| 2007-04-02 | vs TEX | 1 | W 4-1 | 1-0 | 2 | 43,906 | John Lackey | Kevin Millwood | John Lackey | Kevin Millwood | Francisco Rodriguez | 4 | 1 | 3 |
| 2007-04-03 | vs TEX | 2 | W 8-3 | 2-0 | 2 | 42,463 | Kelvim Escobar | Vicente Padilla | Kelvim Escobar | Vicente Padilla | | 12 | 4 | 8 |
| 2007-04-04 | vs TEX | 3 | W 5-3 | 3-0 | 1 | 35,701 | Ervin Santana | Brandon McCarthy | Ervin Santana | Brandon McCarthy | Francisco Rodriguez | 17 | 7 | 10 |
| 2007-04-05 | vs OAK | 4 | L 3-4 | 3-1 | 1 | 39,234 | Joe Saunders | Chad Gaudin | Justin Duchscherer | Francisco Rodriguez | Huston Street | 20 | 11 | 9 |
| 2007-04-06 | vs OAK | 5 | W 5-2 | 4-1 | 1 | 43,534 | Dustin Moseley | Joe Kennedy | Dustin Moseley | Joe Kennedy | Francisco Rodriguez | 25 | 13 | 12 |
| 2007-04-07 | vs OAK | 6 | W 2-1 | 5-1 | 1 | 44,007 | John Lackey | Dan Haren | John Lackey | Dan Haren | Scot Shields | 27 | 14 | 13 |
| 2007-04-08 | vs OAK | 7 | L 1-2 | 5-2 | 1 | 37,783 | Kelvim Escobar | Joe Blanton | Joe Blanton | Kelvim Escobar | Huston Street | 28 | 16 | 12 |
| 2007-04-10 | @ CLE | 8 | L 6-7 | 5-3 | 1 | 19,031 | Ervin Santana | CC Sabathia | CC Sabathia | Ervin Santana | Joe Borowski | 34 | 23 | 11 |
| 2007-04-11 | @ CLE | 9 | W 4-1 | 6-3 | 1 | 16,375 | Joe Saunders | Jake Westbrook | Joe Saunders | Jake Westbrook | Francisco Rodriguez | 38 | 24 | 14 |
| 2007-04-12 | @ CLE | 10 | L 2-4 | 6-4 | 2 | 17,090 | Dustin Moseley | Jeremy Sowers | Aaron Fultz | Scot Shields | Joe Borowski | 40 | 28 | 12 |
| 2007-04-13 | @ BOS | 11 | L 1-10 | 6-5 | 1 | 35,946 | John Lackey | Tim Wakefield | Tim Wakefield | John Lackey | | 41 | 38 | 3 |
| 2007-04-14 | @ BOS | 12 | L 0-8 | 6-6 | 2 | 36,300 | Hector Carrasco | Curt Schilling | Curt Schilling | Hector Carrasco | | 41 | 46 | -5 |
| 2007-04-16 | @ BOS | 13 | L 2-7 | 6-7 | 3 | 35,424 | Ervin Santana | Josh Beckett | Josh Beckett | Ervin Santana | | 43 | 53 | -10 |
| 2007-04-17 | @ OAK | 14 | L 1-4 | 6-8 | 4 | 20,174 | Jered Weaver | Chad Gaudin | Chad Gaudin | Jered Weaver | Huston Street | 44 | 57 | -13 |
| 2007-04-18 | @ OAK | 15 | L 0-3 | 6-9 | 4 | 17,322 | John Lackey | Dan Haren | Dan Haren | John Lackey | Huston Street | 44 | 60 | -16 |
| 2007-04-20 | vs SEA | 16 | W 8-4 | 7-9 | 2 | 43,359 | Joe Saunders | Miguel Batista | Joe Saunders | Miguel Batista | Francisco Rodriguez | 52 | 64 | -12 |
| 2007-04-21 | vs SEA | 17 | W 7-6 | 8-9 | 2 | 43,752 | Bartolo Colon | Horacio Ramirez | Bartolo Colon | Horacio Ramirez | Francisco Rodriguez | 59 | 70 | -11 |
| 2007-04-22 | vs SEA | 18 | W 6-1 | 9-9 | 2 | 43,628 | Ervin Santana | Jeff Weaver | Ervin Santana | Jeff Weaver | | 65 | 71 | -6 |
| 2007-04-23 | vs DET | 19 | L 5-9 | 9-10 | 2 | 40,563 | Jered Weaver | Mike Maroth | Jason Grilli | Jered Weaver | | 70 | 80 | -10 |
| 2007-04-24 | vs DET | 20 | W 9-8 | 10-10 | 2 | 36,055 | Kelvim Escobar | Jeremy Bonderman | Dustin Moseley | Todd Jones | | 79 | 88 | -9 |
