| 2009-04-05 | @ PHI | 1 | W 4-1 | 1-0 | 1 | 44,532 | Derek Lowe | Brett Myers | Derek Lowe | Brett Myers | | 4 | 1 | 3 |
| 2009-04-07 | @ PHI | 2 | W 4-0 | 2-0 | 1 | 44,178 | Jair Jurrjens | Jamie Moyer | Jair Jurrjens | Jamie Moyer | | 8 | 1 | 7 |
| 2009-04-08 | @ PHI | 3 | L 11-12 | 2-1 | 2 | 44,939 | Javier Vazquez | Joe Blanton | Clay Condrey | Blaine Boyer | Brad Lidge | 19 | 13 | 6 |
| 2009-04-10 | vs WAS | 4 | W 6-5 | 3-1 | 1 | 48,327 | Derek Lowe | Shairon Martis | Jorge Campillo | Joe Beimel | | 25 | 18 | 7 |
| 2009-04-11 | vs WAS | 5 | W 5-3 | 4-1 | 1 | 34,325 | Kenshin Kawakami | John Lannan | Kenshin Kawakami | John Lannan | Mike Gonzalez | 30 | 21 | 9 |
| 2009-04-12 | vs WAS | 6 | W 8-5 | 5-1 | 1 | 19,873 | Jair Jurrjens | Scott Olsen | Jair Jurrjens | Scott Olsen | Rafael Soriano | 38 | 26 | 12 |
| 2009-04-14 | vs FLO | 7 | L 1-5 | 5-2 | 1 | 16,293 | Javier Vazquez | Chris Volstad | Chris Volstad | Javier Vazquez | | 39 | 31 | 8 |
| 2009-04-15 | vs FLO | 8 | L 4-10 | 6-2 | 1 | 19,204 | Derek Lowe | Andrew Miller | Hayden Penn | Peter Moylan | | 43 | 41 | 2 |
| 2009-04-16 | vs FLO | 9 | L 2-6 | 6-3 | 1 | 21,072 | Kenshin Kawakami | Anibal Sanchez | Anibal Sanchez | Kenshin Kawakami | | 45 | 47 | -2 |
| 2009-04-17 | @ PIT | 10 | L 0-3 | 6-4 | 2 | 15,659 | Jair Jurrjens | Paul Maholm | Paul Maholm | Jair Jurrjens | Matt Capps | 45 | 50 | -5 |
| 2009-04-18 | @ PIT | 11 | L 0-10 | 6-5 | 2 | 20,755 | Jo-Jo Reyes | Ian Snell | Ian Snell | Jo-Jo Reyes | | 45 | 60 | -15 |
| 2009-04-19 | @ PIT | 12 | W 11-1 | 7-5 | 2 | 14,776 | Javier Vazquez | Zach Duke | Javier Vazquez | Zach Duke | | 56 | 61 | -5 |
| 2009-04-20 | @ WAS | 13 | L 2-3 | 7-6 | 3 | 12,473 | Derek Lowe | Jordan Zimmermann | Jordan Zimmermann | Derek Lowe | Joel Hanrahan | 58 | 64 | -6 |
| 2009-04-21 | @ WAS | 14 | L 3-4 | 7-7 | 2 | 15,439 | Kenshin Kawakami | Shairon Martis | Shairon Martis | Kenshin Kawakami | Joel Hanrahan | 61 | 68 | -7 |
| 2009-04-22 | @ WAS | 15 | W 1-0 | 8-7 | 2 | 15,567 | Jair Jurrjens | John Lannan | Mike Gonzalez | Garrett Mock | Rafael Soriano | 62 | 68 | -6 |
| 2009-04-24 | @ CIN | 16 | W 4-3 | 9-7 | 1 | 30,060 | Javier Vazquez | Edinson Volquez | Javier Vazquez | Edinson Volquez | Mike Gonzalez | 66 | 71 | -5 |
| 2009-04-25 | @ CIN | 17 | W 10-2 | 9-8 | 1 | 33,015 | Derek Lowe | Bronson Arroyo | Derek Lowe | Bronson Arroyo | | 76 | 73 | 3 |
| 2009-04-26 | @ CIN | 18 | L 2-8 | 9-9 | 2 | 29,327 | Kenshin Kawakami | Micah Owings | Micah Owings | Kenshin Kawakami | | 78 | 81 | -3 |
| 2009-04-27 | vs SLN | 19 | L 2-3 | 9-10 | 4 | 16,739 | Jair Jurrjens | Joel Pineiro | Joel Pineiro | Jair Jurrjens | Ryan Franklin | 80 | 84 | -4 |
| 2009-04-28 | vs SLN | 20 | W 2-1 | 10-10 | 3 | 18,121 | Jo-Jo Reyes | Kyle Lohse | Peter Moylan | Kyle McClellan | Mike Gonzalez | 82 | 85 | -3 |
| 2009-04-29 | vs SLN | 21 | L 3-5 | 10-11 | 3 | 19,127 | Javier Vazquez | Adam Wainwright | Adam Wainwright | Javier Vazquez | Ryan Franklin | 85 | 90 | -5 |
