| East | W | L | Pct | GB |
| NY Yankees | 97 | 65 | .599 | -- |
| Tampa Bay | 91 | 71 | .562 | 6.0 |
| Boston | 90 | 72 | .556 | 7.0 |
| Toronto | 81 | 81 | .500 | 16.0 |
| Baltimore | 69 | 93 | .426 | 28.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2011-04-01 | Jon Lester | L | 27 | L 5-9 | @ TEX | 1 | 124 | - | 5.1 | 6 | 5 | 5 | 3 | 1 | 0 | 88 | 39 | 49 | 56% | 0-0 | 9.00 | 1.40 |
| 2011-04-02 | John Lackey | R | 32 | L 5-12 | @ TEX | 1 | 267 | L | 3.2 | 10 | 9 | 9 | 2 | 2 | 3 | 90 | 38 | 52 | 58% | 0-1 | 20.25 | 3.00 |
| 2011-04-03 | Clay Buchholz | R | 27 | L 1-5 | @ TEX | 1 | 63 | L | 6.1 | 5 | 4 | 4 | 4 | 2 | 3 | 89 | 32 | 57 | 64% | 0-1 | 6.00 | 1.17 |
| 2011-04-05 | Josh Beckett | R | 31 | L 1-3 | @ CLE | 1 | 247 | L | 5.0 | 5 | 3 | 3 | 0 | 4 | 4 | 112 | 45 | 67 | 60% | 0-1 | 5.40 | 1.80 |
| 2011-04-06 | Daisuke Matsuzaka | R | 31 | L 4-8 | @ CLE | 1 | 99 | L | 5.0 | 6 | 3 | 3 | 1 | 3 | 2 | 96 | 42 | 54 | 56% | 0-1 | 5.40 | 1.80 |
| 2011-04-07 | Jon Lester | L | 27 | L 0-1 | @ CLE | 2 | 125 | - | 7.0 | 3 | 0 | 0 | 0 | 3 | 9 | 109 | 43 | 66 | 61% | 0-0 | 3.75 | 1.08 |
| 2011-04-08 | John Lackey | R | 32 | L 9-6 | vs NYA | 2 | 268 | W | 5.0 | 7 | 6 | 6 | 1 | 2 | 2 | 91 | 40 | 51 | 56% | 1-1 | 15.00 | 2.33 |
| 2011-04-09 | Clay Buchholz | R | 27 | W 4-9 | vs NYA | 2 | 64 | L | 3.2 | 8 | 5 | 4 | 1 | 3 | 2 | 92 | 37 | 55 | 60% | 0-2 | 7.20 | 1.80 |
| 2011-04-10 | Josh Beckett | R | 31 | L 4-0 | vs NYA | 2 | 248 | W | 8.0 | 2 | 0 | 0 | 0 | 1 | 10 | 100 | 35 | 65 | 65% | 1-1 | 2.08 | 0.92 |
| 2011-04-11 | Daisuke Matsuzaka | R | 31 | W 5-16 | vs TBA | 2 | 100 | L | 2.0 | 8 | 7 | 7 | 2 | 2 | 2 | 46 | 15 | 31 | 67% | 0-2 | 12.86 | 2.71 |
| 2011-04-12 | Jon Lester | L | 27 | W 2-3 | vs TBA | 3 | 126 | L | 7.0 | 7 | 3 | 3 | 0 | 2 | 8 | 109 | 42 | 67 | 61% | 0-1 | 3.79 | 1.16 |
| 2011-04-15 | Clay Buchholz | R | 27 | W 6-7 | vs TOR | 3 | 65 | - | 5.0 | 3 | 3 | 3 | 0 | 5 | 3 | 93 | 48 | 45 | 48% | 0-2 | 6.60 | 1.73 |
| 2011-04-16 | Josh Beckett | R | 31 | L 4-1 | vs TOR | 3 | 249 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 9 | 101 | 37 | 64 | 63% | 2-1 | 1.80 | 0.85 |
| 2011-04-17 | Jon Lester | L | 27 | L 8-1 | vs TOR | 4 | 127 | W | 6.0 | 6 | 1 | 1 | 0 | 3 | 5 | 109 | 44 | 65 | 60% | 1-1 | 3.24 | 1.24 |
| 2011-04-18 | Daisuke Matsuzaka | R | 31 | L 9-1 | vs TOR | 3 | 101 | W | 7.0 | 1 | 0 | 0 | 0 | 1 | 3 | 88 | 31 | 57 | 65% | 1-2 | 6.43 | 1.50 |
| 2011-04-19 | John Lackey | R | 32 | L 0-5 | @ OAK | 3 | 269 | L | 6.0 | 4 | 1 | 1 | 0 | 1 | 3 | 100 | 37 | 63 | 63% | 1-2 | 9.60 | 1.73 |
| 2011-04-20 | Clay Buchholz | R | 27 | W 5-3 | @ OAK | 4 | 66 | W | 5.1 | 6 | 1 | 1 | 1 | 4 | 2 | 102 | 43 | 59 | 58% | 1-2 | 5.40 | 1.80 |
| 2011-04-21 | Josh Beckett | R | 31 | W 4-2 | @ ANA | 4 | 250 | - | 8.0 | 3 | 2 | 2 | 1 | 2 | 5 | 127 | 47 | 80 | 63% | 2-1 | 1.93 | 0.79 |
| 2011-04-22 | Jon Lester | L | 27 | W 4-3 | @ ANA | 5 | 128 | W | 6.0 | 4 | 0 | 0 | 0 | 2 | 8 | 117 | 45 | 72 | 62% | 2-1 | 2.61 | 1.19 |