| 2007-04-25 | vs TBA | 21 | W 9-1 | 11-10 | 2 | 36,850 | John Lackey | Edwin Jackson | John Lackey | Edwin Jackson | | 88 | 89 | -1 |
| 2007-04-26 | vs TBA | 22 | W 11-3 | 12-10 | 1 | 35,597 | Bartolo Colon | Jae Weong Seo | Bartolo Colon | Jae Weong Seo | | 99 | 92 | 7 |
| 2007-04-27 | @ CHA | 23 | L 3-7 | 12-11 | 1 | 30,193 | Ervin Santana | Jose Contreras | Jose Contreras | Ervin Santana | | 102 | 99 | 3 |
| 2007-04-28 | @ CHA | 24 | W 3-0 | 13-11 | 1 | 38,208 | Jered Weaver | Jon Garland | Jered Weaver | Jon Garland | Francisco Rodriguez | 105 | 99 | 6 |
| 2007-04-29 | @ CHA | 25 | W 5-2 | 14-11 | 1 | 38,513 | Kelvim Escobar | Mark Buehrle | Kelvim Escobar | Mark Buehrle | Francisco Rodriguez | 110 | 101 | 9 |
| 2007-04-30 | @ KCA | 26 | W 3-1 | 15-11 | 1 | 10,866 | John Lackey | Odalis Perez | John Lackey | Odalis Perez | Francisco Rodriguez | 113 | 102 | 11 |
| 2007-05-01 | @ KCA | 27 | W 7-5 | 16-11 | 1 | 11,225 | Bartolo Colon | Zack Greinke | Bartolo Colon | Zack Greinke | Francisco Rodriguez | 120 | 107 | 13 |
| 2007-05-02 | @ KCA | 28 | L 1-3 | 16-12 | 1 | 9,697 | Ervin Santana | Jorge de la Rosa | Jorge de la Rosa | Ervin Santana | Joakim Soria | 121 | 110 | 11 |
| 2007-05-03 | @ KCA | 29 | L 2-5 | 16-13 | 1 | 12,683 | Jered Weaver | Gil Meche | Gil Meche | Jered Weaver | Joakim Soria | 123 | 115 | 8 |
| 2007-05-04 | vs CHA | 30 | W 5-1 | 17-13 | 1 | 44,126 | Kelvim Escobar | Jose Contreras | Kelvim Escobar | Jose Contreras | Scot Shields | 128 | 116 | 12 |
| 2007-05-05 | vs CHA | 31 | L 3-6 | 17-14 | 1 | 42,574 | John Lackey | Jon Garland | Jon Garland | John Lackey | Bobby Jenks | 131 | 122 | 9 |
| 2007-05-06 | vs CHA | 32 | L 3-4 | 17-15 | 1 | 42,017 | Bartolo Colon | Mark Buehrle | Matt Thornton | Francisco Rodriguez | Bobby Jenks | 134 | 126 | 8 |
| 2007-05-08 | vs CLE | 33 | L 1-5 | 17-16 | 2 | 41,731 | Ervin Santana | Cliff Lee | Cliff Lee | Ervin Santana | | 135 | 131 | 4 |
| 2007-05-09 | vs CLE | 34 | W 3-2 | 18-16 | 1 | 40,007 | Jered Weaver | Paul Byrd | Dustin Moseley | Fernando Cabrera | Francisco Rodriguez | 138 | 133 | 5 |
| 2007-05-10 | vs CLE | 35 | W 8-0 | 19-16 | 1 | 33,698 | Kelvim Escobar | Jeremy Sowers | Kelvim Escobar | Jeremy Sowers | | 146 | 133 | 13 |
| 2007-05-11 | @ TEX | 36 | W 6-3 | 20-16 | 1 | 30,782 | John Lackey | Vicente Padilla | John Lackey | Vicente Padilla | | 152 | 136 | 16 |
| 2007-05-12 | @ TEX | 37 | W 6-3 | 21-16 | 1 | 36,474 | Bartolo Colon | Kameron Loe | Bartolo Colon | Kameron Loe | Francisco Rodriguez | 158 | 139 | 19 |
| 2007-05-13 | @ TEX | 38 | L 6-7 | 21-17 | 1 | 24,847 | Ervin Santana | Mike Wood | Eric Gagne | Scot Shields | | 164 | 146 | 18 |
| 2007-05-14 | @ TEX | 39 | W 7-2 | 22-17 | 1 | 23,421 | Jered Weaver | Kevin Millwood | Jered Weaver | Kevin Millwood | | 171 | 148 | 23 |
| 2007-05-15 | @ SEA | 40 | L 3-11 | 22-18 | 1 | 21,769 | Kelvim Escobar | Felix Hernandez | Sean White | Kelvim Escobar | | 174 | 159 | 15 |
| 2007-05-16 | @ SEA | 41 | W 5-0 | 23-18 | 1 | 22,331 | John Lackey | Cha-Seung Baek | John Lackey | Cha-Seung Baek | | 179 | 159 | 20 |
