| West | W | L | Pct | GB |
| LA Angels | 100 | 62 | .617 | -- |
| Texas | 79 | 83 | .488 | 21.0 |
| Oakland | 75 | 86 | .466 | 24.5 |
| Seattle | 61 | 101 | .377 | 39.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2008-03-31 | Jered Weaver | R | 25 | L 2-3 | @ MIN | 1 | 48 | L | 6.1 | 8 | 3 | 3 | 0 | 2 | 5 | 114 | 45 | 69 | 61% | 0-1 | 4.50 | 1.67 |
| 2008-04-01 | Jon Garland | R | 29 | W 9-1 | @ MIN | 1 | 224 | W | 8.0 | 6 | 1 | 1 | 0 | 1 | 0 | 96 | 32 | 64 | 67% | 1-0 | 1.13 | 0.88 |
| 2008-04-02 | Joe Saunders | L | 27 | W 1-0 | @ MIN | 1 | 34 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 4 | 81 | 29 | 52 | 64% | 1-0 | 0.00 | 0.63 |
| 2008-04-03 | Ervin Santana | R | 25 | W 5-4 | @ MIN | 1 | 83 | W | 6.0 | 4 | 2 | 2 | 0 | 2 | 3 | 102 | 40 | 62 | 61% | 1-0 | 3.00 | 1.00 |
| 2008-04-04 | Dustin Moseley | R | 26 | W 6-11 | vs TEX | 1 | 11 | L | 5.0 | 6 | 5 | 5 | 1 | 2 | 4 | 90 | 39 | 51 | 57% | 0-1 | 9.00 | 1.60 |
| 2008-04-05 | Jered Weaver | R | 26 | L 2-1 | vs TEX | 2 | 49 | W | 7.0 | 3 | 0 | 0 | 0 | 0 | 6 | 90 | 33 | 57 | 63% | 1-1 | 2.08 | 1.00 |
| 2008-04-06 | Jon Garland | R | 29 | W 4-10 | vs TEX | 2 | 225 | L | 5.0 | 8 | 7 | 7 | 2 | 2 | 2 | 90 | 33 | 57 | 63% | 1-1 | 5.54 | 1.31 |
| 2008-04-07 | Joe Saunders | L | 27 | L 6-4 | vs CLE | 2 | 35 | - | 8.0 | 4 | 1 | 1 | 1 | 2 | 5 | 111 | 44 | 67 | 60% | 1-0 | 0.56 | 0.69 |
| 2008-04-08 | Ervin Santana | R | 25 | W 3-4 | vs CLE | 2 | 84 | - | 6.0 | 6 | 2 | 2 | 0 | 3 | 5 | 107 | 44 | 63 | 59% | 1-0 | 3.00 | 1.25 |
| 2008-04-09 | Dustin Moseley | R | 26 | L 9-5 | vs CLE | 2 | 12 | W | 6.0 | 9 | 4 | 4 | 2 | 1 | 5 | 95 | 32 | 63 | 66% | 1-1 | 7.36 | 1.64 |
| 2008-04-11 | Jered Weaver | R | 26 | L 5-8 | @ SEA | 3 | 50 | L | 5.2 | 4 | 5 | 5 | 2 | 4 | 3 | 100 | 42 | 58 | 58% | 1-2 | 3.79 | 1.11 |
| 2008-04-12 | Jon Garland | R | 29 | L 3-8 | @ SEA | 3 | 226 | L | 5.0 | 12 | 6 | 3 | 1 | 1 | 0 | 98 | 39 | 59 | 60% | 1-2 | 5.50 | 1.67 |
| 2008-04-13 | Joe Saunders | L | 27 | W 10-5 | @ SEA | 3 | 36 | W | 5.1 | 6 | 2 | 2 | 0 | 3 | 1 | 93 | 46 | 47 | 51% | 2-0 | 1.29 | 0.95 |
| 2008-04-14 | Ervin Santana | R | 25 | W 7-4 | @ TEX | 3 | 85 | W | 7.0 | 7 | 3 | 3 | 1 | 1 | 6 | 111 | 40 | 71 | 64% | 2-0 | 3.32 | 1.21 |
| 2008-04-15 | Dustin Moseley | R | 26 | W 7-4 | @ TEX | 3 | 13 | - | 4.0 | 7 | 4 | 4 | 0 | 5 | 1 | 88 | 40 | 48 | 55% | 1-1 | 7.80 | 2.00 |
| 2008-04-16 | Jered Weaver | R | 26 | W 2-3 | vs KCA | 4 | 51 | L | 6.0 | 10 | 3 | 2 | 0 | 1 | 1 | 96 | 37 | 59 | 61% | 1-3 | 3.60 | 1.28 |
| 2008-04-17 | Jon Garland | R | 29 | L 5-3 | vs KCA | 4 | 227 | W | 6.1 | 7 | 2 | 2 | 0 | 3 | 1 | 92 | 35 | 57 | 62% | 2-2 | 4.88 | 1.67 |
| 2008-04-18 | Joe Saunders | L | 27 | L 5-4 | vs SEA | 4 | 37 | W | 8.0 | 6 | 4 | 4 | 2 | 0 | 2 | 100 | 36 | 64 | 64% | 3-0 | 2.17 | 0.90 |
| 2008-04-19 | Ervin Santana | R | 25 | L 4-1 | vs SEA | 4 | 86 | W | 8.0 | 3 | 1 | 1 | 1 | 0 | 8 | 109 | 37 | 72 | 66% | 3-0 | 2.67 | 0.96 |