| 2011-04-23 | Daisuke Matsuzaka | R | 31 | W 5-0 | @ ANA | 4 | 102 | W | 8.0 | 1 | 0 | 0 | 0 | 3 | 9 | 114 | 37 | 77 | 68% | 2-2 | 4.09 | 1.14 |
| 2011-04-24 | John Lackey | R | 33 | W 7-0 | @ ANA | 4 | 270 | W | 8.0 | 6 | 0 | 0 | 0 | 1 | 6 | 110 | 37 | 73 | 66% | 2-2 | 6.26 | 1.43 |
| 2011-04-26 | Clay Buchholz | R | 27 | L 1-4 | @ BAL | 5 | 67 | L | 6.2 | 12 | 4 | 4 | 0 | 2 | 5 | 103 | 35 | 68 | 66% | 1-3 | 5.33 | 1.85 |
| 2011-04-27 | Josh Beckett | R | 31 | L 4-5 | @ BAL | 5 | 251 | - | 6.0 | 7 | 4 | 4 | 2 | 0 | 4 | 93 | 34 | 59 | 63% | 2-1 | 2.65 | 0.85 |
| 2011-04-28 | Jon Lester | L | 27 | W 6-2 | @ BAL | 6 | 129 | W | 8.0 | 4 | 2 | 2 | 1 | 3 | 5 | 109 | 45 | 64 | 59% | 3-1 | 2.54 | 1.13 |
| 2011-04-29 | Daisuke Matsuzaka | R | 31 | W 4-5 | vs SEA | 5 | 103 | - | 4.0 | 3 | 3 | 1 | 0 | 4 | 4 | 81 | 36 | 45 | 56% | 2-2 | 3.81 | 1.23 |
| 2011-04-30 | John Lackey | R | 33 | W 0-2 | vs SEA | 5 | 271 | L | 6.0 | 7 | 2 | 2 | 0 | 4 | 3 | 113 | 50 | 63 | 56% | 2-3 | 5.59 | 1.52 |
| 2011-05-01 | Tim Wakefield | R | 45 | L 3-2 | vs SEA | 1 | 441 | - | 5.2 | 3 | 1 | 1 | 0 | 1 | 3 | 74 | 22 | 52 | 70% | 0-0 | 4.24 | 0.88 |
| 2011-05-02 | Clay Buchholz | R | 27 | L 9-5 | vs ANA | 6 | 68 | W | 6.2 | 8 | 2 | 2 | 0 | 2 | 2 | 107 | 41 | 66 | 62% | 2-3 | 4.76 | 1.76 |
| 2011-05-03 | Jon Lester | L | 27 | L 7-3 | vs ANA | 7 | 130 | W | 7.0 | 6 | 1 | 1 | 1 | 1 | 11 | 92 | 27 | 65 | 71% | 4-1 | 2.35 | 1.11 |
| 2011-05-04 | Josh Beckett | R | 31 | W 3-5 | vs ANA | 6 | 252 | - | 4.1 | 1 | 0 | 0 | 0 | 3 | 3 | 68 | 30 | 38 | 56% | 2-1 | 2.37 | 0.87 |
| 2011-05-05 | John Lackey | R | 33 | W 0-11 | vs ANA | 6 | 272 | L | 4.0 | 10 | 8 | 8 | 1 | 3 | 1 | 97 | 38 | 59 | 61% | 2-4 | 7.09 | 1.73 |
| 2011-05-06 | Tim Wakefield | R | 45 | W 2-9 | vs MIN | 2 | 442 | L | 4.1 | 9 | 8 | 6 | 1 | 4 | 1 | 84 | 32 | 52 | 62% | 0-1 | 5.73 | 1.32 |
| 2011-05-07 | Clay Buchholz | R | 27 | L 4-0 | vs MIN | 7 | 69 | W | 5.0 | 2 | 0 | 0 | 0 | 1 | 6 | 60 | 17 | 43 | 72% | 3-3 | 4.15 | 1.62 |
| 2011-05-08 | Daisuke Matsuzaka | R | 31 | L 9-5 | vs MIN | 6 | 104 | W | 6.0 | 5 | 4 | 4 | 1 | 2 | 4 | 102 | 40 | 62 | 61% | 3-3 | 4.64 | 1.30 |
| 2011-05-09 | Josh Beckett | R | 31 | L 2-1 | vs MIN | 7 | 253 | - | 7.0 | 6 | 0 | 0 | 0 | 1 | 5 | 102 | 33 | 69 | 68% | 2-1 | 2.00 | 0.89 |
| 2011-05-10 | Jon Lester | L | 27 | L 6-7 | @ TOR | 8 | 131 | - | 5.1 | 7 | 5 | 5 | 2 | 5 | 5 | 115 | 47 | 68 | 59% | 4-1 | 2.94 | 1.21 |
| 2011-05-11 | John Lackey | R | 33 | L 3-9 | @ TOR | 7 | 273 | L | 6.2 | 9 | 9 | 9 | 1 | 5 | 1 | 124 | 61 | 63 | 51% | 2-5 | 8.08 | 1.82 |
| 2011-05-13 | Clay Buchholz | R | 27 | W 5-4 | @ NYA | 8 | 70 | W | 7.0 | 5 | 2 | 2 | 1 | 1 | 7 | 109 | 45 | 64 | 59% | 4-3 | 3.91 | 1.50 |
| 2011-05-14 | Josh Beckett | R | 31 | W 6-0 | @ NYA | 8 | 254 | W | 6.0 | 4 | 0 | 0 | 0 | 2 | 9 | 109 | 43 | 66 | 61% | 3-1 | 1.76 | 0.90 |
