| Logan Ondrusek | 2010-04-05 | 2010 | L 11-6 vs CIN | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| Juan Francisco | 2010-04-10 | 2010 | L 4-3 vs CIN | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 17 | 10 | 1 | 8 | 0 | 4 strikeouts |
| Mike Leake | 2010-04-11 | 2010 | W 3-1 vs CIN | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 1st career game, 1st career hit |
| Scott Rolen | 2010-04-12 | 2010 | W 6-5 @ FLO | 5 | 2 | 3 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1754 | 1817 | 286 | 1133 | 114 | 2 home runs |
| Brandon Phillips | 2010-04-13 | 2010 | W 10-8 @ FLO | 6 | 2 | 4 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 744 | 740 | 95 | 389 | 110 | 4 hits |
| Jay Bruce | 2010-04-18 | 2010 | L 5-3 @ PIT | 4 | 2 | 2 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 222 | 190 | 45 | 114 | 9 | 2 home runs |
| Chris Dickerson | 2010-04-23 | 2010 | L 10-4 vs CIN | 5 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 144 | 110 | 8 | 30 | 18 | 4 strikeouts |
| Chris Heisey | 2010-05-03 | 2010 | W 3-2 vs CIN | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| Ryan Hanigan | 2010-05-08 | 2010 | W 14-2 vs CIN | 4 | 1 | 3 | 1 | 0 | 1 | 5 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 143 | 110 | 7 | 37 | 0 | 5 RBis |
| Chris Heisey | 2010-05-11 | 2010 | W 9-0 @ PIT | 4 | 2 | 3 | 0 | 0 | 1 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 2 | 0 | 1st career hit, 1st career home run, 1st career RBI |
| Jay Bruce | 2010-05-22 | 2010 | W 6-4 @ CLE | 4 | 1 | 4 | 1 | 0 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 252 | 223 | 47 | 128 | 12 | 4 hits |
| Orlando Cabrera | 2010-05-23 | 2010 | L 4-3 @ CLE | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1773 | 1863 | 117 | 781 | 200 | 200th career stolen base |
| Scott Rolen | 2010-05-23 | 2010 | L 4-3 @ CLE | 3 | 2 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1787 | 1849 | 293 | 1156 | 114 | 2 home runs |
| Enerio Del Rosario | 2010-05-24 | 2010 | W 7-5 vs CIN | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| Brandon Phillips | 2010-05-25 | 2010 | L 2-1 vs CIN | 4 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 782 | 779 | 100 | 397 | 113 | 100th career home run |
| Jonny Gomes | 2010-05-28 | 2010 | W 15-6 vs CIN | 4 | 2 | 4 | 0 | 1 | 1 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 555 | 415 | 93 | 267 | 33 | 4 hits |
| Sam LeCure | 2010-05-28 | 2010 | W 15-6 vs CIN | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| Jay Bruce | 2010-05-29 | 2010 | W 12-2 vs CIN | 5 | 2 | 3 | 1 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 259 | 230 | 50 | 134 | 12 | 2 home runs |
| Ramon Hernandez | 2010-05-29 | 2010 | W 12-2 vs CIN | 4 | 2 | 4 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1300 | 1149 | 144 | 651 | 8 | 2 home runs, 4 hits |
| Scott Rolen | 2010-06-01 | 2010 | W 9-8 @ SLN | 5 | 2 | 3 | 1 | 0 | 2 | 4 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1796 | 1859 | 296 | 1165 | 114 | 2 home runs |
| Joey Votto | 2010-06-01 | 2010 | W 9-8 @ SLN | 5 | 3 | 4 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 352 | 391 | 64 | 219 | 18 | 4 hits |
| Sam LeCure | 2010-06-08 | 2010 | L 3-0 vs CIN | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 1st career hit |
| Orlando Cabrera | 2010-06-09 | 2010 | W 6-3 vs CIN | 5 | 3 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1789 | 1881 | 117 | 788 | 203 | 3 Doubles, 4 hits |
