| Vernon Wells | 2010-04-07 | 2010 | W 7-4 @ TEX | 3 | 4 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1238 | 1373 | 195 | 731 | 84 | 2 home runs, 4 runs scored |
| Mike McCoy | 2010-04-08 | 2010 | W 3-1 @ TEX | 5 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 13 | 2 | 0 | 1 | 0 | 1st career hit, 1st career RBI |
| Alex Gonzalez | 2010-04-11 | 2010 | W 5-2 @ BAL | 4 | 2 | 2 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1234 | 1096 | 118 | 525 | 27 | 2 home runs |
| Alex Gonzalez | 2010-04-15 | 2010 | W 7-3 vs TOR | 5 | 1 | 4 | 2 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1238 | 1102 | 118 | 528 | 27 | 4 hits |
| Lyle Overbay | 2010-04-15 | 2010 | W 7-3 vs TOR | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 993 | 939 | 102 | 459 | 12 | 4 strikeouts |
| Mike McCoy | 2010-04-17 | 2010 | L 6-3 vs TOR | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 5 | 0 | 2 | 1 | 1st career stolen base |
| Jose Bautista | 2010-04-19 | 2010 | W 8-1 vs TOR | 4 | 2 | 2 | 0 | 0 | 2 | 5 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 589 | 429 | 62 | 221 | 15 | 2 home runs, 5 RBis |
| Jose Bautista | 2010-04-23 | 2010 | W 6-5 @ TBA | 5 | 0 | 3 | 3 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 592 | 433 | 62 | 223 | 16 | 3 Doubles |
| Lyle Overbay | 2010-04-23 | 2010 | W 6-5 @ TBA | 4 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 1000 | 944 | 102 | 461 | 12 | 1000th career game |
| Rommie Lewis | 2010-04-28 | 2010 | L 2-0 vs TOR | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| John Buck | 2010-04-29 | 2010 | W 6-3 vs TOR | 4 | 3 | 3 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 602 | 462 | 74 | 270 | 4 | 3 home runs, 5 RBis |
| Alex Gonzalez | 2010-04-30 | 2010 | W 10-2 vs TOR | 3 | 2 | 2 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1252 | 1115 | 121 | 540 | 27 | 2 home runs |
| Vernon Wells | 2010-04-30 | 2010 | W 10-2 vs TOR | 4 | 2 | 3 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1260 | 1399 | 200 | 741 | 85 | 200th career home run |
| John Buck | 2010-05-02 | 2010 | W 9-3 vs TOR | 4 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 605 | 467 | 74 | 272 | 4 | 3 Doubles |
| John Buck | 2010-05-07 | 2010 | W 7-4 @ CHA | 5 | 2 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 610 | 471 | 77 | 276 | 4 | 2 home runs |
| Jose Bautista | 2010-05-15 | 2010 | W 6-0 vs TOR | 4 | 2 | 3 | 0 | 0 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 613 | 451 | 68 | 239 | 17 | 2 home runs, 5 RBis |
| Edwin Encarnacion | 2010-05-21 | 2010 | L 8-6 @ ARI | 4 | 3 | 3 | 0 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 569 | 510 | 84 | 297 | 21 | 3 home runs |
| Shawn Camp | 2010-05-23 | 2010 | W 12-4 @ ARI | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 316 | 1 | 0 | 0 | 0 | 1st career hit |
| Shaun Marcum | 2010-05-23 | 2010 | W 12-4 @ ARI | 3 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 29 | 1 | 0 | 1 | 0 | 1st career hit, 1st career RBI |
| Lyle Overbay | 2010-05-29 | 2010 | W 5-2 vs TOR | 4 | 2 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1033 | 973 | 108 | 479 | 13 | 2 home runs |
| Jose Bautista | 2010-06-04 | 2010 | W 6-1 vs TOR | 3 | 3 | 3 | 1 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 631 | 468 | 77 | 256 | 17 | 2 home runs |
| Adam Lind | 2010-06-05 | 2010 | W 3-2 vs TOR | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 402 | 408 | 65 | 238 | 4 | 4 strikeouts |
| John Buck | 2010-06-14 | 2010 | W 6-3 @ SDN | 3 | 2 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 636 | 496 | 81 | 292 | 4 | 2 home runs |
| Aaron Hill | 2010-06-14 | 2010 | W 6-3 @ SDN | 5 | 0 | 3 | 3 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 683 | 723 | 73 | 320 | 22 | 3 Doubles |
| Fred Lewis | 2010-06-16 | 2010 | W 7-1 @ SDN | 5 | 2 | 4 | 1 | 1 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 378 | 318 | 20 | 100 | 38 | 4 hits |
| Jose Bautista | 2010-06-22 | 2010 | L 9-4 vs TOR | 3 | 2 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 645 | 474 | 79 | 260 | 17 | 2 home runs |
| Vernon Wells | 2010-06-24 | 2010 | W 5-0 vs TOR | 4 | 2 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1308 | 1446 | 210 | 770 | 87 | 2 home runs |
