2 | 101 | 31 | 70 | 69% | 7-2 | 3.38 | 1.30 |
| 2012-06-18 | Jake Arrieta | R | 26 | L 0-5 | @ NYN | 15 | 55 | L | 7.0 | 6 | 4 | 4 | 1 | 1 | 4 | 102 | 42 | 60 | 59% | 3-9 | 5.83 | 1.35 |
| 2012-06-19 | Tommy Hunter | R | 26 | L 0-5 | @ NYN | 13 | 68 | L | 6.1 | 7 | 5 | 5 | 1 | 1 | 3 | 88 | 32 | 56 | 64% | 3-4 | 5.73 | 1.38 |
| 2012-06-20 | Brian Matusz | L | 25 | L 3-4 | @ NYN | 14 | 66 | L | 4.2 | 7 | 3 | 3 | 0 | 2 | 2 | 95 | 32 | 63 | 66% | 5-8 | 4.97 | 1.61 |
| 2012-06-22 | Jason Hammel | R | 30 | L 2-1 | vs WAS | 14 | 129 | W | 8.0 | 5 | 1 | 0 | 0 | 0 | 10 | 95 | 27 | 68 | 72% | 8-2 | 2.60 | 1.11 |
| 2012-06-23 | Wei-Yin Chen | L | 27 | W 1-3 | vs WAS | 14 | 14 | L | 5.0 | 6 | 3 | 2 | 1 | 2 | 4 | 89 | 28 | 61 | 69% | 7-3 | 3.39 | 1.32 |
| 2012-06-24 | Jake Arrieta | R | 26 | L 2-1 | vs WAS | 16 | 56 | - | 6.0 | 5 | 1 | 1 | 0 | 1 | 5 | 103 | 40 | 63 | 61% | 3-9 | 5.55 | 1.33 |
| 2012-06-26 | Brian Matusz | L | 25 | W 3-7 | vs ANA | 15 | 67 | L | 5.0 | 13 | 5 | 5 | 2 | 0 | 1 | 80 | 23 | 57 | 71% | 5-9 | 5.22 | 1.67 |
| 2012-06-27 | Jason Hammel | R | 30 | W 1-13 | vs ANA | 15 | 130 | L | 3.1 | 8 | 8 | 8 | 1 | 3 | 2 | 75 | 30 | 45 | 60% | 8-3 | 3.29 | 1.19 |
| 2012-06-28 | Wei-Yin Chen | L | 27 | W 2-7 | vs CLE | 15 | 15 | L | 6.1 | 6 | 6 | 6 | 2 | 3 | 3 | 97 | 41 | 56 | 58% | 7-4 | 3.72 | 1.32 |
| 2012-06-29 | Jake Arrieta | R | 26 | L 9-8 | vs CLE | 17 | 57 | - | 3.2 | 8 | 5 | 5 | 1 | 2 | 2 | 88 | 33 | 55 | 63% | 3-9 | 5.79 | 1.38 |
| 2012-06-30 | Dana Eveland | L | 29 | W 5-11 | vs CLE | 2 | 61 | L | 3.2 | 6 | 5 | 5 | 1 | 2 | 5 | 77 | 35 | 42 | 55% | 0-1 | 4.06 | 1.35 |
| 2012-07-01 | Brian Matusz | L | 25 | W 2-6 | vs CLE | 16 | 68 | L | 4.0 | 7 | 5 | 4 | 2 | 3 | 2 | 77 | 28 | 49 | 64% | 5-10 | 5.40 | 1.71 |
| 2012-07-02 | Jason Hammel | R | 30 | L 3-6 | @ SEA | 16 | 131 | L | 6.2 | 7 | 4 | 4 | 0 | 2 | 8 | 114 | 42 | 72 | 63% | 8-4 | 3.42 | 1.20 |
