| 2011-03-31 | vs SDN | 1 | L 3-5 | 0-1 | 3 | 46,368 | Chris Carpenter | Tim Stauffer | Pat Neshek | Bryan Augenstein | Heath Bell | 3 | 5 | -2 |
| 2011-04-02 | vs SDN | 2 | L 3-11 | 0-2 | 6 | 38,527 | Jake Westbrook | Clayton Richard | Clayton Richard | Jake Westbrook | | 6 | 16 | -10 |
| 2011-04-03 | vs SDN | 3 | W 2-0 | 1-2 | 4 | 36,414 | Jaime Garcia | Dustin Moseley | Jaime Garcia | Dustin Moseley | | 8 | 16 | -8 |
| 2011-04-04 | vs PIT | 4 | L 3-4 | 1-3 | 4 | 32,007 | Kyle Lohse | Charlie Morton | Charlie Morton | Kyle Lohse | Joel Hanrahan | 11 | 20 | -9 |
| 2011-04-05 | vs PIT | 5 | W 3-2 | 2-3 | 4 | 33,666 | Kyle McClellan | James McDonald | Miguel Batista | Garrett Olson | Ryan Franklin | 14 | 22 | -8 |
| 2011-04-06 | vs PIT | 6 | L 1-3 | 2-4 | 5 | 34,965 | Chris Carpenter | Kevin Correia | Kevin Correia | Chris Carpenter | Joel Hanrahan | 15 | 25 | -10 |
| 2011-04-08 | @ SFN | 7 | L 4-5 | 2-5 | 5 | 42,048 | Jake Westbrook | Jonathan Sanchez | Dan Runzler | Brian Tallet | | 19 | 30 | -11 |
| 2011-04-09 | @ SFN | 8 | L 2-3 | 2-6 | 5 | 41,742 | Jaime Garcia | Matt Cain | Ramon Ramirez | Ryan Franklin | | 21 | 33 | -12 |
| 2011-04-10 | @ SFN | 9 | W 6-1 | 3-6 | 5 | 42,092 | Kyle Lohse | Barry Zito | Kyle Lohse | Barry Zito | | 27 | 34 | -7 |
| 2011-04-11 | @ ARI | 10 | W 8-2 | 4-6 | 5 | 15,746 | Kyle McClellan | Barry Enright | Kyle McClellan | Barry Enright | | 35 | 36 | -1 |
| 2011-04-12 | @ ARI | 11 | L 8-13 | 4-7 | 5 | 16,645 | Chris Carpenter | Armando Galarraga | Armando Galarraga | Chris Carpenter | | 43 | 49 | -6 |
| 2011-04-13 | @ ARI | 12 | W 15-5 | 5-7 | 5 | 17,660 | Jake Westbrook | Ian Kennedy | Jake Westbrook | Ian Kennedy | | 58 | 54 | 4 |
| 2011-04-14 | @ LAN | 13 | W 9-5 | 6-7 | 4 | 34,288 | Jaime Garcia | Hiroki Kuroda | Jaime Garcia | Hiroki Kuroda | | 67 | 59 | 8 |
| 2011-04-15 | @ LAN | 14 | W 11-2 | 7-7 | 3 | 36,282 | Kyle Lohse | Jon Garland | Kyle Lohse | Jon Garland | | 78 | 61 | 17 |
| 2011-04-16 | @ LAN | 15 | W 9-2 | 8-7 | 3 | 31,614 | Kyle McClellan | Clayton Kershaw | Kyle McClellan | Clayton Kershaw | | 87 | 63 | 24 |
| 2011-04-17 | @ LAN | 16 | L 1-2 | 8-8 | 3 | 27,439 | Chris Carpenter | Chad Billingsley | Jonathan Broxton | Ryan Franklin | | 88 | 65 | 23 |
| 2011-04-20 | vs WAS | 17 | L 6-8 | 8-9 | 6 | 32,340 | Jake Westbrook | John Lannan | John Lannan | Jake Westbrook | Drew Storen | 94 | 73 | 21 |
| 2011-04-20 | vs WAS | 18 | W 5-3 | 8-9 | 6 | 33,714 | Jaime Garcia | Jordan Zimmermann | Jaime Garcia | Jordan Zimmermann | Mitchell Boggs | 99 | 76 | 23 |
| 2011-04-21 | vs WAS | 19 | W 5-0 | 10-9 | 3 | 36,160 | Kyle Lohse | Tom Gorzelanny | Kyle Lohse | Tom Gorzelanny | | 104 | 76 | 28 |
| 2011-04-22 | vs CIN | 20 | W 4-2 | 11-9 | 1 | 40,327 | Miguel Batista | Edinson Volquez | Kyle McClellan | Matt Maloney | Mitchell Boggs | 108 | 78 | 30 |
| 2011-04-23 | vs CIN | 21 | L 3-5 | 11-10 | 2 | 41,877 | Chris Carpenter | Travis Wood | Aroldis Chapman | Miguel Batista | Francisco Cordero | 111 | 83 | 28 |
