| 31 | Cliff Lee | - | 2 | 31 | 31 | 223.1 | 2.54 | 1.11 | 8.62 | 0.48 | 1.37 | 6.85 | 0.20 | 0.87 | 23 | 5 | 847 | .253 | 891 | 3.67 | 31.1 | 68.9 | 7.8 |
| 36 | Paul Byrd | - | 27 | 22 | 22 | 131.0 | 4.53 | 1.30 | 10.03 | 1.58 | 1.65 | 3.85 | 0.43 | 0.62 | 10 | 5 | 517 | .282 | 553 | 3.26 | 32.4 | 67.6 | 5.8 |
| 52 | C.C. Sabathia | - | 41 | 18 | 18 | 122.1 | 3.83 | 1.23 | 8.61 | 0.96 | 2.50 | 9.05 | 0.28 | 0.87 | 0 | 0 | 0 | -- | 0 | -- | 34.2 | 65.8 | 13.2 |
| 45 | Jeremy Sowers | - | - | 22 | 22 | 121.0 | 5.58 | 1.49 | 10.49 | 1.34 | 2.90 | 4.76 | 0.61 | 0.79 | 7 | 3 | 484 | .291 | 533 | 3.81 | 37.0 | 63.0 | 5.8 |
| 55 | Roberto Hernandez | - | 85 | 22 | 22 | 120.2 | 5.44 | 1.62 | 9.40 | 0.52 | 5.22 | 4.33 | 1.21 | 1.83 | 9 | 9 | 465 | .271 | 549 | 3.70 | 39.0 | 61.0 | 7.1 |
| 32 | Aaron Laffey | - | - | 16 | 16 | 93.2 | 4.23 | 1.43 | 9.90 | 0.96 | 2.98 | 4.13 | 0.72 | 1.10 | 10 | 9 | 367 | .281 | 409 | 3.66 | 39.5 | 60.5 | 6.5 |
| 53 | Rafael Perez | - | 59 | 73 | 0 | 76.1 | 3.54 | 1.18 | 7.90 | 0.94 | 2.71 | 10.14 | 0.27 | 1.40 | 0 | 2 | 286 | .234 | 313 | 3.79 | 33.0 | 67.0 | 13.6 |
| 63 | Rafael Betancourt | - | 83 | 69 | 0 | 71.0 | 5.07 | 1.42 | 9.63 | 1.39 | 3.17 | 8.11 | 0.39 | 0.46 | 0 | 0 | 275 | .276 | 309 | 3.95 | 34.1 | 65.9 | 13.4 |
| 50 | Jensen Lewis | - | 71 | 51 | 0 | 66.0 | 3.82 | 1.44 | 9.27 | 1.09 | 3.68 | 7.09 | 0.52 | 0.59 | 0 | 5 | 256 | .266 | 292 | 3.96 | 36.1 | 63.9 | 8.0 |
| 30 | Masahide Kobayashi | - | 80 | 57 | 0 | 55.2 | 4.53 | 1.42 | 10.51 | 1.29 | 2.26 | 5.66 | 0.40 | 1.02 | 0 | 1 | 227 | .286 | 244 | 3.61 | 37.5 | 62.5 | 7.5 |
| 57 | Zach Jackson | - | - | 9 | 9 | 54.2 | 5.60 | 1.43 | 10.54 | 1.15 | 2.30 | 4.94 | 0.47 | 1.12 | 4 | 3 | 219 | .292 | 238 | 3.48 | 38.5 | 61.5 | 6.5 |
| 49 | Edward Mujica | - | - | 33 | 0 | 38.2 | 6.75 | 1.45 | 10.71 | 1.16 | 2.33 | 6.28 | 0.37 | 0.44 | 0 | 1 | 153 | .301 | 168 | 3.63 | 34.3 | 65.7 | 8.9 |
| 37 | Jake Westbrook | - | - | 5 | 5 | 34.2 | 3.12 | 1.15 | 8.57 | 1.30 | 1.82 | 4.93 | 0.37 | 1.38 | 4 | 1 | 129 | .256 | 139 | 3.66 | 36.9 | 63.1 | 7.7 |
| 27 | Anthony Reyes | - | - | 6 | 6 | 34.1 | 1.83 | 1.25 | 8.13 | 0.52 | 3.15 | 3.93 | 0.80 | 0.87 | 4 | 1 | 128 | .242 | 142 | 3.65 | 35.8 | 64.2 | 6.9 |
