| East | W | L | Pct | GB |
| Tampa Bay | 96 | 66 | .593 | -- |
| NY Yankees | 95 | 67 | .586 | 1.0 |
| Boston | 89 | 73 | .549 | 7.0 |
| Toronto | 85 | 77 | .525 | 11.0 |
| Baltimore | 66 | 96 | .407 | 30.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2010-04-04 | C.C. Sabathia | L | 30 | L 7-9 | @ BOS | 1 | 289 | - | 5.1 | 6 | 5 | 5 | 0 | 2 | 4 | 103 | 46 | 57 | 55% | 0-0 | 9.00 | 1.60 |
| 2010-04-06 | A.J. Burnett | R | 33 | W 6-4 | @ BOS | 1 | 245 | - | 5.0 | 7 | 4 | 3 | 1 | 1 | 5 | 100 | 38 | 62 | 62% | 0-0 | 5.40 | 1.60 |
| 2010-04-07 | Andy Pettitte | L | 38 | W 3-1 | @ BOS | 1 | 459 | - | 6.0 | 6 | 1 | 1 | 0 | 3 | 4 | 93 | 40 | 53 | 57% | 0-0 | 1.50 | 1.50 |
| 2010-04-09 | Javier Vazquez | R | 34 | L 3-9 | @ TBA | 1 | 386 | L | 5.2 | 8 | 8 | 8 | 2 | 3 | 5 | 99 | 38 | 61 | 62% | 0-1 | 12.00 | 1.83 |
| 2010-04-10 | C.C. Sabathia | L | 30 | W 10-0 | @ TBA | 2 | 290 | W | 7.2 | 1 | 0 | 0 | 0 | 2 | 5 | 116 | 46 | 70 | 60% | 1-0 | 3.46 | 0.85 |
| 2010-04-11 | A.J. Burnett | R | 33 | W 7-3 | @ TBA | 2 | 246 | W | 7.0 | 6 | 2 | 2 | 0 | 3 | 1 | 97 | 46 | 51 | 53% | 1-0 | 3.75 | 1.42 |
| 2010-04-13 | Andy Pettitte | L | 38 | L 7-5 | vs ANA | 2 | 460 | W | 6.0 | 5 | 0 | 0 | 0 | 3 | 6 | 100 | 41 | 59 | 59% | 1-0 | 0.75 | 1.42 |
| 2010-04-14 | Javier Vazquez | R | 34 | W 3-5 | vs ANA | 2 | 387 | L | 5.1 | 6 | 4 | 4 | 0 | 2 | 4 | 96 | 39 | 57 | 59% | 0-2 | 9.82 | 1.73 |
| 2010-04-15 | Philip Hughes | R | 24 | L 6-2 | vs ANA | 1 | 29 | W | 5.0 | 3 | 2 | 2 | 1 | 5 | 6 | 108 | 42 | 66 | 61% | 1-0 | 3.60 | 1.60 |
| 2010-04-16 | C.C. Sabathia | L | 30 | L 5-1 | vs TEX | 3 | 291 | W | 6.0 | 3 | 1 | 1 | 0 | 0 | 9 | 73 | 15 | 58 | 79% | 2-0 | 2.84 | 0.74 |
| 2010-04-17 | A.J. Burnett | R | 33 | L 7-3 | vs TEX | 3 | 247 | W | 7.0 | 6 | 0 | 0 | 0 | 2 | 7 | 110 | 43 | 67 | 61% | 2-0 | 2.37 | 1.32 |
| 2010-04-18 | Andy Pettitte | L | 38 | L 5-2 | vs TEX | 3 | 461 | W | 8.0 | 4 | 2 | 2 | 0 | 3 | 4 | 107 | 40 | 67 | 63% | 2-0 | 1.35 | 1.20 |
| 2010-04-20 | Javier Vazquez | R | 34 | W 7-3 | @ OAK | 3 | 388 | W | 5.1 | 6 | 3 | 3 | 2 | 3 | 6 | 105 | 35 | 70 | 67% | 1-2 | 8.44 | 1.75 |
| 2010-04-21 | Philip Hughes | R | 24 | W 3-1 | @ OAK | 2 | 30 | W | 7.1 | 1 | 1 | 1 | 0 | 2 | 10 | 100 | 31 | 69 | 69% | 2-0 | 2.25 | 0.92 |
| 2010-04-22 | C.C. Sabathia | L | 30 | L 2-4 | @ OAK | 4 | 292 | L | 8.0 | 4 | 4 | 3 | 1 | 6 | 5 | 101 | 50 | 51 | 50% | 2-1 | 3.00 | 0.89 |
| 2010-04-23 | A.J. Burnett | R | 33 | L 4-6 | @ ANA | 4 | 248 | - | 6.1 | 9 | 4 | 4 | 0 | 2 | 3 | 105 | 45 | 60 | 57% | 2-0 | 3.24 | 1.44 |
| 2010-04-24 | Andy Pettitte | L | 38 | W 7-1 | @ ANA | 4 | 462 | W | 8.0 | 6 | 1 | 1 | 0 | 0 | 8 | 114 | 39 | 75 | 66% | 3-0 | 1.29 | 1.07 |
| 2010-04-25 | Javier Vazquez | R | 34 | L 4-8 | @ ANA | 4 | 389 | L | 3.2 | 5 | 5 | 5 | 1 | 3 | 3 | 78 | 31 | 47 | 60% | 1-3 | 9.00 | 1.80 |
| 2010-04-27 | Philip Hughes | R | 24 | L 4-5 | @ BAL | 3 | 31 | - | 5.2 | 2 | 1 | 1 | 0 | 4 | 2 | 109 | 41 | 68 | 62% | 2-0 | 2.00 | 0.94 |
