| 2008-03-30 | vs ATL | 1 | W 3-2 | 1-0 | 1 | 39,389 | Odalis Perez | Tim Hudson | Jon Rauch | Peter Moylan | | 3 | 2 | 1 |
| 2008-03-31 | @ PHI | 2 | W 11-6 | 2-0 | 2 | 44,553 | Matt Chico | Brett Myers | Saul Rivera | Tom Gordon | | 14 | 8 | 6 |
| 2008-04-02 | @ PHI | 3 | W 1-0 | 3-0 | 1 | 44,986 | Tim Redding | Cole Hamels | Tim Redding | Cole Hamels | Jon Rauch | 15 | 8 | 7 |
| 2008-04-03 | @ PHI | 4 | L 7-8 | 3-1 | 1 | 25,831 | Jason Bergmann | Jamie Moyer | Clay Condrey | Jesus Colome | | 22 | 16 | 6 |
| 2008-04-04 | @ SLN | 5 | L 4-5 | 3-2 | 2 | 37,191 | Odalis Perez | Braden Looper | Braden Looper | Odalis Perez | Jason Isringhausen | 26 | 21 | 5 |
| 2008-04-05 | @ SLN | 6 | L 4-5 | 3-3 | 3 | 41,463 | Matt Chico | Adam Wainwright | Adam Wainwright | Matt Chico | Randy Flores | 30 | 26 | 4 |
| 2008-04-06 | @ SLN | 7 | L 0-3 | 3-4 | 3 | 41,912 | John Lannan | Kyle Lohse | Kyle Lohse | John Lannan | Jason Isringhausen | 30 | 29 | 1 |
| 2008-04-07 | vs FLO | 8 | L 7-10 | 3-5 | 5 | 20,487 | Tim Redding | Andrew Miller | Renyel Pinto | Tim Redding | Kevin Gregg | 37 | 39 | -2 |
| 2008-04-09 | vs FLO | 9 | L 4-10 | 3-6 | 5 | 23,340 | Jason Bergmann | Scott Olsen | Scott Olsen | Jason Bergmann | | 41 | 49 | -8 |
| 2008-04-10 | vs FLO | 10 | L 3-4 | 3-7 | 5 | 24,549 | Odalis Perez | Mark Hendrickson | Mark Hendrickson | Odalis Perez | Kevin Gregg | 44 | 53 | -9 |
| 2008-04-11 | vs ATL | 11 | L 0-3 | 3-8 | 5 | 28,051 | Matt Chico | Tim Hudson | Tim Hudson | Matt Chico | Peter Moylan | 44 | 56 | -12 |
| 2008-04-12 | vs ATL | 12 | L 2-10 | 3-9 | 5 | 32,532 | John Lannan | John Smoltz | John Smoltz | John Lannan | | 46 | 66 | -20 |
| 2008-04-13 | vs ATL | 13 | W 5-4 | 4-9 | 5 | 29,151 | Tim Redding | Tom Glavine | Tim Redding | Tom Glavine | Jon Rauch | 51 | 70 | -19 |
| 2008-04-15 | @ NYN | 14 | L 0-6 | 4-10 | 5 | 46,567 | Odalis Perez | Mike Pelfrey | Mike Pelfrey | Odalis Perez | | 51 | 76 | -25 |
| 2008-04-16 | @ NYN | 15 | L 2-5 | 4-11 | 5 | 46,106 | Matt Chico | John Maine | John Maine | Matt Chico | Billy Wagner | 53 | 81 | -28 |
| 2008-04-17 | @ NYN | 16 | L 2-3 | 4-12 | 5 | 47,785 | John Lannan | Nelson Figueroa | Jorge Sosa | Joel Hanrahan | | 55 | 84 | -29 |
| 2008-04-18 | @ FLO | 17 | W 6-4 | 5-12 | 5 | 13,279 | Tim Redding | Andrew Miller | Tim Redding | Justin Miller | Jon Rauch | 61 | 88 | -27 |
| 2008-04-19 | @ FLO | 18 | L 5-6 | 5-13 | 5 | 18,944 | Shawn Hill | Burke Badenhop | Kevin Gregg | Saul Rivera | | 66 | 94 | -28 |
| 2008-04-20 | @ FLO | 19 | L 1-6 | 5-14 | 5 | 11,635 | Odalis Perez | Scott Olsen | Scott Olsen | Luis Ayala | | 67 | 100 | -33 |
| 2008-04-21 | @ ATL | 20 | L 3-7 | 5-15 | 5 | 16,706 | Matt Chico | Tim Hudson | Tim Hudson | Matt Chico | | 70 | 107 | -37 |
| 2008-04-22 | @ ATL | 21 | W 6-0 | 6-15 | 5 | 23,482 | John Lannan | John Smoltz | John Lannan | John Smoltz | | 76 | 107 | -31 |
