| West | W | L | Pct | GB |
| Texas | 90 | 72 | .556 | -- |
| Oakland | 81 | 81 | .500 | 9.0 |
| LA Angels | 80 | 82 | .494 | 10.0 |
| Seattle | 61 | 101 | .377 | 29.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2010-04-05 | Scott Feldman | R | 27 | L 5-4 | vs TOR | 1 | 57 | - | 7.0 | 5 | 3 | 3 | 2 | 0 | 3 | 100 | 37 | 63 | 63% | 0-0 | 3.86 | 0.71 |
| 2010-04-07 | Rich Harden | R | 28 | W 4-7 | vs TOR | 1 | 128 | - | 3.2 | 1 | 3 | 1 | 1 | 5 | 8 | 88 | 38 | 50 | 57% | 0-0 | 2.25 | 1.50 |
| 2010-04-08 | C.J. Wilson | L | 29 | W 1-3 | vs TOR | 1 | 7 | - | 7.0 | 5 | 0 | 0 | 0 | 2 | 9 | 97 | 35 | 62 | 64% | 0-0 | 0.00 | 1.00 |
| 2010-04-09 | Colby Lewis | R | 31 | L 6-2 | vs SEA | 1 | 35 | W | 7.0 | 5 | 1 | 1 | 0 | 4 | 3 | 103 | 42 | 61 | 59% | 1-0 | 1.29 | 1.29 |
| 2010-04-10 | Matt Harrison | L | 25 | W 3-4 | vs SEA | 1 | 27 | - | 6.0 | 6 | 1 | 1 | 0 | 1 | 4 | 110 | 42 | 68 | 62% | 0-0 | 1.50 | 1.17 |
| 2010-04-11 | Scott Feldman | R | 27 | L 9-2 | vs SEA | 2 | 58 | W | 7.0 | 7 | 2 | 1 | 0 | 1 | 4 | 117 | 47 | 70 | 60% | 1-0 | 2.57 | 0.93 |
| 2010-04-12 | Rich Harden | R | 28 | W 4-2 | @ CLE | 2 | 129 | - | 6.0 | 5 | 2 | 2 | 1 | 3 | 2 | 106 | 46 | 60 | 57% | 0-0 | 2.70 | 1.40 |
| 2010-04-14 | Colby Lewis | R | 31 | W 6-2 | @ CLE | 2 | 36 | W | 5.1 | 3 | 2 | 2 | 0 | 4 | 10 | 113 | 43 | 70 | 62% | 2-0 | 2.25 | 1.33 |
| 2010-04-15 | Matt Harrison | L | 25 | L 2-3 | @ CLE | 2 | 28 | L | 7.0 | 5 | 3 | 1 | 1 | 1 | 3 | 115 | 45 | 70 | 61% | 0-1 | 1.38 | 1.00 |
| 2010-04-16 | C.J. Wilson | L | 29 | L 1-5 | @ NYA | 2 | 8 | L | 6.0 | 7 | 5 | 3 | 0 | 3 | 5 | 115 | 49 | 66 | 57% | 0-1 | 2.08 | 1.31 |
| 2010-04-17 | Scott Feldman | R | 27 | L 3-7 | @ NYA | 3 | 59 | L | 2.1 | 7 | 4 | 4 | 0 | 2 | 2 | 73 | 29 | 44 | 60% | 1-1 | 4.50 | 1.38 |
| 2010-04-18 | Rich Harden | R | 28 | L 2-5 | @ NYA | 3 | 130 | L | 3.2 | 5 | 4 | 4 | 1 | 6 | 5 | 97 | 42 | 55 | 57% | 0-1 | 4.85 | 1.92 |
| 2010-04-20 | Colby Lewis | R | 31 | L 6-7 | @ BOS | 3 | 37 | - | 5.0 | 5 | 3 | 3 | 1 | 2 | 5 | 109 | 36 | 73 | 67% | 2-0 | 3.18 | 1.35 |
| 2010-04-21 | Matt Harrison | L | 25 | L 7-8 | @ BOS | 3 | 29 | - | 4.0 | 5 | 6 | 6 | 3 | 3 | 3 | 75 | 30 | 45 | 60% | 0-1 | 4.24 | 1.24 |
| 2010-04-22 | C.J. Wilson | L | 29 | W 3-0 | @ BOS | 3 | 9 | W | 6.2 | 4 | 0 | 0 | 0 | 2 | 2 | 105 | 41 | 64 | 61% | 1-1 | 1.35 | 1.15 |
| 2010-04-23 | Rich Harden | R | 28 | L 5-4 | vs DET | 4 | 131 | - | 4.1 | 6 | 2 | 2 | 0 | 4 | 5 | 98 | 37 | 61 | 62% | 0-1 | 4.50 | 1.94 |
| 2010-04-24 | Scott Feldman | R | 27 | W 4-8 | vs DET | 4 | 60 | L | 3.2 | 8 | 8 | 4 | 0 | 4 | 1 | 93 | 39 | 54 | 58% | 1-2 | 5.40 | 1.70 |
| 2010-04-25 | Colby Lewis | R | 31 | L 8-4 | vs DET | 4 | 38 | W | 6.1 | 7 | 4 | 4 | 1 | 2 | 10 | 105 | 41 | 64 | 61% | 3-0 | 3.75 | 1.33 |
| 2010-04-26 | Matt Harrison | L | 25 | W 6-8 | vs DET | 4 | 30 | - | 6.0 | 8 | 6 | 6 | 1 | 3 | 5 | 103 | 41 | 62 | 60% | 0-1 | 5.48 | 1.39 |
