| 2009-04-06 | vs CLE | 1 | W 9-1 | 1-0 | 3 | 49,916 | Kevin Millwood | Cliff Lee | Kevin Millwood | Cliff Lee | | 9 | 1 | 8 |
| 2009-04-08 | vs CLE | 2 | W 8-5 | 2-0 | 1 | 22,829 | Vicente Padilla | Fausto Carmona | Vicente Padilla | Fausto Carmona | Frank Francisco | 17 | 6 | 11 |
| 2009-04-09 | vs CLE | 3 | W 12-8 | 2-1 | 1 | 14,672 | Brandon McCarthy | Carl Pavano | Brandon McCarthy | Carl Pavano | | 29 | 14 | 15 |
| 2009-04-10 | @ DET | 4 | L 2-15 | 3-1 | 1 | 44,588 | Kris Benson | Armando Galarraga | Armando Galarraga | Kris Benson | | 31 | 29 | 2 |
| 2009-04-11 | @ DET | 5 | L 3-4 | 3-2 | 2 | 28,693 | Matt Harrison | Justin Verlander | Nate Robertson | Matt Harrison | Fernando Rodney | 34 | 33 | 1 |
| 2009-04-12 | @ DET | 6 | L 4-6 | 3-3 | 3 | 18,905 | Kevin Millwood | Edwin Jackson | Brandon Lyon | C.J. Wilson | Fernando Rodney | 38 | 39 | -1 |
| 2009-04-13 | vs BAL | 7 | L 9-10 | 4-3 | 2 | 12,184 | Vicente Padilla | Koji Uehara | Koji Uehara | Vicente Padilla | George Sherrill | 47 | 49 | -2 |
| 2009-04-14 | vs BAL | 8 | L 5-7 | 4-4 | 3 | 14,041 | Brandon McCarthy | Alfredo Simon | Jim Johnson | Eddie Guardado | | 52 | 56 | -4 |
| 2009-04-15 | vs BAL | 9 | W 19-6 | 4-5 | 4 | 17,539 | Kris Benson | Mark Hendrickson | Kris Benson | Mark Hendrickson | | 71 | 62 | 9 |
| 2009-04-17 | vs KCA | 10 | L 3-12 | 5-5 | 4 | 24,062 | Matt Harrison | Gil Meche | Gil Meche | Matt Harrison | | 74 | 74 | 0 |
| 2009-04-18 | vs KCA | 11 | L 0-2 | 5-6 | 4 | 37,635 | Kevin Millwood | Zack Greinke | Zack Greinke | Kevin Millwood | | 74 | 76 | -2 |
| 2009-04-19 | vs KCA | 12 | W 6-5 | 6-6 | 3 | 27,635 | Vicente Padilla | Kyle Davies | Frank Francisco | Kyle Farnsworth | | 80 | 81 | -1 |
| 2009-04-21 | @ TOR | 13 | W 5-4 | 7-6 | 3 | 20,996 | Brandon McCarthy | Roy Halladay | Brandon McCarthy | Roy Halladay | Frank Francisco | 85 | 85 | 0 |
| 2009-04-22 | @ TOR | 14 | L 7-8 | 7-7 | 3 | 13,090 | Matt Harrison | David Purcey | Jason Frasor | C.J. Wilson | | 92 | 93 | -1 |
| 2009-04-23 | @ TOR | 15 | L 2-5 | 7-8 | 3 | 15,487 | Kevin Millwood | Scott Richmond | Scott Richmond | Kevin Millwood | Scott Downs | 94 | 98 | -4 |
| 2009-04-24 | @ BAL | 16 | W 5-4 | 8-8 | 2 | 24,319 | Vicente Padilla | Koji Uehara | C.J. Wilson | George Sherrill | Frank Francisco | 99 | 102 | -3 |
| 2009-04-25 | @ BAL | 17 | W 6-5 | 9-8 | 2 | 41,160 | Scott Feldman | Mark Hendrickson | Scott Feldman | Mark Hendrickson | Frank Francisco | 105 | 107 | -2 |
| 2009-04-26 | @ BAL | 18 | L 5-8 | 9-9 | 2 | 22,896 | Brandon McCarthy | Brad Bergesen | Danys Baez | Jason Jennings | George Sherrill | 110 | 115 | -5 |
| 2009-04-27 | @ BAL | 19 | W 6-4 | 10-9 | 2 | 10,621 | Matt Harrison | Jeremy Guthrie | Matt Harrison | Matt Albers | Frank Francisco | 116 | 119 | -3 |
| 2009-04-28 | vs OAK | 20 | W 5-4 | 11-9 | 3 | 12,627 | Kevin Millwood | Brett Anderson | Kevin Millwood | Michael Wuertz | Frank Francisco | 121 | 123 | -2 |
