| 2007-04-02 | @ CHA | 1 | W 12-5 | 1-0 | 1 | 38,088 | CC Sabathia | Jose Contreras | CC Sabathia | Jose Contreras | | 12 | 5 | 7 |
| 2007-04-04 | @ CHA | 2 | W 8-7 | 2-0 | 1 | 26,337 | Jake Westbrook | Jon Garland | Aaron Fultz | Matt Thornton | Joe Borowski | 20 | 12 | 8 |
| 2007-04-05 | @ CHA | 3 | L 3-4 | 2-1 | 2 | 24,141 | Jeremy Sowers | Mark Buehrle | Bobby Jenks | Roberto Hernandez | | 23 | 16 | 7 |
| 2007-04-10 | vs ANA | 4 | W 7-6 | 3-1 | 1 | 19,031 | CC Sabathia | Ervin Santana | CC Sabathia | Ervin Santana | Joe Borowski | 30 | 22 | 8 |
| 2007-04-11 | vs ANA | 5 | L 1-4 | 3-2 | 3 | 16,375 | Jake Westbrook | Joe Saunders | Joe Saunders | Jake Westbrook | Francisco Rodriguez | 31 | 26 | 5 |
| 2007-04-12 | vs ANA | 6 | W 4-2 | 4-2 | 1 | 17,090 | Jeremy Sowers | Dustin Moseley | Aaron Fultz | Scot Shields | Joe Borowski | 35 | 28 | 7 |
| 2007-04-13 | vs CHA | 7 | L 4-6 | 4-3 | 3 | 16,789 | Fausto Carmona | Javier Vazquez | Javier Vazquez | Fausto Carmona | Bobby Jenks | 39 | 34 | 5 |
| 2007-04-14 | vs CHA | 8 | W 4-0 | 5-3 | 3 | 18,082 | Paul Byrd | John Danks | Paul Byrd | John Danks | Joe Borowski | 43 | 34 | 9 |
| 2007-04-15 | vs CHA | 9 | W 2-1 | 6-3 | 1 | 14,887 | CC Sabathia | Jose Contreras | CC Sabathia | Jose Contreras | Joe Borowski | 45 | 35 | 10 |
| 2007-04-17 | @ NYA | 10 | L 3-10 | 6-4 | 3 | 38,438 | Jake Westbrook | Chase Wright | Chase Wright | Jake Westbrook | | 48 | 45 | 3 |
| 2007-04-18 | @ NYA | 11 | L 2-9 | 6-5 | 3 | 41,379 | Jeremy Sowers | Kei Igawa | Kei Igawa | Jeremy Sowers | | 50 | 54 | -4 |
| 2007-04-19 | @ NYA | 12 | L 6-8 | 6-6 | 4 | 40,872 | Fausto Carmona | Darrell Rasner | Sean Henn | Joe Borowski | | 56 | 62 | -6 |
| 2007-04-20 | @ TBA | 13 | W 4-3 | 7-6 | 3 | 13,391 | CC Sabathia | Edwin Jackson | Roberto Hernandez | Juan Salas | Joe Borowski | 60 | 65 | -5 |
| 2007-04-21 | @ TBA | 14 | L 5-6 | 7-7 | 4 | 22,805 | Paul Byrd | Jae Weong Seo | Jae Weong Seo | Paul Byrd | Alberto Reyes | 65 | 71 | -6 |
| 2007-04-22 | @ TBA | 15 | W 6-4 | 8-7 | 3 | 18,131 | Jake Westbrook | James Shields | Tom Mastny | Brian Stokes | Joe Borowski | 71 | 75 | -4 |
| 2007-04-23 | @ MIN | 16 | W 7-3 | 9-7 | 3 | 16,076 | Jeremy Sowers | Carlos Silva | Roberto Hernandez | Jesse Crain | | 78 | 78 | 0 |
| 2007-04-24 | @ MIN | 17 | W 5-3 | 10-7 | 1 | 20,849 | Fausto Carmona | Johan Santana | Fausto Carmona | Johan Santana | Joe Borowski | 83 | 81 | 2 |
| 2007-04-25 | vs TEX | 18 | W 8-7 | 11-7 | 1 | 13,843 | CC Sabathia | Vicente Padilla | Fernando Cabrera | Willie Eyre | | 91 | 88 | 3 |
| 2007-04-26 | vs TEX | 19 | W 9-4 | 12-7 | 1 | 14,066 | Paul Byrd | Kameron Loe | Paul Byrd | Kameron Loe | | 100 | 92 | 8 |
| 2007-04-27 | vs BAL | 20 | W 5-4 | 13-7 | 1 | 20,484 | Jake Westbrook | Steve Trachsel | Jake Westbrook | Steve Trachsel | Joe Borowski | 105 | 96 | 9 |
| 2007-04-28 | vs BAL | 21 | L 4-7 | 13-8 | 1 | 25,065 | Jeremy Sowers | Erik Bedard | Jamie Walker | Fernando Cabrera | Chris Ray | 109 | 103 | 6 |
