| Central | W | L | Pct | GB |
| Cincinnati | 91 | 71 | .562 | -- |
| St. Louis | 86 | 76 | .531 | 5.0 |
| Milwaukee | 77 | 85 | .475 | 14.0 |
| Houston | 76 | 86 | .469 | 15.0 |
| Chi Cubs | 75 | 87 | .463 | 16.0 |
| Pittsburgh | 57 | 105 | .352 | 34.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2010-04-05 | Carlos Zambrano | R | 29 | L 5-16 | @ ATL | 1 | 239 | L | 1.1 | 6 | 8 | 8 | 2 | 2 | 1 | 47 | 21 | 26 | 55% | 0-1 | 72.00 | 8.00 |
| 2010-04-07 | Ryan Dempster | R | 33 | L 2-3 | @ ATL | 1 | 227 | - | 6.0 | 3 | 1 | 1 | 0 | 2 | 9 | 95 | 38 | 57 | 60% | 0-0 | 1.50 | 0.83 |
| 2010-04-08 | Randy Wells | R | 28 | W 2-0 | @ ATL | 1 | 28 | W | 6.0 | 6 | 0 | 0 | 0 | 2 | 1 | 97 | 39 | 58 | 60% | 1-0 | 0.00 | 1.33 |
| 2010-04-09 | Carlos Silva | R | 31 | L 4-5 | @ CIN | 1 | 160 | - | 6.0 | 3 | 1 | 1 | 0 | 0 | 3 | 71 | 23 | 48 | 68% | 0-0 | 1.50 | 0.50 |
| 2010-04-10 | Carlos Zambrano | R | 29 | W 4-3 | @ CIN | 2 | 240 | W | 7.0 | 6 | 3 | 3 | 1 | 2 | 9 | 114 | 48 | 66 | 58% | 1-1 | 12.38 | 2.00 |
| 2010-04-11 | Tom Gorzelanny | L | 28 | L 1-3 | @ CIN | 1 | 73 | - | 6.1 | 4 | 1 | 0 | 0 | 2 | 7 | 101 | 38 | 63 | 62% | 0-0 | 0.00 | 1.00 |
| 2010-04-12 | Ryan Dempster | R | 33 | L 9-5 | vs MIL | 2 | 228 | W | 6.1 | 7 | 5 | 5 | 1 | 4 | 5 | 112 | 51 | 61 | 54% | 1-0 | 4.50 | 1.33 |
| 2010-04-14 | Randy Wells | R | 28 | L 7-6 | vs MIL | 2 | 29 | - | 6.1 | 10 | 4 | 4 | 0 | 1 | 7 | 102 | 34 | 68 | 67% | 1-0 | 3.00 | 1.58 |
| 2010-04-15 | Carlos Zambrano | R | 29 | W 6-8 | vs MIL | 3 | 241 | - | 5.0 | 8 | 4 | 3 | 1 | 3 | 7 | 120 | 46 | 74 | 62% | 1-1 | 9.69 | 2.08 |
| 2010-04-16 | Carlos Silva | R | 31 | L 7-2 | vs HOU | 2 | 161 | W | 7.0 | 5 | 2 | 0 | 0 | 0 | 5 | 90 | 26 | 64 | 71% | 1-0 | 0.69 | 0.62 |
| 2010-04-17 | Tom Gorzelanny | L | 28 | W 3-4 | vs HOU | 2 | 74 | L | 3.0 | 3 | 2 | 2 | 0 | 1 | 0 | 40 | 17 | 23 | 58% | 0-1 | 2.00 | 1.11 |
| 2010-04-18 | Ryan Dempster | R | 33 | W 2-3 | vs HOU | 3 | 229 | - | 7.2 | 4 | 1 | 1 | 0 | 2 | 8 | 120 | 45 | 75 | 63% | 1-0 | 3.15 | 1.10 |
| 2010-04-19 | Randy Wells | R | 28 | L 1-6 | @ NYN | 3 | 30 | - | 6.0 | 6 | 1 | 1 | 0 | 2 | 5 | 93 | 33 | 60 | 65% | 1-0 | 2.50 | 1.50 |
| 2010-04-20 | Carlos Zambrano | R | 29 | L 0-4 | @ NYN | 4 | 242 | L | 6.0 | 6 | 2 | 2 | 0 | 3 | 9 | 116 | 51 | 65 | 56% | 1-2 | 7.58 | 1.89 |
| 2010-04-21 | Carlos Silva | R | 31 | W 9-3 | @ NYN | 3 | 162 | W | 6.0 | 2 | 1 | 1 | 1 | 2 | 4 | 87 | 29 | 58 | 67% | 2-0 | 0.95 | 0.63 |
| 2010-04-22 | Tom Gorzelanny | L | 28 | L 2-5 | @ NYN | 3 | 75 | L | 5.2 | 4 | 4 | 2 | 0 | 2 | 7 | 103 | 38 | 65 | 63% | 0-2 | 2.40 | 1.07 |
| 2010-04-23 | Ryan Dempster | R | 33 | W 8-1 | @ MIL | 4 | 230 | W | 7.2 | 7 | 1 | 1 | 0 | 1 | 4 | 113 | 44 | 69 | 61% | 2-0 | 2.57 | 1.07 |
| 2010-04-24 | Ted Lilly | L | 34 | W 5-1 | @ MIL | 1 | 256 | W | 6.0 | 3 | 0 | 0 | 0 | 2 | 4 | 78 | 28 | 50 | 64% | 1-0 | 0.00 | 0.83 |