| Brandon Phillips | 2010-06-10 | 2010 | W 7-6 vs CIN | 5 | 2 | 4 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 797 | 805 | 101 | 405 | 117 | 4 hits |
| Scott Rolen | 2010-06-11 | 2010 | L 6-5 vs CIN | 6 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1805 | 1873 | 297 | 1173 | 114 | 4 hits |
| Jonny Gomes | 2010-06-12 | 2010 | W 11-5 vs CIN | 3 | 2 | 2 | 0 | 0 | 2 | 6 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 569 | 427 | 95 | 282 | 33 | 2 home runs, 6 RBis, 2 hit by pitches |
| Joey Votto | 2010-06-13 | 2010 | L 7-3 vs CIN | 4 | 2 | 2 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 363 | 400 | 66 | 226 | 19 | 2 home runs |
| Jordan Smith | 2010-06-15 | 2010 | L 12-0 vs CIN | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| Scott Rolen | 2010-06-28 | 2010 | W 7-3 vs CIN | 2 | 1 | 1 | 0 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1818 | 1885 | 300 | 1182 | 114 | 300th career home run |
| Travis Wood | 2010-07-01 | 2010 | W 3-2 @ CHN | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1st career game, 1st career hit |
| Paul Janish | 2010-07-04 | 2010 | W 14-3 @ CHN | 4 | 3 | 4 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 156 | 83 | 4 | 31 | 2 | 4 hits |
| Drew Stubbs | 2010-07-04 | 2010 | W 14-3 @ CHN | 5 | 3 | 3 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 120 | 113 | 19 | 58 | 26 | 3 home runs, 5 RBis |
| Joey Votto | 2010-07-05 | 2010 | W 8-6 @ NYN | 4 | 3 | 3 | 1 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 383 | 426 | 74 | 244 | 19 | 2 home runs |
| Travis Wood | 2010-07-05 | 2010 | W 8-6 @ NYN | 3 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 1 | 0 | 1st career RBI |
| Mike Leake | 2010-07-09 | 2010 | L 9-7 @ PHI | 4 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 16 | 14 | 0 | 1 | 0 | 1st career RBI |
| Drew Stubbs | 2010-07-17 | 2010 | W 8-1 vs CIN | 4 | 2 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 129 | 120 | 21 | 63 | 27 | 2 home runs |
| Brandon Phillips | 2010-07-27 | 2010 | W 12-4 @ MIL | 6 | 2 | 4 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 836 | 850 | 107 | 418 | 120 | 4 hits |
| Scott Rolen | 2010-07-27 | 2010 | W 12-4 @ MIL | 4 | 1 | 4 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1830 | 1896 | 300 | 1189 | 115 | 4 hits |
| Joey Votto | 2010-07-27 | 2010 | W 12-4 @ MIL | 6 | 3 | 4 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 400 | 446 | 78 | 253 | 20 | 4 hits |
| Jonny Gomes | 2010-08-08 | 2010 | W 11-4 @ CHN | 1 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 616 | 468 | 99 | 301 | 35 | 4 runs scored, 4 walks |
| Ryan Hanigan | 2010-08-08 | 2010 | W 11-4 @ CHN | 3 | 1 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 169 | 129 | 8 | 51 | 0 | 2 sacrifice flies |
| Chris Heisey | 2010-08-08 | 2010 | W 11-4 @ CHN | 3 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 62 | 31 | 7 | 13 | 0 | 2 hit by pitches |
| Joey Votto | 2010-08-08 | 2010 | W 11-4 @ CHN | 5 | 4 | 2 | 1 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 409 | 457 | 81 | 260 | 20 | 4 runs scored |
| Jim Edmonds | 2010-08-13 | 2010 | W 7-2 vs CIN | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2000 | 1943 | 390 | 1196 | 66 | 2000th career game |
