| 2006-04-03 | vs TBA | 1 | W 9-6 | 1-0 | 1 | 46,986 | Rodrigo Lopez | Scott Kazmir | Rodrigo Lopez | Scott Kazmir | Chris Ray | 9 | 6 | 3 |
| 2006-04-05 | vs TBA | 2 | W 16-6 | 2-0 | 1 | 16,083 | Erik Bedard | Seth McClung | Erik Bedard | Seth McClung | | 25 | 12 | 13 |
| 2006-04-06 | vs TBA | 3 | L 0-2 | 2-1 | 1 | 13,194 | Kris Benson | Mark Hendrickson | Mark Hendrickson | Kris Benson | | 25 | 14 | 11 |
| 2006-04-07 | vs BOS | 4 | L 8-14 | 2-2 | 2 | 37,063 | Daniel Cabrera | Matt Clement | Matt Clement | Daniel Cabrera | | 33 | 28 | 5 |
| 2006-04-08 | vs BOS | 5 | L 1-2 | 2-3 | 3 | 41,166 | Bruce Chen | Curt Schilling | Curt Schilling | Bruce Chen | Jonathan Papelbon | 34 | 30 | 4 |
| 2006-04-09 | vs BOS | 6 | L 1-4 | 2-4 | 4 | 37,998 | Rodrigo Lopez | Tim Wakefield | Tim Wakefield | Rodrigo Lopez | Jonathan Papelbon | 35 | 34 | 1 |
| 2006-04-10 | @ TBA | 7 | W 6-3 | 3-4 | 3 | 40,199 | Erik Bedard | Seth McClung | Erik Bedard | Seth McClung | Chris Ray | 41 | 37 | 4 |
| 2006-04-11 | @ TBA | 8 | W 8-4 | 4-4 | 2 | 12,600 | Kris Benson | Jason Hammel | Kris Benson | Jason Hammel | Chris Ray | 49 | 41 | 8 |
| 2006-04-12 | @ TBA | 9 | L 4-7 | 4-5 | 4 | 10,707 | Daniel Cabrera | Casey Fossum | Shawn Camp | Sendy Rleal | Dan Miceli | 53 | 48 | 5 |
| 2006-04-13 | @ TBA | 10 | W 6-5 | 5-5 | 4 | 13,042 | Bruce Chen | Doug Waechter | Chris Ray | Dan Miceli | | 59 | 53 | 6 |
| 2006-04-14 | vs ANA | 11 | W 6-5 | 6-5 | 3 | 25,415 | Rodrigo Lopez | Ervin Santana | Tim Byrdak | Scot Shields | | 65 | 58 | 7 |
| 2006-04-15 | vs ANA | 12 | W 3-2 | 7-5 | 2 | 24,497 | Erik Bedard | Bartolo Colon | Erik Bedard | Bartolo Colon | Chris Ray | 68 | 60 | 8 |
| 2006-04-16 | vs ANA | 13 | L 3-9 | 7-6 | 2 | 19,904 | Kris Benson | John Lackey | John Lackey | Kris Benson | | 71 | 69 | 2 |
| 2006-04-17 | vs ANA | 14 | W 4-2 | 8-6 | 2 | 15,691 | Daniel Cabrera | Jeff Weaver | Daniel Cabrera | Jeff Weaver | Chris Ray | 75 | 71 | 4 |
| 2006-04-18 | vs CLE | 15 | L 1-15 | 8-7 | 3 | 17,354 | Bruce Chen | Jason Johnson | Jason Johnson | Bruce Chen | | 76 | 86 | -10 |
| 2006-04-19 | vs CLE | 16 | W 18-9 | 9-7 | 2 | 19,510 | Rodrigo Lopez | Jake Westbrook | John Halama | Jake Westbrook | | 94 | 95 | -1 |
| 2006-04-20 | vs CLE | 17 | W 9-4 | 10-7 | 2 | 22,031 | Erik Bedard | Fausto Carmona | Erik Bedard | Fausto Carmona | | 103 | 99 | 4 |
| 2006-04-21 | @ NYA | 18 | W 6-5 | 11-7 | 2 | 51,282 | Kris Benson | Chien-Ming Wang | Kris Benson | Chien-Ming Wang | Chris Ray | 109 | 104 | 5 |
| 2006-04-22 | @ NYA | 19 | L 1-6 | 11-8 | 2 | 50,872 | Daniel Cabrera | Shawn Chacon | Shawn Chacon | Daniel Cabrera | | 110 | 110 | 0 |
| 2006-04-23 | @ NYA | 20 | L 1-7 | 11-9 | 2 | 47,996 | Bruce Chen | Randy Johnson | Randy Johnson | Bruce Chen | | 111 | 117 | -6 |