| 2010-04-28 | C.C. Sabathia | L | 30 | W 8-3 | @ BAL | 5 | 293 | W | 7.2 | 11 | 3 | 3 | 1 | 2 | 5 | 110 | 39 | 71 | 65% | 3-1 | 3.09 | 1.06 |
| 2010-04-29 | A.J. Burnett | R | 33 | W 4-0 | @ BAL | 5 | 249 | W | 8.0 | 3 | 0 | 0 | 0 | 1 | 4 | 119 | 40 | 79 | 66% | 3-0 | 2.45 | 1.21 |
| 2010-04-30 | Andy Pettitte | L | 38 | L 6-4 | vs CHA | 5 | 463 | - | 6.0 | 7 | 4 | 4 | 1 | 2 | 3 | 95 | 31 | 64 | 67% | 3-0 | 2.12 | 1.15 |
| 2010-05-01 | Javier Vazquez | R | 34 | W 6-7 | vs CHA | 5 | 390 | - | 3.0 | 7 | 5 | 5 | 3 | 4 | 2 | 83 | 37 | 46 | 55% | 1-3 | 9.78 | 2.04 |
| 2010-05-02 | Philip Hughes | R | 24 | L 12-3 | vs CHA | 4 | 32 | W | 7.0 | 4 | 0 | 0 | 0 | 1 | 6 | 98 | 29 | 69 | 70% | 3-0 | 1.44 | 0.88 |
| 2010-05-03 | C.C. Sabathia | L | 30 | L 4-1 | vs BAL | 6 | 294 | W | 8.0 | 6 | 1 | 1 | 1 | 2 | 2 | 106 | 39 | 67 | 63% | 4-1 | 2.72 | 1.05 |
| 2010-05-04 | A.J. Burnett | R | 33 | L 4-1 | vs BAL | 6 | 250 | W | 7.1 | 5 | 1 | 0 | 0 | 2 | 8 | 105 | 39 | 66 | 63% | 4-0 | 1.98 | 1.15 |
| 2010-05-05 | Andy Pettitte | L | 38 | L 7-5 | vs BAL | 6 | 464 | W | 5.0 | 6 | 1 | 1 | 0 | 2 | 2 | 77 | 31 | 46 | 60% | 4-0 | 2.08 | 1.21 |
| 2010-05-07 | Philip Hughes | R | 24 | W 10-3 | @ BOS | 5 | 33 | W | 7.0 | 7 | 2 | 2 | 0 | 1 | 7 | 100 | 31 | 69 | 69% | 4-0 | 1.69 | 0.94 |
| 2010-05-08 | C.C. Sabathia | L | 30 | W 14-3 | @ BOS | 7 | 295 | - | 4.2 | 4 | 3 | 3 | 2 | 2 | 4 | 85 | 35 | 50 | 59% | 4-1 | 3.06 | 1.09 |
| 2010-05-09 | A.J. Burnett | R | 33 | L 3-9 | @ BOS | 7 | 251 | L | 4.1 | 9 | 9 | 8 | 1 | 3 | 4 | 99 | 44 | 55 | 56% | 4-1 | 3.40 | 1.31 |
| 2010-05-10 | Sergio Mitre | R | 29 | L 4-5 | @ DET | 1 | 61 | L | 4.1 | 5 | 4 | 3 | 1 | 2 | 4 | 69 | 32 | 37 | 54% | 0-1 | 3.86 | 1.14 |
| 2010-05-12 | Javier Vazquez | R | 34 | L 0-2 | @ DET | 6 | 391 | L | 7.0 | 5 | 2 | 2 | 0 | 2 | 7 | 97 | 31 | 66 | 68% | 1-4 | 8.10 | 1.80 |
| 2010-05-12 | Philip Hughes | R | 24 | W 8-0 | @ DET | 6 | 34 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 8 | 101 | 30 | 71 | 70% | 5-0 | 1.38 | 0.92 |
| 2010-05-13 | C.C. Sabathia | L | 30 | L 0-6 | @ DET | 8 | 296 | L | 6.0 | 9 | 6 | 6 | 2 | 0 | 4 | 80 | 24 | 56 | 70% | 4-2 | 3.74 | 1.13 |
| 2010-05-14 | A.J. Burnett | R | 33 | L 8-4 | vs MIN | 8 | 252 | - | 6.2 | 7 | 3 | 2 | 1 | 4 | 4 | 97 | 48 | 49 | 51% | 4-1 | 3.29 | 1.35 |
| 2010-05-15 | Andy Pettitte | L | 38 | L 7-1 | vs MIN | 7 | 465 | W | 6.1 | 2 | 0 | 0 | 0 | 3 | 2 | 95 | 42 | 53 | 56% | 5-0 | 1.80 | 1.16 |
| 2010-05-16 | Sergio Mitre | R | 29 | W 3-6 | vs MIN | 2 | 62 | - | 5.0 | 4 | 1 | 1 | 1 | 1 | 3 | 79 | 35 | 44 | 56% | 0-1 | 3.32 | 1.11 |
| 2010-05-17 | Philip Hughes | R | 24 | L 11-9 | vs BOS | 7 | 35 | - | 5.0 | 6 | 5 | 5 | 2 | 1 | 3 | 104 | 33 | 71 | 68% | 5-0 | 2.25 | 0.98 |
| 2010-05-18 | C.C. Sabathia | L | 30 | W 6-7 | vs BOS | 9 | 297 | - | 7.0 | 4 | 1 | 1 | 1 | 3 | 5 | 111 | 46 | 65 | 59% | 4-2 | 3.45 | 1.12 |