| 2010-04-25 | Randy Wells | R | 28 | W 12-2 | @ MIL | 4 | 31 | W | 7.0 | 7 | 2 | 2 | 0 | 0 | 6 | 93 | 31 | 62 | 67% | 2-0 | 2.52 | 1.36 |
| 2010-04-26 | Carlos Silva | R | 31 | L 4-3 | vs WAS | 4 | 163 | - | 7.0 | 7 | 3 | 3 | 0 | 1 | 3 | 89 | 28 | 61 | 69% | 2-0 | 1.73 | 0.77 |
| 2010-04-27 | Tom Gorzelanny | L | 28 | W 1-3 | vs WAS | 4 | 76 | L | 7.0 | 5 | 2 | 2 | 0 | 2 | 3 | 96 | 40 | 56 | 58% | 0-3 | 2.45 | 1.05 |
| 2010-04-28 | Ryan Dempster | R | 33 | W 2-3 | vs WAS | 5 | 231 | L | 8.0 | 4 | 3 | 3 | 2 | 1 | 6 | 98 | 36 | 62 | 63% | 2-1 | 2.75 | 0.97 |
| 2010-04-29 | Ted Lilly | L | 34 | W 5-13 | vs ARI | 2 | 257 | L | 5.0 | 7 | 6 | 6 | 3 | 2 | 6 | 97 | 40 | 57 | 59% | 1-1 | 4.91 | 1.27 |
| 2010-04-30 | Randy Wells | R | 28 | L 11-5 | vs ARI | 5 | 32 | W | 6.0 | 8 | 5 | 5 | 1 | 0 | 8 | 94 | 29 | 65 | 69% | 3-0 | 3.48 | 1.35 |
| 2010-05-01 | Carlos Silva | R | 31 | L 7-5 | vs ARI | 5 | 164 | - | 5.0 | 8 | 5 | 5 | 3 | 3 | 6 | 96 | 39 | 57 | 59% | 2-0 | 2.90 | 1.00 |
| 2010-05-02 | Tom Gorzelanny | L | 28 | L 10-5 | vs ARI | 5 | 77 | W | 7.0 | 6 | 2 | 2 | 1 | 3 | 10 | 108 | 47 | 61 | 56% | 1-3 | 2.48 | 1.10 |
| 2010-05-04 | Ryan Dempster | R | 33 | L 2-3 | @ PIT | 6 | 232 | L | 7.0 | 8 | 3 | 3 | 2 | 1 | 7 | 105 | 34 | 71 | 68% | 2-2 | 2.93 | 1.02 |
| 2010-05-05 | Ted Lilly | L | 34 | L 2-4 | @ PIT | 3 | 258 | L | 6.0 | 9 | 4 | 4 | 1 | 0 | 2 | 73 | 17 | 56 | 77% | 1-2 | 5.29 | 1.35 |
| 2010-05-06 | Randy Wells | R | 28 | L 1-11 | @ PIT | 6 | 33 | L | 2.0 | 5 | 7 | 6 | 0 | 3 | 1 | 47 | 20 | 27 | 57% | 3-1 | 4.91 | 1.52 |
| 2010-05-07 | Carlos Silva | R | 31 | W 14-7 | @ CIN | 6 | 165 | W | 5.0 | 10 | 4 | 4 | 1 | 1 | 3 | 99 | 34 | 65 | 66% | 3-0 | 3.50 | 1.17 |
| 2010-05-08 | Tom Gorzelanny | L | 28 | L 2-14 | @ CIN | 6 | 78 | L | 6.0 | 9 | 3 | 3 | 1 | 1 | 9 | 99 | 36 | 63 | 64% | 1-4 | 2.83 | 1.20 |
| 2010-05-09 | Ryan Dempster | R | 33 | L 3-5 | @ CIN | 7 | 233 | L | 7.0 | 6 | 5 | 5 | 1 | 3 | 7 | 112 | 41 | 71 | 63% | 2-3 | 3.42 | 1.06 |
| 2010-05-10 | Ted Lilly | L | 34 | W 2-4 | vs FLO | 4 | 259 | L | 7.0 | 5 | 4 | 3 | 1 | 0 | 1 | 90 | 22 | 68 | 76% | 1-3 | 4.88 | 1.17 |
| 2010-05-11 | Randy Wells | R | 28 | W 2-3 | vs FLO | 7 | 34 | L | 8.0 | 4 | 3 | 3 | 2 | 1 | 8 | 106 | 37 | 69 | 65% | 3-2 | 4.61 | 1.34 |
| 2010-05-12 | Carlos Silva | R | 31 | L 4-3 | vs FLO | 7 | 166 | W | 6.1 | 7 | 2 | 2 | 0 | 2 | 2 | 92 | 25 | 67 | 73% | 4-0 | 3.43 | 1.21 |
| 2010-05-14 | Tom Gorzelanny | L | 28 | W 6-10 | vs PIT | 7 | 79 | - | 5.0 | 9 | 5 | 5 | 0 | 4 | 7 | 112 | 46 | 66 | 59% | 1-4 | 3.60 | 1.38 |
| 2010-05-15 | Ryan Dempster | R | 33 | W 3-4 | vs PIT | 8 | 234 | L | 7.0 | 4 | 3 | 3 | 0 | 5 | 9 | 122 | 50 | 72 | 59% | 2-4 | 3.47 | 1.09 |
| 2010-05-16 | Ted Lilly | L | 34 | L 4-3 | vs PIT | 5 | 260 | - | 7.0 | 6 | 3 | 3 | 0 | 3 | 4 | 109 | 39 | 70 | 64% | 1-3 | 4.65 | 1.19 |
| 2010-05-17 | Randy Wells | R | 28 | L 4-2 | vs COL | 8 | 35 | - | 6.2 | 7 | 1 | 1 | 0 | 1 | 3 | 116 | 39 | 77 | 66% | 3-2 | 4.13 | 1.31 |
