| 2007-04-02 | vs ARI | 1 | L 6-8 | 0-1 | 2 | 48,169 | Aaron Cook | Brandon Webb | Juan Cruz | LaTroy Hawkins | Jose Valverde | 6 | 8 | -2 |
| 2007-04-03 | vs ARI | 2 | W 4-3 | 1-1 | 3 | 20,547 | Jeff Francis | Livan Hernandez | Byung-Hyun Kim | Jose Valverde | | 10 | 11 | -1 |
| 2007-04-04 | vs ARI | 3 | W 11-4 | 2-1 | 2 | 19,352 | Rodrigo Lopez | Doug Davis | Rodrigo Lopez | Doug Davis | | 21 | 15 | 6 |
| 2007-04-06 | @ SDN | 4 | W 4-3 | 3-1 | 1 | 44,267 | Jason Hirsh | Greg Maddux | Jason Hirsh | Greg Maddux | Brian Fuentes | 25 | 18 | 7 |
| 2007-04-07 | @ SDN | 5 | L 2-3 | 3-2 | 2 | 40,504 | Josh Fogg | David Wells | Trevor Hoffman | Manuel Corpas | | 27 | 21 | 6 |
| 2007-04-08 | @ SDN | 6 | L 1-2 | 3-3 | 4 | 27,086 | Aaron Cook | Jake Peavy | Scott Linebrink | LaTroy Hawkins | | 28 | 23 | 5 |
| 2007-04-09 | @ LAN | 7 | W 6-3 | 4-3 | 3 | 56,000 | Jeff Francis | Jason Schmidt | Jeff Francis | Jason Schmidt | | 34 | 26 | 8 |
| 2007-04-10 | @ LAN | 8 | L 1-2 | 4-4 | 4 | 40,560 | Rodrigo Lopez | Brett Tomko | Joe Beimel | Byung-Hyun Kim | Takashi Saito | 35 | 28 | 7 |
| 2007-04-11 | @ LAN | 9 | L 0-3 | 4-5 | 4 | 35,852 | Jason Hirsh | Brad Penny | Brad Penny | Jason Hirsh | Takashi Saito | 35 | 31 | 4 |
| 2007-04-13 | @ ARI | 10 | W 6-3 | 5-5 | 4 | 20,219 | Josh Fogg | Brandon Webb | Jeremy Affeldt | Brandon Webb | Brian Fuentes | 41 | 34 | 7 |
| 2007-04-14 | @ ARI | 11 | L 4-5 | 5-6 | 4 | 27,721 | Aaron Cook | Livan Hernandez | Brandon Lyon | LaTroy Hawkins | Jose Valverde | 45 | 39 | 6 |
| 2007-04-15 | @ ARI | 12 | L 4-6 | 5-7 | 4 | 21,904 | Byung-Hyun Kim | Doug Davis | Doug Davis | Byung-Hyun Kim | Jose Valverde | 49 | 45 | 4 |
| 2007-04-16 | vs SFN | 13 | L 0-8 | 5-8 | 4 | 18,222 | Jeff Francis | Barry Zito | Barry Zito | Jeff Francis | | 49 | 53 | -4 |
| 2007-04-17 | vs SFN | 14 | W 5-3 | 6-8 | 4 | 18,207 | Jason Hirsh | Matt Cain | Ramon Ramirez | Kevin Correia | Brian Fuentes | 54 | 56 | -2 |
| 2007-04-18 | vs LAN | 15 | W 7-2 | 7-8 | 4 | 20,366 | Rodrigo Lopez | Derek Lowe | Taylor Buchholz | Derek Lowe | | 61 | 58 | 3 |
| 2007-04-19 | vs LAN | 16 | L 1-8 | 7-9 | 4 | 19,135 | Aaron Cook | Mark Hendrickson | Mark Hendrickson | Aaron Cook | | 62 | 66 | -4 |
| 2007-04-20 | vs SDN | 17 | L 1-11 | 7-10 | 5 | 22,338 | Josh Fogg | Chris Young | Chris Young | Josh Fogg | | 63 | 77 | -14 |
| 2007-04-21 | vs SDN | 18 | L 3-7 | 7-11 | 5 | 22,795 | Jeff Francis | Clay Hensley | Clay Hensley | Jeff Francis | | 66 | 84 | -18 |
| 2007-04-22 | vs SDN | 19 | W 4-2 | 8-11 | 5 | 25,746 | Jason Hirsh | Greg Maddux | Jason Hirsh | Greg Maddux | Brian Fuentes | 70 | 86 | -16 |
| 2007-04-23 | @ NYN | 20 | L 1-6 | 8-12 | 5 | 32,154 | Taylor Buchholz | John Maine | John Maine | Taylor Buchholz | | 71 | 92 | -21 |
| 2007-04-24 | @ NYN | 21 | L 1-2 | 8-13 | 5 | 38,500 | Aaron Cook | Orlando Hernandez | Joe Smith | Ryan Speier | | 72 | 94 | -22 |