| 2009-05-01 | vs HOU | 22 | W 7-2 | 11-11 | 2 | 29,309 | Derek Lowe | Mike Hampton | Derek Lowe | Mike Hampton | | 92 | 92 | 0 |
| 2009-05-02 | vs HOU | 23 | L 1-5 | 11-12 | 3 | 28,203 | Jair Jurrjens | Roy Oswalt | Felipe Paulino | Buddy Carlyle | | 93 | 97 | -4 |
| 2009-05-03 | vs HOU | 24 | L 5-7 | 11-13 | 4 | 27,921 | Jo-Jo Reyes | Wandy Rodriguez | Geoff Geary | Peter Moylan | LaTroy Hawkins | 98 | 104 | -6 |
| 2009-05-04 | vs NYN | 25 | L 4-6 | 11-14 | 4 | 19,132 | Javier Vazquez | John Maine | John Maine | Javier Vazquez | Francisco Rodriguez | 102 | 110 | -8 |
| 2009-05-05 | vs NYN | 26 | L 3-4 | 11-15 | 4 | 21,049 | Kenshin Kawakami | Livan Hernandez | Livan Hernandez | Kenshin Kawakami | Francisco Rodriguez | 105 | 114 | -9 |
| 2009-05-06 | @ FLO | 27 | W 8-6 | 12-15 | 4 | 12,725 | Derek Lowe | Graham Taylor | Derek Lowe | Graham Taylor | Mike Gonzalez | 113 | 120 | -7 |
| 2009-05-07 | @ FLO | 28 | W 4-2 | 13-15 | 3 | 17,759 | Jair Jurrjens | Anibal Sanchez | Jair Jurrjens | Anibal Sanchez | Mike Gonzalez | 117 | 122 | -5 |
| 2009-05-08 | @ PHI | 29 | L 6-10 | 14-15 | 3 | 45,312 | Jo-Jo Reyes | Cole Hamels | Cole Hamels | Jo-Jo Reyes | | 123 | 132 | -9 |
| 2009-05-09 | @ PHI | 30 | W 6-2 | 15-15 | 3 | 45,339 | Javier Vazquez | Joe Blanton | Javier Vazquez | Joe Blanton | | 129 | 134 | -5 |
| 2009-05-10 | @ PHI | 31 | W 4-2 | 16-15 | 2 | 45,343 | Kenshin Kawakami | Brett Myers | Kenshin Kawakami | Jack Taschner | Rafael Soriano | 133 | 136 | -3 |
| 2009-05-11 | @ NYN | 32 | W 8-3 | 17-15 | 2 | 40,497 | Derek Lowe | Johan Santana | Derek Lowe | Johan Santana | | 141 | 139 | 2 |
| 2009-05-12 | @ NYN | 33 | L 3-4 | 17-16 | 2 | 39,408 | Jair Jurrjens | Mike Pelfrey | Francisco Rodriguez | Jeff Bennett | | 144 | 143 | 1 |
| 2009-05-13 | @ NYN | 34 | W 8-7 | 18-16 | 2 | 40,555 | Jo-Jo Reyes | Jonathon Niese | Jeff Bennett | Ken Takahashi | Mike Gonzalez | 152 | 150 | 2 |
| 2009-05-15 | vs ARI | 35 | W 4-3 | 19-16 | 2 | 32,593 | Javier Vazquez | Doug Davis | Mike Gonzalez | Tony Pena | | 156 | 153 | 3 |
| 2009-05-16 | vs ARI | 36 | L 0-12 | 19-17 | 2 | 30,162 | Kenshin Kawakami | Max Scherzer | Max Scherzer | Kenshin Kawakami | | 156 | 165 | -9 |
| 2009-05-18 | vs COL | 37 | L 1-5 | 19-18 | 2 | 15,364 | Derek Lowe | Jason Marquis | Jason Marquis | Derek Lowe | | 157 | 170 | -13 |
| 2009-05-19 | vs COL | 38 | W 8-1 | 20-18 | 2 | 16,749 | Jair Jurrjens | Jason Hammel | Jair Jurrjens | Jason Hammel | | 165 | 171 | -6 |
| 2009-05-20 | vs COL | 39 | W 12-4 | 20-19 | 2 | 19,259 | Javier Vazquez | Jorge de la Rosa | Javier Vazquez | Jorge de la Rosa | | 177 | 175 | 2 |
| 2009-05-21 | vs COL | 40 | L 0-9 | 20-20 | 2 | 25,481 | Kris Medlen | Aaron Cook | Aaron Cook | Kris Medlen | | 177 | 184 | -7 |
| 2009-05-22 | vs TOR | 41 | W 1-0 | 21-20 | 2 | 21,533 | Kenshin Kawakami | Roy Halladay | Kenshin Kawakami | Jesse Carlson | Mike Gonzalez | 178 | 184 | -6 |