| 2011-04-24 | vs CIN | 22 | W 3-0 | 12-10 | 1 | 38,201 | Jake Westbrook | Edinson Volquez | Jake Westbrook | Edinson Volquez | Mitchell Boggs | 114 | 83 | 31 |
| 2011-04-26 | @ HOU | 23 | L 5-6 | 12-11 | 2 | 25,526 | Jaime Garcia | Bud Norris | Brandon Lyon | Mitchell Boggs | | 119 | 89 | 30 |
| 2011-04-27 | @ HOU | 24 | W 6-5 | 13-11 | 1 | 27,857 | Kyle Lohse | J.A. Happ | Kyle Lohse | J.A. Happ | Eduardo Sanchez | 125 | 94 | 31 |
| 2011-04-28 | @ HOU | 25 | W 11-7 | 14-11 | 1 | 26,331 | Kyle McClellan | Nelson Figueroa | Kyle McClellan | Fernando Abad | Fernando Salas | 136 | 101 | 35 |
| 2011-04-29 | @ ATL | 26 | W 5-3 | 15-11 | 1 | 40,279 | Chris Carpenter | Tim Hudson | Eduardo Sanchez | Cory Gearrin | Trever Miller | 141 | 104 | 37 |
| 2011-04-30 | @ ATL | 27 | W 3-2 | 16-11 | 1 | 30,546 | Jake Westbrook | Brandon Beachy | Miguel Batista | Craig Kimbrel | Fernando Salas | 144 | 106 | 38 |
| 2011-05-01 | @ ATL | 28 | L 5-6 | 16-12 | 1 | 34,129 | Jaime Garcia | Derek Lowe | Jonny Venters | Ryan Franklin | | 149 | 112 | 37 |
| 2011-05-02 | vs FLO | 29 | L 5-6 | 16-13 | 1 | 32,635 | Kyle Lohse | Chris Volstad | Edward Mujica | Mitchell Boggs | Leo Nunez | 154 | 118 | 36 |
| 2011-05-03 | vs FLO | 30 | W 7-5 | 17-13 | 1 | 32,689 | Kyle McClellan | Anibal Sanchez | Fernando Salas | Ryan Webb | Eduardo Sanchez | 161 | 123 | 38 |
| 2011-05-04 | vs FLO | 31 | L 7-8 | 17-14 | 1 | 34,324 | Chris Carpenter | Javier Vazquez | Michael Dunn | Eduardo Sanchez | Leo Nunez | 168 | 131 | 37 |
| 2011-05-05 | vs FLO | 32 | W 6-3 | 18-14 | 1 | 38,509 | Jake Westbrook | Josh Johnson | Jason Motte | Josh Johnson | Eduardo Sanchez | 174 | 134 | 40 |
| 2011-05-06 | vs MIL | 33 | W 6-0 | 19-14 | 1 | 35,552 | Jaime Garcia | Randy Wolf | Jaime Garcia | Randy Wolf | | 180 | 134 | 46 |
| 2011-05-07 | vs MIL | 34 | L 0-4 | 19-15 | 1 | 40,229 | Kyle Lohse | Yovani Gallardo | Yovani Gallardo | Kyle Lohse | | 180 | 138 | 42 |
| 2011-05-08 | vs MIL | 35 | W 3-1 | 20-15 | 1 | 40,125 | Kyle McClellan | Chris Narveson | Kyle McClellan | Chris Narveson | Fernando Salas | 183 | 139 | 44 |
| 2011-05-10 | @ CHN | 36 | W 6-4 | 21-15 | 1 | 34,249 | Chris Carpenter | Carlos Zambrano | Chris Carpenter | Kerry Wood | Eduardo Sanchez | 189 | 143 | 46 |
| 2011-05-11 | @ CHN | 37 | L 4-11 | 21-16 | 1 | 34,439 | Jake Westbrook | Matt Garza | Matt Garza | Jake Westbrook | | 193 | 154 | 39 |
| 2011-05-12 | @ CHN | 38 | W 9-1 | 22-16 | 1 | 32,559 | Jaime Garcia | Casey Coleman | Jaime Garcia | Casey Coleman | | 202 | 155 | 47 |
| 2011-05-13 | @ CIN | 39 | L 5-6 | 22-17 | 1 | 32,972 | Kyle Lohse | Bronson Arroyo | Francisco Cordero | Jason Motte | | 207 | 161 | 46 |
| 2011-05-14 | @ CIN | 40 | L 3-7 | 22-18 | 2 | 41,307 | Kyle McClellan | Johnny Cueto | Johnny Cueto | Kyle McClellan | | 210 | 168 | 42 |
| 2011-05-15 | @ CIN | 41 | L 7-9 | 22-19 | 2 | 24,672 | Chris Carpenter | Travis Wood | Travis Wood | Chris Carpenter | Francisco Cordero | 217 | 177 | 40 |