| 2010-05-19 | A.J. Burnett | R | 33 | W 6-10 | vs TBA | 9 | 253 | L | 6.2 | 9 | 6 | 6 | 1 | 4 | 4 | 115 | 49 | 66 | 57% | 4-2 | 3.88 | 1.43 |
| 2010-05-20 | Andy Pettitte | L | 38 | W 6-8 | vs TBA | 8 | 466 | L | 5.0 | 9 | 7 | 6 | 3 | 2 | 3 | 103 | 38 | 65 | 63% | 5-1 | 2.70 | 1.26 |
| 2010-05-21 | Javier Vazquez | R | 34 | W 2-1 | @ NYN | 7 | 392 | W | 6.0 | 1 | 0 | 0 | 0 | 2 | 6 | 68 | 24 | 44 | 65% | 3-4 | 6.75 | 1.58 |
| 2010-05-22 | Philip Hughes | R | 24 | L 3-5 | @ NYN | 8 | 36 | L | 5.2 | 8 | 4 | 4 | 0 | 3 | 7 | 114 | 29 | 85 | 75% | 5-1 | 2.70 | 1.08 |
| 2010-05-23 | C.C. Sabathia | L | 30 | L 4-6 | @ NYN | 10 | 298 | L | 5.0 | 10 | 6 | 5 | 2 | 2 | 6 | 97 | 35 | 62 | 64% | 4-3 | 3.88 | 1.22 |
| 2010-05-25 | A.J. Burnett | R | 33 | W 1-0 | @ MIN | 10 | 254 | W | 5.0 | 3 | 0 | 0 | 0 | 2 | 5 | 82 | 33 | 49 | 60% | 5-2 | 3.57 | 1.40 |
| 2010-05-26 | Andy Pettitte | L | 38 | W 3-2 | @ MIN | 9 | 467 | W | 8.0 | 8 | 2 | 2 | 0 | 0 | 4 | 95 | 22 | 73 | 77% | 6-1 | 2.64 | 1.22 |
| 2010-05-27 | Javier Vazquez | R | 34 | L 2-8 | @ MIN | 8 | 393 | L | 5.2 | 8 | 5 | 5 | 1 | 3 | 2 | 111 | 48 | 63 | 57% | 3-5 | 6.86 | 1.62 |
| 2010-05-28 | Philip Hughes | R | 24 | L 8-2 | vs CLE | 9 | 37 | W | 7.0 | 5 | 2 | 2 | 1 | 1 | 8 | 109 | 33 | 76 | 70% | 6-1 | 2.68 | 1.05 |
| 2010-05-29 | C.C. Sabathia | L | 30 | W 11-13 | vs CLE | 11 | 299 | - | 6.0 | 7 | 5 | 5 | 0 | 2 | 5 | 112 | 35 | 77 | 69% | 4-3 | 4.18 | 1.24 |
| 2010-05-30 | A.J. Burnett | R | 33 | L 7-3 | vs CLE | 11 | 255 | W | 8.0 | 5 | 3 | 1 | 0 | 0 | 8 | 113 | 44 | 69 | 61% | 6-2 | 3.30 | 1.31 |
| 2010-05-31 | Andy Pettitte | L | 38 | L 11-2 | vs CLE | 10 | 468 | W | 7.0 | 4 | 1 | 1 | 1 | 0 | 5 | 90 | 32 | 58 | 64% | 7-1 | 2.49 | 1.15 |
| 2010-06-01 | Javier Vazquez | R | 34 | L 3-1 | vs BAL | 9 | 394 | W | 7.0 | 4 | 1 | 1 | 1 | 1 | 7 | 101 | 40 | 61 | 60% | 4-5 | 6.06 | 1.49 |
| 2010-06-02 | Philip Hughes | R | 24 | L 9-1 | vs BAL | 10 | 38 | W | 7.0 | 6 | 1 | 1 | 0 | 1 | 7 | 100 | 29 | 71 | 71% | 7-1 | 2.53 | 1.05 |
| 2010-06-03 | C.C. Sabathia | L | 30 | L 6-3 | vs BAL | 12 | 300 | W | 7.0 | 3 | 3 | 3 | 2 | 1 | 7 | 94 | 34 | 60 | 64% | 5-3 | 4.15 | 1.18 |
| 2010-06-04 | A.J. Burnett | R | 33 | L 1-6 | @ TOR | 12 | 256 | L | 6.0 | 6 | 6 | 6 | 3 | 4 | 2 | 105 | 45 | 60 | 57% | 6-3 | 3.74 | 1.34 |
| 2010-06-05 | Andy Pettitte | L | 38 | L 2-3 | @ TOR | 11 | 469 | - | 7.2 | 5 | 2 | 2 | 2 | 3 | 10 | 106 | 33 | 73 | 69% | 7-1 | 2.47 | 1.14 |
| 2010-06-06 | Javier Vazquez | R | 34 | W 4-3 | @ TOR | 10 | 395 | W | 7.0 | 1 | 2 | 2 | 1 | 4 | 9 | 108 | 43 | 65 | 60% | 5-5 | 5.63 | 1.39 |
| 2010-06-08 | Philip Hughes | R | 24 | W 12-7 | @ BAL | 11 | 39 | W | 6.0 | 9 | 3 | 3 | 0 | 0 | 4 | 101 | 32 | 69 | 68% | 8-1 | 2.70 | 1.09 |
| 2010-06-09 | C.C. Sabathia | L | 30 | W 4-2 | @ BAL | 13 | 301 | W | 7.0 | 9 | 2 | 2 | 0 | 3 | 8 | 117 | 44 | 73 | 62% | 6-3 | 4.02 | 1.22 |
| 2010-06-10 | A.J. Burnett | R | 33 | L 3-4 | @ BAL | 13 | 257 | L | 6.2 | 8 | 4 | 4 | 1 | 1 | 5 | 103 | 41 | 62 | 60% | 6-4 | 3.86 | 1.33 |