| 2009-05-23 | vs TOR | 42 | W 4-3 | 22-20 | 2 | 27,377 | Derek Lowe | Casey Janssen | Derek Lowe | Casey Janssen | Rafael Soriano | 182 | 187 | -5 |
| 2009-05-24 | vs TOR | 43 | W 10-2 | 22-21 | 2 | 23,971 | Jair Jurrjens | Scott Richmond | Jeff Bennett | Shawn Camp | | 192 | 189 | 3 |
| 2009-05-25 | @ SFN | 44 | L 2-8 | 22-22 | 3 | 40,034 | Javier Vazquez | Jonathan Sanchez | Jonathan Sanchez | Javier Vazquez | | 194 | 197 | -3 |
| 2009-05-26 | @ SFN | 45 | L 0-4 | 22-23 | 3 | 29,485 | Kris Medlen | Tim Lincecum | Tim Lincecum | Kris Medlen | | 194 | 201 | -7 |
| 2009-05-27 | @ SFN | 46 | L 3-6 | 22-24 | 3 | 27,744 | Kenshin Kawakami | Randy Johnson | Randy Johnson | Kenshin Kawakami | Brian Wilson | 197 | 207 | -10 |
| 2009-05-28 | @ ARI | 47 | L 2-5 | 22-25 | 3 | 19,452 | Derek Lowe | Dan Haren | Dan Haren | Derek Lowe | Chad Qualls | 199 | 212 | -13 |
| 2009-05-29 | @ ARI | 48 | W 10-6 | 22-26 | 3 | 26,146 | Jair Jurrjens | Jon Garland | Jair Jurrjens | Jon Garland | | 209 | 218 | -9 |
| 2009-05-30 | @ ARI | 49 | L 2-3 | 22-27 | 4 | 35,039 | Javier Vazquez | Doug Davis | Tony Pena | Jeff Bennett | | 211 | 221 | -10 |
| 2009-05-31 | @ ARI | 50 | W 9-3 | 23-27 | 4 | 30,020 | Kris Medlen | Max Scherzer | Kris Medlen | Max Scherzer | | 220 | 224 | -4 |
| 2009-06-02 | vs CHN | 51 | W 6-5 | 24-27 | 4 | 30,262 | Kenshin Kawakami | Randy Wells | Rafael Soriano | Aaron Heilman | | 226 | 229 | -3 |
| 2009-06-03 | vs CHN | 52 | L 2-3 | 24-28 | 4 | 30,646 | Derek Lowe | Ted Lilly | Angel Guzman | Jeff Bennett | Kevin Gregg | 228 | 232 | -4 |
| 2009-06-05 | vs MIL | 53 | L 0-4 | 24-29 | 4 | 23,327 | Jair Jurrjens | Yovani Gallardo | Yovani Gallardo | Jair Jurrjens | | 228 | 236 | -8 |
| 2009-06-06 | vs MIL | 54 | L 0-3 | 24-30 | 4 | 32,721 | Javier Vazquez | Jeff Suppan | Jeff Suppan | Javier Vazquez | Trevor Hoffman | 228 | 239 | -11 |
| 2009-06-07 | vs MIL | 55 | W 8-7 | 25-30 | 4 | 33,428 | Tommy Hanson | Manny Parra | Eric O'Flaherty | Carlos Villanueva | Mike Gonzalez | 236 | 246 | -10 |
| 2009-06-08 | vs PIT | 56 | W 7-6 | 26-30 | 4 | 21,856 | Kenshin Kawakami | Zach Duke | Kris Medlen | Jeff Karstens | | 243 | 252 | -9 |
| 2009-06-09 | vs PIT | 57 | W 4-3 | 27-30 | 4 | 20,124 | Derek Lowe | Ross Ohlendorf | Derek Lowe | Sean Burnett | Rafael Soriano | 247 | 255 | -8 |
| 2009-06-10 | vs PIT | 58 | L 2-3 | 27-31 | 4 | 21,610 | Jair Jurrjens | Charlie Morton | Jeff Karstens | Jair Jurrjens | Matt Capps | 249 | 258 | -9 |
| 2009-06-11 | vs PIT | 59 | L 1-3 | 27-32 | 4 | 29,331 | Javier Vazquez | Paul Maholm | Steven Jackson | Rafael Soriano | Matt Capps | 250 | 261 | -11 |
| 2009-06-12 | @ BAL | 60 | W 7-2 | 28-32 | 4 | 28,469 | Tommy Hanson | Jason Berken | Tommy Hanson | Jason Berken | | 257 | 263 | -6 |
| 2009-06-13 | @ BAL | 61 | L 4-8 | 28-33 | 4 | 29,645 | Kenshin Kawakami | Rich Hill | Brian Bass | Eric O'Flaherty | | 261 | 271 | -10 |
| 2009-06-14 | @ BAL | 62 | L 2-11 | 29-33 | 4 | 26,770 | Derek Lowe | Brad Bergesen | Brad Bergesen | Derek Lowe | | 263 | 282 | -19 |
