| West | W | L | Pct | GB |
| Texas | 93 | 69 | .574 | -- |
| LA Angels | 89 | 73 | .549 | 4.0 |
| Oakland | 64 | 68 | .485 | 15.0 |
| Seattle | 75 | 87 | .463 | 18.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-03-28 | Felix Hernandez | R | 26 | W 3-1 | @ OAK | 1 | 206 | - | 8.0 | 5 | 1 | 1 | 0 | 0 | 6 | 107 | 40 | 67 | 63% | 0-0 | 1.13 | 0.63 |
| 2012-03-29 | Jason Vargas | L | 29 | L 1-4 | @ OAK | 1 | 99 | - | 6.1 | 2 | 1 | 1 | 0 | 2 | 3 | 86 | 31 | 55 | 64% | 0-0 | 1.50 | 0.67 |
| 2012-04-06 | Jason Vargas | L | 29 | W 7-3 | @ OAK | 2 | 100 | W | 5.1 | 5 | 2 | 2 | 1 | 1 | 3 | 90 | 33 | 57 | 63% | 1-0 | 2.25 | 0.83 |
| 2012-04-07 | Felix Hernandez | R | 26 | W 8-7 | @ OAK | 2 | 207 | W | 6.1 | 8 | 6 | 6 | 1 | 1 | 7 | 103 | 39 | 64 | 62% | 1-0 | 4.50 | 1.00 |
| 2012-04-09 | Hector Noesi | R | 25 | L 5-11 | @ TEX | 1 | 3 | L | 3.0 | 6 | 7 | 7 | 2 | 3 | 3 | 85 | 35 | 50 | 59% | 0-1 | 21.00 | 3.00 |
| 2012-04-10 | Blake Beavan | R | 23 | L 0-1 | @ TEX | 1 | 16 | L | 6.1 | 6 | 1 | 1 | 0 | 1 | 3 | 93 | 35 | 58 | 62% | 0-1 | 1.50 | 1.17 |
| 2012-04-11 | Kevin Millwood | R | 37 | W 4-3 | @ TEX | 1 | 416 | - | 6.0 | 4 | 1 | 1 | 0 | 3 | 7 | 101 | 42 | 59 | 58% | 0-0 | 1.50 | 1.17 |
| 2012-04-12 | Jason Vargas | L | 29 | L 3-5 | @ TEX | 3 | 101 | L | 6.2 | 7 | 4 | 4 | 1 | 1 | 6 | 100 | 34 | 66 | 66% | 1-1 | 3.50 | 1.00 |
| 2012-04-13 | Felix Hernandez | R | 26 | W 0-4 | vs OAK | 3 | 208 | L | 7.0 | 7 | 2 | 2 | 0 | 3 | 6 | 106 | 38 | 68 | 64% | 1-1 | 3.86 | 1.14 |
| 2012-04-14 | Hector Noesi | R | 25 | L 4-0 | vs OAK | 2 | 4 | W | 8.0 | 5 | 0 | 0 | 0 | 1 | 6 | 104 | 37 | 67 | 64% | 1-1 | 5.73 | 1.36 |
| 2012-04-15 | Blake Beavan | R | 23 | L 5-3 | vs OAK | 2 | 17 | W | 7.0 | 6 | 3 | 3 | 1 | 0 | 4 | 98 | 31 | 67 | 68% | 1-1 | 2.77 | 1.00 |
| 2012-04-17 | Kevin Millwood | R | 37 | W 8-9 | vs CLE | 2 | 417 | - | 4.0 | 9 | 7 | 6 | 1 | 1 | 1 | 83 | 31 | 52 | 63% | 0-0 | 6.30 | 1.70 |
| 2012-04-18 | Jason Vargas | L | 29 | L 4-1 | vs CLE | 4 | 102 | W | 7.0 | 4 | 1 | 1 | 0 | 3 | 7 | 106 | 42 | 64 | 60% | 2-1 | 2.88 | 1.00 |
| 2012-04-19 | Felix Hernandez | R | 26 | W 1-2 | vs CLE | 4 | 209 | - | 8.0 | 5 | 0 | 0 | 0 | 1 | 12 | 125 | 51 | 74 | 59% | 1-1 | 2.79 | 1.03 |
| 2012-04-20 | Hector Noesi | R | 25 | W 3-7 | vs CHA | 3 | 5 | L | 1.1 | 6 | 6 | 6 | 1 | 2 | 1 | 58 | 19 | 39 | 67% | 1-2 | 9.75 | 1.92 |
| 2012-04-21 | Blake Beavan | R | 23 | W 0-4 | vs CHA | 3 | 18 | L | 6.0 | 7 | 3 | 3 | 1 | 1 | 1 | 101 | 31 | 70 | 69% | 1-2 | 3.32 | 1.11 |
| 2012-04-22 | Kevin Millwood | R | 37 | W 4-7 | vs CHA | 3 | 418 | L | 5.1 | 8 | 5 | 5 | 0 | 2 | 3 | 92 | 38 | 54 | 59% | 0-1 | 7.20 | 1.80 |
| 2012-04-24 | Jason Vargas | L | 29 | W 7-4 | @ DET | 5 | 103 | W | 6.0 | 6 | 4 | 4 | 2 | 1 | 4 | 94 | 33 | 61 | 65% | 3-1 | 3.48 | 1.03 |
| 2012-04-25 | Felix Hernandez | R | 26 | W 9-1 | @ DET | 5 | 210 | W | 7.0 | 4 | 1 | 1 | 1 | 3 | 2 | 95 | 41 | 54 | 57% | 2-1 | 2.50 | 1.03 |
