| Central | W | L | Pct | GB |
| Chi Cubs | 97 | 64 | .602 | -- |
| Milwaukee | 90 | 72 | .556 | 7.5 |
| Houston | 86 | 75 | .534 | 11.0 |
| St. Louis | 86 | 76 | .531 | 11.5 |
| Cincinnati | 74 | 88 | .457 | 23.5 |
| Pittsburgh | 67 | 95 | .414 | 30.5 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2008-03-31 | Ben Sheets | R | 30 | W 4-3 | @ CHN | 1 | 191 | - | 6.1 | 2 | 0 | 0 | 0 | 2 | 7 | 98 | 33 | 65 | 66% | 0-0 | 0.00 | 0.67 |
| 2008-04-02 | Jeff Suppan | R | 33 | W 8-2 | @ CHN | 1 | 336 | W | 6.1 | 6 | 2 | 2 | 2 | 2 | 2 | 109 | 47 | 62 | 57% | 1-0 | 3.00 | 1.33 |
| 2008-04-03 | David Bush | R | 28 | L 3-6 | @ CHN | 1 | 104 | L | 5.1 | 6 | 6 | 6 | 1 | 5 | 4 | 105 | 49 | 56 | 53% | 0-1 | 10.80 | 2.20 |
| 2008-04-04 | Carlos Villanueva | R | 24 | L 13-4 | vs SFN | 1 | 13 | W | 5.1 | 8 | 2 | 2 | 0 | 2 | 6 | 103 | 37 | 66 | 64% | 1-0 | 3.60 | 2.00 |
| 2008-04-05 | Manny Parra | L | 25 | L 5-4 | vs SFN | 1 | 3 | W | 5.1 | 3 | 2 | 2 | 0 | 2 | 7 | 95 | 35 | 60 | 63% | 1-0 | 3.60 | 1.00 |
| 2008-04-06 | Ben Sheets | R | 30 | L 7-0 | vs SFN | 2 | 192 | W | 9.0 | 5 | 0 | 0 | 0 | 0 | 8 | 109 | 31 | 78 | 72% | 1-0 | 0.00 | 0.60 |
| 2008-04-08 | Jeff Suppan | R | 33 | L 3-2 | vs CIN | 2 | 337 | - | 7.0 | 6 | 1 | 1 | 0 | 2 | 1 | 93 | 39 | 54 | 58% | 1-0 | 2.08 | 1.23 |
| 2008-04-09 | David Bush | R | 28 | W 4-12 | vs CIN | 2 | 105 | L | 5.1 | 6 | 5 | 4 | 0 | 3 | 4 | 95 | 41 | 54 | 57% | 0-2 | 8.18 | 1.82 |
| 2008-04-10 | Carlos Villanueva | R | 24 | W 1-4 | vs CIN | 2 | 14 | L | 6.0 | 7 | 4 | 4 | 1 | 3 | 4 | 93 | 37 | 56 | 60% | 1-1 | 4.91 | 1.82 |
| 2008-04-11 | Manny Parra | L | 25 | L 2-4 | @ NYN | 2 | 4 | L | 4.0 | 6 | 3 | 3 | 0 | 1 | 4 | 76 | 31 | 45 | 59% | 1-1 | 5.00 | 1.33 |
| 2008-04-12 | Ben Sheets | R | 30 | W 5-3 | @ NYN | 3 | 193 | W | 7.2 | 5 | 3 | 3 | 1 | 2 | 5 | 118 | 43 | 75 | 64% | 2-0 | 1.17 | 0.70 |
| 2008-04-13 | Jeff Suppan | R | 33 | W 9-7 | @ NYN | 3 | 338 | - | 4.0 | 9 | 6 | 6 | 1 | 2 | 2 | 79 | 34 | 45 | 57% | 1-0 | 4.76 | 1.59 |
| 2008-04-15 | David Bush | R | 28 | L 1-6 | @ SLN | 3 | 106 | L | 6.0 | 6 | 3 | 3 | 0 | 2 | 5 | 93 | 36 | 57 | 61% | 0-3 | 6.88 | 1.65 |
| 2008-04-16 | Carlos Villanueva | R | 24 | L 4-5 | @ SLN | 3 | 15 | L | 4.2 | 8 | 5 | 5 | 2 | 2 | 0 | 120 | 51 | 69 | 58% | 1-2 | 6.19 | 1.88 |
| 2008-04-17 | Manny Parra | L | 25 | W 5-3 | @ SLN | 3 | 5 | - | 4.0 | 5 | 3 | 3 | 1 | 5 | 3 | 80 | 43 | 37 | 46% | 1-1 | 5.54 | 1.69 |
| 2008-04-18 | Ben Sheets | R | 30 | W 5-2 | @ CIN | 4 | 194 | W | 5.0 | 2 | 0 | 0 | 0 | 0 | 4 | 63 | 22 | 41 | 65% | 3-0 | 0.96 | 0.64 |
| 2008-04-19 | Jeff Suppan | R | 33 | W 5-3 | @ CIN | 4 | 339 | - | 6.2 | 3 | 2 | 2 | 0 | 1 | 3 | 86 | 26 | 60 | 70% | 1-0 | 4.13 | 1.29 |
| 2008-04-20 | Yovani Gallardo | R | 22 | L 3-4 | @ CIN | 1 | 18 | - | 7.0 | 4 | 1 | 1 | 1 | 3 | 4 | 112 | 44 | 68 | 61% | 0-0 | 1.29 | 1.00 |
| 2008-04-21 | Carlos Villanueva | R | 24 | W 3-4 | vs SLN | 4 | 16 | - | 7.0 | 3 | 2 | 2 | 0 | 4 | 1 | 98 | 42 | 56 | 57% | 1-2 | 5.09 | 1.61 |