| Lyle Overbay | 2010-06-30 | 2010 | L 3-1 @ CLE | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1061 | 1000 | 109 | 485 | 13 | 1000th career hit |
| Marc Rzepczynski | 2010-07-10 | 2010 | W 9-5 vs TOR | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| Yunel Escobar | 2010-07-18 | 2010 | W 10-1 @ BAL | 4 | 2 | 3 | 0 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 449 | 478 | 30 | 188 | 17 | 5 RBis |
| Fred Lewis | 2010-07-18 | 2010 | W 10-1 @ BAL | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 401 | 340 | 22 | 107 | 43 | 2 hit by pitches |
| Jose Bautista | 2010-07-20 | 2010 | W 13-1 @ KCA | 6 | 2 | 3 | 1 | 0 | 1 | 5 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 668 | 497 | 85 | 275 | 17 | 5 RBis |
| John Buck | 2010-07-20 | 2010 | W 13-1 @ KCA | 5 | 3 | 3 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 658 | 522 | 83 | 304 | 4 | 3 Doubles |
| Edwin Encarnacion | 2010-07-20 | 2010 | W 13-1 @ KCA | 5 | 1 | 3 | 3 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 606 | 540 | 89 | 314 | 21 | 3 Doubles |
| Jose Bautista | 2010-07-27 | 2010 | W 8-2 vs TOR | 4 | 3 | 4 | 0 | 0 | 2 | 5 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 675 | 508 | 89 | 286 | 18 | 2 home runs, 5 RBis, 4 hits |
| J.P. Arencibia | 2010-08-07 | 2010 | W 17-11 vs TOR | 5 | 3 | 4 | 1 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 2 | 3 | 0 | 2 home runs, 4 hits, 1st career game, 1st career hit, 1st career home run, 1st career RBI |
| Aaron Hill | 2010-08-07 | 2010 | W 17-11 vs TOR | 5 | 2 | 3 | 1 | 0 | 2 | 4 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 724 | 761 | 82 | 341 | 22 | 2 home runs |
| Lyle Overbay | 2010-08-07 | 2010 | W 17-11 vs TOR | 5 | 1 | 1 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1092 | 1032 | 115 | 502 | 13 | 500th career RBI |
| Jose Molina | 2010-08-16 | 2010 | W 3-1 @ OAK | 4 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 597 | 375 | 24 | 145 | 10 | 4 hits |
| John Buck | 2010-08-20 | 2010 | W 16-2 @ BOS | 5 | 4 | 4 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 668 | 533 | 84 | 310 | 4 | 4 runs scored, 4 hits |
| Lyle Overbay | 2010-08-20 | 2010 | W 16-2 @ BOS | 5 | 3 | 4 | 0 | 0 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1103 | 1042 | 117 | 511 | 13 | 2 home runs, 7 RBis, 4 hits |
| Jose Bautista | 2010-08-23 | 2010 | W 3-2 vs TOR | 3 | 2 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 698 | 531 | 99 | 306 | 19 | 2 home runs |
| Jose Bautista | 2010-08-26 | 2010 | L 7-1 vs TOR | 3 | 1 | 2 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 701 | 534 | 100 | 307 | 19 | 100th career home run |
| Vernon Wells | 2010-09-07 | 2010 | W 8-5 vs TOR | 3 | 2 | 3 | 0 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1370 | 1506 | 219 | 802 | 89 | 2 home runs |
| Adam Lind | 2010-09-08 | 2010 | L 8-1 vs TOR | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 479 | 478 | 77 | 272 | 4 | 4 strikeouts |
| Robert Ray | 2010-09-09 | 2010 | L 4-2 vs TOR | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1st career game |
| Jose Bautista | 2010-09-10 | 2010 | L 9-8 vs TOR | 4 | 2 | 2 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 715 | 549 | 105 | 321 | 21 | 2 home runs |
| Yunel Escobar | 2010-09-17 | 2010 | W 11-9 @ BOS | 6 | 2 | 4 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 493 | 531 | 33 | 199 | 18 | 4 hits |
| Jose Bautista | 2010-09-24 | 2010 | W 6-4 vs TOR | 2 | 3 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 727 | 561 | 111 | 329 | 22 | 2 home runs |
| Yunel Escobar | 2010-09-25 | 2010 | W 5-4 vs TOR | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 500 | 534 | 33 | 199 | 18 | 500th career game |
| Jose Bautista | 2010-09-26 | 2010 | W 5-2 vs TOR | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 729 | 561 | 111 | 329 | 22 | 2 hit by pitches |
| Jose Bautista | 2010-09-30 | 2010 | W 13-2 @ MIN | 5 | 3 | 3 | 0 | 0 | 2 | 5 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 733 | 564 | 113 | 335 | 22 | 2 home runs, 5 RBis |
| Edwin Encarnacion | 2010-09-30 | 2010 | W 13-2 @ MIN | 4 | 3 | 3 | 0 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 649 | 575 | 97 | 330 | 21 | 2 home runs |
| Edwin Encarnacion | 2010-10-03 | 2010 | W 2-1 @ MIN | 3 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 652 | 580 | 100 | 337 | 21 | 100th career home run |