| 2009-04-30 | vs OAK | 21 | L 2-4 | 11-10 | 2 | 13,802 | Vicente Padilla | Dallas Braden | Dallas Braden | Vicente Padilla | Michael Wuertz | 123 | 127 | -4 |
| 2009-05-01 | vs CHA | 22 | L 3-4 | 11-11 | 3 | 23,836 | Scott Feldman | Mark Buehrle | Mark Buehrle | Derek Holland | Bobby Jenks | 126 | 131 | -5 |
| 2009-05-02 | vs CHA | 23 | W 9-6 | 12-11 | 3 | 26,673 | Brandon McCarthy | Jose Contreras | Brandon McCarthy | Jose Contreras | Frank Francisco | 135 | 137 | -2 |
| 2009-05-03 | vs CHA | 24 | W 5-1 | 13-11 | 2 | 20,132 | Matt Harrison | John Danks | Matt Harrison | John Danks | | 140 | 138 | 2 |
| 2009-05-04 | @ SEA | 25 | W 6-5 | 14-11 | 1 | 16,421 | Kevin Millwood | Felix Hernandez | Kevin Millwood | Felix Hernandez | Frank Francisco | 146 | 143 | 3 |
| 2009-05-05 | @ SEA | 26 | W 7-2 | 15-11 | 1 | 19,810 | Vicente Padilla | Erik Bedard | Darren O'Day | Denny Stark | | 153 | 145 | 8 |
| 2009-05-06 | @ OAK | 27 | W 3-2 | 16-11 | 1 | 15,342 | Scott Feldman | Dan Giese | Scott Feldman | Dan Giese | Frank Francisco | 156 | 147 | 9 |
| 2009-05-07 | @ OAK | 28 | L 4-9 | 16-12 | 1 | 13,702 | Brandon McCarthy | Trevor Cahill | Trevor Cahill | Brandon McCarthy | | 160 | 156 | 4 |
| 2009-05-08 | @ CHA | 29 | W 6-0 | 17-12 | 1 | 21,326 | Matt Harrison | Jose Contreras | Matt Harrison | Jose Contreras | | 166 | 156 | 10 |
| 2009-05-09 | @ CHA | 30 | L 2-3 | 17-13 | 2 | 28,864 | Kevin Millwood | John Danks | Scott Linebrink | Kevin Millwood | Bobby Jenks | 168 | 159 | 9 |
| 2009-05-10 | @ CHA | 31 | W 7-1 | 18-13 | 2 | 25,844 | Vicente Padilla | Bartolo Colon | Vicente Padilla | Bartolo Colon | | 175 | 160 | 15 |
| 2009-05-12 | vs SEA | 32 | W 7-1 | 19-13 | 1 | 16,564 | Scott Feldman | Jason Vargas | Derek Holland | Mark Lowe | | 182 | 161 | 21 |
| 2009-05-13 | vs SEA | 33 | W 6-5 | 20-13 | 1 | 25,865 | Brandon McCarthy | Jarrod Washburn | C.J. Wilson | Brandon Morrow | | 188 | 166 | 22 |
| 2009-05-14 | vs SEA | 34 | W 3-2 | 21-13 | 1 | 21,002 | Matt Harrison | Felix Hernandez | Matt Harrison | Brandon Morrow | | 191 | 168 | 23 |
| 2009-05-15 | vs ANA | 35 | W 10-8 | 21-14 | 2 | 33,429 | Kevin Millwood | Joe Saunders | Kevin Millwood | Joe Saunders | C.J. Wilson | 201 | 176 | 25 |
| 2009-05-16 | vs ANA | 36 | W 5-3 | 22-14 | 1 | 34,284 | Vicente Padilla | John Lackey | Vicente Padilla | Shane Loux | C.J. Wilson | 206 | 179 | 27 |
| 2009-05-17 | vs ANA | 37 | W 3-0 | 23-14 | 1 | 37,146 | Scott Feldman | Jered Weaver | Jason Jennings | Jered Weaver | Darren O'Day | 209 | 179 | 30 |
| 2009-05-19 | @ DET | 38 | L 0-4 | 23-15 | 1 | 23,756 | Brandon McCarthy | Dontrelle Willis | Dontrelle Willis | Brandon McCarthy | | 209 | 183 | 26 |
| 2009-05-20 | @ DET | 39 | L 3-5 | 23-16 | 1 | 23,417 | Matt Harrison | Justin Verlander | Justin Verlander | Matt Harrison | Fernando Rodney | 212 | 188 | 24 |
| 2009-05-21 | @ DET | 40 | L 3-4 | 23-17 | 2 | 34,356 | Kevin Millwood | Edwin Jackson | Edwin Jackson | Kevin Millwood | Fernando Rodney | 215 | 192 | 23 |
| 2009-05-22 | @ HOU | 41 | W 6-5 | 24-17 | 2 | 36,017 | Derek Holland | Felipe Paulino | Darren O'Day | LaTroy Hawkins | Frank Francisco | 221 | 197 | 24 |