| 2008-04-22 | Manny Parra | L | 25 | L 9-8 | vs SLN | 4 | 6 | - | 5.0 | 9 | 3 | 3 | 0 | 2 | 2 | 106 | 46 | 60 | 57% | 1-1 | 5.50 | 1.83 |
| 2008-04-23 | David Bush | R | 28 | L 5-4 | vs PHI | 4 | 107 | - | 6.0 | 8 | 4 | 4 | 3 | 2 | 3 | 107 | 44 | 63 | 59% | 0-3 | 6.65 | 1.65 |
| 2008-04-24 | Jeff Suppan | R | 33 | W 1-3 | vs PHI | 5 | 340 | - | 7.0 | 5 | 1 | 1 | 1 | 3 | 3 | 90 | 41 | 49 | 54% | 1-0 | 3.48 | 1.26 |
| 2008-04-25 | Yovani Gallardo | R | 22 | W 0-3 | vs FLO | 2 | 19 | - | 7.0 | 6 | 0 | 0 | 0 | 2 | 5 | 115 | 47 | 68 | 59% | 0-0 | 0.64 | 1.07 |
| 2008-04-26 | Carlos Villanueva | R | 24 | L 4-3 | vs FLO | 5 | 17 | - | 6.0 | 6 | 2 | 2 | 1 | 0 | 5 | 104 | 34 | 70 | 67% | 1-2 | 4.66 | 1.48 |
| 2008-04-27 | Manny Parra | L | 25 | W 2-3 | vs FLO | 5 | 7 | - | 5.1 | 6 | 2 | 2 | 0 | 3 | 3 | 97 | 41 | 56 | 58% | 1-1 | 4.88 | 1.75 |
| 2008-04-29 | Ben Sheets | R | 30 | W 10-7 | @ CHN | 5 | 195 | W | 5.0 | 3 | 4 | 3 | 1 | 7 | 2 | 112 | 50 | 62 | 55% | 4-0 | 1.64 | 0.85 |
| 2008-04-30 | Jeff Suppan | R | 33 | L 5-19 | @ CHN | 6 | 341 | L | 3.2 | 11 | 11 | 8 | 1 | 1 | 1 | 94 | 36 | 58 | 62% | 1-1 | 5.14 | 1.46 |
| 2008-05-01 | Yovani Gallardo | R | 22 | W 4-3 | @ CHN | 3 | 20 | - | 6.0 | 9 | 3 | 3 | 1 | 1 | 4 | 89 | 30 | 59 | 66% | 0-0 | 1.80 | 1.25 |
| 2008-05-02 | Carlos Villanueva | R | 24 | L 4-7 | @ HOU | 6 | 18 | L | 5.0 | 9 | 6 | 6 | 4 | 0 | 4 | 82 | 24 | 58 | 71% | 1-3 | 5.56 | 1.53 |
| 2008-05-03 | Manny Parra | L | 26 | L 2-6 | @ HOU | 6 | 8 | L | 4.0 | 9 | 6 | 5 | 2 | 4 | 3 | 98 | 45 | 53 | 54% | 1-2 | 5.79 | 1.96 |
| 2008-05-04 | Ben Sheets | R | 30 | L 6-8 | @ HOU | 6 | 196 | - | 6.1 | 7 | 4 | 4 | 1 | 0 | 6 | 111 | 34 | 77 | 69% | 4-0 | 2.31 | 0.90 |
| 2008-05-06 | Jeff Suppan | R | 33 | L 0-3 | @ FLO | 7 | 342 | L | 5.0 | 8 | 3 | 3 | 1 | 3 | 5 | 110 | 44 | 66 | 60% | 1-2 | 5.18 | 1.55 |
| 2008-05-07 | David Bush | R | 28 | L 2-6 | @ FLO | 5 | 108 | L | 6.0 | 5 | 6 | 6 | 2 | 2 | 3 | 81 | 36 | 45 | 56% | 0-4 | 6.90 | 1.53 |
| 2008-05-08 | Carlos Villanueva | R | 24 | L 2-7 | @ FLO | 7 | 19 | L | 5.0 | 10 | 7 | 7 | 2 | 2 | 6 | 103 | 36 | 67 | 65% | 1-4 | 6.46 | 1.64 |
| 2008-05-09 | Manny Parra | L | 26 | L 4-3 | vs SLN | 7 | 9 | - | 5.0 | 3 | 3 | 3 | 1 | 3 | 4 | 83 | 39 | 44 | 53% | 1-2 | 5.73 | 1.85 |
| 2008-05-10 | Ben Sheets | R | 30 | W 3-5 | vs SLN | 7 | 197 | - | 7.0 | 9 | 3 | 3 | 1 | 1 | 6 | 92 | 26 | 66 | 72% | 4-0 | 2.54 | 0.98 |
| 2008-05-11 | Jeff Suppan | R | 33 | L 5-3 | vs SLN | 8 | 343 | W | 7.0 | 6 | 1 | 1 | 0 | 5 | 4 | 109 | 47 | 62 | 57% | 2-2 | 4.60 | 1.55 |
| 2008-05-12 | David Bush | R | 29 | L 8-3 | vs SLN | 6 | 109 | W | 6.0 | 4 | 1 | 1 | 1 | 2 | 1 | 87 | 30 | 57 | 66% | 1-4 | 6.00 | 1.44 |
| 2008-05-13 | Carlos Villanueva | R | 24 | L 5-3 | vs LAN | 8 | 20 | W | 6.0 | 8 | 3 | 2 | 0 | 0 | 2 | 82 | 31 | 51 | 62% | 2-4 | 6.00 | 1.60 |
