| 2012-04-06 | vs SFN | 1 | W 5-4 | 1-0 | 1 | 49,130 | Ian Kennedy | Tim Lincecum | Ian Kennedy | Tim Lincecum | J.J. Putz | 5 | 4 | 1 |
| 2012-04-07 | vs SFN | 2 | W 5-4 | 2-0 | 1 | 34,789 | Daniel Hudson | Madison Bumgarner | Daniel Hudson | Madison Bumgarner | J.J. Putz | 10 | 8 | 2 |
| 2012-04-08 | vs SFN | 3 | W 7-6 | 3-0 | 1 | 24,193 | Josh Collmenter | Matt Cain | Wade Miley | Jeremy Affeldt | Bryan Shaw | 17 | 14 | 3 |
| 2012-04-10 | @ SDN | 4 | W 4-2 | 4-0 | 1 | 18,652 | Trevor Cahill | Edinson Volquez | Craig Breslow | Micah Owings | J.J. Putz | 21 | 16 | 5 |
| 2012-04-11 | @ SDN | 5 | L 1-2 | 4-1 | 2 | 16,091 | Joe Saunders | Cory Luebke | Ernesto Frieri | David Hernandez | Huston Street | 22 | 18 | 4 |
| 2012-04-12 | @ SDN | 6 | W 3-1 | 5-1 | 2 | 20,858 | Ian Kennedy | Anthony Bass | Ian Kennedy | Micah Owings | J.J. Putz | 25 | 19 | 6 |
| 2012-04-13 | @ COL | 7 | L 6-7 | 5-2 | 2 | 30,642 | Daniel Hudson | Juan Nicasio | Rex Brothers | Bryan Shaw | Rafael Betancourt | 31 | 26 | 5 |
| 2012-04-14 | @ COL | 8 | L 7-8 | 5-3 | 2 | 29,856 | Josh Collmenter | Jhoulis Chacin | Tyler Chatwood | J.J. Putz | | 38 | 34 | 4 |
| 2012-04-15 | @ COL | 9 | W 5-2 | 6-3 | 2 | 26,952 | Trevor Cahill | Drew Pomeranz | Trevor Cahill | Drew Pomeranz | Bryan Shaw | 43 | 36 | 7 |
| 2012-04-16 | vs PIT | 10 | W 5-1 | 7-3 | 2 | 17,366 | Joe Saunders | Erik Bedard | Joe Saunders | Erik Bedard | | 48 | 37 | 11 |
| 2012-04-17 | vs PIT | 11 | L 4-5 | 7-4 | 2 | 19,198 | Ian Kennedy | Jeff Karstens | Jason Grilli | Bryan Shaw | Juan Cruz | 52 | 42 | 10 |
| 2012-04-18 | vs PIT | 12 | L 1-2 | 7-5 | 2 | 18,368 | Daniel Hudson | James McDonald | Brad Lincoln | Daniel Hudson | Juan Cruz | 53 | 44 | 9 |
| 2012-04-19 | vs ATL | 13 | W 2-10 | 8-5 | 2 | 18,110 | Josh Collmenter | Mike Minor | Mike Minor | Josh Collmenter | | 55 | 54 | 1 |
| 2012-04-20 | vs ATL | 14 | L 1-9 | 8-6 | 3 | 27,761 | Trevor Cahill | Brandon Beachy | Brandon Beachy | Trevor Cahill | | 56 | 63 | -7 |
| 2012-04-21 | vs ATL | 15 | L 2-3 | 8-7 | 3 | 30,188 | Joe Saunders | Tommy Hanson | Tommy Hanson | Joe Saunders | Craig Kimbrel | 58 | 66 | -8 |
| 2012-04-22 | vs ATL | 16 | W 6-4 | 9-7 | 3 | 28,679 | Ian Kennedy | Randall Delgado | Ian Kennedy | Randall Delgado | J.J. Putz | 64 | 70 | -6 |
| 2012-04-23 | vs PHI | 17 | W 9-5 | 10-7 | 4 | 21,195 | Wade Miley | Kyle Kendrick | Wade Miley | Kyle Kendrick | | 73 | 75 | -2 |
| 2012-04-24 | vs PHI | 18 | L 5-8 | 10-8 | 3 | 24,213 | Josh Collmenter | Vance Worley | Vance Worley | Josh Collmenter | Jonathan Papelbon | 78 | 83 | -5 |
| 2012-04-25 | vs PHI | 19 | L 2-7 | 10-9 | 3 | 25,934 | Trevor Cahill | Cole Hamels | Cole Hamels | Trevor Cahill | | 80 | 90 | -10 |
| 2012-04-27 | @ MIA | 20 | W 5-0 | 11-9 | 2 | 31,949 | Joe Saunders | Carlos Zambrano | Joe Saunders | Carlos Zambrano | | 85 | 90 | -5 |
| 2012-04-28 | @ MIA | 21 | L 2-3 | 11-10 | 3 | 33,525 | Ian Kennedy | Anibal Sanchez | Steve Cishek | Brad Ziegler | | 87 | 93 | -6 |