| 2008-04-20 | Dustin Moseley | R | 26 | W 2-4 | vs SEA | 4 | 14 | L | 4.2 | 8 | 4 | 4 | 1 | 2 | 3 | 88 | 36 | 52 | 59% | 1-2 | 7.65 | 2.00 |
| 2008-04-22 | Jered Weaver | R | 26 | L 6-7 | @ BOS | 5 | 52 | - | 5.0 | 10 | 5 | 5 | 2 | 0 | 4 | 104 | 33 | 71 | 68% | 1-3 | 4.50 | 1.40 |
| 2008-04-23 | Jon Garland | R | 29 | W 6-4 | @ BOS | 5 | 228 | W | 6.0 | 8 | 4 | 4 | 1 | 2 | 1 | 82 | 35 | 47 | 57% | 3-2 | 5.10 | 1.67 |
| 2008-04-24 | Joe Saunders | L | 27 | W 7-5 | @ BOS | 5 | 38 | W | 6.0 | 7 | 3 | 3 | 0 | 3 | 3 | 102 | 46 | 56 | 55% | 4-0 | 2.57 | 1.03 |
| 2008-04-25 | Ervin Santana | R | 25 | W 4-3 | @ DET | 5 | 87 | W | 6.1 | 6 | 3 | 3 | 1 | 2 | 4 | 111 | 40 | 71 | 64% | 4-0 | 3.00 | 1.03 |
| 2008-04-26 | Dustin Moseley | R | 26 | L 4-6 | @ DET | 5 | 15 | - | 5.0 | 6 | 3 | 3 | 0 | 2 | 5 | 93 | 37 | 56 | 60% | 1-2 | 7.20 | 1.92 |
| 2008-04-27 | Jered Weaver | R | 26 | W 6-2 | @ DET | 6 | 53 | W | 6.1 | 4 | 2 | 2 | 0 | 4 | 5 | 110 | 44 | 66 | 60% | 2-3 | 4.25 | 1.39 |
| 2008-04-28 | Jon Garland | R | 29 | W 2-14 | vs OAK | 6 | 229 | L | 6.0 | 10 | 7 | 7 | 2 | 3 | 5 | 107 | 39 | 68 | 64% | 3-3 | 6.00 | 1.75 |
| 2008-04-29 | Joe Saunders | L | 27 | L 2-0 | vs OAK | 6 | 39 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 5 | 100 | 38 | 62 | 62% | 5-0 | 2.09 | 0.95 |
| 2008-04-30 | Ervin Santana | R | 25 | L 6-1 | vs OAK | 6 | 88 | W | 6.2 | 4 | 1 | 0 | 0 | 1 | 3 | 112 | 45 | 67 | 60% | 5-0 | 2.48 | 0.98 |
| 2008-05-01 | Nick Adenhart | R | 22 | W 8-15 | vs OAK | 1 | 1 | - | 2.0 | 3 | 5 | 5 | 0 | 5 | 0 | 57 | 33 | 24 | 42% | 0-0 | 22.50 | 4.00 |
| 2008-05-02 | Jered Weaver | R | 26 | W 3-4 | vs BAL | 7 | 54 | L | 7.0 | 6 | 4 | 4 | 1 | 2 | 6 | 108 | 35 | 73 | 68% | 2-4 | 4.40 | 1.35 |
| 2008-05-03 | Jon Garland | R | 29 | L 3-1 | vs BAL | 7 | 230 | W | 8.0 | 3 | 1 | 1 | 0 | 1 | 1 | 96 | 35 | 61 | 64% | 4-3 | 5.11 | 1.52 |
| 2008-05-04 | Joe Saunders | L | 27 | L 6-5 | vs BAL | 7 | 40 | W | 5.0 | 12 | 4 | 4 | 1 | 0 | 1 | 85 | 27 | 58 | 68% | 6-0 | 2.63 | 1.10 |
| 2008-05-05 | Ervin Santana | R | 25 | W 4-0 | @ KCA | 7 | 89 | W | 9.0 | 4 | 0 | 0 | 0 | 0 | 9 | 101 | 31 | 70 | 69% | 6-0 | 2.02 | 0.88 |
| 2008-05-06 | Nick Adenhart | R | 22 | W 5-3 | @ KCA | 2 | 2 | - | 4.1 | 6 | 3 | 3 | 0 | 5 | 3 | 88 | 41 | 47 | 53% | 0-0 | 12.00 | 3.17 |
| 2008-05-07 | Jered Weaver | R | 26 | L 4-9 | @ KCA | 8 | 55 | L | 3.1 | 10 | 8 | 8 | 2 | 1 | 1 | 82 | 31 | 51 | 62% | 2-5 | 5.55 | 1.47 |
| 2008-05-09 | Jon Garland | R | 29 | L 0-2 | @ TBA | 8 | 231 | - | 8.0 | 4 | 0 | 0 | 0 | 3 | 2 | 119 | 47 | 72 | 61% | 4-3 | 4.33 | 1.42 |
| 2008-05-10 | Joe Saunders | L | 27 | L 0-2 | @ TBA | 8 | 41 | L | 6.0 | 4 | 1 | 1 | 0 | 4 | 3 | 104 | 42 | 62 | 60% | 6-1 | 2.50 | 1.13 |
| 2008-05-11 | Ervin Santana | R | 25 | L 5-8 | @ TBA | 8 | 90 | - | 5.2 | 9 | 5 | 5 | 0 | 1 | 7 | 120 | 45 | 75 | 63% | 6-0 | 2.62 | 0.96 |
