| West | W | L | Pct | GB |
| LA Angels | 100 | 62 | .617 | -- |
| Texas | 79 | 83 | .488 | 21.0 |
| Oakland | 75 | 86 | .466 | 24.5 |
| Seattle | 61 | 101 | .377 | 39.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2008-03-31 | Erik Bedard | L | 29 | L 5-2 | vs TEX | 1 | 112 | - | 5.0 | 3 | 1 | 1 | 1 | 4 | 5 | 105 | 47 | 58 | 55% | 0-0 | 1.80 | 1.40 |
| 2008-04-01 | Felix Hernandez | R | 22 | W 4-5 | vs TEX | 1 | 74 | - | 7.0 | 5 | 1 | 0 | 0 | 3 | 3 | 96 | 37 | 59 | 61% | 0-0 | 0.00 | 1.14 |
| 2008-04-02 | Carlos Silva | R | 29 | L 4-1 | vs TEX | 1 | 126 | W | 7.0 | 3 | 1 | 1 | 1 | 3 | 5 | 116 | 48 | 68 | 59% | 1-0 | 1.29 | 0.86 |
| 2008-04-04 | Jarrod Washburn | L | 34 | L 4-7 | @ BAL | 1 | 247 | L | 5.0 | 6 | 3 | 3 | 1 | 1 | 4 | 100 | 38 | 62 | 62% | 0-1 | 5.40 | 1.40 |
| 2008-04-05 | Miguel Batista | R | 37 | L 4-6 | @ BAL | 1 | 218 | L | 5.0 | 7 | 5 | 4 | 0 | 4 | 3 | 109 | 52 | 57 | 52% | 0-1 | 6.00 | 1.83 |
| 2008-04-06 | Felix Hernandez | R | 22 | L 2-3 | @ BAL | 2 | 75 | - | 8.0 | 5 | 0 | 0 | 0 | 2 | 6 | 97 | 35 | 62 | 64% | 0-0 | 0.00 | 1.00 |
| 2008-04-07 | Carlos Silva | R | 29 | L 4-5 | @ BAL | 2 | 127 | - | 7.0 | 9 | 4 | 4 | 1 | 0 | 5 | 99 | 34 | 65 | 66% | 1-0 | 3.21 | 1.07 |
| 2008-04-08 | Erik Bedard | L | 29 | W 6-5 | @ TBA | 2 | 113 | W | 6.0 | 5 | 5 | 3 | 2 | 4 | 5 | 110 | 41 | 69 | 63% | 1-0 | 3.27 | 1.45 |
| 2008-04-09 | Jarrod Washburn | L | 34 | W 7-1 | @ TBA | 2 | 248 | W | 7.0 | 6 | 1 | 1 | 0 | 1 | 2 | 105 | 40 | 65 | 62% | 1-1 | 3.00 | 1.17 |
| 2008-04-10 | Miguel Batista | R | 37 | L 0-7 | @ TBA | 2 | 219 | L | 6.0 | 8 | 4 | 4 | 1 | 3 | 4 | 111 | 46 | 65 | 59% | 0-2 | 6.00 | 1.83 |
| 2008-04-11 | Felix Hernandez | R | 22 | L 8-5 | vs ANA | 3 | 76 | W | 6.2 | 9 | 4 | 4 | 2 | 3 | 7 | 116 | 49 | 67 | 58% | 1-0 | 1.64 | 1.23 |
| 2008-04-12 | Carlos Silva | R | 29 | L 8-3 | vs ANA | 3 | 128 | W | 8.0 | 11 | 3 | 3 | 1 | 1 | 0 | 98 | 32 | 66 | 67% | 2-0 | 3.27 | 1.23 |
| 2008-04-13 | Cha-Seung Baek | R | 28 | W 5-10 | vs ANA | 1 | 24 | L | 4.1 | 7 | 4 | 4 | 0 | 2 | 2 | 84 | 33 | 51 | 61% | 0-1 | 12.60 | 2.40 |
| 2008-04-14 | Jarrod Washburn | L | 34 | W 1-5 | vs KCA | 3 | 249 | L | 6.0 | 6 | 3 | 3 | 2 | 0 | 6 | 97 | 33 | 64 | 66% | 1-2 | 3.50 | 1.11 |
| 2008-04-15 | Miguel Batista | R | 37 | L 11-6 | vs KCA | 3 | 220 | W | 5.0 | 7 | 4 | 4 | 0 | 2 | 1 | 83 | 33 | 50 | 60% | 1-2 | 6.35 | 1.82 |
| 2008-04-16 | Felix Hernandez | R | 22 | W 4-2 | @ OAK | 4 | 77 | W | 9.0 | 8 | 2 | 1 | 0 | 1 | 8 | 113 | 35 | 78 | 69% | 2-0 | 1.45 | 1.16 |
| 2008-04-17 | Carlos Silva | R | 29 | W 8-1 | @ OAK | 4 | 129 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 1 | 98 | 33 | 65 | 66% | 3-0 | 2.79 | 1.14 |
| 2008-04-18 | R.A. Dickey | R | 33 | L 4-5 | @ ANA | 1 | 34 | L | 6.0 | 8 | 5 | 5 | 0 | 2 | 2 | 99 | 39 | 60 | 61% | 0-1 | 6.43 | 1.43 |
| 2008-04-19 | Jarrod Washburn | L | 34 | L 1-4 | @ ANA | 4 | 250 | L | 6.0 | 10 | 4 | 4 | 0 | 0 | 1 | 100 | 36 | 64 | 64% | 1-3 | 4.13 | 1.25 |