| 2009-06-16 | @ CIN | 63 | L 2-7 | 29-34 | 4 | 19,127 | Jair Jurrjens | Aaron Harang | Danny Herrera | Jair Jurrjens | | 265 | 289 | -24 |
| 2009-06-17 | @ CIN | 64 | L 3-4 | 29-35 | 4 | 27,455 | Javier Vazquez | Micah Owings | Micah Owings | Javier Vazquez | Francisco Cordero | 268 | 293 | -25 |
| 2009-06-18 | @ CIN | 65 | W 7-0 | 30-35 | 4 | 24,657 | Tommy Hanson | Matt Maloney | Tommy Hanson | Matt Maloney | | 275 | 293 | -18 |
| 2009-06-19 | @ BOS | 66 | W 8-2 | 31-35 | 3 | 37,703 | Kenshin Kawakami | Daisuke Matsuzaka | Kenshin Kawakami | Daisuke Matsuzaka | | 283 | 295 | -12 |
| 2009-06-20 | @ BOS | 67 | L 0-3 | 31-36 | 3 | 38,029 | Derek Lowe | Josh Beckett | Josh Beckett | Derek Lowe | | 283 | 298 | -15 |
| 2009-06-21 | @ BOS | 68 | L 5-6 | 31-37 | 3 | 37,243 | Jair Jurrjens | Tim Wakefield | Jonathan Papelbon | Jeff Bennett | | 288 | 304 | -16 |
| 2009-06-22 | vs CHN | 69 | W 2-0 | 32-37 | 3 | 31,701 | Javier Vazquez | Ryan Dempster | Javier Vazquez | Ryan Dempster | Rafael Soriano | 290 | 304 | -14 |
| 2009-06-23 | vs NYA | 70 | W 4-0 | 33-37 | 3 | 40,828 | Tommy Hanson | Chien-Ming Wang | Tommy Hanson | Chien-Ming Wang | | 294 | 304 | -10 |
| 2009-06-24 | vs NYA | 71 | L 4-8 | 33-38 | 3 | 42,315 | Kenshin Kawakami | Joba Chamberlain | Joba Chamberlain | Kris Medlen | Mariano Rivera | 298 | 312 | -14 |
| 2009-06-25 | vs NYA | 72 | L 7-11 | 34-38 | 3 | 47,508 | Derek Lowe | Andy Pettitte | Alfredo Aceves | Derek Lowe | Mariano Rivera | 305 | 323 | -18 |
| 2009-06-26 | vs BOS | 73 | L 1-4 | 34-39 | 3 | 48,418 | Jair Jurrjens | Josh Beckett | Josh Beckett | Jair Jurrjens | | 306 | 327 | -21 |
| 2009-06-27 | vs BOS | 74 | L 0-1 | 34-40 | 3 | 48,151 | Javier Vazquez | Tim Wakefield | Tim Wakefield | Javier Vazquez | Jonathan Papelbon | 306 | 328 | -22 |
| 2009-06-28 | vs BOS | 75 | W 2-1 | 35-40 | 3 | 41,463 | Tommy Hanson | Brad Penny | Tommy Hanson | Brad Penny | Mike Gonzalez | 308 | 329 | -21 |
| 2009-06-30 | vs PHI | 76 | W 5-4 | 36-40 | 3 | 31,818 | Derek Lowe | Joe Blanton | Peter Moylan | Chan Ho Park | | 313 | 333 | -20 |
| 2009-07-01 | vs PHI | 77 | W 11-1 | 37-40 | 3 | 25,212 | Jair Jurrjens | Cole Hamels | Jair Jurrjens | Cole Hamels | | 324 | 334 | -10 |
| 2009-07-02 | vs PHI | 78 | W 5-2 | 38-40 | 3 | 38,254 | Javier Vazquez | J.A. Happ | Mike Gonzalez | Ryan Madson | Rafael Soriano | 329 | 336 | -7 |
| 2009-07-03 | @ WAS | 79 | W 9-8 | 39-40 | 3 | 33,982 | Kenshin Kawakami | Ross Detwiler | Boone Logan | Jesus Colome | Rafael Soriano | 338 | 344 | -6 |
| 2009-07-04 | @ WAS | 80 | L 3-5 | 39-41 | 3 | 23,708 | Tommy Hanson | John Lannan | John Lannan | Mike Gonzalez | Mike MacDougal | 341 | 349 | -8 |
| 2009-07-05 | @ WAS | 81 | L 3-5 | 39-42 | 3 | 22,677 | Derek Lowe | Scott Olsen | Scott Olsen | Derek Lowe | Mike MacDougal | 344 | 354 | -10 |