| 2010-04-27 | C.J. Wilson | L | 29 | L 4-2 | vs CHA | 4 | 10 | W | 6.0 | 5 | 2 | 2 | 0 | 3 | 5 | 103 | 45 | 58 | 56% | 2-1 | 1.73 | 1.19 |
| 2010-04-28 | Rich Harden | R | 28 | L 6-5 | vs CHA | 5 | 132 | W | 6.0 | 4 | 3 | 3 | 1 | 5 | 2 | 87 | 41 | 46 | 53% | 1-1 | 4.50 | 1.83 |
| 2010-04-29 | Scott Feldman | R | 27 | W 5-7 | vs CHA | 5 | 61 | - | 6.0 | 2 | 3 | 1 | 0 | 4 | 4 | 101 | 41 | 60 | 59% | 1-2 | 4.50 | 1.54 |
| 2010-04-30 | Colby Lewis | R | 31 | W 2-0 | @ SEA | 5 | 39 | - | 9.0 | 3 | 0 | 0 | 0 | 1 | 10 | 115 | 37 | 78 | 68% | 3-0 | 2.73 | 1.09 |
| 2010-05-01 | Matt Harrison | L | 25 | W 6-3 | @ SEA | 5 | 31 | W | 6.0 | 7 | 3 | 2 | 0 | 3 | 3 | 127 | 46 | 81 | 64% | 1-1 | 4.97 | 1.45 |
| 2010-05-02 | C.J. Wilson | L | 29 | W 3-1 | @ SEA | 5 | 11 | - | 7.0 | 5 | 1 | 1 | 0 | 3 | 4 | 115 | 49 | 66 | 57% | 2-1 | 1.64 | 1.18 |
| 2010-05-03 | Rich Harden | R | 28 | W 4-2 | @ OAK | 6 | 133 | W | 7.0 | 2 | 0 | 0 | 0 | 0 | 9 | 105 | 31 | 74 | 70% | 2-1 | 3.48 | 1.48 |
| 2010-05-04 | Scott Feldman | R | 27 | L 6-7 | @ OAK | 6 | 62 | L | 7.0 | 10 | 7 | 7 | 1 | 3 | 4 | 111 | 41 | 70 | 63% | 1-3 | 5.45 | 1.61 |
| 2010-05-05 | Colby Lewis | R | 31 | L 1-4 | @ OAK | 6 | 40 | L | 6.0 | 5 | 3 | 3 | 1 | 3 | 6 | 107 | 39 | 68 | 64% | 3-1 | 3.00 | 1.13 |
| 2010-05-06 | Matt Harrison | L | 25 | L 13-12 | vs KCA | 6 | 32 | - | 5.0 | 4 | 4 | 4 | 1 | 3 | 1 | 95 | 34 | 61 | 64% | 1-1 | 5.29 | 1.44 |
| 2010-05-07 | C.J. Wilson | L | 29 | L 4-1 | vs KCA | 6 | 12 | W | 9.0 | 5 | 1 | 1 | 0 | 2 | 4 | 112 | 44 | 68 | 61% | 3-1 | 1.50 | 1.10 |
| 2010-05-08 | Rich Harden | R | 28 | L 3-2 | vs KCA | 7 | 134 | - | 5.0 | 6 | 2 | 2 | 1 | 2 | 3 | 95 | 37 | 58 | 61% | 2-1 | 3.50 | 1.50 |
| 2010-05-09 | Scott Feldman | R | 27 | L 6-4 | vs KCA | 7 | 63 | - | 4.0 | 6 | 4 | 4 | 1 | 2 | 4 | 99 | 34 | 65 | 66% | 1-3 | 5.84 | 1.65 |
| 2010-05-11 | Colby Lewis | R | 31 | W 6-7 | vs OAK | 7 | 41 | - | 7.0 | 6 | 3 | 3 | 1 | 1 | 5 | 102 | 37 | 65 | 64% | 3-1 | 3.13 | 1.11 |
| 2010-05-12 | Derek Holland | L | 24 | L 10-1 | vs OAK | 1 | 22 | W | 6.0 | 5 | 0 | 0 | 0 | 1 | 7 | 101 | 35 | 66 | 65% | 1-0 | 0.00 | 1.00 |
| 2010-05-13 | C.J. Wilson | L | 29 | L 2-1 | vs OAK | 7 | 13 | - | 7.0 | 4 | 1 | 1 | 0 | 3 | 5 | 108 | 47 | 61 | 56% | 3-1 | 1.47 | 1.08 |
| 2010-05-14 | Rich Harden | R | 28 | L 10-16 | @ TOR | 8 | 135 | - | 2.2 | 4 | 7 | 7 | 2 | 6 | 3 | 85 | 41 | 44 | 52% | 2-1 | 4.97 | 1.68 |
| 2010-05-15 | Scott Feldman | R | 27 | L 0-6 | @ TOR | 8 | 64 | L | 7.1 | 9 | 5 | 5 | 1 | 1 | 5 | 118 | 39 | 79 | 67% | 1-4 | 5.93 | 1.61 |
| 2010-05-16 | Colby Lewis | R | 31 | L 2-5 | @ TOR | 8 | 42 | L | 5.2 | 3 | 5 | 5 | 1 | 4 | 5 | 113 | 47 | 66 | 58% | 3-2 | 3.71 | 1.14 |
| 2010-05-17 | Derek Holland | L | 24 | L 4-3 | vs ANA | 2 | 23 | W | 5.1 | 5 | 3 | 3 | 2 | 2 | 3 | 97 | 36 | 61 | 63% | 2-0 | 2.45 | 1.18 |