| 2012-07-03 | Wei-Yin Chen | L | 27 | W 5-4 | @ SEA | 16 | 16 | - | 7.1 | 2 | 2 | 2 | 1 | 0 | 9 | 95 | 24 | 71 | 75% | 7-4 | 3.64 | 1.24 |
| 2012-07-04 | Chris Tillman | R | 24 | W 4-2 | @ SEA | 1 | 37 | W | 8.1 | 2 | 2 | 0 | 0 | 2 | 7 | 124 | 46 | 78 | 63% | 1-0 | 0.00 | 0.50 |
| 2012-07-05 | Jake Arrieta | R | 26 | L 7-9 | @ ANA | 18 | 58 | - | 3.2 | 5 | 6 | 6 | 0 | 3 | 3 | 90 | 35 | 55 | 61% | 3-9 | 6.15 | 1.42 |
| 2012-07-06 | Miguel Gonzalez | R | 28 | W 3-2 | @ ANA | 1 | 1 | W | 7.0 | 3 | 1 | 1 | 1 | 2 | 6 | 98 | 34 | 64 | 65% | 1-0 | 1.89 | 1.05 |
| 2012-07-07 | Jason Hammel | R | 30 | L 0-3 | @ ANA | 17 | 132 | L | 6.2 | 6 | 3 | 3 | 0 | 4 | 4 | 110 | 42 | 68 | 62% | 8-5 | 3.48 | 1.23 |
| 2012-07-08 | Wei-Yin Chen | L | 27 | L 0-6 | @ ANA | 17 | 17 | L | 4.0 | 5 | 5 | 5 | 3 | 3 | 5 | 72 | 26 | 46 | 64% | 7-5 | 3.93 | 1.27 |
| 2012-07-13 | Jason Hammel | R | 30 | W 2-7 | vs DET | 18 | 133 | L | 3.0 | 5 | 2 | 2 | 0 | 1 | 5 | 55 | 22 | 33 | 60% | 8-6 | 3.55 | 1.25 |
| 2012-07-14 | Wei-Yin Chen | L | 27 | L 8-6 | vs DET | 18 | 18 | - | 6.0 | 2 | 1 | 1 | 0 | 2 | 5 | 105 | 37 | 68 | 65% | 7-5 | 3.80 | 1.24 |
| 2012-07-15 | Miguel Gonzalez | R | 28 | W 0-4 | vs DET | 2 | 2 | L | 5.2 | 6 | 3 | 3 | 1 | 5 | 3 | 98 | 41 | 57 | 58% | 1-1 | 2.63 | 1.29 |
| 2012-07-16 | Chris Tillman | R | 24 | L 7-19 | @ MIN | 2 | 38 | L | 0.2 | 5 | 7 | 1 | 0 | 2 | 1 | 49 | 22 | 27 | 55% | 1-1 | 1.00 | 1.22 |
| 2012-07-17 | Zach Britton | L | 25 | L 4-6 | @ MIN | 1 | 29 | - | 4.0 | 6 | 4 | 4 | 0 | 6 | 1 | 100 | 46 | 54 | 54% | 0-0 | 9.00 | 3.00 |
| 2012-07-18 | Tommy Hunter | R | 26 | W 2-1 | @ MIN | 14 | 69 | W | 7.1 | 6 | 1 | 1 | 1 | 0 | 1 | 106 | 32 | 74 | 70% | 4-4 | 5.73 | 1.40 |
| 2012-07-19 | Wei-Yin Chen | L | 27 | W 4-3 | @ MIN | 19 | 19 | W | 7.0 | 6 | 3 | 3 | 0 | 1 | 5 | 109 | 40 | 69 | 63% | 8-5 | 3.80 | 1.22 |
| 2012-07-20 | Miguel Gonzalez | R | 28 | W 10-2 | @ CLE | 3 | 3 | W | 6.2 | 7 | 2 | 2 | 2 | 2 | 5 | 114 | 35 | 79 | 69% | 2-1 | 2.61 | 1.29 |