| 2008-05-14 | Manny Parra | L | 26 | W 4-6 | vs LAN | 8 | 10 | - | 6.2 | 7 | 3 | 1 | 1 | 2 | 4 | 101 | 39 | 62 | 61% | 1-2 | 5.08 | 1.79 |
| 2008-05-15 | Ben Sheets | R | 30 | W 2-7 | vs LAN | 8 | 198 | L | 6.1 | 9 | 6 | 6 | 3 | 0 | 5 | 87 | 30 | 57 | 66% | 4-1 | 3.23 | 1.02 |
| 2008-05-17 | Jeff Suppan | R | 33 | L 3-5 | @ BOS | 9 | 344 | L | 6.0 | 9 | 4 | 4 | 1 | 2 | 1 | 97 | 36 | 61 | 63% | 2-3 | 4.75 | 1.58 |
| 2008-05-17 | David Bush | R | 29 | L 6-7 | @ BOS | 7 | 110 | - | 6.0 | 5 | 5 | 4 | 1 | 2 | 2 | 106 | 37 | 69 | 65% | 1-4 | 6.00 | 1.40 |
| 2008-05-18 | Carlos Villanueva | R | 24 | L 7-11 | @ BOS | 9 | 21 | L | 4.0 | 5 | 6 | 5 | 2 | 3 | 3 | 86 | 33 | 53 | 62% | 2-5 | 6.43 | 1.63 |
| 2008-05-20 | Manny Parra | L | 26 | W 7-2 | @ PIT | 9 | 11 | W | 5.2 | 4 | 0 | 0 | 0 | 1 | 6 | 121 | 43 | 78 | 64% | 2-2 | 4.40 | 1.67 |
| 2008-05-21 | Ben Sheets | R | 30 | W 4-1 | @ PIT | 9 | 199 | W | 9.0 | 11 | 1 | 1 | 1 | 0 | 6 | 123 | 38 | 85 | 69% | 5-1 | 2.90 | 1.05 |
| 2008-05-22 | David Bush | R | 29 | L 4-8 | @ PIT | 8 | 111 | L | 5.0 | 9 | 6 | 6 | 2 | 0 | 1 | 75 | 21 | 54 | 72% | 1-5 | 6.51 | 1.45 |
| 2008-05-23 | Jeff Suppan | R | 33 | L 1-5 | @ WAS | 10 | 345 | L | 5.2 | 3 | 5 | 1 | 1 | 3 | 4 | 88 | 39 | 49 | 56% | 2-4 | 4.50 | 1.55 |
| 2008-05-24 | Seth McClung | R | 27 | W 5-2 | @ WAS | 1 | 38 | W | 5.0 | 4 | 2 | 2 | 1 | 0 | 4 | 69 | 24 | 45 | 65% | 2-1 | 3.60 | 1.28 |
| 2008-05-25 | Manny Parra | L | 26 | L 6-7 | @ WAS | 10 | 12 | - | 4.1 | 7 | 6 | 6 | 1 | 3 | 3 | 94 | 36 | 58 | 62% | 2-2 | 5.14 | 1.73 |
| 2008-05-26 | Ben Sheets | R | 30 | W 4-3 | @ WAS | 10 | 200 | - | 6.0 | 7 | 2 | 2 | 1 | 0 | 6 | 84 | 25 | 59 | 70% | 5-1 | 2.91 | 1.06 |
| 2008-05-27 | David Bush | R | 29 | L 3-2 | vs ATL | 9 | 112 | - | 7.0 | 6 | 2 | 2 | 2 | 1 | 3 | 91 | 35 | 56 | 62% | 1-5 | 6.00 | 1.39 |
| 2008-05-28 | Jeff Suppan | R | 33 | L 1-0 | vs ATL | 11 | 346 | W | 8.0 | 4 | 0 | 0 | 0 | 5 | 7 | 113 | 44 | 69 | 61% | 3-4 | 3.95 | 1.50 |
| 2008-05-29 | Seth McClung | R | 27 | W 1-8 | vs ATL | 2 | 39 | L | 4.2 | 8 | 6 | 6 | 1 | 6 | 1 | 85 | 44 | 41 | 48% | 2-2 | 4.80 | 1.53 |
| 2008-05-30 | Manny Parra | L | 26 | L 5-1 | vs HOU | 11 | 13 | W | 6.0 | 4 | 1 | 1 | 0 | 4 | 6 | 87 | 37 | 50 | 57% | 3-2 | 4.75 | 1.69 |
| 2008-05-31 | Ben Sheets | R | 30 | L 4-1 | vs HOU | 11 | 201 | W | 8.2 | 7 | 1 | 1 | 0 | 1 | 5 | 120 | 34 | 86 | 72% | 6-1 | 2.72 | 1.05 |
| 2008-06-01 | David Bush | R | 29 | L 10-1 | vs HOU | 10 | 113 | W | 7.0 | 4 | 1 | 1 | 1 | 0 | 5 | 103 | 36 | 67 | 65% | 2-5 | 5.46 | 1.30 |
| 2008-06-02 | Jeff Suppan | R | 33 | L 4-3 | vs ARI | 12 | 347 | - | 7.0 | 7 | 3 | 3 | 1 | 2 | 6 | 96 | 37 | 59 | 61% | 3-4 | 3.95 | 1.48 |
| 2008-06-03 | Seth McClung | R | 27 | L 7-1 | vs ARI | 3 | 40 | W | 6.0 | 6 | 1 | 1 | 0 | 0 | 4 | 76 | 26 | 50 | 66% | 3-2 | 4.25 | 1.44 |
| 2008-06-04 | Manny Parra | L | 26 | L 10-1 | vs ARI | 12 | 14 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 8 | 100 | 34 | 66 | 66% | 4-2 | 4.35 | 1.60 |