| 2007-04-25 | @ NYN | 22 | W 11-5 | 9-13 | 5 | 33,522 | Josh Fogg | Mike Pelfrey | Josh Fogg | Mike Pelfrey | | 83 | 99 | -16 |
| 2007-04-27 | vs ATL | 23 | L 7-9 | 9-14 | 5 | 25,079 | Jeff Francis | Chuck James | Chuck James | Jeff Francis | Peter Moylan | 90 | 108 | -18 |
| 2007-04-28 | vs ATL | 24 | L 2-6 | 9-15 | 5 | 28,178 | Jason Hirsh | John Smoltz | John Smoltz | Jason Hirsh | | 92 | 114 | -22 |
| 2007-04-29 | vs ATL | 25 | W 9-7 | 10-15 | 5 | 31,445 | Aaron Cook | Kyle Davies | Denny Bautista | Steve Colyer | | 101 | 121 | -20 |
| 2007-04-30 | @ SFN | 26 | L 5-9 | 10-16 | 5 | 34,659 | Josh Fogg | Noah Lowry | Noah Lowry | Josh Fogg | | 106 | 130 | -24 |
| 2007-05-01 | @ SFN | 27 | W 9-7 | 11-16 | 5 | 33,210 | Taylor Buchholz | Russ Ortiz | Alberto Arias | Russ Ortiz | Brian Fuentes | 115 | 137 | -22 |
| 2007-05-02 | @ SFN | 28 | L 3-5 | 11-17 | 5 | 32,557 | Jeff Francis | Barry Zito | Brad Hennessey | Jeff Francis | | 118 | 142 | -24 |
| 2007-05-04 | @ CIN | 29 | W 6-5 | 12-17 | 5 | 23,920 | Jason Hirsh | Matt Belisle | Denny Bautista | Mike Stanton | Brian Fuentes | 124 | 147 | -23 |
| 2007-05-05 | @ CIN | 30 | W 9-7 | 13-17 | 5 | 26,663 | Aaron Cook | Aaron Harang | Aaron Cook | Aaron Harang | Brian Fuentes | 133 | 154 | -21 |
| 2007-05-06 | @ CIN | 31 | L 3-9 | 13-18 | 5 | 27,915 | Josh Fogg | Bronson Arroyo | Bronson Arroyo | Josh Fogg | David Weathers | 136 | 163 | -27 |
| 2007-05-07 | @ SLN | 32 | W 3-2 | 14-18 | 5 | 42,285 | Jeff Francis | Anthony Reyes | Zach McClellan | Brian Falkenborg | Brian Fuentes | 139 | 165 | -26 |
| 2007-05-08 | @ SLN | 33 | L 1-4 | 14-19 | 5 | 42,763 | Taylor Buchholz | Brad Thompson | Kelvin Jimenez | Denny Bautista | Jason Isringhausen | 140 | 169 | -29 |
| 2007-05-09 | @ SLN | 34 | L 2-9 | 14-20 | 5 | 43,001 | Jason Hirsh | Adam Wainwright | Adam Wainwright | Jason Hirsh | | 142 | 178 | -36 |
| 2007-05-10 | vs SFN | 35 | W 5-3 | 15-20 | 5 | 20,120 | Aaron Cook | Noah Lowry | Aaron Cook | Noah Lowry | Brian Fuentes | 147 | 181 | -34 |
| 2007-05-11 | vs SFN | 36 | L 3-8 | 15-21 | 5 | 26,162 | Josh Fogg | Tim Lincecum | Tim Lincecum | Josh Fogg | | 150 | 189 | -39 |
| 2007-05-12 | vs SFN | 37 | W 6-2 | 16-21 | 5 | 33,569 | Jeff Francis | Barry Zito | Jeff Francis | Barry Zito | | 156 | 191 | -35 |
| 2007-05-13 | vs SFN | 38 | L 2-15 | 16-22 | 5 | 24,243 | Taylor Buchholz | Matt Cain | Matt Cain | Taylor Buchholz | | 158 | 206 | -48 |
| 2007-05-15 | vs ARI | 39 | L 0-3 | 16-23 | 5 | 20,178 | Jason Hirsh | Randy Johnson | Randy Johnson | Jason Hirsh | Jose Valverde | 158 | 209 | -51 |
| 2007-05-16 | vs ARI | 40 | W 5-3 | 17-23 | 5 | 20,023 | Aaron Cook | Brandon Webb | Aaron Cook | Brandon Webb | Brian Fuentes | 163 | 212 | -49 |
| 2007-05-17 | vs ARI | 41 | L 1-3 | 17-24 | 5 | 23,610 | Josh Fogg | Livan Hernandez | Livan Hernandez | Josh Fogg | Jose Valverde | 164 | 215 | -51 |
| 2007-05-18 | vs KCA | 42 | L 2-5 | 17-25 | 5 | 22,399 | Jeff Francis | Jorge de la Rosa | Brandon Duckworth | Manuel Corpas | Joakim Soria | 166 | 220 | -54 |