| 2012-07-21 | Chris Tillman | R | 24 | W 3-1 | @ CLE | 3 | 39 | W | 6.2 | 6 | 1 | 1 | 1 | 1 | 4 | 114 | 37 | 77 | 68% | 2-1 | 1.13 | 1.13 |
| 2012-07-22 | Zach Britton | L | 25 | W 4-3 | @ CLE | 2 | 30 | W | 6.0 | 4 | 0 | 0 | 0 | 2 | 5 | 106 | 41 | 65 | 61% | 1-0 | 3.60 | 1.80 |
| 2012-07-23 | Tommy Hunter | R | 26 | L 1-3 | @ CLE | 15 | 70 | L | 7.0 | 8 | 3 | 3 | 1 | 0 | 4 | 92 | 28 | 64 | 70% | 4-5 | 5.59 | 1.38 |
| 2012-07-24 | Wei-Yin Chen | L | 27 | W 1-3 | vs TBA | 20 | 20 | L | 6.2 | 4 | 3 | 3 | 1 | 3 | 5 | 109 | 36 | 73 | 67% | 8-6 | 3.80 | 1.21 |
| 2012-07-25 | Miguel Gonzalez | R | 28 | W 1-10 | vs TBA | 4 | 4 | L | 2.2 | 7 | 7 | 7 | 2 | 2 | 2 | 75 | 31 | 44 | 59% | 2-2 | 4.24 | 1.44 |
| 2012-07-26 | Chris Tillman | R | 24 | L 6-2 | vs TBA | 4 | 40 | W | 6.0 | 5 | 2 | 2 | 0 | 4 | 5 | 100 | 39 | 61 | 61% | 3-1 | 1.64 | 1.23 |
| 2012-07-27 | Zach Britton | L | 25 | W 9-14 | vs OAK | 3 | 31 | - | 5.2 | 6 | 6 | 6 | 2 | 3 | 2 | 101 | 45 | 56 | 55% | 1-0 | 5.63 | 1.69 |
| 2012-07-28 | Tommy Hunter | R | 26 | W 1-6 | vs OAK | 16 | 71 | L | 5.1 | 7 | 5 | 5 | 2 | 1 | 7 | 95 | 34 | 61 | 64% | 4-6 | 5.70 | 1.38 |
| 2012-07-29 | Wei-Yin Chen | L | 27 | L 6-1 | vs OAK | 21 | 21 | W | 5.2 | 3 | 1 | 0 | 0 | 4 | 12 | 108 | 33 | 75 | 69% | 9-6 | 3.66 | 1.22 |
| 2012-07-30 | Miguel Gonzalez | R | 28 | W 5-4 | @ NYA | 5 | 5 | W | 6.2 | 6 | 4 | 4 | 3 | 0 | 8 | 115 | 41 | 74 | 64% | 3-2 | 4.50 | 1.38 |
| 2012-07-31 | Chris Tillman | R | 24 | W 11-5 | @ NYA | 5 | 41 | W | 5.0 | 8 | 5 | 4 | 1 | 0 | 3 | 95 | 36 | 59 | 62% | 4-1 | 2.67 | 1.30 |
| 2012-08-01 | Zach Britton | L | 25 | L 3-12 | @ NYA | 4 | 32 | L | 2.2 | 7 | 7 | 7 | 1 | 3 | 3 | 80 | 37 | 43 | 54% | 1-1 | 8.50 | 2.06 |
| 2012-08-03 | Tommy Hunter | R | 26 | L 0-2 | @ TBA | 17 | 72 | L | 5.2 | 6 | 2 | 2 | 2 | 1 | 3 | 80 | 26 | 54 | 68% | 4-7 | 5.55 | 1.37 |
| 2012-08-04 | Wei-Yin Chen | L | 27 | W 4-0 | @ TBA | 22 | 22 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 4 | 104 | 31 | 73 | 70% | 10-6 | 3.47 | 1.20 |