| 2007-05-17 | @ SEA | 42 | W 7-3 | 24-18 | 1 | 20,488 | Bartolo Colon | Jarrod Washburn | Bartolo Colon | Jarrod Washburn | | 186 | 162 | 24 |
| 2007-05-18 | vs LAN | 43 | W 9-1 | 25-18 | 1 | 44,342 | Ervin Santana | Brad Penny | Ervin Santana | Brad Penny | | 195 | 163 | 32 |
| 2007-05-19 | vs LAN | 44 | W 6-2 | 26-18 | 1 | 44,380 | Jered Weaver | Mark Hendrickson | Jered Weaver | Mark Hendrickson | | 201 | 165 | 36 |
| 2007-05-20 | vs LAN | 45 | W 4-1 | 27-18 | 1 | 44,301 | Kelvim Escobar | Derek Lowe | Kelvim Escobar | Derek Lowe | Francisco Rodriguez | 205 | 166 | 39 |
| 2007-05-22 | @ DET | 46 | W 6-3 | 28-18 | 1 | 28,678 | John Lackey | Mike Maroth | John Lackey | Mike Maroth | Francisco Rodriguez | 211 | 169 | 42 |
| 2007-05-23 | @ DET | 47 | L 7-8 | 28-19 | 1 | 28,105 | Bartolo Colon | Chad Durbin | Chad Durbin | Bartolo Colon | Todd Jones | 218 | 177 | 41 |
| 2007-05-24 | @ DET | 48 | L 0-12 | 28-20 | 1 | 36,048 | Ervin Santana | Jeremy Bonderman | Jeremy Bonderman | Ervin Santana | | 218 | 189 | 29 |
| 2007-05-25 | @ NYA | 49 | W 10-6 | 29-20 | 1 | 50,363 | Jered Weaver | Tyler Clippard | Jered Weaver | Tyler Clippard | | 228 | 195 | 33 |
| 2007-05-26 | @ NYA | 50 | W 3-1 | 30-20 | 1 | 52,536 | Kelvim Escobar | Chien-Ming Wang | Kelvim Escobar | Chien-Ming Wang | Francisco Rodriguez | 231 | 196 | 35 |
| 2007-05-27 | @ NYA | 51 | W 4-3 | 31-20 | 1 | 53,508 | John Lackey | Mike Mussina | John Lackey | Scott Proctor | Francisco Rodriguez | 235 | 199 | 36 |
| 2007-05-28 | vs SEA | 52 | L 5-12 | 31-21 | 1 | 42,352 | Bartolo Colon | Miguel Batista | Miguel Batista | Bartolo Colon | | 240 | 211 | 29 |
| 2007-05-29 | vs SEA | 53 | W 4-1 | 32-21 | 1 | 38,174 | Ervin Santana | Ryan Feierabend | Ervin Santana | Ryan Feierabend | Francisco Rodriguez | 244 | 212 | 32 |
| 2007-05-30 | vs SEA | 54 | W 8-6 | 33-21 | 1 | 39,288 | Jered Weaver | Felix Hernandez | Dustin Moseley | Felix Hernandez | Francisco Rodriguez | 252 | 218 | 34 |
| 2007-05-31 | vs BAL | 55 | L 2-6 | 33-22 | 1 | 42,266 | Kelvim Escobar | Brian Burres | Brian Burres | Kelvim Escobar | | 254 | 224 | 30 |
| 2007-06-01 | vs BAL | 56 | W 3-2 | 34-22 | 1 | 43,012 | John Lackey | Daniel Cabrera | John Lackey | Daniel Cabrera | Francisco Rodriguez | 257 | 226 | 31 |
| 2007-06-02 | vs BAL | 57 | W 7-4 | 35-22 | 1 | 42,190 | Joe Saunders | Steve Trachsel | Joe Saunders | Steve Trachsel | | 264 | 230 | 34 |
| 2007-06-03 | vs BAL | 58 | W 4-3 | 36-22 | 1 | 41,026 | Ervin Santana | Jeremy Guthrie | Chris Bootcheck | Chris Ray | | 268 | 233 | 35 |
| 2007-06-04 | vs MIN | 59 | W 16-3 | 37-22 | 1 | 37,380 | Jered Weaver | Boof Bonser | Jered Weaver | Boof Bonser | | 284 | 236 | 48 |
| 2007-06-05 | vs MIN | 60 | W 5-1 | 38-22 | 1 | 42,001 | Kelvim Escobar | Scott Baker | Kelvim Escobar | Scott Baker | | 289 | 237 | 52 |
| 2007-06-06 | vs MIN | 61 | L 5-8 | 38-23 | 1 | 36,453 | John Lackey | Kevin Slowey | Kevin Slowey | John Lackey | Joe Nathan | 294 | 245 | 49 |
