| 2009-04-06 | vs COL | 1 | W 9-8 | 1-0 | 1 | 48,799 | Brandon Webb | Aaron Cook | Tony Pena | Jason Grilli | Chad Qualls | 9 | 8 | 1 |
| 2009-04-07 | vs COL | 2 | L 0-3 | 1-1 | 1 | 26,637 | Dan Haren | Ubaldo Jimenez | Ubaldo Jimenez | Dan Haren | Huston Street | 9 | 11 | -2 |
| 2009-04-08 | vs COL | 3 | L 2-9 | 1-2 | 3 | 18,227 | Doug Davis | Franklin Morales | Franklin Morales | Doug Davis | | 11 | 20 | -9 |
| 2009-04-10 | vs LAN | 4 | W 9-4 | 2-2 | 2 | 31,036 | Jon Garland | James McDonald | Jon Garland | James McDonald | | 20 | 24 | -4 |
| 2009-04-11 | vs LAN | 5 | L 2-11 | 3-2 | 2 | 35,024 | Yusmeiro Petit | Eric Stults | Eric Stults | Yusmeiro Petit | | 22 | 35 | -13 |
| 2009-04-12 | vs LAN | 6 | L 1-3 | 3-3 | 2 | 25,485 | Dan Haren | Randy Wolf | Randy Wolf | Dan Haren | Jonathan Broxton | 23 | 38 | -15 |
| 2009-04-13 | vs SLN | 7 | L 1-2 | 3-4 | 3 | 25,014 | Doug Davis | Todd Wellemeyer | Todd Wellemeyer | Doug Davis | Ryan Franklin | 24 | 40 | -16 |
| 2009-04-14 | vs SLN | 8 | W 7-6 | 4-4 | 2 | 25,678 | Max Scherzer | Chris Carpenter | Tony Pena | Brad Thompson | | 31 | 46 | -15 |
| 2009-04-15 | vs SLN | 9 | L 7-12 | 5-4 | 2 | 21,298 | Jon Garland | Joel Pineiro | Joel Pineiro | Jon Garland | | 38 | 58 | -20 |
| 2009-04-17 | @ SFN | 10 | L 0-2 | 5-5 | 3 | 34,898 | Dan Haren | Jonathan Sanchez | Jonathan Sanchez | Dan Haren | Brian Wilson | 38 | 60 | -22 |
| 2009-04-18 | @ SFN | 11 | W 2-0 | 6-5 | 3 | 37,409 | Doug Davis | Tim Lincecum | Doug Davis | Jeremy Affeldt | Chad Qualls | 40 | 60 | -20 |
| 2009-04-19 | @ SFN | 12 | L 0-2 | 6-6 | 3 | 35,350 | Max Scherzer | Randy Johnson | Randy Johnson | Max Scherzer | Brian Wilson | 40 | 62 | -22 |
| 2009-04-20 | vs COL | 13 | W 6-3 | 7-6 | 3 | 25,788 | Jon Garland | Jason Marquis | Jon Garland | Jason Marquis | Chad Qualls | 46 | 65 | -19 |
| 2009-04-21 | vs COL | 14 | L 6-9 | 7-7 | 3 | 25,411 | Yusmeiro Petit | Franklin Morales | Matt Belisle | Juan Gutierrez | Manuel Corpas | 52 | 74 | -22 |
| 2009-04-22 | vs COL | 15 | W 2-0 | 8-7 | 2 | 19,147 | Dan Haren | Jorge de la Rosa | Dan Haren | Jorge de la Rosa | Chad Qualls | 54 | 74 | -20 |
| 2009-04-24 | vs SFN | 16 | L 1-5 | 8-8 | 3 | 27,865 | Doug Davis | Tim Lincecum | Tim Lincecum | Doug Davis | | 55 | 79 | -24 |
| 2009-04-25 | vs SFN | 17 | L 3-5 | 8-9 | 3 | 37,253 | Max Scherzer | Randy Johnson | Justin Miller | Max Scherzer | Brian Wilson | 58 | 84 | -26 |
| 2009-04-26 | vs SFN | 18 | W 5-4 | 9-9 | 3 | 31,862 | Jon Garland | Matt Cain | Juan Gutierrez | Brandon Medders | | 63 | 88 | -25 |
| 2009-04-27 | vs CHN | 19 | W 7-2 | 10-9 | 3 | 29,471 | Dan Haren | Ted Lilly | Dan Haren | Ted Lilly | | 70 | 90 | -20 |
| 2009-04-28 | vs CHN | 20 | L 3-11 | 11-9 | 3 | 30,351 | Yusmeiro Petit | Carlos Zambrano | Carlos Zambrano | Yusmeiro Petit | | 73 | 101 | -28 |
| 2009-04-29 | vs CHN | 21 | W 10-0 | 12-9 | 2 | 26,999 | Doug Davis | Ryan Dempster | Doug Davis | Ryan Dempster | | 83 | 101 | -18 |