| 2008-04-23 | vs NYN | 22 | L 2-7 | 6-16 | 5 | 32,780 | Tim Redding | Johan Santana | Johan Santana | Tim Redding | | 78 | 114 | -36 |
| 2008-04-24 | vs NYN | 23 | W 10-5 | 7-16 | 5 | 29,750 | Shawn Hill | Oliver Perez | Mike O'Connor | Oliver Perez | | 88 | 119 | -31 |
| 2008-04-25 | vs CHN | 24 | W 5-3 | 8-16 | 5 | 35,154 | Odalis Perez | Ryan Dempster | Jon Rauch | Bob Howry | | 93 | 122 | -29 |
| 2008-04-26 | vs CHN | 25 | L 0-7 | 8-17 | 5 | 35,188 | Matt Chico | Carlos Zambrano | Carlos Zambrano | Matt Chico | | 93 | 129 | -36 |
| 2008-04-27 | vs CHN | 26 | W 2-0 | 9-17 | 5 | 33,795 | John Lannan | Ted Lilly | John Lannan | Ted Lilly | Jon Rauch | 95 | 129 | -34 |
| 2008-04-29 | vs ATL | 27 | W 6-3 | 10-17 | 5 | 25,285 | Tim Redding | Tom Glavine | Saul Rivera | Blaine Boyer | Jon Rauch | 101 | 132 | -31 |
| 2008-04-30 | vs ATL | 28 | W 3-2 | 11-17 | 5 | 29,473 | Shawn Hill | Jair Jurrjens | Saul Rivera | Manny Acosta | | 104 | 134 | -30 |
| 2008-05-01 | vs PIT | 29 | W 3-2 | 12-17 | 5 | 24,723 | Odalis Perez | Zach Duke | Luis Ayala | John Grabow | Jon Rauch | 107 | 136 | -29 |
| 2008-05-02 | vs PIT | 30 | L 4-11 | 12-18 | 5 | 26,001 | John Lannan | Phil Dumatrait | Damaso Marte | John Lannan | | 111 | 147 | -36 |
| 2008-05-03 | vs PIT | 31 | W 9-8 | 13-18 | 5 | 34,128 | Matt Chico | Paul Maholm | Jesus Colome | Paul Maholm | Jon Rauch | 120 | 155 | -35 |
| 2008-05-04 | vs PIT | 32 | W 5-2 | 14-18 | 5 | 30,564 | Tim Redding | Ian Snell | Tim Redding | Ian Snell | | 125 | 157 | -32 |
| 2008-05-06 | @ HOU | 33 | L 5-6 | 14-19 | 5 | 30,335 | Shawn Hill | Shawn Chacon | Doug Brocail | Luis Ayala | Jose Valverde | 130 | 163 | -33 |
| 2008-05-07 | @ HOU | 34 | L 3-4 | 14-20 | 5 | 30,432 | Odalis Perez | Roy Oswalt | Jose Valverde | Joel Hanrahan | | 133 | 167 | -34 |
| 2008-05-08 | @ HOU | 35 | W 8-3 | 15-20 | 5 | 33,433 | John Lannan | Brandon Backe | John Lannan | Brandon Backe | | 141 | 170 | -29 |
| 2008-05-09 | vs FLO | 36 | L 3-7 | 15-21 | 5 | 23,379 | Tim Redding | Ricky Nolasco | Ricky Nolasco | Tim Redding | | 144 | 177 | -33 |
| 2008-05-10 | vs FLO | 37 | L 0-11 | 15-22 | 5 | 28,663 | Mike O'Connor | Andrew Miller | Andrew Miller | Mike O'Connor | | 144 | 188 | -44 |
| 2008-05-11 | vs FLO | 38 | L 4-5 | 15-23 | 5 | 25,871 | Shawn Hill | Scott Olsen | Logan Kensing | Luis Ayala | Kevin Gregg | 148 | 193 | -45 |
| 2008-05-12 | @ NYN | 39 | W 10-4 | 16-23 | 5 | 45,321 | Odalis Perez | Nelson Figueroa | Odalis Perez | Nelson Figueroa | | 158 | 197 | -39 |
| 2008-05-13 | @ NYN | 40 | L 3-6 | 16-24 | 5 | 46,618 | John Lannan | John Maine | John Maine | John Lannan | Billy Wagner | 161 | 203 | -42 |
| 2008-05-14 | @ NYN | 41 | W 5-3 | 17-24 | 5 | 48,529 | Tim Redding | Claudio Vargas | Tim Redding | Claudio Vargas | Jon Rauch | 166 | 206 | -40 |
| 2008-05-15 | @ NYN | 42 | W 1-0 | 18-24 | 5 | 51,769 | Jason Bergmann | Mike Pelfrey | Jason Bergmann | Mike Pelfrey | Jon Rauch | 167 | 206 | -39 |