| 2010-06-11 | Andy Pettitte | L | 38 | L 4-3 | vs HOU | 12 | 470 | W | 7.1 | 4 | 3 | 2 | 0 | 1 | 4 | 98 | 30 | 68 | 69% | 8-1 | 2.48 | 1.10 |
| 2010-06-12 | Javier Vazquez | R | 34 | L 9-3 | vs HOU | 11 | 396 | W | 7.0 | 6 | 3 | 3 | 2 | 0 | 6 | 94 | 37 | 57 | 61% | 6-5 | 5.43 | 1.33 |
| 2010-06-13 | Philip Hughes | R | 24 | L 9-5 | vs HOU | 12 | 40 | W | 5.2 | 7 | 5 | 5 | 1 | 2 | 6 | 110 | 37 | 73 | 66% | 9-1 | 3.12 | 1.13 |
| 2010-06-15 | C.C. Sabathia | L | 30 | L 8-3 | vs PHI | 14 | 302 | W | 7.0 | 5 | 3 | 3 | 0 | 3 | 7 | 113 | 45 | 68 | 60% | 7-3 | 4.01 | 1.22 |
| 2010-06-16 | A.J. Burnett | R | 33 | W 3-6 | vs PHI | 14 | 258 | L | 3.1 | 6 | 6 | 6 | 2 | 4 | 3 | 87 | 39 | 48 | 55% | 6-5 | 4.34 | 1.40 |
| 2010-06-17 | Andy Pettitte | L | 38 | W 1-7 | vs PHI | 13 | 471 | L | 7.0 | 6 | 3 | 2 | 1 | 3 | 7 | 108 | 40 | 68 | 63% | 8-2 | 2.48 | 1.11 |
| 2010-06-18 | Javier Vazquez | R | 34 | W 0-4 | vs NYN | 12 | 397 | L | 7.0 | 3 | 1 | 1 | 0 | 3 | 4 | 107 | 42 | 65 | 61% | 6-6 | 5.01 | 1.29 |
| 2010-06-19 | Philip Hughes | R | 24 | L 5-3 | vs NYN | 13 | 41 | W | 7.0 | 5 | 3 | 3 | 2 | 3 | 4 | 98 | 37 | 61 | 62% | 10-1 | 3.18 | 1.13 |
| 2010-06-20 | C.C. Sabathia | L | 30 | L 4-0 | vs NYN | 15 | 303 | W | 8.0 | 4 | 0 | 0 | 0 | 2 | 6 | 100 | 34 | 66 | 66% | 8-3 | 3.69 | 1.18 |
| 2010-06-21 | A.J. Burnett | R | 33 | L 4-10 | @ ARI | 15 | 259 | L | 4.0 | 9 | 7 | 7 | 3 | 2 | 4 | 96 | 43 | 53 | 55% | 6-6 | 4.85 | 1.46 |
| 2010-06-22 | Andy Pettitte | L | 38 | W 9-3 | @ ARI | 14 | 472 | W | 7.0 | 7 | 2 | 2 | 0 | 2 | 7 | 116 | 42 | 74 | 64% | 9-2 | 2.49 | 1.13 |
| 2010-06-23 | Javier Vazquez | R | 34 | W 6-5 | @ ARI | 13 | 398 | - | 5.0 | 6 | 4 | 4 | 0 | 2 | 1 | 85 | 34 | 51 | 60% | 6-6 | 5.16 | 1.31 |
| 2010-06-25 | C.C. Sabathia | L | 30 | W 2-1 | @ LAN | 16 | 304 | W | 8.0 | 4 | 1 | 1 | 0 | 3 | 7 | 117 | 41 | 76 | 65% | 9-3 | 3.50 | 1.16 |
| 2010-06-26 | A.J. Burnett | R | 33 | L 4-9 | @ LAN | 16 | 260 | L | 3.0 | 6 | 6 | 6 | 0 | 6 | 5 | 85 | 46 | 39 | 46% | 6-7 | 5.27 | 1.54 |
| 2010-06-27 | Andy Pettitte | L | 38 | W 8-6 | @ LAN | 15 | 473 | - | 5.0 | 6 | 5 | 4 | 1 | 3 | 5 | 90 | 32 | 58 | 64% | 9-2 | 2.73 | 1.16 |
| 2010-06-29 | Philip Hughes | R | 24 | W 4-7 | vs SEA | 14 | 42 | L | 5.2 | 10 | 7 | 6 | 1 | 2 | 3 | 94 | 31 | 63 | 67% | 10-2 | 3.58 | 1.19 |
| 2010-06-30 | Javier Vazquez | R | 34 | W 0-7 | vs SEA | 14 | 399 | L | 6.0 | 6 | 3 | 3 | 2 | 2 | 8 | 113 | 42 | 71 | 63% | 6-7 | 5.11 | 1.31 |
| 2010-07-01 | C.C. Sabathia | L | 30 | L 4-2 | vs SEA | 17 | 305 | W | 8.0 | 5 | 2 | 1 | 0 | 2 | 4 | 116 | 46 | 70 | 60% | 10-3 | 3.34 | 1.14 |
| 2010-07-02 | A.J. Burnett | R | 33 | W 1-6 | vs TOR | 17 | 261 | - | 6.2 | 4 | 0 | 0 | 0 | 3 | 6 | 106 | 38 | 68 | 64% | 6-7 | 4.90 | 1.50 |
| 2010-07-03 | Andy Pettitte | L | 38 | L 11-3 | vs TOR | 16 | 474 | W | 6.0 | 5 | 3 | 3 | 2 | 1 | 4 | 97 | 35 | 62 | 64% | 10-2 | 2.83 | 1.15 |