| 2012-04-26 | Hector Noesi | R | 25 | W 5-4 | @ DET | 4 | 6 | - | 5.0 | 5 | 4 | 4 | 1 | 1 | 2 | 77 | 28 | 49 | 64% | 1-2 | 9.00 | 1.71 |
| 2012-04-27 | Blake Beavan | R | 23 | W 9-5 | @ TOR | 4 | 19 | - | 5.2 | 7 | 3 | 3 | 1 | 0 | 4 | 99 | 34 | 65 | 66% | 1-2 | 3.60 | 1.12 |
| 2012-04-28 | Kevin Millwood | R | 37 | L 0-7 | @ TOR | 4 | 419 | L | 7.0 | 7 | 3 | 1 | 0 | 2 | 4 | 99 | 41 | 58 | 59% | 0-2 | 5.32 | 1.64 |
| 2012-04-29 | Jason Vargas | L | 29 | L 2-7 | @ TOR | 6 | 104 | L | 6.0 | 4 | 2 | 2 | 1 | 3 | 4 | 116 | 54 | 62 | 53% | 3-2 | 3.41 | 1.05 |
| 2012-04-30 | Felix Hernandez | R | 26 | L 2-3 | @ TBA | 6 | 211 | - | 8.0 | 5 | 1 | 1 | 0 | 4 | 9 | 109 | 36 | 73 | 67% | 2-1 | 2.25 | 1.05 |
| 2012-05-01 | Hector Noesi | R | 25 | L 1-3 | @ TBA | 5 | 7 | L | 5.2 | 3 | 3 | 3 | 1 | 3 | 1 | 84 | 39 | 45 | 54% | 1-3 | 7.83 | 1.52 |
| 2012-05-02 | Blake Beavan | R | 23 | L 4-5 | @ TBA | 5 | 20 | L | 5.1 | 7 | 5 | 5 | 2 | 2 | 1 | 88 | 37 | 51 | 58% | 1-3 | 4.50 | 1.23 |
| 2012-05-03 | Kevin Millwood | R | 37 | L 3-4 | @ TBA | 5 | 420 | L | 6.1 | 7 | 4 | 4 | 1 | 2 | 4 | 104 | 41 | 63 | 61% | 0-3 | 5.28 | 1.55 |
| 2012-05-04 | Jason Vargas | L | 29 | W 2-3 | vs MIN | 7 | 105 | - | 6.1 | 4 | 1 | 1 | 0 | 2 | 5 | 102 | 40 | 62 | 61% | 3-2 | 3.07 | 1.02 |
| 2012-05-05 | Felix Hernandez | R | 26 | L 7-0 | vs MIN | 7 | 212 | W | 8.0 | 1 | 0 | 0 | 0 | 2 | 9 | 107 | 36 | 71 | 66% | 3-1 | 1.90 | 0.94 |
| 2012-05-06 | Hector Noesi | R | 25 | L 5-2 | vs MIN | 6 | 8 | W | 7.0 | 4 | 1 | 1 | 1 | 3 | 5 | 104 | 32 | 72 | 69% | 2-3 | 6.30 | 1.40 |
| 2012-05-07 | Blake Beavan | R | 23 | L 3-2 | vs DET | 6 | 21 | - | 3.0 | 4 | 1 | 1 | 0 | 0 | 1 | 39 | 10 | 29 | 74% | 1-3 | 4.36 | 1.24 |
| 2012-05-08 | Kevin Millwood | R | 37 | W 4-6 | vs DET | 6 | 421 | L | 5.0 | 8 | 5 | 5 | 0 | 5 | 3 | 96 | 43 | 53 | 55% | 0-4 | 5.82 | 1.71 |
| 2012-05-09 | Jason Vargas | L | 29 | L 2-1 | vs DET | 8 | 106 | W | 8.0 | 5 | 1 | 1 | 0 | 0 | 6 | 90 | 24 | 66 | 73% | 4-2 | 2.77 | 0.96 |
| 2012-05-11 | Felix Hernandez | R | 26 | L 2-6 | @ NYA | 8 | 213 | L | 6.2 | 11 | 4 | 4 | 1 | 2 | 7 | 105 | 39 | 66 | 63% | 3-2 | 2.29 | 1.05 |
| 2012-05-12 | Hector Noesi | R | 25 | L 2-6 | @ NYA | 7 | 9 | L | 7.0 | 6 | 5 | 5 | 2 | 0 | 4 | 97 | 30 | 67 | 69% | 2-4 | 6.32 | 1.30 |
| 2012-05-13 | Kevin Millwood | R | 37 | W 6-2 | @ NYA | 7 | 422 | W | 7.0 | 3 | 1 | 1 | 0 | 4 | 6 | 90 | 35 | 55 | 61% | 1-4 | 5.05 | 1.59 |
| 2012-05-14 | Jason Vargas | L | 29 | L 1-6 | @ BOS | 9 | 107 | L | 6.0 | 7 | 5 | 5 | 2 | 3 | 3 | 104 | 42 | 62 | 60% | 4-3 | 3.26 | 1.03 |
| 2012-05-15 | Blake Beavan | R | 23 | L 0-5 | @ BOS | 7 | 22 | L | 4.0 | 5 | 3 | 3 | 1 | 2 | 4 | 93 | 36 | 57 | 61% | 1-4 | 4.62 | 1.30 |
| 2012-05-16 | Felix Hernandez | R | 26 | L 3-9 | @ CLE | 9 | 214 | L | 3.2 | 10 | 8 | 6 | 0 | 3 | 3 | 113 | 50 | 63 | 56% | 3-3 | 3.00 | 1.19 |
| 2012-05-17 | Hector Noesi | R | 25 | L 5-6 | @ CLE | 8 | 10 | - | 6.1 | 5 | 1 | 1 | 0 | 3 | 5 | 100 | 34 | 66 | 66% | 2-4 | 5.65 | 1.30 |