| 2006-04-25 | @ TOR | 21 | L 3-7 | 11-10 | 4 | 32,257 | Rodrigo Lopez | Gustavo Chacin | Gustavo Chacin | Rodrigo Lopez | | 114 | 124 | -10 |
| 2006-04-26 | @ TOR | 22 | L 2-8 | 11-11 | 4 | 19,336 | Erik Bedard | Ted Lilly | Ted Lilly | Erik Bedard | | 116 | 132 | -16 |
| 2006-04-27 | @ TOR | 23 | W 7-5 | 12-11 | 4 | 18,756 | Kris Benson | Casey Janssen | Kris Benson | Casey Janssen | | 123 | 137 | -14 |
| 2006-04-28 | vs SEA | 24 | W 5-2 | 13-11 | 3 | 26,934 | Daniel Cabrera | Gil Meche | Daniel Cabrera | Gil Meche | Chris Ray | 128 | 139 | -11 |
| 2006-04-29 | vs SEA | 25 | L 6-8 | 13-12 | 4 | 34,161 | Bruce Chen | Felix Hernandez | Felix Hernandez | Jim Brower | Eddie Guardado | 134 | 147 | -13 |
| 2006-04-30 | vs SEA | 26 | L 3-4 | 13-13 | 4 | 32,421 | Rodrigo Lopez | Jamie Moyer | Jamie Moyer | Rodrigo Lopez | Eddie Guardado | 137 | 151 | -14 |
| 2006-05-01 | vs TOR | 27 | L 7-9 | 13-14 | 4 | 14,315 | Erik Bedard | Ted Lilly | Ted Lilly | LaTroy Hawkins | B.J. Ryan | 144 | 160 | -16 |
| 2006-05-02 | vs TOR | 28 | W 9-2 | 14-14 | 4 | 15,795 | Kris Benson | Casey Janssen | Kris Benson | Casey Janssen | Todd Williams | 153 | 162 | -9 |
| 2006-05-03 | @ TEX | 29 | L 1-2 | 14-15 | 4 | 23,783 | Daniel Cabrera | John Koronka | Rick Bauer | John Halama | | 154 | 164 | -10 |
| 2006-05-04 | @ TEX | 30 | L 2-8 | 14-16 | 4 | 21,962 | Bruce Chen | Kevin Millwood | Kevin Millwood | Bruce Chen | | 156 | 172 | -16 |
| 2006-05-05 | @ BOS | 31 | L 3-6 | 14-17 | 4 | 36,515 | Rodrigo Lopez | Curt Schilling | Curt Schilling | Rodrigo Lopez | Jonathan Papelbon | 159 | 178 | -19 |
| 2006-05-06 | @ BOS | 32 | L 3-9 | 14-18 | 4 | 36,507 | Erik Bedard | Tim Wakefield | Tim Wakefield | Erik Bedard | | 162 | 187 | -25 |
| 2006-05-07 | @ BOS | 33 | L 3-10 | 14-19 | 4 | 36,022 | Kris Benson | Lenny DiNardo | Lenny DiNardo | Kris Benson | | 165 | 197 | -32 |
| 2006-05-09 | vs DET | 34 | W 7-6 | 15-19 | 4 | 16,566 | Daniel Cabrera | Nate Robertson | LaTroy Hawkins | Fernando Rodney | Chris Ray | 172 | 203 | -31 |
| 2006-05-10 | vs DET | 35 | L 3-6 | 15-20 | 4 | 15,548 | Rodrigo Lopez | Justin Verlander | Justin Verlander | Rodrigo Lopez | Todd Jones | 175 | 209 | -34 |
| 2006-05-12 | vs KCA | 36 | W 6-5 | 16-20 | 4 | 30,848 | Erik Bedard | Runelvys Hernandez | Todd Williams | Elmer Dessens | Chris Ray | 181 | 214 | -33 |
| 2006-05-13 | vs KCA | 37 | W 11-1 | 17-20 | 4 | 33,188 | Kris Benson | Mark Redman | Kris Benson | Mark Redman | | 192 | 215 | -23 |
| 2006-05-14 | vs KCA | 38 | W 8-7 | 18-20 | 4 | 25,530 | Daniel Cabrera | Denny Bautista | John Halama | Ambiorix Burgos | | 200 | 222 | -22 |
| 2006-05-15 | vs BOS | 39 | L 1-11 | 18-21 | 4 | 25,607 | Rodrigo Lopez | Josh Beckett | Josh Beckett | Rodrigo Lopez | | 201 | 233 | -32 |