| 2009-05-23 | @ HOU | 42 | W 6-3 | 25-17 | 1 | 36,019 | Scott Feldman | Brian Moehler | Scott Feldman | Brian Moehler | C.J. Wilson | 227 | 200 | 27 |
| 2009-05-24 | @ HOU | 43 | W 5-0 | 26-17 | 1 | 36,749 | Brandon McCarthy | Mike Hampton | Brandon McCarthy | Mike Hampton | | 232 | 200 | 32 |
| 2009-05-25 | vs NYA | 44 | L 1-11 | 26-18 | 1 | 48,914 | Matt Harrison | Phil Hughes | Phil Hughes | Matt Harrison | | 233 | 211 | 22 |
| 2009-05-26 | vs NYA | 45 | W 7-3 | 27-18 | 1 | 33,397 | Kevin Millwood | Joba Chamberlain | Jason Jennings | Alfredo Aceves | | 240 | 214 | 26 |
| 2009-05-27 | vs NYA | 46 | L 2-9 | 27-19 | 1 | 38,409 | Derek Holland | A.J. Burnett | A.J. Burnett | Derek Holland | | 242 | 223 | 19 |
| 2009-05-29 | vs OAK | 47 | W 6-3 | 28-19 | 2 | 0 | Tommy Hunter | Josh Outman | C.J. Wilson | Santiago Casilla | Frank Francisco | 248 | 226 | 22 |
| 2009-05-29 | vs OAK | 48 | W 5-2 | 28-19 | 2 | 30,496 | Scott Feldman | Edgar Gonzalez | Scott Feldman | Edgar Gonzalez | C.J. Wilson | 253 | 228 | 25 |
| 2009-05-30 | vs OAK | 49 | W 14-1 | 30-19 | 1 | 45,325 | Brandon McCarthy | Brett Anderson | Brandon McCarthy | Brett Anderson | | 267 | 229 | 38 |
| 2009-05-31 | vs OAK | 50 | L 4-5 | 30-20 | 1 | 22,952 | Kevin Millwood | Dallas Braden | Andrew Bailey | Frank Francisco | | 271 | 234 | 37 |
| 2009-06-02 | @ NYA | 51 | L 3-12 | 31-20 | 1 | 43,948 | Vicente Padilla | A.J. Burnett | A.J. Burnett | Vicente Padilla | | 274 | 246 | 28 |
| 2009-06-03 | @ NYA | 52 | W 4-2 | 32-20 | 1 | 44,452 | Scott Feldman | Andy Pettitte | Scott Feldman | Andy Pettitte | Frank Francisco | 278 | 248 | 30 |
| 2009-06-04 | @ NYA | 53 | L 6-8 | 32-21 | 1 | 45,713 | Brandon McCarthy | Chien-Ming Wang | David Robertson | C.J. Wilson | Mariano Rivera | 284 | 256 | 28 |
| 2009-06-05 | @ BOS | 54 | W 5-1 | 33-21 | 1 | 37,519 | Kevin Millwood | Brad Penny | Kevin Millwood | Brad Penny | | 289 | 257 | 32 |
| 2009-06-06 | @ BOS | 55 | L 1-8 | 33-22 | 1 | 37,828 | Derek Holland | Jon Lester | Jon Lester | Derek Holland | | 290 | 265 | 25 |
| 2009-06-07 | @ BOS | 56 | W 6-3 | 34-22 | 1 | 37,537 | Vicente Padilla | Daisuke Matsuzaka | Vicente Padilla | Daisuke Matsuzaka | C.J. Wilson | 296 | 268 | 28 |
| 2009-06-08 | vs TOR | 57 | L 3-6 | 34-23 | 1 | 17,856 | Scott Feldman | Casey Janssen | Casey Janssen | Scott Feldman | Scott Downs | 299 | 274 | 25 |
| 2009-06-09 | vs TOR | 58 | L 0-9 | 34-24 | 1 | 17,535 | Doug Mathis | Brian Tallet | Brian Tallet | Doug Mathis | | 299 | 283 | 16 |
| 2009-06-11 | vs TOR | 59 | W 1-0 | 35-24 | 1 | 16,073 | Kevin Millwood | Ricky Romero | Kevin Millwood | Ricky Romero | C.J. Wilson | 300 | 283 | 17 |
| 2009-06-12 | vs LAN | 60 | W 6-0 | 36-24 | 1 | 36,591 | Vicente Padilla | Hiroki Kuroda | Vicente Padilla | Hiroki Kuroda | | 306 | 283 | 23 |
| 2009-06-13 | vs LAN | 61 | L 1-3 | 36-25 | 1 | 37,262 | Scott Feldman | Randy Wolf | Cory Wade | Jason Grilli | Jonathan Broxton | 307 | 286 | 21 |