| 2010-05-18 | C.J. Wilson | L | 29 | L 8-7 | vs ANA | 8 | 14 | - | 4.1 | 7 | 7 | 7 | 2 | 1 | 5 | 91 | 30 | 61 | 67% | 3-1 | 2.55 | 1.15 |
| 2010-05-19 | Rich Harden | R | 28 | L 4-3 | vs BAL | 9 | 136 | - | 5.1 | 8 | 2 | 2 | 0 | 1 | 6 | 101 | 36 | 65 | 64% | 2-1 | 4.70 | 1.66 |
| 2010-05-20 | Scott Feldman | R | 27 | L 13-7 | vs BAL | 9 | 65 | W | 6.0 | 12 | 4 | 4 | 0 | 1 | 5 | 110 | 35 | 75 | 68% | 2-4 | 5.94 | 1.68 |
| 2010-05-21 | Colby Lewis | R | 31 | L 2-1 | vs CHN | 9 | 43 | W | 6.0 | 5 | 1 | 1 | 0 | 3 | 4 | 108 | 39 | 69 | 64% | 4-2 | 3.47 | 1.16 |
| 2010-05-22 | Derek Holland | L | 24 | W 4-5 | vs CHN | 3 | 24 | - | 6.0 | 4 | 3 | 2 | 2 | 0 | 5 | 103 | 36 | 67 | 65% | 2-0 | 2.65 | 1.00 |
| 2010-05-23 | C.J. Wilson | L | 30 | W 4-5 | vs CHN | 9 | 15 | L | 5.2 | 7 | 5 | 5 | 1 | 3 | 5 | 104 | 42 | 62 | 60% | 3-2 | 3.05 | 1.20 |
| 2010-05-25 | Rich Harden | R | 28 | W 8-7 | @ KCA | 10 | 137 | - | 5.1 | 7 | 6 | 5 | 0 | 2 | 5 | 102 | 31 | 71 | 70% | 2-1 | 5.14 | 1.67 |
| 2010-05-26 | Scott Feldman | R | 27 | L 2-5 | @ KCA | 10 | 66 | L | 6.2 | 7 | 4 | 4 | 1 | 1 | 0 | 109 | 39 | 70 | 64% | 2-5 | 5.84 | 1.61 |
| 2010-05-28 | Colby Lewis | R | 31 | L 1-2 | @ MIN | 10 | 44 | L | 6.0 | 5 | 2 | 2 | 0 | 4 | 1 | 110 | 49 | 61 | 55% | 4-3 | 3.43 | 1.19 |
| 2010-05-29 | C.J. Wilson | L | 30 | L 3-8 | @ MIN | 10 | 16 | L | 6.0 | 4 | 5 | 5 | 1 | 2 | 3 | 102 | 40 | 62 | 61% | 3-3 | 3.46 | 1.18 |
| 2010-05-30 | Derek Holland | L | 24 | L 3-6 | @ MIN | 4 | 25 | L | 1.0 | 3 | 3 | 3 | 0 | 3 | 0 | 43 | 24 | 19 | 44% | 2-1 | 4.26 | 1.32 |
| 2010-06-01 | Rich Harden | R | 29 | W 9-6 | @ CHA | 11 | 138 | W | 5.0 | 7 | 4 | 4 | 1 | 3 | 1 | 95 | 36 | 59 | 62% | 3-1 | 5.33 | 1.70 |
| 2010-06-02 | Scott Feldman | R | 27 | W 9-5 | @ CHA | 11 | 67 | W | 8.0 | 8 | 5 | 5 | 2 | 3 | 3 | 114 | 44 | 70 | 61% | 3-5 | 5.82 | 1.58 |
| 2010-06-03 | Colby Lewis | R | 31 | L 3-4 | @ CHA | 11 | 45 | L | 6.1 | 7 | 4 | 4 | 3 | 1 | 7 | 103 | 31 | 72 | 70% | 4-4 | 3.60 | 1.19 |
| 2010-06-04 | C.J. Wilson | L | 30 | L 9-6 | vs TBA | 11 | 17 | W | 5.0 | 6 | 5 | 3 | 0 | 4 | 5 | 102 | 48 | 54 | 53% | 4-3 | 3.60 | 1.24 |
| 2010-06-05 | Tommy Hunter | R | 24 | L 6-1 | vs TBA | 1 | 23 | W | 9.0 | 5 | 1 | 1 | 1 | 0 | 4 | 117 | 41 | 76 | 65% | 1-0 | 1.00 | 0.56 |
| 2010-06-06 | Rich Harden | R | 29 | W 5-9 | vs TBA | 12 | 139 | L | 5.0 | 4 | 4 | 3 | 2 | 3 | 6 | 111 | 41 | 70 | 63% | 3-2 | 5.34 | 1.68 |
| 2010-06-07 | Scott Feldman | R | 27 | W 2-4 | vs SEA | 12 | 68 | L | 5.2 | 9 | 4 | 3 | 1 | 2 | 4 | 118 | 45 | 73 | 62% | 3-6 | 5.70 | 1.61 |
| 2010-06-08 | Colby Lewis | R | 31 | L 7-1 | vs SEA | 12 | 46 | W | 7.0 | 4 | 1 | 1 | 0 | 3 | 5 | 119 | 44 | 75 | 63% | 5-4 | 3.39 | 1.17 |
| 2010-06-09 | C.J. Wilson | L | 30 | L 12-2 | vs SEA | 12 | 18 | W | 7.0 | 4 | 2 | 2 | 0 | 3 | 4 | 114 | 50 | 64 | 56% | 5-3 | 3.51 | 1.22 |
| 2010-06-10 | Tommy Hunter | R | 24 | L 12-3 | vs SEA | 2 | 24 | W | 6.0 | 5 | 3 | 2 | 0 | 3 | 5 | 95 | 38 | 57 | 60% | 2-0 | 1.80 | 0.87 |