| 2006-05-16 | vs BOS | 40 | L 5-6 | 18-22 | 4 | 27,565 | Bruce Chen | Curt Schilling | Curt Schilling | Todd Williams | Jonathan Papelbon | 206 | 239 | -33 |
| 2006-05-17 | vs BOS | 41 | W 4-3 | 19-22 | 4 | 32,089 | Erik Bedard | Tim Wakefield | Erik Bedard | Tim Wakefield | Chris Ray | 210 | 242 | -32 |
| 2006-05-19 | @ WAS | 42 | W 5-1 | 20-22 | 4 | 30,320 | Kris Benson | Mike O'Connor | Kris Benson | Mike O'Connor | | 215 | 243 | -28 |
| 2006-05-20 | @ WAS | 43 | L 3-8 | 20-23 | 4 | 32,502 | Rodrigo Lopez | Tony Armas | Jon Rauch | Rodrigo Lopez | | 218 | 251 | -33 |
| 2006-05-21 | @ WAS | 44 | L 1-3 | 20-24 | 4 | 32,152 | Bruce Chen | Livan Hernandez | Livan Hernandez | Bruce Chen | Chad Cordero | 219 | 254 | -35 |
| 2006-05-22 | @ SEA | 45 | L 6-8 | 20-25 | 4 | 18,819 | Erik Bedard | Jamie Moyer | Jamie Moyer | Erik Bedard | Eddie Guardado | 225 | 262 | -37 |
| 2006-05-23 | @ SEA | 46 | W 14-4 | 21-25 | 4 | 19,435 | John Halama | Joel Pineiro | John Halama | Joel Pineiro | Chris Ray | 239 | 266 | -27 |
| 2006-05-24 | @ SEA | 47 | L 4-7 | 21-26 | 4 | 21,991 | Kris Benson | Jarrod Washburn | Jarrod Washburn | Kris Benson | J.J. Putz | 243 | 273 | -30 |
| 2006-05-25 | @ SEA | 48 | W 2-0 | 22-26 | 4 | 23,806 | Rodrigo Lopez | Gil Meche | Rodrigo Lopez | Gil Meche | Chris Ray | 245 | 273 | -28 |
| 2006-05-26 | @ ANA | 49 | L 2-5 | 22-27 | 4 | 42,675 | Bruce Chen | Ervin Santana | Scot Shields | Todd Williams | Francisco Rodriguez | 247 | 278 | -31 |
| 2006-05-27 | @ ANA | 50 | L 1-10 | 22-28 | 4 | 43,005 | Erik Bedard | Jered Weaver | Jered Weaver | Erik Bedard | | 248 | 288 | -40 |
| 2006-05-28 | @ ANA | 51 | W 7-6 | 23-28 | 4 | 40,856 | Kris Benson | Kelvim Escobar | Kurt Birkins | Kelvim Escobar | Chris Ray | 255 | 294 | -39 |
| 2006-05-30 | vs TBA | 52 | W 7-5 | 24-28 | 4 | 15,505 | Rodrigo Lopez | Doug Waechter | Rodrigo Lopez | Doug Waechter | Chris Ray | 262 | 299 | -37 |
| 2006-05-31 | vs TBA | 53 | W 6-5 | 25-28 | 4 | 16,134 | Bruce Chen | James Shields | Sendy Rleal | Tyler Walker | | 268 | 304 | -36 |
| 2006-06-01 | vs TBA | 54 | L 6-8 | 25-29 | 4 | 14,044 | Erik Bedard | Scott Kazmir | Travis Harper | Erik Bedard | | 274 | 312 | -38 |
| 2006-06-02 | vs NYA | 55 | L 5-6 | 25-30 | 4 | 48,168 | Kris Benson | Jaret Wright | Kyle Farnsworth | Chris Ray | | 279 | 318 | -39 |
| 2006-06-03 | vs NYA | 56 | L 5-6 | 25-31 | 4 | 48,195 | Adam Loewen | Randy Johnson | Scott Proctor | Chris Ray | Chien-Ming Wang | 284 | 324 | -40 |
| 2006-06-04 | vs NYA | 57 | W 11-4 | 26-31 | 4 | 47,535 | Rodrigo Lopez | Aaron Small | Rodrigo Lopez | Aaron Small | | 295 | 328 | -33 |
| 2006-06-05 | vs TOR | 58 | W 4-0 | 27-31 | 4 | 15,185 | Daniel Cabrera | Ted Lilly | Daniel Cabrera | Ted Lilly | | 299 | 328 | -29 |