| 2010-05-18 | Carlos Silva | R | 31 | L 6-2 | vs COL | 8 | 167 | W | 6.0 | 6 | 2 | 2 | 1 | 1 | 4 | 85 | 27 | 58 | 68% | 5-0 | 3.38 | 1.21 |
| 2010-05-19 | Tom Gorzelanny | L | 28 | W 4-1 | @ PHI | 8 | 80 | W | 6.2 | 3 | 0 | 0 | 0 | 2 | 5 | 103 | 39 | 64 | 62% | 2-4 | 3.06 | 1.28 |
| 2010-05-20 | Ryan Dempster | R | 33 | L 4-5 | @ PHI | 9 | 235 | - | 6.0 | 5 | 4 | 4 | 2 | 2 | 3 | 89 | 31 | 58 | 65% | 2-4 | 3.71 | 1.10 |
| 2010-05-21 | Ted Lilly | L | 34 | L 1-2 | @ TEX | 6 | 261 | L | 6.2 | 6 | 2 | 2 | 0 | 3 | 4 | 113 | 36 | 77 | 68% | 1-4 | 4.26 | 1.21 |
| 2010-05-22 | Randy Wells | R | 28 | W 5-4 | @ TEX | 9 | 36 | - | 8.1 | 7 | 3 | 3 | 2 | 1 | 6 | 104 | 32 | 72 | 69% | 3-2 | 4.02 | 1.27 |
| 2010-05-23 | Carlos Silva | R | 31 | W 5-4 | @ TEX | 9 | 168 | W | 5.1 | 6 | 3 | 3 | 1 | 1 | 1 | 81 | 31 | 50 | 62% | 6-0 | 3.50 | 1.20 |
| 2010-05-25 | Ryan Dempster | R | 33 | L 3-0 | vs LAN | 10 | 236 | W | 8.0 | 3 | 0 | 0 | 0 | 1 | 7 | 104 | 40 | 64 | 62% | 3-4 | 3.30 | 1.03 |
| 2010-05-26 | Tom Gorzelanny | L | 28 | W 5-8 | vs LAN | 9 | 81 | L | 5.0 | 7 | 7 | 5 | 0 | 3 | 5 | 110 | 42 | 68 | 62% | 2-5 | 3.63 | 1.35 |
| 2010-05-27 | Ted Lilly | L | 34 | L 1-0 | vs LAN | 7 | 262 | - | 7.0 | 3 | 0 | 0 | 0 | 3 | 5 | 111 | 39 | 72 | 65% | 1-4 | 3.60 | 1.16 |
| 2010-05-28 | Randy Wells | R | 28 | W 1-7 | vs SLN | 10 | 37 | L | 0.0 | 6 | 5 | 5 | 0 | 0 | 0 | 16 | 5 | 11 | 69% | 3-3 | 4.82 | 1.38 |
| 2010-05-29 | Carlos Silva | R | 31 | L 5-0 | vs SLN | 10 | 169 | W | 7.0 | 2 | 0 | 0 | 0 | 0 | 11 | 98 | 33 | 65 | 66% | 7-0 | 3.10 | 1.10 |
| 2010-05-30 | Ryan Dempster | R | 33 | W 1-9 | vs SLN | 11 | 237 | L | 6.2 | 9 | 6 | 6 | 2 | 3 | 7 | 124 | 49 | 75 | 60% | 3-5 | 3.74 | 1.10 |
| 2010-05-31 | Randy Wells | R | 28 | L 1-2 | @ PIT | 11 | 38 | - | 5.0 | 3 | 0 | 0 | 0 | 3 | 3 | 90 | 38 | 52 | 58% | 3-3 | 4.43 | 1.36 |
| 2010-06-01 | Ted Lilly | L | 34 | L 2-3 | @ PIT | 8 | 263 | L | 7.2 | 6 | 3 | 3 | 2 | 4 | 6 | 113 | 44 | 69 | 61% | 1-5 | 3.63 | 1.19 |
| 2010-06-04 | Carlos Zambrano | R | 29 | L 1-3 | @ HOU | 5 | 243 | L | 4.1 | 6 | 3 | 3 | 0 | 3 | 3 | 85 | 39 | 46 | 54% | 1-4 | 6.08 | 1.73 |
| 2010-06-05 | Ryan Dempster | R | 33 | W 8-5 | @ HOU | 12 | 238 | W | 6.1 | 6 | 3 | 3 | 2 | 2 | 7 | 102 | 36 | 66 | 65% | 4-5 | 3.75 | 1.11 |
| 2010-06-06 | Randy Wells | R | 28 | L 3-6 | @ HOU | 12 | 39 | L | 5.1 | 9 | 6 | 6 | 1 | 2 | 2 | 90 | 38 | 52 | 58% | 3-4 | 4.84 | 1.40 |
| 2010-06-07 | Carlos Silva | R | 31 | W 6-1 | @ PIT | 11 | 170 | W | 7.0 | 4 | 1 | 1 | 0 | 1 | 5 | 102 | 27 | 75 | 74% | 8-0 | 2.91 | 1.06 |
| 2010-06-08 | Ted Lilly | L | 34 | L 2-3 | @ MIL | 9 | 264 | - | 8.0 | 4 | 1 | 1 | 1 | 0 | 8 | 91 | 22 | 69 | 76% | 1-5 | 3.30 | 1.10 |
| 2010-06-09 | Carlos Zambrano | R | 29 | W 9-4 | @ MIL | 6 | 244 | W | 5.0 | 2 | 3 | 3 | 0 | 5 | 2 | 88 | 42 | 46 | 52% | 2-4 | 6.00 | 1.69 |
| 2010-06-10 | Ryan Dempster | R | 33 | L 4-5 | @ MIL | 13 | 239 | - | 5.1 | 5 | 3 | 2 | 1 | 5 | 3 | 100 | 48 | 52 | 52% | 4-5 | 3.74 | 1.16 |