| 2008-05-12 | Nick Adenhart | R | 22 | L 10-7 | vs CHA | 3 | 3 | W | 5.2 | 9 | 4 | 4 | 0 | 3 | 1 | 98 | 41 | 57 | 58% | 1-0 | 9.00 | 2.58 |
| 2008-05-13 | Jered Weaver | R | 26 | L 2-0 | vs CHA | 9 | 56 | - | 7.0 | 1 | 0 | 0 | 0 | 2 | 6 | 108 | 42 | 66 | 61% | 2-5 | 4.83 | 1.33 |
| 2008-05-14 | John Lackey | R | 30 | W 1-6 | vs CHA | 1 | 183 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 4 | 99 | 32 | 67 | 68% | 0-0 | 1.29 | 1.00 |
| 2008-05-15 | Jon Garland | R | 29 | W 3-4 | vs CHA | 9 | 232 | - | 6.0 | 7 | 3 | 3 | 0 | 4 | 1 | 109 | 45 | 64 | 59% | 4-3 | 4.34 | 1.47 |
| 2008-05-16 | Joe Saunders | L | 27 | L 4-2 | vs LAN | 9 | 42 | W | 7.1 | 5 | 2 | 2 | 1 | 2 | 1 | 90 | 35 | 55 | 61% | 7-1 | 2.47 | 1.10 |
| 2008-05-17 | Ervin Santana | R | 25 | W 3-6 | vs LAN | 9 | 91 | L | 6.0 | 5 | 4 | 4 | 1 | 3 | 5 | 109 | 38 | 71 | 65% | 6-1 | 2.95 | 1.00 |
| 2008-05-18 | Jered Weaver | R | 26 | L 10-2 | vs LAN | 10 | 57 | W | 5.1 | 5 | 2 | 2 | 0 | 2 | 7 | 99 | 32 | 67 | 68% | 3-5 | 4.73 | 1.34 |
| 2008-05-20 | John Lackey | R | 30 | W 3-1 | @ TOR | 2 | 184 | W | 7.0 | 7 | 1 | 1 | 1 | 3 | 6 | 109 | 41 | 68 | 62% | 1-0 | 1.29 | 1.21 |
| 2008-05-21 | Jon Garland | R | 29 | W 4-3 | @ TOR | 10 | 233 | W | 6.0 | 8 | 3 | 3 | 0 | 2 | 1 | 101 | 37 | 64 | 63% | 5-3 | 4.36 | 1.48 |
| 2008-05-22 | Ervin Santana | R | 25 | L 3-4 | @ TOR | 10 | 92 | L | 6.0 | 9 | 4 | 4 | 1 | 2 | 7 | 110 | 37 | 73 | 66% | 6-2 | 3.22 | 1.07 |
| 2008-05-23 | Joe Saunders | L | 27 | W 3-1 | @ CHA | 10 | 43 | W | 8.1 | 3 | 1 | 1 | 0 | 3 | 4 | 98 | 40 | 58 | 59% | 8-1 | 2.31 | 1.06 |
| 2008-05-24 | Jered Weaver | R | 26 | W 2-0 | @ CHA | 11 | 58 | W | 8.0 | 3 | 0 | 0 | 0 | 2 | 6 | 104 | 34 | 70 | 67% | 4-5 | 4.16 | 1.25 |
| 2008-05-25 | John Lackey | R | 30 | L 2-3 | @ CHA | 3 | 185 | L | 8.0 | 6 | 3 | 3 | 2 | 1 | 3 | 81 | 25 | 56 | 69% | 1-1 | 2.05 | 1.09 |
| 2008-05-26 | Jon Garland | R | 29 | L 1-0 | vs DET | 11 | 234 | - | 7.1 | 4 | 0 | 0 | 0 | 3 | 5 | 108 | 40 | 68 | 63% | 5-3 | 3.88 | 1.42 |
| 2008-05-27 | Ervin Santana | R | 25 | L 3-2 | vs DET | 11 | 93 | W | 9.0 | 3 | 2 | 2 | 1 | 0 | 7 | 112 | 33 | 79 | 71% | 7-2 | 3.08 | 0.99 |
| 2008-05-28 | Joe Saunders | L | 27 | W 2-6 | vs DET | 11 | 44 | L | 5.0 | 7 | 5 | 5 | 2 | 1 | 5 | 92 | 33 | 59 | 64% | 8-2 | 2.76 | 1.09 |
| 2008-05-30 | Jered Weaver | R | 26 | W 4-10 | vs TOR | 12 | 59 | L | 4.0 | 10 | 6 | 6 | 1 | 0 | 2 | 94 | 21 | 73 | 78% | 4-6 | 4.69 | 1.32 |
| 2008-05-31 | John Lackey | R | 30 | L 3-2 | vs TOR | 4 | 186 | - | 8.0 | 6 | 2 | 1 | 1 | 1 | 7 | 106 | 31 | 75 | 71% | 1-1 | 1.80 | 1.03 |
| 2008-06-01 | Jon Garland | R | 29 | L 4-3 | vs TOR | 12 | 235 | - | 5.0 | 5 | 3 | 3 | 1 | 4 | 3 | 115 | 42 | 73 | 63% | 5-3 | 3.97 | 1.44 |
| 2008-06-02 | Ervin Santana | R | 25 | W 4-2 | @ SEA | 12 | 94 | W | 7.2 | 6 | 2 | 2 | 1 | 1 | 3 | 109 | 35 | 74 | 68% | 8-2 | 3.04 | 0.99 |
| 2008-06-03 | Joe Saunders | L | 27 | W 5-4 | @ SEA | 12 | 45 | W | 7.0 | 6 | 4 | 1 | 1 | 1 | 5 | 108 | 36 | 72 | 67% | 9-2 | 2.63 | 1.09 |