| 2007-06-08 | @ SLN | 62 | W 10-6 | 39-23 | 1 | 44,156 | Bartolo Colon | Kip Wells | Hector Carrasco | Tyler Johnson | | 304 | 251 | 53 |
| 2007-06-09 | @ SLN | 63 | W 9-3 | 40-23 | 1 | 45,392 | Ervin Santana | Braden Looper | Ervin Santana | Braden Looper | | 313 | 254 | 59 |
| 2007-06-10 | @ SLN | 64 | L 6-9 | 40-24 | 1 | 43,612 | Jered Weaver | Todd Wellemeyer | Todd Wellemeyer | Chris Bootcheck | | 319 | 263 | 56 |
| 2007-06-12 | @ CIN | 65 | L 3-5 | 40-25 | 1 | 23,153 | Kelvim Escobar | Bronson Arroyo | Jon Coutlangus | Dustin Moseley | David Weathers | 322 | 268 | 54 |
| 2007-06-13 | @ CIN | 66 | W 6-3 | 41-25 | 1 | 29,655 | John Lackey | Kyle Lohse | John Lackey | Kyle Lohse | Francisco Rodriguez | 328 | 271 | 57 |
| 2007-06-14 | @ CIN | 67 | W 9-7 | 42-25 | 1 | 32,860 | Bartolo Colon | Homer Bailey | Bartolo Colon | Gary Majewski | Francisco Rodriguez | 337 | 278 | 59 |
| 2007-06-15 | @ LAN | 68 | L 1-2 | 42-26 | 1 | 56,000 | Ervin Santana | Derek Lowe | Derek Lowe | Ervin Santana | Takashi Saito | 338 | 280 | 58 |
| 2007-06-16 | @ LAN | 69 | W 3-0 | 43-26 | 1 | 56,000 | Jered Weaver | Jason Schmidt | Jered Weaver | Jason Schmidt | Francisco Rodriguez | 341 | 280 | 61 |
| 2007-06-17 | @ LAN | 70 | W 10-4 | 44-26 | 1 | 56,000 | Kelvim Escobar | Randy Wolf | Kelvim Escobar | Randy Wolf | | 351 | 284 | 67 |
| 2007-06-18 | vs HOU | 71 | W 10-9 | 45-26 | 1 | 42,232 | John Lackey | Chris Sampson | Francisco Rodriguez | Dave Borkowski | | 361 | 293 | 68 |
| 2007-06-19 | vs HOU | 72 | L 5-9 | 45-27 | 1 | 42,156 | Bartolo Colon | Jason Jennings | Jason Jennings | Bartolo Colon | | 366 | 302 | 64 |
| 2007-06-20 | vs HOU | 73 | W 8-4 | 46-27 | 1 | 40,761 | Ervin Santana | Wandy Rodriguez | Hector Carrasco | Dave Borkowski | | 374 | 306 | 68 |
| 2007-06-22 | vs PIT | 74 | W 5-4 | 47-27 | 1 | 43,545 | Joe Saunders | Zach Duke | Scot Shields | Jonah Bayliss | | 379 | 310 | 69 |
| 2007-06-23 | vs PIT | 75 | W 10-1 | 48-27 | 1 | 44,010 | Kelvim Escobar | Ian Snell | Kelvim Escobar | Ian Snell | | 389 | 311 | 78 |
| 2007-06-24 | vs PIT | 76 | W 4-3 | 49-27 | 1 | 42,346 | Bartolo Colon | Tom Gorzelanny | Chris Bootcheck | Matt Capps | | 393 | 314 | 79 |
| 2007-06-25 | vs KCA | 77 | L 3-5 | 49-28 | 1 | 43,895 | John Lackey | John Thomson | John Thomson | John Lackey | Octavio Dotel | 396 | 319 | 77 |
| 2007-06-26 | vs KCA | 78 | L 4-12 | 49-29 | 1 | 44,002 | Ervin Santana | Gil Meche | Gil Meche | Ervin Santana | | 400 | 331 | 69 |
| 2007-06-27 | vs KCA | 79 | L 0-1 | 49-30 | 1 | 41,269 | Jered Weaver | Jorge de la Rosa | Jorge de la Rosa | Jered Weaver | Octavio Dotel | 400 | 332 | 68 |
| 2007-06-29 | @ BAL | 80 | W 9-7 | 50-30 | 1 | 36,689 | Kelvim Escobar | Steve Trachsel | Scot Shields | Chris Ray | Francisco Rodriguez | 409 | 339 | 70 |
| 2007-06-30 | @ BAL | 81 | L 3-6 | 50-31 | 1 | 26,235 | Bartolo Colon | Brian Burres | Brian Burres | Bartolo Colon | Paul Shuey | 412 | 345 | 67 |