| 2009-04-30 | @ MIL | 22 | L 1-4 | 12-10 | 2 | 26,464 | Max Scherzer | Jeff Suppan | Mark DiFelice | Tom Gordon | Trevor Hoffman | 84 | 105 | -21 |
| 2009-05-01 | @ MIL | 23 | W 5-2 | 13-10 | 2 | 42,810 | Jon Garland | Manny Parra | Tony Pena | Carlos Villanueva | Chad Qualls | 89 | 107 | -18 |
| 2009-05-02 | @ MIL | 24 | W 4-1 | 14-10 | 2 | 42,422 | Dan Haren | Braden Looper | Dan Haren | Braden Looper | Chad Qualls | 93 | 108 | -15 |
| 2009-05-03 | @ MIL | 25 | L 3-4 | 14-11 | 2 | 44,727 | Yusmeiro Petit | David Bush | Mitch Stetter | Juan Gutierrez | Trevor Hoffman | 96 | 112 | -16 |
| 2009-05-04 | @ LAN | 26 | L 2-7 | 14-12 | 2 | 30,530 | Doug Davis | Eric Stults | Eric Stults | Doug Davis | | 98 | 119 | -21 |
| 2009-05-05 | @ LAN | 27 | L 1-3 | 14-13 | 2 | 33,557 | Max Scherzer | Jeff Weaver | Jeff Weaver | Max Scherzer | Jonathan Broxton | 99 | 122 | -23 |
| 2009-05-06 | @ SDN | 28 | W 3-1 | 15-13 | 2 | 15,092 | Jon Garland | Jake Peavy | Jon Garland | Jake Peavy | Chad Qualls | 102 | 123 | -21 |
| 2009-05-07 | @ SDN | 29 | L 3-4 | 15-14 | 2 | 18,921 | Dan Haren | Chris Young | Cla Meredith | Esmerling Vasquez | | 105 | 127 | -22 |
| 2009-05-08 | vs WAS | 30 | L 4-5 | 15-15 | 2 | 28,640 | Yusmeiro Petit | Shairon Martis | Shairon Martis | Yusmeiro Petit | Kip Wells | 109 | 132 | -23 |
| 2009-05-09 | vs WAS | 31 | L 1-2 | 15-16 | 2 | 27,233 | Doug Davis | John Lannan | John Lannan | Doug Davis | Joel Hanrahan | 110 | 134 | -24 |
| 2009-05-10 | vs WAS | 32 | W 10-8 | 15-17 | 3 | 25,086 | Max Scherzer | Scott Olsen | Esmerling Vasquez | Logan Kensing | Chad Qualls | 120 | 142 | -22 |
| 2009-05-11 | vs CIN | 33 | L 5-13 | 16-17 | 2 | 17,640 | Jon Garland | Bronson Arroyo | Bronson Arroyo | Jon Garland | | 125 | 155 | -30 |
| 2009-05-12 | vs CIN | 34 | L 1-3 | 16-18 | 3 | 24,835 | Dan Haren | Micah Owings | Micah Owings | Dan Haren | Francisco Cordero | 126 | 158 | -32 |
| 2009-05-13 | vs CIN | 35 | L 3-10 | 17-18 | 2 | 20,443 | Bryan Augenstein | Johnny Cueto | Johnny Cueto | Bryan Augenstein | | 129 | 168 | -39 |
| 2009-05-15 | @ ATL | 36 | L 3-4 | 17-19 | 2 | 32,593 | Doug Davis | Javier Vazquez | Mike Gonzalez | Tony Pena | | 132 | 172 | -40 |
| 2009-05-16 | @ ATL | 37 | W 12-0 | 18-19 | 2 | 30,162 | Max Scherzer | Kenshin Kawakami | Max Scherzer | Kenshin Kawakami | | 144 | 172 | -28 |
| 2009-05-19 | @ FLO | 38 | W 5-3 | 19-19 | 3 | 10,131 | Jon Garland | Josh Johnson | Jon Garland | Josh Johnson | Chad Qualls | 149 | 175 | -26 |
| 2009-05-20 | @ FLO | 39 | L 6-8 | 19-21 | 4 | 0 | Doug Davis | Chris Volstad | Chris Volstad | Doug Davis | Matt Lindstrom | 155 | 183 | -28 |
| 2009-05-20 | @ FLO | 40 | W 11-9 | 19-21 | 4 | 14,426 | Bryan Augenstein | Hayden Penn | Chad Qualls | Leo Nunez | Jon Rauch | 166 | 192 | -26 |
| 2009-05-21 | @ FLO | 41 | W 4-3 | 20-21 | 3 | 12,045 | Max Scherzer | Andrew Miller | Clay Zavada | Cristhian Martinez | Chad Qualls | 170 | 195 | -25 |