| 2007-05-19 | vs KCA | 43 | W 6-4 | 18-25 | 5 | 24,017 | Taylor Buchholz | Gil Meche | Taylor Buchholz | Gil Meche | Brian Fuentes | 172 | 224 | -52 |
| 2007-05-20 | vs KCA | 44 | L 5-10 | 18-26 | 5 | 25,829 | Jason Hirsh | Brian Bannister | Joel Peralta | Ramon Ramirez | | 177 | 234 | -57 |
| 2007-05-21 | @ ARI | 45 | L 5-6 | 18-27 | 5 | 19,782 | Aaron Cook | Brandon Webb | Doug Slaten | Jeremy Affeldt | Jose Valverde | 182 | 240 | -58 |
| 2007-05-22 | @ ARI | 46 | W 3-1 | 19-27 | 5 | 23,058 | Josh Fogg | Livan Hernandez | Manuel Corpas | Brandon Lyon | Brian Fuentes | 185 | 241 | -56 |
| 2007-05-23 | @ ARI | 47 | W 2-0 | 20-27 | 5 | 18,373 | Jeff Francis | Doug Davis | Jeff Francis | Doug Davis | Brian Fuentes | 187 | 241 | -54 |
| 2007-05-25 | @ SFN | 48 | W 5-3 | 21-27 | 5 | 41,274 | Jason Hirsh | Matt Cain | Jeremy Affeldt | Armando Benitez | Brian Fuentes | 192 | 244 | -52 |
| 2007-05-26 | @ SFN | 49 | W 6-1 | 22-27 | 5 | 38,212 | Aaron Cook | Matt Morris | Aaron Cook | Matt Morris | | 198 | 245 | -47 |
| 2007-05-27 | @ SFN | 50 | W 6-4 | 23-27 | 5 | 41,708 | Taylor Buchholz | Noah Lowry | Ramon Ramirez | Steve Kline | Brian Fuentes | 204 | 249 | -45 |
| 2007-05-28 | vs SLN | 51 | W 6-2 | 24-27 | 5 | 31,575 | Jeff Francis | Kip Wells | Jeff Francis | Kip Wells | | 210 | 251 | -41 |
| 2007-05-29 | vs SLN | 52 | W 8-3 | 25-27 | 4 | 18,213 | Rodrigo Lopez | Braden Looper | Rodrigo Lopez | Braden Looper | | 218 | 254 | -36 |
| 2007-05-30 | vs SLN | 53 | L 4-8 | 25-28 | 5 | 19,062 | Jason Hirsh | Todd Wellemeyer | Todd Wellemeyer | Jason Hirsh | | 222 | 262 | -40 |
| 2007-05-31 | vs SLN | 54 | L 3-7 | 25-29 | 5 | 19,097 | Aaron Cook | Brad Thompson | Brad Thompson | Aaron Cook | | 225 | 269 | -44 |
| 2007-06-01 | vs CIN | 55 | L 2-4 | 25-30 | 5 | 22,265 | Taylor Buchholz | Bobby Livingston | Bobby Livingston | Taylor Buchholz | David Weathers | 227 | 273 | -46 |
| 2007-06-02 | vs CIN | 56 | W 4-1 | 26-30 | 5 | 30,076 | Jeff Francis | Kyle Lohse | Jeff Francis | Kyle Lohse | Brian Fuentes | 231 | 274 | -43 |
| 2007-06-03 | vs CIN | 57 | W 10-9 | 27-30 | 4 | 26,071 | Rodrigo Lopez | Matt Belisle | Manuel Corpas | Victor Santos | | 241 | 283 | -42 |
| 2007-06-05 | vs HOU | 58 | L 1-4 | 27-31 | 5 | 27,101 | Jason Hirsh | Wandy Rodriguez | Wandy Rodriguez | Jason Hirsh | Dan Wheeler | 242 | 287 | -45 |
| 2007-06-06 | vs HOU | 59 | W 8-7 | 28-31 | 4 | 22,471 | Aaron Cook | Woody Williams | Taylor Buchholz | Woody Williams | Brian Fuentes | 250 | 294 | -44 |
| 2007-06-07 | vs HOU | 60 | W 7-6 | 29-31 | 4 | 22,103 | Josh Fogg | Roy Oswalt | Jeremy Affeldt | Dan Wheeler | | 257 | 300 | -43 |
| 2007-06-08 | @ BAL | 61 | L 2-4 | 29-32 | 4 | 22,375 | Jeff Francis | Steve Trachsel | Steve Trachsel | Jeff Francis | Chris Ray | 259 | 304 | -45 |