| 2010-06-11 | Rich Harden | R | 29 | L 2-6 | @ MIL | 13 | 140 | L | 6.0 | 7 | 6 | 6 | 4 | 3 | 4 | 116 | 41 | 75 | 65% | 3-3 | 5.68 | 1.68 |
| 2010-06-12 | Scott Feldman | R | 27 | W 4-3 | @ MIL | 13 | 69 | W | 6.0 | 4 | 0 | 0 | 0 | 3 | 6 | 116 | 54 | 62 | 53% | 4-6 | 5.26 | 1.57 |
| 2010-06-13 | Colby Lewis | R | 31 | W 7-2 | @ MIL | 13 | 47 | W | 8.0 | 3 | 2 | 2 | 2 | 1 | 10 | 118 | 45 | 73 | 62% | 6-4 | 3.28 | 1.11 |
| 2010-06-15 | C.J. Wilson | L | 30 | W 3-2 | @ FLO | 13 | 19 | - | 6.0 | 2 | 2 | 2 | 1 | 6 | 6 | 122 | 56 | 66 | 54% | 5-3 | 3.47 | 1.23 |
| 2010-06-16 | Tommy Hunter | R | 24 | W 6-3 | @ FLO | 3 | 25 | - | 2.1 | 0 | 1 | 1 | 0 | 2 | 1 | 35 | 19 | 16 | 46% | 2-0 | 2.12 | 0.88 |
| 2010-06-17 | Dustin Nippert | R | 29 | W 6-4 | @ FLO | 1 | 22 | - | 3.0 | 7 | 3 | 3 | 0 | 1 | 4 | 74 | 22 | 52 | 70% | 2-3 | 5.06 | 1.91 |
| 2010-06-18 | Scott Feldman | R | 27 | W 9-3 | @ HOU | 14 | 70 | W | 7.0 | 9 | 3 | 3 | 0 | 1 | 6 | 113 | 42 | 71 | 63% | 5-6 | 5.14 | 1.56 |
| 2010-06-19 | Colby Lewis | R | 31 | W 5-1 | @ HOU | 14 | 48 | W | 9.0 | 2 | 1 | 1 | 0 | 0 | 9 | 104 | 31 | 73 | 70% | 7-4 | 3.06 | 1.02 |
| 2010-06-20 | C.J. Wilson | L | 30 | W 5-4 | @ HOU | 14 | 20 | - | 7.0 | 6 | 4 | 2 | 0 | 3 | 4 | 123 | 50 | 73 | 59% | 5-3 | 3.40 | 1.23 |
| 2010-06-22 | Tommy Hunter | R | 24 | L 6-3 | vs PIT | 4 | 26 | W | 6.0 | 9 | 3 | 2 | 0 | 0 | 6 | 87 | 20 | 67 | 77% | 3-0 | 2.35 | 1.04 |
| 2010-06-23 | Dustin Nippert | R | 29 | L 13-3 | vs PIT | 2 | 23 | - | 3.0 | 4 | 2 | 2 | 0 | 4 | 7 | 80 | 33 | 47 | 59% | 2-3 | 5.14 | 1.97 |
| 2010-06-24 | Scott Feldman | R | 27 | L 6-5 | vs PIT | 15 | 71 | - | 6.0 | 12 | 5 | 5 | 0 | 1 | 7 | 104 | 31 | 73 | 70% | 5-6 | 5.30 | 1.60 |
| 2010-06-25 | Colby Lewis | R | 31 | W 4-7 | vs HOU | 15 | 49 | L | 5.0 | 9 | 5 | 4 | 0 | 1 | 4 | 109 | 43 | 66 | 61% | 7-5 | 3.27 | 1.07 |
| 2010-06-26 | C.J. Wilson | L | 30 | L 7-2 | vs HOU | 15 | 21 | W | 7.0 | 5 | 2 | 2 | 1 | 4 | 3 | 112 | 40 | 72 | 64% | 6-3 | 3.34 | 1.24 |
| 2010-06-27 | Tommy Hunter | R | 24 | L 10-1 | vs HOU | 5 | 27 | W | 6.0 | 5 | 1 | 1 | 0 | 2 | 1 | 85 | 34 | 51 | 60% | 4-0 | 2.17 | 1.07 |
| 2010-06-29 | Scott Feldman | R | 27 | L 5-6 | @ ANA | 16 | 72 | L | 5.2 | 9 | 5 | 5 | 1 | 3 | 2 | 112 | 46 | 66 | 59% | 5-7 | 5.49 | 1.64 |
| 2010-06-30 | Omar Beltre | R | 29 | W 6-4 | @ ANA | 1 | 1 | - | 4.0 | 5 | 3 | 3 | 1 | 4 | 6 | 85 | 37 | 48 | 56% | 0-0 | 6.75 | 2.25 |
| 2010-07-01 | C.J. Wilson | L | 30 | L 1-2 | @ ANA | 16 | 22 | L | 5.2 | 5 | 2 | 2 | 0 | 4 | 4 | 105 | 47 | 58 | 55% | 6-4 | 3.35 | 1.26 |
| 2010-07-02 | Colby Lewis | R | 31 | W 3-5 | vs CHA | 16 | 50 | - | 6.0 | 8 | 3 | 3 | 0 | 2 | 3 | 101 | 34 | 67 | 66% | 7-5 | 3.34 | 1.10 |
| 2010-07-03 | Tommy Hunter | R | 24 | L 3-1 | vs CHA | 6 | 28 | W | 7.0 | 9 | 1 | 1 | 0 | 1 | 3 | 93 | 26 | 67 | 72% | 5-0 | 2.00 | 1.14 |