| 2009-07-06 | @ CHN | 82 | L 2-4 | 39-43 | 3 | 40,042 | Jair Jurrjens | Randy Wells | Randy Wells | Jair Jurrjens | Kevin Gregg | 346 | 358 | -12 |
| 2009-07-07 | @ CHN | 83 | W 2-1 | 40-43 | 3 | 40,359 | Javier Vazquez | Carlos Zambrano | Javier Vazquez | Carlos Zambrano | Rafael Soriano | 348 | 359 | -11 |
| 2009-07-08 | @ CHN | 84 | W 4-1 | 41-43 | 3 | 40,531 | Kenshin Kawakami | Kevin Hart | Kenshin Kawakami | Kevin Hart | Rafael Soriano | 352 | 360 | -8 |
| 2009-07-09 | @ COL | 85 | L 6-7 | 41-44 | 3 | 30,392 | Tommy Hanson | Aaron Cook | Juan Rincon | Mike Gonzalez | Huston Street | 358 | 367 | -9 |
| 2009-07-10 | @ COL | 86 | W 4-1 | 42-44 | 3 | 35,238 | Derek Lowe | Ubaldo Jimenez | Derek Lowe | Ubaldo Jimenez | Rafael Soriano | 362 | 368 | -6 |
| 2009-07-11 | @ COL | 87 | W 4-3 | 43-44 | 3 | 38,065 | Jair Jurrjens | Jason Marquis | Jair Jurrjens | Jason Marquis | Rafael Soriano | 366 | 371 | -5 |
| 2009-07-12 | @ COL | 88 | L 7-8 | 43-45 | 4 | 33,825 | Kris Medlen | Jason Hammel | Huston Street | Luis Valdez | | 373 | 379 | -6 |
| 2009-07-16 | vs NYN | 89 | W 5-3 | 44-45 | 4 | 32,736 | Derek Lowe | Oliver Perez | Manny Acosta | Pedro Feliciano | Rafael Soriano | 378 | 382 | -4 |
| 2009-07-17 | vs NYN | 90 | W 11-0 | 45-45 | 3 | 50,704 | Jair Jurrjens | Mike Pelfrey | Jair Jurrjens | Mike Pelfrey | | 389 | 382 | 7 |
| 2009-07-18 | vs NYN | 91 | L 1-5 | 45-46 | 4 | 51,175 | Kenshin Kawakami | Johan Santana | Johan Santana | Kenshin Kawakami | | 390 | 387 | 3 |
| 2009-07-19 | vs NYN | 92 | W 7-1 | 46-46 | 3 | 34,293 | Javier Vazquez | Fernando Nieve | Javier Vazquez | Tim Redding | | 397 | 388 | 9 |
| 2009-07-20 | vs SFN | 93 | W 11-3 | 46-47 | 4 | 21,988 | Tommy Hanson | Jonathan Sanchez | Tommy Hanson | Sergio Romo | | 408 | 391 | 17 |
| 2009-07-21 | vs SFN | 94 | W 8-1 | 47-47 | 4 | 25,135 | Derek Lowe | Ryan Sadowski | Derek Lowe | Ryan Sadowski | | 416 | 392 | 24 |
| 2009-07-22 | vs SFN | 95 | W 4-2 | 48-47 | 4 | 34,672 | Jair Jurrjens | Tim Lincecum | Jair Jurrjens | Tim Lincecum | Rafael Soriano | 420 | 394 | 26 |
| 2009-07-23 | vs SFN | 96 | L 1-5 | 48-48 | 4 | 31,727 | Kenshin Kawakami | Barry Zito | Barry Zito | Mike Gonzalez | | 421 | 399 | 22 |
| 2009-07-24 | @ MIL | 97 | W 9-4 | 49-48 | 4 | 41,941 | Javier Vazquez | Manny Parra | Javier Vazquez | Carlos Villanueva | | 430 | 403 | 27 |
| 2009-07-25 | @ MIL | 98 | L 0-4 | 49-49 | 4 | 43,565 | Tommy Hanson | Yovani Gallardo | Yovani Gallardo | Tommy Hanson | | 430 | 407 | 23 |
| 2009-07-26 | @ MIL | 99 | W 10-2 | 49-50 | 4 | 43,471 | Derek Lowe | Braden Looper | Derek Lowe | Braden Looper | | 440 | 409 | 31 |
| 2009-07-28 | @ FLO | 100 | L 3-4 | 49-51 | 4 | 13,128 | Jair Jurrjens | Ricky Nolasco | Leo Nunez | Rafael Soriano | | 443 | 413 | 30 |
| 2009-07-29 | @ FLO | 101 | L 3-6 | 49-52 | 4 | 13,518 | Kenshin Kawakami | Josh Johnson | Josh Johnson | Kenshin Kawakami | Leo Nunez | 446 | 419 | 27 |
| 2009-07-30 | @ FLO | 102 | W 6-3 | 50-52 | 5 | 14,226 | Javier Vazquez | Rick Vanden Hurk | Peter Moylan | Luis Ayala | Rafael Soriano | 452 | 422 | 30 |