| 2012-05-18 | Kevin Millwood | R | 37 | W 4-0 | @ COL | 8 | 423 | W | 9.0 | 2 | 0 | 0 | 0 | 1 | 7 | 112 | 38 | 74 | 66% | 2-4 | 4.14 | 1.36 |
| 2012-05-19 | Jason Vargas | L | 29 | W 10-3 | @ COL | 10 | 108 | W | 7.0 | 5 | 3 | 3 | 1 | 1 | 1 | 93 | 29 | 64 | 69% | 5-3 | 3.32 | 1.02 |
| 2012-05-20 | Blake Beavan | R | 23 | W 6-4 | @ COL | 8 | 23 | W | 5.0 | 7 | 2 | 2 | 1 | 1 | 7 | 89 | 33 | 56 | 63% | 2-4 | 4.50 | 1.33 |
| 2012-05-21 | Felix Hernandez | R | 26 | L 6-1 | vs TEX | 10 | 215 | W | 8.0 | 6 | 1 | 1 | 1 | 2 | 7 | 110 | 39 | 71 | 65% | 4-3 | 2.79 | 1.17 |
| 2012-05-22 | Hector Noesi | R | 25 | W 1-3 | vs TEX | 9 | 11 | L | 8.0 | 3 | 3 | 3 | 0 | 2 | 7 | 102 | 36 | 66 | 65% | 2-5 | 5.29 | 1.20 |
| 2012-05-23 | Kevin Millwood | R | 37 | L 5-3 | vs TEX | 9 | 424 | W | 6.0 | 3 | 0 | 0 | 0 | 1 | 2 | 97 | 37 | 60 | 62% | 3-4 | 3.70 | 1.29 |
| 2012-05-24 | Jason Vargas | L | 29 | W 0-3 | vs ANA | 11 | 109 | L | 7.0 | 7 | 3 | 3 | 1 | 0 | 6 | 105 | 35 | 70 | 67% | 5-4 | 3.38 | 1.01 |
| 2012-05-25 | Blake Beavan | R | 23 | W 4-6 | vs ANA | 9 | 24 | - | 7.0 | 5 | 3 | 3 | 1 | 2 | 1 | 99 | 32 | 67 | 68% | 2-4 | 4.41 | 1.29 |
| 2012-05-26 | Felix Hernandez | R | 26 | W 3-5 | vs ANA | 11 | 216 | L | 6.0 | 10 | 5 | 5 | 2 | 1 | 7 | 99 | 35 | 64 | 65% | 4-4 | 3.16 | 1.22 |
| 2012-05-27 | Hector Noesi | R | 25 | W 2-4 | vs ANA | 10 | 12 | L | 8.0 | 5 | 3 | 3 | 2 | 2 | 0 | 102 | 34 | 68 | 67% | 2-6 | 5.03 | 1.15 |
| 2012-05-28 | Kevin Millwood | R | 37 | L 2-4 | @ TEX | 10 | 425 | - | 5.0 | 4 | 1 | 1 | 1 | 2 | 5 | 102 | 41 | 61 | 60% | 3-4 | 3.54 | 1.28 |
| 2012-05-29 | Jason Vargas | L | 29 | W 10-3 | @ TEX | 12 | 110 | W | 6.2 | 5 | 3 | 3 | 1 | 3 | 2 | 104 | 42 | 62 | 60% | 6-4 | 3.46 | 1.04 |
| 2012-05-30 | Blake Beavan | R | 23 | W 21-8 | @ TEX | 10 | 25 | W | 6.0 | 8 | 5 | 5 | 0 | 0 | 2 | 78 | 21 | 57 | 73% | 3-4 | 4.75 | 1.29 |
| 2012-06-01 | Felix Hernandez | R | 26 | L 4-7 | @ CHA | 12 | 217 | - | 5.0 | 5 | 4 | 4 | 3 | 4 | 6 | 88 | 39 | 49 | 56% | 4-4 | 3.40 | 1.26 |
| 2012-06-02 | Hector Noesi | R | 25 | W 10-8 | @ CHA | 11 | 13 | - | 4.1 | 7 | 6 | 6 | 3 | 0 | 5 | 72 | 20 | 52 | 72% | 2-6 | 5.48 | 1.17 |
| 2012-06-03 | Kevin Millwood | R | 37 | L 2-4 | @ CHA | 11 | 426 | L | 4.0 | 7 | 4 | 4 | 0 | 5 | 4 | 99 | 40 | 59 | 60% | 3-5 | 3.88 | 1.38 |
| 2012-06-04 | Jason Vargas | L | 29 | W 8-6 | @ ANA | 13 | 111 | W | 5.2 | 9 | 4 | 4 | 2 | 2 | 8 | 104 | 39 | 65 | 63% | 7-4 | 3.64 | 1.10 |
| 2012-06-05 | Blake Beavan | R | 23 | L 1-6 | @ ANA | 11 | 26 | L | 5.0 | 10 | 6 | 6 | 3 | 0 | 2 | 85 | 28 | 57 | 67% | 3-5 | 5.25 | 1.35 |
| 2012-06-06 | Hector Noesi | R | 25 | W 8-6 | @ ANA | 12 | 14 | - | 4.0 | 4 | 6 | 6 | 1 | 5 | 1 | 79 | 34 | 45 | 57% | 2-6 | 5.96 | 1.24 |
| 2012-06-08 | Kevin Millwood | R | 37 | L 1-0 | vs LAN | 12 | 427 | - | 6.0 | 0 | 0 | 0 | 0 | 1 | 6 | 66 | 26 | 40 | 61% | 3-5 | 3.55 | 1.28 |