| 2007-06-09 | @ BAL | 62 | W 3-2 | 30-32 | 4 | 27,320 | Rodrigo Lopez | Jeremy Guthrie | Jeremy Affeldt | Todd Williams | Brian Fuentes | 262 | 306 | -44 |
| 2007-06-10 | @ BAL | 63 | W 6-1 | 31-32 | 4 | 34,784 | Jason Hirsh | Erik Bedard | Jason Hirsh | Erik Bedard | | 268 | 307 | -39 |
| 2007-06-12 | @ BOS | 64 | L 1-2 | 31-33 | 4 | 37,008 | Aaron Cook | Tim Wakefield | Tim Wakefield | Aaron Cook | Jonathan Papelbon | 269 | 309 | -40 |
| 2007-06-13 | @ BOS | 65 | W 12-2 | 32-33 | 4 | 36,808 | Josh Fogg | Curt Schilling | Josh Fogg | Curt Schilling | | 281 | 311 | -30 |
| 2007-06-14 | @ BOS | 66 | W 7-1 | 33-33 | 4 | 36,939 | Jeff Francis | Josh Beckett | Jeff Francis | Josh Beckett | | 288 | 312 | -24 |
| 2007-06-15 | vs TBA | 67 | W 12-2 | 34-33 | 4 | 25,762 | Rodrigo Lopez | James Shields | Rodrigo Lopez | James Shields | | 300 | 314 | -14 |
| 2007-06-16 | vs TBA | 68 | W 10-5 | 35-33 | 4 | 30,101 | Jason Hirsh | Andy Sonnanstine | Taylor Buchholz | Andy Sonnanstine | | 310 | 319 | -9 |
| 2007-06-17 | vs TBA | 69 | L 4-7 | 35-34 | 4 | 31,190 | Aaron Cook | Scott Kazmir | Scott Kazmir | Aaron Cook | Alberto Reyes | 314 | 326 | -12 |
| 2007-06-19 | vs NYA | 70 | W 3-1 | 36-34 | 4 | 48,077 | Josh Fogg | Mike Mussina | Josh Fogg | Mike Mussina | Brian Fuentes | 317 | 327 | -10 |
| 2007-06-20 | vs NYA | 71 | W 6-1 | 37-34 | 4 | 48,440 | Jeff Francis | Andy Pettitte | Jeff Francis | Andy Pettitte | | 323 | 328 | -5 |
| 2007-06-21 | vs NYA | 72 | W 4-3 | 38-34 | 4 | 48,611 | Rodrigo Lopez | Roger Clemens | Rodrigo Lopez | Roger Clemens | Brian Fuentes | 327 | 331 | -4 |
| 2007-06-22 | @ TOR | 73 | L 8-9 | 38-35 | 4 | 27,369 | Jason Hirsh | Josh Towers | Brian Wolfe | Brian Fuentes | | 335 | 340 | -5 |
| 2007-06-23 | @ TOR | 74 | L 6-11 | 38-36 | 4 | 32,482 | Aaron Cook | Ty Taubenheim | Brian Wolfe | Aaron Cook | | 341 | 351 | -10 |
| 2007-06-24 | @ TOR | 75 | L 0-5 | 38-37 | 4 | 33,910 | Josh Fogg | Dustin McGowan | Dustin McGowan | Josh Fogg | | 341 | 356 | -15 |
| 2007-06-25 | @ CHN | 76 | L 9-10 | 38-38 | 4 | 40,269 | Jeff Francis | Jason Marquis | Bob Howry | Brian Fuentes | | 350 | 366 | -16 |
| 2007-06-26 | @ CHN | 77 | L 5-8 | 38-39 | 4 | 40,121 | Rodrigo Lopez | Ted Lilly | Ted Lilly | Rodrigo Lopez | Will Ohman | 355 | 374 | -19 |
| 2007-06-27 | @ CHN | 78 | L 4-6 | 38-40 | 4 | 39,972 | Jason Hirsh | Carlos Zambrano | Carlos Zambrano | Jason Hirsh | Carlos Marmol | 359 | 380 | -21 |
| 2007-06-28 | @ HOU | 79 | L 5-8 | 38-41 | 4 | 42,537 | Aaron Cook | Roy Oswalt | Brian Moehler | Brian Fuentes | | 364 | 388 | -24 |
| 2007-06-29 | @ HOU | 80 | L 8-9 | 38-42 | 4 | 42,861 | Josh Fogg | Chris Sampson | Dave Borkowski | Brian Fuentes | | 372 | 397 | -25 |
| 2007-06-30 | @ HOU | 81 | W 5-0 | 39-42 | 4 | 43,071 | Jeff Francis | Jason Jennings | Jeff Francis | Jason Jennings | | 377 | 397 | -20 |
| 2007-07-01 | @ HOU | 82 | L 0-12 | 39-43 | 4 | 35,260 | Rodrigo Lopez | Wandy Rodriguez | Wandy Rodriguez | Rodrigo Lopez | | 377 | 409 | -32 |