| 2012-04-29 | @ MIA | 22 | W 8-4 | 12-10 | 3 | 34,918 | Wade Miley | Josh Johnson | Wade Miley | Josh Johnson | | 95 | 97 | -2 |
| 2012-04-30 | @ MIA | 23 | W 9-5 | 13-10 | 3 | 31,006 | Patrick Corbin | Mark Buehrle | Patrick Corbin | Mark Buehrle | | 104 | 102 | 2 |
| 2012-05-01 | @ WAS | 24 | W 5-1 | 14-10 | 2 | 22,675 | Trevor Cahill | Jordan Zimmermann | Trevor Cahill | Jordan Zimmermann | | 109 | 103 | 6 |
| 2012-05-02 | @ WAS | 25 | L 4-5 | 14-11 | 2 | 16,274 | Joe Saunders | Edwin Jackson | Henry Rodriguez | J.J. Putz | | 113 | 108 | 5 |
| 2012-05-03 | @ WAS | 26 | L 1-2 | 14-12 | 2 | 19,656 | Ian Kennedy | Ross Detwiler | Ross Detwiler | Ian Kennedy | Henry Rodriguez | 114 | 110 | 4 |
| 2012-05-04 | @ NYN | 27 | W 5-4 | 15-12 | 2 | 26,995 | Wade Miley | Dillon Gee | Brad Ziegler | Jon Rauch | J.J. Putz | 119 | 114 | 5 |
| 2012-05-05 | @ NYN | 28 | L 3-4 | 15-13 | 2 | 30,253 | Patrick Corbin | Johan Santana | Johan Santana | Patrick Corbin | Frank Francisco | 122 | 118 | 4 |
| 2012-05-06 | @ NYN | 29 | L 1-3 | 15-14 | 3 | 29,107 | Trevor Cahill | R.A. Dickey | R.A. Dickey | Trevor Cahill | Frank Francisco | 123 | 121 | 2 |
| 2012-05-07 | vs SLN | 30 | L 6-9 | 15-15 | 3 | 26,447 | Joe Saunders | Lance Lynn | Lance Lynn | Joe Saunders | Jason Motte | 129 | 130 | -1 |
| 2012-05-08 | vs SLN | 31 | L 1-6 | 15-16 | 3 | 30,156 | Ian Kennedy | Jake Westbrook | Jake Westbrook | Ian Kennedy | | 130 | 136 | -6 |
| 2012-05-09 | vs SLN | 32 | L 2-7 | 15-17 | 3 | 27,710 | Wade Miley | Kyle Lohse | Kyle Lohse | Wade Miley | Jason Motte | 132 | 143 | -11 |
| 2012-05-11 | vs SFN | 33 | W 5-1 | 16-17 | 3 | 35,792 | Patrick Corbin | Madison Bumgarner | Patrick Corbin | Madison Bumgarner | | 137 | 144 | -7 |
| 2012-05-12 | vs SFN | 34 | L 2-5 | 16-18 | 3 | 31,719 | Trevor Cahill | Matt Cain | Matt Cain | Trevor Cahill | Santiago Casilla | 139 | 149 | -10 |
| 2012-05-13 | vs SFN | 35 | L 3-7 | 16-19 | 3 | 35,430 | Joe Saunders | Barry Zito | Barry Zito | Joe Saunders | | 142 | 156 | -14 |
| 2012-05-14 | @ LAN | 36 | L 1-3 | 16-20 | 3 | 24,312 | Ian Kennedy | Clayton Kershaw | Clayton Kershaw | Ian Kennedy | Kenley Jansen | 143 | 159 | -16 |
| 2012-05-15 | @ LAN | 37 | W 5-1 | 17-20 | 3 | 47,077 | Wade Miley | Chad Billingsley | Wade Miley | Chad Billingsley | | 148 | 160 | -12 |
| 2012-05-16 | @ COL | 38 | L 1-6 | 17-21 | 3 | 32,162 | Patrick Corbin | Jamie Moyer | Jamie Moyer | Patrick Corbin | | 149 | 166 | -17 |
| 2012-05-17 | @ COL | 39 | W 9-7 | 18-21 | 3 | 32,035 | Trevor Cahill | Juan Nicasio | Brad Ziegler | Rafael Betancourt | J.J. Putz | 158 | 173 | -15 |
| 2012-05-18 | @ KCA | 40 | W 6-4 | 19-21 | 3 | 33,694 | Joe Saunders | Luis Mendoza | Brad Ziegler | Kelvin Herrera | J.J. Putz | 164 | 177 | -13 |
| 2012-05-19 | @ KCA | 41 | L 3-7 | 19-22 | 3 | 27,469 | Ian Kennedy | Bruce Chen | Bruce Chen | Ian Kennedy | | 167 | 184 | -17 |