| 2010-07-04 | Philip Hughes | R | 24 | L 7-6 | vs TOR | 15 | 43 | - | 6.0 | 6 | 5 | 5 | 3 | 2 | 5 | 101 | 35 | 66 | 65% | 10-2 | 3.83 | 1.20 |
| 2010-07-05 | Javier Vazquez | R | 34 | W 3-1 | @ OAK | 15 | 400 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 2 | 110 | 38 | 72 | 65% | 7-7 | 4.81 | 1.26 |
| 2010-07-06 | C.C. Sabathia | L | 30 | W 6-1 | @ OAK | 18 | 306 | W | 7.2 | 7 | 1 | 1 | 0 | 3 | 10 | 126 | 47 | 79 | 63% | 11-3 | 3.19 | 1.15 |
| 2010-07-07 | A.J. Burnett | R | 34 | W 6-2 | @ OAK | 18 | 262 | W | 7.0 | 5 | 2 | 2 | 0 | 2 | 3 | 113 | 46 | 67 | 59% | 7-7 | 4.75 | 1.47 |
| 2010-07-08 | Andy Pettitte | L | 38 | W 3-1 | @ SEA | 17 | 475 | W | 8.0 | 5 | 1 | 1 | 0 | 4 | 9 | 107 | 40 | 67 | 63% | 11-2 | 2.71 | 1.15 |
| 2010-07-09 | Philip Hughes | R | 24 | W 6-1 | @ SEA | 16 | 44 | W | 7.0 | 6 | 1 | 1 | 0 | 0 | 5 | 112 | 32 | 80 | 71% | 11-2 | 3.65 | 1.18 |
| 2010-07-10 | Javier Vazquez | R | 34 | L 1-4 | @ SEA | 16 | 401 | - | 7.0 | 3 | 0 | 0 | 0 | 2 | 7 | 116 | 41 | 75 | 65% | 7-7 | 4.45 | 1.22 |
| 2010-07-11 | C.C. Sabathia | L | 30 | W 8-2 | @ SEA | 19 | 307 | W | 7.0 | 6 | 1 | 1 | 0 | 1 | 1 | 95 | 35 | 60 | 63% | 12-3 | 3.09 | 1.14 |
| 2010-07-16 | C.C. Sabathia | L | 30 | L 5-4 | vs TBA | 20 | 308 | - | 7.0 | 8 | 4 | 3 | 0 | 4 | 6 | 111 | 47 | 64 | 58% | 12-3 | 3.13 | 1.17 |
| 2010-07-17 | A.J. Burnett | R | 34 | W 5-10 | vs TBA | 19 | 263 | L | 2.0 | 4 | 4 | 4 | 1 | 0 | 1 | 43 | 18 | 25 | 58% | 7-8 | 4.99 | 1.48 |
| 2010-07-18 | Andy Pettitte | L | 38 | L 9-5 | vs TBA | 18 | 476 | - | 2.1 | 6 | 3 | 3 | 1 | 2 | 3 | 60 | 23 | 37 | 62% | 11-2 | 2.87 | 1.19 |
| 2010-07-20 | Philip Hughes | R | 24 | W 2-10 | vs ANA | 17 | 45 | L | 5.0 | 9 | 6 | 6 | 2 | 3 | 2 | 97 | 41 | 56 | 58% | 11-3 | 3.99 | 1.24 |
| 2010-07-21 | Javier Vazquez | R | 34 | L 10-6 | vs ANA | 17 | 402 | W | 5.0 | 9 | 5 | 5 | 2 | 0 | 1 | 80 | 21 | 59 | 74% | 8-7 | 4.68 | 1.25 |
| 2010-07-22 | C.C. Sabathia | L | 30 | L 10-4 | vs KCA | 21 | 309 | W | 6.1 | 11 | 4 | 3 | 0 | 4 | 9 | 120 | 42 | 78 | 65% | 13-3 | 3.19 | 1.22 |
| 2010-07-23 | A.J. Burnett | R | 34 | L 7-1 | vs KCA | 20 | 264 | W | 5.0 | 4 | 0 | 0 | 0 | 1 | 3 | 58 | 22 | 36 | 62% | 8-8 | 4.77 | 1.46 |
| 2010-07-24 | Sergio Mitre | R | 29 | W 4-7 | vs KCA | 3 | 63 | L | 4.1 | 7 | 7 | 5 | 1 | 1 | 1 | 72 | 29 | 43 | 60% | 0-2 | 4.03 | 1.14 |
| 2010-07-25 | Philip Hughes | R | 24 | L 12-6 | vs KCA | 18 | 46 | W | 5.1 | 6 | 3 | 3 | 2 | 0 | 3 | 94 | 34 | 60 | 64% | 12-3 | 4.05 | 1.23 |
| 2010-07-26 | Javier Vazquez | R | 34 | W 3-2 | @ CLE | 18 | 403 | W | 7.0 | 5 | 2 | 2 | 1 | 3 | 5 | 106 | 41 | 65 | 61% | 9-7 | 4.54 | 1.24 |
| 2010-07-27 | C.C. Sabathia | L | 30 | L 1-4 | @ CLE | 22 | 310 | L | 7.0 | 9 | 4 | 2 | 0 | 3 | 5 | 123 | 44 | 79 | 64% | 13-4 | 3.16 | 1.25 |
| 2010-07-28 | A.J. Burnett | R | 34 | W 8-0 | @ CLE | 21 | 265 | W | 6.1 | 7 | 0 | 0 | 0 | 3 | 7 | 115 | 41 | 74 | 64% | 9-8 | 4.54 | 1.47 |