| 2010-06-11 | Randy Wells | R | 28 | W 5-10 | vs CHA | 13 | 40 | L | 5.0 | 10 | 5 | 5 | 0 | 3 | 6 | 86 | 37 | 49 | 57% | 3-5 | 5.13 | 1.49 |
| 2010-06-12 | Carlos Silva | R | 31 | W 1-2 | vs CHA | 12 | 171 | L | 7.0 | 7 | 2 | 2 | 0 | 2 | 6 | 123 | 42 | 81 | 66% | 8-1 | 2.88 | 1.08 |
| 2010-06-13 | Ted Lilly | L | 34 | L 1-0 | vs CHA | 10 | 265 | W | 8.0 | 1 | 0 | 0 | 0 | 1 | 3 | 107 | 36 | 71 | 66% | 2-5 | 2.91 | 1.00 |
| 2010-06-15 | Carlos Zambrano | R | 29 | W 5-9 | vs OAK | 7 | 245 | L | 6.0 | 7 | 5 | 2 | 0 | 3 | 4 | 102 | 38 | 64 | 63% | 2-5 | 5.63 | 1.69 |
| 2010-06-16 | Ryan Dempster | R | 33 | L 6-2 | vs OAK | 14 | 240 | W | 6.2 | 8 | 2 | 2 | 0 | 2 | 7 | 120 | 48 | 72 | 60% | 5-5 | 3.66 | 1.18 |
| 2010-06-17 | Randy Wells | R | 28 | L 3-2 | vs OAK | 14 | 41 | - | 7.0 | 7 | 2 | 2 | 1 | 1 | 6 | 125 | 52 | 73 | 58% | 3-5 | 4.90 | 1.46 |
| 2010-06-18 | Carlos Silva | R | 31 | W 6-7 | vs ANA | 13 | 172 | L | 6.0 | 6 | 3 | 3 | 1 | 0 | 4 | 69 | 20 | 49 | 71% | 8-2 | 3.00 | 1.07 |
| 2010-06-19 | Ted Lilly | L | 34 | W 0-12 | vs ANA | 11 | 266 | L | 5.1 | 9 | 8 | 6 | 2 | 3 | 7 | 104 | 33 | 71 | 68% | 2-6 | 3.41 | 1.08 |
| 2010-06-20 | Carlos Zambrano | R | 29 | L 12-1 | vs ANA | 8 | 246 | W | 7.0 | 8 | 1 | 1 | 0 | 1 | 7 | 107 | 38 | 69 | 64% | 3-5 | 5.07 | 1.64 |
| 2010-06-22 | Ryan Dempster | R | 33 | L 0-2 | @ SEA | 15 | 241 | L | 8.0 | 5 | 2 | 2 | 1 | 2 | 8 | 116 | 36 | 80 | 69% | 5-6 | 3.55 | 1.15 |
| 2010-06-23 | Randy Wells | R | 28 | L 1-8 | @ SEA | 15 | 42 | L | 6.0 | 10 | 6 | 6 | 0 | 2 | 3 | 113 | 49 | 64 | 57% | 3-6 | 5.19 | 1.49 |
| 2010-06-24 | Ted Lilly | L | 34 | W 3-2 | @ SEA | 12 | 267 | - | 6.0 | 5 | 1 | 1 | 0 | 0 | 6 | 105 | 27 | 78 | 74% | 2-6 | 3.26 | 1.06 |
| 2010-06-25 | Carlos Zambrano | R | 29 | L 0-6 | @ CHA | 9 | 247 | L | 1.0 | 4 | 4 | 4 | 1 | 0 | 1 | 21 | 6 | 15 | 71% | 3-6 | 5.63 | 1.68 |
| 2010-06-26 | Carlos Silva | R | 31 | L 2-3 | @ CHA | 14 | 173 | - | 6.0 | 3 | 2 | 2 | 0 | 1 | 4 | 113 | 45 | 68 | 60% | 8-2 | 3.00 | 1.05 |
| 2010-06-27 | Ryan Dempster | R | 33 | W 8-6 | @ CHA | 16 | 242 | W | 7.0 | 9 | 3 | 3 | 1 | 1 | 8 | 134 | 47 | 87 | 65% | 6-6 | 3.57 | 1.17 |
| 2010-06-28 | Randy Wells | R | 28 | W 1-2 | vs PIT | 16 | 43 | - | 6.0 | 3 | 1 | 1 | 0 | 4 | 6 | 108 | 47 | 61 | 56% | 3-6 | 4.95 | 1.47 |
| 2010-06-29 | Ted Lilly | L | 34 | L 3-1 | vs PIT | 13 | 268 | W | 7.0 | 6 | 1 | 1 | 1 | 1 | 5 | 101 | 28 | 73 | 72% | 3-6 | 3.10 | 1.06 |
| 2010-06-30 | Tom Gorzelanny | L | 28 | W 0-2 | vs PIT | 10 | 82 | - | 5.0 | 4 | 0 | 0 | 0 | 3 | 5 | 76 | 26 | 50 | 66% | 2-5 | 3.14 | 1.37 |
| 2010-07-01 | Carlos Silva | R | 31 | W 2-3 | vs CIN | 15 | 174 | - | 7.2 | 11 | 2 | 2 | 0 | 0 | 6 | 105 | 31 | 74 | 70% | 8-2 | 2.97 | 1.09 |
| 2010-07-02 | Ryan Dempster | R | 33 | W 0-12 | vs CIN | 17 | 243 | L | 6.1 | 2 | 5 | 2 | 1 | 5 | 9 | 116 | 52 | 64 | 55% | 6-7 | 3.54 | 1.17 |