| 2008-05-16 | @ BAL | 43 | L 3-5 | 18-25 | 5 | 29,266 | Shawn Hill | Garrett Olson | Garrett Olson | Shawn Hill | George Sherrill | 170 | 211 | -41 |
| 2008-05-17 | @ BAL | 44 | L 5-6 | 18-26 | 5 | 32,662 | Odalis Perez | Brian Burres | Brian Burres | Odalis Perez | George Sherrill | 175 | 217 | -42 |
| 2008-05-18 | @ BAL | 45 | W 2-1 | 19-26 | 5 | 33,745 | John Lannan | Jeremy Guthrie | John Lannan | Jeremy Guthrie | Jon Rauch | 177 | 218 | -41 |
| 2008-05-19 | vs PHI | 46 | W 4-0 | 20-26 | 5 | 25,394 | Tim Redding | Brett Myers | Tim Redding | Brett Myers | | 181 | 218 | -37 |
| 2008-05-20 | vs PHI | 47 | L 0-1 | 20-27 | 5 | 28,105 | Jason Bergmann | Cole Hamels | Tom Gordon | Jon Rauch | Brad Lidge | 181 | 219 | -38 |
| 2008-05-21 | vs PHI | 48 | L 2-12 | 20-28 | 5 | 28,055 | Matt Chico | Jamie Moyer | Jamie Moyer | Matt Chico | Clay Condrey | 183 | 231 | -48 |
| 2008-05-23 | vs MIL | 49 | W 5-1 | 21-28 | 5 | 28,007 | Odalis Perez | Jeff Suppan | Brian Sanches | Jeff Suppan | | 188 | 232 | -44 |
| 2008-05-24 | vs MIL | 50 | L 2-5 | 21-29 | 5 | 30,029 | John Lannan | Seth McClung | Seth McClung | John Lannan | Salomon Torres | 190 | 237 | -47 |
| 2008-05-25 | vs MIL | 51 | W 7-6 | 22-29 | 5 | 35,567 | Tim Redding | Manny Parra | Jon Rauch | Guillermo Mota | | 197 | 243 | -46 |
| 2008-05-26 | vs MIL | 52 | L 3-4 | 22-30 | 5 | 28,552 | Jason Bergmann | Ben Sheets | Carlos Villanueva | Saul Rivera | Salomon Torres | 200 | 247 | -47 |
| 2008-05-27 | @ SDN | 53 | L 2-4 | 22-31 | 5 | 18,774 | Shawn Hill | Randy Wolf | Heath Bell | Charlie Manning | Trevor Hoffman | 202 | 251 | -49 |
| 2008-05-28 | @ SDN | 54 | W 6-4 | 23-31 | 5 | 19,201 | Odalis Perez | Shawn Estes | Odalis Perez | Shawn Estes | Jon Rauch | 208 | 255 | -47 |
| 2008-05-29 | @ SDN | 55 | L 2-5 | 23-32 | 5 | 25,021 | John Lannan | Wil Ledezma | Heath Bell | Saul Rivera | Trevor Hoffman | 210 | 260 | -50 |
| 2008-05-30 | @ ARI | 56 | W 7-4 | 24-32 | 5 | 25,391 | Tim Redding | Micah Owings | Joel Hanrahan | Micah Owings | Jon Rauch | 217 | 264 | -47 |
| 2008-05-31 | @ ARI | 57 | L 0-4 | 24-33 | 5 | 38,507 | Jason Bergmann | Brandon Webb | Brandon Webb | Jason Bergmann | | 217 | 268 | -51 |
| 2008-06-01 | @ ARI | 58 | L 0-5 | 24-34 | 5 | 28,249 | Shawn Hill | Dan Haren | Dan Haren | Shawn Hill | | 217 | 273 | -56 |
| 2008-06-03 | vs SLN | 59 | L 1-6 | 24-35 | 5 | 26,875 | Odalis Perez | Kyle Lohse | Kyle Lohse | Odalis Perez | | 218 | 279 | -61 |
| 2008-06-05 | vs SLN | 60 | L 1-4 | 25-36 | 5 | 27,264 | John Lannan | Todd Wellemeyer | Todd Wellemeyer | John Lannan | Ryan Franklin | 219 | 283 | -64 |
| 2008-06-05 | vs SLN | 61 | W 10-9 | 25-36 | 5 | 32,357 | Tim Redding | Mike Parisi | Brian Sanches | Ryan Franklin | | 229 | 292 | -63 |
| 2008-06-06 | vs SFN | 62 | L 1-10 | 25-37 | 5 | 25,987 | Jason Bergmann | Tim Lincecum | Tim Lincecum | Jason Bergmann | | 230 | 302 | -72 |