| 2008-06-06 | Ben Sheets | R | 30 | L 4-6 | @ COL | 12 | 202 | - | 6.0 | 5 | 1 | 1 | 0 | 2 | 3 | 101 | 42 | 59 | 58% | 6-1 | 2.63 | 1.06 |
| 2008-06-07 | David Bush | R | 29 | L 2-7 | @ COL | 11 | 114 | L | 4.0 | 5 | 5 | 5 | 2 | 2 | 3 | 69 | 26 | 43 | 62% | 2-6 | 5.82 | 1.32 |
| 2008-06-08 | Jeff Suppan | R | 33 | W 3-2 | @ COL | 13 | 348 | W | 5.1 | 4 | 2 | 1 | 0 | 5 | 3 | 100 | 48 | 52 | 52% | 4-4 | 3.76 | 1.48 |
| 2008-06-10 | Seth McClung | R | 27 | L 1-6 | @ HOU | 4 | 41 | L | 6.0 | 3 | 2 | 2 | 1 | 1 | 5 | 92 | 35 | 57 | 62% | 3-3 | 4.07 | 1.33 |
| 2008-06-11 | Manny Parra | L | 26 | W 10-6 | @ HOU | 13 | 15 | W | 5.1 | 10 | 5 | 5 | 3 | 0 | 3 | 83 | 29 | 54 | 65% | 5-2 | 4.63 | 1.60 |
| 2008-06-12 | Ben Sheets | R | 30 | W 9-6 | @ HOU | 13 | 203 | W | 7.0 | 7 | 3 | 3 | 2 | 2 | 9 | 120 | 48 | 72 | 60% | 7-1 | 2.73 | 1.08 |
| 2008-06-13 | David Bush | R | 29 | W 2-10 | vs MIN | 12 | 115 | L | 6.0 | 10 | 4 | 3 | 0 | 1 | 3 | 88 | 31 | 57 | 65% | 2-7 | 5.70 | 1.37 |
| 2008-06-14 | Jeff Suppan | R | 33 | W 4-9 | vs MIN | 14 | 349 | - | 7.0 | 7 | 2 | 2 | 0 | 1 | 5 | 96 | 38 | 58 | 60% | 4-4 | 3.66 | 1.45 |
| 2008-06-15 | Seth McClung | R | 27 | L 4-2 | vs MIN | 5 | 42 | W | 6.0 | 4 | 2 | 2 | 1 | 0 | 4 | 78 | 24 | 54 | 69% | 4-3 | 3.94 | 1.25 |
| 2008-06-17 | Manny Parra | L | 26 | L 7-0 | vs TOR | 14 | 16 | W | 7.0 | 4 | 0 | 0 | 0 | 4 | 5 | 106 | 43 | 63 | 59% | 6-2 | 4.20 | 1.56 |
| 2008-06-18 | Ben Sheets | R | 30 | L 5-4 | vs TOR | 14 | 204 | W | 6.0 | 4 | 2 | 2 | 0 | 4 | 5 | 107 | 48 | 59 | 55% | 8-1 | 2.75 | 1.09 |
| 2008-06-19 | David Bush | R | 29 | L 8-7 | vs TOR | 13 | 116 | W | 8.0 | 2 | 1 | 1 | 0 | 1 | 2 | 106 | 38 | 68 | 64% | 3-7 | 5.24 | 1.27 |
| 2008-06-20 | Jeff Suppan | R | 33 | W 5-8 | vs BAL | 15 | 350 | L | 1.2 | 7 | 6 | 3 | 0 | 2 | 1 | 54 | 23 | 31 | 57% | 4-5 | 3.93 | 1.54 |
| 2008-06-21 | Seth McClung | R | 27 | L 3-2 | vs BAL | 6 | 43 | W | 6.2 | 3 | 2 | 2 | 1 | 5 | 6 | 103 | 46 | 57 | 55% | 5-3 | 3.76 | 1.24 |
| 2008-06-22 | Manny Parra | L | 26 | L 7-3 | vs BAL | 15 | 17 | W | 5.0 | 5 | 3 | 3 | 0 | 6 | 1 | 90 | 41 | 49 | 54% | 7-2 | 4.28 | 1.60 |
| 2008-06-23 | Ben Sheets | R | 30 | W 4-1 | @ ATL | 15 | 205 | W | 9.0 | 4 | 1 | 1 | 0 | 0 | 7 | 105 | 33 | 72 | 69% | 9-1 | 2.60 | 1.04 |
| 2008-06-24 | David Bush | R | 29 | W 4-3 | @ ATL | 14 | 117 | W | 7.0 | 4 | 1 | 1 | 0 | 1 | 5 | 98 | 35 | 63 | 64% | 4-7 | 4.92 | 1.22 |
| 2008-06-25 | Jeff Suppan | R | 33 | L 2-4 | @ ATL | 16 | 351 | L | 6.0 | 9 | 4 | 4 | 0 | 1 | 5 | 93 | 30 | 63 | 68% | 4-6 | 4.06 | 1.55 |
| 2008-06-27 | Seth McClung | R | 27 | L 6-7 | @ MIN | 7 | 44 | - | 4.2 | 9 | 5 | 5 | 2 | 2 | 2 | 88 | 32 | 56 | 64% | 5-3 | 4.27 | 1.34 |
| 2008-06-28 | Manny Parra | L | 26 | W 5-1 | @ MIN | 16 | 18 | W | 7.0 | 2 | 0 | 0 | 0 | 4 | 6 | 115 | 50 | 65 | 57% | 8-2 | 3.93 | 1.54 |