| 2008-04-20 | Miguel Batista | R | 37 | W 4-2 | @ ANA | 4 | 221 | W | 7.2 | 8 | 0 | 0 | 0 | 1 | 8 | 114 | 42 | 72 | 63% | 2-2 | 4.32 | 1.60 |
| 2008-04-22 | Felix Hernandez | R | 22 | L 4-2 | vs BAL | 5 | 78 | - | 7.0 | 6 | 2 | 2 | 1 | 3 | 7 | 109 | 36 | 73 | 67% | 2-0 | 1.66 | 1.18 |
| 2008-04-23 | Carlos Silva | R | 29 | W 2-3 | vs BAL | 5 | 130 | - | 6.0 | 6 | 2 | 2 | 0 | 2 | 4 | 82 | 33 | 49 | 60% | 3-0 | 2.83 | 1.17 |
| 2008-04-24 | Jarrod Washburn | L | 34 | W 7-8 | vs BAL | 5 | 251 | - | 5.0 | 6 | 2 | 2 | 1 | 3 | 2 | 97 | 44 | 53 | 55% | 1-3 | 4.03 | 1.34 |
| 2008-04-25 | Miguel Batista | R | 37 | W 3-4 | vs OAK | 5 | 222 | L | 1.0 | 2 | 3 | 3 | 0 | 5 | 2 | 47 | 26 | 21 | 45% | 2-3 | 5.19 | 1.81 |
| 2008-04-26 | Erik Bedard | L | 29 | L 5-3 | vs OAK | 3 | 114 | W | 6.2 | 2 | 0 | 0 | 0 | 4 | 4 | 95 | 33 | 62 | 65% | 2-0 | 2.00 | 1.22 |
| 2008-04-27 | Felix Hernandez | R | 22 | W 2-4 | vs OAK | 6 | 79 | L | 7.0 | 6 | 4 | 4 | 0 | 4 | 10 | 115 | 40 | 75 | 65% | 2-1 | 2.20 | 1.22 |
| 2008-04-29 | Carlos Silva | R | 29 | W 7-2 | @ CLE | 6 | 131 | - | 7.0 | 7 | 2 | 2 | 0 | 1 | 3 | 101 | 36 | 65 | 64% | 3-0 | 2.79 | 1.17 |
| 2008-04-30 | Jarrod Washburn | L | 34 | L 3-8 | @ CLE | 6 | 252 | L | 4.1 | 6 | 6 | 5 | 1 | 2 | 7 | 100 | 41 | 59 | 59% | 1-4 | 4.91 | 1.42 |
| 2008-05-01 | Miguel Batista | R | 37 | L 2-3 | @ CLE | 6 | 223 | - | 7.0 | 4 | 1 | 1 | 0 | 3 | 6 | 101 | 41 | 60 | 59% | 2-3 | 4.36 | 1.64 |
| 2008-05-02 | Erik Bedard | L | 29 | L 1-5 | @ NYA | 4 | 115 | L | 7.0 | 4 | 3 | 1 | 0 | 1 | 6 | 105 | 31 | 74 | 70% | 2-1 | 1.80 | 1.08 |
| 2008-05-03 | Felix Hernandez | R | 22 | L 1-6 | @ NYA | 7 | 80 | L | 5.2 | 12 | 6 | 6 | 1 | 3 | 3 | 107 | 46 | 61 | 57% | 2-2 | 3.06 | 1.40 |
| 2008-05-04 | Carlos Silva | R | 29 | L 2-8 | @ NYA | 7 | 132 | L | 3.0 | 11 | 8 | 8 | 2 | 0 | 1 | 81 | 26 | 55 | 68% | 3-1 | 4.20 | 1.33 |
| 2008-05-05 | Jarrod Washburn | L | 34 | L 7-3 | vs TEX | 7 | 253 | W | 6.0 | 4 | 3 | 3 | 0 | 0 | 3 | 85 | 30 | 55 | 65% | 2-4 | 4.85 | 1.31 |
| 2008-05-06 | Miguel Batista | R | 37 | W 1-10 | vs TEX | 7 | 224 | L | 2.1 | 3 | 6 | 6 | 1 | 6 | 2 | 84 | 40 | 44 | 52% | 2-4 | 5.66 | 1.80 |
| 2008-05-07 | Erik Bedard | L | 29 | W 0-2 | vs TEX | 5 | 116 | L | 7.0 | 6 | 2 | 2 | 1 | 1 | 5 | 108 | 37 | 71 | 66% | 2-2 | 1.97 | 1.06 |
| 2008-05-08 | Felix Hernandez | R | 22 | W 0-5 | vs TEX | 8 | 81 | L | 5.0 | 6 | 4 | 4 | 1 | 3 | 5 | 112 | 42 | 70 | 63% | 2-3 | 3.44 | 1.44 |
| 2008-05-09 | Carlos Silva | R | 29 | W 2-4 | vs CHA | 8 | 133 | L | 7.0 | 8 | 4 | 4 | 1 | 2 | 1 | 108 | 43 | 65 | 60% | 3-2 | 4.33 | 1.35 |
| 2008-05-10 | Jarrod Washburn | L | 34 | W 4-8 | vs CHA | 8 | 254 | L | 5.0 | 8 | 7 | 7 | 2 | 2 | 3 | 103 | 39 | 64 | 62% | 2-5 | 5.73 | 1.39 |
| 2008-05-11 | Miguel Batista | R | 37 | L 6-3 | vs CHA | 8 | 225 | W | 5.1 | 10 | 3 | 3 | 0 | 3 | 6 | 112 | 42 | 70 | 63% | 3-4 | 5.63 | 1.90 |