| 2012-06-09 | Jason Vargas | L | 29 | W 3-8 | vs LAN | 14 | 112 | L | 6.0 | 9 | 5 | 5 | 1 | 1 | 3 | 98 | 29 | 69 | 70% | 7-5 | 3.90 | 1.13 |
| 2012-06-10 | Blake Beavan | R | 23 | W 2-8 | vs LAN | 12 | 27 | L | 2.0 | 5 | 6 | 6 | 1 | 2 | 0 | 50 | 19 | 31 | 62% | 3-6 | 5.95 | 1.42 |
| 2012-06-12 | Felix Hernandez | R | 26 | W 4-5 | vs SDN | 13 | 218 | L | 6.0 | 9 | 5 | 5 | 0 | 3 | 3 | 90 | 36 | 54 | 60% | 4-5 | 3.68 | 1.31 |
| 2012-06-13 | Hector Noesi | R | 25 | W 0-1 | vs SDN | 13 | 15 | L | 7.0 | 5 | 1 | 1 | 1 | 3 | 5 | 95 | 36 | 59 | 62% | 2-7 | 5.52 | 1.23 |
| 2012-06-14 | Erasmo Ramirez | R | 22 | W 2-6 | vs SDN | 1 | 1 | L | 5.0 | 8 | 6 | 5 | 0 | 1 | 3 | 91 | 29 | 62 | 68% | 0-1 | 4.50 | 1.38 |
| 2012-06-15 | Jason Vargas | L | 29 | W 2-4 | vs SFN | 15 | 113 | L | 8.0 | 10 | 4 | 4 | 2 | 2 | 1 | 105 | 36 | 69 | 66% | 7-6 | 3.95 | 1.16 |
| 2012-06-16 | Kevin Millwood | R | 37 | L 7-4 | vs SFN | 13 | 428 | - | 5.0 | 9 | 4 | 3 | 0 | 1 | 4 | 91 | 25 | 66 | 73% | 3-5 | 3.67 | 1.33 |
| 2012-06-17 | Felix Hernandez | R | 26 | L 2-1 | vs SFN | 14 | 219 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 7 | 110 | 34 | 76 | 69% | 4-5 | 3.51 | 1.28 |
| 2012-06-18 | Hector Noesi | R | 25 | L 1-7 | @ ARI | 14 | 16 | L | 6.0 | 9 | 6 | 5 | 0 | 2 | 5 | 94 | 34 | 60 | 64% | 2-8 | 5.67 | 1.27 |
| 2012-06-19 | Erasmo Ramirez | R | 22 | W 12-9 | @ ARI | 2 | 2 | - | 4.0 | 7 | 5 | 4 | 2 | 1 | 5 | 79 | 29 | 50 | 63% | 0-1 | 5.40 | 1.50 |
| 2012-06-20 | Jason Vargas | L | 29 | L 10-14 | @ ARI | 16 | 114 | L | 4.1 | 9 | 10 | 10 | 5 | 2 | 2 | 104 | 49 | 55 | 53% | 7-7 | 4.68 | 1.23 |
| 2012-06-22 | Kevin Millwood | R | 37 | L 5-9 | @ SDN | 14 | 429 | L | 5.0 | 8 | 8 | 5 | 0 | 3 | 3 | 94 | 43 | 51 | 54% | 3-6 | 4.00 | 1.38 |
| 2012-06-23 | Felix Hernandez | R | 26 | W 5-1 | @ SDN | 15 | 220 | W | 7.0 | 6 | 1 | 1 | 0 | 1 | 10 | 99 | 31 | 68 | 69% | 5-5 | 3.35 | 1.26 |
| 2012-06-24 | Hector Noesi | R | 25 | L 0-2 | @ SDN | 15 | 17 | L | 6.0 | 7 | 2 | 2 | 0 | 3 | 6 | 103 | 42 | 61 | 59% | 2-9 | 5.48 | 1.30 |
| 2012-06-25 | Erasmo Ramirez | R | 22 | W 0-1 | vs OAK | 3 | 3 | L | 8.0 | 3 | 1 | 1 | 1 | 1 | 10 | 102 | 31 | 71 | 70% | 0-2 | 4.18 | 1.21 |
| 2012-06-26 | Jason Vargas | L | 29 | L 3-2 | vs OAK | 17 | 115 | - | 6.2 | 3 | 2 | 2 | 1 | 2 | 10 | 102 | 38 | 64 | 63% | 7-7 | 4.54 | 1.19 |
| 2012-06-27 | Kevin Millwood | R | 38 | W 1-2 | vs OAK | 15 | 430 | - | 2.2 | 1 | 1 | 1 | 1 | 0 | 3 | 39 | 15 | 24 | 62% | 3-6 | 4.01 | 1.36 |
| 2012-06-28 | Felix Hernandez | R | 26 | L 1-0 | vs BOS | 16 | 221 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 13 | 124 | 44 | 80 | 65% | 6-5 | 3.08 | 1.22 |
| 2012-06-29 | Hector Noesi | R | 25 | W 0-5 | vs BOS | 16 | 18 | L | 5.0 | 7 | 5 | 5 | 4 | 1 | 0 | 87 | 33 | 54 | 62% | 2-10 | 5.67 | 1.32 |
| 2012-06-30 | Erasmo Ramirez | R | 22 | L 3-2 | vs BOS | 4 | 4 | - | 2.2 | 0 | 0 | 0 | 0 | 0 | 2 | 41 | 17 | 24 | 59% | 0-2 | 3.77 | 1.10 |
| 2012-07-01 | Jason Vargas | L | 29 | W 1-2 | vs BOS | 18 | 116 | - | 8.0 | 5 | 1 | 1 | 1 | 2 | 6 | 115 | 43 | 72 | 63% | 7-7 | 4.31 | 1.17 |