| 2008-06-29 | Ben Sheets | R | 30 | L 0-5 | @ MIN | 16 | 206 | L | 7.0 | 9 | 5 | 5 | 1 | 2 | 7 | 115 | 41 | 74 | 64% | 9-2 | 2.84 | 1.07 |
| 2008-06-30 | David Bush | R | 29 | L 3-6 | @ ARI | 15 | 118 | L | 5.0 | 9 | 5 | 4 | 0 | 2 | 1 | 78 | 33 | 45 | 58% | 4-8 | 5.04 | 1.27 |
| 2008-07-01 | Jeff Suppan | R | 33 | W 8-6 | @ ARI | 17 | 352 | W | 5.0 | 9 | 5 | 5 | 1 | 2 | 0 | 76 | 32 | 44 | 58% | 5-6 | 4.32 | 1.58 |
| 2008-07-02 | Seth McClung | R | 27 | W 4-3 | @ ARI | 8 | 45 | - | 5.1 | 8 | 2 | 2 | 0 | 1 | 6 | 98 | 40 | 58 | 59% | 5-3 | 4.15 | 1.35 |
| 2008-07-03 | Manny Parra | L | 26 | L 5-6 | @ ARI | 17 | 19 | - | 6.0 | 4 | 0 | 0 | 0 | 3 | 4 | 100 | 41 | 59 | 59% | 8-2 | 3.68 | 1.52 |
| 2008-07-04 | Ben Sheets | R | 30 | L 9-1 | vs PIT | 17 | 207 | W | 5.2 | 8 | 1 | 1 | 0 | 3 | 6 | 120 | 39 | 81 | 68% | 10-2 | 2.77 | 1.11 |
| 2008-07-05 | David Bush | R | 29 | L 2-1 | vs PIT | 16 | 119 | - | 8.0 | 4 | 1 | 1 | 0 | 0 | 7 | 99 | 32 | 67 | 68% | 4-8 | 4.73 | 1.21 |
| 2008-07-06 | Jeff Suppan | R | 34 | L 11-6 | vs PIT | 18 | 353 | - | 3.0 | 5 | 6 | 6 | 2 | 2 | 2 | 75 | 31 | 44 | 59% | 5-6 | 4.72 | 1.60 |
| 2008-07-07 | Seth McClung | R | 27 | W 3-4 | vs COL | 9 | 46 | L | 4.2 | 3 | 2 | 2 | 0 | 5 | 5 | 87 | 38 | 49 | 56% | 5-4 | 4.17 | 1.39 |
| 2008-07-08 | C.C. Sabathia | L | 28 | L 7-3 | vs COL | 19 | 238 | W | 6.0 | 5 | 3 | 2 | 0 | 5 | 5 | 96 | 40 | 56 | 58% | 7-8 | 3.80 | 1.26 |
| 2008-07-09 | Ben Sheets | R | 30 | W 3-8 | vs COL | 18 | 208 | L | 6.0 | 5 | 3 | 3 | 1 | 2 | 11 | 109 | 40 | 69 | 63% | 10-3 | 2.85 | 1.11 |
| 2008-07-10 | David Bush | R | 29 | L 11-1 | vs COL | 17 | 120 | W | 8.0 | 3 | 1 | 0 | 0 | 0 | 13 | 123 | 38 | 85 | 69% | 5-8 | 4.37 | 1.15 |
| 2008-07-11 | Manny Parra | L | 26 | W 5-6 | vs CIN | 18 | 20 | - | 6.1 | 6 | 5 | 4 | 0 | 1 | 6 | 89 | 33 | 56 | 63% | 8-2 | 3.78 | 1.49 |
| 2008-07-12 | Seth McClung | R | 27 | W 2-8 | vs CIN | 10 | 47 | L | 6.1 | 3 | 3 | 3 | 1 | 3 | 7 | 96 | 36 | 60 | 63% | 5-5 | 4.14 | 1.34 |
| 2008-07-13 | C.C. Sabathia | L | 28 | L 3-2 | vs CIN | 20 | 239 | W | 9.0 | 8 | 2 | 2 | 0 | 1 | 9 | 121 | 40 | 81 | 67% | 8-8 | 3.68 | 1.24 |
| 2008-07-18 | C.C. Sabathia | L | 28 | W 9-1 | @ SFN | 21 | 240 | W | 9.0 | 4 | 1 | 1 | 1 | 0 | 10 | 109 | 32 | 77 | 71% | 9-8 | 3.51 | 1.19 |
| 2008-07-19 | Ben Sheets | R | 30 | W 8-5 | @ SFN | 19 | 209 | - | 5.0 | 9 | 4 | 2 | 0 | 1 | 3 | 85 | 29 | 56 | 66% | 10-3 | 2.88 | 1.15 |
| 2008-07-20 | Manny Parra | L | 26 | W 7-4 | @ SFN | 19 | 21 | W | 7.2 | 7 | 2 | 2 | 0 | 2 | 9 | 103 | 33 | 70 | 68% | 9-2 | 3.67 | 1.46 |
| 2008-07-21 | Seth McClung | R | 27 | W 6-3 | @ SLN | 11 | 48 | - | 5.0 | 5 | 2 | 2 | 0 | 2 | 5 | 89 | 36 | 53 | 60% | 5-5 | 4.11 | 1.35 |
| 2008-07-22 | Jeff Suppan | R | 34 | W 4-3 | @ SLN | 19 | 354 | - | 7.0 | 8 | 3 | 3 | 1 | 2 | 3 | 94 | 38 | 56 | 60% | 5-6 | 4.67 | 1.59 |
| 2008-07-23 | C.C. Sabathia | L | 28 | W 3-0 | @ SLN | 22 | 241 | W | 9.0 | 3 | 0 | 0 | 0 | 2 | 7 | 106 | 35 | 71 | 67% | 10-8 | 3.31 | 1.15 |