| 2008-06-07 | vs SFN | 63 | L 0-6 | 25-38 | 5 | 30,652 | Shawn Hill | Jonathan Sanchez | Jonathan Sanchez | Shawn Hill | | 230 | 308 | -78 |
| 2008-06-08 | vs SFN | 64 | L 3-6 | 25-39 | 5 | 30,224 | Garrett Mock | Barry Zito | Barry Zito | Garrett Mock | Brian Wilson | 233 | 314 | -81 |
| 2008-06-09 | vs SFN | 65 | L 2-3 | 25-40 | 5 | 26,209 | Tyler Clippard | Matt Cain | Matt Cain | Tyler Clippard | Brian Wilson | 235 | 317 | -82 |
| 2008-06-10 | @ PIT | 66 | W 7-6 | 26-40 | 5 | 12,957 | Tim Redding | Paul Maholm | Joel Hanrahan | Matt Capps | Jon Rauch | 242 | 323 | -81 |
| 2008-06-11 | @ PIT | 67 | L 1-3 | 26-41 | 5 | 15,439 | John Lannan | Ian Snell | Ian Snell | John Lannan | Matt Capps | 243 | 326 | -83 |
| 2008-06-12 | @ PIT | 68 | L 5-7 | 26-42 | 5 | 16,306 | Jason Bergmann | Tom Gorzelanny | Tom Gorzelanny | Jason Bergmann | Damaso Marte | 248 | 333 | -85 |
| 2008-06-13 | @ SEA | 69 | W 7-6 | 27-42 | 5 | 35,941 | Shawn Hill | R.A. Dickey | Shawn Hill | R.A. Dickey | Jon Rauch | 255 | 339 | -84 |
| 2008-06-14 | @ SEA | 70 | W 5-2 | 28-42 | 5 | 32,145 | Tyler Clippard | Erik Bedard | Tyler Clippard | Miguel Batista | Jon Rauch | 260 | 341 | -81 |
| 2008-06-15 | @ SEA | 71 | W 6-2 | 29-42 | 5 | 38,548 | Tim Redding | Jarrod Washburn | Jesus Colome | Mark Lowe | | 266 | 343 | -77 |
| 2008-06-17 | @ MIN | 72 | L 1-2 | 29-43 | 5 | 20,920 | John Lannan | Livan Hernandez | Livan Hernandez | John Lannan | Joe Nathan | 267 | 345 | -78 |
| 2008-06-18 | @ MIN | 73 | L 2-11 | 29-44 | 5 | 23,841 | Jason Bergmann | Kevin Slowey | Kevin Slowey | Jason Bergmann | | 269 | 356 | -87 |
| 2008-06-19 | @ MIN | 74 | L 3-9 | 29-45 | 5 | 24,793 | Shawn Hill | Glen Perkins | Glen Perkins | Shawn Hill | | 272 | 365 | -93 |
| 2008-06-20 | vs TEX | 75 | W 4-3 | 30-45 | 5 | 30,359 | Tim Redding | Kevin Millwood | Joel Hanrahan | Jamey Wright | | 276 | 368 | -92 |
| 2008-06-21 | vs TEX | 76 | L 3-13 | 30-46 | 5 | 32,975 | Garrett Mock | Kason Gabbard | Kason Gabbard | Garrett Mock | Luis Mendoza | 279 | 381 | -102 |
| 2008-06-22 | vs TEX | 77 | L 3-5 | 30-47 | 5 | 32,690 | John Lannan | Vicente Padilla | Vicente Padilla | Luis Ayala | C.J. Wilson | 282 | 386 | -104 |
| 2008-06-23 | vs ANA | 78 | L 2-3 | 30-48 | 5 | 24,805 | Jason Bergmann | John Lackey | John Lackey | Saul Rivera | Francisco Rodriguez | 284 | 389 | -105 |
| 2008-06-24 | vs ANA | 79 | L 3-8 | 30-49 | 5 | 28,531 | Shawn Hill | Jon Garland | Jon Garland | Shawn Hill | | 287 | 397 | -110 |
| 2008-06-25 | vs ANA | 80 | W 5-4 | 31-49 | 5 | 29,180 | Tim Redding | Ervin Santana | Jon Rauch | Scot Shields | | 292 | 401 | -109 |
| 2008-06-27 | vs BAL | 81 | W 4-2 | 32-49 | 5 | 35,830 | Odalis Perez | Daniel Cabrera | Joel Hanrahan | Daniel Cabrera | Jon Rauch | 296 | 403 | -107 |
| 2008-06-28 | vs BAL | 82 | L 1-9 | 32-50 | 5 | 39,479 | John Lannan | Garrett Olson | Garrett Olson | John Lannan | Lance Cormier | 297 | 412 | -115 |