| 2008-06-04 | Jered Weaver | R | 26 | W 5-4 | @ SEA | 13 | 60 | W | 6.0 | 10 | 4 | 4 | 1 | 1 | 3 | 109 | 38 | 71 | 65% | 5-6 | 4.79 | 1.36 |
| 2008-06-06 | John Lackey | R | 30 | W 3-1 | @ OAK | 5 | 187 | W | 7.0 | 4 | 1 | 1 | 1 | 0 | 5 | 100 | 34 | 66 | 66% | 2-1 | 1.70 | 0.95 |
| 2008-06-07 | Jon Garland | R | 29 | W 5-3 | @ OAK | 13 | 236 | W | 7.0 | 5 | 2 | 2 | 1 | 1 | 8 | 91 | 32 | 59 | 65% | 6-3 | 3.86 | 1.39 |
| 2008-06-08 | Ervin Santana | R | 25 | L 3-7 | @ OAK | 13 | 95 | - | 6.1 | 7 | 2 | 2 | 0 | 3 | 9 | 112 | 40 | 72 | 64% | 8-2 | 3.00 | 1.02 |
| 2008-06-09 | Joe Saunders | L | 27 | W 4-13 | vs TBA | 13 | 46 | L | 4.2 | 9 | 8 | 8 | 3 | 2 | 4 | 101 | 40 | 61 | 60% | 9-3 | 3.31 | 1.15 |
| 2008-06-10 | Jered Weaver | R | 26 | L 6-1 | vs TBA | 14 | 61 | W | 8.0 | 4 | 1 | 1 | 1 | 2 | 5 | 110 | 40 | 70 | 64% | 6-6 | 4.45 | 1.31 |
| 2008-06-11 | John Lackey | R | 30 | L 4-2 | vs TBA | 6 | 188 | W | 7.1 | 4 | 2 | 2 | 0 | 2 | 7 | 99 | 38 | 61 | 62% | 3-1 | 1.84 | 0.93 |
| 2008-06-13 | Jon Garland | R | 29 | W 2-5 | vs ATL | 14 | 237 | L | 5.2 | 12 | 5 | 5 | 0 | 1 | 4 | 76 | 26 | 50 | 66% | 6-4 | 4.15 | 1.46 |
| 2008-06-14 | Ervin Santana | R | 25 | W 4-9 | vs ATL | 14 | 96 | L | 5.2 | 9 | 6 | 6 | 2 | 2 | 6 | 96 | 37 | 59 | 61% | 8-3 | 3.41 | 1.08 |
| 2008-06-15 | Joe Saunders | L | 27 | L 2-0 | vs ATL | 14 | 47 | W | 7.1 | 6 | 0 | 0 | 0 | 0 | 3 | 99 | 34 | 65 | 66% | 10-3 | 3.06 | 1.13 |
| 2008-06-16 | Jered Weaver | R | 26 | W 6-9 | vs NYN | 15 | 62 | L | 6.1 | 8 | 6 | 6 | 2 | 1 | 5 | 98 | 31 | 67 | 68% | 6-7 | 4.75 | 1.32 |
| 2008-06-17 | John Lackey | R | 30 | L 6-1 | vs NYN | 7 | 189 | W | 7.2 | 6 | 1 | 1 | 0 | 1 | 7 | 106 | 31 | 75 | 71% | 4-1 | 1.73 | 0.92 |
| 2008-06-18 | Jon Garland | R | 29 | W 4-5 | vs NYN | 15 | 238 | - | 6.0 | 6 | 3 | 2 | 1 | 4 | 3 | 104 | 36 | 68 | 65% | 6-4 | 4.07 | 1.47 |
| 2008-06-20 | Ervin Santana | R | 25 | W 7-1 | @ PHI | 15 | 97 | W | 7.0 | 2 | 1 | 0 | 0 | 2 | 9 | 110 | 35 | 75 | 68% | 9-3 | 3.18 | 1.05 |
| 2008-06-21 | Joe Saunders | L | 27 | W 6-2 | @ PHI | 15 | 48 | W | 7.0 | 5 | 2 | 2 | 1 | 2 | 3 | 93 | 33 | 60 | 65% | 11-3 | 3.03 | 1.12 |
| 2008-06-22 | Jered Weaver | R | 26 | W 3-2 | @ PHI | 16 | 63 | W | 5.1 | 4 | 1 | 1 | 0 | 3 | 6 | 94 | 34 | 60 | 64% | 7-7 | 4.55 | 1.31 |
| 2008-06-23 | John Lackey | R | 30 | W 3-2 | @ WAS | 8 | 190 | W | 8.0 | 6 | 2 | 1 | 1 | 2 | 6 | 97 | 32 | 65 | 67% | 5-1 | 1.65 | 0.93 |
| 2008-06-24 | Jon Garland | R | 29 | W 8-3 | @ WAS | 16 | 239 | W | 7.0 | 6 | 3 | 3 | 2 | 1 | 4 | 105 | 32 | 73 | 70% | 7-4 | 4.06 | 1.44 |
| 2008-06-25 | Ervin Santana | R | 25 | L 4-5 | @ WAS | 16 | 98 | - | 6.0 | 4 | 4 | 4 | 1 | 5 | 8 | 99 | 32 | 67 | 68% | 9-3 | 3.33 | 1.07 |
| 2008-06-27 | Joe Saunders | L | 27 | L 0-6 | @ LAN | 16 | 49 | L | 5.0 | 5 | 3 | 2 | 1 | 4 | 4 | 97 | 42 | 55 | 57% | 11-4 | 3.06 | 1.15 |
