| Josh Beckett | 20 | 20 | 10 | 120.3 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 468 | 519 | 25 | 3 | 5 | 2 | 15 | 2 | 0 | 60 | 165 | 223 | 0.74 | 7 | 1869 | 1204 | 665 | 345 | 300 | 171 | 20 | 69 | 2 |
| Ronald Belisario | 67 | 0 | 0 | 0 | 67 | 69.7 | 7.7 | 22 | 2 | 33 | 10 | 66 | 21 | 31.8 | 248 | 282 | 12 | 1 | 4 | 4 | 4 | 0 | 0 | 28 | 117 | 64 | 1.83 | 6 | 1053 | 662 | 391 | 165 | 205 | 111 | 14 | 54 | 5 |
| Chad Billingsley | 25 | 25 | 14 | 149.7 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 575 | 633 | 37 | 9 | 5 | 2 | 10 | 3 | 0 | 80 | 216 | 243 | 0.89 | 8 | 2374 | 1485 | 889 | 414 | 417 | 198 | 34 | 91 | 7 |
| Joe Blanton | 20 | 19 | 10 | 126.7 | 1 | 0.7 | 10.0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 508 | 536 | 26 | 4 | 3 | 2 | 4 | 3 | 0 | 33 | 185 | 224 | 0.83 | 5 | 1896 | 1266 | 630 | 268 | 395 | 194 | 44 | 64 | 2 |
| Chris Capuano | 32 | 32 | 17 | 190.3 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 717 | 790 | 33 | 4 | 2 | 4 | 6 | 2 | 4 | 178 | 251 | 334 | 0.75 | 15 | 2874 | 1873 | 1001 | 447 | 519 | 322 | 45 | 107 | 7 |
| Randy Choate | 35 | 0 | 0 | 0 | 35 | 13.3 | 7.0 | 5 | 1 | 28 | 7 | 66 | 15 | 22.7 | 51 | 63 | 1 | 0 | 2 | 3 | 2 | 0 | 0 | 14 | 28 | 13 | 2.15 | 0 | 235 | 134 | 101 | 29 | 38 | 25 | 2 | 9 | 1 |
| Todd Coffey | 23 | 0 | 0 | 0 | 23 | 19.3 | 7.3 | 2 | 0 | 6 | 2 | 15 | 5 | 33.3 | 71 | 83 | 3 | 2 | 2 | 1 | 1 | 1 | 0 | 9 | 33 | 21 | 1.57 | 2 | 328 | 196 | 132 | 56 | 54 | 32 | 3 | 15 | 0 |
| Rubby De La Rosa | 1 | 0 | 0 | 0 | 1 | 0.7 | 7.0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 2 | 4 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2 | 0.00 | 0 | 20 | 10 | 10 | 5 | 2 | 1 | 0 | 0 | 1 |
| Scott Elbert | 43 | 0 | 0 | 0 | 43 | 32.7 | 6.8 | 9 | 0 | 48 | 10 | 102 | 19 | 18.6 | 117 | 133 | 3 | 0 | 1 | 1 | 3 | 1 | 0 | 18 | 33 | 57 | 0.58 | 3 | 560 | 336 | 224 | 80 | 99 | 67 | 6 | 23 | 0 |
| John Ely | 2 | 0 | 0 | 0 | 2 | 2.7 | 11.0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 13 | 19 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 7 | 4 | 1.75 | 0 | 75 | 40 | 35 | 16 | 8 | 5 | 1 | 2 | 0 |
| Nathan Eovaldi | 10 | 10 | 5 | 56.3 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 218 | 241 | 13 | 1 | 0 | 2 | 2 | 1 | 3 | 66 | 91 | 96 | 0.95 | 9 | 955 | 605 | 350 | 186 | 159 | 73 | 8 | 26 | 6 |
| Stephen Fife | 5 | 5 | 2 | 26.7 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 98 | 115 | 3 | 0 | 2 | 0 | 1 | 0 | 0 | 25 | 37 | 44 | 0.84 | 1 | 423 | 262 | 161 | 72 | 73 | 36 | 6 | 14 | 7 |