| 2008-06-29 | vs BAL | 83 | W 3-2 | 33-50 | 5 | 39,824 | Jason Bergmann | Jeremy Guthrie | Joel Hanrahan | George Sherrill | | 300 | 414 | -114 |
| 2008-06-30 | @ FLO | 84 | L 5-6 | 33-51 | 5 | 10,888 | Tim Redding | Ryan Tucker | Kevin Gregg | Jon Rauch | | 305 | 420 | -115 |
| 2008-07-01 | @ FLO | 85 | W 9-6 | 34-51 | 5 | 12,166 | Collin Balester | Mark Hendrickson | Collin Balester | Mark Hendrickson | Jon Rauch | 314 | 426 | -112 |
| 2008-07-02 | @ FLO | 86 | L 2-4 | 34-52 | 5 | 23,624 | Odalis Perez | Ricky Nolasco | Ricky Nolasco | Charlie Manning | Kevin Gregg | 316 | 430 | -114 |
| 2008-07-03 | @ CIN | 87 | L 3-5 | 34-53 | 5 | 23,259 | John Lannan | Johnny Cueto | Johnny Cueto | Jesus Colome | Francisco Cordero | 319 | 435 | -116 |
| 2008-07-04 | @ CIN | 88 | L 0-3 | 34-54 | 5 | 22,626 | Jason Bergmann | Bronson Arroyo | Bronson Arroyo | Jason Bergmann | Francisco Cordero | 319 | 438 | -119 |
| 2008-07-05 | @ CIN | 89 | L 2-3 | 34-55 | 5 | 37,121 | Tim Redding | Josh Fogg | Francisco Cordero | Joel Hanrahan | | 321 | 441 | -120 |
| 2008-07-06 | @ CIN | 90 | L 5-6 | 34-56 | 5 | 28,814 | Collin Balester | Edinson Volquez | Edinson Volquez | Collin Balester | Francisco Cordero | 326 | 447 | -121 |
| 2008-07-08 | vs ARI | 91 | L 0-2 | 34-57 | 5 | 26,820 | Odalis Perez | Brandon Webb | Brandon Webb | Odalis Perez | Brandon Lyon | 326 | 449 | -123 |
| 2008-07-09 | vs ARI | 92 | W 5-0 | 35-57 | 5 | 25,862 | John Lannan | Micah Owings | John Lannan | Micah Owings | | 331 | 449 | -118 |
| 2008-07-10 | vs ARI | 93 | L 5-7 | 35-58 | 5 | 27,330 | Jason Bergmann | Dan Haren | Chad Qualls | Luis Ayala | | 336 | 456 | -120 |
| 2008-07-11 | vs HOU | 94 | W 10-0 | 36-58 | 5 | 33,653 | Tim Redding | Roy Oswalt | Tim Redding | Chad Paronto | Steven Shell | 346 | 456 | -110 |
| 2008-07-12 | vs HOU | 95 | L 4-6 | 36-59 | 5 | 30,682 | Collin Balester | Wandy Rodriguez | Wandy Rodriguez | Collin Balester | Jose Valverde | 350 | 462 | -112 |
| 2008-07-13 | vs HOU | 96 | L 0-5 | 36-60 | 5 | 31,463 | Odalis Perez | Brandon Backe | Brandon Backe | Odalis Perez | | 350 | 467 | -117 |
| 2008-07-18 | @ ATL | 97 | L 6-7 | 36-61 | 5 | 39,861 | Tim Redding | Tim Hudson | Tim Hudson | Tim Redding | Mike Gonzalez | 356 | 474 | -118 |
| 2008-07-19 | @ ATL | 98 | W 8-2 | 37-61 | 5 | 43,285 | John Lannan | Jair Jurrjens | John Lannan | Jair Jurrjens | | 364 | 476 | -112 |
| 2008-07-20 | @ ATL | 99 | W 15-6 | 38-61 | 5 | 29,320 | Odalis Perez | Jo-Jo Reyes | Odalis Perez | Jo-Jo Reyes | | 379 | 482 | -103 |
| 2008-07-22 | @ SFN | 100 | L 3-6 | 38-62 | 5 | 34,813 | Jason Bergmann | Barry Zito | Barry Zito | Jason Bergmann | Brian Wilson | 382 | 488 | -106 |
| 2008-07-23 | @ SFN | 101 | L 4-6 | 38-63 | 5 | 35,539 | Collin Balester | Kevin Correia | Geno Espineli | Luis Ayala | Brian Wilson | 386 | 494 | -108 |
| 2008-07-24 | @ SFN | 102 | L 0-1 | 38-64 | 5 | 36,963 | Tim Redding | Matt Cain | Matt Cain | Tim Redding | | 386 | 495 | -109 |