| 2008-07-24 | Ben Sheets | R | 30 | W 4-3 | @ SLN | 20 | 210 | - | 7.0 | 4 | 3 | 2 | 0 | 2 | 4 | 99 | 35 | 64 | 65% | 10-3 | 2.87 | 1.13 |
| 2008-07-25 | Manny Parra | L | 26 | W 1-3 | vs HOU | 20 | 22 | L | 6.0 | 8 | 3 | 3 | 0 | 2 | 5 | 95 | 40 | 55 | 58% | 9-3 | 3.71 | 1.47 |
| 2008-07-26 | David Bush | R | 29 | L 6-4 | vs HOU | 18 | 121 | - | 5.0 | 9 | 4 | 4 | 2 | 0 | 5 | 88 | 31 | 57 | 65% | 5-8 | 4.50 | 1.18 |
| 2008-07-27 | Jeff Suppan | R | 34 | W 6-11 | vs HOU | 20 | 355 | L | 6.0 | 11 | 8 | 8 | 2 | 1 | 3 | 90 | 27 | 63 | 70% | 5-7 | 5.05 | 1.61 |
| 2008-07-28 | C.C. Sabathia | L | 28 | W 4-6 | vs CHN | 23 | 242 | - | 6.2 | 9 | 4 | 3 | 1 | 2 | 3 | 121 | 47 | 74 | 61% | 10-8 | 3.33 | 1.17 |
| 2008-07-29 | Ben Sheets | R | 30 | W 1-7 | vs CHN | 21 | 211 | L | 5.1 | 11 | 6 | 6 | 0 | 1 | 4 | 100 | 35 | 65 | 65% | 10-4 | 3.15 | 1.18 |
| 2008-07-30 | Manny Parra | L | 26 | W 2-7 | vs CHN | 21 | 23 | L | 5.1 | 8 | 5 | 5 | 0 | 4 | 5 | 96 | 40 | 56 | 58% | 9-4 | 3.93 | 1.51 |
| 2008-07-31 | David Bush | R | 29 | W 4-11 | vs CHN | 19 | 122 | L | 7.1 | 5 | 7 | 6 | 3 | 1 | 3 | 102 | 40 | 62 | 61% | 5-9 | 4.69 | 1.16 |
| 2008-08-01 | Jeff Suppan | R | 34 | W 9-0 | @ ATL | 21 | 356 | W | 7.0 | 5 | 0 | 0 | 0 | 3 | 1 | 101 | 38 | 63 | 62% | 6-7 | 4.76 | 1.59 |
| 2008-08-02 | C.C. Sabathia | L | 28 | W 4-2 | @ ATL | 24 | 243 | W | 8.1 | 6 | 2 | 2 | 0 | 1 | 9 | 107 | 31 | 76 | 71% | 11-8 | 3.28 | 1.16 |
| 2008-08-03 | Ben Sheets | R | 30 | L 0-5 | @ ATL | 22 | 212 | L | 6.0 | 6 | 3 | 2 | 0 | 3 | 4 | 98 | 30 | 68 | 69% | 10-5 | 3.14 | 1.19 |
| 2008-08-04 | Manny Parra | L | 26 | L 3-6 | @ CIN | 22 | 24 | L | 6.0 | 4 | 6 | 6 | 1 | 4 | 6 | 105 | 41 | 64 | 61% | 9-5 | 4.18 | 1.50 |
| 2008-08-05 | David Bush | R | 29 | W 8-1 | @ CIN | 20 | 123 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 7 | 91 | 30 | 61 | 67% | 6-9 | 4.50 | 1.13 |
| 2008-08-06 | Jeff Suppan | R | 34 | W 6-3 | @ CIN | 22 | 357 | W | 7.0 | 7 | 3 | 3 | 1 | 0 | 3 | 97 | 40 | 57 | 59% | 7-7 | 4.71 | 1.55 |
| 2008-08-08 | C.C. Sabathia | L | 28 | L 5-0 | vs WAS | 25 | 244 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 9 | 102 | 26 | 76 | 75% | 12-8 | 3.12 | 1.13 |
| 2008-08-09 | Ben Sheets | R | 30 | L 6-0 | vs WAS | 23 | 213 | W | 9.0 | 5 | 0 | 0 | 0 | 0 | 6 | 113 | 35 | 78 | 69% | 11-5 | 2.96 | 1.15 |
| 2008-08-10 | Manny Parra | L | 26 | L 5-4 | vs WAS | 23 | 25 | - | 7.0 | 6 | 1 | 1 | 0 | 0 | 9 | 91 | 27 | 64 | 70% | 9-5 | 4.02 | 1.47 |
| 2008-08-11 | David Bush | R | 29 | L 7-1 | vs WAS | 21 | 124 | W | 6.1 | 5 | 1 | 1 | 0 | 2 | 6 | 92 | 31 | 61 | 66% | 7-9 | 4.36 | 1.14 |
| 2008-08-12 | Jeff Suppan | R | 34 | W 5-2 | @ SDN | 23 | 358 | W | 8.0 | 4 | 2 | 2 | 2 | 2 | 3 | 98 | 35 | 63 | 64% | 8-7 | 4.57 | 1.51 |
| 2008-08-13 | C.C. Sabathia | L | 28 | W 7-1 | @ SDN | 26 | 245 | W | 7.0 | 9 | 1 | 1 | 0 | 1 | 8 | 114 | 45 | 69 | 61% | 13-8 | 3.05 | 1.15 |