| 2012-05-20 | @ KCA | 42 | W 2-0 | 20-22 | 3 | 24,234 | Wade Miley | Nathan Adcock | Wade Miley | Nathan Adcock | J.J. Putz | 169 | 184 | -15 |
| 2012-05-21 | vs LAN | 43 | L 1-6 | 20-23 | 3 | 24,768 | Patrick Corbin | Chris Capuano | Chris Capuano | Patrick Corbin | | 170 | 190 | -20 |
| 2012-05-22 | vs LAN | 44 | L 7-8 | 20-24 | 3 | 25,738 | Trevor Cahill | Aaron Harang | Josh Lindblom | J.J. Putz | Kenley Jansen | 177 | 198 | -21 |
| 2012-05-23 | vs LAN | 45 | L 11-4 | 20-25 | 3 | 27,645 | Joe Saunders | Ted Lilly | Joe Saunders | Ted Lilly | | 188 | 202 | -14 |
| 2012-05-25 | vs MIL | 46 | L 1-7 | 20-26 | 3 | 35,478 | Ian Kennedy | Yovani Gallardo | Yovani Gallardo | Ian Kennedy | | 189 | 209 | -20 |
| 2012-05-26 | vs MIL | 47 | W 8-5 | 21-26 | 3 | 30,184 | Wade Miley | Zack Greinke | Wade Miley | Zack Greinke | J.J. Putz | 197 | 214 | -17 |
| 2012-05-27 | vs MIL | 48 | W 4-3 | 22-26 | 3 | 33,481 | Daniel Hudson | Randy Wolf | Bryan Shaw | Jose Veras | J.J. Putz | 201 | 217 | -16 |
| 2012-05-28 | @ SFN | 49 | L 2-4 | 22-27 | 3 | 42,295 | Trevor Cahill | Barry Zito | Barry Zito | Trevor Cahill | Santiago Casilla | 203 | 221 | -18 |
| 2012-05-29 | @ SFN | 50 | L 1-3 | 22-28 | 3 | 41,371 | Joe Saunders | Ryan Vogelsong | Clay Hensley | Bryan Shaw | Santiago Casilla | 204 | 224 | -20 |
| 2012-05-30 | @ SFN | 51 | W 4-1 | 23-28 | 3 | 41,328 | Ian Kennedy | Tim Lincecum | Ian Kennedy | Tim Lincecum | David Hernandez | 208 | 225 | -17 |
| 2012-06-01 | @ SDN | 52 | L 1-7 | 23-29 | 3 | 27,054 | Wade Miley | Clayton Richard | Andrew Cashner | Wade Miley | | 209 | 232 | -23 |
| 2012-06-02 | @ SDN | 53 | W 4-2 | 24-29 | 3 | 36,559 | Daniel Hudson | Edinson Volquez | Daniel Hudson | Joe Thatcher | J.J. Putz | 213 | 234 | -21 |
| 2012-06-03 | @ SDN | 54 | W 6-0 | 25-29 | 3 | 32,228 | Trevor Cahill | Eric Stults | Trevor Cahill | Eric Stults | | 219 | 234 | -15 |
| 2012-06-04 | vs COL | 55 | L 0-4 | 25-30 | 3 | 22,881 | Joe Saunders | Christian Friedrich | Christian Friedrich | Joe Saunders | | 219 | 238 | -19 |
| 2012-06-05 | vs COL | 56 | W 10-0 | 26-30 | 3 | 22,322 | Ian Kennedy | Jeremy Guthrie | Ian Kennedy | Jeremy Guthrie | | 229 | 238 | -9 |
| 2012-06-06 | vs COL | 57 | W 6-1 | 27-30 | 3 | 23,069 | Wade Miley | Josh Outman | Wade Miley | Josh Outman | | 235 | 239 | -4 |
| 2012-06-08 | vs OAK | 58 | W 9-8 | 28-30 | 3 | 25,787 | Daniel Hudson | Tom Milone | J.J. Putz | Brian Fuentes | | 244 | 247 | -3 |
| 2012-06-09 | vs OAK | 59 | W 8-3 | 29-30 | 3 | 28,061 | Trevor Cahill | Jarrod Parker | Trevor Cahill | Jarrod Parker | | 252 | 250 | 2 |
| 2012-06-10 | vs OAK | 60 | W 4-3 | 30-30 | 3 | 28,112 | Joe Saunders | Travis Blackley | Joe Saunders | Travis Blackley | J.J. Putz | 256 | 253 | 3 |
| 2012-06-12 | @ TEX | 61 | L 1-9 | 30-31 | 3 | 39,140 | Ian Kennedy | Colby Lewis | Colby Lewis | Ian Kennedy | | 257 | 262 | -5 |