| 2008-07-25 | @ LAN | 103 | L 2-3 | 38-65 | 5 | 47,313 | John Lannan | Chad Billingsley | Chad Billingsley | John Lannan | Jonathan Broxton | 388 | 498 | -110 |
| 2008-07-26 | @ LAN | 104 | L 0-6 | 38-66 | 5 | 42,122 | Odalis Perez | Derek Lowe | Derek Lowe | Odalis Perez | | 388 | 504 | -116 |
| 2008-07-27 | @ LAN | 105 | L 0-2 | 38-67 | 5 | 38,660 | Jason Bergmann | Clayton Kershaw | Clayton Kershaw | Jason Bergmann | Jonathan Broxton | 388 | 506 | -118 |
| 2008-07-29 | vs PHI | 106 | L 1-2 | 38-68 | 5 | 34,039 | Collin Balester | Brett Myers | Brett Myers | Collin Balester | Brad Lidge | 389 | 508 | -119 |
| 2008-07-30 | vs PHI | 107 | L 5-8 | 38-69 | 5 | 31,798 | Tim Redding | Jamie Moyer | Jamie Moyer | Tim Redding | Brad Lidge | 394 | 516 | -122 |
| 2008-07-31 | vs PHI | 108 | L 4-8 | 38-70 | 5 | 31,658 | John Lannan | Kyle Kendrick | Kyle Kendrick | John Lannan | | 398 | 524 | -126 |
| 2008-08-01 | vs CIN | 109 | W 5-2 | 39-70 | 5 | 30,572 | Odalis Perez | Homer Bailey | Odalis Perez | Homer Bailey | | 403 | 526 | -123 |
| 2008-08-02 | vs CIN | 110 | W 10-6 | 40-70 | 5 | 30,970 | Jason Bergmann | Josh Fogg | Charlie Manning | Mike Lincoln | | 413 | 532 | -119 |
| 2008-08-03 | vs CIN | 111 | W 4-2 | 41-70 | 5 | 32,939 | Collin Balester | Johnny Cueto | Collin Balester | Johnny Cueto | Joel Hanrahan | 417 | 534 | -117 |
| 2008-08-04 | @ COL | 112 | W 9-4 | 42-70 | 5 | 33,143 | Tim Redding | Aaron Cook | Tim Redding | Aaron Cook | | 426 | 538 | -112 |
| 2008-08-05 | @ COL | 113 | L 2-8 | 42-71 | 5 | 27,483 | John Lannan | Jorge de la Rosa | Manuel Corpas | Luis Ayala | | 428 | 546 | -118 |
| 2008-08-07 | @ COL | 114 | W 6-3 | 44-71 | 5 | 0 | Jason Bergmann | Jeff Francis | Jason Bergmann | Jeff Francis | Joel Hanrahan | 434 | 549 | -115 |
| 2008-08-07 | @ COL | 115 | W 6-3 | 44-71 | 5 | 30,448 | Odalis Perez | Ubaldo Jimenez | Odalis Perez | Ubaldo Jimenez | Joel Hanrahan | 440 | 552 | -112 |
| 2008-08-08 | @ MIL | 116 | L 0-5 | 44-72 | 5 | 43,209 | Collin Balester | CC Sabathia | CC Sabathia | Collin Balester | | 440 | 557 | -117 |
| 2008-08-09 | @ MIL | 117 | L 0-6 | 44-73 | 5 | 42,974 | Tim Redding | Ben Sheets | Ben Sheets | Tim Redding | | 440 | 563 | -123 |
| 2008-08-10 | @ MIL | 118 | L 4-5 | 44-74 | 5 | 42,423 | John Lannan | Manny Parra | Guillermo Mota | Luis Ayala | | 444 | 568 | -124 |
| 2008-08-11 | @ MIL | 119 | L 1-7 | 44-75 | 5 | 42,196 | Garrett Mock | David Bush | David Bush | Garrett Mock | | 445 | 575 | -130 |
| 2008-08-12 | vs NYN | 120 | L 3-4 | 44-76 | 5 | 32,186 | Odalis Perez | Johan Santana | Johan Santana | Saul Rivera | Pedro Feliciano | 448 | 579 | -131 |
| 2008-08-13 | vs NYN | 121 | L 0-12 | 44-77 | 5 | 30,814 | Jason Bergmann | John Maine | John Maine | Jason Bergmann | Brian Stokes | 448 | 591 | -143 |