| 2011-05-16 | vs PHI | 42 | W 3-1 | 23-19 | 2 | 34,884 | Jake Westbrook | Cliff Lee | Jake Westbrook | Cliff Lee | Fernando Salas | 220 | 178 | 42 |
| 2011-05-17 | vs PHI | 43 | W 2-1 | 24-19 | 2 | 34,567 | Jaime Garcia | Roy Oswalt | Fernando Salas | Danys Baez | | 222 | 179 | 43 |
| 2011-05-18 | vs HOU | 44 | W 5-1 | 25-19 | 2 | 35,298 | Kyle Lohse | Bud Norris | Kyle Lohse | Bud Norris | | 227 | 180 | 47 |
| 2011-05-19 | vs HOU | 45 | W 4-2 | 26-19 | 1 | 36,409 | Kyle McClellan | J.A. Happ | Kyle McClellan | J.A. Happ | Fernando Salas | 231 | 182 | 49 |
| 2011-05-20 | @ KCA | 46 | L 0-3 | 26-20 | 1 | 26,816 | Chris Carpenter | Jeff Francis | Jeff Francis | Chris Carpenter | Joakim Soria | 231 | 185 | 46 |
| 2011-05-21 | @ KCA | 47 | W 3-0 | 27-20 | 1 | 32,229 | Jake Westbrook | Nathan Adcock | Jake Westbrook | Tim Collins | Fernando Salas | 234 | 185 | 49 |
| 2011-05-22 | @ KCA | 48 | W 9-8 | 28-20 | 1 | 28,195 | Jaime Garcia | Sean O'Sullivan | Jason Motte | Louis Coleman | Fernando Salas | 243 | 193 | 50 |
| 2011-05-23 | @ SDN | 49 | W 3-1 | 29-20 | 1 | 16,513 | Kyle Lohse | Dustin Moseley | Kyle Lohse | Heath Bell | Fernando Salas | 246 | 194 | 52 |
| 2011-05-24 | @ SDN | 50 | W 3-2 | 30-20 | 1 | 19,426 | Kyle McClellan | Aaron Harang | Miguel Batista | Ernesto Frieri | Eduardo Sanchez | 249 | 196 | 53 |
| 2011-05-25 | @ SDN | 51 | L 1-3 | 30-21 | 1 | 23,088 | Chris Carpenter | Mat Latos | Mat Latos | Chris Carpenter | Heath Bell | 250 | 199 | 51 |
| 2011-05-27 | @ COL | 52 | W 10-3 | 31-21 | 1 | 31,285 | Jake Westbrook | Ubaldo Jimenez | Jake Westbrook | Ubaldo Jimenez | | 260 | 202 | 58 |
| 2011-05-28 | @ COL | 53 | L 4-15 | 31-22 | 1 | 38,149 | Jaime Garcia | Juan Nicasio | Juan Nicasio | Jaime Garcia | | 264 | 217 | 47 |
| 2011-05-29 | @ COL | 54 | W 4-3 | 32-22 | 1 | 40,598 | Kyle Lohse | Jhoulis Chacin | Kyle Lohse | Jhoulis Chacin | Fernando Salas | 268 | 220 | 48 |
| 2011-05-30 | vs SFN | 55 | L 3-7 | 32-23 | 1 | 40,849 | Kyle McClellan | Madison Bumgarner | Madison Bumgarner | Kyle McClellan | | 271 | 227 | 44 |
| 2011-05-31 | vs SFN | 56 | W 4-3 | 33-23 | 1 | 37,748 | Chris Carpenter | Ryan Vogelsong | Ryan Franklin | Javier Lopez | Fernando Salas | 275 | 230 | 45 |
| 2011-06-01 | vs SFN | 57 | L 5-7 | 33-24 | 1 | 35,775 | Jake Westbrook | Tim Lincecum | Sergio Romo | Ryan Franklin | Brian Wilson | 280 | 237 | 43 |
| 2011-06-02 | vs SFN | 58 | L 7-12 | 33-25 | 1 | 34,104 | Lance Lynn | Jonathan Sanchez | Jonathan Sanchez | Lance Lynn | Jeremy Affeldt | 287 | 249 | 38 |
| 2011-06-03 | vs CHN | 59 | W 6-1 | 34-25 | 1 | 40,419 | Jaime Garcia | Ryan Dempster | Jaime Garcia | Ryan Dempster | | 293 | 250 | 43 |
| 2011-06-04 | vs CHN | 60 | W 5-4 | 35-25 | 1 | 43,195 | Kyle Lohse | Randy Wells | Eduardo Sanchez | Jeff Samardzija | | 298 | 254 | 44 |
| 2011-06-05 | vs CHN | 61 | W 3-2 | 36-25 | 1 | 40,701 | Chris Carpenter | Carlos Zambrano | Fernando Salas | Rodrigo Lopez | | 301 | 256 | 45 |