| 2008-06-28 | Jered Weaver | R | 26 | L 0-1 | @ LAN | 17 | 64 | L | 6.0 | 0 | 1 | 0 | 0 | 3 | 6 | 98 | 39 | 59 | 60% | 7-8 | 4.28 | 1.26 |
| 2008-06-29 | John Lackey | R | 30 | W 1-0 | @ LAN | 9 | 191 | W | 8.2 | 3 | 0 | 0 | 0 | 2 | 9 | 121 | 43 | 78 | 64% | 6-1 | 1.43 | 0.88 |
| 2008-06-30 | Jon Garland | R | 29 | W 1-6 | vs OAK | 17 | 240 | L | 6.0 | 8 | 4 | 2 | 0 | 1 | 6 | 106 | 40 | 66 | 62% | 7-5 | 4.00 | 1.44 |
| 2008-07-01 | Ervin Santana | R | 25 | L 5-3 | vs OAK | 17 | 99 | - | 7.0 | 8 | 2 | 2 | 0 | 2 | 7 | 115 | 38 | 77 | 67% | 9-3 | 3.29 | 1.10 |
| 2008-07-02 | Joe Saunders | L | 27 | L 7-4 | vs OAK | 17 | 50 | W | 6.1 | 6 | 4 | 2 | 0 | 2 | 5 | 110 | 43 | 67 | 61% | 12-4 | 3.05 | 1.16 |
| 2008-07-04 | Jered Weaver | R | 26 | L 8-2 | vs TOR | 18 | 65 | W | 7.1 | 6 | 2 | 2 | 0 | 1 | 6 | 103 | 33 | 70 | 68% | 8-8 | 4.17 | 1.25 |
| 2008-07-05 | John Lackey | R | 30 | W 5-7 | vs TOR | 10 | 192 | L | 6.0 | 8 | 6 | 5 | 1 | 1 | 7 | 103 | 30 | 73 | 71% | 6-2 | 1.92 | 0.93 |
| 2008-07-06 | Jon Garland | R | 29 | L 7-1 | vs TOR | 18 | 241 | W | 9.0 | 6 | 1 | 1 | 1 | 0 | 3 | 97 | 31 | 66 | 68% | 8-5 | 3.77 | 1.38 |
| 2008-07-07 | Ervin Santana | R | 25 | W 9-6 | @ TEX | 18 | 100 | W | 7.0 | 10 | 6 | 6 | 2 | 2 | 6 | 105 | 32 | 73 | 70% | 10-3 | 3.54 | 1.13 |
| 2008-07-08 | Joe Saunders | L | 27 | L 2-3 | @ TEX | 18 | 51 | L | 8.0 | 6 | 3 | 3 | 1 | 0 | 5 | 109 | 38 | 71 | 65% | 12-5 | 3.08 | 1.13 |
| 2008-07-09 | Jered Weaver | R | 26 | L 4-5 | @ TEX | 19 | 66 | - | 6.0 | 7 | 2 | 1 | 0 | 2 | 5 | 100 | 38 | 62 | 62% | 8-8 | 4.03 | 1.26 |
| 2008-07-10 | John Lackey | R | 30 | W 11-10 | @ TEX | 11 | 193 | - | 5.2 | 15 | 6 | 6 | 2 | 1 | 5 | 103 | 33 | 70 | 68% | 6-2 | 2.48 | 1.08 |
| 2008-07-11 | Jon Garland | R | 29 | L 2-9 | @ OAK | 19 | 242 | L | 2.2 | 10 | 7 | 7 | 0 | 2 | 1 | 84 | 31 | 53 | 63% | 8-6 | 4.20 | 1.45 |
| 2008-07-12 | Ervin Santana | R | 26 | W 4-1 | @ OAK | 19 | 101 | W | 7.0 | 5 | 0 | 0 | 0 | 2 | 10 | 114 | 41 | 73 | 64% | 11-3 | 3.35 | 1.12 |
| 2008-07-13 | Dustin Moseley | R | 27 | W 4-3 | @ OAK | 6 | 16 | - | 5.1 | 4 | 2 | 2 | 0 | 1 | 4 | 81 | 30 | 51 | 63% | 1-3 | 7.15 | 1.76 |
| 2008-07-18 | John Lackey | R | 30 | L 11-3 | vs BOS | 12 | 194 | W | 7.0 | 5 | 3 | 3 | 2 | 2 | 6 | 89 | 31 | 58 | 65% | 7-2 | 2.59 | 1.07 |
| 2008-07-19 | Joe Saunders | L | 27 | L 4-2 | vs BOS | 19 | 52 | - | 6.2 | 6 | 2 | 2 | 1 | 3 | 1 | 111 | 44 | 67 | 60% | 12-5 | 3.05 | 1.14 |
| 2008-07-20 | Jon Garland | R | 29 | L 5-3 | vs BOS | 20 | 243 | - | 6.2 | 6 | 3 | 2 | 0 | 3 | 6 | 116 | 49 | 67 | 58% | 8-6 | 4.11 | 1.44 |
| 2008-07-21 | Ervin Santana | R | 26 | W 2-5 | vs CLE | 20 | 102 | L | 7.0 | 7 | 4 | 3 | 2 | 0 | 8 | 109 | 39 | 70 | 64% | 11-4 | 3.38 | 1.12 |
| 2008-07-22 | Jered Weaver | R | 26 | L 3-2 | vs CLE | 20 | 67 | - | 3.0 | 3 | 2 | 2 | 1 | 2 | 4 | 77 | 34 | 43 | 56% | 8-8 | 4.08 | 1.27 |
| 2008-07-23 | John Lackey | R | 30 | L 14-11 | vs CLE | 13 | 195 | W | 5.0 | 8 | 6 | 6 | 1 | 2 | 5 | 99 | 32 | 67 | 68% | 8-2 | 3.03 | 1.12 |