| 2006-06-06 | vs TOR | 59 | L 4-6 | 27-32 | 4 | 16,868 | Erik Bedard | Ty Taubenheim | Scott Downs | Chris Britton | B.J. Ryan | 303 | 334 | -31 |
| 2006-06-07 | vs TOR | 60 | L 3-5 | 27-33 | 4 | 15,803 | Kris Benson | Casey Janssen | Casey Janssen | Kris Benson | B.J. Ryan | 306 | 339 | -33 |
| 2006-06-08 | vs TOR | 61 | W 7-5 | 28-33 | 4 | 17,637 | Adam Loewen | Roy Halladay | Kurt Birkins | Francisco Rosario | Chris Ray | 313 | 344 | -31 |
| 2006-06-09 | @ MIN | 62 | L 5-7 | 28-34 | 4 | 22,894 | Rodrigo Lopez | Brad Radke | Joe Nathan | Bruce Chen | | 318 | 351 | -33 |
| 2006-06-10 | @ MIN | 63 | W 9-7 | 29-34 | 4 | 24,478 | Daniel Cabrera | Carlos Silva | Daniel Cabrera | Carlos Silva | | 327 | 358 | -31 |
| 2006-06-11 | @ MIN | 64 | L 0-4 | 29-35 | 4 | 25,438 | Erik Bedard | Francisco Liriano | Francisco Liriano | Erik Bedard | | 327 | 362 | -35 |
| 2006-06-12 | @ TOR | 65 | W 6-4 | 30-35 | 4 | 17,876 | Kris Benson | Casey Janssen | Kris Benson | Casey Janssen | Chris Ray | 333 | 366 | -33 |
| 2006-06-13 | @ TOR | 66 | L 1-7 | 30-36 | 4 | 20,766 | Adam Loewen | Roy Halladay | Roy Halladay | Adam Loewen | | 334 | 373 | -39 |
| 2006-06-14 | @ TOR | 67 | L 3-6 | 30-37 | 4 | 23,325 | Rodrigo Lopez | Scott Downs | Vinnie Chulk | Rodrigo Lopez | B.J. Ryan | 337 | 379 | -42 |
| 2006-06-15 | @ TOR | 68 | L 2-4 | 30-38 | 4 | 32,285 | Daniel Cabrera | Ted Lilly | Ted Lilly | Daniel Cabrera | B.J. Ryan | 339 | 383 | -44 |
| 2006-06-16 | @ NYN | 69 | W 6-3 | 31-38 | 4 | 45,967 | Erik Bedard | Alay Soler | Erik Bedard | Aaron Heilman | Chris Ray | 345 | 386 | -41 |
| 2006-06-17 | @ NYN | 70 | W 4-2 | 32-38 | 4 | 52,320 | Kris Benson | Pedro Martinez | Kris Benson | Pedro Martinez | Chris Ray | 349 | 388 | -39 |
| 2006-06-18 | @ NYN | 71 | L 4-9 | 32-39 | 4 | 43,393 | Adam Loewen | Tom Glavine | Tom Glavine | Adam Loewen | | 353 | 397 | -44 |
| 2006-06-20 | vs FLO | 72 | L 2-6 | 32-40 | 4 | 18,333 | Daniel Cabrera | Dontrelle Willis | Dontrelle Willis | Daniel Cabrera | Joe Borowski | 355 | 403 | -48 |
| 2006-06-21 | vs FLO | 73 | W 4-0 | 33-40 | 4 | 16,135 | Erik Bedard | Ricky Nolasco | Erik Bedard | Ricky Nolasco | | 359 | 403 | -44 |
| 2006-06-22 | vs FLO | 74 | L 5-8 | 33-41 | 4 | 20,081 | Kris Benson | Scott Olsen | Randy Messenger | Todd Williams | Joe Borowski | 364 | 411 | -47 |
| 2006-06-23 | vs WAS | 75 | W 2-1 | 34-41 | 4 | 48,331 | Rodrigo Lopez | John Patterson | Rodrigo Lopez | John Patterson | Chris Ray | 366 | 412 | -46 |
| 2006-06-24 | vs WAS | 76 | W 3-2 | 35-41 | 4 | 36,290 | Adam Loewen | Mike O'Connor | Todd Williams | Chad Cordero | | 369 | 414 | -45 |
| 2006-06-25 | vs WAS | 77 | L 5-9 | 35-42 | 4 | 27,680 | Daniel Cabrera | Livan Hernandez | Livan Hernandez | Daniel Cabrera | | 374 | 423 | -49 |