| 2007-04-29 | vs BAL | 22 | W 6-1 | 14-8 | 1 | 25,402 | Fausto Carmona | Jaret Wright | Fausto Carmona | Jaret Wright | | 115 | 104 | 11 |
| 2007-05-01 | vs TOR | 23 | W 12-4 | 15-8 | 1 | 13,389 | CC Sabathia | A.J. Burnett | CC Sabathia | A.J. Burnett | | 127 | 108 | 19 |
| 2007-05-02 | vs TOR | 24 | W 7-6 | 16-8 | 1 | 14,163 | Jake Westbrook | Victor Zambrano | Tom Mastny | Shaun Marcum | | 134 | 114 | 20 |
| 2007-05-03 | vs TOR | 25 | W 6-5 | 17-8 | 1 | 16,284 | Cliff Lee | Dustin McGowan | Aaron Fultz | Jason Frasor | Joe Borowski | 140 | 119 | 21 |
| 2007-05-04 | @ BAL | 26 | L 2-3 | 17-9 | 1 | 28,575 | Paul Byrd | Erik Bedard | Chris Ray | Tom Mastny | | 142 | 122 | 20 |
| 2007-05-05 | @ BAL | 27 | L 2-8 | 17-10 | 1 | 25,752 | Jeremy Sowers | Daniel Cabrera | Daniel Cabrera | Jeremy Sowers | | 144 | 130 | 14 |
| 2007-05-06 | @ BAL | 28 | W 9-6 | 18-10 | 1 | 37,464 | CC Sabathia | Brian Burres | CC Sabathia | Brian Burres | Joe Borowski | 153 | 136 | 17 |
| 2007-05-07 | @ BAL | 29 | W 10-1 | 19-10 | 1 | 17,944 | Fausto Carmona | Steve Trachsel | Fausto Carmona | Chad Bradford | | 163 | 137 | 26 |
| 2007-05-08 | @ ANA | 30 | W 5-1 | 20-10 | 1 | 41,731 | Cliff Lee | Ervin Santana | Cliff Lee | Ervin Santana | | 168 | 138 | 30 |
| 2007-05-09 | @ ANA | 31 | L 2-3 | 20-11 | 1 | 40,007 | Paul Byrd | Jered Weaver | Dustin Moseley | Fernando Cabrera | Francisco Rodriguez | 170 | 141 | 29 |
| 2007-05-10 | @ ANA | 32 | L 0-8 | 20-12 | 2 | 33,698 | Jeremy Sowers | Kelvim Escobar | Kelvim Escobar | Jeremy Sowers | | 170 | 149 | 21 |
| 2007-05-11 | @ OAK | 33 | L 2-8 | 20-13 | 2 | 20,393 | CC Sabathia | Joe Blanton | Joe Blanton | CC Sabathia | | 172 | 157 | 15 |
| 2007-05-12 | @ OAK | 34 | W 6-3 | 21-13 | 2 | 22,705 | Fausto Carmona | Dallas Braden | Fausto Carmona | Dallas Braden | Joe Borowski | 178 | 160 | 18 |
| 2007-05-13 | @ OAK | 35 | L 7-10 | 21-14 | 2 | 24,692 | Cliff Lee | Chad Gaudin | Jay Witasick | Joe Borowski | | 185 | 170 | 15 |
| 2007-05-15 | vs MIN | 36 | W 15-7 | 22-14 | 2 | 23,325 | Paul Byrd | Ramon Ortiz | Paul Byrd | Ramon Ortiz | | 200 | 177 | 23 |
| 2007-05-16 | vs MIN | 37 | W 7-1 | 23-14 | 2 | 17,678 | CC Sabathia | Carlos Silva | CC Sabathia | Carlos Silva | | 207 | 178 | 29 |
| 2007-05-17 | vs MIN | 38 | W 2-0 | 24-14 | 1 | 28,609 | Fausto Carmona | Johan Santana | Fausto Carmona | Johan Santana | | 209 | 178 | 31 |
| 2007-05-18 | vs CIN | 39 | W 9-4 | 25-14 | 1 | 34,230 | Cliff Lee | Kyle Lohse | Cliff Lee | Kyle Lohse | | 218 | 182 | 36 |
| 2007-05-19 | vs CIN | 40 | L 5-10 | 25-15 | 2 | 35,262 | Jeremy Sowers | Matt Belisle | Matt Belisle | Jeremy Sowers | David Weathers | 223 | 192 | 31 |
| 2007-05-20 | vs CIN | 41 | W 5-3 | 26-15 | 2 | 32,524 | Paul Byrd | Aaron Harang | Paul Byrd | Aaron Harang | Joe Borowski | 228 | 195 | 33 |