| 2007-07-01 | @ BAL | 82 | W 4-3 | 51-31 | 1 | 25,058 | John Lackey | Jeremy Guthrie | John Lackey | Jeremy Guthrie | Francisco Rodriguez | 416 | 348 | 68 |
| 2007-07-03 | @ TEX | 83 | L 3-8 | 51-32 | 1 | 24,871 | Ervin Santana | Kevin Millwood | Kevin Millwood | Ervin Santana | | 419 | 356 | 63 |
| 2007-07-04 | @ TEX | 84 | L 2-4 | 51-33 | 1 | 46,105 | Jered Weaver | Jamey Wright | Jamey Wright | Jered Weaver | Eric Gagne | 421 | 360 | 61 |
| 2007-07-05 | @ TEX | 85 | W 5-2 | 52-33 | 1 | 22,062 | Kelvim Escobar | Rob Tejeda | Kelvim Escobar | Rob Tejeda | | 426 | 362 | 64 |
| 2007-07-06 | @ NYA | 86 | L 9-14 | 52-34 | 1 | 52,059 | Bartolo Colon | Andy Pettitte | Edwar Ramirez | Chris Bootcheck | | 435 | 376 | 59 |
| 2007-07-07 | @ NYA | 87 | W 2-1 | 53-34 | 1 | 54,497 | John Lackey | Roger Clemens | Francisco Rodriguez | Luis Vizcaino | | 437 | 377 | 60 |
| 2007-07-08 | @ NYA | 88 | L 0-12 | 53-35 | 1 | 53,921 | Ervin Santana | Chien-Ming Wang | Chien-Ming Wang | Ervin Santana | | 437 | 389 | 48 |
| 2007-07-13 | vs TEX | 89 | W 2-1 | 54-35 | 1 | 44,100 | Kelvim Escobar | Kevin Millwood | Francisco Rodriguez | Joaquin Benoit | | 439 | 390 | 49 |
| 2007-07-14 | vs TEX | 90 | W 9-5 | 55-35 | 1 | 44,026 | John Lackey | Kameron Loe | John Lackey | Kameron Loe | | 448 | 395 | 53 |
| 2007-07-15 | vs TEX | 91 | L 4-5 | 55-36 | 1 | 44,068 | Jered Weaver | Brandon McCarthy | C.J. Wilson | Justin Speier | Eric Gagne | 452 | 400 | 52 |
| 2007-07-17 | @ TBA | 92 | L 3-8 | 55-37 | 1 | 9,430 | Ervin Santana | James Shields | James Shields | Ervin Santana | | 455 | 408 | 47 |
| 2007-07-18 | @ TBA | 93 | L 2-7 | 55-38 | 1 | 13,521 | Bartolo Colon | Scott Kazmir | Scott Kazmir | Bartolo Colon | | 457 | 415 | 42 |
| 2007-07-19 | @ TBA | 94 | W 3-0 | 56-38 | 1 | 18,163 | Kelvim Escobar | Andy Sonnanstine | Kelvim Escobar | Andy Sonnanstine | Francisco Rodriguez | 460 | 415 | 45 |
| 2007-07-20 | @ MIN | 95 | L 5-7 | 56-39 | 1 | 35,794 | John Lackey | Carlos Silva | Carlos Silva | John Lackey | Joe Nathan | 465 | 422 | 43 |
| 2007-07-21 | @ MIN | 96 | L 2-5 | 56-40 | 1 | 33,868 | Jered Weaver | Boof Bonser | Pat Neshek | Scot Shields | Joe Nathan | 467 | 427 | 40 |
| 2007-07-22 | @ MIN | 97 | W 7-2 | 57-40 | 1 | 33,217 | Joe Saunders | Matt Garza | Joe Saunders | Matt Garza | | 474 | 429 | 45 |
| 2007-07-23 | vs OAK | 98 | L 6-12 | 57-41 | 1 | 43,847 | Bartolo Colon | Chad Gaudin | Joe Kennedy | Bartolo Colon | | 480 | 441 | 39 |
| 2007-07-24 | vs OAK | 99 | L 3-4 | 57-42 | 1 | 43,784 | Kelvim Escobar | Lenny DiNardo | Lenny DiNardo | Kelvim Escobar | Alan Embree | 483 | 445 | 38 |
| 2007-07-25 | vs OAK | 100 | W 7-6 | 58-42 | 1 | 44,252 | John Lackey | Joe Blanton | Francisco Rodriguez | Joe Kennedy | | 490 | 451 | 39 |
| 2007-07-27 | vs DET | 101 | W 11-6 | 59-42 | 1 | 44,042 | Jered Weaver | Nate Robertson | Jered Weaver | Nate Robertson | | 501 | 457 | 44 |
| 2007-07-28 | vs DET | 102 | W 10-3 | 60-42 | 1 | 43,122 | Joe Saunders | Andrew Miller | Scot Shields | Jason Grilli | | 511 | 460 | 51 |