| 2008-05-12 | Erik Bedard | L | 29 | L 12-13 | @ TEX | 6 | 117 | - | 2.0 | 7 | 6 | 6 | 2 | 4 | 2 | 63 | 33 | 30 | 48% | 2-2 | 3.44 | 1.32 |
| 2008-05-13 | Felix Hernandez | R | 22 | L 2-5 | @ TEX | 9 | 82 | L | 6.0 | 6 | 3 | 2 | 0 | 5 | 3 | 116 | 51 | 65 | 56% | 2-4 | 3.39 | 1.48 |
| 2008-05-14 | Carlos Silva | R | 29 | W 4-3 | @ TEX | 9 | 134 | - | 6.1 | 5 | 2 | 2 | 0 | 0 | 4 | 88 | 29 | 59 | 67% | 3-2 | 4.19 | 1.29 |
| 2008-05-16 | Miguel Batista | R | 37 | W 4-6 | vs SDN | 9 | 226 | L | 5.1 | 9 | 6 | 6 | 1 | 3 | 1 | 105 | 44 | 61 | 58% | 3-5 | 6.07 | 1.91 |
| 2008-05-17 | Erik Bedard | L | 29 | L 4-2 | vs SDN | 7 | 118 | W | 8.0 | 5 | 2 | 2 | 1 | 1 | 10 | 101 | 33 | 68 | 67% | 3-2 | 3.21 | 1.21 |
| 2008-05-18 | Felix Hernandez | R | 22 | L 3-2 | vs SDN | 10 | 83 | - | 6.0 | 7 | 2 | 2 | 1 | 1 | 5 | 91 | 31 | 60 | 66% | 2-4 | 3.36 | 1.46 |
| 2008-05-20 | Carlos Silva | R | 29 | L 8-12 | @ DET | 10 | 135 | L | 4.0 | 9 | 7 | 7 | 0 | 1 | 0 | 72 | 23 | 49 | 68% | 3-3 | 4.94 | 1.37 |
| 2008-05-21 | Jarrod Washburn | L | 34 | L 4-9 | @ DET | 9 | 255 | L | 2.1 | 12 | 9 | 9 | 1 | 0 | 2 | 60 | 17 | 43 | 72% | 2-6 | 6.94 | 1.54 |
| 2008-05-22 | Miguel Batista | R | 37 | L 2-9 | @ DET | 10 | 227 | L | 3.0 | 7 | 5 | 4 | 1 | 1 | 2 | 72 | 30 | 42 | 58% | 3-6 | 6.43 | 1.96 |
| 2008-05-23 | Erik Bedard | L | 29 | L 2-13 | @ NYA | 8 | 119 | L | 4.1 | 8 | 9 | 9 | 1 | 1 | 3 | 73 | 26 | 47 | 64% | 3-3 | 4.70 | 1.30 |
| 2008-05-24 | Carlos Silva | R | 29 | L 6-12 | @ NYA | 11 | 136 | L | 6.0 | 11 | 7 | 5 | 2 | 1 | 2 | 106 | 38 | 68 | 64% | 3-4 | 5.16 | 1.43 |
| 2008-05-25 | Jarrod Washburn | L | 34 | L 5-6 | @ NYA | 10 | 256 | - | 6.0 | 4 | 2 | 2 | 0 | 3 | 2 | 98 | 45 | 53 | 54% | 2-6 | 6.50 | 1.50 |
| 2008-05-26 | Felix Hernandez | R | 22 | W 3-5 | vs BOS | 11 | 84 | L | 7.2 | 7 | 5 | 5 | 1 | 5 | 5 | 110 | 45 | 65 | 59% | 2-5 | 3.60 | 1.47 |
| 2008-05-27 | Miguel Batista | R | 37 | L 4-3 | vs BOS | 11 | 228 | - | 7.0 | 5 | 3 | 2 | 1 | 3 | 2 | 102 | 43 | 59 | 58% | 3-6 | 5.95 | 1.86 |
| 2008-05-28 | Erik Bedard | L | 29 | L 1-0 | vs BOS | 9 | 120 | W | 7.0 | 2 | 0 | 0 | 0 | 3 | 8 | 110 | 40 | 70 | 64% | 4-3 | 4.08 | 1.23 |
| 2008-05-30 | Carlos Silva | R | 29 | W 4-7 | vs DET | 12 | 137 | L | 0.2 | 7 | 7 | 7 | 0 | 0 | 0 | 34 | 12 | 22 | 65% | 3-5 | 6.00 | 1.51 |
| 2008-05-31 | Felix Hernandez | R | 22 | L 5-0 | vs DET | 12 | 85 | W | 7.0 | 2 | 0 | 0 | 0 | 0 | 7 | 86 | 28 | 58 | 67% | 3-5 | 3.29 | 1.37 |
| 2008-06-01 | Miguel Batista | R | 37 | W 5-7 | vs DET | 12 | 229 | - | 5.1 | 5 | 3 | 3 | 0 | 4 | 2 | 96 | 37 | 59 | 61% | 3-6 | 5.90 | 1.85 |
| 2008-06-02 | Jarrod Washburn | L | 34 | W 2-4 | vs ANA | 11 | 257 | L | 5.1 | 9 | 4 | 4 | 1 | 3 | 4 | 91 | 34 | 57 | 63% | 2-7 | 6.56 | 1.58 |
| 2008-06-03 | Erik Bedard | L | 29 | W 4-5 | vs ANA | 10 | 121 | L | 3.1 | 7 | 5 | 4 | 0 | 3 | 1 | 75 | 26 | 49 | 65% | 4-4 | 4.50 | 1.34 |
| 2008-06-04 | Carlos Silva | R | 29 | W 4-5 | vs ANA | 13 | 138 | L | 8.0 | 8 | 5 | 5 | 0 | 2 | 2 | 111 | 35 | 76 | 68% | 3-6 | 5.96 | 1.48 |