| 2009-05-22 | @ OAK | 42 | W 2-1 | 21-21 | 3 | 13,586 | Billy Buckner | Trevor Cahill | Billy Buckner | Trevor Cahill | Jon Rauch | 172 | 196 | -24 |
| 2009-05-23 | @ OAK | 43 | W 8-7 | 22-21 | 3 | 21,295 | Dan Haren | Edgar Gonzalez | Tony Pena | Craig Breslow | Chad Qualls | 180 | 203 | -23 |
| 2009-05-24 | @ OAK | 44 | L 2-6 | 22-22 | 3 | 13,792 | Jon Garland | Josh Outman | Josh Outman | Jon Garland | | 182 | 209 | -27 |
| 2009-05-25 | vs SDN | 45 | L 7-9 | 22-23 | 3 | 30,546 | Doug Davis | Chad Gaudin | Edward Mujica | Tony Pena | Heath Bell | 189 | 218 | -29 |
| 2009-05-26 | vs SDN | 46 | W 6-5 | 23-23 | 3 | 18,631 | Max Scherzer | Kevin Correia | Max Scherzer | Kevin Correia | Juan Gutierrez | 195 | 223 | -28 |
| 2009-05-27 | vs SDN | 47 | L 5-8 | 23-24 | 3 | 18,264 | Billy Buckner | Jake Peavy | Jake Peavy | Billy Buckner | Heath Bell | 200 | 231 | -31 |
| 2009-05-28 | vs ATL | 48 | W 5-2 | 24-24 | 3 | 19,452 | Dan Haren | Derek Lowe | Dan Haren | Derek Lowe | Chad Qualls | 205 | 233 | -28 |
| 2009-05-29 | vs ATL | 49 | L 6-10 | 25-24 | 3 | 26,146 | Jon Garland | Jair Jurrjens | Jair Jurrjens | Jon Garland | | 211 | 243 | -32 |
| 2009-05-30 | vs ATL | 50 | W 3-2 | 26-24 | 3 | 35,039 | Doug Davis | Javier Vazquez | Tony Pena | Jeff Bennett | | 214 | 245 | -31 |
| 2009-05-31 | vs ATL | 51 | L 3-9 | 26-25 | 3 | 30,020 | Max Scherzer | Kris Medlen | Kris Medlen | Max Scherzer | | 217 | 254 | -37 |
| 2009-06-01 | @ LAN | 52 | W 3-2 | 27-25 | 3 | 32,304 | Billy Buckner | Hiroki Kuroda | Billy Buckner | Hiroki Kuroda | Tony Pena | 220 | 256 | -36 |
| 2009-06-02 | @ LAN | 53 | L 5-6 | 27-26 | 3 | 32,853 | Dan Haren | Randy Wolf | Jeff Weaver | Daniel Schlereth | Jonathan Broxton | 225 | 262 | -37 |
| 2009-06-03 | @ LAN | 54 | L 0-1 | 27-27 | 3 | 33,804 | Jon Garland | Chad Billingsley | Chad Billingsley | Jon Garland | Jonathan Broxton | 225 | 263 | -38 |
| 2009-06-05 | @ SDN | 55 | W 8-0 | 28-27 | 4 | 22,426 | Doug Davis | Chad Gaudin | Doug Davis | Chad Gaudin | | 233 | 263 | -30 |
| 2009-06-06 | @ SDN | 56 | L 4-6 | 28-28 | 3 | 23,592 | Max Scherzer | Kevin Correia | Kevin Correia | Daniel Schlereth | Heath Bell | 237 | 269 | -32 |
| 2009-06-07 | @ SDN | 57 | W 9-6 | 29-28 | 4 | 27,804 | Dan Haren | Josh Geer | Leo Rosales | Josh Wilson | | 246 | 275 | -29 |
| 2009-06-08 | @ SDN | 58 | L 3-6 | 29-29 | 3 | 17,501 | Jon Garland | Jake Peavy | Jake Peavy | Jon Garland | Heath Bell | 249 | 281 | -32 |
| 2009-06-09 | vs SFN | 59 | L 4-9 | 29-30 | 4 | 22,428 | Billy Buckner | Matt Cain | Matt Cain | Billy Buckner | | 253 | 290 | -37 |
| 2009-06-10 | vs SFN | 60 | L 4-6 | 29-31 | 4 | 19,837 | Doug Davis | Barry Zito | Barry Zito | Doug Davis | Brian Wilson | 257 | 296 | -39 |
| 2009-06-11 | vs SFN | 61 | W 2-1 | 30-31 | 4 | 24,389 | Max Scherzer | Jonathan Sanchez | Max Scherzer | Jonathan Sanchez | Chad Qualls | 259 | 297 | -38 |