| 2009-07-31 | vs LAN | 103 | L 0-5 | 50-53 | 4 | 45,225 | Tommy Hanson | Jason Schmidt | Jason Schmidt | Tommy Hanson | | 452 | 427 | 25 |
| 2009-08-01 | vs LAN | 104 | W 4-3 | 51-53 | 4 | 49,843 | Derek Lowe | Randy Wolf | Derek Lowe | Randy Wolf | Rafael Soriano | 456 | 430 | 26 |
| 2009-08-02 | vs LAN | 105 | L 1-9 | 51-54 | 4 | 37,654 | Jair Jurrjens | Chad Billingsley | Chad Billingsley | Jair Jurrjens | | 457 | 439 | 18 |
| 2009-08-03 | @ SDN | 106 | L 2-4 | 51-55 | 4 | 20,423 | Kenshin Kawakami | Mat Latos | Mat Latos | Kenshin Kawakami | Heath Bell | 459 | 443 | 16 |
| 2009-08-04 | @ SDN | 107 | W 9-2 | 52-55 | 4 | 17,916 | Javier Vazquez | Tim Stauffer | Javier Vazquez | Tim Stauffer | | 468 | 445 | 23 |
| 2009-08-05 | @ SDN | 108 | W 6-2 | 53-55 | 4 | 21,816 | Tommy Hanson | Chad Gaudin | Tommy Hanson | Chad Gaudin | | 474 | 447 | 27 |
| 2009-08-06 | @ LAN | 109 | L 4-5 | 53-56 | 4 | 46,399 | Derek Lowe | Randy Wolf | Scott Elbert | Rafael Soriano | | 478 | 452 | 26 |
| 2009-08-07 | @ LAN | 110 | W 9-5 | 54-56 | 4 | 53,184 | Jair Jurrjens | Chad Billingsley | Peter Moylan | Ramon Troncoso | | 487 | 457 | 30 |
| 2009-08-08 | @ LAN | 111 | W 2-1 | 55-56 | 4 | 53,338 | Kenshin Kawakami | Clayton Kershaw | Kris Medlen | Guillermo Mota | Rafael Soriano | 489 | 458 | 31 |
| 2009-08-09 | @ LAN | 112 | W 8-2 | 56-56 | 4 | 45,438 | Javier Vazquez | Eric Stults | Javier Vazquez | Eric Stults | | 497 | 460 | 37 |
| 2009-08-11 | vs WAS | 113 | W 8-1 | 57-56 | 4 | 19,273 | Tommy Hanson | John Lannan | Tommy Hanson | John Lannan | | 505 | 461 | 44 |
| 2009-08-12 | vs WAS | 114 | W 6-2 | 58-56 | 4 | 17,886 | Derek Lowe | Craig Stammen | Derek Lowe | Jorge Sosa | | 511 | 463 | 48 |
| 2009-08-14 | vs PHI | 115 | L 2-3 | 58-57 | 4 | 37,639 | Jair Jurrjens | Joe Blanton | Ryan Madson | Rafael Soriano | Brad Lidge | 513 | 466 | 47 |
| 2009-08-15 | vs PHI | 116 | W 4-3 | 59-57 | 4 | 44,043 | Kenshin Kawakami | Cole Hamels | Peter Moylan | Brad Lidge | | 517 | 469 | 48 |
| 2009-08-16 | vs PHI | 117 | L 1-4 | 59-58 | 5 | 25,215 | Javier Vazquez | J.A. Happ | J.A. Happ | Javier Vazquez | Brad Lidge | 518 | 473 | 45 |
| 2009-08-17 | vs ARI | 118 | W 9-4 | 60-58 | 4 | 23,668 | Tommy Hanson | Max Scherzer | Tommy Hanson | Max Scherzer | | 527 | 477 | 50 |
| 2009-08-18 | @ NYN | 119 | L 4-9 | 60-59 | 4 | 38,613 | Derek Lowe | Oliver Perez | Oliver Perez | Derek Lowe | | 531 | 486 | 45 |
| 2009-08-19 | @ NYN | 120 | W 15-2 | 60-60 | 4 | 38,602 | Jair Jurrjens | Bobby Parnell | Jair Jurrjens | Bobby Parnell | | 546 | 488 | 58 |
| 2009-08-20 | @ NYN | 121 | W 3-2 | 61-60 | 4 | 39,105 | Kenshin Kawakami | Johan Santana | Kenshin Kawakami | Johan Santana | Rafael Soriano | 549 | 490 | 59 |
| 2009-08-21 | vs FLO | 122 | L 3-5 | 61-61 | 4 | 22,608 | Javier Vazquez | Anibal Sanchez | Anibal Sanchez | Javier Vazquez | Leo Nunez | 552 | 495 | 57 |