| 2008-07-25 | Joe Saunders | L | 27 | W 6-5 | @ BAL | 20 | 53 | W | 6.2 | 6 | 4 | 3 | 1 | 2 | 2 | 108 | 41 | 67 | 62% | 13-5 | 3.09 | 1.14 |
| 2008-07-26 | Jon Garland | R | 29 | W 11-6 | @ BAL | 21 | 244 | W | 5.1 | 7 | 5 | 5 | 2 | 2 | 3 | 89 | 34 | 55 | 62% | 9-6 | 4.30 | 1.45 |
| 2008-07-27 | Ervin Santana | R | 26 | L 2-5 | @ BAL | 21 | 103 | L | 5.0 | 7 | 5 | 5 | 0 | 3 | 5 | 100 | 38 | 62 | 62% | 11-5 | 3.57 | 1.15 |
| 2008-07-28 | Jered Weaver | R | 26 | W 7-5 | @ BOS | 21 | 68 | W | 5.2 | 6 | 3 | 3 | 0 | 3 | 4 | 97 | 39 | 58 | 60% | 9-8 | 4.10 | 1.28 |
| 2008-07-29 | John Lackey | R | 30 | W 6-2 | @ BOS | 14 | 196 | W | 9.0 | 2 | 2 | 2 | 1 | 2 | 4 | 120 | 39 | 81 | 68% | 9-2 | 2.94 | 1.06 |
| 2008-07-30 | Joe Saunders | L | 27 | W 9-2 | @ BOS | 21 | 54 | W | 6.0 | 5 | 2 | 2 | 1 | 3 | 2 | 102 | 45 | 57 | 56% | 14-5 | 3.09 | 1.15 |
| 2008-07-31 | Jon Garland | R | 29 | W 12-6 | @ NYA | 22 | 245 | W | 6.0 | 7 | 3 | 3 | 2 | 1 | 3 | 105 | 38 | 67 | 64% | 10-6 | 4.30 | 1.45 |
| 2008-08-01 | Ervin Santana | R | 26 | W 1-0 | @ NYA | 22 | 104 | W | 8.0 | 5 | 0 | 0 | 0 | 2 | 8 | 120 | 48 | 72 | 60% | 12-5 | 3.38 | 1.13 |
| 2008-08-02 | Jered Weaver | R | 26 | L 2-8 | @ NYA | 22 | 69 | L | 5.0 | 8 | 6 | 6 | 4 | 1 | 5 | 98 | 29 | 69 | 70% | 9-9 | 4.36 | 1.30 |
| 2008-08-03 | John Lackey | R | 30 | L 9-14 | @ NYA | 15 | 197 | - | 6.0 | 7 | 4 | 4 | 1 | 4 | 4 | 100 | 39 | 61 | 61% | 9-2 | 3.11 | 1.10 |
| 2008-08-04 | Joe Saunders | L | 27 | L 6-5 | vs BAL | 22 | 55 | - | 6.0 | 6 | 1 | 1 | 0 | 2 | 2 | 97 | 40 | 57 | 59% | 14-5 | 3.02 | 1.16 |
| 2008-08-05 | Jon Garland | R | 29 | W 0-3 | vs BAL | 23 | 246 | L | 7.0 | 9 | 3 | 3 | 1 | 0 | 1 | 107 | 35 | 72 | 67% | 10-7 | 4.28 | 1.44 |
| 2008-08-06 | Ervin Santana | R | 26 | L 9-4 | vs BAL | 23 | 105 | W | 7.0 | 8 | 4 | 4 | 2 | 0 | 7 | 105 | 29 | 76 | 72% | 13-5 | 3.46 | 1.13 |
| 2008-08-08 | Jered Weaver | R | 26 | L 10-5 | vs NYA | 23 | 70 | W | 6.0 | 7 | 5 | 5 | 2 | 2 | 3 | 111 | 41 | 70 | 63% | 10-9 | 4.50 | 1.31 |
| 2008-08-09 | John Lackey | R | 30 | L 11-4 | vs NYA | 16 | 198 | - | 7.0 | 9 | 3 | 3 | 2 | 1 | 5 | 93 | 26 | 67 | 72% | 9-2 | 3.16 | 1.12 |
| 2008-08-10 | Joe Saunders | L | 27 | L 4-3 | vs NYA | 23 | 56 | - | 7.0 | 6 | 3 | 3 | 0 | 3 | 6 | 109 | 39 | 70 | 64% | 14-5 | 3.06 | 1.16 |
| 2008-08-12 | Jon Garland | R | 29 | L 7-3 | vs SEA | 24 | 247 | W | 7.0 | 9 | 3 | 3 | 0 | 1 | 4 | 99 | 36 | 63 | 64% | 11-7 | 4.26 | 1.44 |
| 2008-08-13 | Ervin Santana | R | 26 | W 7-10 | vs SEA | 24 | 106 | - | 6.1 | 7 | 3 | 3 | 1 | 1 | 7 | 110 | 40 | 70 | 64% | 13-5 | 3.48 | 1.13 |
| 2008-08-15 | Jered Weaver | R | 26 | L 2-3 | @ CLE | 24 | 71 | - | 5.1 | 5 | 2 | 2 | 0 | 2 | 6 | 107 | 43 | 64 | 60% | 10-9 | 4.47 | 1.31 |
| 2008-08-16 | John Lackey | R | 30 | W 4-3 | @ CLE | 17 | 199 | W | 6.0 | 6 | 3 | 3 | 2 | 3 | 3 | 106 | 47 | 59 | 56% | 10-2 | 3.23 | 1.14 |