| 2006-06-28 | vs PHI | 78 | W 7-4 | 37-42 | 4 | 20,633 | Erik Bedard | Cole Hamels | Erik Bedard | Cole Hamels | Chris Ray | 381 | 427 | -46 |
| 2006-06-28 | vs PHI | 79 | W 12-5 | 37-42 | 4 | 26,228 | Kris Benson | Scott Mathieson | Kris Benson | Scott Mathieson | | 393 | 432 | -39 |
| 2006-06-29 | vs PHI | 80 | L 0-4 | 37-43 | 4 | 31,038 | Rodrigo Lopez | Ryan Madson | Ryan Madson | Rodrigo Lopez | Tom Gordon | 393 | 436 | -43 |
| 2006-06-30 | @ ATL | 81 | L 3-5 | 37-44 | 4 | 34,581 | Daniel Cabrera | Chuck James | Chuck James | Kurt Birkins | Jorge Sosa | 396 | 441 | -45 |
| 2006-07-01 | @ ATL | 82 | W 7-4 | 38-44 | 4 | 38,414 | Russ Ortiz | Tim Hudson | Kurt Birkins | Tim Hudson | | 403 | 445 | -42 |
| 2006-07-02 | @ ATL | 83 | L 3-10 | 38-45 | 4 | 27,693 | Kris Benson | Horacio Ramirez | Horacio Ramirez | Kris Benson | | 406 | 455 | -49 |
| 2006-07-03 | @ CHA | 84 | W 8-1 | 39-45 | 4 | 38,829 | Erik Bedard | Freddy Garcia | Erik Bedard | Freddy Garcia | | 414 | 456 | -42 |
| 2006-07-04 | @ CHA | 85 | L 0-13 | 39-46 | 4 | 37,300 | Rodrigo Lopez | Jose Contreras | Jose Contreras | Rodrigo Lopez | | 414 | 469 | -55 |
| 2006-07-05 | @ CHA | 86 | L 2-4 | 39-47 | 4 | 38,872 | Daniel Cabrera | Jon Garland | Jon Garland | Daniel Cabrera | Bobby Jenks | 416 | 473 | -57 |
| 2006-07-06 | @ CHA | 87 | L 8-11 | 39-48 | 4 | 35,266 | Russ Ortiz | Javier Vazquez | Javier Vazquez | Russ Ortiz | Matt Thornton | 424 | 484 | -60 |
| 2006-07-07 | @ CLE | 88 | L 0-9 | 39-49 | 4 | 27,110 | Kris Benson | CC Sabathia | CC Sabathia | Kris Benson | | 424 | 493 | -69 |
| 2006-07-08 | @ CLE | 89 | W 7-4 | 40-49 | 4 | 28,902 | Erik Bedard | Jeremy Sowers | Erik Bedard | Jeremy Sowers | Chris Ray | 431 | 497 | -66 |
| 2006-07-09 | @ CLE | 90 | W 5-4 | 41-49 | 4 | 26,452 | Rodrigo Lopez | Jake Westbrook | Kurt Birkins | Fausto Carmona | Chris Ray | 436 | 501 | -65 |
| 2006-07-13 | vs TEX | 91 | L 1-15 | 41-50 | 4 | 22,780 | Daniel Cabrera | Vicente Padilla | Vicente Padilla | Daniel Cabrera | | 437 | 516 | -79 |
| 2006-07-14 | vs TEX | 92 | L 1-2 | 41-51 | 4 | 28,201 | Kris Benson | Kevin Millwood | Kevin Millwood | Kris Benson | Akinori Otsuka | 438 | 518 | -80 |
| 2006-07-15 | vs TEX | 93 | W 8-1 | 42-51 | 4 | 35,804 | Erik Bedard | John Rheinecker | Erik Bedard | John Rheinecker | | 446 | 519 | -73 |
| 2006-07-16 | vs TEX | 94 | W 4-0 | 43-51 | 4 | 25,169 | Rodrigo Lopez | John Wasdin | Rodrigo Lopez | John Wasdin | | 450 | 519 | -69 |
| 2006-07-17 | vs OAK | 95 | W 5-3 | 44-51 | 4 | 19,652 | Adam Loewen | Jason Windsor | Kurt Birkins | Kirk Saarloos | Chris Ray | 455 | 522 | -67 |
| 2006-07-18 | vs OAK | 96 | L 4-5 | 44-52 | 4 | 20,827 | Russ Ortiz | Esteban Loaiza | Esteban Loaiza | Eddy Rodriguez | Huston Street | 459 | 527 | -68 |
| 2006-07-19 | vs OAK | 97 | L 1-5 | 44-53 | 4 | 29,407 | Kris Benson | Barry Zito | Barry Zito | Kris Benson | | 460 | 532 | -72 |