| 2011-06-07 | @ HOU | 62 | W 7-4 | 37-25 | 1 | 23,277 | Jake Westbrook | Brett Myers | Jake Westbrook | Brett Myers | Fernando Salas | 308 | 260 | 48 |
| 2011-06-08 | @ HOU | 63 | L 1-4 | 37-26 | 1 | 22,107 | Jaime Garcia | Bud Norris | Bud Norris | Jaime Garcia | Mark Melancon | 309 | 264 | 45 |
| 2011-06-09 | @ HOU | 64 | W 9-2 | 38-26 | 1 | 24,482 | Lance Lynn | J.A. Happ | Lance Lynn | J.A. Happ | | 318 | 266 | 52 |
| 2011-06-10 | @ MIL | 65 | L 0-8 | 38-27 | 1 | 33,240 | Kyle Lohse | Chris Narveson | Chris Narveson | Kyle Lohse | | 318 | 274 | 44 |
| 2011-06-11 | @ MIL | 66 | L 3-5 | 38-28 | 1 | 41,930 | Chris Carpenter | Zack Greinke | Zack Greinke | Chris Carpenter | John Axford | 321 | 279 | 42 |
| 2011-06-12 | @ MIL | 67 | L 3-4 | 38-29 | 2 | 42,692 | Jake Westbrook | Shaun Marcum | Shaun Marcum | Jake Westbrook | John Axford | 324 | 283 | 41 |
| 2011-06-14 | @ WAS | 68 | L 6-8 | 38-30 | 2 | 26,739 | Jaime Garcia | Yuniesky Maya | Henry Rodriguez | Miguel Batista | Drew Storen | 330 | 291 | 39 |
| 2011-06-15 | @ WAS | 69 | L 0-10 | 38-31 | 2 | 27,130 | Kyle McClellan | Livan Hernandez | Livan Hernandez | Kyle McClellan | | 330 | 301 | 29 |
| 2011-06-16 | @ WAS | 70 | L 4-7 | 38-32 | 2 | 19,662 | Kyle Lohse | John Lannan | Sean Burnett | Fernando Salas | | 334 | 308 | 26 |
| 2011-06-17 | vs KCA | 71 | L 4-5 | 38-33 | 2 | 40,674 | Chris Carpenter | Felipe Paulino | Blake Wood | Chris Carpenter | Joakim Soria | 338 | 313 | 25 |
| 2011-06-18 | vs KCA | 72 | W 5-4 | 39-33 | 2 | 43,102 | Jake Westbrook | Vin Mazzaro | Jason Motte | Greg Holland | Fernando Salas | 343 | 317 | 26 |
| 2011-06-19 | vs KCA | 73 | W 5-4 | 40-33 | 2 | 41,660 | Jaime Garcia | Danny Duffy | Fernando Salas | Tim Collins | | 348 | 321 | 27 |
| 2011-06-21 | vs PHI | 74 | L 2-10 | 40-34 | 2 | 40,095 | Kyle McClellan | Roy Halladay | Michael Stutes | Trever Miller | | 350 | 331 | 19 |
| 2011-06-22 | vs PHI | 75 | L 0-4 | 40-35 | 2 | 36,520 | Kyle Lohse | Cliff Lee | Cliff Lee | Kyle Lohse | | 350 | 335 | 15 |
| 2011-06-23 | vs PHI | 76 | W 12-2 | 41-35 | 1 | 40,532 | Chris Carpenter | Roy Oswalt | Chris Carpenter | Roy Oswalt | | 362 | 337 | 25 |
| 2011-06-24 | vs TOR | 77 | L 4-5 | 41-36 | 2 | 37,724 | Jake Westbrook | Brandon Morrow | Jason Frasor | Fernando Salas | Frank Francisco | 366 | 342 | 24 |
| 2011-06-25 | vs TOR | 78 | L 3-6 | 41-37 | 2 | 40,289 | Jaime Garcia | Carlos Villanueva | Carlos Villanueva | Jaime Garcia | | 369 | 348 | 21 |
| 2011-06-26 | vs TOR | 79 | L 0-5 | 41-38 | 2 | 36,542 | Kyle McClellan | Ricky Romero | Ricky Romero | Kyle McClellan | | 369 | 353 | 16 |
| 2011-06-28 | @ BAL | 80 | W 6-2 | 42-38 | 2 | 20,556 | Kyle Lohse | Zachary Britton | Kyle Lohse | Zachary Britton | | 375 | 355 | 20 |
| 2011-06-29 | @ BAL | 81 | W 5-1 | 43-38 | 2 | 17,405 | Chris Carpenter | Chris Jakubauskas | Chris Carpenter | Chris Jakubauskas | | 380 | 356 | 24 |