| 2010-07-29 | Dustin Moseley | R | 29 | W 11-4 | @ CLE | 1 | 24 | W | 6.0 | 4 | 1 | 1 | 0 | 2 | 4 | 82 | 29 | 53 | 65% | 1-0 | 3.18 | 1.00 |
| 2010-07-30 | Philip Hughes | R | 24 | L 2-3 | @ TBA | 19 | 47 | L | 6.0 | 4 | 3 | 3 | 1 | 2 | 6 | 107 | 46 | 61 | 57% | 12-4 | 4.08 | 1.22 |
| 2010-07-31 | Javier Vazquez | R | 34 | W 5-4 | @ TBA | 19 | 404 | - | 6.1 | 8 | 4 | 4 | 1 | 1 | 3 | 103 | 37 | 66 | 64% | 9-7 | 4.62 | 1.26 |
| 2010-08-01 | C.C. Sabathia | L | 30 | L 0-3 | @ TBA | 23 | 311 | L | 6.2 | 8 | 3 | 3 | 0 | 3 | 3 | 111 | 45 | 66 | 59% | 13-5 | 3.19 | 1.26 |
| 2010-08-02 | A.J. Burnett | R | 34 | W 6-8 | vs TOR | 22 | 266 | L | 4.2 | 8 | 8 | 8 | 2 | 2 | 4 | 95 | 37 | 58 | 61% | 9-9 | 4.93 | 1.49 |
| 2010-08-03 | Dustin Moseley | R | 29 | W 2-8 | vs TOR | 2 | 25 | L | 7.1 | 9 | 5 | 5 | 2 | 1 | 2 | 85 | 26 | 59 | 69% | 1-1 | 4.13 | 1.13 |
| 2010-08-04 | Philip Hughes | R | 24 | L 5-1 | vs TOR | 20 | 48 | W | 5.1 | 4 | 1 | 1 | 0 | 2 | 5 | 97 | 39 | 58 | 60% | 13-4 | 3.95 | 1.21 |
| 2010-08-06 | Javier Vazquez | R | 34 | W 3-6 | vs BOS | 20 | 405 | L | 5.1 | 6 | 6 | 3 | 2 | 4 | 5 | 109 | 43 | 66 | 61% | 9-8 | 4.61 | 1.28 |
| 2010-08-07 | C.C. Sabathia | L | 30 | L 5-2 | vs BOS | 24 | 312 | W | 8.0 | 6 | 2 | 2 | 1 | 1 | 4 | 101 | 39 | 62 | 61% | 14-5 | 3.14 | 1.24 |
| 2010-08-08 | Dustin Moseley | R | 29 | L 7-2 | vs BOS | 3 | 26 | W | 6.1 | 6 | 2 | 2 | 1 | 2 | 5 | 87 | 35 | 52 | 60% | 2-1 | 3.90 | 1.17 |
| 2010-08-09 | Philip Hughes | R | 24 | W 1-2 | vs BOS | 21 | 49 | L | 6.0 | 6 | 2 | 2 | 0 | 1 | 3 | 112 | 40 | 72 | 64% | 13-5 | 3.91 | 1.21 |
| 2010-08-10 | A.J. Burnett | R | 34 | L 3-4 | @ TEX | 23 | 267 | - | 7.0 | 6 | 3 | 3 | 1 | 2 | 4 | 118 | 48 | 70 | 59% | 9-9 | 4.87 | 1.47 |
| 2010-08-11 | Javier Vazquez | R | 34 | W 7-6 | @ TEX | 21 | 406 | - | 4.1 | 8 | 6 | 6 | 1 | 2 | 1 | 82 | 33 | 49 | 60% | 9-8 | 4.90 | 1.32 |
| 2010-08-12 | C.C. Sabathia | L | 30 | W 4-3 | @ KCA | 25 | 313 | W | 8.2 | 10 | 3 | 3 | 0 | 2 | 3 | 110 | 44 | 66 | 60% | 15-5 | 3.14 | 1.25 |
| 2010-08-13 | Dustin Moseley | R | 29 | L 3-4 | @ KCA | 4 | 27 | L | 4.1 | 8 | 4 | 4 | 1 | 3 | 1 | 96 | 43 | 53 | 55% | 2-2 | 4.37 | 1.31 |
| 2010-08-14 | Philip Hughes | R | 24 | W 8-3 | @ KCA | 22 | 50 | W | 6.0 | 9 | 3 | 3 | 1 | 1 | 0 | 99 | 28 | 71 | 72% | 14-5 | 3.93 | 1.23 |
| 2010-08-15 | A.J. Burnett | R | 34 | L 0-1 | @ KCA | 24 | 268 | L | 8.0 | 4 | 1 | 1 | 0 | 3 | 6 | 104 | 39 | 65 | 63% | 9-10 | 4.66 | 1.44 |
| 2010-08-16 | Javier Vazquez | R | 34 | W 1-3 | vs DET | 22 | 407 | L | 4.0 | 5 | 2 | 2 | 1 | 4 | 6 | 106 | 42 | 64 | 60% | 9-9 | 4.89 | 1.35 |
| 2010-08-17 | C.C. Sabathia | L | 30 | L 6-2 | vs DET | 26 | 314 | W | 7.0 | 5 | 2 | 2 | 2 | 3 | 9 | 114 | 44 | 70 | 61% | 16-5 | 3.12 | 1.24 |
| 2010-08-18 | Dustin Moseley | R | 29 | L 9-5 | vs DET | 5 | 28 | W | 5.0 | 5 | 4 | 4 | 3 | 2 | 2 | 84 | 35 | 49 | 58% | 3-2 | 4.73 | 1.33 |
| 2010-08-19 | Philip Hughes | R | 24 | L 11-5 | vs DET | 23 | 51 | W | 6.0 | 4 | 2 | 2 | 1 | 0 | 6 | 83 | 23 | 60 | 72% | 15-5 | 3.89 | 1.21 |