| 2007-05-21 | vs SEA | 42 | W 5-2 | 27-15 | 1 | 38,645 | CC Sabathia | Cha-Seung Baek | Tom Mastny | Cha-Seung Baek | Joe Borowski | 233 | 197 | 36 |
| 2007-05-22 | @ KCA | 43 | L 3-4 | 27-16 | 1 | 19,776 | Fausto Carmona | Odalis Perez | Zack Greinke | Tom Mastny | Joakim Soria | 236 | 201 | 35 |
| 2007-05-23 | @ KCA | 44 | L 7-11 | 27-17 | 2 | 11,506 | Cliff Lee | Scott Elarton | Brandon Duckworth | Cliff Lee | | 243 | 212 | 31 |
| 2007-05-24 | @ KCA | 45 | W 10-3 | 28-17 | 2 | 11,681 | Jeremy Sowers | Jorge de la Rosa | Jeremy Sowers | Jorge de la Rosa | | 253 | 215 | 38 |
| 2007-05-25 | @ DET | 46 | W 7-4 | 29-17 | 1 | 40,074 | Paul Byrd | Nate Robertson | Paul Byrd | Nate Robertson | Joe Borowski | 260 | 219 | 41 |
| 2007-05-26 | @ DET | 47 | W 6-3 | 30-17 | 1 | 40,375 | CC Sabathia | Justin Verlander | CC Sabathia | Jason Grilli | Joe Borowski | 266 | 222 | 44 |
| 2007-05-27 | @ DET | 48 | W 5-3 | 31-17 | 1 | 40,723 | Fausto Carmona | Mike Maroth | Fausto Carmona | Mike Maroth | Joe Borowski | 271 | 225 | 46 |
| 2007-05-28 | @ BOS | 49 | L 3-5 | 31-18 | 1 | 36,910 | Cliff Lee | Curt Schilling | Curt Schilling | Cliff Lee | Jonathan Papelbon | 274 | 230 | 44 |
| 2007-05-29 | @ BOS | 50 | L 2-4 | 31-19 | 1 | 37,076 | Jeremy Sowers | Josh Beckett | Josh Beckett | Jeremy Sowers | Hideki Okajima | 276 | 234 | 42 |
| 2007-05-30 | @ BOS | 51 | W 8-4 | 32-19 | 1 | 37,091 | Paul Byrd | Daisuke Matsuzaka | Paul Byrd | Daisuke Matsuzaka | | 284 | 238 | 46 |
| 2007-05-31 | vs DET | 52 | W 11-5 | 33-19 | 1 | 30,038 | CC Sabathia | Justin Verlander | CC Sabathia | Justin Verlander | | 295 | 243 | 52 |
| 2007-06-01 | vs DET | 53 | W 12-11 | 34-19 | 1 | 41,365 | Fausto Carmona | Mike Maroth | Roberto Hernandez | Todd Jones | | 307 | 254 | 53 |
| 2007-06-02 | vs DET | 54 | L 5-9 | 34-20 | 1 | 38,254 | Cliff Lee | Chad Durbin | Chad Durbin | Cliff Lee | | 312 | 263 | 49 |
| 2007-06-03 | vs DET | 55 | L 2-9 | 34-21 | 1 | 30,268 | Jeremy Sowers | Jeremy Bonderman | Jeremy Bonderman | Jeremy Sowers | | 314 | 272 | 42 |
| 2007-06-05 | vs KCA | 56 | W 1-0 | 35-21 | 1 | 14,036 | CC Sabathia | Jorge de la Rosa | CC Sabathia | Jorge de la Rosa | | 315 | 272 | 43 |
| 2007-06-06 | vs KCA | 57 | L 3-4 | 35-22 | 1 | 17,632 | Paul Byrd | Brian Bannister | Brian Bannister | Paul Byrd | Octavio Dotel | 318 | 276 | 42 |
| 2007-06-07 | vs KCA | 58 | W 8-3 | 36-22 | 1 | 19,315 | Fausto Carmona | Odalis Perez | Fausto Carmona | Odalis Perez | | 326 | 279 | 47 |
| 2007-06-08 | @ CIN | 59 | L 3-4 | 36-23 | 1 | 38,696 | Cliff Lee | Homer Bailey | Homer Bailey | Cliff Lee | David Weathers | 329 | 283 | 46 |
| 2007-06-09 | @ CIN | 60 | W 8-6 | 37-23 | 1 | 37,935 | Jeremy Sowers | Matt Belisle | Tom Mastny | Victor Santos | Joe Borowski | 337 | 289 | 48 |
| 2007-06-10 | @ CIN | 61 | L 0-1 | 37-24 | 1 | 30,842 | CC Sabathia | Aaron Harang | Marcus McBeth | Aaron Fultz | | 337 | 290 | 47 |