| 2012-08-05 | Miguel Gonzalez | R | 28 | W 1-0 | @ TBA | 6 | 6 | - | 7.0 | 2 | 0 | 0 | 0 | 4 | 4 | 106 | 46 | 60 | 57% | 3-2 | 3.83 | 1.30 |
| 2012-08-06 | Chris Tillman | R | 24 | L 3-1 | vs SEA | 6 | 42 | W | 7.1 | 5 | 1 | 1 | 0 | 1 | 5 | 98 | 31 | 67 | 68% | 5-1 | 2.38 | 1.21 |
| 2012-08-07 | Zach Britton | L | 25 | L 8-7 | vs SEA | 5 | 33 | - | 5.0 | 8 | 7 | 4 | 2 | 2 | 6 | 82 | 37 | 45 | 55% | 1-1 | 8.22 | 2.04 |
| 2012-08-08 | Steve Johnson | R | 25 | L 9-2 | vs SEA | 1 | 1 | W | 6.0 | 5 | 2 | 2 | 1 | 2 | 9 | 95 | 30 | 65 | 68% | 1-0 | 3.38 | 1.25 |
| 2012-08-09 | Wei-Yin Chen | L | 27 | W 2-8 | vs KCA | 23 | 23 | L | 4.2 | 9 | 7 | 7 | 2 | 1 | 5 | 85 | 29 | 56 | 66% | 10-7 | 3.79 | 1.23 |
| 2012-08-10 | Miguel Gonzalez | R | 28 | L 7-1 | vs KCA | 7 | 7 | W | 8.0 | 6 | 1 | 1 | 1 | 1 | 5 | 102 | 35 | 67 | 66% | 4-2 | 3.44 | 1.24 |
| 2012-08-11 | Chris Tillman | R | 24 | W 3-7 | vs KCA | 7 | 43 | L | 5.2 | 6 | 6 | 6 | 3 | 2 | 5 | 103 | 49 | 54 | 52% | 5-2 | 3.38 | 1.23 |
| 2012-08-12 | Tommy Hunter | R | 26 | L 5-3 | vs KCA | 18 | 73 | - | 5.0 | 8 | 3 | 3 | 1 | 2 | 2 | 92 | 34 | 58 | 63% | 4-7 | 5.54 | 1.40 |
| 2012-08-14 | Wei-Yin Chen | L | 27 | L 7-1 | vs BOS | 24 | 24 | W | 6.0 | 9 | 1 | 1 | 0 | 1 | 4 | 95 | 24 | 71 | 75% | 11-7 | 3.70 | 1.25 |
| 2012-08-15 | Miguel Gonzalez | R | 28 | L 5-3 | vs BOS | 8 | 8 | W | 6.0 | 6 | 2 | 2 | 0 | 1 | 2 | 94 | 26 | 68 | 72% | 5-2 | 3.39 | 1.23 |
| 2012-08-16 | Chris Tillman | R | 24 | W 3-6 | vs BOS | 8 | 44 | - | 4.2 | 6 | 3 | 3 | 0 | 2 | 5 | 109 | 46 | 63 | 58% | 5-2 | 3.68 | 1.30 |
| 2012-08-17 | Tommy Hunter | R | 26 | L 3-5 | @ DET | 19 | 74 | - | 6.0 | 5 | 3 | 3 | 2 | 2 | 3 | 98 | 36 | 62 | 63% | 4-7 | 5.49 | 1.39 |
| 2012-08-18 | Zach Britton | L | 25 | W 3-2 | @ DET | 6 | 34 | W | 7.0 | 6 | 0 | 0 | 0 | 3 | 5 | 102 | 44 | 58 | 57% | 2-1 | 6.30 | 1.87 |
| 2012-08-19 | Wei-Yin Chen | L | 27 | W 7-5 | @ DET | 25 | 25 | W | 5.0 | 7 | 5 | 5 | 2 | 2 | 4 | 98 | 39 | 59 | 60% | 12-7 | 3.87 | 1.26 |