| 2011-06-30 | @ BAL | 82 | W 9-6 | 44-38 | 2 | 28,340 | Jaime Garcia | Brian Matusz | Jaime Garcia | Brian Matusz | Fernando Salas | 389 | 362 | 27 |
| 2011-07-01 | @ TBA | 83 | W 5-3 | 45-38 | 1 | 19,934 | Jake Westbrook | Wade Davis | Jake Westbrook | Wade Davis | Fernando Salas | 394 | 365 | 29 |
| 2011-07-02 | @ TBA | 84 | L 1-5 | 45-39 | 2 | 23,897 | Kyle McClellan | Jeff Niemann | Jeff Niemann | Kyle McClellan | | 395 | 370 | 25 |
| 2011-07-03 | @ TBA | 85 | L 3-8 | 45-40 | 2 | 26,819 | Kyle Lohse | Jeremy Hellickson | Jeremy Hellickson | Kyle Lohse | Kyle Farnsworth | 398 | 378 | 20 |
| 2011-07-04 | vs CIN | 86 | W 1-0 | 46-40 | 1 | 40,551 | Chris Carpenter | Johnny Cueto | Chris Carpenter | Johnny Cueto | Fernando Salas | 399 | 378 | 21 |
| 2011-07-05 | vs CIN | 87 | W 8-1 | 47-40 | 1 | 36,090 | Jaime Garcia | Edinson Volquez | Jaime Garcia | Edinson Volquez | | 407 | 379 | 28 |
| 2011-07-06 | vs CIN | 88 | L 8-9 | 47-41 | 1 | 37,223 | Jake Westbrook | Bronson Arroyo | Jose Arredondo | Raul Valdes | Aroldis Chapman | 415 | 388 | 27 |
| 2011-07-07 | vs ARI | 89 | L 1-4 | 47-42 | 2 | 35,274 | Kyle McClellan | Joe Saunders | Joe Saunders | Kyle McClellan | David Hernandez | 416 | 392 | 24 |
| 2011-07-08 | vs ARI | 90 | L 6-7 | 47-43 | 3 | 37,160 | Kyle Lohse | Ian Kennedy | Ian Kennedy | Kyle Lohse | David Hernandez | 422 | 399 | 23 |
| 2011-07-09 | vs ARI | 91 | W 7-6 | 48-43 | 2 | 42,745 | Chris Carpenter | Daniel Hudson | Fernando Salas | Joe Paterson | | 429 | 405 | 24 |
| 2011-07-10 | vs ARI | 92 | W 4-2 | 49-43 | 2 | 35,299 | Jaime Garcia | Zach Duke | Jaime Garcia | Zach Duke | Fernando Salas | 433 | 407 | 26 |
| 2011-07-15 | @ CIN | 93 | L 5-6 | 49-44 | 2 | 41,238 | Jake Westbrook | Johnny Cueto | Logan Ondrusek | Fernando Salas | | 438 | 413 | 25 |
| 2011-07-16 | @ CIN | 94 | W 4-1 | 50-44 | 1 | 40,204 | Chris Carpenter | Bronson Arroyo | Chris Carpenter | Bronson Arroyo | Fernando Salas | 442 | 414 | 28 |
| 2011-07-17 | @ CIN | 95 | L 1-3 | 50-45 | 3 | 24,841 | Jaime Garcia | Homer Bailey | Homer Bailey | Jaime Garcia | Francisco Cordero | 443 | 417 | 26 |
| 2011-07-19 | @ NYN | 96 | L 2-4 | 50-46 | 3 | 35,448 | Kyle Lohse | Dillon Gee | Dillon Gee | Kyle Lohse | Jason Isringhausen | 445 | 421 | 24 |
| 2011-07-20 | @ NYN | 97 | L 5-6 | 50-47 | 3 | 30,770 | Kyle McClellan | R.A. Dickey | Jason Isringhausen | Fernando Salas | | 450 | 427 | 23 |
| 2011-07-21 | @ NYN | 98 | W 6-2 | 51-47 | 3 | 37,416 | Jake Westbrook | Jonathon Niese | Jake Westbrook | Jonathon Niese | | 456 | 429 | 27 |
| 2011-07-22 | @ PIT | 99 | W 6-4 | 52-47 | 3 | 38,490 | Chris Carpenter | Paul Maholm | Chris Carpenter | Paul Maholm | Fernando Salas | 462 | 433 | 29 |
| 2011-07-23 | @ PIT | 100 | W 9-1 | 53-47 | 1 | 39,102 | Jaime Garcia | Kevin Correia | Jaime Garcia | Kevin Correia | | 471 | 434 | 37 |
| 2011-07-24 | @ PIT | 101 | L 3-4 | 53-48 | 2 | 35,402 | Kyle Lohse | Charlie Morton | Joe Beimel | Jason Motte | | 474 | 438 | 36 |