| 2010-07-04 | Scott Feldman | R | 27 | W 3-5 | vs CHA | 17 | 73 | L | 6.0 | 8 | 5 | 4 | 1 | 1 | 1 | 83 | 27 | 56 | 67% | 5-8 | 5.52 | 1.63 |
| 2010-07-05 | Omar Beltre | R | 29 | W 3-9 | vs CLE | 2 | 2 | L | 3.0 | 4 | 4 | 4 | 2 | 3 | 3 | 72 | 35 | 37 | 51% | 0-1 | 9.00 | 2.29 |
| 2010-07-06 | C.J. Wilson | L | 30 | L 12-1 | vs CLE | 17 | 23 | W | 6.0 | 2 | 1 | 1 | 1 | 2 | 4 | 102 | 43 | 59 | 58% | 7-4 | 3.25 | 1.23 |
| 2010-07-07 | Colby Lewis | R | 31 | L 4-3 | vs CLE | 17 | 51 | W | 6.0 | 6 | 3 | 2 | 1 | 2 | 8 | 102 | 36 | 66 | 65% | 8-5 | 3.32 | 1.12 |
| 2010-07-08 | Tommy Hunter | R | 24 | W 4-6 | vs BAL | 7 | 29 | - | 6.0 | 7 | 3 | 3 | 2 | 1 | 7 | 83 | 24 | 59 | 71% | 5-0 | 2.36 | 1.17 |
| 2010-07-09 | Scott Feldman | R | 27 | W 6-7 | vs BAL | 18 | 74 | - | 7.0 | 8 | 2 | 2 | 0 | 0 | 2 | 94 | 33 | 61 | 65% | 5-8 | 5.33 | 1.60 |
| 2010-07-10 | Cliff Lee | L | 32 | W 1-6 | vs BAL | 14 | 204 | L | 9.0 | 9 | 6 | 6 | 3 | 0 | 2 | 95 | 22 | 73 | 77% | 8-4 | 2.63 | 0.95 |
| 2010-07-11 | C.J. Wilson | L | 30 | W 1-4 | vs BAL | 18 | 24 | L | 4.2 | 3 | 3 | 3 | 0 | 5 | 5 | 111 | 51 | 60 | 54% | 7-5 | 3.35 | 1.25 |
| 2010-07-15 | Tommy Hunter | R | 24 | W 7-2 | @ BOS | 8 | 30 | W | 6.2 | 5 | 2 | 2 | 2 | 2 | 1 | 108 | 41 | 67 | 62% | 6-0 | 2.39 | 1.14 |
| 2010-07-16 | Colby Lewis | R | 31 | W 8-4 | @ BOS | 18 | 52 | W | 5.0 | 4 | 3 | 3 | 1 | 1 | 7 | 106 | 36 | 70 | 66% | 9-5 | 3.41 | 1.11 |
| 2010-07-17 | Cliff Lee | L | 32 | L 2-3 | @ BOS | 15 | 205 | - | 9.0 | 6 | 2 | 2 | 0 | 1 | 6 | 103 | 30 | 73 | 71% | 8-4 | 2.58 | 0.93 |
| 2010-07-18 | C.J. Wilson | L | 30 | W 4-2 | @ BOS | 19 | 25 | W | 6.2 | 3 | 1 | 1 | 0 | 5 | 10 | 112 | 51 | 61 | 54% | 8-5 | 3.23 | 1.24 |
| 2010-07-19 | Scott Feldman | R | 27 | W 8-6 | @ DET | 19 | 75 | - | 5.0 | 7 | 5 | 5 | 3 | 2 | 1 | 86 | 33 | 53 | 62% | 5-8 | 5.50 | 1.61 |
| 2010-07-20 | Tommy Hunter | R | 24 | W 8-0 | @ DET | 9 | 31 | W | 7.0 | 3 | 0 | 0 | 0 | 2 | 3 | 92 | 33 | 59 | 64% | 7-0 | 2.09 | 1.09 |
| 2010-07-21 | Colby Lewis | R | 31 | L 1-4 | @ DET | 19 | 53 | L | 7.0 | 9 | 4 | 4 | 1 | 2 | 5 | 103 | 30 | 73 | 71% | 9-6 | 3.51 | 1.14 |
| 2010-07-22 | Cliff Lee | L | 32 | L 3-2 | vs ANA | 16 | 206 | W | 8.1 | 5 | 2 | 2 | 1 | 0 | 4 | 99 | 31 | 68 | 69% | 9-4 | 2.56 | 0.92 |
| 2010-07-23 | C.J. Wilson | L | 30 | L 1-0 | vs ANA | 20 | 26 | W | 8.0 | 4 | 0 | 0 | 0 | 0 | 3 | 104 | 41 | 63 | 61% | 9-5 | 3.02 | 1.20 |
| 2010-07-24 | Scott Feldman | R | 27 | W 2-6 | vs ANA | 20 | 76 | L | 5.1 | 7 | 3 | 3 | 1 | 1 | 0 | 80 | 30 | 50 | 63% | 5-9 | 5.45 | 1.60 |
| 2010-07-25 | Tommy Hunter | R | 24 | L 6-4 | vs ANA | 10 | 32 | W | 6.1 | 3 | 3 | 3 | 2 | 1 | 1 | 71 | 23 | 48 | 68% | 8-0 | 2.32 | 1.05 |
| 2010-07-27 | Cliff Lee | L | 32 | L 3-1 | vs OAK | 17 | 207 | - | 9.0 | 5 | 1 | 0 | 0 | 0 | 13 | 117 | 30 | 87 | 74% | 9-4 | 2.40 | 0.89 |
| 2010-07-28 | Colby Lewis | R | 31 | W 1-3 | vs OAK | 20 | 54 | L | 7.0 | 5 | 1 | 1 | 1 | 2 | 8 | 114 | 42 | 72 | 63% | 9-7 | 3.39 | 1.13 |