| 2012-08-20 | Miguel Gonzalez | R | 28 | L 1-5 | @ TEX | 9 | 9 | L | 5.0 | 8 | 4 | 4 | 0 | 3 | 2 | 99 | 40 | 59 | 60% | 5-3 | 3.68 | 1.30 |
| 2012-08-21 | Chris Tillman | R | 24 | W 5-3 | @ TEX | 9 | 45 | W | 6.2 | 6 | 3 | 3 | 2 | 1 | 7 | 102 | 39 | 63 | 62% | 6-2 | 3.71 | 1.25 |
| 2012-08-22 | Tommy Hunter | R | 26 | L 3-12 | @ TEX | 20 | 75 | L | 3.0 | 8 | 8 | 8 | 3 | 2 | 0 | 71 | 29 | 42 | 59% | 4-8 | 5.95 | 1.44 |
| 2012-08-24 | Zach Britton | L | 25 | L 6-4 | vs TOR | 7 | 35 | W | 6.2 | 4 | 2 | 2 | 0 | 2 | 6 | 101 | 42 | 59 | 58% | 3-1 | 5.59 | 1.68 |
| 2012-08-25 | Steve Johnson | R | 25 | L 8-2 | vs TOR | 2 | 2 | W | 6.0 | 4 | 2 | 2 | 1 | 2 | 7 | 95 | 39 | 56 | 59% | 2-0 | 3.18 | 1.12 |
| 2012-08-27 | Wei-Yin Chen | L | 27 | L 4-3 | vs CHA | 26 | 26 | - | 6.0 | 4 | 2 | 1 | 1 | 1 | 8 | 100 | 31 | 69 | 69% | 12-7 | 3.78 | 1.25 |
| 2012-08-28 | Chris Tillman | R | 24 | L 6-0 | vs CHA | 10 | 46 | W | 7.0 | 1 | 0 | 0 | 0 | 4 | 5 | 107 | 42 | 65 | 61% | 7-2 | 3.26 | 1.19 |
| 2012-08-29 | Joe Saunders | L | 31 | W 1-8 | vs CHA | 22 | 183 | L | 5.1 | 10 | 7 | 6 | 0 | 2 | 4 | 98 | 37 | 61 | 62% | 6-11 | 4.47 | 1.40 |
| 2012-08-30 | Zach Britton | L | 25 | L 5-3 | vs CHA | 8 | 36 | W | 8.0 | 7 | 1 | 1 | 0 | 0 | 10 | 104 | 27 | 77 | 74% | 4-1 | 4.80 | 1.53 |
| 2012-08-31 | Miguel Gonzalez | R | 28 | W 6-1 | @ NYA | 10 | 10 | W | 7.0 | 4 | 0 | 0 | 0 | 1 | 9 | 99 | 33 | 66 | 67% | 6-3 | 3.33 | 1.25 |
| 2012-09-01 | Wei-Yin Chen | L | 27 | L 3-4 | @ NYA | 27 | 27 | L | 6.2 | 4 | 4 | 3 | 1 | 2 | 4 | 100 | 34 | 66 | 66% | 12-8 | 3.79 | 1.23 |
| 2012-09-02 | Chris Tillman | R | 24 | W 8-3 | @ NYA | 11 | 47 | - | 3.0 | 2 | 2 | 2 | 1 | 2 | 2 | 46 | 22 | 24 | 52% | 7-2 | 3.39 | 1.20 |
| 2012-09-03 | Joe Saunders | L | 31 | W 4-0 | @ TOR | 23 | 184 | W | 6.1 | 3 | 0 | 0 | 0 | 2 | 2 | 94 | 38 | 56 | 60% | 7-11 | 4.25 | 1.37 |
| 2012-09-04 | Zach Britton | L | 25 | W 12-0 | @ TOR | 9 | 37 | W | 7.0 | 4 | 0 | 0 | 0 | 2 | 8 | 108 | 43 | 65 | 60% | 5-1 | 4.15 | 1.44 |