| 2011-07-25 | vs HOU | 102 | W 10-5 | 54-48 | 2 | 38,074 | Kyle McClellan | J.A. Happ | Kyle McClellan | J.A. Happ | Mitchell Boggs | 484 | 443 | 41 |
| 2011-07-26 | vs HOU | 103 | W 3-1 | 55-48 | 1 | 35,588 | Jake Westbrook | Brett Myers | Jake Westbrook | Brett Myers | Fernando Salas | 487 | 444 | 43 |
| 2011-07-27 | vs HOU | 104 | L 2-4 | 55-49 | 2 | 35,679 | Chris Carpenter | Bud Norris | Fernando Rodriguez | Mitchell Boggs | Mark Melancon | 489 | 448 | 41 |
| 2011-07-28 | vs HOU | 105 | L 3-5 | 55-50 | 3 | 38,794 | Jaime Garcia | Wandy Rodriguez | Wandy Rodriguez | Jaime Garcia | Mark Melancon | 492 | 453 | 39 |
| 2011-07-29 | vs CHN | 106 | W 9-2 | 56-50 | 2 | 42,042 | Edwin Jackson | Matt Garza | Edwin Jackson | Matt Garza | | 501 | 455 | 46 |
| 2011-07-30 | vs CHN | 107 | W 13-5 | 57-50 | 2 | 43,784 | Kyle Lohse | Rodrigo Lopez | Kyle Lohse | Rodrigo Lopez | | 514 | 460 | 54 |
| 2011-07-31 | vs CHN | 108 | L 3-6 | 57-51 | 2 | 43,960 | Jake Westbrook | Ryan Dempster | Ryan Dempster | Jake Westbrook | Carlos Marmol | 517 | 466 | 51 |
| 2011-08-01 | @ MIL | 109 | L 2-6 | 57-52 | 2 | 41,619 | Chris Carpenter | Zack Greinke | Zack Greinke | Chris Carpenter | | 519 | 472 | 47 |
| 2011-08-02 | @ MIL | 110 | W 8-7 | 58-52 | 2 | 39,393 | Jaime Garcia | Shaun Marcum | Kyle McClellan | Marco Estrada | Octavio Dotel | 527 | 479 | 48 |
| 2011-08-03 | @ MIL | 111 | L 5-10 | 58-53 | 2 | 41,906 | Edwin Jackson | Randy Wolf | Randy Wolf | Edwin Jackson | | 532 | 489 | 43 |
| 2011-08-04 | @ FLO | 112 | W 7-4 | 59-53 | 2 | 20,011 | Kyle Lohse | Clay Hensley | Kyle McClellan | Clay Hensley | Fernando Salas | 539 | 493 | 46 |
| 2011-08-05 | @ FLO | 113 | W 3-2 | 60-53 | 2 | 19,303 | Jake Westbrook | Anibal Sanchez | Mitchell Boggs | Anibal Sanchez | Lance Lynn | 542 | 495 | 47 |
| 2011-08-06 | @ FLO | 114 | W 2-1 | 61-53 | 2 | 23,922 | Chris Carpenter | Ricky Nolasco | Chris Carpenter | Ricky Nolasco | Fernando Salas | 544 | 496 | 48 |
| 2011-08-07 | @ FLO | 115 | W 8-4 | 62-53 | 2 | 20,011 | Jaime Garcia | Javier Vazquez | Mitchell Boggs | Michael Dunn | | 552 | 500 | 52 |
| 2011-08-09 | vs MIL | 116 | L 3-5 | 62-54 | 2 | 40,626 | Edwin Jackson | Shaun Marcum | LaTroy Hawkins | Octavio Dotel | John Axford | 555 | 505 | 50 |
| 2011-08-10 | vs MIL | 117 | L 1-5 | 62-55 | 2 | 38,397 | Jake Westbrook | Randy Wolf | Randy Wolf | Jake Westbrook | | 556 | 510 | 46 |
| 2011-08-11 | vs MIL | 118 | W 5-2 | 63-55 | 2 | 38,302 | Chris Carpenter | Yovani Gallardo | Chris Carpenter | Yovani Gallardo | Fernando Salas | 561 | 512 | 49 |
| 2011-08-12 | vs COL | 119 | W 6-1 | 64-55 | 2 | 36,181 | Kyle Lohse | Aaron Cook | Kyle Lohse | Aaron Cook | | 567 | 513 | 54 |
| 2011-08-13 | vs COL | 120 | L 1-6 | 64-56 | 2 | 40,172 | Jaime Garcia | Jason Hammel | Jason Hammel | Jaime Garcia | | 568 | 519 | 49 |
| 2011-08-14 | vs COL | 121 | W 6-2 | 65-56 | 2 | 38,748 | Edwin Jackson | Esmil Rogers | Edwin Jackson | Esmil Rogers | | 574 | 521 | 53 |