| 2009-06-14 | vs LAN | 62 | L 3-6 | 36-26 | 1 | 36,343 | Derek Holland | Chad Billingsley | Chad Billingsley | Derek Holland | Jonathan Broxton | 310 | 292 | 18 |
| 2009-06-16 | vs HOU | 63 | W 6-1 | 37-26 | 1 | 21,676 | Kevin Millwood | Wandy Rodriguez | Kevin Millwood | Wandy Rodriguez | | 316 | 293 | 23 |
| 2009-06-17 | vs HOU | 64 | W 5-4 | 38-26 | 1 | 32,425 | Matt Harrison | Russ Ortiz | C.J. Wilson | Jeff Fulchino | | 321 | 297 | 24 |
| 2009-06-18 | vs HOU | 65 | L 3-5 | 38-27 | 1 | 25,445 | Vicente Padilla | Brandon Backe | Alberto Arias | Jason Jennings | Jose Valverde | 324 | 302 | 22 |
| 2009-06-19 | @ SFN | 66 | L 4-6 | 38-28 | 1 | 31,241 | Scott Feldman | Randy Johnson | Sergio Romo | Scott Feldman | Brian Wilson | 328 | 308 | 20 |
| 2009-06-20 | @ SFN | 67 | L 1-2 | 38-29 | 1 | 33,312 | Derek Holland | Matt Cain | Sergio Romo | Jason Jennings | | 329 | 310 | 19 |
| 2009-06-21 | @ SFN | 68 | L 2-3 | 38-30 | 1 | 41,292 | Kevin Millwood | Barry Zito | Barry Zito | Kevin Millwood | Brian Wilson | 331 | 313 | 18 |
| 2009-06-23 | @ ARI | 69 | L 2-8 | 38-31 | 2 | 21,379 | Matt Harrison | Max Scherzer | Max Scherzer | Matt Harrison | | 333 | 321 | 12 |
| 2009-06-24 | @ ARI | 70 | W 2-1 | 39-31 | 1 | 20,031 | Vicente Padilla | Dan Haren | Vicente Padilla | Dan Haren | C.J. Wilson | 335 | 322 | 13 |
| 2009-06-25 | @ ARI | 71 | W 9-8 | 40-31 | 1 | 19,376 | Scott Feldman | Jon Garland | Eddie Guardado | Esmerling Vasquez | Jason Jennings | 344 | 330 | 14 |
| 2009-06-26 | vs SDN | 72 | W 12-2 | 40-32 | 1 | 33,340 | Kevin Millwood | Walter Silva | Kevin Millwood | Walter Silva | | 356 | 332 | 24 |
| 2009-06-27 | vs SDN | 73 | L 3-7 | 40-33 | 1 | 25,410 | Derek Holland | Kevin Correia | Kevin Correia | Derek Holland | | 359 | 339 | 20 |
| 2009-06-28 | vs SDN | 74 | L 0-2 | 40-34 | 1 | 27,000 | Tommy Hunter | Chad Gaudin | Chad Gaudin | Tommy Hunter | Heath Bell | 359 | 341 | 18 |
| 2009-06-29 | vs ANA | 75 | L 2-5 | 40-35 | 2 | 16,985 | Vicente Padilla | Sean O'Sullivan | Sean O'Sullivan | Vicente Padilla | Brian Fuentes | 361 | 346 | 15 |
| 2009-06-30 | vs ANA | 76 | W 9-5 | 41-35 | 1 | 20,042 | Scott Feldman | Joe Saunders | Scott Feldman | Joe Saunders | | 370 | 351 | 19 |
| 2009-07-01 | vs ANA | 77 | W 9-7 | 42-35 | 1 | 27,142 | Kevin Millwood | Jered Weaver | Frank Francisco | Justin Speier | | 379 | 358 | 21 |
| 2009-07-03 | vs TBA | 78 | W 3-1 | 43-35 | 1 | 39,123 | Tommy Hunter | Scott Kazmir | Tommy Hunter | Scott Kazmir | Frank Francisco | 382 | 359 | 23 |
| 2009-07-04 | vs TBA | 79 | W 12-4 | 43-36 | 1 | 43,809 | Derek Holland | David Price | Derek Holland | David Price | | 394 | 363 | 31 |
| 2009-07-05 | vs TBA | 80 | W 5-2 | 44-36 | 1 | 22,324 | Scott Feldman | Matt Garza | Scott Feldman | Matt Garza | Frank Francisco | 399 | 365 | 34 |
| 2009-07-06 | @ ANA | 81 | L 4-9 | 44-37 | 1 | 35,691 | Kevin Millwood | Jered Weaver | Jered Weaver | Kevin Millwood | | 403 | 374 | 29 |