| 2007-07-02 | vs NYN | 83 | W 6-2 | 40-43 | 4 | 27,252 | Jason Hirsh | Tom Glavine | Jason Hirsh | Tom Glavine | | 383 | 411 | -28 |
| 2007-07-03 | vs NYN | 84 | W 11-3 | 41-43 | 4 | 48,040 | Aaron Cook | Jason Vargas | Aaron Cook | Jason Vargas | | 394 | 414 | -20 |
| 2007-07-04 | vs NYN | 85 | W 17-7 | 42-43 | 4 | 48,123 | Josh Fogg | Orlando Hernandez | Josh Fogg | Orlando Hernandez | | 411 | 421 | -10 |
| 2007-07-06 | vs PHI | 86 | W 7-6 | 43-43 | 4 | 29,239 | Jeff Francis | Kyle Kendrick | Manuel Corpas | J.D. Durbin | | 418 | 427 | -9 |
| 2007-07-07 | vs PHI | 87 | W 6-3 | 44-43 | 4 | 35,196 | Rodrigo Lopez | Jamie Moyer | Rodrigo Lopez | Jamie Moyer | Manuel Corpas | 424 | 430 | -6 |
| 2007-07-08 | vs PHI | 88 | L 4-8 | 44-44 | 4 | 25,119 | Aaron Cook | Adam Eaton | Adam Eaton | Aaron Cook | Ryan Madson | 428 | 438 | -10 |
| 2007-07-13 | @ MIL | 89 | W 10-6 | 45-44 | 4 | 37,690 | Jeff Francis | Chris Capuano | Jeff Francis | Carlos Villanueva | | 438 | 444 | -6 |
| 2007-07-14 | @ MIL | 90 | L 1-2 | 45-45 | 4 | 42,559 | Rodrigo Lopez | Ben Sheets | Derrick Turnbow | LaTroy Hawkins | | 439 | 446 | -7 |
| 2007-07-15 | @ MIL | 91 | L 3-4 | 45-46 | 4 | 42,754 | Aaron Cook | Jeff Suppan | Matt Wise | Jeremy Affeldt | Francisco Cordero | 442 | 450 | -8 |
| 2007-07-16 | @ PIT | 92 | W 10-8 | 46-46 | 4 | 16,423 | Taylor Buchholz | John Van Benschoten | LaTroy Hawkins | John Van Benschoten | Manuel Corpas | 452 | 458 | -6 |
| 2007-07-17 | @ PIT | 93 | W 6-2 | 47-46 | 4 | 21,604 | Josh Fogg | Shane Youman | Josh Fogg | Shane Youman | | 458 | 460 | -2 |
| 2007-07-18 | @ PIT | 94 | W 5-3 | 48-46 | 4 | 19,285 | Jeff Francis | Ian Snell | Jeff Francis | Ian Snell | Manuel Corpas | 463 | 463 | 0 |
| 2007-07-19 | @ WAS | 95 | L 4-5 | 48-47 | 4 | 20,573 | Ubaldo Jimenez | Matt Chico | Jon Rauch | LaTroy Hawkins | | 467 | 468 | -1 |
| 2007-07-20 | @ WAS | 96 | W 3-1 | 49-47 | 3 | 27,581 | Aaron Cook | Billy Traber | Aaron Cook | Billy Traber | Manuel Corpas | 470 | 469 | 1 |
| 2007-07-21 | @ WAS | 97 | L 0-3 | 49-48 | 4 | 31,674 | Rodrigo Lopez | Michael Bacsik | Michael Bacsik | Rodrigo Lopez | Chad Cordero | 470 | 472 | -2 |
| 2007-07-22 | @ WAS | 98 | L 0-3 | 49-49 | 4 | 21,793 | Josh Fogg | Tim Redding | Jon Rauch | Jorge Julio | Chad Cordero | 470 | 475 | -5 |
| 2007-07-23 | vs SDN | 99 | W 7-5 | 50-49 | 4 | 31,047 | Jeff Francis | Greg Maddux | Taylor Buchholz | Scott Linebrink | Manuel Corpas | 477 | 480 | -3 |
| 2007-07-24 | vs SDN | 100 | L 3-5 | 50-50 | 4 | 37,127 | Ubaldo Jimenez | Chris Young | Heath Bell | Ramon Ramirez | Trevor Hoffman | 480 | 485 | -5 |
| 2007-07-25 | vs SDN | 101 | W 10-2 | 51-50 | 4 | 28,162 | Aaron Cook | Justin Germano | Aaron Cook | Justin Germano | | 490 | 487 | 3 |
| 2007-07-26 | vs LAN | 102 | L 4-5 | 51-51 | 4 | 31,057 | Rodrigo Lopez | Brad Penny | Brad Penny | Rodrigo Lopez | Takashi Saito | 494 | 492 | 2 |