| 2011-08-15 | @ PIT | 122 | L 2-6 | 65-57 | 2 | 19,766 | Jake Westbrook | James McDonald | James McDonald | Jake Westbrook | | 576 | 527 | 49 |
| 2011-08-16 | @ PIT | 123 | L 4-5 | 65-58 | 2 | 20,943 | Chris Carpenter | Jeff Karstens | Chris Resop | Arthur Rhodes | | 580 | 532 | 48 |
| 2011-08-17 | @ PIT | 124 | W 7-2 | 66-58 | 2 | 22,296 | Kyle Lohse | Paul Maholm | Kyle Lohse | Paul Maholm | | 587 | 534 | 53 |
| 2011-08-19 | @ CHN | 125 | L 4-5 | 66-59 | 2 | 42,343 | Jaime Garcia | Randy Wells | Sean Marshall | Octavio Dotel | | 591 | 539 | 52 |
| 2011-08-20 | @ CHN | 126 | L 0-3 | 66-60 | 2 | 42,374 | Edwin Jackson | Matt Garza | Matt Garza | Edwin Jackson | Carlos Marmol | 591 | 542 | 49 |
| 2011-08-21 | @ CHN | 127 | W 6-2 | 67-60 | 2 | 39,420 | Jake Westbrook | Rodrigo Lopez | Jake Westbrook | Rodrigo Lopez | | 597 | 544 | 53 |
| 2011-08-22 | vs LAN | 128 | L 1-2 | 67-61 | 3 | 35,198 | Chris Carpenter | Nathan Eovaldi | Matt Guerrier | Fernando Salas | Javy Guerra | 598 | 546 | 52 |
| 2011-08-23 | vs LAN | 129 | L 2-13 | 67-62 | 2 | 37,062 | Kyle Lohse | Clayton Kershaw | Clayton Kershaw | Kyle Lohse | | 600 | 559 | 41 |
| 2011-08-24 | vs LAN | 130 | L 4-9 | 67-63 | 2 | 32,959 | Jaime Garcia | Hiroki Kuroda | Hiroki Kuroda | Jaime Garcia | | 604 | 568 | 36 |
| 2011-08-25 | vs PIT | 131 | W 8-4 | 68-63 | 2 | 36,503 | Edwin Jackson | Charlie Morton | Edwin Jackson | Charlie Morton | | 612 | 572 | 40 |
| 2011-08-26 | vs PIT | 132 | W 5-4 | 69-63 | 2 | 40,480 | Jake Westbrook | James McDonald | Kyle McClellan | Jose Veras | | 617 | 576 | 41 |
| 2011-08-27 | vs PIT | 133 | L 0-7 | 69-64 | 2 | 35,812 | Chris Carpenter | Brad Lincoln | Brad Lincoln | Chris Carpenter | | 617 | 583 | 34 |
| 2011-08-28 | vs PIT | 134 | W 7-4 | 70-64 | 2 | 38,429 | Kyle Lohse | Jeff Karstens | Kyle Lohse | Jeff Karstens | Jason Motte | 624 | 587 | 37 |
| 2011-08-30 | @ MIL | 135 | W 2-1 | 71-64 | 2 | 42,384 | Edwin Jackson | Shaun Marcum | Edwin Jackson | Shaun Marcum | Fernando Salas | 626 | 588 | 38 |
| 2011-08-31 | @ MIL | 136 | W 8-3 | 72-64 | 2 | 38,073 | Jake Westbrook | Randy Wolf | Jake Westbrook | Randy Wolf | | 634 | 591 | 43 |
| 2011-09-01 | @ MIL | 137 | W 8-4 | 73-64 | 2 | 34,080 | Brandon Dickson | Yovani Gallardo | Octavio Dotel | Yovani Gallardo | | 642 | 595 | 47 |
| 2011-09-02 | vs CIN | 138 | L 8-11 | 73-65 | 2 | 36,970 | Chris Carpenter | Johnny Cueto | Jose Arredondo | Marc Rzepczynski | | 650 | 606 | 44 |
| 2011-09-03 | vs CIN | 139 | W 6-4 | 74-65 | 2 | 41,839 | Jaime Garcia | Homer Bailey | Jaime Garcia | Homer Bailey | Jason Motte | 656 | 610 | 46 |
| 2011-09-04 | vs CIN | 140 | L 2-3 | 74-66 | 2 | 41,647 | Edwin Jackson | Bronson Arroyo | Bill Bray | Fernando Salas | Francisco Cordero | 658 | 613 | 45 |
| 2011-09-05 | vs MIL | 141 | L 1-4 | 74-67 | 2 | 42,043 | Jake Westbrook | Randy Wolf | Randy Wolf | Jake Westbrook | John Axford | 659 | 617 | 42 |
| 2011-09-06 | vs MIL | 142 | W 4-2 | 75-67 | 2 | 35,397 | Kyle Lohse | Yovani Gallardo | Kyle Lohse | Yovani Gallardo | Jason Motte | 663 | 619 | 44 |