| 2010-07-03 | Randy Wells | R | 28 | L 3-1 | vs CIN | 17 | 44 | W | 7.2 | 5 | 1 | 1 | 0 | 1 | 5 | 98 | 28 | 70 | 71% | 4-6 | 4.68 | 1.43 |
| 2010-07-04 | Ted Lilly | L | 34 | W 3-14 | vs CIN | 14 | 269 | L | 6.2 | 11 | 9 | 9 | 4 | 0 | 3 | 97 | 24 | 73 | 75% | 3-7 | 3.77 | 1.11 |
| 2010-07-05 | Tom Gorzelanny | L | 28 | W 9-4 | @ ARI | 11 | 83 | W | 5.0 | 5 | 3 | 3 | 1 | 6 | 4 | 106 | 44 | 62 | 58% | 3-5 | 3.31 | 1.43 |
| 2010-07-06 | Carlos Silva | R | 31 | W 6-4 | @ ARI | 16 | 175 | W | 6.0 | 4 | 2 | 2 | 1 | 1 | 3 | 75 | 25 | 50 | 67% | 9-2 | 2.97 | 1.07 |
| 2010-07-07 | Ryan Dempster | R | 33 | W 8-3 | @ ARI | 18 | 244 | W | 5.0 | 8 | 3 | 3 | 0 | 1 | 6 | 100 | 37 | 63 | 63% | 7-7 | 3.61 | 1.20 |
| 2010-07-08 | Randy Wells | R | 28 | L 2-3 | @ LAN | 18 | 45 | L | 7.0 | 6 | 3 | 3 | 1 | 1 | 7 | 106 | 40 | 66 | 62% | 4-7 | 4.63 | 1.40 |
| 2010-07-09 | Ted Lilly | L | 35 | L 7-9 | @ LAN | 15 | 270 | L | 3.2 | 7 | 7 | 5 | 1 | 2 | 1 | 76 | 31 | 45 | 59% | 3-8 | 4.08 | 1.15 |
| 2010-07-10 | Tom Gorzelanny | L | 28 | W 7-3 | @ LAN | 12 | 84 | W | 6.0 | 6 | 2 | 1 | 0 | 1 | 7 | 105 | 36 | 69 | 66% | 4-5 | 3.16 | 1.41 |
| 2010-07-11 | Carlos Silva | R | 31 | L 0-7 | @ LAN | 17 | 176 | L | 1.1 | 6 | 6 | 6 | 1 | 3 | 2 | 40 | 19 | 21 | 53% | 9-3 | 3.44 | 1.14 |
| 2010-07-15 | Ryan Dempster | R | 33 | L 12-6 | vs PHI | 19 | 245 | W | 6.2 | 6 | 2 | 2 | 1 | 3 | 9 | 101 | 41 | 60 | 59% | 8-7 | 3.56 | 1.20 |
| 2010-07-16 | Ted Lilly | L | 35 | L 4-3 | vs PHI | 16 | 271 | - | 7.0 | 4 | 3 | 3 | 2 | 1 | 10 | 109 | 40 | 69 | 63% | 3-8 | 4.07 | 1.13 |
| 2010-07-17 | Randy Wells | R | 28 | W 1-4 | vs PHI | 19 | 46 | - | 7.0 | 7 | 0 | 0 | 0 | 2 | 5 | 103 | 42 | 61 | 59% | 4-7 | 4.34 | 1.39 |
| 2010-07-18 | Tom Gorzelanny | L | 28 | L 11-6 | vs PHI | 13 | 85 | W | 6.2 | 5 | 3 | 2 | 0 | 5 | 5 | 113 | 44 | 69 | 61% | 5-5 | 3.11 | 1.41 |
| 2010-07-19 | Carlos Silva | R | 31 | W 5-11 | vs HOU | 18 | 177 | L | 1.0 | 7 | 5 | 5 | 0 | 2 | 0 | 41 | 16 | 25 | 61% | 9-4 | 3.84 | 1.21 |
| 2010-07-20 | Ryan Dempster | R | 33 | L 14-7 | vs HOU | 20 | 246 | - | 5.0 | 8 | 7 | 4 | 1 | 4 | 1 | 112 | 44 | 68 | 61% | 8-7 | 3.69 | 1.25 |
| 2010-07-21 | Ted Lilly | L | 35 | W 3-4 | vs HOU | 17 | 272 | - | 7.1 | 7 | 1 | 1 | 1 | 1 | 6 | 109 | 33 | 76 | 70% | 3-8 | 3.89 | 1.13 |
| 2010-07-23 | Randy Wells | R | 28 | L 5-0 | vs SLN | 20 | 47 | W | 7.0 | 5 | 0 | 0 | 0 | 3 | 7 | 107 | 42 | 65 | 61% | 5-7 | 4.08 | 1.38 |
| 2010-07-24 | Tom Gorzelanny | L | 28 | L 6-5 | vs SLN | 14 | 86 | W | 6.0 | 7 | 3 | 3 | 0 | 3 | 3 | 98 | 37 | 61 | 62% | 6-5 | 3.21 | 1.43 |
| 2010-07-25 | Ryan Dempster | R | 33 | W 3-4 | vs SLN | 21 | 247 | - | 7.0 | 9 | 3 | 3 | 1 | 4 | 4 | 98 | 40 | 58 | 59% | 8-7 | 3.70 | 1.28 |
| 2010-07-26 | Carlos Silva | R | 31 | W 5-2 | @ HOU | 19 | 178 | W | 5.0 | 5 | 1 | 1 | 0 | 1 | 4 | 94 | 38 | 56 | 60% | 10-4 | 3.75 | 1.21 |
| 2010-07-27 | Ted Lilly | L | 35 | L 1-6 | @ HOU | 18 | 273 | - | 5.2 | 5 | 0 | 0 | 0 | 3 | 8 | 114 | 46 | 68 | 60% | 3-8 | 3.69 | 1.14 |