| 2009-06-12 | vs HOU | 62 | W 8-1 | 31-31 | 4 | 22,225 | Dan Haren | Mike Hampton | Dan Haren | Mike Hampton | | 267 | 298 | -31 |
| 2009-06-13 | vs HOU | 63 | L 4-6 | 31-32 | 4 | 29,206 | Jon Garland | Roy Oswalt | Roy Oswalt | Jon Garland | LaTroy Hawkins | 271 | 304 | -33 |
| 2009-06-14 | vs HOU | 64 | L 3-8 | 31-33 | 4 | 26,937 | Billy Buckner | Brian Moehler | Brian Moehler | Billy Buckner | | 274 | 312 | -38 |
| 2009-06-16 | @ KCA | 65 | L 0-5 | 31-34 | 5 | 26,974 | Doug Davis | Gil Meche | Gil Meche | Doug Davis | | 274 | 317 | -43 |
| 2009-06-17 | @ KCA | 66 | W 12-5 | 31-35 | 5 | 29,777 | Max Scherzer | Zack Greinke | Max Scherzer | Zack Greinke | | 286 | 322 | -36 |
| 2009-06-18 | @ KCA | 67 | W 12-5 | 31-36 | 5 | 14,129 | Dan Haren | Luke Hochevar | Dan Haren | Luke Hochevar | | 298 | 327 | -29 |
| 2009-06-19 | @ SEA | 68 | L 3-4 | 31-37 | 5 | 27,319 | Jon Garland | Jarrod Washburn | Miguel Batista | Tony Pena | David Aardsma | 301 | 331 | -30 |
| 2009-06-20 | @ SEA | 69 | L 3-7 | 31-38 | 5 | 29,525 | Billy Buckner | Jason Vargas | Jason Vargas | Billy Buckner | David Aardsma | 304 | 338 | -34 |
| 2009-06-21 | @ SEA | 70 | L 2-3 | 31-39 | 5 | 37,251 | Doug Davis | Felix Hernandez | Mark Lowe | Clay Zavada | | 306 | 341 | -35 |
| 2009-06-23 | vs TEX | 71 | W 8-2 | 32-39 | 5 | 21,379 | Max Scherzer | Matt Harrison | Max Scherzer | Matt Harrison | | 314 | 343 | -29 |
| 2009-06-24 | vs TEX | 72 | L 1-2 | 32-40 | 5 | 20,031 | Dan Haren | Vicente Padilla | Vicente Padilla | Dan Haren | C.J. Wilson | 315 | 345 | -30 |
| 2009-06-25 | vs TEX | 73 | L 8-9 | 32-41 | 5 | 19,376 | Jon Garland | Scott Feldman | Eddie Guardado | Esmerling Vasquez | Jason Jennings | 323 | 354 | -31 |
| 2009-06-26 | vs ANA | 74 | L 3-12 | 33-41 | 5 | 24,870 | Billy Buckner | Jered Weaver | Jered Weaver | Billy Buckner | | 326 | 366 | -40 |
| 2009-06-27 | vs ANA | 75 | L 1-2 | 33-42 | 5 | 27,742 | Doug Davis | John Lackey | Darren Oliver | Chad Qualls | Brian Fuentes | 327 | 368 | -41 |
| 2009-06-28 | vs ANA | 76 | L 8-12 | 34-42 | 5 | 25,684 | Max Scherzer | Matt Palmer | Matt Palmer | Max Scherzer | | 335 | 380 | -45 |
| 2009-06-30 | @ CIN | 77 | W 6-2 | 35-42 | 5 | 22,725 | Dan Haren | Bronson Arroyo | Dan Haren | Bronson Arroyo | | 341 | 382 | -41 |
| 2009-07-01 | @ CIN | 78 | L 0-1 | 35-43 | 5 | 20,374 | Jon Garland | Johnny Cueto | Johnny Cueto | Jon Garland | Francisco Cordero | 341 | 383 | -42 |
| 2009-07-02 | @ CIN | 79 | L 2-3 | 35-44 | 5 | 19,592 | Doug Davis | Aaron Harang | Francisco Cordero | Clay Zavada | | 343 | 386 | -43 |
| 2009-07-03 | @ COL | 80 | L 0-5 | 35-45 | 5 | 49,026 | Max Scherzer | Jorge de la Rosa | Jorge de la Rosa | Max Scherzer | | 343 | 391 | -48 |
| 2009-07-04 | @ COL | 81 | W 11-7 | 35-46 | 5 | 49,096 | Yusmeiro Petit | Aaron Cook | Scott Schoeneweis | Joel Peralta | Chad Qualls | 354 | 398 | -44 |
| 2009-07-05 | @ COL | 82 | W 4-3 | 36-46 | 5 | 27,547 | Dan Haren | Ubaldo Jimenez | Dan Haren | Ubaldo Jimenez | Chad Qualls | 358 | 401 | -43 |