| 2012-06-13 | @ TEX | 62 | L 0-1 | 30-32 | 3 | 45,866 | Wade Miley | Matt Harrison | Mike Adams | Wade Miley | Joe Nathan | 257 | 263 | -6 |
| 2012-06-14 | @ TEX | 63 | L 11-3 | 30-33 | 3 | 40,855 | Daniel Hudson | Scott Feldman | Daniel Hudson | Scott Feldman | | 268 | 266 | 2 |
| 2012-06-15 | @ ANA | 64 | W 5-0 | 31-33 | 3 | 37,096 | Trevor Cahill | Dan Haren | Trevor Cahill | Dan Haren | | 273 | 266 | 7 |
| 2012-06-16 | @ ANA | 65 | L 0-2 | 31-34 | 3 | 42,483 | Joe Saunders | Ervin Santana | Ervin Santana | Joe Saunders | | 273 | 268 | 5 |
| 2012-06-17 | @ ANA | 66 | L 0-2 | 31-35 | 3 | 42,222 | Ian Kennedy | Garrett Richards | Garrett Richards | Ian Kennedy | Ernesto Frieri | 273 | 270 | 3 |
| 2012-06-18 | vs SEA | 67 | W 7-1 | 32-35 | 3 | 24,284 | Wade Miley | Hector Noesi | Wade Miley | Hector Noesi | | 280 | 271 | 9 |
| 2012-06-19 | vs SEA | 68 | W 9-12 | 33-35 | 3 | 21,568 | Daniel Hudson | Erasmo Ramirez | Charlie Furbush | J.J. Putz | Tom Wilhelmsen | 289 | 283 | 6 |
| 2012-06-20 | vs SEA | 69 | W 14-10 | 34-35 | 3 | 29,630 | Trevor Cahill | Jason Vargas | Trevor Cahill | Jason Vargas | | 303 | 293 | 10 |
| 2012-06-22 | vs CHN | 70 | W 6-1 | 35-35 | 3 | 34,654 | Josh Collmenter | Jeff Samardzija | Brad Ziegler | Jeff Samardzija | David Hernandez | 309 | 294 | 15 |
| 2012-06-23 | vs CHN | 71 | L 10-5 | 35-36 | 3 | 38,542 | Ian Kennedy | Paul Maholm | Craig Breslow | Paul Maholm | | 319 | 299 | 20 |
| 2012-06-24 | vs CHN | 72 | W 5-1 | 36-36 | 3 | 33,448 | Wade Miley | Matt Garza | Wade Miley | Matt Garza | | 324 | 300 | 24 |
| 2012-06-26 | @ ATL | 73 | L 1-8 | 36-37 | 3 | 23,513 | Daniel Hudson | Tim Hudson | Tim Hudson | Daniel Hudson | | 325 | 308 | 17 |
| 2012-06-27 | @ ATL | 74 | L 4-6 | 36-38 | 3 | 20,039 | Trevor Cahill | Tommy Hanson | Tommy Hanson | Trevor Cahill | Craig Kimbrel | 329 | 314 | 15 |
| 2012-06-28 | @ ATL | 75 | W 3-2 | 37-38 | 3 | 21,913 | Trevor Bauer | Jair Jurrjens | David Hernandez | Craig Kimbrel | J.J. Putz | 332 | 316 | 16 |
| 2012-06-29 | @ MIL | 76 | W 9-3 | 38-38 | 3 | 38,030 | Ian Kennedy | Randy Wolf | Ian Kennedy | Randy Wolf | | 341 | 319 | 22 |
| 2012-06-30 | @ MIL | 77 | W 2-10 | 39-38 | 3 | 41,647 | Wade Miley | Michael Fiers | Michael Fiers | Wade Miley | | 343 | 329 | 14 |
| 2012-07-01 | @ MIL | 78 | L 1-2 | 39-39 | 3 | 38,605 | Josh Collmenter | Yovani Gallardo | John Axford | Patrick Corbin | | 344 | 331 | 13 |
| 2012-07-02 | vs SDN | 79 | L 2-6 | 39-40 | 3 | 19,633 | Trevor Cahill | Clayton Richard | Clayton Richard | Trevor Cahill | Joe Thatcher | 346 | 337 | 9 |
| 2012-07-03 | vs SDN | 80 | L 5-9 | 39-41 | 3 | 21,329 | Trevor Bauer | Andrew Cashner | Ross Ohlendorf | Trevor Bauer | | 351 | 346 | 5 |
| 2012-07-04 | vs SDN | 81 | L 6-8 | 39-42 | 3 | 48,819 | Ian Kennedy | Jason Marquis | Luke Gregerson | David Hernandez | Huston Street | 357 | 354 | 3 |
| 2012-07-05 | vs LAN | 82 | L 1-4 | 39-43 | 3 | 23,002 | Wade Miley | Nathan Eovaldi | Nathan Eovaldi | Wade Miley | Kenley Jansen | 358 | 358 | 0 |