| 2011-05-15 | Jon Lester | L | 27 | W 7-5 | @ NYA | 9 | 132 | W | 6.0 | 5 | 4 | 4 | 2 | 4 | 7 | 109 | 47 | 62 | 57% | 5-1 | 3.26 | 1.24 |
| 2011-05-16 | Daisuke Matsuzaka | R | 31 | L 8-7 | vs BAL | 7 | 105 | - | 4.1 | 5 | 5 | 5 | 0 | 7 | 2 | 103 | 49 | 54 | 52% | 3-3 | 5.35 | 1.49 |
| 2011-05-18 | Clay Buchholz | R | 27 | L 1-0 | vs DET | 9 | 71 | - | 7.0 | 4 | 0 | 0 | 0 | 1 | 7 | 126 | 48 | 78 | 62% | 4-3 | 3.40 | 1.40 |
| 2011-05-19 | Josh Beckett | R | 31 | L 4-3 | vs DET | 9 | 255 | - | 6.0 | 5 | 1 | 1 | 0 | 2 | 3 | 83 | 31 | 52 | 63% | 3-1 | 1.74 | 0.93 |
| 2011-05-20 | Jon Lester | L | 27 | L 15-5 | vs CHN | 10 | 133 | W | 6.0 | 12 | 5 | 5 | 0 | 2 | 5 | 103 | 31 | 72 | 70% | 6-1 | 3.66 | 1.34 |
| 2011-05-21 | Alfredo Aceves | R | 28 | W 3-9 | vs CHN | 1 | 6 | - | 5.0 | 3 | 1 | 1 | 0 | 2 | 2 | 85 | 30 | 55 | 65% | 1-0 | 2.45 | 1.05 |
| 2011-05-22 | Tim Wakefield | R | 45 | L 5-1 | vs CHN | 3 | 443 | W | 6.2 | 4 | 1 | 1 | 0 | 0 | 3 | 74 | 20 | 54 | 73% | 1-1 | 4.50 | 1.20 |
| 2011-05-23 | Clay Buchholz | R | 27 | L 2-3 | @ CLE | 10 | 72 | - | 7.1 | 4 | 2 | 2 | 1 | 2 | 4 | 98 | 42 | 56 | 57% | 4-3 | 3.30 | 1.33 |
| 2011-05-24 | Josh Beckett | R | 31 | W 4-2 | @ CLE | 10 | 256 | W | 6.2 | 5 | 1 | 1 | 0 | 3 | 6 | 115 | 44 | 71 | 62% | 4-1 | 1.69 | 0.95 |
| 2011-05-25 | Jon Lester | L | 27 | W 14-2 | @ CLE | 11 | 134 | W | 6.0 | 3 | 0 | 0 | 0 | 1 | 7 | 94 | 34 | 60 | 64% | 7-1 | 3.34 | 1.29 |
| 2011-05-26 | Alfredo Aceves | R | 28 | W 14-1 | @ DET | 2 | 7 | W | 6.0 | 5 | 1 | 1 | 0 | 2 | 6 | 100 | 35 | 65 | 65% | 2-0 | 2.25 | 1.07 |
| 2011-05-27 | Tim Wakefield | R | 45 | W 6-3 | @ DET | 4 | 444 | W | 7.0 | 5 | 2 | 2 | 1 | 2 | 2 | 86 | 27 | 59 | 69% | 2-1 | 4.14 | 1.16 |
| 2011-05-29 | Clay Buchholz | R | 27 | W 4-3 | @ DET | 11 | 73 | - | 6.0 | 6 | 3 | 3 | 2 | 1 | 3 | 98 | 35 | 63 | 64% | 4-3 | 3.41 | 1.32 |
| 2011-05-29 | Josh Beckett | R | 31 | L 0-3 | @ DET | 11 | 257 | L | 6.0 | 5 | 2 | 2 | 0 | 5 | 5 | 107 | 42 | 65 | 61% | 4-2 | 1.80 | 1.01 |
| 2011-05-30 | Jon Lester | L | 27 | W 3-7 | vs CHA | 12 | 135 | L | 5.2 | 8 | 7 | 7 | 1 | 4 | 4 | 126 | 55 | 71 | 56% | 7-2 | 3.96 | 1.36 |
| 2011-05-31 | Alfredo Aceves | R | 28 | W 7-10 | vs CHA | 3 | 8 | L | 5.0 | 8 | 8 | 6 | 0 | 3 | 1 | 78 | 31 | 47 | 60% | 2-1 | 3.55 | 1.24 |
| 2011-06-01 | Tim Wakefield | R | 45 | W 4-7 | vs CHA | 5 | 445 | - | 6.0 | 7 | 4 | 4 | 1 | 1 | 4 | 98 | 31 | 67 | 68% | 2-1 | 4.40 | 1.19 |
| 2011-06-03 | Clay Buchholz | R | 27 | L 8-6 | vs OAK | 12 | 74 | - | 4.2 | 8 | 6 | 5 | 0 | 2 | 5 | 98 | 37 | 61 | 62% | 4-3 | 3.80 | 1.37 |
| 2011-06-04 | Josh Beckett | R | 31 | L 9-8 | vs OAK | 12 | 258 | - | 6.0 | 4 | 3 | 3 | 0 | 3 | 4 | 101 | 44 | 57 | 56% | 4-2 | 2.01 | 1.03 |
| 2011-06-05 | John Lackey | R | 33 | L 6-3 | vs OAK | 8 | 274 | W | 5.2 | 3 | 3 | 3 | 1 | 2 | 2 | 93 | 39 | 54 | 58% | 3-5 | 7.60 | 1.69 |
| 2011-06-07 | Jon Lester | L | 27 | W 6-4 | @ NYA | 13 | 136 | W | 6.0 | 8 | 3 | 3 | 0 | 1 | 5 | 112 | 46 | 66 | 59% | 8-2 | 4.00 | 1.37 |