| 2006-07-21 | @ TBA | 98 | L 7-14 | 44-54 | 4 | 17,759 | Russ Ortiz | Casey Fossum | Casey Fossum | Russ Ortiz | | 467 | 546 | -79 |
| 2006-07-22 | @ TBA | 99 | L 12-13 | 44-55 | 4 | 17,347 | Rodrigo Lopez | Tim Corcoran | Shawn Camp | Rodrigo Lopez | Brian Meadows | 479 | 559 | -80 |
| 2006-07-23 | @ TBA | 100 | W 4-2 | 45-55 | 4 | 23,747 | Erik Bedard | Scott Kazmir | Erik Bedard | Jon Switzer | Chris Ray | 483 | 561 | -78 |
| 2006-07-25 | @ KCA | 101 | L 5-7 | 45-56 | 4 | 18,591 | Kris Benson | Mark Redman | Mark Redman | Kurt Birkins | Ambiorix Burgos | 488 | 568 | -80 |
| 2006-07-26 | @ KCA | 102 | W 4-3 | 46-56 | 4 | 11,006 | Adam Loewen | Runelvys Hernandez | Adam Loewen | Runelvys Hernandez | Chris Ray | 492 | 571 | -79 |
| 2006-07-27 | @ KCA | 103 | W 6-4 | 47-56 | 4 | 11,418 | Rodrigo Lopez | Jimmy Gobble | Rodrigo Lopez | Brandon Duckworth | Chris Ray | 498 | 575 | -77 |
| 2006-07-28 | vs CHA | 104 | L 4-6 | 47-57 | 4 | 35,382 | Erik Bedard | Freddy Garcia | Matt Thornton | Chris Ray | Bobby Jenks | 502 | 581 | -79 |
| 2006-07-29 | vs CHA | 105 | L 11-13 | 47-58 | 4 | 34,598 | Jim Johnson | Jon Garland | Jon Garland | Jim Johnson | Bobby Jenks | 513 | 594 | -81 |
| 2006-07-30 | vs CHA | 106 | W 8-7 | 48-58 | 4 | 28,725 | Bruce Chen | Javier Vazquez | Eddy Rodriguez | Bobby Jenks | | 521 | 601 | -80 |
| 2006-07-31 | vs SEA | 107 | L 5-10 | 48-59 | 4 | 16,620 | Adam Loewen | Gil Meche | Julio Mateo | Adam Loewen | | 526 | 611 | -85 |
| 2006-08-01 | vs SEA | 108 | W 2-0 | 49-59 | 4 | 20,226 | Rodrigo Lopez | Jamie Moyer | Rodrigo Lopez | Jamie Moyer | Chris Ray | 528 | 611 | -83 |
| 2006-08-02 | vs SEA | 109 | L 1-2 | 49-60 | 4 | 17,682 | Erik Bedard | Felix Hernandez | Felix Hernandez | Erik Bedard | J.J. Putz | 529 | 613 | -84 |
| 2006-08-04 | vs NYA | 110 | L 4-5 | 49-61 | 4 | 44,840 | Bruce Chen | Randy Johnson | Scott Proctor | Chris Ray | Mariano Rivera | 533 | 618 | -85 |
| 2006-08-05 | vs NYA | 111 | W 5-0 | 50-61 | 4 | 49,159 | Adam Loewen | Mike Mussina | Adam Loewen | Mike Mussina | | 538 | 618 | -80 |
| 2006-08-06 | vs NYA | 112 | L 1-6 | 50-62 | 4 | 45,693 | Rodrigo Lopez | Jaret Wright | Jaret Wright | Rodrigo Lopez | Mariano Rivera | 539 | 624 | -85 |
| 2006-08-07 | @ TOR | 113 | L 1-8 | 50-63 | 4 | 23,838 | Russ Ortiz | Brian Tallet | Jeremy Accardo | Russ Ortiz | Brandon League | 540 | 632 | -92 |
| 2006-08-08 | @ TOR | 114 | W 8-4 | 51-63 | 4 | 28,823 | Daniel Cabrera | Shaun Marcum | Daniel Cabrera | Scott Schoeneweis | | 548 | 636 | -88 |
| 2006-08-09 | @ TOR | 115 | L 3-4 | 51-64 | 4 | 34,199 | Erik Bedard | Roy Halladay | Roy Halladay | Erik Bedard | B.J. Ryan | 551 | 640 | -89 |