| 2007-06-11 | vs SEA | 62 | L 7-8 | 37-25 | 1 | 22,325 | Paul Byrd | Cha-Seung Baek | Brandon Morrow | Joe Borowski | | 344 | 298 | 46 |
| 2007-06-12 | @ FLO | 63 | L 0-3 | 37-26 | 2 | 15,144 | Fausto Carmona | Scott Olsen | Scott Olsen | Fausto Carmona | Kevin Gregg | 344 | 301 | 43 |
| 2007-06-13 | @ FLO | 64 | W 7-3 | 38-26 | 1 | 13,805 | Cliff Lee | Byung-Hyun Kim | Cliff Lee | Byung-Hyun Kim | | 351 | 304 | 47 |
| 2007-06-14 | @ FLO | 65 | W 3-2 | 39-26 | 1 | 23,811 | Jason Stanford | Dontrelle Willis | Jason Stanford | Dontrelle Willis | Joe Borowski | 354 | 306 | 48 |
| 2007-06-15 | vs ATL | 66 | L 4-5 | 39-27 | 1 | 34,848 | CC Sabathia | Buddy Carlyle | Rafael Soriano | CC Sabathia | Bob Wickman | 358 | 311 | 47 |
| 2007-06-16 | vs ATL | 67 | L 2-6 | 39-28 | 1 | 35,153 | Paul Byrd | John Smoltz | John Smoltz | Paul Byrd | | 360 | 317 | 43 |
| 2007-06-17 | vs ATL | 68 | W 5-2 | 40-28 | 1 | 33,429 | Fausto Carmona | Kyle Davies | Fausto Carmona | Kyle Davies | Joe Borowski | 365 | 319 | 46 |
| 2007-06-18 | vs PHI | 69 | W 10-1 | 41-28 | 1 | 18,710 | Cliff Lee | Cole Hamels | Cliff Lee | Cole Hamels | | 375 | 320 | 55 |
| 2007-06-19 | vs PHI | 70 | L 6-9 | 41-29 | 2 | 17,371 | Jason Stanford | Kyle Kendrick | Kyle Kendrick | Jason Stanford | | 381 | 329 | 52 |
| 2007-06-20 | vs PHI | 71 | W 10-6 | 42-29 | 2 | 24,278 | CC Sabathia | Jon Lieber | CC Sabathia | Jon Lieber | | 391 | 335 | 56 |
| 2007-06-22 | @ WAS | 72 | L 1-4 | 42-30 | 2 | 24,534 | Fausto Carmona | Micah Bowie | Saul Rivera | Fausto Carmona | Chad Cordero | 392 | 339 | 53 |
| 2007-06-23 | @ WAS | 73 | W 4-3 | 43-30 | 2 | 32,539 | Paul Byrd | Matt Chico | Tom Mastny | Chad Cordero | Joe Borowski | 396 | 342 | 54 |
| 2007-06-24 | @ WAS | 74 | L 1-3 | 43-31 | 2 | 26,413 | Jake Westbrook | Jason Simontacchi | Jason Simontacchi | Jake Westbrook | Chad Cordero | 397 | 345 | 52 |
| 2007-06-25 | vs OAK | 75 | W 5-2 | 44-31 | 2 | 17,737 | CC Sabathia | Chad Gaudin | CC Sabathia | Chad Gaudin | | 402 | 347 | 55 |
| 2007-06-26 | vs OAK | 76 | W 8-5 | 45-31 | 2 | 18,494 | Cliff Lee | Dan Haren | Rafael Betancourt | Alan Embree | | 410 | 352 | 58 |
| 2007-06-27 | vs OAK | 77 | L 7-13 | 45-32 | 2 | 18,614 | Fausto Carmona | Lenny DiNardo | Lenny DiNardo | Fausto Carmona | | 417 | 365 | 52 |
| 2007-06-28 | vs OAK | 78 | W 4-3 | 46-32 | 2 | 22,921 | Paul Byrd | Joe Blanton | Paul Byrd | Ron Flores | Joe Borowski | 421 | 368 | 53 |
| 2007-06-29 | vs TBA | 79 | W 2-1 | 47-32 | 2 | 34,557 | Jake Westbrook | Edwin Jackson | Joe Borowski | Shawn Camp | | 423 | 369 | 54 |
| 2007-06-30 | vs TBA | 80 | W 8-6 | 48-32 | 1 | 36,726 | CC Sabathia | J.P. Howell | CC Sabathia | J.P. Howell | Joe Borowski | 431 | 375 | 56 |
| 2007-07-01 | vs TBA | 81 | W 3-2 | 49-32 | 1 | 30,410 | Cliff Lee | James Shields | Cliff Lee | James Shields | Joe Borowski | 434 | 377 | 57 |
| 2007-07-02 | vs TBA | 82 | W 10-2 | 50-32 | 1 | 34,372 | Fausto Carmona | Andy Sonnanstine | Fausto Carmona | Andy Sonnanstine | | 444 | 379 | 65 |