| 2008-06-06 | Felix Hernandez | R | 22 | W 8-0 | @ BOS | 13 | 86 | W | 6.0 | 6 | 0 | 0 | 0 | 3 | 5 | 105 | 39 | 66 | 63% | 4-5 | 3.07 | 1.38 |
| 2008-06-07 | Miguel Batista | R | 37 | L 3-11 | @ BOS | 13 | 230 | L | 4.1 | 6 | 5 | 4 | 1 | 6 | 1 | 89 | 47 | 42 | 47% | 3-7 | 6.09 | 1.92 |
| 2008-06-08 | Erik Bedard | L | 29 | L 1-2 | @ BOS | 11 | 122 | - | 5.0 | 2 | 1 | 1 | 0 | 3 | 5 | 99 | 36 | 63 | 64% | 4-4 | 4.28 | 1.31 |
| 2008-06-09 | Jarrod Washburn | L | 34 | W 3-2 | @ TOR | 12 | 258 | - | 6.0 | 5 | 1 | 1 | 0 | 3 | 4 | 103 | 45 | 58 | 56% | 2-7 | 6.09 | 1.55 |
| 2008-06-10 | Carlos Silva | R | 29 | L 1-3 | @ TOR | 14 | 139 | L | 7.0 | 9 | 3 | 3 | 2 | 0 | 3 | 97 | 31 | 66 | 68% | 3-7 | 5.79 | 1.46 |
| 2008-06-11 | Felix Hernandez | R | 22 | W 2-1 | @ TOR | 14 | 87 | W | 8.0 | 4 | 1 | 0 | 0 | 1 | 8 | 97 | 30 | 67 | 69% | 5-5 | 2.81 | 1.31 |
| 2008-06-13 | R.A. Dickey | R | 34 | W 6-7 | vs WAS | 2 | 35 | L | 1.2 | 8 | 7 | 7 | 0 | 2 | 1 | 51 | 19 | 32 | 63% | 1-2 | 4.66 | 1.38 |
| 2008-06-14 | Erik Bedard | L | 29 | W 2-5 | vs WAS | 12 | 123 | - | 6.0 | 9 | 2 | 2 | 0 | 2 | 8 | 99 | 36 | 63 | 64% | 4-4 | 4.16 | 1.36 |
| 2008-06-15 | Jarrod Washburn | L | 34 | W 2-6 | vs WAS | 13 | 259 | - | 6.0 | 8 | 2 | 2 | 0 | 4 | 2 | 105 | 46 | 59 | 56% | 2-7 | 5.83 | 1.59 |
| 2008-06-16 | Carlos Silva | R | 29 | W 1-6 | vs FLO | 15 | 140 | L | 4.2 | 5 | 3 | 3 | 0 | 1 | 4 | 70 | 27 | 43 | 61% | 3-8 | 5.76 | 1.45 |
| 2008-06-17 | Felix Hernandez | R | 22 | L 5-4 | vs FLO | 15 | 88 | W | 7.1 | 6 | 4 | 3 | 1 | 1 | 9 | 105 | 31 | 74 | 70% | 6-5 | 2.88 | 1.29 |
| 2008-06-18 | R.A. Dickey | R | 34 | W 3-8 | vs FLO | 3 | 36 | L | 3.2 | 6 | 5 | 5 | 1 | 4 | 4 | 97 | 41 | 56 | 58% | 1-3 | 5.63 | 1.56 |
| 2008-06-20 | Erik Bedard | L | 29 | W 10-2 | @ ATL | 13 | 124 | - | 3.0 | 2 | 0 | 0 | 0 | 0 | 1 | 36 | 13 | 23 | 64% | 4-4 | 3.99 | 1.33 |
| 2008-06-21 | Jarrod Washburn | L | 34 | L 4-5 | @ ATL | 14 | 260 | - | 5.2 | 6 | 1 | 1 | 0 | 3 | 8 | 119 | 45 | 74 | 62% | 2-7 | 5.49 | 1.58 |
| 2008-06-22 | Carlos Silva | R | 29 | L 3-8 | @ ATL | 16 | 141 | L | 4.0 | 9 | 4 | 4 | 3 | 0 | 1 | 59 | 18 | 41 | 69% | 3-9 | 5.90 | 1.48 |
| 2008-06-23 | Felix Hernandez | R | 22 | W 5-2 | @ NYN | 16 | 89 | - | 4.2 | 2 | 1 | 1 | 0 | 0 | 2 | 51 | 18 | 33 | 65% | 6-5 | 2.83 | 1.25 |
| 2008-06-24 | R.A. Dickey | R | 34 | W 11-0 | @ NYN | 4 | 37 | W | 7.0 | 6 | 0 | 0 | 0 | 2 | 5 | 115 | 37 | 78 | 68% | 2-3 | 4.83 | 1.49 |
| 2008-06-25 | Miguel Batista | R | 37 | L 2-8 | @ NYN | 14 | 231 | L | 2.2 | 5 | 8 | 4 | 3 | 5 | 3 | 85 | 40 | 45 | 53% | 3-10 | 6.50 | 1.96 |
| 2008-06-27 | Jarrod Washburn | L | 34 | W 5-2 | @ SDN | 15 | 261 | W | 7.2 | 7 | 2 | 2 | 1 | 1 | 2 | 119 | 43 | 76 | 64% | 3-7 | 5.25 | 1.55 |
| 2008-06-28 | Carlos Silva | R | 29 | W 4-2 | @ SDN | 17 | 142 | W | 7.0 | 8 | 2 | 2 | 0 | 0 | 3 | 87 | 25 | 62 | 71% | 4-9 | 5.67 | 1.46 |