| 2008-08-14 | Ben Sheets | R | 30 | L 2-3 | @ SDN | 24 | 214 | L | 6.2 | 5 | 3 | 3 | 0 | 2 | 4 | 111 | 40 | 71 | 64% | 11-6 | 3.00 | 1.15 |
| 2008-08-15 | Manny Parra | L | 26 | L 3-5 | @ LAN | 24 | 26 | L | 5.2 | 10 | 4 | 4 | 1 | 1 | 6 | 93 | 31 | 62 | 67% | 9-6 | 4.11 | 1.49 |
| 2008-08-16 | David Bush | R | 29 | W 4-3 | @ LAN | 22 | 125 | - | 7.0 | 5 | 2 | 2 | 1 | 1 | 3 | 71 | 24 | 47 | 66% | 7-9 | 4.27 | 1.12 |
| 2008-08-17 | Jeff Suppan | R | 34 | L 5-7 | @ LAN | 24 | 359 | - | 6.0 | 9 | 4 | 4 | 3 | 2 | 4 | 90 | 37 | 53 | 59% | 8-7 | 4.63 | 1.52 |
| 2008-08-18 | C.C. Sabathia | L | 28 | L 9-3 | vs HOU | 27 | 246 | W | 9.0 | 11 | 3 | 2 | 2 | 2 | 9 | 129 | 42 | 87 | 67% | 14-8 | 3.00 | 1.16 |
| 2008-08-19 | Ben Sheets | R | 30 | W 2-5 | vs HOU | 25 | 215 | L | 6.0 | 5 | 5 | 5 | 1 | 1 | 7 | 93 | 30 | 63 | 68% | 11-7 | 3.16 | 1.14 |
| 2008-08-20 | Manny Parra | L | 26 | L 5-2 | vs HOU | 25 | 27 | W | 5.0 | 6 | 2 | 2 | 0 | 4 | 2 | 92 | 41 | 51 | 55% | 10-6 | 4.09 | 1.50 |
| 2008-08-22 | David Bush | R | 29 | L 10-4 | vs PIT | 23 | 126 | W | 7.0 | 7 | 3 | 3 | 1 | 1 | 2 | 94 | 32 | 62 | 66% | 8-9 | 4.25 | 1.12 |
| 2008-08-23 | Jeff Suppan | R | 34 | L 6-3 | vs PIT | 25 | 360 | W | 7.0 | 8 | 3 | 3 | 1 | 0 | 3 | 97 | 35 | 62 | 64% | 9-7 | 4.59 | 1.50 |
| 2008-08-24 | C.C. Sabathia | L | 28 | L 4-3 | vs PIT | 28 | 247 | - | 6.0 | 8 | 1 | 1 | 0 | 0 | 5 | 95 | 32 | 63 | 66% | 14-8 | 2.96 | 1.16 |
| 2008-08-26 | Ben Sheets | R | 30 | W 12-0 | @ SLN | 26 | 216 | W | 6.0 | 5 | 0 | 0 | 0 | 2 | 4 | 103 | 41 | 62 | 60% | 12-7 | 3.05 | 1.14 |
| 2008-08-27 | Manny Parra | L | 26 | L 3-5 | @ SLN | 26 | 28 | - | 6.0 | 6 | 1 | 1 | 1 | 0 | 7 | 97 | 33 | 64 | 66% | 10-6 | 3.99 | 1.48 |
| 2008-08-29 | David Bush | R | 29 | W 3-1 | @ PIT | 24 | 127 | W | 6.2 | 6 | 1 | 1 | 1 | 2 | 2 | 94 | 35 | 59 | 63% | 9-9 | 4.12 | 1.12 |
| 2008-08-30 | Jeff Suppan | R | 34 | W 11-3 | @ PIT | 26 | 361 | W | 7.0 | 3 | 2 | 2 | 1 | 2 | 2 | 101 | 42 | 59 | 58% | 10-7 | 4.50 | 1.47 |
| 2008-08-31 | C.C. Sabathia | L | 28 | W 7-0 | @ PIT | 29 | 248 | W | 9.0 | 1 | 0 | 0 | 0 | 3 | 11 | 121 | 39 | 82 | 68% | 15-8 | 2.83 | 1.13 |
| 2008-09-01 | Ben Sheets | R | 30 | W 2-4 | vs NYN | 27 | 217 | - | 5.0 | 2 | 0 | 0 | 0 | 1 | 0 | 54 | 23 | 31 | 57% | 12-7 | 2.97 | 1.13 |
| 2008-09-02 | Manny Parra | L | 26 | W 5-6 | vs NYN | 27 | 29 | - | 5.0 | 6 | 5 | 4 | 1 | 2 | 6 | 83 | 30 | 53 | 64% | 10-6 | 4.09 | 1.49 |
| 2008-09-03 | David Bush | R | 29 | W 2-9 | vs NYN | 25 | 128 | L | 5.0 | 7 | 6 | 6 | 2 | 3 | 2 | 82 | 38 | 44 | 54% | 9-10 | 4.33 | 1.15 |
| 2008-09-04 | Jeff Suppan | R | 34 | W 2-5 | vs SDN | 27 | 362 | L | 5.1 | 7 | 5 | 4 | 1 | 4 | 3 | 106 | 46 | 60 | 57% | 10-8 | 4.56 | 1.48 |
| 2008-09-05 | C.C. Sabathia | L | 28 | L 3-2 | vs SDN | 30 | 249 | - | 7.0 | 5 | 1 | 1 | 0 | 2 | 9 | 106 | 35 | 71 | 67% | 15-8 | 2.78 | 1.13 |
| 2008-09-06 | Ben Sheets | R | 30 | L 1-0 | vs SDN | 28 | 218 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 7 | 119 | 38 | 81 | 68% | 13-7 | 2.82 | 1.11 |