| 2010-07-28 | Randy Wells | R | 28 | L 1-8 | @ HOU | 21 | 48 | L | 5.2 | 5 | 3 | 3 | 1 | 5 | 4 | 93 | 40 | 53 | 57% | 5-8 | 4.10 | 1.39 |
| 2010-07-30 | Ryan Dempster | R | 33 | L 2-17 | @ COL | 22 | 248 | L | 4.0 | 7 | 5 | 5 | 1 | 5 | 5 | 103 | 41 | 62 | 60% | 8-8 | 3.91 | 1.32 |
| 2010-07-31 | Tom Gorzelanny | L | 28 | L 5-6 | @ COL | 15 | 87 | - | 6.1 | 9 | 5 | 5 | 1 | 2 | 5 | 94 | 32 | 62 | 66% | 6-5 | 3.48 | 1.45 |
| 2010-08-01 | Carlos Silva | R | 31 | L 7-8 | @ COL | 20 | 179 | L | 0.1 | 2 | 2 | 2 | 0 | 1 | 0 | 15 | 7 | 8 | 53% | 10-5 | 3.92 | 1.24 |
| 2010-08-02 | Randy Wells | R | 28 | W 1-18 | vs MIL | 22 | 49 | L | 4.0 | 10 | 7 | 6 | 1 | 0 | 5 | 69 | 18 | 51 | 74% | 5-9 | 4.40 | 1.43 |
| 2010-08-03 | Thomas Diamond | R | 27 | W 3-4 | vs MIL | 1 | 1 | L | 6.0 | 7 | 3 | 3 | 0 | 3 | 10 | 120 | 45 | 75 | 63% | 0-1 | 4.50 | 1.67 |
| 2010-08-04 | Ryan Dempster | R | 33 | L 15-3 | vs MIL | 23 | 249 | W | 6.0 | 3 | 3 | 0 | 0 | 3 | 5 | 94 | 45 | 49 | 52% | 9-8 | 3.75 | 1.31 |
| 2010-08-06 | Tom Gorzelanny | L | 28 | W 0-3 | vs CIN | 16 | 88 | L | 7.0 | 4 | 3 | 3 | 1 | 4 | 5 | 117 | 41 | 76 | 65% | 6-6 | 3.51 | 1.43 |
| 2010-08-07 | Randy Wells | R | 28 | W 3-4 | vs CIN | 23 | 50 | L | 7.0 | 5 | 3 | 3 | 1 | 2 | 3 | 82 | 28 | 54 | 66% | 5-10 | 4.37 | 1.40 |
| 2010-08-08 | Thomas Diamond | R | 27 | W 4-11 | vs CIN | 2 | 2 | L | 3.0 | 4 | 5 | 5 | 0 | 3 | 1 | 62 | 26 | 36 | 58% | 0-2 | 8.00 | 1.89 |
| 2010-08-09 | Carlos Zambrano | R | 29 | L 3-4 | @ SFN | 10 | 248 | - | 5.0 | 4 | 2 | 2 | 0 | 7 | 3 | 100 | 48 | 52 | 52% | 3-6 | 5.48 | 1.80 |
| 2010-08-10 | Ryan Dempster | R | 33 | W 8-6 | @ SFN | 24 | 250 | W | 6.2 | 8 | 4 | 1 | 0 | 2 | 3 | 113 | 38 | 75 | 66% | 10-8 | 3.67 | 1.32 |
| 2010-08-11 | Tom Gorzelanny | L | 28 | L 4-5 | @ SFN | 17 | 89 | - | 6.0 | 8 | 4 | 4 | 1 | 1 | 5 | 97 | 34 | 63 | 65% | 6-6 | 3.65 | 1.43 |
| 2010-08-12 | Randy Wells | R | 28 | L 7-8 | @ SFN | 24 | 51 | - | 5.0 | 8 | 7 | 6 | 3 | 3 | 2 | 102 | 51 | 51 | 50% | 5-10 | 4.60 | 1.43 |
| 2010-08-13 | Thomas Diamond | R | 27 | L 3-6 | @ SLN | 3 | 3 | L | 4.0 | 6 | 4 | 4 | 1 | 4 | 2 | 91 | 40 | 51 | 56% | 0-3 | 8.31 | 2.08 |
| 2010-08-14 | Carlos Zambrano | R | 29 | W 3-2 | @ SLN | 11 | 249 | W | 5.2 | 7 | 2 | 2 | 0 | 2 | 3 | 99 | 36 | 63 | 64% | 4-6 | 5.27 | 1.77 |
| 2010-08-15 | Ryan Dempster | R | 33 | W 9-7 | @ SLN | 25 | 251 | W | 6.2 | 5 | 2 | 2 | 1 | 2 | 6 | 119 | 44 | 75 | 63% | 11-8 | 3.62 | 1.31 |
| 2010-08-16 | Tom Gorzelanny | L | 28 | W 5-9 | vs SDN | 18 | 90 | L | 6.1 | 9 | 5 | 5 | 0 | 3 | 2 | 120 | 50 | 70 | 58% | 6-7 | 3.86 | 1.46 |
| 2010-08-17 | Randy Wells | R | 28 | W 0-1 | vs SDN | 25 | 52 | L | 7.0 | 3 | 1 | 1 | 0 | 3 | 6 | 120 | 51 | 69 | 58% | 5-11 | 4.44 | 1.41 |
| 2010-08-18 | Casey Coleman | R | 23 | W 1-5 | vs SDN | 1 | 1 | L | 4.1 | 6 | 3 | 3 | 1 | 3 | 1 | 82 | 37 | 45 | 55% | 0-1 | 7.62 | 1.85 |