| 2009-07-06 | vs SDN | 83 | W 6-5 | 37-46 | 5 | 17,528 | Jon Garland | Walter Silva | Jon Rauch | Cla Meredith | | 364 | 406 | -42 |
| 2009-07-07 | vs SDN | 84 | W 4-3 | 38-46 | 5 | 18,619 | Doug Davis | Kevin Correia | Doug Davis | Kevin Correia | Chad Qualls | 368 | 409 | -41 |
| 2009-07-08 | vs SDN | 85 | W 6-2 | 39-46 | 5 | 20,791 | Max Scherzer | Chad Gaudin | Clay Zavada | Greg Burke | | 374 | 411 | -37 |
| 2009-07-09 | vs FLO | 86 | L 7-14 | 40-46 | 5 | 21,558 | Yusmeiro Petit | Andrew Miller | Kiko Calero | Scott Schoeneweis | | 381 | 425 | -44 |
| 2009-07-10 | vs FLO | 87 | W 8-0 | 41-46 | 5 | 21,307 | Dan Haren | Ricky Nolasco | Dan Haren | Ricky Nolasco | | 389 | 425 | -36 |
| 2009-07-11 | vs FLO | 88 | W 5-1 | 42-46 | 4 | 29,477 | Jon Garland | Sean West | Jon Garland | Sean West | | 394 | 426 | -32 |
| 2009-07-12 | vs FLO | 89 | L 1-8 | 42-47 | 4 | 28,617 | Doug Davis | Josh Johnson | Josh Johnson | Doug Davis | | 395 | 434 | -39 |
| 2009-07-17 | @ SLN | 90 | L 1-6 | 42-48 | 4 | 44,781 | Jon Garland | Chris Carpenter | Chris Carpenter | Jon Garland | | 396 | 440 | -44 |
| 2009-07-18 | @ SLN | 91 | W 4-2 | 43-48 | 4 | 45,267 | Dan Haren | Adam Wainwright | Dan Haren | Adam Wainwright | Chad Qualls | 400 | 442 | -42 |
| 2009-07-19 | @ SLN | 92 | L 1-2 | 43-49 | 4 | 41,759 | Yusmeiro Petit | Joel Pineiro | Joel Pineiro | Yusmeiro Petit | Ryan Franklin | 401 | 444 | -43 |
| 2009-07-20 | @ COL | 93 | L 6-10 | 44-49 | 4 | 40,444 | Doug Davis | Jorge de la Rosa | Jorge de la Rosa | Doug Davis | | 407 | 454 | -47 |
| 2009-07-21 | @ COL | 94 | W 6-5 | 45-49 | 4 | 30,248 | Max Scherzer | Aaron Cook | Juan Gutierrez | Juan Rincon | Chad Qualls | 413 | 459 | -46 |
| 2009-07-22 | @ COL | 95 | L 3-4 | 45-50 | 4 | 30,451 | Jon Garland | Ubaldo Jimenez | Juan Rincon | Scott Schoeneweis | Huston Street | 416 | 463 | -47 |
| 2009-07-23 | vs PIT | 96 | W 11-4 | 45-51 | 4 | 24,008 | Dan Haren | Charlie Morton | Juan Gutierrez | Evan Meek | | 427 | 467 | -40 |
| 2009-07-24 | vs PIT | 97 | L 3-10 | 46-51 | 4 | 24,911 | Yusmeiro Petit | Zach Duke | Zach Duke | Yusmeiro Petit | | 430 | 477 | -47 |
| 2009-07-25 | vs PIT | 98 | W 7-0 | 47-51 | 4 | 26,037 | Doug Davis | Ross Ohlendorf | Doug Davis | Ross Ohlendorf | | 437 | 477 | -40 |
| 2009-07-26 | vs PIT | 99 | W 9-0 | 48-51 | 4 | 27,507 | Max Scherzer | Virgil Vasquez | Max Scherzer | Virgil Vasquez | | 446 | 477 | -31 |
| 2009-07-27 | vs PHI | 100 | L 2-6 | 48-52 | 4 | 20,565 | Jon Garland | Jamie Moyer | Jamie Moyer | Jon Garland | | 448 | 483 | -35 |
| 2009-07-28 | vs PHI | 101 | L 3-4 | 48-53 | 4 | 25,044 | Dan Haren | Cole Hamels | Cole Hamels | Dan Haren | Brad Lidge | 451 | 487 | -36 |
| 2009-07-29 | vs PHI | 102 | W 4-0 | 49-53 | 4 | 22,952 | Yusmeiro Petit | J.A. Happ | Yusmeiro Petit | J.A. Happ | | 455 | 487 | -32 |