| 2008-08-14 | vs NYN | 122 | L 3-9 | 44-78 | 5 | 31,058 | Collin Balester | Oliver Perez | Oliver Perez | Collin Balester | | 451 | 600 | -149 |
| 2008-08-15 | vs COL | 123 | L 3-4 | 44-79 | 5 | 27,965 | Tim Redding | Jorge de la Rosa | Jorge de la Rosa | Tim Redding | Brian Fuentes | 454 | 604 | -150 |
| 2008-08-16 | vs COL | 124 | L 6-13 | 44-80 | 5 | 28,909 | John Lannan | Livan Hernandez | Livan Hernandez | John Lannan | | 460 | 617 | -157 |
| 2008-08-17 | vs COL | 125 | L 2-7 | 44-81 | 5 | 31,467 | Odalis Perez | Aaron Cook | Aaron Cook | Odalis Perez | | 462 | 624 | -162 |
| 2008-08-19 | @ PHI | 126 | L 4-5 | 44-82 | 5 | 44,143 | Jason Bergmann | Joe Blanton | Ryan Madson | Steven Shell | Brad Lidge | 466 | 629 | -163 |
| 2008-08-20 | @ PHI | 127 | L 0-4 | 44-83 | 5 | 45,166 | Collin Balester | Brett Myers | Brett Myers | Collin Balester | | 466 | 633 | -167 |
| 2008-08-21 | @ PHI | 128 | W 4-3 | 45-83 | 5 | 41,568 | Tim Redding | Jamie Moyer | Saul Rivera | Ryan Madson | Joel Hanrahan | 470 | 636 | -166 |
| 2008-08-22 | @ CHN | 129 | W 13-5 | 46-83 | 5 | 40,513 | John Lannan | Jason Marquis | John Lannan | Neal Cotts | | 483 | 641 | -158 |
| 2008-08-23 | @ CHN | 130 | L 2-9 | 46-84 | 5 | 40,708 | Odalis Perez | Ryan Dempster | Ryan Dempster | Odalis Perez | | 485 | 650 | -165 |
| 2008-08-24 | @ CHN | 131 | L 1-6 | 46-85 | 5 | 40,682 | Jason Bergmann | Rich Harden | Rich Harden | Jason Bergmann | | 486 | 656 | -170 |
| 2008-08-26 | vs LAN | 132 | W 2-1 | 47-85 | 5 | 26,110 | Collin Balester | Derek Lowe | Collin Balester | Derek Lowe | Joel Hanrahan | 488 | 657 | -169 |
| 2008-08-27 | vs LAN | 133 | W 5-4 | 48-85 | 5 | 22,907 | Tim Redding | Greg Maddux | Tim Redding | Greg Maddux | Joel Hanrahan | 493 | 661 | -168 |
| 2008-08-28 | vs LAN | 134 | W 11-2 | 49-85 | 5 | 26,338 | John Lannan | Clayton Kershaw | John Lannan | Clayton Kershaw | | 504 | 663 | -159 |
| 2008-08-29 | vs ATL | 135 | W 7-3 | 50-85 | 5 | 22,737 | Odalis Perez | Jorge Campillo | Odalis Perez | Jorge Campillo | Joel Hanrahan | 511 | 666 | -155 |
| 2008-08-30 | vs ATL | 136 | W 9-8 | 51-85 | 5 | 30,326 | Jason Bergmann | Jo-Jo Reyes | Steven Shell | Vladimir Nunez | | 520 | 674 | -154 |
| 2008-08-31 | vs ATL | 137 | W 8-4 | 52-85 | 5 | 31,090 | Collin Balester | Jair Jurrjens | Garrett Mock | Elmer Dessens | | 528 | 678 | -150 |
| 2008-09-01 | vs PHI | 138 | W 7-4 | 53-85 | 5 | 28,393 | Tim Redding | Kyle Kendrick | Tim Redding | Kyle Kendrick | | 535 | 682 | -147 |
| 2008-09-02 | vs PHI | 139 | L 0-4 | 53-86 | 5 | 23,150 | John Lannan | Cole Hamels | Cole Hamels | John Lannan | | 535 | 686 | -151 |
| 2008-09-03 | vs PHI | 140 | W 9-7 | 54-86 | 5 | 23,122 | Odalis Perez | Joe Blanton | Saul Rivera | Chad Durbin | | 544 | 693 | -149 |
| 2008-09-04 | @ ATL | 141 | L 0-2 | 54-87 | 5 | 18,708 | Shairon Martis | James Parr | James Parr | Shairon Martis | Mike Gonzalez | 544 | 695 | -151 |