| 2008-06-29 | Erik Bedard | L | 29 | W 9-2 | @ SDN | 14 | 125 | W | 5.2 | 3 | 1 | 1 | 0 | 3 | 3 | 94 | 43 | 51 | 54% | 5-4 | 3.79 | 1.30 |
| 2008-06-30 | R.A. Dickey | R | 34 | W 0-2 | vs TOR | 5 | 38 | L | 6.1 | 9 | 2 | 2 | 0 | 1 | 3 | 116 | 45 | 71 | 61% | 2-4 | 4.50 | 1.48 |
| 2008-07-01 | Ryan Rowland-Smith | L | 25 | L 7-6 | vs TOR | 1 | 1 | - | 3.2 | 4 | 3 | 3 | 0 | 1 | 1 | 61 | 16 | 45 | 74% | 2-1 | 3.07 | 1.18 |
| 2008-07-02 | Jarrod Washburn | L | 34 | L 4-2 | vs TOR | 16 | 262 | W | 6.0 | 7 | 2 | 2 | 1 | 2 | 4 | 97 | 37 | 60 | 62% | 4-7 | 5.10 | 1.54 |
| 2008-07-03 | Carlos Silva | R | 29 | W 4-8 | vs DET | 18 | 143 | L | 5.0 | 9 | 5 | 5 | 0 | 2 | 3 | 99 | 41 | 58 | 59% | 4-10 | 5.83 | 1.50 |
| 2008-07-04 | Erik Bedard | L | 29 | L 4-1 | vs DET | 15 | 126 | W | 5.0 | 5 | 1 | 1 | 1 | 3 | 6 | 98 | 41 | 57 | 58% | 6-4 | 3.67 | 1.32 |
| 2008-07-05 | R.A. Dickey | R | 34 | L 3-2 | vs DET | 6 | 39 | - | 6.0 | 4 | 2 | 2 | 2 | 5 | 3 | 104 | 46 | 58 | 56% | 2-4 | 4.33 | 1.48 |
| 2008-07-06 | Ryan Rowland-Smith | L | 25 | W 1-2 | vs DET | 2 | 2 | - | 5.0 | 5 | 1 | 1 | 1 | 3 | 2 | 82 | 29 | 53 | 65% | 2-1 | 2.94 | 1.22 |
| 2008-07-07 | Jarrod Washburn | L | 34 | L 3-4 | @ OAK | 17 | 263 | L | 8.0 | 7 | 4 | 4 | 1 | 0 | 5 | 102 | 36 | 66 | 65% | 4-8 | 5.05 | 1.49 |
| 2008-07-08 | Carlos Silva | R | 29 | L 0-2 | @ OAK | 19 | 144 | L | 8.0 | 7 | 2 | 2 | 0 | 0 | 5 | 93 | 32 | 61 | 66% | 4-11 | 5.58 | 1.45 |
| 2008-07-09 | Miguel Batista | R | 37 | W 6-4 | @ OAK | 15 | 232 | - | 2.0 | 1 | 1 | 1 | 1 | 0 | 1 | 20 | 5 | 15 | 75% | 4-10 | 6.19 | 1.88 |
| 2008-07-10 | R.A. Dickey | R | 34 | L 2-3 | @ OAK | 7 | 40 | - | 7.0 | 4 | 0 | 0 | 0 | 4 | 4 | 125 | 55 | 70 | 56% | 2-4 | 3.84 | 1.44 |
| 2008-07-11 | Felix Hernandez | R | 22 | L 1-3 | @ KCA | 17 | 90 | L | 5.0 | 4 | 3 | 3 | 0 | 1 | 8 | 90 | 31 | 59 | 66% | 6-6 | 2.95 | 1.24 |
| 2008-07-12 | Jarrod Washburn | L | 34 | L 4-5 | @ KCA | 18 | 264 | - | 6.0 | 7 | 3 | 1 | 0 | 1 | 1 | 111 | 41 | 70 | 63% | 4-8 | 4.85 | 1.48 |
| 2008-07-13 | Carlos Silva | R | 29 | W 4-3 | @ KCA | 20 | 145 | - | 6.0 | 8 | 2 | 2 | 0 | 1 | 5 | 101 | 40 | 61 | 60% | 4-11 | 5.45 | 1.45 |
| 2008-07-18 | Felix Hernandez | R | 22 | L 8-2 | vs CLE | 18 | 91 | W | 6.0 | 4 | 2 | 2 | 1 | 2 | 8 | 95 | 35 | 60 | 63% | 7-6 | 2.95 | 1.23 |
| 2008-07-19 | Miguel Batista | R | 37 | W 6-9 | vs CLE | 16 | 233 | L | 2.0 | 7 | 8 | 8 | 1 | 1 | 2 | 58 | 26 | 32 | 55% | 4-11 | 6.95 | 1.94 |
| 2008-07-20 | Carlos Silva | R | 29 | W 2-6 | vs CLE | 21 | 146 | L | 3.0 | 4 | 4 | 4 | 1 | 1 | 1 | 72 | 28 | 44 | 61% | 4-12 | 5.61 | 1.46 |
| 2008-07-21 | Jarrod Washburn | L | 34 | W 0-4 | vs BOS | 19 | 265 | L | 5.2 | 7 | 2 | 2 | 1 | 2 | 3 | 111 | 50 | 61 | 55% | 4-9 | 4.75 | 1.48 |
| 2008-07-22 | R.A. Dickey | R | 34 | W 2-4 | vs BOS | 8 | 41 | L | 6.0 | 9 | 4 | 4 | 1 | 3 | 0 | 105 | 37 | 68 | 65% | 2-5 | 3.91 | 1.49 |
| 2008-07-23 | Felix Hernandez | R | 22 | W 3-6 | vs BOS | 19 | 92 | - | 6.0 | 6 | 3 | 2 | 0 | 5 | 6 | 105 | 38 | 67 | 64% | 7-6 | 2.95 | 1.26 |