| 2007-07-29 | vs DET | 103 | W 13-4 | 61-42 | 1 | 44,019 | Dustin Moseley | Jeremy Bonderman | Chris Bootcheck | Jeremy Bonderman | | 524 | 464 | 60 |
| 2007-07-30 | @ SEA | 104 | L 0-2 | 61-43 | 1 | 31,232 | Kelvim Escobar | Miguel Batista | Miguel Batista | Kelvim Escobar | J.J. Putz | 524 | 466 | 58 |
| 2007-07-31 | @ SEA | 105 | W 8-0 | 62-43 | 1 | 28,903 | John Lackey | Jeff Weaver | John Lackey | Jeff Weaver | | 532 | 466 | 66 |
| 2007-08-01 | @ SEA | 106 | L 7-8 | 62-44 | 1 | 34,471 | Jered Weaver | Felix Hernandez | Eric O'Flaherty | Justin Speier | | 539 | 474 | 65 |
| 2007-08-02 | @ OAK | 107 | W 6-4 | 63-44 | 1 | 21,654 | Joe Saunders | Chad Gaudin | Joe Saunders | Chad Gaudin | Francisco Rodriguez | 545 | 478 | 67 |
| 2007-08-03 | @ OAK | 108 | L 4-8 | 63-45 | 1 | 21,552 | Dustin Moseley | Lenny DiNardo | Santiago Casilla | Scot Shields | | 549 | 486 | 63 |
| 2007-08-04 | @ OAK | 109 | L 1-2 | 63-46 | 1 | 29,144 | Kelvim Escobar | Joe Blanton | Joe Blanton | Kelvim Escobar | Alan Embree | 550 | 488 | 62 |
| 2007-08-05 | @ OAK | 110 | W 4-3 | 64-46 | 1 | 26,782 | John Lackey | Dan Haren | John Lackey | Kiko Calero | Francisco Rodriguez | 554 | 491 | 63 |
| 2007-08-06 | vs BOS | 111 | W 4-2 | 65-46 | 1 | 44,142 | Jered Weaver | Curt Schilling | Justin Speier | Curt Schilling | Francisco Rodriguez | 558 | 493 | 65 |
| 2007-08-07 | vs BOS | 112 | W 10-4 | 66-46 | 1 | 44,177 | Joe Saunders | Tim Wakefield | Joe Saunders | Tim Wakefield | | 568 | 497 | 71 |
| 2007-08-08 | vs BOS | 113 | L 6-9 | 66-47 | 1 | 44,243 | Dustin Moseley | Jon Lester | Hideki Okajima | Justin Speier | Jonathan Papelbon | 574 | 506 | 68 |
| 2007-08-10 | vs MIN | 114 | W 10-1 | 67-47 | 1 | 43,810 | Kelvim Escobar | Scott Baker | Kelvim Escobar | Scott Baker | | 584 | 507 | 77 |
| 2007-08-11 | vs MIN | 115 | W 4-3 | 68-47 | 1 | 44,064 | John Lackey | Carlos Silva | John Lackey | Pat Neshek | Francisco Rodriguez | 588 | 510 | 78 |
| 2007-08-12 | vs MIN | 116 | W 6-2 | 69-47 | 1 | 43,911 | Jered Weaver | Boof Bonser | Jered Weaver | Boof Bonser | | 594 | 512 | 82 |
| 2007-08-14 | @ TOR | 117 | L 1-4 | 69-48 | 1 | 31,978 | Joe Saunders | Roy Halladay | Roy Halladay | Joe Saunders | | 595 | 516 | 79 |
| 2007-08-15 | @ TOR | 118 | L 1-2 | 69-49 | 1 | 30,353 | Dustin Moseley | Shaun Marcum | Shaun Marcum | Dustin Moseley | Jeremy Accardo | 596 | 518 | 78 |
| 2007-08-16 | @ TOR | 119 | W 4-3 | 70-49 | 1 | 27,861 | Kelvim Escobar | Dustin McGowan | Kelvim Escobar | Dustin McGowan | Francisco Rodriguez | 600 | 521 | 79 |
| 2007-08-17 | @ BOS | 120 | L 4-8 | 71-49 | 1 | 36,686 | John Lackey | Clay Buchholz | Clay Buchholz | John Lackey | Jonathan Papelbon | 604 | 529 | 75 |
| 2007-08-17 | @ BOS | 121 | W 7-5 | 71-49 | 1 | 36,538 | Ervin Santana | Josh Beckett | Francisco Rodriguez | Eric Gagne | | 611 | 534 | 77 |
| 2007-08-18 | @ BOS | 122 | L 5-10 | 71-50 | 1 | 36,652 | Jered Weaver | Curt Schilling | Curt Schilling | Jered Weaver | | 616 | 544 | 72 |