| Jay Bruce | 2010-08-17 | 2010 | W 6-2 @ ARI | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 327 | 290 | 54 | 156 | 12 | Grounded into 3 Double Plays |
| Brandon Phillips | 2010-08-17 | 2010 | W 6-2 @ ARI | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 852 | 867 | 108 | 427 | 122 | 2 hit by pitches |
| Jay Bruce | 2010-08-18 | 2010 | W 11-7 @ ARI | 5 | 3 | 4 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 328 | 294 | 55 | 158 | 12 | 4 hits |
| Brandon Phillips | 2010-08-22 | 2010 | W 5-2 @ LAN | 5 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 857 | 878 | 108 | 431 | 122 | 4 hits |
| Brandon Phillips | 2010-08-24 | 2010 | L 16-5 @ SFN | 5 | 2 | 3 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 859 | 881 | 110 | 433 | 122 | 2 home runs |
| Chris Valaika | 2010-08-24 | 2010 | L 16-5 @ SFN | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1st career game, 1st career hit |
| Jonny Gomes | 2010-08-25 | 2010 | W 12-11 @ SFN | 5 | 2 | 2 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 628 | 474 | 100 | 303 | 35 | 100th career home run |
| Joey Votto | 2010-08-25 | 2010 | W 12-11 @ SFN | 7 | 2 | 4 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 422 | 477 | 84 | 275 | 23 | 2 home runs, 4 hits |
| Jay Bruce | 2010-08-27 | 2010 | W 7-1 vs CIN | 3 | 3 | 3 | 0 | 0 | 3 | 5 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 336 | 302 | 59 | 165 | 12 | 3 home runs, 5 RBis |
| Chris Valaika | 2010-08-27 | 2010 | W 7-1 vs CIN | 4 | 2 | 2 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 1 | 0 | 1st career home run, 1st career RBI |
| Aroldis Chapman | 2010-08-31 | 2010 | W 8-4 vs CIN | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| Chris Valaika | 2010-08-31 | 2010 | W 8-4 vs CIN | 5 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 7 | 9 | 1 | 2 | 0 | 4 strikeouts |
| Yonder Alonso | 2010-09-01 | 2010 | W 6-1 vs CIN | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| Yonder Alonso | 2010-09-04 | 2010 | W 6-1 @ SLN | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 1st career hit |
| Travis Wood | 2010-09-04 | 2010 | W 6-1 @ SLN | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 12 | 4 | 1 | 2 | 0 | 1st career home run |
| Joey Votto | 2010-09-10 | 2010 | W 4-3 vs CIN | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 0 | 436 | 490 | 85 | 285 | 25 | 2 hit by pitches |
| Jay Bruce | 2010-09-13 | 2010 | W 7-2 vs CIN | 4 | 2 | 3 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 340 | 310 | 63 | 172 | 12 | 2 home runs |
| Orlando Cabrera | 2010-09-15 | 2010 | W 7-5 vs CIN | 4 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1842 | 1940 | 118 | 801 | 206 | 3 Doubles |
| Yonder Alonso | 2010-09-18 | 2010 | W 11-1 @ HOU | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13 | 4 | 0 | 2 | 0 | 1st career RBI |
| Chris Heisey | 2010-09-29 | 2010 | L 2-0 vs CIN | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 93 | 50 | 8 | 21 | 1 | 1st career stolen base |
| Jay Bruce | 2010-10-01 | 2010 | L 4-3 vs CIN | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 355 | 321 | 65 | 176 | 12 | 4 strikeouts |
| Jonny Gomes | 2010-10-01 | 2010 | L 4-3 vs CIN | 5 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 659 | 506 | 104 | 320 | 37 | 4 strikeouts |
| Jay Bruce | 2010-10-02 | 2010 | W 7-4 vs CIN | 3 | 2 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 356 | 323 | 67 | 179 | 12 | 2 home runs |