| 2009-07-07 | @ ANA | 82 | W 8-5 | 45-37 | 1 | 42,088 | Dustin Nippert | John Lackey | Derek Holland | John Lackey | | 411 | 379 | 32 |
| 2009-07-08 | @ ANA | 83 | W 8-1 | 46-37 | 1 | 37,364 | Vicente Padilla | Ervin Santana | Vicente Padilla | Ervin Santana | | 419 | 380 | 39 |
| 2009-07-09 | @ SEA | 84 | L 1-3 | 46-38 | 1 | 24,823 | Tommy Hunter | Felix Hernandez | Felix Hernandez | C.J. Wilson | David Aardsma | 420 | 383 | 37 |
| 2009-07-10 | @ SEA | 85 | W 6-4 | 47-38 | 1 | 34,874 | Scott Feldman | Brandon Morrow | Scott Feldman | Brandon Morrow | Frank Francisco | 426 | 387 | 39 |
| 2009-07-11 | @ SEA | 86 | L 1-4 | 47-39 | 1 | 30,698 | Kevin Millwood | Jarrod Washburn | Jarrod Washburn | Kevin Millwood | David Aardsma | 427 | 391 | 36 |
| 2009-07-12 | @ SEA | 87 | L 3-5 | 47-40 | 1 | 33,220 | Dustin Nippert | Erik Bedard | Miguel Batista | Darren O'Day | David Aardsma | 430 | 396 | 34 |
| 2009-07-17 | vs MIN | 88 | L 3-5 | 47-41 | 1 | 34,662 | Vicente Padilla | Glen Perkins | Glen Perkins | Vicente Padilla | Joe Nathan | 433 | 401 | 32 |
| 2009-07-18 | vs MIN | 89 | L 1-4 | 47-42 | 2 | 31,041 | Scott Feldman | Scott Baker | Scott Baker | Scott Feldman | Joe Nathan | 434 | 405 | 29 |
| 2009-07-19 | vs MIN | 90 | W 5-3 | 48-42 | 2 | 27,204 | Derek Holland | Francisco Liriano | Dustin Nippert | Brian Duensing | | 439 | 408 | 31 |
| 2009-07-20 | vs BOS | 91 | W 6-3 | 49-42 | 2 | 28,916 | Kevin Millwood | John Smoltz | Kevin Millwood | John Smoltz | C.J. Wilson | 445 | 411 | 34 |
| 2009-07-21 | vs BOS | 92 | W 4-2 | 50-42 | 1 | 28,555 | Tommy Hunter | Josh Beckett | Tommy Hunter | Josh Beckett | C.J. Wilson | 449 | 413 | 36 |
| 2009-07-22 | vs BOS | 93 | W 3-1 | 51-42 | 1 | 39,778 | Dustin Nippert | Clay Buchholz | Dustin Nippert | Clay Buchholz | Doug Mathis | 452 | 414 | 38 |
| 2009-07-24 | @ KCA | 94 | W 2-0 | 52-42 | 1 | 25,012 | Scott Feldman | Zack Greinke | Scott Feldman | Zack Greinke | C.J. Wilson | 454 | 414 | 40 |
| 2009-07-25 | @ KCA | 95 | L 3-6 | 52-43 | 1 | 27,602 | Derek Holland | Luke Hochevar | Luke Hochevar | Derek Holland | Joakim Soria | 457 | 420 | 37 |
| 2009-07-26 | @ KCA | 96 | W 7-2 | 53-43 | 1 | 16,847 | Kevin Millwood | Sidney Ponson | Dustin Nippert | Ron Mahay | | 464 | 422 | 42 |
| 2009-07-27 | vs DET | 97 | W 5-2 | 54-43 | 1 | 17,173 | Tommy Hunter | Armando Galarraga | Tommy Hunter | Armando Galarraga | C.J. Wilson | 469 | 424 | 45 |
| 2009-07-28 | vs DET | 98 | W 7-3 | 55-43 | 1 | 21,615 | Doug Mathis | Lucas French | Jason Grilli | Lucas French | | 476 | 427 | 49 |
| 2009-07-29 | vs DET | 99 | L 5-13 | 56-43 | 1 | 33,235 | Scott Feldman | Justin Verlander | Justin Verlander | Scott Feldman | | 481 | 440 | 41 |
| 2009-07-30 | vs SEA | 100 | W 7-1 | 57-43 | 1 | 23,949 | Derek Holland | Garrett Olson | Derek Holland | Garrett Olson | | 488 | 441 | 47 |
| 2009-07-31 | vs SEA | 101 | W 5-4 | 58-43 | 1 | 36,901 | Vicente Padilla | Jason Vargas | Vicente Padilla | Jason Vargas | C.J. Wilson | 493 | 445 | 48 |