| 2011-06-08 | Tim Wakefield | R | 45 | W 11-6 | @ NYA | 6 | 446 | W | 5.1 | 5 | 5 | 5 | 1 | 3 | 3 | 94 | 37 | 57 | 61% | 3-1 | 4.88 | 1.23 |
| 2011-06-09 | Josh Beckett | R | 31 | W 8-3 | @ NYA | 13 | 259 | W | 7.0 | 4 | 2 | 2 | 1 | 2 | 6 | 105 | 40 | 65 | 62% | 5-2 | 2.06 | 1.01 |
| 2011-06-10 | Clay Buchholz | R | 27 | W 5-1 | @ TOR | 13 | 75 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 6 | 103 | 40 | 63 | 61% | 5-3 | 3.58 | 1.31 |
| 2011-06-11 | John Lackey | R | 33 | W 16-4 | @ TOR | 9 | 275 | W | 6.0 | 6 | 4 | 4 | 1 | 2 | 8 | 112 | 42 | 70 | 63% | 4-5 | 7.41 | 1.65 |
| 2011-06-12 | Jon Lester | L | 27 | W 14-1 | @ TOR | 14 | 137 | W | 8.0 | 2 | 1 | 1 | 1 | 1 | 8 | 101 | 34 | 67 | 66% | 9-2 | 3.74 | 1.28 |
| 2011-06-14 | Tim Wakefield | R | 45 | L 0-4 | @ TBA | 7 | 447 | L | 7.0 | 4 | 2 | 1 | 1 | 5 | 2 | 127 | 53 | 74 | 58% | 3-2 | 4.42 | 1.24 |
| 2011-06-15 | Josh Beckett | R | 31 | W 3-0 | @ TBA | 14 | 260 | W | 9.0 | 1 | 0 | 0 | 0 | 0 | 6 | 99 | 31 | 68 | 69% | 6-2 | 1.86 | 0.92 |
| 2011-06-16 | Clay Buchholz | R | 27 | W 4-2 | @ TBA | 14 | 76 | W | 5.0 | 2 | 1 | 1 | 0 | 3 | 5 | 84 | 33 | 51 | 61% | 6-3 | 3.47 | 1.29 |
| 2011-06-17 | John Lackey | R | 33 | L 10-4 | vs MIL | 10 | 276 | W | 8.0 | 8 | 4 | 4 | 0 | 0 | 5 | 110 | 30 | 80 | 73% | 5-5 | 7.02 | 1.56 |
| 2011-06-18 | Jon Lester | L | 27 | W 2-4 | vs MIL | 15 | 138 | L | 8.0 | 7 | 4 | 3 | 3 | 3 | 8 | 113 | 43 | 70 | 62% | 9-3 | 3.71 | 1.28 |
| 2011-06-19 | Tim Wakefield | R | 45 | L 12-3 | vs MIL | 8 | 448 | W | 8.0 | 3 | 3 | 3 | 2 | 1 | 6 | 97 | 24 | 73 | 75% | 4-2 | 4.29 | 1.14 |
| 2011-06-20 | Andrew Miller | L | 26 | L 14-5 | vs SDN | 1 | 55 | - | 5.2 | 7 | 3 | 3 | 1 | 3 | 6 | 89 | 31 | 58 | 65% | 0-0 | 4.50 | 1.67 |
| 2011-06-21 | Alfredo Aceves | R | 29 | W 4-5 | vs SDN | 4 | 9 | - | 5.0 | 4 | 4 | 4 | 0 | 6 | 4 | 96 | 46 | 50 | 52% | 3-1 | 3.67 | 1.31 |
| 2011-06-22 | John Lackey | R | 33 | W 1-5 | vs SDN | 11 | 277 | L | 3.1 | 4 | 5 | 5 | 1 | 4 | 4 | 81 | 35 | 46 | 57% | 5-6 | 7.40 | 1.61 |
| 2011-06-24 | Jon Lester | L | 27 | L 1-3 | @ PIT | 16 | 139 | L | 6.0 | 8 | 3 | 2 | 0 | 1 | 5 | 107 | 37 | 70 | 65% | 9-4 | 3.67 | 1.29 |
| 2011-06-25 | Tim Wakefield | R | 45 | L 4-6 | @ PIT | 9 | 449 | L | 6.0 | 7 | 5 | 5 | 1 | 4 | 2 | 90 | 41 | 49 | 54% | 4-3 | 4.57 | 1.20 |
| 2011-06-26 | Andrew Miller | L | 26 | W 4-2 | @ PIT | 2 | 56 | W | 6.0 | 5 | 2 | 1 | 0 | 2 | 4 | 108 | 37 | 71 | 66% | 1-0 | 3.00 | 1.42 |
| 2011-06-28 | Josh Beckett | R | 31 | L 0-5 | @ PHI | 15 | 261 | L | 6.0 | 5 | 5 | 5 | 2 | 1 | 1 | 88 | 32 | 56 | 64% | 6-3 | 2.20 | 0.93 |
| 2011-06-29 | John Lackey | R | 33 | L 1-2 | @ PHI | 12 | 278 | L | 7.2 | 8 | 2 | 2 | 1 | 1 | 5 | 88 | 26 | 62 | 70% | 5-7 | 6.81 | 1.56 |
| 2011-06-30 | Jon Lester | L | 27 | W 5-2 | @ PHI | 17 | 140 | W | 7.0 | 2 | 0 | 0 | 0 | 2 | 5 | 123 | 46 | 77 | 63% | 10-4 | 3.44 | 1.25 |