| 2012-07-06 | vs LAN | 83 | W 5-3 | 40-43 | 3 | 24,891 | Josh Collmenter | Clayton Kershaw | Josh Collmenter | Clayton Kershaw | J.J. Putz | 363 | 361 | 2 |
| 2012-07-07 | vs LAN | 84 | W 5-3 | 41-43 | 3 | 36,903 | Trevor Cahill | Chad Billingsley | Trevor Cahill | Chad Billingsley | J.J. Putz | 368 | 364 | 4 |
| 2012-07-08 | vs LAN | 85 | W 7-1 | 42-43 | 3 | 30,523 | Trevor Bauer | Chris Capuano | Trevor Bauer | Chris Capuano | Patrick Corbin | 375 | 365 | 10 |
| 2012-07-13 | @ CHN | 86 | L 1-8 | 42-44 | 3 | 36,878 | Ian Kennedy | Paul Maholm | Paul Maholm | Ian Kennedy | | 376 | 373 | 3 |
| 2012-07-14 | @ CHN | 87 | L 1-4 | 42-45 | 3 | 38,068 | Joe Saunders | Ryan Dempster | Ryan Dempster | Joe Saunders | Carlos Marmol | 377 | 377 | 0 |
| 2012-07-15 | @ CHN | 88 | L 1-3 | 42-46 | 3 | 36,659 | Trevor Cahill | Matt Garza | Matt Garza | Trevor Cahill | Carlos Marmol | 378 | 380 | -2 |
| 2012-07-16 | @ CIN | 89 | W 5-3 | 43-46 | 3 | 27,735 | Wade Miley | Bronson Arroyo | Wade Miley | Bronson Arroyo | J.J. Putz | 383 | 383 | 0 |
| 2012-07-17 | @ CIN | 90 | L 0-4 | 43-47 | 3 | 19,142 | Trevor Bauer | Johnny Cueto | Johnny Cueto | Trevor Bauer | Aroldis Chapman | 383 | 387 | -4 |
| 2012-07-18 | @ CIN | 91 | W 7-1 | 44-47 | 3 | 26,077 | Ian Kennedy | Mat Latos | Ian Kennedy | Mat Latos | | 390 | 388 | 2 |
| 2012-07-19 | @ CIN | 92 | L 6-7 | 44-48 | 3 | 21,620 | Joe Saunders | Mike Leake | Alfredo Simon | Bryan Shaw | Aroldis Chapman | 396 | 395 | 1 |
| 2012-07-20 | vs HOU | 93 | L 13-8 | 44-49 | 3 | 23,567 | Trevor Cahill | Bud Norris | Trevor Cahill | Bud Norris | | 409 | 403 | 6 |
| 2012-07-21 | vs HOU | 94 | L 12-3 | 44-50 | 3 | 35,665 | Wade Miley | Dallas Keuchel | Wade Miley | Dallas Keuchel | | 421 | 406 | 15 |
| 2012-07-22 | vs HOU | 95 | W 8-2 | 45-50 | 3 | 20,951 | Josh Collmenter | Jordan Lyles | Josh Collmenter | Jordan Lyles | | 429 | 408 | 21 |
| 2012-07-23 | vs COL | 96 | W 6-3 | 46-50 | 3 | 20,056 | Ian Kennedy | Jonathan Sanchez | Ian Kennedy | Jonathan Sanchez | J.J. Putz | 435 | 411 | 24 |
| 2012-07-24 | vs COL | 97 | W 6-2 | 47-50 | 3 | 20,432 | Joe Saunders | Edwar Cabrera | Joe Saunders | Edwar Cabrera | | 441 | 413 | 28 |
| 2012-07-25 | vs COL | 98 | L 2-4 | 47-51 | 3 | 23,385 | Trevor Cahill | Jeff Francis | Jeff Francis | Trevor Cahill | Rafael Betancourt | 443 | 417 | 26 |
| 2012-07-26 | vs NYN | 99 | L 1-3 | 47-52 | 3 | 22,010 | Wade Miley | Matt Harvey | Matt Harvey | Wade Miley | Bobby Parnell | 444 | 420 | 24 |
| 2012-07-27 | vs NYN | 100 | L 11-5 | 47-53 | 3 | 23,150 | Josh Collmenter | Jonathon Niese | Josh Collmenter | Jonathon Niese | | 455 | 425 | 30 |
| 2012-07-28 | vs NYN | 101 | W 6-3 | 48-53 | 3 | 33,759 | Ian Kennedy | Chris Young | Ian Kennedy | Chris Young | J.J. Putz | 461 | 428 | 33 |
| 2012-07-29 | vs NYN | 102 | L 1-5 | 48-54 | 3 | 32,134 | Joe Saunders | R.A. Dickey | R.A. Dickey | Joe Saunders | | 462 | 433 | 29 |