| 2009-08-01 | vs SEA | 102 | L 2-7 | 58-44 | 1 | 29,458 | Tommy Hunter | Felix Hernandez | Felix Hernandez | Tommy Hunter | | 495 | 452 | 43 |
| 2009-08-02 | vs SEA | 103 | W 4-2 | 59-44 | 1 | 28,670 | Scott Feldman | Ian Snell | Scott Feldman | Sean White | C.J. Wilson | 499 | 454 | 45 |
| 2009-08-03 | @ OAK | 104 | L 2-3 | 59-45 | 1 | 10,523 | Dustin Nippert | Brett Anderson | Michael Wuertz | C.J. Wilson | | 501 | 457 | 44 |
| 2009-08-04 | @ OAK | 105 | L 0-6 | 59-46 | 1 | 10,781 | Derek Holland | Gio Gonzalez | Gio Gonzalez | Derek Holland | | 501 | 463 | 38 |
| 2009-08-05 | @ OAK | 106 | L 5-7 | 59-47 | 1 | 20,560 | Vicente Padilla | Chad Reineke | Craig Breslow | Vicente Padilla | Andrew Bailey | 506 | 470 | 36 |
| 2009-08-06 | @ OAK | 107 | W 6-4 | 60-47 | 1 | 17,214 | Tommy Hunter | Trevor Cahill | Tommy Hunter | Trevor Cahill | C.J. Wilson | 512 | 474 | 38 |
| 2009-08-07 | @ ANA | 108 | W 11-6 | 60-48 | 1 | 43,624 | Scott Feldman | Joe Saunders | Scott Feldman | Joe Saunders | | 523 | 480 | 43 |
| 2009-08-08 | @ ANA | 109 | L 2-3 | 60-49 | 2 | 37,166 | Kevin Millwood | Jered Weaver | Jered Weaver | Eddie Guardado | Brian Fuentes | 525 | 483 | 42 |
| 2009-08-09 | @ ANA | 110 | W 7-0 | 61-49 | 1 | 35,706 | Derek Holland | John Lackey | Derek Holland | John Lackey | | 532 | 483 | 49 |
| 2009-08-11 | @ CLE | 111 | L 0-5 | 61-50 | 1 | 21,870 | Dustin Nippert | Aaron Laffey | Aaron Laffey | Dustin Nippert | | 532 | 488 | 44 |
| 2009-08-12 | @ CLE | 112 | W 5-0 | 62-50 | 1 | 18,794 | Tommy Hunter | Fausto Carmona | Tommy Hunter | Fausto Carmona | | 537 | 488 | 49 |
| 2009-08-13 | @ CLE | 113 | W 4-1 | 63-50 | 1 | 20,090 | Scott Feldman | Jeremy Sowers | Scott Feldman | Jeremy Sowers | Frank Francisco | 541 | 489 | 52 |
| 2009-08-14 | vs BOS | 114 | L 4-8 | 63-51 | 1 | 40,311 | Kevin Millwood | Jon Lester | Takashi Saito | Frank Francisco | | 545 | 497 | 48 |
| 2009-08-15 | vs BOS | 115 | W 7-2 | 64-51 | 1 | 48,201 | Derek Holland | Brad Penny | Derek Holland | Brad Penny | Neftali Feliz | 552 | 499 | 53 |
| 2009-08-16 | vs BOS | 116 | W 4-3 | 65-51 | 1 | 27,155 | Dustin Nippert | Junichi Tazawa | Dustin Nippert | Junichi Tazawa | Frank Francisco | 556 | 502 | 54 |
| 2009-08-17 | vs MIN | 117 | W 8-5 | 66-51 | 1 | 17,940 | Tommy Hunter | Francisco Liriano | Tommy Hunter | Francisco Liriano | Frank Francisco | 564 | 507 | 57 |
| 2009-08-18 | vs MIN | 118 | L 6-9 | 66-52 | 1 | 20,931 | Scott Feldman | Carl Pavano | Jesse Crain | Jason Jennings | Joe Nathan | 570 | 516 | 54 |
| 2009-08-19 | vs MIN | 119 | L 4-5 | 66-53 | 1 | 33,479 | Kevin Millwood | Scott Baker | Scott Baker | Kevin Millwood | Joe Nathan | 574 | 521 | 53 |
| 2009-08-20 | vs MIN | 120 | W 11-1 | 67-53 | 1 | 21,870 | Derek Holland | Anthony Swarzak | Derek Holland | Anthony Swarzak | | 585 | 522 | 63 |
| 2009-08-21 | @ TBA | 121 | L 3-5 | 67-54 | 1 | 20,639 | Dustin Nippert | Scott Kazmir | Scott Kazmir | Dustin Nippert | J.P. Howell | 588 | 527 | 61 |