| 2008-07-25 | Miguel Batista | R | 37 | L 4-5 | @ TOR | 17 | 234 | - | 5.1 | 5 | 2 | 2 | 1 | 2 | 2 | 80 | 33 | 47 | 59% | 4-11 | 6.67 | 1.92 |
| 2008-07-26 | R.A. Dickey | R | 34 | L 3-8 | @ TOR | 9 | 42 | L | 5.1 | 10 | 8 | 8 | 2 | 4 | 3 | 107 | 44 | 63 | 59% | 2-6 | 4.62 | 1.58 |
| 2008-07-27 | Jarrod Washburn | L | 34 | W 5-1 | @ TOR | 20 | 266 | W | 8.0 | 4 | 1 | 1 | 1 | 2 | 2 | 100 | 33 | 67 | 67% | 5-9 | 4.50 | 1.43 |
| 2008-07-28 | Felix Hernandez | R | 22 | W 7-5 | @ TEX | 20 | 93 | - | 6.0 | 6 | 4 | 3 | 0 | 4 | 6 | 112 | 42 | 70 | 63% | 7-6 | 3.02 | 1.27 |
| 2008-07-29 | Carlos Silva | R | 29 | L 10-11 | @ TEX | 22 | 147 | - | 2.1 | 7 | 6 | 6 | 1 | 1 | 1 | 42 | 17 | 25 | 60% | 4-12 | 5.95 | 1.50 |
| 2008-07-30 | Miguel Batista | R | 37 | L 3-4 | @ TEX | 18 | 235 | - | 6.0 | 7 | 3 | 2 | 2 | 2 | 3 | 90 | 29 | 61 | 68% | 4-11 | 6.43 | 1.89 |
| 2008-07-31 | R.A. Dickey | R | 34 | W 8-5 | @ TEX | 10 | 43 | W | 7.2 | 6 | 2 | 2 | 1 | 1 | 2 | 90 | 34 | 56 | 62% | 3-6 | 4.39 | 1.51 |
| 2008-08-01 | Jarrod Washburn | L | 34 | W 5-10 | vs BAL | 21 | 267 | L | 4.2 | 9 | 6 | 6 | 0 | 4 | 2 | 96 | 40 | 56 | 58% | 5-10 | 4.76 | 1.48 |
| 2008-08-02 | Felix Hernandez | R | 22 | W 1-3 | vs BAL | 21 | 94 | L | 5.0 | 8 | 2 | 2 | 0 | 2 | 6 | 109 | 40 | 69 | 63% | 7-7 | 3.04 | 1.30 |
| 2008-08-03 | Carlos Silva | R | 29 | L 8-4 | vs BAL | 23 | 148 | - | 6.2 | 9 | 4 | 4 | 1 | 1 | 2 | 116 | 45 | 71 | 61% | 4-12 | 5.91 | 1.50 |
| 2008-08-04 | Miguel Batista | R | 37 | L 11-6 | vs MIN | 19 | 236 | - | 3.0 | 7 | 6 | 6 | 1 | 4 | 2 | 82 | 41 | 41 | 50% | 4-11 | 6.80 | 1.95 |
| 2008-08-05 | R.A. Dickey | R | 34 | L 8-7 | vs MIN | 11 | 44 | - | 7.0 | 8 | 3 | 3 | 1 | 2 | 3 | 104 | 41 | 63 | 61% | 3-6 | 4.35 | 1.51 |
| 2008-08-06 | Jarrod Washburn | L | 34 | W 3-7 | vs MIN | 22 | 268 | L | 6.0 | 5 | 4 | 3 | 0 | 3 | 6 | 99 | 42 | 57 | 58% | 5-11 | 4.74 | 1.47 |
| 2008-08-07 | Felix Hernandez | R | 22 | L 2-1 | vs TBA | 22 | 95 | - | 8.0 | 4 | 1 | 1 | 0 | 3 | 5 | 104 | 41 | 63 | 61% | 7-7 | 2.94 | 1.28 |
| 2008-08-08 | Carlos Silva | R | 29 | W 3-5 | vs TBA | 24 | 149 | L | 6.0 | 8 | 5 | 4 | 1 | 3 | 3 | 98 | 38 | 60 | 61% | 4-13 | 5.91 | 1.51 |
| 2008-08-09 | Ryan Rowland-Smith | L | 26 | W 7-8 | vs TBA | 3 | 3 | - | 5.2 | 7 | 4 | 4 | 1 | 2 | 5 | 105 | 40 | 65 | 62% | 2-1 | 3.69 | 1.38 |
| 2008-08-10 | R.A. Dickey | R | 34 | W 3-11 | vs TBA | 12 | 45 | L | 5.0 | 8 | 8 | 8 | 2 | 4 | 6 | 110 | 44 | 66 | 60% | 3-7 | 4.88 | 1.55 |
| 2008-08-12 | Jarrod Washburn | L | 34 | L 3-7 | @ ANA | 23 | 269 | L | 7.0 | 7 | 4 | 1 | 2 | 0 | 3 | 93 | 33 | 60 | 65% | 5-12 | 4.57 | 1.45 |
| 2008-08-13 | Felix Hernandez | R | 22 | W 10-7 | @ ANA | 23 | 96 | - | 7.0 | 8 | 4 | 4 | 1 | 3 | 8 | 107 | 44 | 63 | 59% | 7-7 | 3.04 | 1.29 |
| 2008-08-15 | Carlos Silva | R | 29 | L 3-9 | @ MIN | 25 | 150 | L | 3.1 | 9 | 9 | 9 | 1 | 1 | 0 | 76 | 32 | 44 | 58% | 4-14 | 6.36 | 1.55 |