| 2012-07-30 | @ LAN | 103 | W 7-2 | 49-54 | 3 | 33,180 | Trevor Cahill | Aaron Harang | Trevor Cahill | Aaron Harang | | 469 | 435 | 34 |
| 2012-07-31 | @ LAN | 104 | W 8-2 | 50-54 | 3 | 52,832 | Wade Miley | Chris Capuano | Wade Miley | Chris Capuano | | 477 | 437 | 40 |
| 2012-08-01 | @ LAN | 105 | W 4-0 | 51-54 | 3 | 36,596 | Patrick Corbin | Stephen Fife | Patrick Corbin | Stephen Fife | | 481 | 437 | 44 |
| 2012-08-03 | @ PHI | 106 | W 4-2 | 52-54 | 3 | 43,766 | Ian Kennedy | Kyle Kendrick | Ian Kennedy | Kyle Kendrick | J.J. Putz | 485 | 439 | 46 |
| 2012-08-04 | @ PHI | 107 | L 0-3 | 52-55 | 3 | 43,762 | Joe Saunders | Roy Halladay | Roy Halladay | Joe Saunders | Jonathan Papelbon | 485 | 442 | 43 |
| 2012-08-05 | @ PHI | 108 | L 4-5 | 52-56 | 3 | 43,741 | Trevor Cahill | Cliff Lee | Jonathan Papelbon | Josh Collmenter | | 489 | 447 | 42 |
| 2012-08-06 | @ PIT | 109 | L 0-4 | 52-57 | 3 | 24,213 | Wade Miley | Erik Bedard | Erik Bedard | Wade Miley | | 489 | 451 | 38 |
| 2012-08-07 | @ PIT | 110 | L 10-4 | 52-58 | 3 | 22,655 | Patrick Corbin | Jeff Karstens | Brad Ziegler | Jason Grilli | | 499 | 455 | 44 |
| 2012-08-08 | @ PIT | 111 | L 6-7 | 52-59 | 3 | 25,175 | Ian Kennedy | Kevin Correia | Kevin Correia | Ian Kennedy | Joel Hanrahan | 505 | 462 | 43 |
| 2012-08-09 | @ PIT | 112 | W 6-3 | 53-59 | 3 | 20,558 | Joe Saunders | Wandy Rodriguez | Joe Saunders | Wandy Rodriguez | J.J. Putz | 511 | 465 | 46 |
| 2012-08-10 | vs WAS | 113 | L 1-9 | 53-60 | 3 | 29,362 | Trevor Cahill | Stephen Strasburg | Stephen Strasburg | Trevor Cahill | | 512 | 474 | 38 |
| 2012-08-11 | vs WAS | 114 | L 5-6 | 53-61 | 3 | 34,030 | Wade Miley | Edwin Jackson | Edwin Jackson | Wade Miley | Tyler Clippard | 517 | 480 | 37 |
| 2012-08-12 | vs WAS | 115 | W 7-4 | 54-61 | 3 | 27,345 | Patrick Corbin | Ross Detwiler | Patrick Corbin | Ross Detwiler | J.J. Putz | 524 | 484 | 40 |
| 2012-08-14 | @ SLN | 116 | L 2-8 | 54-62 | 3 | 34,587 | Ian Kennedy | Joe Kelly | Joe Kelly | Ian Kennedy | | 526 | 492 | 34 |
| 2012-08-15 | @ SLN | 117 | L 2-5 | 54-63 | 3 | 33,572 | Joe Saunders | Adam Wainwright | Adam Wainwright | Joe Saunders | Jason Motte | 528 | 497 | 31 |
| 2012-08-16 | @ SLN | 118 | W 2-1 | 55-63 | 3 | 36,758 | Trevor Cahill | Kyle Lohse | David Hernandez | Jason Motte | J.J. Putz | 530 | 498 | 32 |
| 2012-08-17 | @ HOU | 119 | W 3-1 | 56-63 | 3 | 19,223 | Wade Miley | Dallas Keuchel | Wade Miley | Dallas Keuchel | J.J. Putz | 533 | 499 | 34 |
| 2012-08-18 | @ HOU | 120 | L 12-4 | 56-64 | 3 | 20,838 | Patrick Corbin | Jordan Lyles | Patrick Corbin | Jordan Lyles | | 545 | 503 | 42 |
| 2012-08-19 | @ HOU | 121 | W 8-1 | 57-64 | 3 | 14,923 | Ian Kennedy | Armando Galarraga | Ian Kennedy | Armando Galarraga | | 553 | 504 | 49 |
| 2012-08-20 | vs MIA | 122 | W 3-12 | 58-64 | 3 | 17,707 | Joe Saunders | Mark Buehrle | Mark Buehrle | Joe Saunders | | 556 | 516 | 40 |