| 2007-08-19 | @ BOS | 123 | W 3-1 | 72-50 | 1 | 36,346 | Joe Saunders | Julian Tavarez | Joe Saunders | Julian Tavarez | Francisco Rodriguez | 619 | 545 | 74 |
| 2007-08-20 | vs NYA | 124 | W 7-6 | 73-50 | 1 | 44,249 | Dustin Moseley | Phil Hughes | Darren Oliver | Sean Henn | | 626 | 551 | 75 |
| 2007-08-21 | vs NYA | 125 | W 18-9 | 74-50 | 1 | 44,264 | Kelvim Escobar | Mike Mussina | Kelvim Escobar | Mike Mussina | Marcus Gwyn | 644 | 560 | 84 |
| 2007-08-22 | vs NYA | 126 | L 2-8 | 74-51 | 1 | 44,326 | John Lackey | Andy Pettitte | Andy Pettitte | John Lackey | | 646 | 568 | 78 |
| 2007-08-23 | vs TOR | 127 | L 4-5 | 74-52 | 1 | 41,009 | Ervin Santana | Jesse Litsch | Jesse Litsch | Ervin Santana | Jeremy Accardo | 650 | 573 | 77 |
| 2007-08-24 | vs TOR | 128 | W 3-0 | 75-52 | 1 | 41,131 | Jered Weaver | Roy Halladay | Jered Weaver | Roy Halladay | Francisco Rodriguez | 653 | 573 | 80 |
| 2007-08-25 | vs TOR | 129 | L 2-9 | 75-53 | 1 | 41,631 | Joe Saunders | Shaun Marcum | Shaun Marcum | Joe Saunders | | 655 | 582 | 73 |
| 2007-08-26 | vs TOR | 130 | W 3-1 | 76-53 | 1 | 40,565 | Kelvim Escobar | Dustin McGowan | Kelvim Escobar | Dustin McGowan | Francisco Rodriguez | 658 | 583 | 75 |
| 2007-08-27 | @ SEA | 131 | W 6-0 | 77-53 | 1 | 45,998 | John Lackey | Miguel Batista | John Lackey | Miguel Batista | | 664 | 583 | 81 |
| 2007-08-28 | @ SEA | 132 | W 10-6 | 78-53 | 1 | 44,395 | Ervin Santana | Jeff Weaver | Justin Speier | Brandon Morrow | | 674 | 589 | 85 |
| 2007-08-29 | @ SEA | 133 | W 8-2 | 79-53 | 1 | 46,047 | Jered Weaver | Felix Hernandez | Jered Weaver | Felix Hernandez | | 682 | 591 | 91 |
| 2007-08-31 | vs TEX | 134 | W 7-6 | 80-53 | 1 | 41,012 | Joe Saunders | Vicente Padilla | Darren Oliver | Frank Francisco | | 689 | 597 | 92 |
| 2007-09-01 | vs TEX | 135 | L 6-7 | 80-54 | 1 | 38,342 | Kelvim Escobar | Edinson Volquez | Edinson Volquez | Kelvim Escobar | C.J. Wilson | 695 | 604 | 91 |
| 2007-09-02 | vs TEX | 136 | L 7-8 | 80-55 | 1 | 40,635 | John Lackey | Kason Gabbard | Wes Littleton | Scot Shields | C.J. Wilson | 702 | 612 | 90 |
| 2007-09-03 | vs OAK | 137 | W 9-5 | 81-55 | 1 | 39,164 | Ervin Santana | Chad Gaudin | Ervin Santana | Chad Gaudin | | 711 | 617 | 94 |
| 2007-09-04 | vs OAK | 138 | W 4-3 | 82-55 | 1 | 39,017 | Jered Weaver | Lenny DiNardo | Jered Weaver | Lenny DiNardo | Francisco Rodriguez | 715 | 620 | 95 |
| 2007-09-05 | vs OAK | 139 | L 2-6 | 82-56 | 1 | 34,000 | Joe Saunders | Joe Blanton | Joe Blanton | Joe Saunders | | 717 | 626 | 91 |
| 2007-09-06 | vs CLE | 140 | W 10-3 | 83-56 | 1 | 41,720 | Kelvim Escobar | Paul Byrd | Kelvim Escobar | Paul Byrd | | 727 | 629 | 98 |
| 2007-09-07 | vs CLE | 141 | W 3-2 | 84-56 | 1 | 40,020 | John Lackey | Jake Westbrook | Scot Shields | Rafael Betancourt | | 730 | 631 | 99 |
| 2007-09-08 | vs CLE | 142 | L 1-6 | 84-57 | 1 | 43,544 | Ervin Santana | CC Sabathia | CC Sabathia | Ervin Santana | | 731 | 637 | 94 |