| 2007-07-03 | @ DET | 83 | W 5-4 | 51-32 | 1 | 40,741 | Paul Byrd | Nate Robertson | Tom Mastny | Jose Capellan | Joe Borowski | 449 | 383 | 66 |
| 2007-07-04 | @ DET | 84 | L 4-6 | 51-33 | 1 | 40,782 | Jake Westbrook | Kenny Rogers | Kenny Rogers | Jake Westbrook | Todd Jones | 453 | 389 | 64 |
| 2007-07-05 | @ DET | 85 | L 3-12 | 51-34 | 1 | 40,923 | CC Sabathia | Justin Verlander | Justin Verlander | CC Sabathia | | 456 | 401 | 55 |
| 2007-07-06 | @ TOR | 86 | L 6-8 | 51-35 | 2 | 28,526 | Cliff Lee | Roy Halladay | Roy Halladay | Cliff Lee | Jeremy Accardo | 462 | 409 | 53 |
| 2007-07-07 | @ TOR | 87 | W 9-4 | 52-35 | 2 | 25,744 | Fausto Carmona | Shaun Marcum | Fausto Carmona | Shaun Marcum | | 471 | 413 | 58 |
| 2007-07-08 | @ TOR | 88 | L 0-1 | 52-36 | 2 | 28,239 | Paul Byrd | Josh Towers | Jeremy Accardo | Paul Byrd | | 471 | 414 | 57 |
| 2007-07-13 | vs KCA | 89 | W 5-4 | 53-36 | 2 | 32,624 | Jake Westbrook | Odalis Perez | Joe Borowski | Zack Greinke | | 476 | 418 | 58 |
| 2007-07-14 | vs KCA | 90 | L 5-6 | 53-37 | 2 | 31,599 | CC Sabathia | Gil Meche | Gil Meche | CC Sabathia | Octavio Dotel | 481 | 424 | 57 |
| 2007-07-15 | vs KCA | 91 | W 5-3 | 54-37 | 2 | 29,657 | Fausto Carmona | Jorge de la Rosa | Fausto Carmona | Jorge de la Rosa | Joe Borowski | 486 | 427 | 59 |
| 2007-07-16 | vs CHA | 92 | L 10-11 | 54-38 | 2 | 21,460 | Cliff Lee | John Danks | John Danks | Cliff Lee | Bobby Jenks | 496 | 438 | 58 |
| 2007-07-17 | vs CHA | 93 | W 6-5 | 55-38 | 2 | 21,321 | Paul Byrd | Jon Garland | Rafael Betancourt | Dewon Day | | 502 | 443 | 59 |
| 2007-07-18 | vs CHA | 94 | L 1-5 | 55-39 | 2 | 29,822 | Jake Westbrook | Mark Buehrle | Mark Buehrle | Jake Westbrook | | 503 | 448 | 55 |
| 2007-07-19 | @ TEX | 95 | W 7-5 | 56-39 | 2 | 28,108 | CC Sabathia | Kameron Loe | CC Sabathia | Kameron Loe | Joe Borowski | 510 | 453 | 57 |
| 2007-07-20 | @ TEX | 96 | W 3-2 | 57-39 | 2 | 32,103 | Fausto Carmona | Brandon McCarthy | Fausto Carmona | Brandon McCarthy | Joe Borowski | 513 | 455 | 58 |
| 2007-07-21 | @ TEX | 97 | L 5-8 | 57-40 | 2 | 44,554 | Cliff Lee | Jamey Wright | Ron Mahay | Cliff Lee | | 518 | 463 | 55 |
| 2007-07-22 | @ TEX | 98 | W 8-3 | 58-40 | 2 | 27,227 | Paul Byrd | Rob Tejeda | Paul Byrd | Rob Tejeda | | 526 | 466 | 60 |
| 2007-07-23 | vs BOS | 99 | L 2-6 | 58-41 | 2 | 32,439 | Jake Westbrook | Jon Lester | Jon Lester | Jake Westbrook | Manny Delcarmen | 528 | 472 | 56 |
| 2007-07-24 | vs BOS | 100 | L 0-1 | 58-42 | 2 | 39,339 | CC Sabathia | Daisuke Matsuzaka | Daisuke Matsuzaka | CC Sabathia | Jonathan Papelbon | 528 | 473 | 55 |
| 2007-07-25 | vs BOS | 101 | W 1-0 | 59-42 | 2 | 29,614 | Fausto Carmona | Josh Beckett | Fausto Carmona | Josh Beckett | Joe Borowski | 529 | 473 | 56 |
| 2007-07-26 | vs BOS | 102 | L 9-14 | 59-43 | 2 | 34,286 | Cliff Lee | Kason Gabbard | Julian Tavarez | Cliff Lee | | 538 | 487 | 51 |
