| 36 | C.J. Wilson | - | 9 | 33 | 33 | 204.0 | 3.35 | 1.25 | 7.10 | 0.44 | 4.10 | 7.50 | 0.55 | 1.00 | 20 | 10 | 743 | .217 | 850 | 4.07 | 40.9 | 59.1 | 6.9 |
| 48 | Colby Lewis | - | 19 | 32 | 32 | 201.0 | 3.72 | 1.19 | 7.79 | 0.94 | 2.91 | 8.78 | 0.33 | 0.64 | 20 | 6 | 765 | .227 | 844 | 3.91 | 35.6 | 64.4 | 9.6 |
| 39 | Scott Feldman | - | - | 29 | 22 | 141.1 | 5.48 | 1.60 | 11.53 | 1.15 | 2.87 | 4.78 | 0.60 | 0.75 | 6 | 5 | 578 | .313 | 641 | 3.79 | 37.9 | 62.1 | 6.1 |
| 35 | Tommy Hunter | - | 94 | 23 | 22 | 128.0 | 3.73 | 1.24 | 8.86 | 1.48 | 2.32 | 4.78 | 0.49 | 0.73 | 13 | 3 | 495 | .255 | 535 | 3.53 | 34.3 | 65.7 | 5.9 |
| 33 | Cliff Lee | - | 3 | 15 | 15 | 108.2 | 3.98 | 1.06 | 8.53 | 0.91 | 0.99 | 7.95 | 0.13 | 0.74 | 0 | 0 | 0 | -- | 0 | -- | 30.4 | 69.6 | 7.7 |
| 40 | Rich Harden | - | - | 20 | 18 | 92.0 | 5.58 | 1.66 | 8.90 | 1.76 | 6.07 | 7.34 | 0.83 | 0.52 | 5 | 9 | 355 | .256 | 430 | 4.10 | 39.2 | 60.8 | 7.8 |
| 54 | Matt Harrison | - | - | 37 | 6 | 78.1 | 4.71 | 1.52 | 9.19 | 1.15 | 4.48 | 5.29 | 0.85 | 0.94 | 3 | 2 | 305 | .262 | 357 | 3.94 | 40.4 | 59.6 | 7.4 |
| 30 | Neftali Feliz | - | 29 | 70 | 0 | 69.1 | 2.73 | 0.88 | 5.58 | 0.65 | 2.34 | 9.22 | 0.25 | 0.56 | 0 | 5 | 245 | .176 | 269 | 3.98 | 35.4 | 64.6 | 12.0 |
| 56 | Darren O'Day | - | 66 | 72 | 0 | 62.0 | 2.03 | 0.89 | 6.24 | 0.73 | 1.74 | 6.53 | 0.27 | 0.65 | 0 | 5 | 219 | .196 | 240 | 3.73 | 34.3 | 65.7 | 9.8 |
| 28 | Darren Oliver | - | - | 64 | 0 | 61.2 | 2.48 | 1.10 | 7.74 | 0.58 | 2.19 | 9.49 | 0.23 | 0.98 | 0 | 2 | 219 | .242 | 244 | 4.07 | 37.1 | 62.9 | 9.7 |
| 45 | Derek Holland | - | - | 14 | 10 | 57.1 | 4.08 | 1.38 | 8.63 | 0.94 | 3.77 | 8.48 | 0.44 | 0.73 | 2 | 4 | 223 | .247 | 253 | 4.21 | 39.3 | 60.7 | 8.5 |
| 57 | Dustin Nippert | - | - | 38 | 2 | 56.2 | 4.29 | 1.68 | 9.69 | 1.11 | 5.40 | 7.46 | 0.72 | 0.52 | 0 | 5 | 220 | .277 | 262 | 4.09 | 40.6 | 59.4 | 8.3 |
| 50 | Frank Francisco | - | - | 56 | 0 | 52.2 | 3.76 | 1.27 | 8.37 | 0.85 | 3.08 | 10.25 | 0.30 | 0.67 | 0 | 1 | 198 | .247 | 221 | 3.95 | 34.2 | 65.8 | 11.5 |
| 64 | Alexi Ogando | - | - | 44 | 0 | 41.2 | 1.30 | 1.13 | 6.70 | 0.43 | 3.46 | 8.42 | 0.41 | 0.83 | 0 | 1 | 149 | .208 | 171 | 4.15 | 35.7 | 64.3 | 10.7 |
| 49 | Chris Ray | - | - | 35 | 0 | 31.2 | 3.41 | 1.26 | 6.82 | 1.14 | 4.55 | 4.55 | 1.00 | 0.60 | 0 | 0 | 0 | -- | 0 | -- | 39.9 | 60.1 | 7.9 |
| 52 | Doug Mathis | - | - | 13 | 0 | 22.1 | 6.04 | 1.84 | 12.09 | 2.82 | 4.43 | 4.03 | 1.10 | 1.08 | 0 | 0 | 89 | .337 | 100 | 3.82 | 45.0 | 55.0 | 5.2 |
| 62 | Michael Kirkman | - | - | 14 | 0 | 16.1 | 1.65 | 1.16 | 4.96 | -- | 5.51 | 8.82 | 0.63 | 1.00 | 0 | 0 | 56 | .161 | 68 | 4.09 | 42.4 | 57.6 | 7.9 |
| 46 | Pedro Strop | - | - | 15 | 0 | 10.2 | 10.12 | 2.62 | 14.34 | 1.69 | 9.28 | 9.28 | 1.00 | 0.54 | 0 | 1 | 47 | .362 | 60 | 4.07 | 40.6 | 59.4 | 11.1 |
| 59 | Clay Rapada | - | - | 13 | 0 | 9.0 | 4.00 | 1.44 | 6.00 | 2.00 | 7.00 | 5.00 | 1.40 | 0.50 | 0 | 0 | 32 | .187 | 39 | 3.77 | 44.2 | 55.8 | 6.1 |
| 68 | Omar Beltre | - | - | 2 | 2 | 7.0 | 9.00 | 2.29 | 11.57 | 3.86 | 9.00 | 11.57 | 0.78 | 0.43 | 0 | 2 | 28 | .321 | 38 | 4.13 | 45.9 | 54.1 | 9.6 |
| 49 | Mark Lowe | - | - | 3 | 0 | 3.0 | 12.00 | 2.67 | 21.00 | 3.00 | 3.00 | 15.00 | 0.20 | 0.43 | 0 | 0 | 0 | -- | 0 | -- | 40.0 | 60.0 | 11.7 |
| 58 | Guillermo Moscoso | - | - | 1 | 0 | 0.2 | 27.00 | 6.00 | 27.00 | -- | 27.00 | 27.00 | 1.00 | 0.00 | 0 | 1 | 4 | .500 | 7 | 3.71 | 46.2 | 53.8 | 7.7 |