| 2006-08-11 | @ BOS | 116 | L 2-9 | 51-65 | 4 | 36,191 | Adam Loewen | David Wells | David Wells | Adam Loewen | | 553 | 649 | -96 |
| 2006-08-12 | @ BOS | 117 | L 7-8 | 51-66 | 4 | 35,768 | Kris Benson | Jason Johnson | Jonathan Papelbon | Bruce Chen | | 560 | 657 | -97 |
| 2006-08-13 | @ BOS | 118 | L 9-11 | 51-67 | 4 | 35,744 | Daniel Cabrera | Jon Lester | Jon Lester | Daniel Cabrera | Jonathan Papelbon | 569 | 668 | -99 |
| 2006-08-15 | @ NYA | 119 | L 3-6 | 51-68 | 4 | 52,418 | Erik Bedard | Mike Mussina | Scott Proctor | LaTroy Hawkins | Mariano Rivera | 572 | 674 | -102 |
| 2006-08-16 | @ NYA | 120 | W 3-2 | 52-68 | 4 | 54,244 | Adam Loewen | Cory Lidle | Adam Loewen | Cory Lidle | Chris Ray | 575 | 676 | -101 |
| 2006-08-17 | @ NYA | 121 | W 12-2 | 53-68 | 4 | 54,333 | Rodrigo Lopez | Jaret Wright | Rodrigo Lopez | Jaret Wright | | 587 | 678 | -91 |
| 2006-08-18 | vs TOR | 122 | W 7-2 | 54-68 | 4 | 22,679 | Kris Benson | Scott Downs | Kris Benson | Scott Downs | | 594 | 680 | -86 |
| 2006-08-19 | vs TOR | 123 | W 15-0 | 55-68 | 4 | 25,380 | Daniel Cabrera | Shaun Marcum | Daniel Cabrera | Shaun Marcum | | 609 | 680 | -71 |
| 2006-08-20 | vs TOR | 124 | L 2-9 | 55-69 | 4 | 23,639 | Erik Bedard | Roy Halladay | Roy Halladay | Erik Bedard | | 611 | 689 | -78 |
| 2006-08-22 | vs MIN | 125 | W 6-3 | 56-69 | 4 | 19,756 | Adam Loewen | Carlos Silva | Adam Loewen | Carlos Silva | Chris Ray | 617 | 692 | -75 |
| 2006-08-23 | vs MIN | 126 | L 1-4 | 56-70 | 4 | 19,258 | Rodrigo Lopez | Matt Garza | Matt Garza | Rodrigo Lopez | Joe Nathan | 618 | 696 | -78 |
| 2006-08-24 | vs MIN | 127 | L 2-11 | 56-71 | 4 | 24,848 | Kris Benson | Boof Bonser | Boof Bonser | Kris Benson | | 620 | 707 | -87 |
| 2006-08-25 | vs TBA | 128 | W 4-0 | 57-71 | 4 | 25,510 | Daniel Cabrera | Jason Hammel | Daniel Cabrera | Jason Hammel | Chris Ray | 624 | 707 | -83 |
| 2006-08-26 | vs TBA | 129 | W 3-2 | 58-71 | 4 | 26,379 | Erik Bedard | James Shields | Chris Ray | Shawn Camp | | 627 | 709 | -82 |
| 2006-08-27 | vs TBA | 130 | W 5-4 | 59-71 | 4 | 21,301 | Adam Loewen | J.P. Howell | LaTroy Hawkins | Seth McClung | | 632 | 713 | -81 |
| 2006-08-29 | @ TEX | 131 | L 4-9 | 59-72 | 4 | 23,684 | Rodrigo Lopez | Kevin Millwood | Kevin Millwood | Rodrigo Lopez | | 636 | 722 | -86 |
| 2006-08-30 | @ TEX | 132 | W 7-4 | 60-72 | 4 | 23,812 | Kris Benson | Rob Tejeda | LaTroy Hawkins | Ron Mahay | | 643 | 726 | -83 |
| 2006-08-31 | @ TEX | 133 | L 5-7 | 60-73 | 4 | 21,446 | Daniel Cabrera | Adam Eaton | Adam Eaton | Daniel Cabrera | Akinori Otsuka | 648 | 733 | -85 |
| 2006-09-01 | @ OAK | 134 | L 4-5 | 60-74 | 4 | 31,179 | Erik Bedard | Joe Blanton | Brad Halsey | Todd Williams | Justin Duchscherer | 652 | 738 | -86 |
| 2006-09-02 | @ OAK | 135 | W 6-5 | 61-74 | 4 | 24,383 | Adam Loewen | Dan Haren | Adam Loewen | Dan Haren | Chris Ray | 658 | 743 | -85 |