| 34 | Juan Rincon | - | - | 23 | 0 | 27.1 | 5.60 | 1.54 | 11.20 | 0.99 | 2.63 | 6.26 | 0.42 | 0.79 | 0 | 1 | 112 | .304 | 121 | 4.01 | 37.9 | 62.1 | 8.5 |
| 46 | Scott Lewis | - | - | 4 | 4 | 24.0 | 2.63 | 1.08 | 7.50 | 1.50 | 2.25 | 5.63 | 0.40 | 0.62 | 2 | 0 | 90 | .222 | 97 | 3.95 | 33.4 | 66.6 | 8.1 |
| 56 | Matt Ginter | - | - | 4 | 4 | 21.0 | 5.14 | 1.33 | 10.71 | 1.29 | 1.29 | 5.14 | 0.25 | 0.76 | 1 | 0 | 83 | .301 | 87 | 3.66 | 37.4 | 62.6 | 5.0 |
| 40 | Tom Mastny | - | - | 14 | 1 | 20.0 | 10.80 | 1.95 | 12.60 | 2.70 | 4.95 | 8.55 | 0.58 | 0.49 | 0 | 0 | 88 | .318 | 100 | 3.80 | 41.8 | 58.2 | 8.9 |
| 44 | Jorge Julio | - | - | 15 | 0 | 17.2 | 5.60 | 1.64 | 9.17 | 1.53 | 5.60 | 7.64 | 0.73 | 0.49 | 0 | 0 | 65 | .277 | 78 | 3.91 | 42.3 | 57.7 | 12.8 |
| 47 | Joe Borowski | - | 91 | 18 | 0 | 16.2 | 7.56 | 1.92 | 12.96 | 2.16 | 4.32 | 4.86 | 0.89 | 0.33 | 0 | 0 | 72 | .333 | 82 | 3.63 | 36.2 | 63.8 | 6.4 |
| 39 | Scott Elarton | - | - | 8 | 0 | 15.1 | 3.52 | 1.63 | 9.39 | -- | 5.28 | 8.80 | 0.60 | 0.84 | 0 | 0 | 61 | .262 | 70 | 3.96 | 39.7 | 60.3 | 7.2 |
| 26 | Bryan Bullington | - | - | 3 | 2 | 14.2 | 4.91 | 1.16 | 9.20 | 2.45 | 1.23 | 7.36 | 0.17 | 1.14 | 0 | 1 | 56 | .268 | 60 | 3.72 | 31.8 | 68.2 | 12.6 |
| 58 | Brendan Donnelly | - | - | 15 | 0 | 13.2 | 8.56 | 2.20 | 13.17 | 1.32 | 6.59 | 5.27 | 1.25 | 0.56 | 0 | 0 | 56 | .357 | 69 | 3.62 | 40.0 | 60.0 | 6.4 |
| 58 | Craig Breslow | - | - | 7 | 0 | 8.1 | 3.24 | 1.80 | 10.80 | 1.08 | 5.40 | 7.56 | 0.71 | 0.87 | 0 | 0 | 0 | -- | 0 | -- | 40.8 | 59.2 | 7.9 |
| 27 | Rick Bauer | - | - | 4 | 0 | 6.0 | 13.50 | 2.17 | 15.00 | 1.50 | 4.50 | 6.00 | 0.75 | 0.44 | 0 | 0 | 27 | .370 | 30 | 3.93 | 35.6 | 64.4 | 8.5 |
| 56 | Rich Rundles | - | - | 8 | 0 | 5.0 | 1.80 | 1.60 | 9.00 | -- | 5.40 | 10.80 | 0.50 | 1.17 | 0 | 0 | 19 | .263 | 22 | 4.68 | 37.9 | 62.1 | 5.8 |
| 59 | Jon Meloan | - | - | 2 | 0 | 2.0 | 0.00 | 0.50 | 0.00 | -- | 4.50 | 9.00 | 0.50 | 0.50 | 0 | 0 | 5 | .000 | 6 | 4.33 | 46.2 | 53.8 | 11.5 |
| 54 | Brian Slocum | - | - | 2 | 0 | 2.0 | 27.00 | 4.00 | 36.00 | 9.00 | 0.00 | 4.50 | 0.00 | 0.30 | 0 | 1 | 13 | .615 | 15 | 3.33 | 34.0 | 66.0 | 10.0 |