| 2008-09-05 | @ ATL | 142 | L 5-10 | 54-88 | 5 | 25,064 | Jason Bergmann | Jair Jurrjens | Jair Jurrjens | Jason Bergmann | | 549 | 705 | -156 |
| 2008-09-06 | @ ATL | 143 | W 8-5 | 55-88 | 5 | 34,369 | Tim Redding | Mike Hampton | Joel Hanrahan | Mike Gonzalez | Steven Shell | 557 | 710 | -153 |
| 2008-09-07 | @ ATL | 144 | W 7-4 | 56-88 | 5 | 30,753 | Collin Balester | Jo-Jo Reyes | Steven Shell | Jeff Bennett | Joel Hanrahan | 564 | 714 | -150 |
| 2008-09-09 | @ NYN | 145 | L 8-10 | 56-89 | 5 | 50,382 | John Lannan | Oliver Perez | Joe Smith | Charlie Manning | Luis Ayala | 572 | 724 | -152 |
| 2008-09-10 | @ NYN | 146 | L 10-13 | 56-90 | 5 | 52,431 | Odalis Perez | Mike Pelfrey | Joe Smith | Saul Rivera | Luis Ayala | 582 | 737 | -155 |
| 2008-09-12 | @ FLO | 147 | L 1-2 | 56-91 | 5 | 12,121 | Shairon Martis | Scott Olsen | Scott Olsen | Shairon Martis | Matt Lindstrom | 583 | 739 | -156 |
| 2008-09-13 | @ FLO | 148 | L 2-4 | 56-92 | 5 | 16,307 | Tim Redding | Josh Johnson | Josh Johnson | Tim Redding | Matt Lindstrom | 585 | 743 | -158 |
| 2008-09-14 | @ FLO | 149 | L 7-8 | 56-93 | 5 | 12,024 | Collin Balester | Anibal Sanchez | Andrew Miller | Steven Shell | Arthur Rhodes | 592 | 751 | -159 |
| 2008-09-15 | vs NYN | 150 | W 7-2 | 57-93 | 5 | 21,759 | John Lannan | Pedro Martinez | John Lannan | Pedro Martinez | | 599 | 753 | -154 |
| 2008-09-16 | vs NYN | 151 | W 1-0 | 58-93 | 5 | 24,997 | Odalis Perez | Mike Pelfrey | Odalis Perez | Mike Pelfrey | Joel Hanrahan | 600 | 753 | -153 |
| 2008-09-17 | vs NYN | 152 | L 7-9 | 58-94 | 5 | 25,019 | Shairon Martis | Brandon Knight | Brandon Knight | Shairon Martis | Luis Ayala | 607 | 762 | -155 |
| 2008-09-18 | vs NYN | 153 | L 2-7 | 58-95 | 5 | 25,426 | Tim Redding | Johan Santana | Johan Santana | Tim Redding | | 609 | 769 | -160 |
| 2008-09-19 | vs SDN | 154 | L 6-11 | 58-96 | 5 | 28,600 | Collin Balester | Dirk Hayhurst | Justin Hampson | Levale Speigner | | 615 | 780 | -165 |
| 2008-09-20 | vs SDN | 155 | L 1-6 | 58-97 | 5 | 27,474 | John Lannan | Chris Young | Chris Young | John Lannan | | 616 | 786 | -170 |
| 2008-09-21 | vs SDN | 156 | L 2-6 | 58-98 | 5 | 29,608 | Odalis Perez | Cha-Seung Baek | Cha-Seung Baek | Odalis Perez | | 618 | 792 | -174 |
| 2008-09-23 | vs FLO | 157 | W 9-4 | 59-98 | 5 | 20,657 | Shairon Martis | Scott Olsen | Shairon Martis | Scott Olsen | | 627 | 796 | -169 |
| 2008-09-24 | vs FLO | 158 | L 4-9 | 59-99 | 5 | 23,299 | Tim Redding | Josh Johnson | Josh Johnson | Tim Redding | | 631 | 805 | -174 |
| 2008-09-26 | @ PHI | 159 | L 4-8 | 59-100 | 5 | 44,145 | Collin Balester | Joe Blanton | Joe Blanton | Collin Balester | | 635 | 813 | -178 |
| 2008-09-27 | @ PHI | 160 | L 3-4 | 59-101 | 5 | 45,177 | John Lannan | Jamie Moyer | Jamie Moyer | John Lannan | Brad Lidge | 638 | 817 | -179 |
| 2008-09-28 | @ PHI | 161 | L 3-8 | 59-102 | 5 | 44,945 | Odalis Perez | Kyle Kendrick | Les Walrond | Odalis Perez | | 641 | 825 | -184 |