| 2009-08-22 | @ TBA | 122 | L 4-5 | 67-55 | 1 | 34,281 | Tommy Hunter | Matt Garza | Grant Balfour | Jason Grilli | | 592 | 532 | 60 |
| 2009-08-23 | @ TBA | 123 | W 4-0 | 68-55 | 1 | 29,101 | Scott Feldman | David Price | Scott Feldman | David Price | | 596 | 532 | 64 |
| 2009-08-25 | @ NYA | 124 | W 10-9 | 68-56 | 1 | 46,511 | Kevin Millwood | Joba Chamberlain | Kevin Millwood | Joba Chamberlain | | 606 | 541 | 65 |
| 2009-08-26 | @ NYA | 125 | L 2-9 | 68-57 | 1 | 46,461 | Derek Holland | Andy Pettitte | Andy Pettitte | Derek Holland | | 608 | 550 | 58 |
| 2009-08-27 | @ NYA | 126 | W 7-2 | 69-57 | 1 | 47,209 | Dustin Nippert | A.J. Burnett | Jason Grilli | A.J. Burnett | | 615 | 552 | 63 |
| 2009-08-28 | @ MIN | 127 | L 2-3 | 69-58 | 1 | 21,641 | Tommy Hunter | Brian Duensing | Brian Duensing | Tommy Hunter | Joe Nathan | 617 | 555 | 62 |
| 2009-08-29 | @ MIN | 128 | W 3-0 | 70-58 | 1 | 28,516 | Scott Feldman | Carl Pavano | Scott Feldman | Carl Pavano | Frank Francisco | 620 | 555 | 65 |
| 2009-08-30 | @ MIN | 129 | L 3-5 | 70-59 | 1 | 29,282 | Kevin Millwood | Scott Baker | Jon Rauch | C.J. Wilson | Joe Nathan | 623 | 560 | 63 |
| 2009-08-31 | vs TOR | 130 | L 10-18 | 70-60 | 1 | 16,675 | Derek Holland | Brett Cecil | Brett Cecil | Derek Holland | | 633 | 578 | 55 |
| 2009-09-01 | vs TOR | 131 | W 5-2 | 71-60 | 2 | 0 | Dustin Nippert | Marc Rzepczynski | Dustin Nippert | Marc Rzepczynski | Frank Francisco | 638 | 580 | 58 |
| 2009-09-01 | vs TOR | 132 | W 5-2 | 71-60 | 2 | 17,203 | Brandon McCarthy | Brian Tallet | Brandon McCarthy | Brian Tallet | Frank Francisco | 643 | 582 | 61 |
| 2009-09-02 | vs TOR | 133 | W 6-4 | 73-60 | 1 | 21,836 | Tommy Hunter | Scott Richmond | Tommy Hunter | Scott Richmond | Frank Francisco | 649 | 586 | 63 |
| 2009-09-04 | @ BAL | 134 | W 5-1 | 74-60 | 1 | 15,557 | Scott Feldman | Chris Tillman | Scott Feldman | Chris Tillman | Neftali Feliz | 654 | 587 | 67 |
| 2009-09-05 | @ BAL | 135 | L 4-5 | 74-61 | 1 | 18,028 | Kevin Millwood | Brian Matusz | Brian Matusz | Kevin Millwood | Jim Johnson | 658 | 592 | 66 |
| 2009-09-06 | @ BAL | 136 | L 0-7 | 74-62 | 1 | 21,599 | Derek Holland | Jeremy Guthrie | Jeremy Guthrie | Derek Holland | | 658 | 599 | 59 |
| 2009-09-08 | @ CLE | 137 | W 11-9 | 74-64 | 2 | 0 | Tommy Hunter | Carlos Carrasco | Neftali Feliz | Jensen Lewis | | 669 | 608 | 61 |
| 2009-09-08 | @ CLE | 138 | W 10-5 | 74-64 | 2 | 12,976 | Brandon McCarthy | Aaron Laffey | Brandon McCarthy | Aaron Laffey | Darren O'Day | 679 | 613 | 66 |
| 2009-09-09 | @ CLE | 139 | W 10-0 | 75-64 | 1 | 14,637 | Scott Feldman | Fausto Carmona | Scott Feldman | Fausto Carmona | | 689 | 613 | 76 |
| 2009-09-12 | vs SEA | 140 | L 3-8 | 75-65 | 1 | 22,468 | Kevin Millwood | Brandon Morrow | Brandon Morrow | Kevin Millwood | | 692 | 621 | 71 |
| 2009-09-13 | vs SEA | 141 | W 7-2 | 76-66 | 3 | 0 | Tommy Hunter | Doug Fister | Tommy Hunter | Doug Fister | | 699 | 623 | 76 |
| 2009-09-13 | vs SEA | 142 | L 0-5 | 76-66 | 3 | 18,522 | Derek Holland | Felix Hernandez | Felix Hernandez | Derek Holland | | 699 | 628 | 71 |