| 2009-08-22 | vs FLO | 123 | W 4-3 | 62-61 | 4 | 35,200 | Tommy Hanson | Chris Volstad | Tommy Hanson | Chris Volstad | Rafael Soriano | 556 | 498 | 58 |
| 2009-08-23 | vs FLO | 124 | W 7-5 | 63-61 | 4 | 30,478 | Derek Lowe | Ricky Nolasco | Peter Moylan | Kiko Calero | Rafael Soriano | 563 | 503 | 60 |
| 2009-08-25 | vs SDN | 125 | L 1-2 | 63-62 | 4 | 15,389 | Jair Jurrjens | Mat Latos | Joe Thatcher | Kris Medlen | Edward Mujica | 564 | 505 | 59 |
| 2009-08-26 | vs SDN | 126 | L 5-12 | 64-62 | 3 | 15,619 | Kenshin Kawakami | Tim Stauffer | Tim Stauffer | Kenshin Kawakami | | 569 | 517 | 52 |
| 2009-08-27 | vs SDN | 127 | W 9-1 | 65-62 | 3 | 18,651 | Javier Vazquez | Clayton Richard | Javier Vazquez | Clayton Richard | | 578 | 518 | 60 |
| 2009-08-28 | @ PHI | 128 | L 2-4 | 65-63 | 3 | 44,747 | Tommy Hanson | Pedro Martinez | Jamie Moyer | Tommy Hanson | Brad Lidge | 580 | 522 | 58 |
| 2009-08-29 | @ PHI | 129 | W 9-1 | 66-63 | 3 | 45,134 | Derek Lowe | Cliff Lee | Derek Lowe | Cliff Lee | | 589 | 523 | 66 |
| 2009-08-30 | @ PHI | 130 | L 2-3 | 66-64 | 3 | 44,828 | Jair Jurrjens | Joe Blanton | Joe Blanton | Jair Jurrjens | Brad Lidge | 591 | 526 | 65 |
| 2009-08-31 | @ FLO | 131 | W 5-2 | 67-64 | 3 | 12,244 | Kenshin Kawakami | Josh Johnson | Kenshin Kawakami | Josh Johnson | | 596 | 528 | 68 |
| 2009-09-01 | @ FLO | 132 | W 4-3 | 68-64 | 3 | 14,024 | Tim Hudson | Anibal Sanchez | Tim Hudson | Anibal Sanchez | Rafael Soriano | 600 | 531 | 69 |
| 2009-09-02 | @ FLO | 133 | L 7-8 | 68-65 | 3 | 14,723 | Javier Vazquez | Rick Vanden Hurk | Leo Nunez | Mike Gonzalez | | 607 | 539 | 68 |
| 2009-09-03 | @ FLO | 134 | L 3-8 | 68-66 | 3 | 13,711 | Tommy Hanson | Ricky Nolasco | Ricky Nolasco | Kris Medlen | | 610 | 547 | 63 |
| 2009-09-04 | vs CIN | 135 | L 1-3 | 68-67 | 3 | 24,219 | Derek Lowe | Bronson Arroyo | Bronson Arroyo | Derek Lowe | Francisco Cordero | 611 | 550 | 61 |
| 2009-09-05 | vs CIN | 136 | L 1-3 | 68-68 | 3 | 29,078 | Jair Jurrjens | Kip Wells | Kip Wells | Jair Jurrjens | Francisco Cordero | 612 | 553 | 59 |
| 2009-09-06 | vs CIN | 137 | L 2-4 | 68-69 | 4 | 32,397 | Tim Hudson | Johnny Cueto | Micah Owings | Kenshin Kawakami | Francisco Cordero | 614 | 557 | 57 |
| 2009-09-08 | @ HOU | 138 | W 2-1 | 69-69 | 3 | 26,081 | Javier Vazquez | Felipe Paulino | Javier Vazquez | Felipe Paulino | Rafael Soriano | 616 | 558 | 58 |
| 2009-09-09 | @ HOU | 139 | L 1-2 | 69-70 | 3 | 22,392 | Tommy Hanson | Wandy Rodriguez | Jose Valverde | Rafael Soriano | | 617 | 560 | 57 |
| 2009-09-10 | @ HOU | 140 | W 9-7 | 70-70 | 3 | 26,552 | Derek Lowe | Roy Oswalt | Derek Lowe | Roy Oswalt | Mike Gonzalez | 626 | 567 | 59 |
| 2009-09-11 | @ SLN | 141 | W 1-0 | 71-70 | 3 | 43,984 | Jair Jurrjens | Joel Pineiro | Jair Jurrjens | Joel Pineiro | Rafael Soriano | 627 | 567 | 60 |
| 2009-09-12 | @ SLN | 142 | W 7-6 | 72-70 | 3 | 43,869 | Tim Hudson | Kyle Lohse | Mike Gonzalez | Ryan Franklin | Rafael Soriano | 634 | 573 | 61 |