| 2012-09-05 | Miguel Gonzalez | R | 28 | L 4-6 | @ TOR | 11 | 11 | L | 6.1 | 7 | 5 | 5 | 1 | 0 | 4 | 94 | 26 | 68 | 72% | 6-4 | 3.60 | 1.23 |
| 2012-09-06 | Jason Hammel | R | 30 | L 10-6 | vs NYA | 19 | 134 | - | 5.0 | 6 | 1 | 1 | 0 | 2 | 6 | 80 | 28 | 52 | 65% | 8-6 | 3.47 | 1.26 |
| 2012-09-07 | Wei-Yin Chen | L | 27 | W 5-8 | vs NYA | 28 | 28 | L | 4.2 | 6 | 7 | 7 | 3 | 1 | 4 | 67 | 25 | 42 | 63% | 12-9 | 4.07 | 1.24 |
| 2012-09-08 | Joe Saunders | L | 31 | L 5-4 | vs NYA | 24 | 185 | W | 5.1 | 5 | 2 | 2 | 0 | 2 | 2 | 100 | 36 | 64 | 64% | 8-11 | 4.22 | 1.37 |
| 2012-09-09 | Zach Britton | L | 25 | W 3-13 | vs NYA | 10 | 38 | L | 3.1 | 5 | 5 | 5 | 0 | 5 | 2 | 78 | 41 | 37 | 47% | 5-2 | 4.75 | 1.55 |
| 2012-09-11 | Jason Hammel | R | 30 | L 9-2 | vs TBA | 20 | 135 | - | 3.2 | 1 | 1 | 1 | 1 | 1 | 1 | 43 | 18 | 25 | 58% | 8-6 | 3.43 | 1.24 |
| 2012-09-12 | Miguel Gonzalez | R | 28 | L 3-2 | vs TBA | 12 | 12 | - | 6.0 | 6 | 2 | 2 | 1 | 5 | 4 | 104 | 38 | 66 | 63% | 6-4 | 3.56 | 1.27 |
| 2012-09-13 | Wei-Yin Chen | L | 27 | L 3-2 | vs TBA | 29 | 29 | - | 7.1 | 8 | 2 | 2 | 0 | 1 | 7 | 104 | 27 | 77 | 74% | 12-9 | 3.99 | 1.24 |
| 2012-09-14 | Joe Saunders | L | 31 | L 2-3 | @ OAK | 25 | 186 | L | 6.0 | 7 | 3 | 3 | 1 | 2 | 6 | 103 | 40 | 63 | 61% | 8-12 | 4.24 | 1.37 |
| 2012-09-15 | Zach Britton | L | 25 | L 2-5 | @ OAK | 11 | 39 | L | 4.0 | 4 | 5 | 5 | 1 | 4 | 4 | 89 | 42 | 47 | 53% | 5-3 | 5.19 | 1.58 |
| 2012-09-16 | Randy Wolf | L | 36 | W 9-5 | @ OAK | 25 | 367 | - | 4.0 | 6 | 2 | 2 | 1 | 2 | 4 | 71 | 27 | 44 | 62% | 5-10 | 5.65 | 1.56 |
| 2012-09-17 | Chris Tillman | R | 24 | W 10-4 | @ SEA | 12 | 48 | W | 6.0 | 3 | 1 | 1 | 1 | 0 | 4 | 90 | 33 | 57 | 63% | 8-2 | 3.22 | 1.13 |
| 2012-09-18 | Wei-Yin Chen | L | 27 | W 4-2 | @ SEA | 30 | 30 | - | 5.1 | 6 | 2 | 2 | 1 | 2 | 2 | 103 | 31 | 72 | 70% | 12-9 | 3.98 | 1.25 |