| 2007-07-27 | vs MIN | 103 | W 10-4 | 60-43 | 2 | 37,292 | Paul Byrd | Boof Bonser | Paul Byrd | Boof Bonser | | 548 | 491 | 57 |
| 2007-07-28 | vs MIN | 104 | L 2-3 | 60-44 | 2 | 41,203 | Jake Westbrook | Johan Santana | Pat Neshek | Joe Borowski | Joe Nathan | 550 | 494 | 56 |
| 2007-07-29 | vs MIN | 105 | L 1-4 | 60-45 | 2 | 37,102 | CC Sabathia | Matt Garza | Dennys Reyes | CC Sabathia | Joe Nathan | 551 | 498 | 53 |
| 2007-07-31 | vs TEX | 106 | L 1-3 | 60-46 | 2 | 21,811 | Fausto Carmona | Brandon McCarthy | Brandon McCarthy | Fausto Carmona | C.J. Wilson | 552 | 501 | 51 |
| 2007-08-01 | vs TEX | 107 | L 6-9 | 60-47 | 2 | 25,721 | Paul Byrd | John Rheinecker | Joaquin Benoit | Jensen Lewis | C.J. Wilson | 558 | 510 | 48 |
| 2007-08-02 | vs TEX | 108 | W 5-0 | 61-47 | 2 | 27,250 | Jake Westbrook | Kason Gabbard | Jake Westbrook | Kason Gabbard | | 563 | 510 | 53 |
| 2007-08-03 | @ MIN | 109 | W 5-2 | 62-47 | 2 | 31,664 | CC Sabathia | Johan Santana | CC Sabathia | Johan Santana | Joe Borowski | 568 | 512 | 56 |
| 2007-08-04 | @ MIN | 110 | L 2-3 | 62-48 | 2 | 33,663 | Aaron Laffey | Matt Garza | Ramon Ortiz | Aaron Laffey | Joe Nathan | 570 | 515 | 55 |
| 2007-08-05 | @ MIN | 111 | L 0-1 | 62-49 | 2 | 38,334 | Fausto Carmona | Scott Baker | Scott Baker | Fausto Carmona | Joe Nathan | 570 | 516 | 54 |
| 2007-08-06 | @ MIN | 112 | W 4-0 | 63-49 | 2 | 28,314 | Paul Byrd | Carlos Silva | Paul Byrd | Carlos Silva | | 574 | 516 | 58 |
| 2007-08-07 | @ CHA | 113 | W 2-1 | 64-49 | 2 | 32,315 | Jake Westbrook | John Danks | Jake Westbrook | John Danks | Joe Borowski | 576 | 517 | 59 |
| 2007-08-08 | @ CHA | 114 | L 4-6 | 64-50 | 2 | 33,147 | CC Sabathia | Jon Garland | Jose Contreras | Aaron Fultz | | 580 | 523 | 57 |
| 2007-08-09 | @ CHA | 115 | W 7-5 | 65-50 | 1 | 36,399 | Aaron Laffey | Mark Buehrle | Aaron Laffey | Mark Buehrle | Joe Borowski | 587 | 528 | 59 |
| 2007-08-10 | vs NYA | 116 | L 1-6 | 65-51 | 1 | 41,675 | Fausto Carmona | Phil Hughes | Phil Hughes | Fausto Carmona | | 588 | 534 | 54 |
| 2007-08-11 | vs NYA | 117 | L 2-11 | 65-52 | 2 | 41,977 | Paul Byrd | Mike Mussina | Mike Mussina | Paul Byrd | | 590 | 545 | 45 |
| 2007-08-12 | vs NYA | 118 | L 3-5 | 65-53 | 2 | 41,612 | Jake Westbrook | Andy Pettitte | Andy Pettitte | Jake Westbrook | Mariano Rivera | 593 | 550 | 43 |
| 2007-08-14 | vs DET | 119 | L 2-6 | 65-54 | 2 | 37,570 | CC Sabathia | Jeremy Bonderman | Fernando Rodney | Joe Borowski | | 595 | 556 | 39 |
| 2007-08-15 | vs DET | 120 | W 5-2 | 66-54 | 2 | 39,250 | Fausto Carmona | Jair Jurrjens | Fausto Carmona | Jair Jurrjens | Joe Borowski | 600 | 558 | 42 |
| 2007-08-17 | @ TBA | 121 | W 2-1 | 67-54 | 2 | 15,343 | Paul Byrd | Edwin Jackson | Paul Byrd | Edwin Jackson | Joe Borowski | 602 | 559 | 43 |
| 2007-08-18 | @ TBA | 122 | W 8-1 | 68-54 | 1 | 24,397 | Jake Westbrook | Jason Hammel | Jake Westbrook | Jason Hammel | | 610 | 560 | 50 |