| 2012-07-02 | Hisashi Iwakuma | R | 31 | L 6-3 | vs BAL | 1 | 1 | - | 5.0 | 3 | 3 | 3 | 1 | 3 | 4 | 69 | 32 | 37 | 54% | 1-1 | 4.89 | 1.40 |
| 2012-07-03 | Felix Hernandez | R | 26 | W 4-5 | vs BAL | 17 | 222 | - | 5.1 | 8 | 4 | 4 | 0 | 0 | 8 | 89 | 28 | 61 | 69% | 6-5 | 3.26 | 1.23 |
| 2012-07-04 | Hector Noesi | R | 25 | W 2-4 | vs BAL | 17 | 19 | L | 5.0 | 7 | 4 | 4 | 1 | 0 | 4 | 80 | 24 | 56 | 70% | 2-11 | 5.75 | 1.32 |
| 2012-07-06 | Kevin Millwood | R | 38 | L 1-4 | @ OAK | 16 | 431 | - | 7.0 | 3 | 0 | 0 | 0 | 2 | 7 | 94 | 36 | 58 | 62% | 3-6 | 3.70 | 1.31 |
| 2012-07-07 | Jason Vargas | L | 29 | W 7-1 | @ OAK | 19 | 117 | W | 9.0 | 7 | 1 | 1 | 1 | 1 | 6 | 109 | 42 | 67 | 61% | 8-7 | 4.07 | 1.15 |
| 2012-07-08 | Felix Hernandez | R | 26 | L 1-2 | @ OAK | 18 | 223 | - | 7.2 | 6 | 1 | 1 | 0 | 3 | 6 | 115 | 48 | 67 | 58% | 6-5 | 3.12 | 1.23 |
| 2012-07-13 | Kevin Millwood | R | 38 | W 2-3 | vs TEX | 17 | 432 | L | 6.2 | 8 | 3 | 3 | 1 | 2 | 4 | 93 | 34 | 59 | 63% | 3-7 | 3.71 | 1.32 |
| 2012-07-14 | Felix Hernandez | R | 26 | L 7-0 | vs TEX | 19 | 224 | W | 9.0 | 3 | 0 | 0 | 0 | 0 | 12 | 103 | 33 | 70 | 68% | 7-5 | 2.91 | 1.17 |
| 2012-07-15 | Hisashi Iwakuma | R | 31 | W 0-4 | vs TEX | 2 | 2 | L | 5.0 | 7 | 4 | 4 | 1 | 3 | 0 | 84 | 32 | 52 | 62% | 1-2 | 5.18 | 1.48 |
| 2012-07-16 | Jason Vargas | L | 29 | W 9-4 | @ KCA | 20 | 118 | W | 6.0 | 7 | 3 | 3 | 2 | 3 | 0 | 97 | 39 | 58 | 60% | 9-7 | 4.09 | 1.17 |
| 2012-07-17 | Blake Beavan | R | 23 | W 9-6 | @ KCA | 13 | 28 | W | 6.0 | 7 | 5 | 5 | 0 | 0 | 3 | 95 | 36 | 59 | 62% | 4-6 | 6.09 | 1.40 |
| 2012-07-18 | Kevin Millwood | R | 38 | L 7-8 | @ KCA | 18 | 433 | - | 5.0 | 10 | 7 | 7 | 1 | 1 | 2 | 82 | 27 | 55 | 67% | 3-7 | 4.15 | 1.36 |
| 2012-07-19 | Felix Hernandez | R | 26 | W 6-1 | @ KCA | 20 | 225 | W | 8.0 | 8 | 1 | 1 | 0 | 1 | 3 | 89 | 24 | 65 | 73% | 8-5 | 2.81 | 1.16 |
| 2012-07-20 | Hisashi Iwakuma | R | 31 | L 3-4 | @ TBA | 3 | 3 | - | 6.0 | 6 | 2 | 2 | 1 | 1 | 7 | 91 | 30 | 61 | 67% | 1-2 | 4.89 | 1.43 |
| 2012-07-21 | Jason Vargas | L | 29 | W 2-1 | @ TBA | 21 | 119 | W | 6.0 | 7 | 1 | 0 | 0 | 3 | 5 | 108 | 41 | 67 | 62% | 10-7 | 3.91 | 1.20 |
| 2012-07-22 | Blake Beavan | R | 24 | W 2-1 | @ TBA | 14 | 29 | W | 8.0 | 4 | 1 | 1 | 0 | 0 | 5 | 100 | 31 | 69 | 69% | 5-6 | 5.57 | 1.30 |
| 2012-07-23 | Kevin Millwood | R | 38 | W 1-4 | vs NYA | 19 | 434 | L | 7.0 | 9 | 3 | 3 | 0 | 2 | 5 | 100 | 34 | 66 | 66% | 3-8 | 4.13 | 1.38 |
| 2012-07-24 | Felix Hernandez | R | 26 | L 4-2 | vs NYA | 21 | 226 | W | 7.1 | 4 | 2 | 2 | 1 | 3 | 4 | 116 | 45 | 71 | 61% | 9-5 | 2.80 | 1.16 |
| 2012-07-25 | Hisashi Iwakuma | R | 31 | W 2-5 | vs NYA | 4 | 4 | - | 5.0 | 6 | 1 | 1 | 1 | 3 | 3 | 94 | 41 | 53 | 56% | 1-2 | 4.59 | 1.47 |
| 2012-07-26 | Jason Vargas | L | 29 | L 4-1 | vs KCA | 22 | 120 | W | 8.0 | 1 | 1 | 1 | 0 | 3 | 5 | 115 | 48 | 67 | 58% | 11-7 | 3.76 | 1.16 |