| 2012-09-19 | Joe Saunders | L | 31 | W 3-1 | @ SEA | 26 | 187 | - | 8.0 | 5 | 1 | 1 | 1 | 0 | 2 | 97 | 37 | 60 | 62% | 8-12 | 4.08 | 1.34 |
| 2012-09-21 | Miguel Gonzalez | R | 28 | W 4-2 | @ BOS | 13 | 13 | W | 6.1 | 7 | 2 | 2 | 0 | 1 | 3 | 101 | 29 | 72 | 71% | 7-4 | 3.52 | 1.27 |
| 2012-09-22 | Randy Wolf | L | 36 | W 9-6 | @ BOS | 26 | 368 | - | 5.0 | 7 | 3 | 3 | 1 | 2 | 2 | 89 | 40 | 49 | 55% | 5-10 | 5.64 | 1.57 |
| 2012-09-23 | Chris Tillman | R | 24 | L 1-2 | @ BOS | 13 | 49 | - | 6.0 | 6 | 1 | 1 | 0 | 1 | 4 | 105 | 40 | 65 | 62% | 8-2 | 3.08 | 1.14 |
| 2012-09-24 | Steve Johnson | R | 25 | L 4-1 | vs TOR | 3 | 3 | W | 5.0 | 3 | 0 | 0 | 0 | 3 | 6 | 96 | 36 | 60 | 63% | 4-0 | 1.64 | 1.03 |
| 2012-09-24 | Wei-Yin Chen | L | 27 | W 5-9 | vs TOR | 31 | 31 | L | 5.0 | 9 | 5 | 5 | 2 | 1 | 3 | 81 | 28 | 53 | 65% | 12-10 | 4.11 | 1.27 |
| 2012-09-25 | Joe Saunders | L | 31 | W 0-4 | vs TOR | 27 | 188 | L | 6.1 | 11 | 4 | 3 | 0 | 0 | 2 | 93 | 32 | 61 | 66% | 8-13 | 4.10 | 1.35 |
| 2012-09-26 | Miguel Gonzalez | R | 28 | L 12-2 | vs TOR | 14 | 14 | W | 7.0 | 5 | 2 | 2 | 1 | 1 | 1 | 96 | 26 | 70 | 73% | 8-4 | 3.45 | 1.24 |
| 2012-09-28 | Chris Tillman | R | 24 | L 9-1 | vs BOS | 14 | 50 | W | 8.0 | 1 | 1 | 0 | 0 | 2 | 4 | 99 | 32 | 67 | 68% | 9-2 | 2.78 | 1.06 |
| 2012-09-29 | Steve Johnson | R | 25 | L 4-3 | vs BOS | 4 | 4 | - | 5.0 | 4 | 3 | 3 | 1 | 3 | 3 | 88 | 34 | 54 | 61% | 4-0 | 2.13 | 1.08 |
| 2012-09-30 | Joe Saunders | L | 31 | L 6-3 | vs BOS | 28 | 189 | W | 7.1 | 8 | 3 | 3 | 2 | 0 | 5 | 89 | 26 | 63 | 71% | 9-13 | 4.06 | 1.34 |
| 2012-10-01 | Wei-Yin Chen | L | 27 | L 3-5 | @ TBA | 32 | 32 | L | 6.2 | 6 | 4 | 1 | 1 | 1 | 4 | 99 | 30 | 69 | 70% | 12-11 | 4.01 | 1.26 |
| 2012-10-02 | Miguel Gonzalez | R | 28 | W 1-0 | @ TBA | 15 | 15 | W | 6.1 | 2 | 0 | 0 | 0 | 2 | 7 | 100 | 37 | 63 | 63% | 9-4 | 3.26 | 1.21 |
| 2012-10-03 | Chris Tillman | R | 24 | L 1-4 | @ TBA | 15 | 51 | L | 5.0 | 4 | 3 | 3 | 3 | 0 | 5 | 83 | 32 | 51 | 61% | 9-3 | 2.93 | 1.05 |