| 2010-08-20 | A.J. Burnett | R | 34 | W 0-6 | vs SEA | 25 | 269 | L | 7.0 | 12 | 6 | 6 | 2 | 3 | 4 | 122 | 45 | 77 | 63% | 9-11 | 4.80 | 1.47 |
| 2010-08-21 | Javier Vazquez | R | 34 | L 9-5 | vs SEA | 23 | 408 | - | 3.0 | 8 | 4 | 4 | 3 | 1 | 2 | 65 | 26 | 39 | 60% | 9-9 | 5.05 | 1.38 |
| 2010-08-22 | C.C. Sabathia | L | 30 | L 10-0 | vs SEA | 27 | 315 | W | 6.0 | 3 | 0 | 0 | 0 | 0 | 8 | 75 | 22 | 53 | 71% | 17-5 | 3.02 | 1.22 |
| 2010-08-23 | Ivan Nova | R | 24 | L 2-3 | @ TOR | 1 | 1 | - | 5.1 | 6 | 2 | 2 | 1 | 1 | 3 | 73 | 29 | 44 | 60% | 0-0 | 2.25 | 1.38 |
| 2010-08-24 | Dustin Moseley | R | 29 | W 11-5 | @ TOR | 6 | 29 | W | 6.0 | 5 | 2 | 2 | 0 | 4 | 4 | 97 | 47 | 50 | 52% | 4-2 | 4.50 | 1.35 |
| 2010-08-25 | Philip Hughes | R | 24 | L 3-6 | @ TOR | 24 | 52 | L | 3.2 | 6 | 5 | 5 | 1 | 5 | 6 | 106 | 38 | 68 | 64% | 15-6 | 4.13 | 1.26 |
| 2010-08-27 | A.J. Burnett | R | 34 | L 4-9 | @ CHA | 26 | 270 | L | 3.1 | 8 | 9 | 8 | 0 | 3 | 3 | 91 | 38 | 53 | 58% | 9-12 | 5.19 | 1.52 |
| 2010-08-28 | C.C. Sabathia | L | 30 | W 12-9 | @ CHA | 28 | 316 | W | 7.0 | 9 | 5 | 5 | 2 | 1 | 9 | 112 | 35 | 77 | 69% | 18-5 | 3.14 | 1.23 |
| 2010-08-29 | Ivan Nova | R | 24 | W 2-1 | @ CHA | 2 | 2 | W | 5.2 | 5 | 1 | 1 | 0 | 1 | 7 | 90 | 31 | 59 | 66% | 1-0 | 1.93 | 1.21 |
| 2010-08-30 | Dustin Moseley | R | 29 | L 11-5 | vs OAK | 7 | 30 | - | 4.1 | 5 | 4 | 4 | 1 | 4 | 4 | 79 | 31 | 48 | 61% | 4-2 | 4.86 | 1.42 |
| 2010-08-31 | Philip Hughes | R | 24 | L 9-3 | vs OAK | 25 | 53 | W | 5.0 | 4 | 2 | 2 | 0 | 5 | 1 | 98 | 46 | 52 | 53% | 16-6 | 4.11 | 1.28 |
| 2010-09-01 | A.J. Burnett | R | 34 | L 4-3 | vs OAK | 27 | 271 | W | 6.0 | 6 | 3 | 3 | 1 | 2 | 8 | 91 | 32 | 59 | 65% | 10-12 | 5.16 | 1.51 |
| 2010-09-02 | C.C. Sabathia | L | 30 | L 5-0 | vs OAK | 29 | 317 | W | 8.0 | 1 | 0 | 0 | 0 | 3 | 5 | 95 | 37 | 58 | 61% | 19-5 | 3.01 | 1.20 |
| 2010-09-03 | Ivan Nova | R | 24 | L 7-3 | vs TOR | 3 | 3 | - | 4.2 | 6 | 3 | 3 | 1 | 2 | 0 | 76 | 33 | 43 | 57% | 1-0 | 2.84 | 1.32 |
| 2010-09-04 | Javier Vazquez | R | 34 | L 7-5 | vs TOR | 24 | 409 | - | 4.2 | 4 | 5 | 5 | 2 | 4 | 6 | 87 | 38 | 49 | 56% | 10-9 | 5.00 | 1.35 |
| 2010-09-05 | Philip Hughes | R | 24 | W 3-7 | vs TOR | 26 | 54 | L | 6.0 | 7 | 6 | 6 | 3 | 1 | 5 | 100 | 31 | 69 | 69% | 16-7 | 4.30 | 1.28 |
| 2010-09-06 | A.J. Burnett | R | 34 | W 3-4 | vs BAL | 28 | 272 | L | 7.0 | 7 | 4 | 4 | 0 | 4 | 5 | 104 | 41 | 63 | 61% | 10-13 | 5.16 | 1.51 |
| 2010-09-07 | C.C. Sabathia | L | 30 | W 2-6 | vs BAL | 30 | 318 | L | 6.1 | 9 | 6 | 5 | 1 | 1 | 5 | 109 | 35 | 74 | 68% | 19-6 | 3.14 | 1.21 |
| 2010-09-08 | Ivan Nova | R | 24 | L 3-2 | vs BAL | 4 | 4 | - | 6.0 | 6 | 2 | 2 | 1 | 2 | 6 | 91 | 31 | 60 | 66% | 1-0 | 2.88 | 1.32 |
| 2010-09-10 | Javier Vazquez | R | 34 | L 5-6 | @ TEX | 25 | 410 | - | 5.0 | 6 | 4 | 4 | 0 | 2 | 1 | 95 | 32 | 63 | 66% | 10-9 | 5.07 | 1.36 |