| 2012-07-27 | Blake Beavan | R | 24 | L 6-1 | vs KCA | 15 | 30 | W | 6.2 | 4 | 1 | 1 | 0 | 1 | 6 | 91 | 24 | 67 | 74% | 6-6 | 5.20 | 1.25 |
| 2012-07-28 | Kevin Millwood | R | 38 | L 4-3 | vs KCA | 20 | 435 | W | 6.1 | 6 | 1 | 0 | 0 | 1 | 3 | 106 | 41 | 65 | 61% | 4-8 | 3.91 | 1.37 |
| 2012-07-29 | Felix Hernandez | R | 26 | L 7-6 | vs KCA | 22 | 227 | - | 7.0 | 5 | 2 | 2 | 0 | 2 | 6 | 101 | 37 | 64 | 63% | 9-5 | 2.79 | 1.15 |
| 2012-07-30 | Hisashi Iwakuma | R | 31 | L 4-1 | vs TOR | 5 | 5 | W | 8.0 | 4 | 1 | 1 | 1 | 3 | 13 | 107 | 31 | 76 | 71% | 2-2 | 4.12 | 1.39 |
| 2012-07-31 | Jason Vargas | L | 29 | L 7-2 | vs TOR | 23 | 121 | W | 7.0 | 5 | 2 | 2 | 0 | 1 | 4 | 103 | 33 | 70 | 68% | 12-7 | 3.71 | 1.14 |
| 2012-08-01 | Blake Beavan | R | 24 | L 5-3 | vs TOR | 16 | 31 | W | 7.2 | 7 | 3 | 3 | 2 | 0 | 4 | 75 | 17 | 58 | 77% | 7-6 | 5.04 | 1.22 |
| 2012-08-03 | Kevin Millwood | R | 38 | L 3-6 | @ NYA | 21 | 436 | L | 6.0 | 9 | 4 | 4 | 1 | 1 | 3 | 107 | 40 | 67 | 63% | 4-9 | 4.02 | 1.38 |
| 2012-08-04 | Felix Hernandez | R | 26 | W 1-0 | @ NYA | 23 | 228 | W | 9.0 | 2 | 0 | 0 | 0 | 2 | 6 | 101 | 32 | 69 | 68% | 10-5 | 2.63 | 1.11 |
| 2012-08-05 | Hisashi Iwakuma | R | 31 | L 2-6 | @ NYA | 6 | 6 | L | 5.0 | 7 | 4 | 3 | 1 | 2 | 4 | 105 | 39 | 66 | 63% | 2-3 | 4.22 | 1.42 |
| 2012-08-06 | Jason Vargas | L | 30 | L 1-3 | @ BAL | 24 | 122 | L | 8.0 | 8 | 3 | 3 | 1 | 0 | 2 | 104 | 32 | 72 | 69% | 12-8 | 3.69 | 1.14 |
| 2012-08-07 | Blake Beavan | R | 24 | L 7-8 | @ BAL | 17 | 32 | - | 6.0 | 7 | 4 | 4 | 2 | 1 | 2 | 105 | 36 | 69 | 66% | 7-6 | 5.10 | 1.23 |
| 2012-08-08 | Kevin Millwood | R | 38 | L 2-9 | @ BAL | 22 | 437 | L | 4.0 | 8 | 7 | 7 | 2 | 1 | 3 | 87 | 30 | 57 | 66% | 4-10 | 4.39 | 1.41 |
| 2012-08-10 | Felix Hernandez | R | 26 | L 5-6 | @ ANA | 24 | 229 | - | 7.0 | 5 | 5 | 4 | 1 | 1 | 3 | 107 | 41 | 66 | 62% | 10-5 | 2.74 | 1.10 |
| 2012-08-11 | Hisashi Iwakuma | R | 31 | W 7-4 | @ ANA | 7 | 7 | W | 7.0 | 6 | 3 | 3 | 1 | 1 | 4 | 86 | 28 | 58 | 67% | 3-3 | 4.18 | 1.38 |
| 2012-08-12 | Jason Vargas | L | 30 | W 4-1 | @ ANA | 25 | 123 | W | 8.1 | 7 | 1 | 1 | 0 | 1 | 5 | 98 | 28 | 70 | 71% | 13-8 | 3.57 | 1.13 |
| 2012-08-13 | Blake Beavan | R | 24 | W 1-4 | vs TBA | 18 | 33 | L | 6.0 | 8 | 4 | 4 | 1 | 0 | 4 | 97 | 34 | 63 | 65% | 7-7 | 5.16 | 1.23 |
| 2012-08-14 | Kevin Millwood | R | 38 | L 3-2 | vs TBA | 23 | 438 | - | 7.0 | 8 | 2 | 2 | 0 | 1 | 8 | 100 | 38 | 62 | 62% | 4-10 | 4.30 | 1.40 |
| 2012-08-15 | Felix Hernandez | R | 26 | L 1-0 | vs TBA | 25 | 230 | W | 9.0 | 0 | 0 | 0 | 0 | 0 | 12 | 111 | 36 | 75 | 68% | 11-5 | 2.60 | 1.04 |
| 2012-08-17 | Hisashi Iwakuma | R | 31 | L 5-3 | vs MIN | 8 | 8 | W | 7.0 | 4 | 1 | 0 | 0 | 1 | 6 | 97 | 32 | 65 | 67% | 4-3 | 3.81 | 1.32 |
| 2012-08-18 | Jason Vargas | L | 30 | L 3-2 | vs MIN | 26 | 124 | - | 6.2 | 8 | 2 | 2 | 0 | 1 | 2 | 111 | 37 | 74 | 67% | 13-8 | 3.53 | 1.14 |