| 2009-09-14 | vs OAK | 143 | L 0-9 | 76-67 | 2 | 13,669 | Scott Feldman | Brett Tomko | Brett Tomko | Scott Feldman | | 699 | 637 | 62 |
| 2009-09-15 | vs OAK | 144 | L 1-6 | 76-68 | 2 | 15,964 | Brandon McCarthy | Edgar Gonzalez | Craig Breslow | Brandon McCarthy | | 700 | 643 | 57 |
| 2009-09-16 | vs OAK | 145 | L 0-4 | 76-69 | 3 | 23,372 | Dustin Nippert | Trevor Cahill | Trevor Cahill | Dustin Nippert | | 700 | 647 | 53 |
| 2009-09-18 | vs ANA | 146 | L 0-2 | 76-70 | 3 | 34,240 | Tommy Hunter | Scott Kazmir | Scott Kazmir | Tommy Hunter | Brian Fuentes | 700 | 649 | 51 |
| 2009-09-19 | vs ANA | 147 | W 3-2 | 77-70 | 3 | 46,596 | Scott Feldman | Jered Weaver | Scott Feldman | Jered Weaver | Frank Francisco | 703 | 651 | 52 |
| 2009-09-20 | vs ANA | 148 | L 5-10 | 78-70 | 2 | 33,688 | Derek Holland | John Lackey | John Lackey | Derek Holland | | 708 | 661 | 47 |
| 2009-09-21 | @ OAK | 149 | W 10-3 | 78-71 | 3 | 10,581 | Kevin Millwood | Edgar Gonzalez | Kevin Millwood | Edgar Gonzalez | | 718 | 664 | 54 |
| 2009-09-22 | @ OAK | 150 | L 1-9 | 78-72 | 3 | 10,475 | Brandon McCarthy | Trevor Cahill | Trevor Cahill | Brandon McCarthy | | 719 | 673 | 46 |
| 2009-09-23 | @ OAK | 151 | W 9-8 | 79-72 | 2 | 18,311 | Tommy Hunter | Clayton Mortenson | Tommy Hunter | Clayton Mortenson | Frank Francisco | 728 | 681 | 47 |
| 2009-09-24 | @ OAK | 152 | L 3-12 | 80-72 | 2 | 11,124 | Scott Feldman | Brett Anderson | Brett Anderson | Scott Feldman | | 731 | 693 | 38 |
| 2009-09-25 | vs TBA | 153 | W 8-3 | 81-72 | 2 | 29,232 | Derek Holland | James Shields | Derek Holland | James Shields | | 739 | 696 | 43 |
| 2009-09-26 | vs TBA | 154 | W 15-3 | 81-73 | 2 | 31,855 | Kevin Millwood | Matt Garza | Kevin Millwood | Matt Garza | | 754 | 699 | 55 |
| 2009-09-27 | vs TBA | 155 | L 6-7 | 81-74 | 2 | 37,905 | Brandon McCarthy | David Price | Randy Choate | Frank Francisco | Lance Cormier | 760 | 706 | 54 |
| 2009-09-28 | @ ANA | 156 | L 0-11 | 81-75 | 3 | 40,484 | Tommy Hunter | Ervin Santana | Ervin Santana | Tommy Hunter | | 760 | 717 | 43 |
| 2009-09-29 | @ ANA | 157 | L 2-5 | 81-76 | 3 | 38,600 | Scott Feldman | Sean O'Sullivan | Sean O'Sullivan | Scott Feldman | Brian Fuentes | 762 | 722 | 40 |
| 2009-09-30 | @ ANA | 158 | L 0-5 | 81-77 | 3 | 40,616 | Derek Holland | Matt Palmer | Matt Palmer | Derek Holland | | 762 | 727 | 35 |
| 2009-10-01 | @ ANA | 159 | W 11-3 | 81-78 | 3 | 38,552 | Kevin Millwood | John Lackey | Kevin Millwood | Trevor Bell | | 773 | 730 | 43 |
| 2009-10-02 | @ SEA | 160 | W 7-4 | 82-78 | 3 | 27,899 | Brandon McCarthy | Ian Snell | C.J. Wilson | David Aardsma | Frank Francisco | 780 | 734 | 46 |
| 2009-10-03 | @ SEA | 161 | L 1-2 | 82-79 | 3 | 24,391 | Tommy Hunter | Ryan Rowland-Smith | Ryan Rowland-Smith | Tommy Hunter | Miguel Batista | 781 | 736 | 45 |
| 2009-10-04 | @ SEA | 162 | L 3-4 | 82-80 | 3 | 32,260 | Scott Feldman | Felix Hernandez | Felix Hernandez | Scott Feldman | David Aardsma | 784 | 740 | 44 |