| 2011-09-07 | vs MIL | 143 | W 2-0 | 76-67 | 2 | 38,891 | Chris Carpenter | Zack Greinke | Chris Carpenter | Zack Greinke | | 665 | 619 | 46 |
| 2011-09-09 | vs ATL | 144 | W 4-3 | 77-67 | 2 | 37,129 | Edwin Jackson | Randall Delgado | Jason Motte | Scott Linebrink | | 669 | 622 | 47 |
| 2011-09-10 | vs ATL | 145 | W 4-3 | 78-67 | 2 | 40,689 | Jaime Garcia | Derek Lowe | Jaime Garcia | Derek Lowe | Jason Motte | 673 | 625 | 48 |
| 2011-09-11 | vs ATL | 146 | W 6-3 | 79-67 | 2 | 39,710 | Jake Westbrook | Tim Hudson | Jake Westbrook | Tim Hudson | Jason Motte | 679 | 628 | 51 |
| 2011-09-12 | @ PIT | 147 | L 5-6 | 79-68 | 2 | 13,278 | Kyle Lohse | Brad Lincoln | Jason Grilli | Marc Rzepczynski | Joel Hanrahan | 684 | 634 | 50 |
| 2011-09-13 | @ PIT | 148 | W 6-4 | 80-68 | 2 | 16,544 | Chris Carpenter | Jeff Karstens | Kyle McClellan | Joel Hanrahan | Jason Motte | 690 | 638 | 52 |
| 2011-09-14 | @ PIT | 149 | W 3-2 | 81-68 | 2 | 12,520 | Edwin Jackson | Charlie Morton | Edwin Jackson | Charlie Morton | Jason Motte | 693 | 640 | 53 |
| 2011-09-16 | @ PHI | 150 | W 4-2 | 82-68 | 2 | 45,572 | Jaime Garcia | Vance Worley | Kyle McClellan | Michael Schwimer | Fernando Salas | 697 | 642 | 55 |
| 2011-09-17 | @ PHI | 151 | L 2-9 | 82-69 | 2 | 45,470 | Jake Westbrook | Roy Oswalt | Roy Oswalt | Jake Westbrook | | 699 | 651 | 48 |
| 2011-09-18 | @ PHI | 152 | W 5-0 | 83-69 | 2 | 45,063 | Chris Carpenter | Cole Hamels | Chris Carpenter | Cole Hamels | | 704 | 651 | 53 |
| 2011-09-19 | @ PHI | 153 | W 4-3 | 84-69 | 2 | 45,048 | Kyle Lohse | Roy Halladay | Kyle Lohse | Roy Halladay | Octavio Dotel | 708 | 654 | 54 |
| 2011-09-20 | vs NYN | 154 | W 11-6 | 85-69 | 2 | 37,746 | Edwin Jackson | Mike Pelfrey | Octavio Dotel | Josh Stinson | | 719 | 660 | 59 |
| 2011-09-21 | vs NYN | 155 | W 6-5 | 86-69 | 2 | 40,658 | Jaime Garcia | Chris Schwinden | Jaime Garcia | Danny Herrera | Jason Motte | 725 | 665 | 60 |
| 2011-09-22 | vs NYN | 156 | L 6-8 | 86-70 | 2 | 35,992 | Jake Westbrook | Chris Capuano | Manny Acosta | Marc Rzepczynski | Bobby Parnell | 731 | 673 | 58 |
| 2011-09-23 | vs CHN | 157 | L 1-5 | 86-71 | 2 | 40,355 | Chris Carpenter | Ryan Dempster | Jeff Samardzija | Kyle McClellan | | 732 | 678 | 54 |
| 2011-09-24 | vs CHN | 158 | W 2-1 | 87-71 | 2 | 42,571 | Kyle Lohse | Rodrigo Lopez | Jason Motte | Carlos Marmol | | 734 | 679 | 55 |
| 2011-09-25 | vs CHN | 159 | W 3-2 | 88-71 | 2 | 41,469 | Edwin Jackson | Randy Wells | Octavio Dotel | Randy Wells | Jason Motte | 737 | 681 | 56 |
| 2011-09-26 | @ HOU | 160 | L 4-5 | 88-72 | 2 | 20,017 | Jaime Garcia | Wandy Rodriguez | Mark Melancon | Octavio Dotel | | 741 | 686 | 55 |
| 2011-09-27 | @ HOU | 161 | W 13-6 | 89-72 | 2 | 22,021 | Jake Westbrook | Henry Sosa | Eduardo Sanchez | Enerio Del Rosario | | 754 | 692 | 62 |
| 2011-09-28 | @ HOU | 162 | W 8-0 | 90-72 | 2 | 24,358 | Chris Carpenter | Brett Myers | Chris Carpenter | Brett Myers | | 762 | 692 | 70 |