| 2007-08-19 | @ TBA | 123 | L 3-4 | 68-55 | 1 | 22,328 | CC Sabathia | James Shields | Scott Dohmann | Rafael Perez | | 613 | 564 | 49 |
| 2007-08-21 | @ DET | 124 | L 1-2 | 68-56 | 2 | 42,868 | Fausto Carmona | Jair Jurrjens | Jair Jurrjens | Fausto Carmona | Todd Jones | 614 | 566 | 48 |
| 2007-08-22 | @ DET | 125 | W 11-8 | 69-56 | 1 | 40,914 | Paul Byrd | Justin Verlander | Paul Byrd | Justin Verlander | Joe Borowski | 625 | 574 | 51 |
| 2007-08-23 | @ DET | 126 | W 3-1 | 70-56 | 1 | 40,946 | Jake Westbrook | Nate Robertson | Rafael Perez | Joel Zumaya | Joe Borowski | 628 | 575 | 53 |
| 2007-08-24 | @ KCA | 127 | L 1-2 | 70-57 | 1 | 25,640 | CC Sabathia | Zack Greinke | John Bale | CC Sabathia | Joakim Soria | 629 | 577 | 52 |
| 2007-08-25 | @ KCA | 128 | W 9-4 | 71-57 | 1 | 23,167 | Aaron Laffey | Kyle Davies | Aaron Laffey | Kyle Davies | | 638 | 581 | 57 |
| 2007-08-26 | @ KCA | 129 | W 5-3 | 72-57 | 1 | 18,268 | Fausto Carmona | Gil Meche | Rafael Betancourt | Joel Peralta | Joe Borowski | 643 | 584 | 59 |
| 2007-08-27 | vs MIN | 130 | W 8-3 | 73-57 | 1 | 23,178 | Paul Byrd | Carlos Silva | Paul Byrd | Carlos Silva | | 651 | 587 | 64 |
| 2007-08-28 | vs MIN | 131 | W 6-5 | 74-57 | 1 | 24,784 | Jake Westbrook | Boof Bonser | Jake Westbrook | Boof Bonser | Joe Borowski | 657 | 592 | 65 |
| 2007-08-29 | vs MIN | 132 | W 4-3 | 75-57 | 1 | 27,303 | CC Sabathia | Johan Santana | CC Sabathia | Johan Santana | Joe Borowski | 661 | 595 | 66 |
| 2007-08-30 | vs SEA | 133 | W 6-5 | 76-57 | 1 | 25,949 | Aaron Laffey | Horacio Ramirez | Joe Borowski | Eric O'Flaherty | | 667 | 600 | 67 |
| 2007-08-31 | vs CHA | 134 | W 8-5 | 77-57 | 1 | 38,325 | Fausto Carmona | Mark Buehrle | Aaron Fultz | Mike MacDougal | Rafael Betancourt | 675 | 605 | 70 |
| 2007-09-01 | vs CHA | 135 | W 7-0 | 78-57 | 1 | 41,131 | Paul Byrd | Javier Vazquez | Paul Byrd | Javier Vazquez | | 682 | 605 | 77 |
| 2007-09-02 | vs CHA | 136 | L 0-8 | 78-58 | 1 | 37,718 | Jake Westbrook | Jose Contreras | Jose Contreras | Jake Westbrook | | 682 | 613 | 69 |
| 2007-09-03 | @ MIN | 137 | W 5-0 | 79-58 | 1 | 24,105 | CC Sabathia | Johan Santana | CC Sabathia | Johan Santana | | 687 | 613 | 74 |
| 2007-09-04 | @ MIN | 138 | W 7-5 | 80-58 | 1 | 16,218 | Aaron Laffey | Kevin Slowey | Rafael Betancourt | Julio DePaula | Joe Borowski | 694 | 618 | 76 |
| 2007-09-05 | @ MIN | 139 | W 6-2 | 81-58 | 1 | 13,977 | Fausto Carmona | Scott Baker | Fausto Carmona | Scott Baker | Rafael Perez | 700 | 620 | 80 |
| 2007-09-06 | @ ANA | 140 | L 3-10 | 81-59 | 1 | 41,720 | Paul Byrd | Kelvim Escobar | Kelvim Escobar | Paul Byrd | | 703 | 630 | 73 |
| 2007-09-07 | @ ANA | 141 | L 2-3 | 81-60 | 1 | 40,020 | Jake Westbrook | John Lackey | Scot Shields | Rafael Betancourt | | 705 | 633 | 72 |
| 2007-09-08 | @ ANA | 142 | W 6-1 | 82-60 | 1 | 43,544 | CC Sabathia | Ervin Santana | CC Sabathia | Ervin Santana | | 711 | 634 | 77 |