| 2011-07-01 | Tim Wakefield | R | 45 | W 7-5 | @ HOU | 10 | 450 | - | 5.1 | 11 | 5 | 5 | 0 | 0 | 0 | 97 | 27 | 70 | 72% | 4-3 | 4.80 | 1.25 |
| 2011-07-02 | Andrew Miller | L | 26 | W 10-4 | @ HOU | 3 | 57 | W | 6.0 | 7 | 2 | 2 | 1 | 2 | 3 | 84 | 30 | 54 | 64% | 2-0 | 3.00 | 1.44 |
| 2011-07-03 | Josh Beckett | R | 31 | W 2-1 | @ HOU | 16 | 262 | W | 8.0 | 5 | 1 | 1 | 0 | 0 | 11 | 106 | 34 | 72 | 68% | 7-3 | 2.12 | 0.91 |
| 2011-07-04 | John Lackey | R | 33 | W 7-9 | vs TOR | 13 | 279 | L | 2.1 | 9 | 7 | 7 | 1 | 0 | 2 | 65 | 24 | 41 | 63% | 5-8 | 7.50 | 1.64 |
| 2011-07-05 | Jon Lester | L | 27 | L 3-2 | vs TOR | 18 | 141 | - | 4.0 | 0 | 0 | 0 | 0 | 1 | 5 | 47 | 15 | 32 | 68% | 10-4 | 3.32 | 1.21 |
| 2011-07-06 | Tim Wakefield | R | 45 | L 6-4 | vs TOR | 11 | 451 | W | 7.0 | 9 | 3 | 3 | 0 | 1 | 7 | 104 | 30 | 74 | 71% | 5-3 | 4.72 | 1.27 |
| 2011-07-07 | Andrew Miller | L | 26 | L 10-4 | vs BAL | 4 | 58 | W | 5.0 | 6 | 3 | 3 | 0 | 4 | 0 | 97 | 41 | 56 | 58% | 3-0 | 3.52 | 1.57 |
| 2011-07-08 | Josh Beckett | R | 31 | L 10-3 | vs BAL | 17 | 263 | W | 5.0 | 7 | 3 | 3 | 1 | 2 | 3 | 67 | 18 | 49 | 73% | 8-3 | 2.27 | 0.95 |
| 2011-07-09 | John Lackey | R | 33 | L 4-0 | vs BAL | 14 | 280 | W | 6.2 | 3 | 0 | 0 | 0 | 1 | 7 | 104 | 36 | 68 | 65% | 6-8 | 6.84 | 1.54 |
| 2011-07-10 | Kyle Weiland | R | 25 | L 8-6 | vs BAL | 1 | 1 | - | 4.0 | 8 | 6 | 6 | 1 | 2 | 2 | 77 | 36 | 41 | 53% | 0-0 | 13.50 | 2.50 |
| 2011-07-15 | Andrew Miller | L | 26 | L 6-9 | @ TBA | 5 | 59 | L | 2.2 | 5 | 7 | 7 | 1 | 5 | 0 | 85 | 34 | 51 | 60% | 3-1 | 5.76 | 1.84 |
| 2011-07-16 | John Lackey | R | 33 | W 9-5 | @ TBA | 15 | 281 | W | 5.2 | 10 | 4 | 3 | 1 | 1 | 7 | 111 | 37 | 74 | 67% | 7-8 | 6.67 | 1.56 |
| 2011-07-17 | Josh Beckett | R | 31 | W 1-0 | @ TBA | 18 | 264 | - | 8.0 | 1 | 0 | 0 | 0 | 0 | 6 | 106 | 35 | 71 | 67% | 8-3 | 2.12 | 0.89 |
| 2011-07-18 | Tim Wakefield | R | 45 | W 15-10 | @ BAL | 12 | 452 | - | 4.2 | 9 | 7 | 3 | 2 | 2 | 3 | 95 | 36 | 59 | 62% | 5-3 | 4.81 | 1.34 |
| 2011-07-19 | Kyle Weiland | R | 25 | L 2-6 | @ BAL | 2 | 2 | L | 6.0 | 6 | 3 | 3 | 0 | 3 | 2 | 98 | 39 | 59 | 60% | 0-1 | 8.10 | 1.90 |
| 2011-07-20 | Andrew Miller | L | 26 | W 4-0 | @ BAL | 6 | 60 | W | 5.2 | 2 | 0 | 0 | 0 | 6 | 3 | 103 | 43 | 60 | 58% | 4-1 | 4.65 | 1.74 |
| 2011-07-22 | John Lackey | R | 33 | L 7-4 | vs SEA | 16 | 282 | W | 7.0 | 8 | 1 | 1 | 0 | 0 | 4 | 101 | 33 | 68 | 67% | 8-8 | 6.26 | 1.53 |
| 2011-07-23 | Josh Beckett | R | 31 | L 3-1 | vs SEA | 19 | 265 | W | 7.0 | 7 | 1 | 1 | 1 | 1 | 7 | 117 | 37 | 80 | 68% | 9-3 | 2.07 | 0.90 |
| 2011-07-24 | Tim Wakefield | R | 45 | L 12-8 | vs SEA | 13 | 453 | W | 6.1 | 10 | 7 | 7 | 2 | 1 | 4 | 97 | 28 | 69 | 71% | 6-3 | 5.13 | 1.35 |
| 2011-07-25 | Jon Lester | L | 28 | W 1-3 | vs KCA | 19 | 142 | - | 5.1 | 7 | 1 | 1 | 0 | 2 | 6 | 82 | 31 | 51 | 62% | 10-4 | 3.23 | 1.23 |
| 2011-07-26 | Andrew Miller | L | 26 | L 13-9 | vs KCA | 7 | 61 | - | 3.2 | 9 | 7 | 5 | 2 | 2 | 1 | 78 | 37 | 41 | 53% | 4-1 | 5.40 | 1.86 |