| 2007-07-28 | vs LAN | 103 | W 6-2 | 52-51 | 4 | 46,039 | Jeff Francis | Brett Tomko | Jeff Francis | Brett Tomko | | 500 | 494 | 6 |
| 2007-07-29 | vs LAN | 104 | W 9-6 | 53-51 | 4 | 38,167 | Ubaldo Jimenez | Chad Billingsley | Ubaldo Jimenez | Chad Billingsley | Manuel Corpas | 509 | 500 | 9 |
| 2007-07-31 | @ FLO | 105 | W 6-3 | 54-51 | 4 | 11,534 | Aaron Cook | Scott Olsen | Aaron Cook | Scott Olsen | Manuel Corpas | 515 | 503 | 12 |
| 2007-08-01 | @ FLO | 106 | L 3-4 | 54-52 | 4 | 11,556 | Josh Fogg | Byung-Hyun Kim | Byung-Hyun Kim | Josh Fogg | Kevin Gregg | 518 | 507 | 11 |
| 2007-08-02 | @ FLO | 107 | W 4-3 | 55-52 | 4 | 11,927 | Jason Hirsh | Rick Vanden Hurk | LaTroy Hawkins | Armando Benitez | Manuel Corpas | 522 | 510 | 12 |
| 2007-08-03 | @ ATL | 108 | W 9-2 | 56-52 | 4 | 37,481 | Jeff Francis | John Smoltz | Jeff Francis | John Smoltz | | 531 | 512 | 19 |
| 2007-08-04 | @ ATL | 109 | L 4-6 | 56-53 | 4 | 50,647 | Ubaldo Jimenez | Tim Hudson | Tim Hudson | Ubaldo Jimenez | Bob Wickman | 535 | 518 | 17 |
| 2007-08-05 | @ ATL | 110 | L 5-6 | 56-54 | 4 | 37,089 | Aaron Cook | Chuck James | Oscar Villarreal | Taylor Buchholz | | 540 | 524 | 16 |
| 2007-08-06 | vs MIL | 111 | W 6-2 | 57-54 | 4 | 29,555 | Josh Fogg | Claudio Vargas | Josh Fogg | Claudio Vargas | | 546 | 526 | 20 |
| 2007-08-07 | vs MIL | 112 | W 11-4 | 58-54 | 3 | 30,280 | Jason Hirsh | Chris Capuano | Jason Hirsh | Chris Capuano | | 557 | 530 | 27 |
| 2007-08-08 | vs MIL | 113 | W 19-4 | 59-54 | 3 | 26,613 | Jeff Francis | Yovani Gallardo | Jeff Francis | Yovani Gallardo | | 576 | 534 | 42 |
| 2007-08-09 | vs CHN | 114 | L 2-10 | 59-55 | 3 | 40,738 | Ubaldo Jimenez | Ted Lilly | Ted Lilly | Ubaldo Jimenez | | 578 | 544 | 34 |
| 2007-08-10 | vs CHN | 115 | L 2-6 | 59-56 | 4 | 41,282 | Aaron Cook | Jason Marquis | Jason Marquis | Aaron Cook | | 580 | 550 | 30 |
| 2007-08-11 | vs CHN | 116 | W 15-2 | 60-56 | 3 | 48,095 | Josh Fogg | Rich Hill | Josh Fogg | Rich Hill | | 595 | 552 | 43 |
| 2007-08-12 | vs CHN | 117 | W 6-3 | 61-56 | 3 | 39,176 | Tim Harikkala | Sean Marshall | Matt Herges | Kerry Wood | Manuel Corpas | 601 | 555 | 46 |
| 2007-08-14 | @ SDN | 118 | L 0-8 | 61-57 | 3 | 32,049 | Jeff Francis | Greg Maddux | Greg Maddux | Jeff Francis | | 601 | 563 | 38 |
| 2007-08-15 | @ SDN | 119 | W 3-0 | 62-57 | 3 | 36,864 | Ubaldo Jimenez | Chris Young | Ubaldo Jimenez | Cla Meredith | Manuel Corpas | 604 | 563 | 41 |
| 2007-08-16 | @ SDN | 120 | L 9-11 | 62-58 | 3 | 28,198 | Elmer Dessens | Clay Hensley | Clay Hensley | Jeremy Affeldt | Trevor Hoffman | 613 | 574 | 39 |
| 2007-08-17 | @ LAN | 121 | L 4-6 | 62-59 | 4 | 48,072 | Josh Fogg | Eric Stults | Eric Stults | Josh Fogg | Takashi Saito | 617 | 580 | 37 |
| 2007-08-18 | @ LAN | 122 | W 7-4 | 63-59 | 3 | 52,508 | Franklin Morales | Chad Billingsley | Matt Herges | Roberto Hernandez | Manuel Corpas | 624 | 584 | 40 |