| 2007-09-09 | @ ANA | 143 | W 6-2 | 83-60 | 1 | 40,037 | Aaron Laffey | Jered Weaver | Aaron Laffey | Jered Weaver | | 717 | 636 | 81 |
| 2007-09-10 | @ CHA | 144 | W 6-2 | 84-60 | 1 | 30,126 | Fausto Carmona | Gavin Floyd | Fausto Carmona | Gavin Floyd | | 723 | 638 | 85 |
| 2007-09-11 | @ CHA | 145 | W 8-3 | 85-60 | 1 | 31,939 | Paul Byrd | John Danks | Paul Byrd | Lance Broadway | | 731 | 641 | 90 |
| 2007-09-12 | @ CHA | 146 | L 4-7 | 85-61 | 1 | 23,537 | Jake Westbrook | Javier Vazquez | Javier Vazquez | Jake Westbrook | | 735 | 648 | 87 |
| 2007-09-14 | vs KCA | 147 | W 5-4 | 86-61 | 1 | 35,230 | CC Sabathia | Brian Bannister | Joe Borowski | David Riske | | 740 | 652 | 88 |
| 2007-09-15 | vs KCA | 148 | W 6-0 | 87-61 | 1 | 32,113 | Fausto Carmona | Zack Greinke | Fausto Carmona | Zack Greinke | | 746 | 652 | 94 |
| 2007-09-16 | vs KCA | 149 | L 3-4 | 87-62 | 1 | 30,112 | Aaron Laffey | Billy Buckner | Billy Buckner | Aaron Laffey | Joakim Soria | 749 | 656 | 93 |
| 2007-09-17 | vs DET | 150 | W 6-5 | 88-62 | 1 | 28,825 | Paul Byrd | Kenny Rogers | Rafael Betancourt | Zach Miner | | 755 | 661 | 94 |
| 2007-09-18 | vs DET | 151 | W 7-4 | 89-62 | 1 | 41,103 | Jake Westbrook | Justin Verlander | Jensen Lewis | Justin Verlander | Joe Borowski | 762 | 665 | 97 |
| 2007-09-19 | vs DET | 152 | W 4-2 | 90-62 | 1 | 32,511 | CC Sabathia | Nate Robertson | CC Sabathia | Nate Robertson | Joe Borowski | 766 | 667 | 99 |
| 2007-09-21 | vs OAK | 153 | W 4-3 | 91-62 | 1 | 36,016 | Fausto Carmona | Joe Blanton | Fausto Carmona | Joe Blanton | Joe Borowski | 770 | 670 | 100 |
| 2007-09-22 | vs OAK | 154 | L 3-9 | 91-63 | 1 | 40,663 | Paul Byrd | Dan Haren | Dan Haren | Paul Byrd | | 773 | 679 | 94 |
| 2007-09-23 | vs OAK | 155 | W 6-2 | 92-63 | 1 | 40,250 | Jake Westbrook | Dallas Braden | Jake Westbrook | Dallas Braden | Rafael Betancourt | 779 | 681 | 98 |
| 2007-09-25 | @ SEA | 156 | W 4-3 | 93-63 | 1 | 22,200 | Aaron Laffey | Felix Hernandez | Tom Mastny | Brandon Morrow | Rafael Betancourt | 783 | 684 | 99 |
| 2007-09-26 | @ SEA | 157 | W 12-4 | 93-64 | 1 | 0 | Fausto Carmona | Ryan Feierabend | Fausto Carmona | Ryan Feierabend | | 795 | 688 | 107 |
| 2007-09-26 | @ SEA | 158 | L 2-3 | 93-64 | 1 | 26,801 | Jeremy Sowers | Jarrod Washburn | J.J. Putz | Aaron Fultz | | 797 | 691 | 106 |
| 2007-09-27 | @ SEA | 159 | L 2-4 | 93-65 | 1 | 21,285 | Paul Byrd | Cha-Seung Baek | Cha-Seung Baek | Paul Byrd | George Sherrill | 799 | 695 | 104 |
| 2007-09-28 | @ KCA | 160 | W 5-3 | 94-65 | 1 | 29,846 | CC Sabathia | Kyle Davies | CC Sabathia | Kyle Davies | Joe Borowski | 804 | 698 | 106 |
| 2007-09-29 | @ KCA | 161 | L 3-4 | 94-66 | 1 | 24,274 | Jake Westbrook | Gil Meche | Joakim Soria | Rafael Perez | | 807 | 702 | 105 |
| 2007-09-30 | @ KCA | 162 | W 4-2 | 95-66 | 1 | 19,104 | Aaron Laffey | Luke Hochevar | Aaron Laffey | Luke Hochevar | Joe Borowski | 811 | 704 | 107 |