| 2012-08-19 | Blake Beavan | R | 24 | L 5-1 | vs MIN | 19 | 34 | W | 5.1 | 7 | 1 | 1 | 0 | 1 | 3 | 97 | 25 | 72 | 74% | 8-7 | 5.00 | 1.25 |
| 2012-08-20 | Kevin Millwood | R | 38 | L 5-3 | vs CLE | 24 | 439 | - | 6.0 | 5 | 3 | 3 | 1 | 3 | 0 | 94 | 36 | 58 | 62% | 4-10 | 4.30 | 1.40 |
| 2012-08-21 | Felix Hernandez | R | 26 | L 5-1 | vs CLE | 26 | 231 | W | 7.2 | 7 | 1 | 1 | 0 | 1 | 5 | 105 | 35 | 70 | 67% | 12-5 | 2.54 | 1.04 |
| 2012-08-22 | Hisashi Iwakuma | R | 31 | L 3-1 | vs CLE | 9 | 9 | - | 5.2 | 6 | 1 | 1 | 0 | 3 | 5 | 89 | 31 | 58 | 65% | 4-3 | 3.64 | 1.33 |
| 2012-08-24 | Jason Vargas | L | 30 | L 8-9 | @ CHA | 27 | 125 | - | 4.0 | 7 | 6 | 6 | 3 | 1 | 2 | 76 | 25 | 51 | 67% | 13-8 | 3.75 | 1.16 |
| 2012-08-25 | Blake Beavan | R | 24 | L 4-5 | @ CHA | 20 | 35 | L | 5.0 | 7 | 4 | 4 | 1 | 3 | 2 | 80 | 29 | 51 | 64% | 8-8 | 5.10 | 1.28 |
| 2012-08-26 | Kevin Millwood | R | 38 | L 3-4 | @ CHA | 25 | 440 | L | 6.2 | 7 | 4 | 3 | 1 | 1 | 3 | 87 | 22 | 65 | 75% | 4-11 | 4.28 | 1.39 |
| 2012-08-27 | Felix Hernandez | R | 26 | W 1-0 | @ MIN | 27 | 232 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 5 | 100 | 31 | 69 | 69% | 13-5 | 2.42 | 1.03 |
| 2012-08-28 | Hisashi Iwakuma | R | 31 | W 5-2 | @ MIN | 10 | 10 | W | 6.0 | 1 | 1 | 0 | 0 | 4 | 4 | 95 | 45 | 50 | 53% | 5-3 | 3.40 | 1.30 |
| 2012-08-29 | Jason Vargas | L | 30 | L 0-10 | @ MIN | 28 | 126 | L | 4.2 | 9 | 6 | 6 | 2 | 2 | 5 | 102 | 33 | 69 | 68% | 13-9 | 3.94 | 1.18 |
| 2012-08-30 | Blake Beavan | R | 24 | W 5-4 | @ MIN | 21 | 36 | W | 7.0 | 5 | 2 | 2 | 0 | 2 | 1 | 101 | 43 | 58 | 57% | 9-8 | 4.95 | 1.27 |
| 2012-08-31 | Kevin Millwood | R | 38 | W 1-9 | vs ANA | 26 | 441 | L | 5.0 | 9 | 5 | 4 | 1 | 4 | 1 | 117 | 44 | 73 | 62% | 4-12 | 4.38 | 1.43 |
| 2012-09-01 | Felix Hernandez | R | 26 | W 2-5 | vs ANA | 28 | 233 | L | 7.1 | 9 | 5 | 4 | 0 | 2 | 7 | 118 | 33 | 85 | 72% | 13-6 | 2.51 | 1.04 |
| 2012-09-02 | Hisashi Iwakuma | R | 31 | L 2-1 | vs ANA | 11 | 11 | W | 7.1 | 5 | 0 | 0 | 0 | 0 | 7 | 101 | 25 | 76 | 75% | 6-3 | 3.15 | 1.26 |
| 2012-09-03 | Jason Vargas | L | 30 | L 4-1 | vs BOS | 29 | 127 | W | 7.0 | 6 | 1 | 1 | 0 | 0 | 5 | 100 | 31 | 69 | 69% | 14-9 | 3.84 | 1.17 |
| 2012-09-04 | Blake Beavan | R | 24 | W 3-4 | vs BOS | 22 | 37 | L | 5.2 | 8 | 4 | 4 | 2 | 0 | 1 | 85 | 30 | 55 | 65% | 9-9 | 5.00 | 1.27 |
| 2012-09-05 | Kevin Millwood | R | 38 | L 2-1 | vs BOS | 27 | 442 | W | 6.0 | 4 | 1 | 1 | 0 | 3 | 3 | 92 | 31 | 61 | 66% | 5-12 | 4.27 | 1.42 |
| 2012-09-07 | Felix Hernandez | R | 26 | W 1-6 | vs OAK | 29 | 234 | L | 4.2 | 11 | 6 | 5 | 1 | 1 | 4 | 95 | 34 | 61 | 64% | 13-7 | 2.67 | 1.08 |
| 2012-09-08 | Hisashi Iwakuma | R | 31 | W 1-6 | vs OAK | 12 | 12 | L | 3.2 | 6 | 5 | 4 | 1 | 2 | 3 | 75 | 27 | 48 | 64% | 6-4 | 3.39 | 1.29 |
| 2012-09-09 | Jason Vargas | L | 30 | W 2-4 | vs OAK | 30 | 128 | L | 7.0 | 4 | 3 | 3 | 1 | 3 | 6 | 105 | 39 | 66 | 63% | 14-10 | 3.84 | 1.17 |
| 2012-09-11 | Erasmo Ramirez | R | 22 | W 4-3 | @ TOR | 5 | 5 | W | 7.0 | 6 | 2 | 2 | 0 | 1 | 6 | 89 | 24 | 65 | 73% | 1-2 | 3.46 | 1.05 |