| 2009-09-13 | @ SLN | 143 | W 9-2 | 73-70 | 4 | 41,179 | Javier Vazquez | Chris Carpenter | Javier Vazquez | Chris Carpenter | | 643 | 575 | 68 |
| 2009-09-15 | vs NYN | 144 | W 6-0 | 74-70 | 3 | 25,094 | Tommy Hanson | Pat Misch | Tommy Hanson | Pat Misch | | 649 | 575 | 74 |
| 2009-09-16 | vs NYN | 145 | W 6-5 | 75-70 | 3 | 17,988 | Derek Lowe | Bobby Parnell | Eric O'Flaherty | Francisco Rodriguez | | 655 | 580 | 75 |
| 2009-09-17 | vs NYN | 146 | W 7-3 | 76-70 | 3 | 20,192 | Jair Jurrjens | Nelson Figueroa | Jair Jurrjens | Nelson Figueroa | | 662 | 583 | 79 |
| 2009-09-18 | vs PHI | 147 | L 4-9 | 76-71 | 3 | 27,241 | Tim Hudson | J.A. Happ | Kyle Kendrick | Tim Hudson | | 666 | 592 | 74 |
| 2009-09-19 | vs PHI | 148 | W 6-4 | 77-71 | 3 | 35,818 | Javier Vazquez | Pedro Martinez | Javier Vazquez | Pedro Martinez | | 672 | 596 | 76 |
| 2009-09-20 | vs PHI | 149 | L 2-4 | 77-72 | 3 | 29,452 | Tommy Hanson | Cliff Lee | Tyler Walker | Tommy Hanson | Brad Lidge | 674 | 600 | 74 |
| 2009-09-21 | @ NYN | 150 | W 11-3 | 77-73 | 3 | 37,706 | Derek Lowe | Pat Misch | Derek Lowe | Pat Misch | Kenshin Kawakami | 685 | 603 | 82 |
| 2009-09-22 | @ NYN | 151 | W 3-1 | 78-73 | 5 | 37,823 | Jair Jurrjens | Nelson Figueroa | Jair Jurrjens | Nelson Figueroa | Rafael Soriano | 688 | 604 | 84 |
| 2009-09-23 | @ NYN | 152 | W 5-2 | 79-73 | 3 | 38,266 | Tim Hudson | Mike Pelfrey | Tim Hudson | Mike Pelfrey | Rafael Soriano | 693 | 606 | 87 |
| 2009-09-25 | @ WAS | 153 | W 4-1 | 80-73 | 3 | 28,276 | Javier Vazquez | John Lannan | Javier Vazquez | John Lannan | | 697 | 607 | 90 |
| 2009-09-26 | @ WAS | 154 | W 11-5 | 80-74 | 3 | 29,058 | Tommy Hanson | Garrett Mock | Tommy Hanson | Garrett Mock | | 708 | 612 | 96 |
| 2009-09-27 | @ WAS | 155 | W 6-3 | 81-74 | 3 | 27,840 | Derek Lowe | Livan Hernandez | Mike Gonzalez | Mike MacDougal | Rafael Soriano | 714 | 615 | 99 |
| 2009-09-28 | vs FLO | 156 | W 4-0 | 82-74 | 3 | 25,046 | Jair Jurrjens | Anibal Sanchez | Jair Jurrjens | Anibal Sanchez | | 718 | 615 | 103 |
| 2009-09-29 | vs FLO | 157 | L 4-5 | 82-75 | 3 | 28,669 | Tim Hudson | Josh Johnson | Renyel Pinto | Kenshin Kawakami | Leo Nunez | 722 | 620 | 102 |
| 2009-09-30 | vs FLO | 158 | L 4-5 | 82-76 | 3 | 31,513 | Javier Vazquez | Ricky Nolasco | Ricky Nolasco | Javier Vazquez | Brendan Donnelly | 726 | 625 | 101 |
| 2009-10-01 | vs WAS | 159 | L 1-2 | 82-77 | 3 | 38,237 | Tommy Hanson | Garrett Mock | Tyler Clippard | Rafael Soriano | Mike MacDougal | 727 | 627 | 100 |
| 2009-10-02 | vs WAS | 160 | L 3-6 | 82-78 | 3 | 33,124 | Derek Lowe | Livan Hernandez | Livan Hernandez | Derek Lowe | Mike MacDougal | 730 | 633 | 97 |
| 2009-10-03 | vs WAS | 161 | L 4-6 | 82-79 | 3 | 28,278 | Jair Jurrjens | Ross Detwiler | Zack Segovia | Manny Acosta | Logan Kensing | 734 | 639 | 95 |
| 2009-10-04 | vs WAS | 162 | L 1-2 | 82-80 | 3 | 36,307 | Tim Hudson | J.D. Martin | Logan Kensing | Boone Logan | | 735 | 641 | 94 |