| 2009-07-31 | @ NYN | 103 | W 3-2 | 50-53 | 4 | 38,241 | Doug Davis | Livan Hernandez | Esmerling Vasquez | Sean Green | Chad Qualls | 458 | 489 | -31 |
| 2009-08-01 | @ NYN | 104 | L 6-9 | 50-54 | 4 | 39,574 | Max Scherzer | Oliver Perez | Pedro Feliciano | Clay Zavada | Francisco Rodriguez | 464 | 498 | -34 |
| 2009-08-02 | @ NYN | 105 | W 5-2 | 51-54 | 4 | 38,374 | Jon Garland | Mike Pelfrey | Jon Garland | Mike Pelfrey | | 469 | 500 | -31 |
| 2009-08-03 | @ NYN | 106 | W 6-5 | 52-54 | 4 | 39,320 | Dan Haren | Nelson Figueroa | Dan Haren | Nelson Figueroa | Chad Qualls | 475 | 505 | -30 |
| 2009-08-04 | @ PIT | 107 | W 6-0 | 53-54 | 4 | 11,294 | Yusmeiro Petit | Zach Duke | Yusmeiro Petit | Zach Duke | | 481 | 505 | -24 |
| 2009-08-05 | @ PIT | 108 | W 4-3 | 54-54 | 4 | 11,470 | Doug Davis | Ross Ohlendorf | Doug Davis | Joel Hanrahan | Chad Qualls | 485 | 508 | -23 |
| 2009-08-06 | @ PIT | 109 | W 11-6 | 54-55 | 4 | 17,311 | Max Scherzer | Kevin Hart | Jon Rauch | Steven Jackson | | 496 | 514 | -18 |
| 2009-08-07 | @ WAS | 110 | L 6-7 | 54-56 | 4 | 22,674 | Jon Garland | Collin Balester | Jason Bergmann | Juan Gutierrez | Mike MacDougal | 502 | 521 | -19 |
| 2009-08-08 | @ WAS | 111 | L 2-5 | 54-57 | 4 | 24,551 | Dan Haren | Garrett Mock | Garrett Mock | Dan Haren | Jorge Sosa | 504 | 526 | -22 |
| 2009-08-09 | @ WAS | 112 | L 2-9 | 54-58 | 4 | 19,938 | Yusmeiro Petit | J.D. Martin | J.D. Martin | Yusmeiro Petit | Jorge Sosa | 506 | 535 | -29 |
| 2009-08-10 | vs NYN | 113 | W 7-4 | 55-58 | 4 | 23,069 | Doug Davis | Mike Pelfrey | Doug Davis | Mike Pelfrey | | 513 | 539 | -26 |
| 2009-08-11 | vs NYN | 114 | W 6-2 | 56-58 | 4 | 24,576 | Max Scherzer | Livan Hernandez | Max Scherzer | Livan Hernandez | | 519 | 541 | -22 |
| 2009-08-12 | vs NYN | 115 | L 4-6 | 56-59 | 4 | 22,320 | Jon Garland | Oliver Perez | Pedro Feliciano | Jon Rauch | Francisco Rodriguez | 523 | 547 | -24 |
| 2009-08-14 | vs LAN | 116 | W 4-1 | 57-59 | 4 | 31,573 | Dan Haren | Clayton Kershaw | Dan Haren | Clayton Kershaw | Chad Qualls | 527 | 548 | -21 |
| 2009-08-15 | vs LAN | 117 | W 4-3 | 58-59 | 4 | 42,058 | Doug Davis | Hiroki Kuroda | Chad Qualls | Ramon Troncoso | | 531 | 551 | -20 |
| 2009-08-16 | vs LAN | 118 | L 3-9 | 58-60 | 5 | 34,012 | Yusmeiro Petit | Randy Wolf | Randy Wolf | Yusmeiro Petit | | 534 | 560 | -26 |
| 2009-08-17 | @ ATL | 119 | L 4-9 | 58-61 | 4 | 23,668 | Max Scherzer | Tommy Hanson | Tommy Hanson | Max Scherzer | | 538 | 569 | -31 |
| 2009-08-18 | @ PHI | 120 | L 1-5 | 58-62 | 4 | 45,186 | Jon Garland | Pedro Martinez | Jamie Moyer | Jon Garland | | 539 | 574 | -35 |
| 2009-08-19 | @ PHI | 121 | L 1-8 | 58-63 | 4 | 45,356 | Dan Haren | Cliff Lee | Cliff Lee | Dan Haren | | 540 | 582 | -42 |
| 2009-08-20 | @ PHI | 122 | L 3-12 | 59-63 | 4 | 45,172 | Doug Davis | Joe Blanton | Joe Blanton | Doug Davis | | 543 | 594 | -51 |
| 2009-08-21 | @ HOU | 123 | L 0-1 | 59-64 | 4 | 30,032 | Yusmeiro Petit | Roy Oswalt | Roy Oswalt | Yusmeiro Petit | Jose Valverde | 543 | 595 | -52 |