| 2007-08-19 | @ LAN | 123 | L 3-4 | 63-60 | 4 | 48,732 | Jeff Francis | Brad Penny | Scott Proctor | Jorge Julio | Takashi Saito | 627 | 588 | 39 |
| 2007-08-20 | vs PIT | 124 | L 2-4 | 63-61 | 4 | 22,682 | Ubaldo Jimenez | Matt Morris | Damaso Marte | Brian Fuentes | Matt Capps | 629 | 592 | 37 |
| 2007-08-21 | vs PIT | 125 | W 9-2 | 64-61 | 3 | 21,136 | Elmer Dessens | Tony Armas | Taylor Buchholz | Tony Armas | | 638 | 594 | 44 |
| 2007-08-22 | vs PIT | 126 | L 2-11 | 64-62 | 4 | 20,629 | Josh Fogg | Tom Gorzelanny | Tom Gorzelanny | Josh Fogg | | 640 | 605 | 35 |
| 2007-08-23 | vs PIT | 127 | L 1-5 | 64-63 | 4 | 20,380 | Franklin Morales | Paul Maholm | Paul Maholm | Franklin Morales | | 641 | 610 | 31 |
| 2007-08-24 | vs WAS | 128 | W 6-5 | 65-63 | 4 | 25,232 | Jeff Francis | Shawn Hill | Brian Fuentes | Chad Cordero | | 647 | 615 | 32 |
| 2007-08-25 | vs WAS | 129 | W 5-1 | 66-63 | 3 | 27,179 | Ubaldo Jimenez | Tim Redding | Ubaldo Jimenez | Tim Redding | | 652 | 616 | 36 |
| 2007-08-26 | vs WAS | 130 | W 10-5 | 67-63 | 3 | 24,086 | Elmer Dessens | Joel Hanrahan | Elmer Dessens | Joel Hanrahan | | 662 | 621 | 41 |
| 2007-08-27 | @ SFN | 131 | L 1-4 | 67-64 | 4 | 35,726 | Josh Fogg | Barry Zito | Brian Wilson | Jorge Julio | Brad Hennessey | 663 | 625 | 38 |
| 2007-08-28 | @ SFN | 132 | L 1-3 | 67-65 | 4 | 37,844 | Franklin Morales | Matt Cain | Matt Cain | Franklin Morales | Brad Hennessey | 664 | 628 | 36 |
| 2007-08-29 | @ SFN | 133 | W 8-0 | 68-65 | 4 | 38,397 | Jeff Francis | Noah Lowry | Jeff Francis | Noah Lowry | | 672 | 628 | 44 |
| 2007-08-31 | @ ARI | 134 | W 7-3 | 69-65 | 4 | 26,127 | Ubaldo Jimenez | Livan Hernandez | Matt Herges | Tony Pena | | 679 | 631 | 48 |
| 2007-09-01 | @ ARI | 135 | L 7-13 | 69-66 | 4 | 29,119 | Elmer Dessens | Dana Eveland | Edgar Gonzalez | Elmer Dessens | | 686 | 644 | 42 |
| 2007-09-02 | @ ARI | 136 | W 4-3 | 70-66 | 4 | 26,776 | Josh Fogg | Brandon Webb | Josh Fogg | Brandon Webb | Manuel Corpas | 690 | 647 | 43 |
| 2007-09-03 | vs SFN | 137 | W 7-4 | 71-66 | 4 | 30,168 | Jeff Francis | Matt Cain | Jeff Francis | Matt Cain | Manuel Corpas | 697 | 651 | 46 |
| 2007-09-04 | vs SFN | 138 | W 6-5 | 72-66 | 4 | 20,553 | Franklin Morales | Tim Lincecum | Manuel Corpas | Brad Hennessey | | 703 | 656 | 47 |
| 2007-09-05 | vs SFN | 139 | L 3-5 | 72-67 | 4 | 22,157 | Ubaldo Jimenez | Kevin Correia | Kevin Correia | Ubaldo Jimenez | Brad Hennessey | 706 | 661 | 45 |
| 2007-09-07 | vs SDN | 140 | W 10-4 | 73-67 | 4 | 27,247 | Elmer Dessens | Justin Germano | Matt Herges | Justin Germano | | 716 | 665 | 51 |
| 2007-09-08 | vs SDN | 141 | L 1-3 | 73-68 | 4 | 30,429 | Jeff Francis | Greg Maddux | Greg Maddux | Jeff Francis | Trevor Hoffman | 717 | 668 | 49 |
| 2007-09-09 | vs SDN | 142 | W 4-2 | 74-68 | 4 | 20,260 | Josh Fogg | Chris Young | Josh Fogg | Chris Young | Manuel Corpas | 721 | 670 | 51 |
| 2007-09-10 | @ PHI | 143 | L 5-6 | 74-69 | 4 | 25,046 | Ubaldo Jimenez | Kyle Lohse | Brett Myers | Taylor Buchholz | | 726 | 676 | 50 |