| 2007-09-09 | vs CLE | 143 | L 2-6 | 84-58 | 1 | 40,037 | Jered Weaver | Aaron Laffey | Aaron Laffey | Jered Weaver | | 733 | 643 | 90 |
| 2007-09-11 | @ BAL | 144 | W 10-5 | 85-58 | 1 | 15,371 | Joe Saunders | Victor Santos | Joe Saunders | Victor Santos | | 743 | 648 | 95 |
| 2007-09-12 | @ BAL | 145 | W 18-6 | 86-58 | 1 | 15,136 | Kelvim Escobar | Daniel Cabrera | Kelvim Escobar | Daniel Cabrera | | 761 | 654 | 107 |
| 2007-09-13 | @ BAL | 146 | L 0-3 | 86-59 | 1 | 16,359 | John Lackey | Jon Leicester | Jon Leicester | John Lackey | Jamie Walker | 761 | 657 | 104 |
| 2007-09-14 | @ CHA | 147 | L 3-5 | 86-60 | 1 | 33,581 | Bartolo Colon | Jose Contreras | Jose Contreras | Bartolo Colon | Bobby Jenks | 764 | 662 | 102 |
| 2007-09-15 | @ CHA | 148 | W 2-1 | 87-60 | 1 | 36,485 | Jered Weaver | Jon Garland | Jered Weaver | Jon Garland | Francisco Rodriguez | 766 | 663 | 103 |
| 2007-09-16 | @ CHA | 149 | L 7-9 | 87-61 | 1 | 29,010 | Joe Saunders | Mark Buehrle | Mike MacDougal | Dustin Moseley | | 773 | 672 | 101 |
| 2007-09-17 | vs TBA | 150 | W 10-7 | 88-61 | 1 | 37,530 | Kelvim Escobar | Edwin Jackson | Darren Oliver | Edwin Jackson | | 783 | 679 | 104 |
| 2007-09-18 | vs TBA | 151 | W 2-1 | 89-61 | 1 | 36,313 | John Lackey | Jason Hammel | John Lackey | Jason Hammel | Francisco Rodriguez | 785 | 680 | 105 |
| 2007-09-19 | vs TBA | 152 | W 2-1 | 90-61 | 1 | 33,699 | Ervin Santana | J.P. Howell | Ervin Santana | J.P. Howell | Francisco Rodriguez | 787 | 681 | 106 |
| 2007-09-20 | vs SEA | 153 | W 9-5 | 91-61 | 1 | 40,016 | Jered Weaver | Ryan Feierabend | Jered Weaver | Ryan Feierabend | | 796 | 686 | 110 |
| 2007-09-21 | vs SEA | 154 | L 0-6 | 91-62 | 1 | 44,018 | Joe Saunders | Jarrod Washburn | Jarrod Washburn | Joe Saunders | | 796 | 692 | 104 |
| 2007-09-22 | vs SEA | 155 | L 2-3 | 91-63 | 1 | 43,583 | Bartolo Colon | Miguel Batista | Miguel Batista | Bartolo Colon | J.J. Putz | 798 | 695 | 103 |
| 2007-09-23 | vs SEA | 156 | W 7-4 | 92-63 | 1 | 44,234 | John Lackey | Jeff Weaver | John Lackey | Jeff Weaver | Francisco Rodriguez | 805 | 699 | 106 |
| 2007-09-24 | @ TEX | 157 | L 7-8 | 92-64 | 1 | 22,881 | Ervin Santana | Armando Galarraga | Bill White | Ervin Santana | Wes Littleton | 812 | 707 | 105 |
| 2007-09-25 | @ TEX | 158 | L 1-3 | 92-65 | 1 | 30,708 | Dustin Moseley | A.J. Murray | Jamey Wright | Darren Oliver | | 813 | 710 | 103 |
| 2007-09-26 | @ TEX | 159 | L 2-16 | 92-66 | 1 | 24,223 | Joe Saunders | Luis Mendoza | John Rheinecker | Joe Saunders | | 815 | 726 | 89 |
| 2007-09-28 | @ OAK | 160 | W 2-0 | 93-66 | 1 | 32,287 | John Lackey | Dan Haren | John Lackey | Dan Haren | Francisco Rodriguez | 817 | 726 | 91 |
| 2007-09-29 | @ OAK | 161 | W 3-2 | 94-66 | 1 | 26,480 | Kelvim Escobar | Dallas Braden | Kelvim Escobar | Lenny DiNardo | Francisco Rodriguez | 820 | 728 | 92 |
| 2007-09-30 | @ OAK | 162 | L 2-3 | 94-67 | 1 | 28,062 | Jered Weaver | Chad Gaudin | Huston Street | Chris Bootcheck | | 822 | 731 | 91 |