| 2009-08-22 | @ HOU | 124 | L 2-4 | 59-65 | 4 | 39,412 | Max Scherzer | Brian Moehler | Brian Moehler | Max Scherzer | LaTroy Hawkins | 545 | 599 | -54 |
| 2009-08-23 | @ HOU | 125 | W 7-5 | 60-65 | 4 | 30,612 | Jon Garland | Bud Norris | Jon Garland | Bud Norris | Chad Qualls | 552 | 604 | -52 |
| 2009-08-25 | @ SFN | 126 | L 4-5 | 60-66 | 4 | 37,492 | Dan Haren | Matt Cain | Jeremy Affeldt | Jon Rauch | Sergio Romo | 556 | 609 | -53 |
| 2009-08-26 | @ SFN | 127 | L 3-4 | 60-67 | 4 | 27,645 | Doug Davis | Jonathan Sanchez | Justin Miller | Chad Qualls | Brandon Medders | 559 | 613 | -54 |
| 2009-08-27 | @ SFN | 128 | W 11-0 | 61-67 | 4 | 28,575 | Yusmeiro Petit | Joe Martinez | Yusmeiro Petit | Joe Martinez | | 570 | 613 | -43 |
| 2009-08-28 | vs HOU | 129 | W 14-7 | 61-68 | 4 | 26,190 | Max Scherzer | Yorman Bazardo | Max Scherzer | Yorman Bazardo | | 584 | 620 | -36 |
| 2009-08-29 | vs HOU | 130 | W 9-0 | 62-68 | 4 | 37,190 | Jon Garland | Bud Norris | Jon Garland | Bud Norris | | 593 | 620 | -27 |
| 2009-08-30 | vs HOU | 131 | W 4-3 | 63-68 | 4 | 29,062 | Dan Haren | Wandy Rodriguez | Dan Haren | Wandy Rodriguez | Chad Qualls | 597 | 623 | -26 |
| 2009-08-31 | @ LAN | 132 | W 5-3 | 64-68 | 4 | 45,211 | Doug Davis | Randy Wolf | Esmerling Vasquez | James McDonald | Juan Gutierrez | 602 | 626 | -24 |
| 2009-09-01 | @ LAN | 133 | L 3-4 | 64-69 | 4 | 45,433 | Yusmeiro Petit | Vicente Padilla | Ronald Belisario | Leo Rosales | Jonathan Broxton | 605 | 630 | -25 |
| 2009-09-02 | @ LAN | 134 | W 4-1 | 65-69 | 4 | 45,076 | Max Scherzer | Chad Billingsley | Max Scherzer | Chad Billingsley | Juan Gutierrez | 609 | 631 | -22 |
| 2009-09-03 | @ LAN | 135 | L 2-4 | 65-70 | 4 | 45,365 | Billy Buckner | Jon Garland | Jon Garland | Billy Buckner | Jonathan Broxton | 611 | 635 | -24 |
| 2009-09-04 | @ COL | 136 | L 4-5 | 65-71 | 4 | 31,401 | Dan Haren | Jason Hammel | Rafael Betancourt | Blaine Boyer | Franklin Morales | 615 | 640 | -25 |
| 2009-09-05 | @ COL | 137 | L 1-4 | 65-72 | 4 | 39,297 | Doug Davis | Jose Contreras | Jose Contreras | Doug Davis | Franklin Morales | 616 | 644 | -28 |
| 2009-09-06 | @ COL | 138 | L 5-13 | 66-72 | 4 | 35,192 | Yusmeiro Petit | Jorge de la Rosa | Jorge de la Rosa | Yusmeiro Petit | | 621 | 657 | -36 |
| 2009-09-07 | vs LAN | 139 | L 2-7 | 66-73 | 4 | 28,317 | Max Scherzer | Vicente Padilla | Vicente Padilla | Max Scherzer | Jonathan Broxton | 623 | 664 | -41 |
| 2009-09-08 | vs LAN | 140 | L 4-5 | 66-74 | 4 | 22,589 | Billy Buckner | Chad Billingsley | James McDonald | Daniel Schlereth | Jonathan Broxton | 627 | 669 | -42 |
| 2009-09-09 | vs LAN | 141 | W 4-3 | 67-74 | 4 | 20,025 | Dan Haren | Jon Garland | Juan Gutierrez | Ramon Troncoso | | 631 | 672 | -41 |
| 2009-09-11 | vs MIL | 142 | L 3-6 | 67-75 | 4 | 19,945 | Doug Davis | Braden Looper | Braden Looper | Doug Davis | Trevor Hoffman | 634 | 678 | -44 |