| 2011-07-27 | John Lackey | R | 33 | L 12-5 | vs KCA | 17 | 283 | W | 5.2 | 11 | 4 | 3 | 2 | 1 | 3 | 111 | 35 | 76 | 68% | 9-8 | 6.22 | 1.58 |
| 2011-07-28 | Josh Beckett | R | 31 | W 3-4 | vs KCA | 20 | 266 | L | 7.0 | 5 | 4 | 3 | 1 | 3 | 8 | 109 | 37 | 72 | 66% | 9-4 | 2.17 | 0.92 |
| 2011-07-29 | Tim Wakefield | R | 45 | L 1-3 | @ CHA | 14 | 454 | L | 7.0 | 3 | 3 | 3 | 1 | 2 | 5 | 103 | 36 | 67 | 65% | 6-4 | 5.04 | 1.31 |
| 2011-07-30 | Jon Lester | L | 28 | W 10-2 | @ CHA | 20 | 143 | W | 8.0 | 4 | 2 | 2 | 2 | 1 | 8 | 93 | 32 | 61 | 66% | 11-4 | 3.16 | 1.19 |
| 2011-07-31 | Andrew Miller | L | 26 | W 5-3 | @ CHA | 8 | 62 | - | 5.2 | 10 | 3 | 3 | 0 | 1 | 8 | 104 | 34 | 70 | 67% | 4-1 | 5.40 | 1.90 |
| 2011-08-01 | John Lackey | R | 33 | W 6-9 | vs CLE | 18 | 284 | - | 6.2 | 8 | 5 | 5 | 2 | 0 | 5 | 104 | 31 | 73 | 70% | 9-8 | 6.23 | 1.55 |
| 2011-08-02 | Josh Beckett | R | 31 | L 3-2 | vs CLE | 21 | 267 | - | 6.0 | 6 | 2 | 2 | 2 | 0 | 7 | 85 | 25 | 60 | 71% | 9-4 | 2.20 | 0.92 |
| 2011-08-03 | Tim Wakefield | R | 45 | L 4-3 | vs CLE | 15 | 455 | - | 6.2 | 5 | 3 | 3 | 1 | 2 | 6 | 96 | 34 | 62 | 65% | 6-4 | 5.01 | 1.30 |
| 2011-08-04 | Erik Bedard | L | 32 | W 3-7 | vs CLE | 17 | 158 | - | 5.0 | 7 | 3 | 3 | 0 | 0 | 5 | 69 | 21 | 48 | 70% | 4-7 | 3.56 | 1.19 |
| 2011-08-05 | Jon Lester | L | 28 | W 2-3 | vs NYA | 21 | 144 | L | 6.0 | 5 | 3 | 3 | 0 | 4 | 7 | 108 | 44 | 64 | 59% | 11-5 | 3.22 | 1.20 |
| 2011-08-06 | John Lackey | R | 33 | L 10-4 | vs NYA | 19 | 285 | W | 6.0 | 6 | 3 | 3 | 0 | 2 | 5 | 115 | 44 | 71 | 62% | 10-8 | 6.14 | 1.54 |
| 2011-08-07 | Josh Beckett | R | 31 | L 3-2 | vs NYA | 22 | 268 | - | 6.0 | 6 | 1 | 1 | 1 | 2 | 5 | 101 | 41 | 60 | 59% | 9-4 | 2.17 | 0.94 |
| 2011-08-08 | Tim Wakefield | R | 45 | W 8-6 | @ MIN | 16 | 456 | - | 7.0 | 8 | 5 | 3 | 1 | 0 | 4 | 103 | 29 | 74 | 72% | 6-4 | 4.94 | 1.29 |
| 2011-08-09 | Erik Bedard | L | 32 | W 4-3 | @ MIN | 18 | 159 | - | 5.0 | 3 | 2 | 2 | 0 | 4 | 6 | 90 | 39 | 51 | 57% | 4-7 | 3.56 | 1.20 |
| 2011-08-10 | Jon Lester | L | 28 | L 2-5 | @ MIN | 22 | 145 | L | 7.1 | 8 | 4 | 4 | 0 | 5 | 4 | 122 | 48 | 74 | 61% | 11-6 | 3.32 | 1.23 |
| 2011-08-12 | John Lackey | R | 33 | W 6-4 | @ SEA | 20 | 286 | W | 6.0 | 10 | 4 | 4 | 0 | 2 | 3 | 117 | 47 | 70 | 60% | 11-8 | 6.13 | 1.56 |
| 2011-08-13 | Josh Beckett | R | 31 | L 4-5 | @ SEA | 23 | 269 | L | 5.0 | 8 | 5 | 5 | 2 | 1 | 6 | 95 | 36 | 59 | 62% | 9-5 | 2.40 | 0.97 |
| 2011-08-14 | Tim Wakefield | R | 45 | L 3-5 | @ SEA | 17 | 457 | L | 8.0 | 9 | 5 | 4 | 1 | 2 | 4 | 98 | 27 | 71 | 72% | 6-5 | 4.91 | 1.30 |
| 2011-08-16 | Jon Lester | L | 28 | L 3-1 | vs TBA | 23 | 146 | W | 7.0 | 3 | 1 | 1 | 0 | 1 | 8 | 112 | 48 | 64 | 57% | 12-6 | 3.22 | 1.20 |
| 2011-08-16 | Erik Bedard | L | 32 | W 2-6 | vs TBA | 19 | 160 | L | 6.0 | 7 | 3 | 1 | 1 | 0 | 6 | 100 | 30 | 70 | 70% | 4-8 | 3.45 | 1.20 |