| 2008-09-07 | Manny Parra | L | 26 | W 1-10 | vs SDN | 28 | 30 | L | 5.0 | 6 | 6 | 1 | 1 | 3 | 5 | 83 | 32 | 51 | 61% | 10-7 | 4.02 | 1.50 |
| 2008-09-08 | David Bush | R | 29 | W 4-5 | vs CIN | 26 | 129 | - | 8.0 | 7 | 2 | 2 | 1 | 2 | 3 | 99 | 32 | 67 | 68% | 9-10 | 4.23 | 1.15 |
| 2008-09-09 | Jeff Suppan | R | 34 | W 4-5 | vs CIN | 28 | 363 | - | 5.1 | 6 | 4 | 4 | 2 | 2 | 2 | 94 | 37 | 57 | 61% | 10-8 | 4.63 | 1.49 |
| 2008-09-10 | C.C. Sabathia | L | 28 | L 4-3 | vs CIN | 31 | 250 | - | 7.0 | 8 | 3 | 3 | 1 | 1 | 8 | 113 | 40 | 73 | 65% | 15-8 | 2.81 | 1.13 |
| 2008-09-11 | Ben Sheets | R | 30 | L 3-6 | @ PHI | 29 | 219 | L | 6.0 | 9 | 5 | 5 | 1 | 3 | 4 | 113 | 43 | 70 | 62% | 13-8 | 2.97 | 1.13 |
| 2008-09-13 | Manny Parra | L | 26 | L 3-7 | @ PHI | 29 | 31 | L | 1.1 | 7 | 5 | 5 | 0 | 3 | 3 | 44 | 25 | 19 | 43% | 10-8 | 4.28 | 1.55 |
| 2008-09-14 | David Bush | R | 29 | L 3-7 | @ PHI | 27 | 130 | - | 6.0 | 5 | 3 | 3 | 1 | 2 | 4 | 80 | 29 | 51 | 64% | 9-10 | 4.24 | 1.15 |
| 2008-09-14 | Jeff Suppan | R | 34 | L 1-6 | @ PHI | 29 | 364 | L | 3.2 | 8 | 6 | 6 | 1 | 4 | 1 | 70 | 33 | 37 | 53% | 10-9 | 4.84 | 1.52 |
| 2008-09-16 | C.C. Sabathia | L | 28 | L 4-5 | @ CHN | 32 | 251 | L | 7.0 | 9 | 4 | 4 | 1 | 0 | 5 | 99 | 29 | 70 | 71% | 15-9 | 2.88 | 1.14 |
| 2008-09-17 | Ben Sheets | R | 30 | W 6-2 | @ CHN | 30 | 220 | - | 2.0 | 1 | 1 | 1 | 1 | 0 | 2 | 24 | 7 | 17 | 71% | 13-8 | 2.98 | 1.13 |
| 2008-09-18 | David Bush | R | 29 | L 6-7 | @ CHN | 28 | 131 | - | 5.0 | 2 | 2 | 2 | 2 | 2 | 3 | 66 | 23 | 43 | 65% | 9-10 | 4.22 | 1.14 |
| 2008-09-19 | Jeff Suppan | R | 34 | L 2-11 | @ CIN | 30 | 365 | L | 2.0 | 5 | 5 | 5 | 2 | 0 | 2 | 43 | 14 | 29 | 67% | 10-10 | 5.05 | 1.53 |
| 2008-09-20 | C.C. Sabathia | L | 28 | L 3-4 | @ CIN | 33 | 252 | L | 5.2 | 7 | 4 | 1 | 0 | 1 | 3 | 105 | 35 | 70 | 67% | 15-10 | 2.85 | 1.14 |
| 2008-09-21 | Seth McClung | R | 28 | W 8-1 | @ CIN | 12 | 49 | - | 3.1 | 2 | 1 | 1 | 0 | 4 | 1 | 78 | 38 | 40 | 51% | 5-6 | 4.19 | 1.45 |
| 2008-09-23 | David Bush | R | 29 | L 7-5 | vs PIT | 29 | 132 | - | 5.0 | 5 | 3 | 3 | 0 | 3 | 2 | 92 | 37 | 55 | 60% | 9-10 | 4.25 | 1.15 |
| 2008-09-24 | C.C. Sabathia | L | 28 | L 4-2 | vs PIT | 34 | 253 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 11 | 106 | 38 | 68 | 64% | 16-10 | 2.80 | 1.14 |
| 2008-09-25 | Yovani Gallardo | R | 23 | L 5-1 | vs PIT | 4 | 21 | - | 4.0 | 3 | 1 | 1 | 1 | 2 | 7 | 66 | 27 | 39 | 59% | 0-0 | 1.88 | 1.25 |
| 2008-09-26 | Jeff Suppan | R | 34 | L 5-1 | vs CHN | 31 | 366 | - | 5.0 | 8 | 1 | 1 | 1 | 1 | 5 | 89 | 34 | 55 | 62% | 10-10 | 4.96 | 1.54 |
| 2008-09-27 | Ben Sheets | R | 30 | W 3-7 | vs CHN | 31 | 221 | L | 2.1 | 5 | 4 | 3 | 1 | 2 | 1 | 53 | 20 | 33 | 62% | 13-9 | 3.09 | 1.15 |
| 2008-09-28 | C.C. Sabathia | L | 28 | L 3-1 | vs CHN | 35 | 254 | W | 9.0 | 4 | 1 | 0 | 0 | 1 | 7 | 122 | 41 | 81 | 66% | 17-10 | 2.70 | 1.11 |