| 2009-09-12 | vs MIL | 143 | L 2-9 | 67-76 | 4 | 31,369 | Kevin Mulvey | David Bush | David Bush | Kevin Mulvey | | 636 | 687 | -51 |
| 2009-09-13 | vs MIL | 144 | L 3-5 | 67-77 | 5 | 21,453 | Max Scherzer | Chris Narveson | Carlos Villanueva | Daniel Schlereth | Trevor Hoffman | 639 | 692 | -53 |
| 2009-09-14 | @ SDN | 145 | W 4-2 | 68-77 | 4 | 20,265 | Billy Buckner | Kevin Correia | Clay Zavada | Adam Russell | Juan Gutierrez | 643 | 694 | -51 |
| 2009-09-15 | @ SDN | 146 | W 4-2 | 69-77 | 4 | 14,790 | Dan Haren | Wade LeBlanc | Dan Haren | Heath Bell | Juan Gutierrez | 647 | 696 | -49 |
| 2009-09-16 | @ SDN | 147 | L 5-6 | 69-78 | 4 | 14,377 | Doug Davis | Edward Mujica | Heath Bell | Yusmeiro Petit | | 652 | 702 | -50 |
| 2009-09-18 | vs COL | 148 | W 7-5 | 70-78 | 4 | 34,231 | Kevin Mulvey | Jason Marquis | Leo Rosales | Randy Flores | Juan Gutierrez | 659 | 707 | -48 |
| 2009-09-19 | vs COL | 149 | L 4-10 | 71-78 | 4 | 29,466 | Max Scherzer | Jason Hammel | Jason Hammel | Max Scherzer | | 663 | 717 | -54 |
| 2009-09-20 | vs COL | 150 | L 1-5 | 71-79 | 4 | 29,397 | Dan Haren | Ubaldo Jimenez | Ubaldo Jimenez | Dan Haren | | 664 | 722 | -58 |
| 2009-09-21 | vs SFN | 151 | L 4-5 | 71-80 | 4 | 25,485 | Billy Buckner | Barry Zito | Sergio Romo | Esmerling Vasquez | Brian Wilson | 668 | 727 | -59 |
| 2009-09-22 | vs SFN | 152 | W 10-8 | 71-81 | 4 | 25,591 | Doug Davis | Matt Cain | Doug Davis | Matt Cain | | 678 | 735 | -57 |
| 2009-09-23 | vs SFN | 153 | L 2-5 | 71-82 | 5 | 25,851 | Kevin Mulvey | Jonathan Sanchez | Jonathan Sanchez | Kevin Mulvey | Brian Wilson | 680 | 740 | -60 |
| 2009-09-25 | vs SDN | 154 | L 0-4 | 71-83 | 5 | 29,719 | Max Scherzer | Kevin Correia | Kevin Correia | Max Scherzer | | 680 | 744 | -64 |
| 2009-09-26 | vs SDN | 155 | W 8-5 | 72-83 | 5 | 39,332 | Dan Haren | Wade LeBlanc | Daniel Schlereth | Luke Gregerson | Juan Gutierrez | 688 | 749 | -61 |
| 2009-09-27 | vs SDN | 156 | W 7-4 | 73-83 | 5 | 30,018 | Billy Buckner | Edward Mujica | Billy Buckner | Edward Mujica | Juan Gutierrez | 695 | 753 | -58 |
| 2009-09-29 | @ SFN | 157 | L 4-8 | 73-84 | 5 | 28,039 | Doug Davis | Jonathan Sanchez | Jonathan Sanchez | Doug Davis | | 699 | 761 | -62 |
| 2009-09-30 | @ SFN | 158 | L 1-4 | 73-85 | 5 | 29,473 | Kevin Mulvey | Brad Penny | Brad Penny | Kevin Mulvey | | 700 | 765 | -65 |
| 2009-10-01 | @ SFN | 159 | L 3-7 | 73-86 | 5 | 27,941 | Dan Haren | Tim Lincecum | Tim Lincecum | Dan Haren | | 703 | 772 | -69 |
| 2009-10-02 | @ CHN | 160 | W 12-3 | 73-87 | 5 | 33,786 | Billy Buckner | Tom Gorzelanny | Billy Buckner | Tom Gorzelanny | | 715 | 775 | -60 |
| 2009-10-03 | @ CHN | 161 | L 0-5 | 73-88 | 5 | 39,138 | Daniel Cabrera | Randy Wells | Randy Wells | Daniel Cabrera | | 715 | 780 | -65 |
| 2009-10-04 | @ CHN | 162 | W 5-2 | 74-88 | 5 | 39,154 | Doug Davis | Ryan Dempster | Doug Davis | Ryan Dempster | Juan Gutierrez | 720 | 782 | -62 |