| 2010-07-29 | C.J. Wilson | L | 30 | L 7-4 | vs OAK | 21 | 27 | W | 5.2 | 7 | 3 | 3 | 0 | 2 | 5 | 105 | 37 | 68 | 65% | 10-5 | 3.11 | 1.22 |
| 2010-07-30 | Tommy Hunter | R | 24 | L 7-9 | @ ANA | 11 | 33 | L | 3.0 | 8 | 8 | 8 | 2 | 1 | 1 | 64 | 23 | 41 | 64% | 8-1 | 3.32 | 1.14 |
| 2010-07-31 | Rich Harden | R | 29 | W 2-1 | @ ANA | 14 | 141 | W | 7.0 | 5 | 1 | 1 | 1 | 2 | 3 | 90 | 27 | 63 | 70% | 4-3 | 5.25 | 1.61 |
| 2010-08-01 | Cliff Lee | L | 32 | L 1-4 | @ ANA | 18 | 208 | L | 8.0 | 9 | 4 | 4 | 0 | 2 | 4 | 110 | 37 | 73 | 66% | 9-5 | 2.51 | 0.92 |
| 2010-08-03 | Colby Lewis | R | 31 | L 2-3 | @ SEA | 21 | 55 | L | 6.0 | 9 | 3 | 3 | 1 | 1 | 9 | 106 | 34 | 72 | 68% | 9-8 | 3.44 | 1.15 |
| 2010-08-04 | C.J. Wilson | L | 30 | W 11-6 | @ SEA | 22 | 28 | - | 3.0 | 6 | 4 | 4 | 1 | 4 | 3 | 90 | 44 | 46 | 51% | 10-5 | 3.31 | 1.26 |
| 2010-08-05 | Tommy Hunter | R | 24 | W 6-0 | @ SEA | 12 | 34 | W | 6.1 | 8 | 0 | 0 | 0 | 2 | 5 | 102 | 33 | 69 | 68% | 9-1 | 3.00 | 1.17 |
| 2010-08-06 | Cliff Lee | L | 32 | W 5-1 | @ OAK | 19 | 209 | W | 8.0 | 7 | 1 | 1 | 0 | 0 | 8 | 109 | 30 | 79 | 72% | 10-5 | 2.44 | 0.92 |
| 2010-08-07 | Rich Harden | R | 29 | L 2-6 | @ OAK | 15 | 142 | L | 2.1 | 2 | 3 | 3 | 1 | 5 | 2 | 65 | 33 | 32 | 49% | 4-4 | 5.47 | 1.66 |
| 2010-08-08 | Colby Lewis | R | 31 | L 2-3 | @ OAK | 22 | 56 | - | 6.0 | 3 | 1 | 1 | 0 | 3 | 7 | 113 | 47 | 66 | 58% | 9-8 | 3.36 | 1.15 |
| 2010-08-10 | C.J. Wilson | L | 30 | L 4-3 | vs NYA | 23 | 29 | - | 5.1 | 5 | 2 | 2 | 0 | 3 | 5 | 96 | 37 | 59 | 61% | 10-5 | 3.30 | 1.27 |
| 2010-08-11 | Cliff Lee | L | 32 | W 6-7 | vs NYA | 20 | 210 | - | 6.1 | 8 | 4 | 4 | 0 | 0 | 11 | 106 | 30 | 76 | 72% | 10-5 | 2.57 | 0.93 |
| 2010-08-13 | Tommy Hunter | R | 24 | L 10-9 | vs BOS | 13 | 35 | - | 3.0 | 6 | 4 | 4 | 4 | 0 | 0 | 50 | 18 | 32 | 64% | 9-1 | 3.36 | 1.20 |
| 2010-08-14 | Colby Lewis | R | 31 | W 1-3 | vs BOS | 23 | 57 | L | 6.2 | 6 | 1 | 1 | 0 | 2 | 9 | 117 | 44 | 73 | 62% | 9-9 | 3.28 | 1.16 |
| 2010-08-15 | C.J. Wilson | L | 30 | L 7-3 | vs BOS | 24 | 30 | W | 7.2 | 4 | 1 | 1 | 0 | 1 | 8 | 111 | 38 | 73 | 66% | 11-5 | 3.20 | 1.24 |
| 2010-08-16 | Cliff Lee | L | 32 | L 4-6 | @ TBA | 21 | 211 | L | 7.2 | 9 | 6 | 6 | 0 | 1 | 10 | 98 | 23 | 75 | 77% | 10-6 | 2.77 | 0.95 |
| 2010-08-17 | Tommy Hunter | R | 24 | L 1-10 | @ TBA | 14 | 36 | L | 3.0 | 6 | 4 | 4 | 0 | 3 | 4 | 83 | 31 | 52 | 63% | 9-2 | 3.69 | 1.27 |
| 2010-08-18 | Derek Holland | L | 24 | L 6-8 | @ TBA | 5 | 26 | L | 4.1 | 6 | 5 | 5 | 2 | 4 | 8 | 111 | 53 | 58 | 52% | 2-2 | 5.25 | 1.46 |
| 2010-08-19 | Colby Lewis | R | 31 | L 0-4 | @ BAL | 24 | 58 | L | 6.2 | 9 | 4 | 4 | 0 | 1 | 4 | 92 | 27 | 65 | 71% | 9-10 | 3.37 | 1.17 |
| 2010-08-20 | C.J. Wilson | L | 30 | W 2-0 | @ BAL | 25 | 31 | W | 8.2 | 3 | 0 | 0 | 0 | 1 | 12 | 118 | 39 | 79 | 67% | 12-5 | 3.02 | 1.20 |