| Javy Guerra | 44 | 0 | 0 | 0 | 44 | 43 | 7.6 | 5 | 4 | 21 | 8 | 45 | 17 | 37.8 | 159 | 189 | 6 | 1 | 1 | 5 | 1 | 0 | 0 | 25 | 66 | 64 | 1.03 | 5 | 718 | 426 | 292 | 124 | 111 | 61 | 6 | 29 | 4 |
| Matt Guerrier | 16 | 0 | 0 | 0 | 16 | 14 | 7.6 | 3 | 1 | 3 | 0 | 6 | 0 | 0.0 | 46 | 56 | 1 | 0 | 1 | 1 | 3 | 0 | 0 | 17 | 15 | 24 | 0.63 | 1 | 226 | 138 | 88 | 40 | 31 | 28 | 1 | 8 | 1 |
| Aaron Harang | 31 | 31 | 16 | 179.7 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 678 | 786 | 42 | 4 | 4 | 10 | 8 | 2 | 1 | 119 | 232 | 336 | 0.69 | 13 | 3093 | 1871 | 1222 | 557 | 505 | 243 | 32 | 97 | 12 |
| Kenley Jansen | 64 | 0 | 0 | 0 | 64 | 64 | 8.5 | 7 | 3 | 13 | 3 | 27 | 4 | 14.8 | 222 | 247 | 6 | 2 | 3 | 1 | 5 | 0 | 0 | 22 | 41 | 85 | 0.48 | 1 | 1031 | 688 | 343 | 194 | 221 | 148 | 18 | 79 | 5 |
| Clayton Kershaw | 32 | 32 | 24 | 221.3 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 787 | 876 | 38 | 3 | 5 | 5 | 8 | 12 | 12 | 173 | 288 | 298 | 0.97 | 17 | 3344 | 2140 | 1204 | 574 | 604 | 375 | 61 | 161 | 6 |
| Brandon League | 46 | 0 | 0 | 0 | 46 | 44.7 | 8.3 | 5 | 6 | 13 | 3 | 27 | 7 | 25.9 | 171 | 193 | 5 | 1 | 0 | 3 | 4 | 1 | 0 | 10 | 71 | 76 | 0.93 | 5 | 682 | 418 | 264 | 100 | 113 | 58 | 4 | 23 | 3 |
| Ted Lilly | 8 | 8 | 6 | 48.7 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 177 | 202 | 4 | 2 | 2 | 1 | 7 | 1 | 1 | 48 | 67 | 83 | 0.81 | 3 | 703 | 460 | 243 | 110 | 137 | 63 | 10 | 21 | 7 |
| Josh Lindblom | 48 | 0 | 0 | 0 | 48 | 47.7 | 7.5 | 15 | 2 | 21 | 6 | 39 | 11 | 28.2 | 174 | 197 | 6 | 0 | 3 | 0 | 3 | 3 | 1 | 41 | 53 | 80 | 0.66 | 5 | 802 | 504 | 298 | 168 | 117 | 86 | 8 | 35 | 1 |
| Mike MacDougal | 7 | 0 | 0 | 0 | 7 | 5.7 | 6.9 | 2 | 0 | 1 | 0 | 3 | 0 | 0.0 | 26 | 32 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 7 | 15 | 0.47 | 0 | 122 | 70 | 52 | 17 | 27 | 4 | 3 | 1 | 2 |
| Steve Rodriguez | 11 | 0 | 0 | 0 | 11 | 6.7 | 6.1 | 0 | 0 | 12 | 1 | 27 | 1 | 3.7 | 22 | 26 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 7 | 9 | 0.78 | 0 | 105 | 62 | 43 | 22 | 10 | 14 | 1 | 5 | 0 |
| Shawn Tolleson | 39 | 0 | 0 | 0 | 39 | 37.3 | 6.8 | 2 | 0 | 35 | 4 | 75 | 11 | 14.7 | 135 | 159 | 9 | 0 | 1 | 1 | 1 | 0 | 1 | 25 | 42 | 57 | 0.74 | 6 | 650 | 396 | 254 | 126 | 91 | 80 | 10 | 29 | 2 |
| Josh Wall | 7 | 0 | 0 | 0 | 7 | 5.7 | 9.0 | 0 | 0 | 6 | 0 | 12 | 0 | 0.0 | 19 | 21 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 4 | 6 | 9 | 0.67 | 1 | 78 | 50 | 28 | 13 | 11 | 11 | 0 | 4 | 0 |
| Jamey Wright | 64 | 0 | 0 | 0 | 64 | 66.3 | 7.0 | 5 | 0 | 44 | 7 | 96 | 14 | 14.6 | 263 | 303 | 9 | 0 | 4 | 7 | 10 | 1 | 4 | 60 | 149 | 67 | 2.22 | 5 | 1126 | 670 | 456 | 163 | 189 | 102 | 8 | 44 | 10 |