| 2011-08-17 | John Lackey | R | 33 | W 0-4 | vs TBA | 21 | 287 | L | 6.2 | 6 | 4 | 3 | 2 | 3 | 7 | 124 | 50 | 74 | 60% | 11-9 | 6.00 | 1.54 |
| 2011-08-18 | Josh Beckett | R | 31 | W 4-3 | @ KCA | 24 | 270 | W | 7.0 | 7 | 3 | 3 | 1 | 0 | 4 | 107 | 34 | 73 | 68% | 10-5 | 2.46 | 0.97 |
| 2011-08-19 | Andrew Miller | L | 26 | W 7-1 | @ KCA | 9 | 63 | W | 5.1 | 3 | 1 | 1 | 0 | 2 | 3 | 83 | 33 | 50 | 60% | 5-1 | 4.96 | 1.80 |
| 2011-08-20 | Tim Wakefield | R | 45 | L 4-9 | @ KCA | 18 | 458 | - | 5.1 | 9 | 4 | 4 | 0 | 0 | 3 | 100 | 34 | 66 | 66% | 6-5 | 4.96 | 1.31 |
| 2011-08-21 | Jon Lester | L | 28 | W 6-1 | @ KCA | 24 | 147 | W | 6.0 | 3 | 1 | 1 | 0 | 4 | 3 | 112 | 44 | 68 | 61% | 13-6 | 3.16 | 1.20 |
| 2011-08-22 | Erik Bedard | L | 32 | L 0-4 | @ TEX | 20 | 161 | L | 6.0 | 7 | 4 | 4 | 1 | 1 | 4 | 110 | 41 | 69 | 63% | 4-9 | 3.58 | 1.20 |
| 2011-08-23 | John Lackey | R | 33 | W 11-5 | @ TEX | 22 | 288 | W | 6.2 | 7 | 4 | 4 | 1 | 3 | 5 | 106 | 42 | 64 | 60% | 12-9 | 6.00 | 1.55 |
| 2011-08-24 | Josh Beckett | R | 31 | W 13-2 | @ TEX | 25 | 271 | W | 6.0 | 4 | 1 | 1 | 1 | 2 | 4 | 109 | 44 | 65 | 60% | 11-5 | 2.43 | 0.97 |
| 2011-08-25 | Andrew Miller | L | 26 | W 6-0 | @ TEX | 10 | 64 | W | 6.1 | 3 | 0 | 0 | 0 | 2 | 6 | 83 | 32 | 51 | 61% | 6-1 | 4.42 | 1.69 |
| 2011-08-26 | Tim Wakefield | R | 45 | W 5-15 | vs OAK | 19 | 459 | L | 4.0 | 8 | 8 | 4 | 2 | 2 | 3 | 90 | 29 | 61 | 68% | 6-6 | 5.08 | 1.34 |
| 2011-08-27 | Jon Lester | L | 28 | L 9-3 | vs OAK | 25 | 148 | W | 6.0 | 3 | 2 | 1 | 1 | 2 | 4 | 87 | 34 | 53 | 61% | 14-6 | 3.09 | 1.19 |
| 2011-08-27 | Erik Bedard | L | 32 | L 4-0 | vs OAK | 21 | 162 | - | 4.0 | 2 | 0 | 0 | 0 | 4 | 5 | 78 | 30 | 48 | 62% | 4-9 | 3.46 | 1.21 |
| 2011-08-30 | John Lackey | R | 33 | W 2-5 | vs NYA | 23 | 289 | L | 7.0 | 7 | 5 | 4 | 1 | 4 | 3 | 118 | 44 | 74 | 63% | 12-10 | 5.96 | 1.55 |
| 2011-08-31 | Josh Beckett | R | 31 | L 9-5 | vs NYA | 26 | 272 | W | 7.0 | 6 | 5 | 4 | 0 | 3 | 8 | 109 | 39 | 70 | 64% | 12-5 | 2.54 | 0.98 |
| 2011-09-01 | Jon Lester | L | 28 | W 2-4 | vs NYA | 26 | 149 | - | 5.0 | 7 | 1 | 1 | 0 | 3 | 6 | 113 | 41 | 72 | 64% | 14-6 | 3.05 | 1.21 |
| 2011-09-02 | Andrew Miller | L | 26 | W 0-10 | vs TEX | 11 | 65 | L | 1.1 | 5 | 6 | 6 | 1 | 4 | 1 | 52 | 26 | 26 | 50% | 6-2 | 5.30 | 1.82 |
| 2011-09-03 | Erik Bedard | L | 32 | L 12-7 | vs TEX | 22 | 163 | W | 6.0 | 5 | 3 | 3 | 0 | 4 | 6 | 100 | 42 | 58 | 58% | 5-9 | 3.51 | 1.23 |
| 2011-09-04 | John Lackey | R | 33 | W 4-11 | vs TEX | 24 | 290 | L | 5.0 | 8 | 6 | 6 | 0 | 3 | 1 | 102 | 42 | 60 | 59% | 12-11 | 6.13 | 1.57 |
| 2011-09-05 | Josh Beckett | R | 31 | L 0-1 | @ TOR | 27 | 273 | - | 3.2 | 3 | 0 | 0 | 0 | 1 | 6 | 63 | 18 | 45 | 71% | 12-5 | 2.48 | 0.98 |
| 2011-09-06 | Jon Lester | L | 28 | W 14-0 | @ TOR | 27 | 150 | W | 7.0 | 3 | 0 | 0 | 0 | 1 | 11 | 99 | 34 | 65 | 66% | 15-6 | 2.93 | 1.19 |