| 2008-08-16 | Ryan Rowland-Smith | L | 26 | L 6-7 | @ MIN | 4 | 4 | - | 5.0 | 10 | 5 | 5 | 1 | 2 | 1 | 90 | 37 | 53 | 59% | 2-1 | 4.09 | 1.45 |
| 2008-08-17 | Ryan Feierabend | L | 23 | L 8-11 | @ MIN | 1 | 12 | L | 3.0 | 10 | 6 | 6 | 0 | 1 | 1 | 54 | 16 | 38 | 70% | 0-1 | 18.00 | 3.67 |
| 2008-08-18 | Jarrod Washburn | L | 34 | L 5-13 | @ CHA | 24 | 270 | L | 4.1 | 7 | 8 | 8 | 2 | 2 | 0 | 81 | 37 | 44 | 54% | 5-13 | 4.95 | 1.47 |
| 2008-08-19 | Felix Hernandez | R | 22 | L 0-5 | @ CHA | 24 | 97 | L | 5.0 | 11 | 5 | 5 | 2 | 3 | 0 | 101 | 41 | 60 | 59% | 7-8 | 3.23 | 1.34 |
| 2008-08-20 | R.A. Dickey | R | 34 | L 3-15 | @ CHA | 13 | 46 | L | 2.0 | 6 | 8 | 8 | 2 | 2 | 0 | 57 | 23 | 34 | 60% | 3-8 | 5.55 | 1.64 |
| 2008-08-21 | Ryan Rowland-Smith | L | 26 | W 0-2 | vs OAK | 5 | 5 | L | 7.0 | 4 | 1 | 1 | 1 | 3 | 6 | 114 | 40 | 74 | 65% | 2-2 | 3.82 | 1.41 |
| 2008-08-22 | Ryan Feierabend | L | 23 | L 7-5 | vs OAK | 2 | 13 | - | 5.0 | 5 | 1 | 1 | 1 | 0 | 5 | 92 | 37 | 55 | 60% | 0-1 | 7.88 | 2.00 |
| 2008-08-23 | Jarrod Washburn | L | 34 | W 1-5 | vs OAK | 25 | 271 | L | 6.0 | 7 | 3 | 3 | 1 | 2 | 1 | 104 | 43 | 61 | 59% | 5-14 | 4.93 | 1.47 |
| 2008-08-24 | Felix Hernandez | R | 22 | L 8-4 | vs OAK | 25 | 98 | W | 6.0 | 4 | 3 | 3 | 3 | 2 | 7 | 105 | 39 | 66 | 63% | 8-8 | 3.28 | 1.33 |
| 2008-08-25 | Miguel Batista | R | 38 | L 4-2 | vs MIN | 20 | 237 | - | 6.0 | 5 | 1 | 1 | 0 | 3 | 3 | 95 | 39 | 56 | 59% | 4-12 | 6.28 | 1.89 |
| 2008-08-26 | Ryan Rowland-Smith | L | 26 | L 3-2 | vs MIN | 6 | 6 | W | 7.0 | 5 | 2 | 2 | 1 | 2 | 5 | 107 | 35 | 72 | 67% | 3-2 | 3.71 | 1.38 |
| 2008-08-27 | Ryan Feierabend | L | 23 | W 5-6 | vs MIN | 3 | 14 | - | 7.0 | 8 | 3 | 3 | 0 | 2 | 4 | 114 | 38 | 76 | 67% | 0-1 | 6.00 | 1.73 |
| 2008-08-29 | Felix Hernandez | R | 22 | W 3-2 | @ CLE | 26 | 99 | W | 6.0 | 6 | 2 | 2 | 0 | 4 | 7 | 119 | 51 | 68 | 57% | 9-8 | 3.27 | 1.34 |
| 2008-08-30 | Jarrod Washburn | L | 34 | W 4-3 | @ CLE | 26 | 272 | - | 6.2 | 3 | 0 | 0 | 0 | 4 | 8 | 106 | 46 | 60 | 57% | 5-14 | 4.71 | 1.45 |
| 2008-08-31 | Ryan Rowland-Smith | L | 26 | W 6-4 | @ CLE | 7 | 7 | W | 6.1 | 7 | 2 | 1 | 1 | 1 | 2 | 114 | 45 | 69 | 61% | 4-2 | 3.56 | 1.37 |
| 2008-09-01 | Carlos Silva | R | 29 | W 12-6 | @ TEX | 26 | 151 | - | 4.2 | 10 | 6 | 6 | 2 | 4 | 2 | 99 | 40 | 59 | 60% | 4-14 | 6.52 | 1.59 |
| 2008-09-02 | Ryan Feierabend | L | 23 | L 4-6 | @ TEX | 4 | 15 | L | 5.2 | 11 | 5 | 5 | 0 | 0 | 3 | 80 | 24 | 56 | 70% | 0-2 | 6.43 | 1.76 |
| 2008-09-03 | Felix Hernandez | R | 22 | L 0-1 | @ TEX | 27 | 100 | L | 7.1 | 7 | 1 | 1 | 0 | 1 | 3 | 102 | 35 | 67 | 66% | 9-9 | 3.19 | 1.33 |
| 2008-09-05 | Brandon Morrow | R | 24 | L 3-1 | vs NYA | 1 | 1 | W | 7.2 | 1 | 1 | 1 | 0 | 3 | 8 | 106 | 34 | 72 | 68% | 2-2 | 1.43 | 0.84 |
| 2008-09-06 | Ryan Rowland-Smith | L | 26 | W 4-7 | vs NYA | 8 | 8 | - | 6.1 | 7 | 3 | 3 | 2 | 4 | 1 | 91 | 35 | 56 | 62% | 4-2 | 3.62 | 1.40 |
| 2008-09-07 | Ryan Feierabend | L | 23 | L 5-2 | vs NYA | 5 | 16 | W | 7.0 | 5 | 2 | 2 | 2 | 3 | 4 | 97 | 38 | 59 | 61% | 1-2 | 5.46 | 1.61 |