| 2012-09-12 | Kevin Millwood | R | 38 | W 3-2 | @ TOR | 28 | 443 | W | 5.0 | 2 | 2 | 2 | 1 | 1 | 3 | 65 | 26 | 39 | 60% | 6-12 | 4.25 | 1.39 |
| 2012-09-13 | Felix Hernandez | R | 26 | L 3-8 | @ TOR | 30 | 235 | L | 4.0 | 10 | 7 | 7 | 2 | 1 | 4 | 95 | 33 | 62 | 65% | 13-8 | 2.92 | 1.11 |
| 2012-09-14 | Hisashi Iwakuma | R | 31 | L 3-9 | @ TEX | 13 | 13 | L | 5.1 | 7 | 2 | 2 | 2 | 1 | 4 | 88 | 30 | 58 | 66% | 6-5 | 3.40 | 1.30 |
| 2012-09-15 | Jason Vargas | L | 30 | W 8-6 | @ TEX | 31 | 129 | - | 5.2 | 6 | 4 | 4 | 1 | 3 | 4 | 103 | 46 | 57 | 55% | 14-10 | 3.93 | 1.18 |
| 2012-09-16 | Blake Beavan | R | 24 | L 1-2 | @ TEX | 23 | 38 | L | 7.0 | 7 | 2 | 2 | 1 | 1 | 2 | 97 | 32 | 65 | 67% | 9-10 | 4.87 | 1.26 |
| 2012-09-17 | Hector Noesi | R | 26 | W 4-10 | vs BAL | 18 | 20 | L | 1.1 | 8 | 7 | 6 | 1 | 2 | 1 | 54 | 19 | 35 | 65% | 2-12 | 6.00 | 1.39 |
| 2012-09-18 | Erasmo Ramirez | R | 22 | W 2-4 | vs BAL | 6 | 6 | - | 8.0 | 4 | 2 | 2 | 0 | 0 | 6 | 97 | 34 | 63 | 65% | 1-2 | 3.26 | 0.96 |
| 2012-09-19 | Felix Hernandez | R | 26 | W 1-3 | vs BAL | 31 | 236 | - | 8.0 | 6 | 1 | 1 | 0 | 1 | 8 | 100 | 34 | 66 | 66% | 13-8 | 2.85 | 1.10 |
| 2012-09-21 | Hisashi Iwakuma | R | 31 | L 6-3 | vs TEX | 14 | 14 | W | 7.0 | 8 | 3 | 3 | 1 | 0 | 4 | 90 | 28 | 62 | 69% | 7-5 | 3.42 | 1.29 |
| 2012-09-22 | Blake Beavan | R | 24 | L 1-0 | vs TEX | 24 | 39 | W | 7.0 | 8 | 0 | 0 | 0 | 1 | 2 | 93 | 29 | 64 | 69% | 10-10 | 4.63 | 1.26 |
| 2012-09-23 | Jason Vargas | L | 30 | W 2-3 | vs TEX | 32 | 130 | L | 6.0 | 8 | 3 | 3 | 2 | 2 | 3 | 106 | 38 | 68 | 64% | 14-11 | 3.94 | 1.20 |
| 2012-09-25 | Erasmo Ramirez | R | 22 | L 4-5 | @ ANA | 7 | 7 | L | 6.0 | 7 | 5 | 3 | 2 | 0 | 3 | 98 | 31 | 67 | 68% | 1-3 | 3.40 | 0.98 |
| 2012-09-26 | Felix Hernandez | R | 26 | L 3-4 | @ ANA | 32 | 237 | - | 6.0 | 5 | 2 | 2 | 0 | 2 | 9 | 106 | 33 | 73 | 69% | 13-8 | 2.85 | 1.10 |
| 2012-09-27 | Hisashi Iwakuma | R | 31 | W 9-4 | @ ANA | 15 | 15 | W | 6.0 | 7 | 2 | 1 | 0 | 0 | 3 | 90 | 27 | 63 | 70% | 8-5 | 3.33 | 1.29 |
| 2012-09-28 | Blake Beavan | R | 24 | L 2-8 | @ OAK | 25 | 40 | L | 4.2 | 5 | 4 | 3 | 2 | 2 | 2 | 85 | 29 | 56 | 66% | 10-11 | 4.69 | 1.28 |
| 2012-09-29 | Jason Vargas | L | 30 | L 4-7 | @ OAK | 33 | 131 | - | 7.0 | 5 | 1 | 1 | 0 | 0 | 7 | 102 | 35 | 67 | 66% | 14-11 | 3.86 | 1.18 |
| 2012-09-30 | Erasmo Ramirez | R | 22 | L 2-5 | @ OAK | 8 | 8 | - | 6.1 | 3 | 2 | 2 | 0 | 4 | 6 | 102 | 41 | 61 | 60% | 1-3 | 3.36 | 1.00 |
| 2012-10-01 | Felix Hernandez | R | 26 | W 4-8 | vs ANA | 33 | 238 | L | 5.1 | 12 | 7 | 7 | 0 | 3 | 7 | 98 | 33 | 65 | 66% | 13-9 | 3.06 | 1.14 |
| 2012-10-02 | Hisashi Iwakuma | R | 31 | L 6-1 | vs ANA | 16 | 16 | W | 6.0 | 6 | 0 | 0 | 0 | 1 | 7 | 105 | 33 | 72 | 69% | 9-5 | 3.17 | 1.28 |
| 2012-10-03 | Blake Beavan | R | 24 | L 12-0 | vs ANA | 26 | 41 | W | 8.0 | 7 | 0 | 0 | 0 | 1 | 0 | 99 | 28 | 71 | 72% | 11-11 | 4.44 | 1.26 |