| 2010-08-19 | Carlos Zambrano | R | 29 | W 3-5 | vs SDN | 12 | 250 | - | 6.0 | 4 | 1 | 1 | 0 | 6 | 1 | 112 | 50 | 62 | 55% | 4-6 | 4.97 | 1.76 |
| 2010-08-20 | Ryan Dempster | R | 33 | W 3-5 | vs ATL | 26 | 252 | - | 8.0 | 4 | 2 | 2 | 1 | 2 | 7 | 104 | 40 | 64 | 62% | 11-8 | 3.56 | 1.28 |
| 2010-08-21 | Tom Gorzelanny | L | 28 | L 5-4 | vs ATL | 19 | 91 | W | 7.0 | 7 | 1 | 1 | 0 | 2 | 9 | 117 | 43 | 74 | 63% | 7-7 | 3.71 | 1.45 |
| 2010-08-22 | Randy Wells | R | 28 | W 5-16 | vs ATL | 26 | 53 | L | 6.0 | 7 | 7 | 5 | 3 | 4 | 5 | 103 | 39 | 64 | 62% | 5-12 | 4.56 | 1.42 |
| 2010-08-23 | Casey Coleman | R | 23 | W 9-1 | @ WAS | 2 | 2 | W | 6.1 | 3 | 1 | 1 | 0 | 2 | 3 | 103 | 41 | 62 | 60% | 1-1 | 5.68 | 1.53 |
| 2010-08-24 | Carlos Zambrano | R | 29 | W 5-4 | @ WAS | 13 | 251 | W | 7.1 | 5 | 1 | 1 | 0 | 1 | 8 | 108 | 40 | 68 | 63% | 5-6 | 4.66 | 1.69 |
| 2010-08-25 | Ryan Dempster | R | 33 | W 4-0 | @ WAS | 27 | 253 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 8 | 80 | 23 | 57 | 71% | 12-8 | 3.42 | 1.25 |
| 2010-08-27 | Tom Gorzelanny | L | 28 | L 1-7 | @ CIN | 20 | 92 | L | 5.0 | 7 | 6 | 6 | 3 | 2 | 1 | 90 | 34 | 56 | 62% | 7-8 | 3.99 | 1.47 |
| 2010-08-28 | Randy Wells | R | 28 | W 3-2 | @ CIN | 27 | 54 | W | 6.0 | 6 | 2 | 2 | 1 | 2 | 4 | 100 | 39 | 61 | 61% | 6-12 | 4.50 | 1.42 |
| 2010-08-29 | Casey Coleman | R | 23 | L 5-7 | @ CIN | 3 | 3 | - | 6.0 | 8 | 4 | 4 | 1 | 0 | 2 | 85 | 29 | 56 | 66% | 1-1 | 5.76 | 1.48 |
| 2010-08-30 | Carlos Zambrano | R | 29 | L 14-2 | vs PIT | 14 | 252 | W | 5.1 | 4 | 1 | 0 | 0 | 4 | 7 | 111 | 49 | 62 | 56% | 6-6 | 4.35 | 1.66 |
| 2010-08-31 | Ryan Dempster | R | 33 | W 7-14 | vs PIT | 28 | 254 | L | 3.0 | 7 | 7 | 7 | 0 | 3 | 4 | 70 | 27 | 43 | 61% | 12-9 | 3.71 | 1.29 |
| 2010-09-01 | Tom Gorzelanny | L | 28 | L 5-3 | vs PIT | 21 | 93 | - | 2.2 | 2 | 0 | 0 | 0 | 1 | 1 | 37 | 17 | 20 | 54% | 7-8 | 3.90 | 1.46 |
| 2010-09-03 | Randy Wells | R | 28 | L 7-6 | vs NYN | 28 | 55 | - | 5.2 | 8 | 4 | 4 | 0 | 4 | 4 | 102 | 43 | 59 | 58% | 6-12 | 4.55 | 1.44 |
| 2010-09-04 | Carlos Zambrano | R | 29 | L 5-3 | vs NYN | 15 | 253 | W | 7.0 | 4 | 2 | 2 | 1 | 2 | 8 | 102 | 39 | 63 | 62% | 7-6 | 4.22 | 1.60 |
| 2010-09-05 | Ryan Dempster | R | 33 | W 5-18 | vs NYN | 29 | 255 | L | 4.2 | 9 | 7 | 3 | 0 | 4 | 5 | 105 | 42 | 63 | 60% | 12-10 | 3.75 | 1.32 |
| 2010-09-06 | Casey Coleman | R | 23 | L 5-4 | vs HOU | 4 | 4 | - | 6.0 | 8 | 4 | 4 | 1 | 5 | 2 | 116 | 57 | 59 | 51% | 1-1 | 5.81 | 1.61 |
| 2010-09-07 | Carlos Silva | R | 31 | W 3-7 | vs HOU | 21 | 180 | L | 5.0 | 9 | 6 | 6 | 1 | 1 | 4 | 87 | 33 | 54 | 62% | 10-6 | 4.22 | 1.27 |
| 2010-09-08 | Randy Wells | R | 28 | W 0-4 | vs HOU | 29 | 56 | L | 6.0 | 9 | 4 | 4 | 1 | 2 | 3 | 97 | 38 | 59 | 61% | 6-13 | 4.60 | 1.45 |
| 2010-09-10 | Carlos Zambrano | R | 29 | W 4-0 | @ MIL | 16 | 254 | W | 8.2 | 3 | 0 | 0 | 0 | 3 | 9 | 120 | 48 | 72 | 60% | 8-6 | 3.89 | 1.54 |
| 2010-09-11 | Ryan Dempster | R | 33 | W 1-0 | @ MIL | 30 | 256 | W | 7.0 | 3 | 0 | 0 | 0 | 2 | 8 | 104 | 36 | 68 | 65% | 13-10 | 3.62 | 1.30 |