| 2010-08-21 | Cliff Lee | L | 32 | L 6-8 | @ BAL | 22 | 212 | L | 5.2 | 10 | 8 | 8 | 4 | 1 | 4 | 110 | 32 | 78 | 71% | 10-7 | 3.09 | 0.98 |
| 2010-08-22 | Tommy Hunter | R | 24 | W 6-4 | @ BAL | 15 | 37 | W | 8.0 | 5 | 3 | 3 | 1 | 0 | 0 | 94 | 22 | 72 | 77% | 10-2 | 3.66 | 1.21 |
| 2010-08-23 | Rich Harden | R | 29 | L 4-0 | vs MIN | 16 | 143 | W | 6.2 | 0 | 0 | 0 | 0 | 5 | 6 | 110 | 49 | 61 | 55% | 5-4 | 5.00 | 1.58 |
| 2010-08-24 | Colby Lewis | R | 31 | L 4-3 | vs MIN | 25 | 59 | - | 6.1 | 7 | 3 | 3 | 0 | 0 | 2 | 98 | 33 | 65 | 66% | 9-10 | 3.41 | 1.17 |
| 2010-08-25 | C.J. Wilson | L | 30 | L 4-3 | vs MIN | 26 | 32 | W | 6.0 | 7 | 3 | 2 | 0 | 2 | 6 | 103 | 37 | 66 | 64% | 13-5 | 3.02 | 1.21 |
| 2010-08-26 | Cliff Lee | L | 32 | W 4-6 | vs MIN | 23 | 213 | L | 5.0 | 7 | 5 | 5 | 1 | 1 | 5 | 92 | 33 | 59 | 64% | 10-8 | 3.25 | 0.99 |
| 2010-08-27 | Tommy Hunter | R | 24 | L 7-3 | vs OAK | 16 | 38 | W | 7.2 | 7 | 3 | 3 | 2 | 2 | 4 | 101 | 35 | 66 | 65% | 11-2 | 3.68 | 1.22 |
| 2010-08-28 | Rich Harden | R | 29 | W 0-5 | vs OAK | 17 | 144 | L | 4.1 | 8 | 4 | 4 | 1 | 2 | 2 | 72 | 25 | 47 | 65% | 5-5 | 5.19 | 1.62 |
| 2010-08-29 | Colby Lewis | R | 31 | W 2-8 | vs OAK | 26 | 60 | L | 5.2 | 8 | 7 | 5 | 2 | 3 | 7 | 91 | 30 | 61 | 67% | 9-11 | 3.56 | 1.19 |
| 2010-08-30 | C.J. Wilson | L | 30 | W 3-0 | @ KCA | 27 | 33 | W | 7.2 | 2 | 0 | 0 | 0 | 4 | 6 | 110 | 48 | 62 | 56% | 14-5 | 2.88 | 1.19 |
| 2010-08-31 | Cliff Lee | L | 32 | L 9-10 | @ KCA | 24 | 214 | - | 4.2 | 10 | 7 | 4 | 1 | 0 | 5 | 108 | 38 | 70 | 65% | 10-8 | 3.38 | 1.03 |
| 2010-09-01 | Tommy Hunter | R | 24 | W 4-3 | @ KCA | 17 | 39 | W | 5.2 | 7 | 2 | 2 | 1 | 4 | 3 | 96 | 41 | 55 | 57% | 12-2 | 3.64 | 1.25 |
| 2010-09-03 | Derek Holland | L | 24 | L 3-4 | @ MIN | 6 | 27 | L | 6.1 | 6 | 4 | 4 | 0 | 1 | 5 | 91 | 27 | 64 | 70% | 2-3 | 4.89 | 1.37 |
| 2010-09-04 | Colby Lewis | R | 31 | L 4-12 | @ MIN | 27 | 61 | L | 3.2 | 8 | 9 | 9 | 2 | 2 | 2 | 77 | 30 | 47 | 61% | 9-12 | 3.95 | 1.22 |
| 2010-09-05 | C.J. Wilson | L | 30 | L 5-6 | @ MIN | 28 | 34 | L | 5.1 | 7 | 6 | 6 | 0 | 4 | 5 | 99 | 43 | 56 | 57% | 14-6 | 3.10 | 1.21 |
| 2010-09-06 | Tommy Hunter | R | 24 | L 2-7 | @ TOR | 18 | 40 | L | 7.0 | 7 | 7 | 7 | 3 | 2 | 4 | 95 | 34 | 61 | 64% | 12-3 | 3.99 | 1.25 |
| 2010-09-07 | Scott Feldman | R | 28 | L 5-8 | @ TOR | 21 | 77 | L | 4.2 | 7 | 4 | 4 | 2 | 1 | 4 | 65 | 21 | 44 | 68% | 6-10 | 5.51 | 1.60 |
| 2010-09-08 | Derek Holland | L | 24 | W 8-1 | @ TOR | 7 | 28 | W | 5.0 | 3 | 0 | 0 | 0 | 2 | 8 | 87 | 34 | 53 | 61% | 3-3 | 4.28 | 1.33 |
| 2010-09-09 | Colby Lewis | R | 31 | W 4-2 | @ TOR | 28 | 62 | W | 6.1 | 5 | 1 | 1 | 1 | 2 | 8 | 89 | 31 | 58 | 65% | 10-12 | 3.86 | 1.22 |
| 2010-09-10 | C.J. Wilson | L | 30 | L 6-5 | vs NYA | 29 | 35 | - | 3.0 | 6 | 4 | 4 | 0 | 3 | 5 | 75 | 33 | 42 | 56% | 14-6 | 3.25 | 1.24 |
| 2010-09-11 | Tommy Hunter | R | 24 | L 7-6 | vs NYA | 19 | 41 | - | 5.0 | 6 | 2 | 2 | 0 | 3 | 8 | 95 | 35 | 60 | 63% | 12-3 | 3.97 | 1.28 |