| 2008-08-17 | Joe Saunders | L | 27 | L 3-4 | @ CLE | 24 | 57 | - | 5.0 | 8 | 3 | 3 | 0 | 2 | 2 | 101 | 40 | 61 | 60% | 14-5 | 3.13 | 1.19 |
| 2008-08-18 | Jon Garland | R | 29 | L 4-6 | @ TBA | 25 | 248 | L | 6.0 | 10 | 5 | 4 | 2 | 2 | 3 | 100 | 34 | 66 | 66% | 11-8 | 4.33 | 1.46 |
| 2008-08-19 | Ervin Santana | R | 26 | L 2-4 | @ TBA | 25 | 107 | - | 7.0 | 4 | 1 | 1 | 0 | 2 | 9 | 106 | 40 | 66 | 62% | 13-5 | 3.39 | 1.12 |
| 2008-08-20 | Jered Weaver | R | 26 | W 5-4 | @ TBA | 25 | 72 | - | 6.0 | 5 | 3 | 3 | 0 | 1 | 9 | 119 | 45 | 74 | 62% | 10-9 | 4.47 | 1.30 |
| 2008-08-21 | John Lackey | R | 30 | W 1-2 | vs MIN | 18 | 200 | - | 8.0 | 5 | 1 | 1 | 0 | 2 | 6 | 103 | 43 | 60 | 58% | 10-2 | 3.09 | 1.13 |
| 2008-08-22 | Joe Saunders | L | 27 | W 0-9 | vs MIN | 25 | 58 | L | 5.1 | 9 | 6 | 6 | 1 | 0 | 0 | 87 | 28 | 59 | 68% | 14-6 | 3.37 | 1.21 |
| 2008-08-23 | Jon Garland | R | 29 | L 7-5 | vs MIN | 26 | 249 | - | 4.1 | 6 | 5 | 5 | 1 | 1 | 1 | 89 | 43 | 46 | 52% | 11-8 | 4.50 | 1.47 |
| 2008-08-24 | Ervin Santana | R | 26 | L 5-3 | vs MIN | 26 | 108 | - | 7.0 | 9 | 3 | 3 | 1 | 0 | 10 | 105 | 31 | 74 | 70% | 13-5 | 3.41 | 1.13 |
| 2008-08-25 | Jered Weaver | R | 26 | W 1-2 | vs OAK | 26 | 73 | L | 7.0 | 3 | 2 | 2 | 1 | 2 | 8 | 108 | 41 | 67 | 62% | 10-10 | 4.38 | 1.27 |
| 2008-08-26 | John Lackey | R | 30 | L 5-1 | vs OAK | 19 | 201 | W | 9.0 | 7 | 1 | 1 | 1 | 0 | 5 | 98 | 25 | 73 | 74% | 11-2 | 2.96 | 1.10 |
| 2008-08-27 | Joe Saunders | L | 27 | W 5-6 | vs OAK | 26 | 59 | L | 1.1 | 8 | 6 | 6 | 1 | 1 | 1 | 49 | 20 | 29 | 59% | 14-7 | 3.68 | 1.26 |
| 2008-08-28 | Jon Garland | R | 29 | L 7-5 | vs TEX | 27 | 250 | W | 8.0 | 8 | 5 | 5 | 2 | 1 | 3 | 108 | 40 | 68 | 63% | 12-8 | 4.55 | 1.45 |
| 2008-08-29 | Ervin Santana | R | 26 | L 3-1 | vs TEX | 27 | 109 | W | 8.0 | 5 | 1 | 1 | 0 | 1 | 7 | 108 | 36 | 72 | 67% | 14-5 | 3.31 | 1.11 |
| 2008-08-30 | Jered Weaver | R | 26 | L 4-3 | vs TEX | 27 | 74 | - | 5.0 | 5 | 3 | 3 | 0 | 2 | 6 | 108 | 41 | 67 | 62% | 10-10 | 4.42 | 1.28 |
| 2008-08-31 | John Lackey | R | 30 | W 3-4 | vs TEX | 20 | 202 | L | 5.0 | 9 | 4 | 4 | 2 | 1 | 5 | 102 | 40 | 62 | 61% | 11-3 | 3.11 | 1.13 |
| 2008-09-02 | Joe Saunders | L | 27 | W 5-4 | @ DET | 27 | 60 | - | 6.1 | 8 | 3 | 3 | 0 | 1 | 2 | 103 | 43 | 60 | 58% | 14-7 | 3.68 | 1.26 |
| 2008-09-03 | Jon Garland | R | 29 | L 6-9 | @ DET | 28 | 251 | - | 6.0 | 7 | 5 | 5 | 0 | 3 | 4 | 102 | 42 | 60 | 59% | 12-8 | 4.65 | 1.46 |
| 2008-09-04 | Ervin Santana | R | 26 | W 7-1 | @ DET | 28 | 110 | W | 7.1 | 6 | 1 | 1 | 1 | 1 | 8 | 114 | 38 | 76 | 67% | 15-5 | 3.23 | 1.11 |
| 2008-09-05 | Dustin Moseley | R | 27 | L 2-10 | @ CHA | 7 | 17 | L | 1.1 | 6 | 4 | 4 | 1 | 2 | 0 | 38 | 15 | 23 | 61% | 1-4 | 7.97 | 1.94 |
| 2008-09-06 | John Lackey | R | 30 | L 6-7 | @ CHA | 21 | 203 | - | 7.0 | 9 | 5 | 5 | 2 | 2 | 4 | 100 | 38 | 62 | 62% | 11-3 | 3.26 | 1.15 |
| 2008-09-07 | Joe Saunders | L | 27 | W 3-2 | @ CHA | 28 | 61 | W | 7.1 | 4 | 2 | 2 | 2 | 1 | 4 | 91 | 33 | 58 | 64% | 15-7 | 3.64 | 1.24 |