| 2010-09-12 | Casey Coleman | R | 23 | L 0-2 | @ MIL | 5 | 5 | L | 6.0 | 5 | 1 | 1 | 0 | 3 | 3 | 91 | 43 | 48 | 53% | 1-2 | 5.11 | 1.57 |
| 2010-09-13 | Jeff Samardzija | R | 26 | W 5-1 | @ SLN | 1 | 3 | W | 5.2 | 6 | 0 | 0 | 0 | 4 | 1 | 105 | 41 | 64 | 61% | 1-1 | 7.00 | 2.33 |
| 2010-09-14 | Randy Wells | R | 28 | W 7-2 | @ SLN | 30 | 57 | W | 8.0 | 5 | 1 | 1 | 0 | 0 | 5 | 101 | 34 | 67 | 66% | 7-13 | 4.45 | 1.42 |
| 2010-09-15 | Carlos Zambrano | R | 29 | W 7-3 | @ SLN | 17 | 255 | W | 6.0 | 4 | 2 | 1 | 0 | 3 | 3 | 104 | 46 | 58 | 56% | 9-6 | 3.76 | 1.52 |
| 2010-09-17 | Ryan Dempster | R | 33 | W 2-0 | @ FLO | 31 | 257 | W | 7.0 | 4 | 0 | 0 | 0 | 3 | 5 | 126 | 53 | 73 | 58% | 14-10 | 3.49 | 1.29 |
| 2010-09-18 | Casey Coleman | R | 23 | W 5-3 | @ FLO | 6 | 6 | W | 6.0 | 5 | 3 | 3 | 0 | 4 | 5 | 90 | 36 | 54 | 60% | 2-2 | 5.02 | 1.56 |
| 2010-09-19 | Jeff Samardzija | R | 26 | W 13-3 | @ FLO | 2 | 4 | W | 6.0 | 3 | 3 | 3 | 2 | 3 | 4 | 91 | 35 | 56 | 62% | 2-1 | 6.00 | 1.80 |
| 2010-09-21 | Carlos Zambrano | R | 29 | W 0-1 | vs SFN | 18 | 256 | - | 6.0 | 3 | 0 | 0 | 0 | 5 | 8 | 114 | 56 | 58 | 51% | 9-6 | 3.57 | 1.51 |
| 2010-09-22 | Randy Wells | R | 28 | L 2-0 | vs SFN | 31 | 58 | W | 7.2 | 6 | 0 | 0 | 0 | 1 | 6 | 90 | 27 | 63 | 70% | 8-13 | 4.28 | 1.40 |
| 2010-09-23 | Ryan Dempster | R | 33 | W 0-13 | vs SFN | 32 | 258 | L | 1.2 | 7 | 9 | 9 | 1 | 2 | 2 | 53 | 23 | 30 | 57% | 14-11 | 3.88 | 1.33 |
| 2010-09-24 | Tom Gorzelanny | L | 28 | W 1-7 | vs SLN | 22 | 94 | L | 3.1 | 7 | 7 | 7 | 1 | 5 | 4 | 82 | 38 | 44 | 54% | 7-9 | 4.29 | 1.52 |
| 2010-09-25 | Casey Coleman | R | 23 | L 7-3 | vs SLN | 7 | 7 | W | 7.0 | 5 | 3 | 2 | 0 | 2 | 4 | 92 | 37 | 55 | 60% | 3-2 | 4.68 | 1.48 |
| 2010-09-26 | Jeff Samardzija | R | 26 | W 7-8 | vs SLN | 3 | 5 | L | 4.1 | 7 | 8 | 8 | 1 | 7 | 2 | 94 | 45 | 49 | 52% | 2-2 | 8.53 | 2.16 |
| 2010-09-27 | Carlos Zambrano | R | 29 | W 1-0 | @ SDN | 19 | 257 | W | 7.0 | 3 | 0 | 0 | 0 | 4 | 5 | 106 | 47 | 59 | 56% | 10-6 | 3.37 | 1.48 |
| 2010-09-28 | Ryan Dempster | R | 33 | W 5-2 | @ SDN | 33 | 259 | W | 7.0 | 4 | 2 | 2 | 1 | 2 | 9 | 107 | 39 | 68 | 64% | 15-11 | 3.83 | 1.31 |
| 2010-09-29 | Randy Wells | R | 28 | L 0-3 | @ SDN | 32 | 59 | L | 7.0 | 6 | 3 | 3 | 0 | 4 | 2 | 116 | 57 | 59 | 51% | 8-14 | 4.27 | 1.40 |
| 2010-09-30 | Tom Gorzelanny | L | 28 | W 1-0 | @ SDN | 23 | 95 | - | 6.0 | 3 | 0 | 0 | 0 | 4 | 3 | 91 | 42 | 49 | 54% | 7-9 | 4.10 | 1.50 |
| 2010-10-01 | Casey Coleman | R | 23 | W 2-0 | @ HOU | 8 | 8 | W | 7.0 | 6 | 0 | 0 | 0 | 1 | 2 | 100 | 41 | 59 | 59% | 4-2 | 4.11 | 1.42 |
| 2010-10-02 | Carlos Zambrano | R | 29 | W 8-3 | @ HOU | 20 | 258 | W | 6.1 | 3 | 3 | 2 | 0 | 3 | 5 | 92 | 35 | 57 | 62% | 11-6 | 3.32 | 1.45 |
| 2010-10-03 | Ryan Dempster | R | 33 | L 0-4 | @ HOU | 34 | 260 | L | 6.0 | 9 | 4 | 3 | 1 | 1 | 7 | 124 | 47 | 77 | 62% | 15-12 | 3.85 | 1.32 |