| 2010-09-12 | Cliff Lee | L | 32 | L 4-1 | vs NYA | 25 | 215 | W | 8.0 | 2 | 1 | 1 | 0 | 3 | 5 | 107 | 38 | 69 | 64% | 11-8 | 3.28 | 1.01 |
| 2010-09-14 | Derek Holland | L | 24 | L 11-4 | vs DET | 8 | 29 | - | 4.0 | 4 | 4 | 1 | 0 | 2 | 5 | 87 | 30 | 57 | 66% | 3-3 | 4.09 | 1.34 |
| 2010-09-15 | Colby Lewis | R | 31 | L 11-7 | vs DET | 29 | 63 | W | 6.0 | 4 | 5 | 2 | 0 | 3 | 3 | 96 | 35 | 61 | 64% | 11-12 | 3.84 | 1.22 |
| 2010-09-17 | C.J. Wilson | L | 30 | L 1-2 | @ SEA | 30 | 36 | L | 8.0 | 6 | 2 | 2 | 0 | 3 | 6 | 134 | 51 | 83 | 62% | 14-7 | 3.21 | 1.24 |
| 2010-09-18 | Cliff Lee | L | 32 | W 6-1 | @ SEA | 26 | 216 | W | 8.0 | 6 | 1 | 1 | 1 | 1 | 8 | 106 | 29 | 77 | 73% | 12-8 | 3.20 | 1.01 |
| 2010-09-19 | Tommy Hunter | R | 24 | L 1-2 | @ SEA | 20 | 42 | L | 6.0 | 6 | 2 | 2 | 0 | 1 | 1 | 99 | 30 | 69 | 70% | 12-4 | 3.92 | 1.27 |
| 2010-09-20 | Derek Holland | L | 24 | L 4-7 | @ ANA | 9 | 30 | L | 3.2 | 6 | 4 | 4 | 0 | 3 | 1 | 75 | 30 | 45 | 60% | 3-4 | 4.60 | 1.45 |
| 2010-09-21 | Colby Lewis | R | 31 | L 0-2 | @ ANA | 30 | 64 | L | 7.0 | 4 | 2 | 2 | 0 | 2 | 10 | 92 | 28 | 64 | 70% | 11-13 | 3.79 | 1.21 |
| 2010-09-22 | C.J. Wilson | L | 30 | W 2-1 | @ ANA | 31 | 37 | - | 6.0 | 3 | 1 | 1 | 1 | 3 | 5 | 99 | 40 | 59 | 60% | 14-7 | 3.15 | 1.23 |
| 2010-09-23 | Cliff Lee | L | 32 | L 0-5 | @ OAK | 27 | 217 | L | 5.0 | 6 | 4 | 4 | 0 | 2 | 3 | 92 | 35 | 57 | 62% | 12-9 | 3.29 | 1.02 |
| 2010-09-24 | Tommy Hunter | R | 24 | W 10-3 | @ OAK | 21 | 43 | W | 5.1 | 6 | 1 | 1 | 0 | 0 | 4 | 76 | 27 | 49 | 64% | 13-4 | 3.84 | 1.27 |
| 2010-09-25 | Derek Holland | L | 24 | W 4-3 | @ OAK | 10 | 31 | - | 5.0 | 4 | 1 | 1 | 0 | 2 | 3 | 95 | 40 | 55 | 58% | 3-4 | 4.33 | 1.42 |
| 2010-09-26 | Colby Lewis | R | 31 | W 16-9 | @ OAK | 31 | 65 | W | 6.0 | 6 | 1 | 1 | 0 | 1 | 6 | 100 | 33 | 67 | 67% | 12-13 | 3.72 | 1.20 |
| 2010-09-27 | C.J. Wilson | L | 30 | W 5-7 | vs SEA | 32 | 38 | L | 5.0 | 8 | 6 | 6 | 1 | 1 | 5 | 83 | 34 | 49 | 59% | 14-8 | 3.35 | 1.25 |
| 2010-09-28 | Scott Feldman | R | 28 | W 1-3 | vs SEA | 22 | 78 | L | 4.1 | 5 | 3 | 3 | 1 | 2 | 2 | 86 | 35 | 51 | 59% | 7-11 | 5.49 | 1.60 |
| 2010-09-29 | Rich Harden | R | 29 | L 6-5 | vs SEA | 18 | 145 | - | 4.0 | 6 | 4 | 4 | 1 | 3 | 2 | 73 | 29 | 44 | 60% | 5-5 | 5.58 | 1.66 |
| 2010-09-30 | Cliff Lee | L | 32 | L 3-2 | vs ANA | 28 | 218 | - | 7.0 | 4 | 1 | 0 | 0 | 0 | 8 | 92 | 31 | 61 | 66% | 12-9 | 3.18 | 1.00 |
| 2010-10-01 | Tommy Hunter | R | 24 | W 4-5 | vs ANA | 22 | 44 | - | 5.0 | 3 | 1 | 1 | 1 | 0 | 1 | 60 | 19 | 41 | 68% | 13-4 | 3.73 | 1.23 |
| 2010-10-02 | C.J. Wilson | L | 30 | L 6-2 | vs ANA | 33 | 39 | W | 5.0 | 4 | 2 | 2 | 0 | 2 | 4 | 81 | 35 | 46 | 57% | 15-8 | 3.35 | 1.25 |
| 2010-10-03 | Colby Lewis | R | 31 | W 2-6 | vs ANA | 32 | 66 | - | 5.0 | 1 | 2 | 2 | 1 | 2 | 4 | 66 | 20 | 46 | 70% | 12-13 | 3.72 | 1.19 |