| 2008-09-08 | Jon Garland | R | 29 | L 12-1 | vs NYA | 29 | 252 | W | 7.0 | 6 | 1 | 1 | 0 | 2 | 4 | 94 | 38 | 56 | 60% | 13-8 | 4.52 | 1.45 |
| 2008-09-09 | Ervin Santana | R | 26 | W 1-7 | vs NYA | 29 | 111 | L | 6.1 | 8 | 6 | 5 | 2 | 1 | 6 | 103 | 33 | 70 | 68% | 15-6 | 3.36 | 1.12 |
| 2008-09-10 | Dustin Moseley | R | 27 | L 4-2 | vs NYA | 8 | 18 | W | 5.0 | 3 | 2 | 2 | 0 | 3 | 6 | 78 | 35 | 43 | 55% | 2-4 | 7.43 | 1.85 |
| 2008-09-11 | Jered Weaver | R | 26 | L 7-4 | vs SEA | 28 | 75 | W | 6.0 | 3 | 0 | 0 | 0 | 3 | 3 | 96 | 33 | 63 | 66% | 11-10 | 4.25 | 1.27 |
| 2008-09-12 | Joe Saunders | L | 27 | L 5-3 | vs SEA | 29 | 62 | - | 7.0 | 8 | 3 | 3 | 0 | 1 | 5 | 98 | 36 | 62 | 63% | 15-7 | 3.65 | 1.24 |
| 2008-09-13 | Jon Garland | R | 29 | L 5-2 | vs SEA | 30 | 253 | W | 6.0 | 6 | 2 | 2 | 0 | 3 | 1 | 101 | 35 | 66 | 65% | 14-8 | 4.48 | 1.45 |
| 2008-09-14 | Ervin Santana | R | 26 | L 4-3 | vs SEA | 30 | 112 | - | 7.0 | 6 | 2 | 2 | 0 | 1 | 3 | 89 | 32 | 57 | 64% | 15-6 | 3.34 | 1.12 |
| 2008-09-16 | John Lackey | R | 30 | L 1-8 | @ OAK | 22 | 204 | L | 5.1 | 9 | 4 | 4 | 1 | 1 | 4 | 113 | 49 | 64 | 57% | 11-4 | 3.37 | 1.17 |
| 2008-09-17 | Jered Weaver | R | 26 | L 2-3 | @ OAK | 29 | 76 | - | 6.0 | 6 | 1 | 1 | 0 | 3 | 8 | 105 | 40 | 65 | 62% | 11-10 | 4.16 | 1.27 |
| 2008-09-18 | Joe Saunders | L | 27 | W 6-4 | @ OAK | 30 | 63 | W | 7.0 | 6 | 0 | 0 | 0 | 3 | 4 | 88 | 35 | 53 | 60% | 16-7 | 3.52 | 1.24 |
| 2008-09-19 | Jon Garland | R | 29 | W 15-13 | @ TEX | 31 | 254 | - | 2.1 | 10 | 9 | 8 | 1 | 0 | 4 | 85 | 28 | 57 | 67% | 14-8 | 4.78 | 1.48 |
| 2008-09-20 | Dustin Moseley | R | 27 | W 7-3 | @ TEX | 9 | 19 | - | 5.0 | 8 | 3 | 3 | 0 | 1 | 3 | 73 | 24 | 49 | 67% | 2-4 | 7.20 | 1.84 |
| 2008-09-21 | John Lackey | R | 30 | W 7-3 | @ TEX | 23 | 205 | W | 6.0 | 2 | 0 | 0 | 0 | 3 | 12 | 111 | 42 | 69 | 62% | 12-4 | 3.24 | 1.16 |
| 2008-09-22 | Ervin Santana | R | 26 | W 2-1 | @ SEA | 31 | 113 | W | 8.0 | 5 | 1 | 1 | 0 | 0 | 9 | 101 | 32 | 69 | 68% | 16-6 | 3.25 | 1.10 |
| 2008-09-23 | Jered Weaver | R | 26 | L 6-9 | @ SEA | 30 | 77 | - | 5.2 | 9 | 6 | 6 | 0 | 0 | 8 | 98 | 31 | 67 | 68% | 11-10 | 4.32 | 1.28 |
| 2008-09-24 | Jon Garland | R | 29 | W 6-5 | @ SEA | 32 | 255 | - | 5.0 | 11 | 5 | 5 | 0 | 1 | 2 | 99 | 35 | 64 | 65% | 14-8 | 4.89 | 1.50 |
| 2008-09-25 | Dustin Moseley | R | 27 | W 6-4 | @ SEA | 10 | 20 | - | 5.0 | 6 | 2 | 2 | 0 | 1 | 3 | 86 | 31 | 55 | 64% | 2-4 | 6.84 | 1.80 |
| 2008-09-26 | John Lackey | R | 30 | W 1-12 | vs TEX | 24 | 206 | L | 2.2 | 12 | 10 | 10 | 2 | 2 | 1 | 71 | 26 | 45 | 63% | 12-5 | 3.75 | 1.23 |
| 2008-09-27 | Ervin Santana | R | 26 | W 4-8 | vs TEX | 32 | 114 | L | 5.2 | 10 | 8 | 8 | 2 | 1 | 5 | 105 | 33 | 72 | 69% | 16-7 | 3.49 | 1.12 |
| 2008-09-28 | Joe Saunders | L | 27 | L 7-0 | vs TEX | 31 | 64 | W | 6.0 | 2 | 0 | 0 | 0 | 0 | 9 | 93 | 39 | 54 | 58% | 17-7 | 3.41 | 1.21 |