| 2008-09-09 | Felix Hernandez | R | 22 | W 3-7 | vs TEX | 28 | 101 | L | 4.1 | 6 | 6 | 6 | 0 | 4 | 3 | 96 | 41 | 55 | 57% | 9-10 | 3.40 | 1.35 |
| 2008-09-10 | Cesar Jimenez | L | 24 | L 8-7 | vs TEX | 1 | 2 | - | 3.0 | 1 | 0 | 0 | 0 | 2 | 4 | 48 | 23 | 25 | 52% | 0-2 | 3.33 | 1.30 |
| 2008-09-11 | Brandon Morrow | R | 24 | L 4-7 | @ ANA | 2 | 2 | L | 5.0 | 5 | 2 | 2 | 0 | 4 | 4 | 97 | 43 | 54 | 56% | 2-3 | 1.65 | 0.94 |
| 2008-09-12 | Ryan Rowland-Smith | L | 26 | L 3-5 | @ ANA | 9 | 9 | - | 6.1 | 4 | 3 | 3 | 0 | 2 | 3 | 95 | 32 | 63 | 66% | 4-2 | 3.64 | 1.36 |
| 2008-09-13 | Ryan Feierabend | L | 23 | L 2-5 | @ ANA | 6 | 17 | L | 5.0 | 7 | 4 | 4 | 1 | 2 | 4 | 82 | 33 | 49 | 60% | 1-3 | 5.73 | 1.64 |
| 2008-09-14 | Felix Hernandez | R | 22 | L 3-4 | @ ANA | 29 | 102 | - | 7.0 | 8 | 3 | 3 | 1 | 4 | 3 | 106 | 42 | 64 | 60% | 9-10 | 3.42 | 1.36 |
| 2008-09-15 | Carlos Silva | R | 29 | L 0-3 | @ KCA | 27 | 152 | L | 5.1 | 8 | 2 | 2 | 0 | 0 | 4 | 97 | 38 | 59 | 61% | 4-15 | 6.42 | 1.59 |
| 2008-09-16 | Brandon Morrow | R | 24 | L 3-6 | @ KCA | 3 | 3 | L | 4.0 | 8 | 6 | 6 | 3 | 2 | 2 | 94 | 40 | 54 | 57% | 2-4 | 2.55 | 1.06 |
| 2008-09-17 | Ryan Rowland-Smith | L | 26 | L 2-5 | @ KCA | 10 | 10 | - | 6.0 | 3 | 1 | 1 | 1 | 4 | 1 | 94 | 39 | 55 | 59% | 4-2 | 3.51 | 1.35 |
| 2008-09-18 | Ryan Feierabend | L | 23 | L 0-12 | @ KCA | 7 | 18 | L | 3.1 | 6 | 8 | 8 | 1 | 3 | 2 | 77 | 35 | 42 | 55% | 1-4 | 7.25 | 1.75 |
| 2008-09-19 | Felix Hernandez | R | 22 | L 0-2 | @ OAK | 30 | 103 | L | 8.0 | 6 | 2 | 2 | 1 | 1 | 8 | 117 | 41 | 76 | 65% | 9-11 | 3.37 | 1.34 |
| 2008-09-20 | Carlos Silva | R | 29 | L 7-8 | @ OAK | 28 | 153 | - | 3.1 | 4 | 4 | 3 | 0 | 2 | 4 | 58 | 22 | 36 | 62% | 4-15 | 6.47 | 1.60 |
| 2008-09-21 | Brandon Morrow | R | 24 | L 3-5 | @ OAK | 4 | 4 | - | 6.1 | 2 | 3 | 3 | 0 | 5 | 6 | 112 | 47 | 65 | 58% | 2-4 | 2.70 | 1.05 |
| 2008-09-22 | Ryan Rowland-Smith | L | 26 | W 1-2 | vs ANA | 11 | 11 | L | 7.0 | 8 | 2 | 1 | 1 | 1 | 6 | 114 | 38 | 76 | 67% | 4-3 | 3.38 | 1.35 |
| 2008-09-23 | Ryan Feierabend | L | 23 | L 9-6 | vs ANA | 8 | 19 | - | 3.2 | 7 | 5 | 5 | 2 | 3 | 3 | 83 | 36 | 47 | 57% | 1-4 | 7.65 | 1.83 |
| 2008-09-24 | Felix Hernandez | R | 22 | W 5-6 | vs ANA | 31 | 104 | - | 6.0 | 13 | 5 | 4 | 0 | 3 | 4 | 105 | 37 | 68 | 65% | 9-11 | 3.45 | 1.38 |
| 2008-09-25 | Cesar Jimenez | L | 24 | W 4-6 | vs ANA | 2 | 3 | - | 3.2 | 2 | 1 | 1 | 0 | 3 | 0 | 50 | 23 | 27 | 54% | 0-2 | 3.44 | 1.29 |
| 2008-09-26 | Brandon Morrow | R | 24 | L 10-8 | vs OAK | 5 | 5 | W | 5.0 | 6 | 6 | 6 | 2 | 5 | 8 | 112 | 50 | 62 | 55% | 3-4 | 3.32 | 1.14 |
| 2008-09-27 | Ryan Rowland-Smith | L | 26 | L 7-3 | vs OAK | 12 | 12 | W | 6.2 | 9 | 3 | 3 | 0 | 2 | 5 | 113 | 41 | 72 | 64% | 5-3 | 3.43 | 1.37 |
| 2008-09-28 | R.A. Dickey | R | 34 | L 4-3 | vs OAK | 14 | 47 | W | 5.2 | 6 | 3 | 3 | 1 | 1 | 2 | 98 | 36 | 62 | 63% | 5-8 | 5.22 | 1.56 |