| 2007-09-11 | @ PHI | 144 | W 8-2 | 75-69 | 3 | 25,263 | Franklin Morales | Adam Eaton | Franklin Morales | Adam Eaton | | 734 | 678 | 56 |
| 2007-09-12 | @ PHI | 145 | W 12-0 | 76-69 | 3 | 31,541 | Denny Bautista | Kyle Kendrick | Mark Redman | Kyle Kendrick | | 746 | 678 | 68 |
| 2007-09-13 | @ PHI | 146 | L 4-12 | 76-70 | 4 | 42,623 | Jeff Francis | J.D. Durbin | Geoff Geary | Jeff Francis | | 750 | 690 | 60 |
| 2007-09-14 | vs FLO | 147 | L 6-7 | 76-71 | 4 | 22,400 | Josh Fogg | Dontrelle Willis | Dontrelle Willis | Matt Herges | Kevin Gregg | 756 | 697 | 59 |
| 2007-09-15 | vs FLO | 148 | L 2-10 | 76-72 | 4 | 26,079 | Ubaldo Jimenez | Sergio Mitre | Logan Kensing | Ubaldo Jimenez | | 758 | 707 | 51 |
| 2007-09-16 | vs FLO | 149 | W 13-0 | 77-72 | 4 | 19,161 | Franklin Morales | Scott Olsen | Franklin Morales | Scott Olsen | | 771 | 707 | 64 |
| 2007-09-18 | vs LAN | 150 | W 3-1 | 78-72 | 4 | 23,282 | Jeff Francis | Chad Billingsley | Jeff Francis | Chad Billingsley | Manuel Corpas | 774 | 708 | 66 |
| 2007-09-18 | vs LAN | 151 | W 9-8 | 78-72 | 4 | 23,271 | Mark Redman | David Wells | Ryan Speier | Takashi Saito | | 783 | 716 | 67 |
| 2007-09-19 | vs LAN | 152 | W 6-5 | 79-72 | 3 | 26,184 | Josh Fogg | Brad Penny | Brian Fuentes | Jonathan Broxton | Manuel Corpas | 789 | 721 | 68 |
| 2007-09-20 | vs LAN | 153 | W 9-4 | 80-72 | 3 | 23,147 | Ubaldo Jimenez | Derek Lowe | Ubaldo Jimenez | Derek Lowe | | 798 | 725 | 73 |
| 2007-09-21 | @ SDN | 154 | W 2-1 | 81-72 | 3 | 31,288 | Franklin Morales | Jake Peavy | Matt Herges | Joe Thatcher | | 800 | 726 | 74 |
| 2007-09-22 | @ SDN | 155 | W 6-2 | 82-72 | 3 | 35,020 | Mark Redman | Jack Cassel | Ryan Speier | Jack Cassel | | 806 | 728 | 78 |
| 2007-09-23 | @ SDN | 156 | W 7-3 | 83-72 | 3 | 37,984 | Jeff Francis | Greg Maddux | Jeff Francis | Greg Maddux | | 813 | 731 | 82 |
| 2007-09-25 | @ LAN | 157 | W 9-7 | 84-72 | 3 | 44,660 | Ubaldo Jimenez | Brad Penny | Ryan Speier | Mark Hendrickson | Manuel Corpas | 822 | 738 | 84 |
| 2007-09-26 | @ LAN | 158 | W 2-0 | 85-72 | 3 | 45,036 | Josh Fogg | Derek Lowe | Josh Fogg | Derek Lowe | Manuel Corpas | 824 | 738 | 86 |
| 2007-09-27 | @ LAN | 159 | W 10-4 | 86-72 | 3 | 51,999 | Franklin Morales | Esteban Loaiza | Franklin Morales | Esteban Loaiza | | 834 | 742 | 92 |
| 2007-09-28 | vs ARI | 160 | L 2-4 | 86-73 | 3 | 48,190 | Jeff Francis | Brandon Webb | Brandon Webb | Jeff Francis | Jose Valverde | 836 | 746 | 90 |
| 2007-09-29 | vs ARI | 161 | W 11-1 | 87-73 | 3 | 47,368 | Mark Redman | Edgar Gonzalez | Mark Redman | Edgar Gonzalez | | 847 | 747 | 100 |
| 2007-09-30 | vs ARI | 162 | W 4-3 | 88-73 | 3 | 46,375 | Ubaldo Jimenez | Yusmeiro Petit | Brian Fuentes | Dustin Nippert | Manuel Corpas | 851 | 750 | 101 |
| 2007-10-01 | vs SDN | 163 | W 9-8 | 89-73 | 2 | 48,404 | Josh Fogg | Jake Peavy | Ramon Ortiz | Trevor Hoffman | | 860 | 758 | 102 |