| 2010-09-11 | A.J. Burnett | R | 34 | L 6-7 | @ TEX | 29 | 273 | - | 4.0 | 4 | 2 | 2 | 0 | 3 | 6 | 84 | 38 | 46 | 55% | 10-13 | 5.14 | 1.52 |
| 2010-09-12 | Dustin Moseley | R | 29 | L 1-4 | @ TEX | 8 | 31 | L | 6.2 | 5 | 4 | 4 | 0 | 2 | 1 | 102 | 44 | 58 | 57% | 4-3 | 4.89 | 1.39 |
| 2010-09-13 | C.C. Sabathia | L | 30 | L 0-1 | @ TBA | 31 | 319 | - | 8.0 | 2 | 0 | 0 | 0 | 2 | 9 | 117 | 42 | 75 | 64% | 19-6 | 3.03 | 1.18 |
| 2010-09-14 | Ivan Nova | R | 24 | W 8-7 | @ TBA | 5 | 5 | - | 4.2 | 6 | 6 | 6 | 1 | 3 | 2 | 75 | 31 | 44 | 59% | 1-0 | 4.34 | 1.45 |
| 2010-09-15 | Philip Hughes | R | 24 | L 3-4 | @ TBA | 27 | 55 | L | 6.2 | 6 | 4 | 4 | 2 | 0 | 5 | 109 | 43 | 66 | 61% | 16-8 | 4.31 | 1.25 |
| 2010-09-17 | A.J. Burnett | R | 34 | W 4-3 | @ BAL | 30 | 274 | - | 7.0 | 6 | 3 | 3 | 2 | 1 | 5 | 105 | 40 | 65 | 62% | 10-13 | 5.09 | 1.50 |
| 2010-09-18 | C.C. Sabathia | L | 30 | W 11-3 | @ BAL | 32 | 320 | W | 7.0 | 7 | 3 | 3 | 1 | 1 | 4 | 108 | 37 | 71 | 66% | 20-6 | 3.05 | 1.18 |
| 2010-09-19 | Andy Pettitte | L | 38 | L 3-4 | @ BAL | 19 | 477 | - | 6.0 | 3 | 1 | 1 | 0 | 1 | 2 | 80 | 28 | 52 | 65% | 11-2 | 2.80 | 1.16 |
| 2010-09-20 | Ivan Nova | R | 24 | L 8-6 | vs TBA | 6 | 6 | - | 5.2 | 3 | 3 | 2 | 0 | 2 | 4 | 79 | 31 | 48 | 61% | 1-0 | 4.11 | 1.34 |
| 2010-09-21 | Philip Hughes | R | 24 | L 8-3 | vs TBA | 28 | 56 | W | 6.1 | 4 | 3 | 3 | 1 | 5 | 6 | 112 | 45 | 67 | 60% | 17-8 | 4.31 | 1.26 |
| 2010-09-22 | A.J. Burnett | R | 34 | W 2-7 | vs TBA | 31 | 275 | L | 3.0 | 2 | 1 | 1 | 0 | 2 | 2 | 51 | 18 | 33 | 65% | 10-14 | 5.06 | 1.49 |
| 2010-09-23 | C.C. Sabathia | L | 30 | W 3-10 | vs TBA | 33 | 321 | L | 5.1 | 10 | 7 | 7 | 0 | 3 | 6 | 108 | 40 | 68 | 63% | 20-7 | 3.26 | 1.21 |
| 2010-09-24 | Andy Pettitte | L | 38 | W 8-10 | vs BOS | 20 | 478 | L | 3.1 | 10 | 7 | 6 | 1 | 0 | 1 | 75 | 29 | 46 | 61% | 11-3 | 3.17 | 1.22 |
| 2010-09-25 | Ivan Nova | R | 24 | W 3-7 | vs BOS | 7 | 7 | L | 4.2 | 4 | 4 | 4 | 0 | 3 | 2 | 80 | 35 | 45 | 56% | 1-1 | 4.50 | 1.35 |
| 2010-09-26 | Philip Hughes | R | 24 | L 4-3 | vs BOS | 29 | 57 | - | 6.0 | 3 | 1 | 1 | 0 | 4 | 4 | 102 | 38 | 64 | 63% | 17-8 | 4.22 | 1.26 |
| 2010-09-27 | A.J. Burnett | R | 34 | L 5-7 | @ TOR | 32 | 276 | L | 2.1 | 7 | 7 | 7 | 2 | 1 | 1 | 47 | 20 | 27 | 57% | 10-15 | 5.32 | 1.51 |
| 2010-09-28 | C.C. Sabathia | L | 30 | W 6-1 | @ TOR | 34 | 322 | W | 8.1 | 3 | 1 | 1 | 1 | 2 | 8 | 109 | 44 | 65 | 60% | 21-7 | 3.18 | 1.19 |
| 2010-09-29 | Javier Vazquez | R | 34 | L 4-8 | @ TOR | 26 | 411 | L | 4.2 | 10 | 7 | 7 | 3 | 2 | 0 | 90 | 35 | 55 | 61% | 10-10 | 5.33 | 1.40 |
| 2010-10-02 | Andy Pettitte | L | 38 | W 6-5 | @ BOS | 21 | 479 | - | 4.0 | 9 | 3 | 3 | 0 | 2 | 8 | 88 | 36 | 52 | 59% | 11-3 | 3.28 | 1.26 |
| 2010-10-02 | A.J. Burnett | R | 34 | L 6-7 | @ BOS | 33 | 277 | - | 6.0 | 6 | 4 | 2 | 1 | 2 | 5 | 113 | 50 | 63 | 56% | 10-15 | 5.25 | 1.51 |
| 2010-10-03 | Dustin Moseley | R | 29 | L 4-8 | @ BOS | 9 | 32 | L | 5.0 | 5 | 4 | 4 | 2 | 2 | 3 | 93 | 39 | 54 | 58% | 4-4 | 4.98 | 1.43 |