| 2012-08-21 | vs MIA | 123 | L 5-6 | 58-65 | 3 | 17,434 | Trevor Cahill | Ricky Nolasco | Chad Gaudin | Sam Demel | Steve Cishek | 561 | 522 | 39 |
| 2012-08-22 | vs MIA | 124 | W 3-2 | 59-65 | 4 | 17,239 | Tyler Skaggs | Jacob Turner | Tyler Skaggs | Jacob Turner | J.J. Putz | 564 | 524 | 40 |
| 2012-08-22 | vs MIA | 125 | W 3-0 | 59-65 | 4 | 20,027 | Wade Miley | Wade LeBlanc | Wade Miley | Wade LeBlanc | J.J. Putz | 567 | 524 | 43 |
| 2012-08-24 | vs SDN | 126 | L 0-5 | 60-66 | 3 | 32,726 | Patrick Corbin | Eric Stults | Eric Stults | Patrick Corbin | | 567 | 529 | 38 |
| 2012-08-25 | vs SDN | 127 | L 3-9 | 60-67 | 3 | 27,619 | Ian Kennedy | Clayton Richard | Clayton Richard | Ian Kennedy | | 570 | 538 | 32 |
| 2012-08-26 | vs SDN | 128 | L 4-5 | 60-68 | 4 | 28,172 | Trevor Cahill | Edinson Volquez | Edinson Volquez | Trevor Cahill | Luke Gregerson | 574 | 543 | 31 |
| 2012-08-27 | vs CIN | 129 | L 2-3 | 60-69 | 4 | 17,966 | Tyler Skaggs | Bronson Arroyo | Bronson Arroyo | Tyler Skaggs | Aroldis Chapman | 576 | 546 | 30 |
| 2012-08-28 | vs CIN | 130 | L 2-5 | 60-70 | 4 | 20,550 | Wade Miley | Johnny Cueto | Johnny Cueto | Wade Miley | Aroldis Chapman | 578 | 551 | 27 |
| 2012-08-29 | vs CIN | 131 | L 2-6 | 60-71 | 4 | 18,451 | Patrick Corbin | Mat Latos | Mat Latos | Patrick Corbin | | 580 | 557 | 23 |
| 2012-08-30 | @ LAN | 132 | W 2-0 | 61-71 | 4 | 54,621 | Ian Kennedy | Clayton Kershaw | Ian Kennedy | Clayton Kershaw | J.J. Putz | 582 | 557 | 25 |
| 2012-08-31 | @ LAN | 133 | W 4-3 | 62-71 | 4 | 37,622 | Trevor Cahill | Aaron Harang | Brad Bergesen | Matt Guerrier | J.J. Putz | 586 | 560 | 26 |
| 2012-09-01 | @ LAN | 134 | L 1-2 | 62-72 | 4 | 35,992 | Tyler Skaggs | Josh Beckett | Josh Beckett | Matt Albers | Brandon League | 587 | 562 | 25 |
| 2012-09-02 | @ LAN | 135 | L 4-5 | 62-73 | 4 | 31,607 | Wade Miley | Chris Capuano | Ronald Belisario | J.J. Putz | | 591 | 567 | 24 |
| 2012-09-03 | @ SFN | 136 | L 8-9 | 62-74 | 4 | 42,045 | Patrick Corbin | Barry Zito | Sergio Romo | Bryan Shaw | | 599 | 576 | 23 |
| 2012-09-04 | @ SFN | 137 | W 8-6 | 63-74 | 4 | 41,038 | Ian Kennedy | Ryan Vogelsong | Josh Collmenter | George Kontos | | 607 | 582 | 25 |
| 2012-09-05 | @ SFN | 138 | W 6-2 | 64-74 | 4 | 41,035 | Trevor Cahill | Madison Bumgarner | Trevor Cahill | Madison Bumgarner | | 613 | 584 | 29 |
| 2012-09-07 | @ SDN | 139 | L 5-6 | 64-75 | 4 | 25,403 | Tyler Skaggs | Andrew Cashner | Brad Brach | David Hernandez | Luke Gregerson | 618 | 590 | 28 |
| 2012-09-08 | @ SDN | 140 | W 8-5 | 65-75 | 4 | 25,514 | Wade Miley | Casey Kelly | Wade Miley | Casey Kelly | J.J. Putz | 626 | 595 | 31 |
| 2012-09-09 | @ SDN | 141 | L 2-8 | 65-76 | 4 | 21,037 | Patrick Corbin | Andrew Werner | Andrew Werner | Patrick Corbin | | 628 | 603 | 25 |
| 2012-09-11 | vs LAN | 142 | W 1-0 | 66-76 | 4 | 23,966 | Ian Kennedy | Clayton Kershaw | Ian Kennedy | Clayton Kershaw | David Hernandez | 629 | 603 | 26 |