| 2011-09-07 | Tim Wakefield | R | 45 | L 10-11 | @ TOR | 20 | 460 | - | 5.0 | 3 | 5 | 4 | 1 | 3 | 3 | 100 | 50 | 50 | 50% | 6-6 | 5.01 | 1.32 |
| 2011-09-08 | Andrew Miller | L | 26 | L 4-7 | @ TOR | 12 | 66 | L | 5.0 | 8 | 5 | 5 | 2 | 2 | 3 | 93 | 38 | 55 | 59% | 6-3 | 5.61 | 1.84 |
| 2011-09-09 | John Lackey | R | 33 | L 2-7 | @ TBA | 25 | 291 | L | 3.0 | 5 | 5 | 5 | 1 | 3 | 2 | 71 | 29 | 42 | 59% | 12-12 | 6.31 | 1.60 |
| 2011-09-10 | Kyle Weiland | R | 25 | L 5-6 | @ TBA | 3 | 3 | - | 4.0 | 6 | 3 | 3 | 0 | 3 | 1 | 82 | 36 | 46 | 56% | 0-1 | 6.75 | 1.81 |
| 2011-09-11 | Jon Lester | L | 28 | L 1-9 | @ TBA | 28 | 151 | L | 4.0 | 8 | 4 | 4 | 0 | 3 | 2 | 115 | 46 | 69 | 60% | 15-7 | 3.07 | 1.22 |
| 2011-09-13 | Tim Wakefield | R | 45 | L 18-6 | vs TOR | 21 | 461 | W | 6.0 | 6 | 5 | 5 | 2 | 2 | 6 | 95 | 34 | 61 | 64% | 7-6 | 5.12 | 1.32 |
| 2011-09-14 | John Lackey | R | 33 | W 4-5 | vs TOR | 26 | 292 | - | 5.1 | 7 | 2 | 2 | 0 | 1 | 4 | 112 | 36 | 76 | 68% | 12-12 | 6.18 | 1.59 |
| 2011-09-15 | Kyle Weiland | R | 25 | W 2-9 | vs TBA | 4 | 4 | L | 3.0 | 3 | 4 | 4 | 1 | 2 | 1 | 61 | 29 | 32 | 52% | 0-2 | 7.58 | 1.79 |
| 2011-09-16 | Josh Beckett | R | 31 | L 4-3 | vs TBA | 28 | 274 | W | 6.0 | 7 | 3 | 2 | 1 | 1 | 7 | 108 | 42 | 66 | 61% | 13-5 | 2.50 | 0.99 |
| 2011-09-17 | Jon Lester | L | 28 | W 3-4 | vs TBA | 29 | 152 | L | 7.0 | 5 | 4 | 4 | 1 | 4 | 5 | 107 | 44 | 63 | 59% | 15-8 | 3.15 | 1.22 |
| 2011-09-18 | Tim Wakefield | R | 45 | W 5-8 | vs TBA | 22 | 462 | L | 5.0 | 6 | 6 | 2 | 0 | 1 | 5 | 103 | 38 | 65 | 63% | 7-7 | 5.07 | 1.32 |
| 2011-09-19 | Kyle Weiland | R | 25 | W 5-6 | vs BAL | 5 | 5 | L | 4.2 | 5 | 6 | 5 | 3 | 2 | 5 | 83 | 33 | 50 | 60% | 0-3 | 7.88 | 1.71 |
| 2011-09-19 | John Lackey | R | 33 | L 18-9 | vs BAL | 27 | 293 | - | 4.1 | 11 | 8 | 8 | 0 | 2 | 3 | 105 | 30 | 75 | 71% | 12-12 | 6.49 | 1.63 |
| 2011-09-20 | Erik Bedard | L | 33 | W 5-7 | vs BAL | 23 | 164 | - | 2.2 | 5 | 4 | 1 | 0 | 2 | 0 | 75 | 29 | 46 | 61% | 5-9 | 3.50 | 1.25 |
| 2011-09-21 | Josh Beckett | R | 31 | W 4-6 | vs BAL | 29 | 275 | L | 7.1 | 7 | 6 | 6 | 2 | 1 | 8 | 109 | 32 | 77 | 71% | 13-6 | 2.70 | 1.00 |
| 2011-09-24 | Jon Lester | L | 28 | L 1-9 | @ NYA | 30 | 153 | L | 2.2 | 8 | 8 | 8 | 1 | 1 | 3 | 53 | 23 | 30 | 57% | 15-9 | 3.48 | 1.25 |
| 2011-09-25 | Tim Wakefield | R | 45 | L 2-6 | @ NYA | 23 | 463 | L | 4.0 | 5 | 5 | 3 | 1 | 5 | 4 | 98 | 43 | 55 | 56% | 7-8 | 5.11 | 1.35 |
| 2011-09-25 | John Lackey | R | 33 | W 7-4 | @ NYA | 28 | 294 | - | 6.0 | 5 | 3 | 3 | 0 | 3 | 4 | 86 | 29 | 57 | 66% | 12-12 | 6.41 | 1.62 |
| 2011-09-26 | Josh Beckett | R | 31 | L 3-6 | @ BAL | 30 | 276 | L | 6.0 | 7 | 6 | 6 | 2 | 4 | 5 | 110 | 39 | 71 | 65% | 13-7 | 2.89 | 1.03 |
| 2011-09-27 | Erik Bedard | L | 33 | W 8-7 | @ BAL | 24 | 165 | - | 3.1 | 5 | 3 | 3 | 1 | 3 | 6 | 91 | 39 | 52 | 57% | 5-9 | 3.63 | 1.29 |
| 2011-09-28 | Jon Lester | L | 28 | L 3-4 | @ BAL | 31 | 154 | - | 6.0 | 4 | 2 | 2 | 1 | 4 | 5 | 93 | 39 | 54 | 58% | 15-9 | 3.47 | 1.26 |