| 2012-09-12 | vs LAN | 143 | W 3-2 | 67-76 | 4 | 25,048 | Trevor Cahill | Aaron Harang | Trevor Cahill | Aaron Harang | David Hernandez | 632 | 605 | 27 |
| 2012-09-14 | vs SFN | 144 | L 2-6 | 67-77 | 4 | 31,856 | Tyler Skaggs | Matt Cain | Matt Cain | Tyler Skaggs | | 634 | 611 | 23 |
| 2012-09-15 | vs SFN | 145 | L 2-3 | 67-78 | 4 | 39,169 | Wade Miley | Barry Zito | Barry Zito | Wade Miley | Sergio Romo | 636 | 614 | 22 |
| 2012-09-16 | vs SFN | 146 | L 10-2 | 67-79 | 4 | 29,051 | Patrick Corbin | Ryan Vogelsong | Patrick Corbin | Ryan Vogelsong | | 646 | 616 | 30 |
| 2012-09-18 | vs SDN | 147 | W 3-2 | 68-79 | 4 | 20,811 | Ian Kennedy | Eric Stults | Ian Kennedy | Eric Stults | J.J. Putz | 649 | 618 | 31 |
| 2012-09-19 | vs SDN | 148 | W 6-2 | 69-79 | 5 | 21,013 | Trevor Cahill | Edinson Volquez | Trevor Cahill | Edinson Volquez | | 655 | 620 | 35 |
| 2012-09-20 | vs SDN | 149 | L 5-6 | 69-80 | 4 | 17,821 | Tyler Skaggs | Clayton Richard | Clayton Richard | Tyler Skaggs | Anthony Bass | 660 | 626 | 34 |
| 2012-09-21 | @ COL | 150 | L 15-5 | 69-81 | 4 | 42,359 | Wade Miley | Drew Pomeranz | Wade Miley | Alex White | | 675 | 631 | 44 |
| 2012-09-22 | @ COL | 151 | W 8-7 | 70-81 | 4 | 33,689 | Patrick Corbin | Jhoulis Chacin | Brad Bergesen | Carlos Torres | J.J. Putz | 683 | 638 | 45 |
| 2012-09-23 | @ COL | 152 | L 10-7 | 70-82 | 4 | 32,448 | Ian Kennedy | Jeff Francis | Matt Albers | Matt Belisle | J.J. Putz | 693 | 645 | 48 |
| 2012-09-24 | @ COL | 153 | L 2-4 | 70-83 | 4 | 22,277 | Trevor Cahill | Tyler Chatwood | Tyler Chatwood | Trevor Cahill | Rafael Betancourt | 695 | 649 | 46 |
| 2012-09-25 | @ SFN | 154 | W 7-2 | 71-83 | 4 | 41,153 | Josh Collmenter | Tim Lincecum | Josh Collmenter | Tim Lincecum | | 702 | 651 | 51 |
| 2012-09-26 | @ SFN | 155 | L 0-6 | 71-84 | 4 | 41,516 | Wade Miley | Matt Cain | Matt Cain | Wade Miley | | 702 | 657 | 45 |
| 2012-09-27 | @ SFN | 156 | L 3-7 | 71-85 | 4 | 41,128 | Patrick Corbin | Barry Zito | Barry Zito | Patrick Corbin | | 705 | 664 | 41 |
| 2012-09-28 | vs CHN | 157 | W 8-3 | 72-85 | 4 | 28,463 | Ian Kennedy | Travis Wood | Ian Kennedy | Travis Wood | | 713 | 667 | 46 |
| 2012-09-29 | vs CHN | 158 | W 8-2 | 73-85 | 4 | 29,084 | Trevor Cahill | Justin Germano | Trevor Cahill | Justin Germano | | 721 | 669 | 52 |
| 2012-09-30 | vs CHN | 159 | L 2-7 | 73-86 | 4 | 35,535 | Josh Collmenter | Chris Rusin | Chris Rusin | Bryan Shaw | | 723 | 676 | 47 |
| 2012-10-01 | vs COL | 160 | L 5-7 | 73-87 | 4 | 24,123 | Wade Miley | Drew Pomeranz | Josh Outman | Brad Bergesen | Josh Roenicke | 728 | 683 | 45 |
| 2012-10-02 | vs COL | 161 | W 5-3 | 74-87 | 4 | 22,466 | Patrick Corbin | Jhoulis Chacin | Brad Ziegler | Rafael Betancourt | | 733 | 686 | 47 |
| 2012-10-03 | vs COL | 162 | L 1-2 | 74-88 | 4 | 24,344 | Ian Kennedy | Jeff Francis | Jeff Francis | Ian Kennedy | Matt Belisle | 734 | 688 | 46 |