| 2006-09-03 | @ OAK | 136 | L 1-10 | 61-75 | 4 | 26,280 | Hayden Penn | Esteban Loaiza | Esteban Loaiza | Hayden Penn | | 659 | 753 | -94 |
| 2006-09-04 | @ ANA | 137 | L 0-1 | 61-76 | 4 | 38,217 | Rodrigo Lopez | Jered Weaver | Jered Weaver | Rodrigo Lopez | Francisco Rodriguez | 659 | 754 | -95 |
| 2006-09-05 | @ ANA | 138 | L 2-5 | 61-77 | 4 | 43,658 | Kris Benson | John Lackey | Brendan Donnelly | Julio Manon | | 661 | 759 | -98 |
| 2006-09-06 | @ ANA | 139 | L 4-8 | 61-78 | 4 | 33,736 | Daniel Cabrera | Ervin Santana | Ervin Santana | Chris Britton | | 665 | 767 | -102 |
| 2006-09-08 | vs NYA | 140 | W 9-4 | 62-78 | 4 | 36,214 | Erik Bedard | Cory Lidle | Erik Bedard | Cory Lidle | | 674 | 771 | -97 |
| 2006-09-09 | vs NYA | 141 | L 2-3 | 62-79 | 4 | 45,827 | Adam Loewen | Chien-Ming Wang | Chien-Ming Wang | Adam Loewen | Kyle Farnsworth | 676 | 774 | -98 |
| 2006-09-10 | vs NYA | 142 | L 4-9 | 62-80 | 4 | 40,125 | Hayden Penn | Jaret Wright | Jaret Wright | Hayden Penn | | 680 | 783 | -103 |
| 2006-09-11 | vs NYA | 143 | L 6-9 | 62-81 | 4 | 21,742 | Rodrigo Lopez | Randy Johnson | Randy Johnson | Jim Hoey | Kyle Farnsworth | 686 | 792 | -106 |
| 2006-09-12 | vs BOS | 144 | L 5-6 | 62-82 | 4 | 24,551 | Daniel Cabrera | Kason Gabbard | Craig Hansen | Daniel Cabrera | Javier Lopez | 691 | 798 | -107 |
| 2006-09-13 | vs BOS | 145 | W 4-0 | 63-82 | 4 | 22,240 | Erik Bedard | Tim Wakefield | Erik Bedard | Tim Wakefield | | 695 | 798 | -103 |
| 2006-09-14 | vs BOS | 146 | L 5-6 | 63-83 | 4 | 27,741 | Adam Loewen | Lenny DiNardo | Keith Foulke | Rodrigo Lopez | Mike Timlin | 700 | 804 | -104 |
| 2006-09-15 | @ DET | 147 | L 2-17 | 63-84 | 4 | 38,261 | Hayden Penn | Jeremy Bonderman | Jeremy Bonderman | Hayden Penn | | 702 | 821 | -119 |
| 2006-09-16 | @ DET | 148 | L 0-2 | 63-85 | 4 | 39,030 | Kris Benson | Nate Robertson | Nate Robertson | Kris Benson | Todd Jones | 702 | 823 | -121 |
| 2006-09-17 | @ DET | 149 | W 12-8 | 64-85 | 4 | 37,464 | Daniel Cabrera | Wil Ledezma | Chris Ray | Jason Grilli | | 714 | 831 | -117 |
| 2006-09-18 | @ TBA | 150 | W 4-1 | 65-85 | 4 | 11,729 | Erik Bedard | Tim Corcoran | Erik Bedard | Tim Corcoran | Chris Ray | 718 | 832 | -114 |
| 2006-09-19 | @ TBA | 151 | W 5-4 | 66-85 | 4 | 9,292 | Adam Loewen | Jason Hammel | Adam Loewen | Jason Hammel | Chris Britton | 723 | 836 | -113 |
| 2006-09-20 | @ TBA | 152 | L 2-4 | 66-86 | 4 | 10,818 | Hayden Penn | Jae Weong Seo | Seth McClung | Rodrigo Lopez | | 725 | 840 | -115 |
| 2006-09-21 | vs DET | 153 | W 4-3 | 67-86 | 4 | 17,877 | Kris Benson | Nate Robertson | Kris Benson | Fernando Rodney | Chris Ray | 729 | 843 | -114 |
| 2006-09-22 | vs MIN | 154 | W 7-3 | 68-86 | 4 | 21,051 | Daniel Cabrera | Carlos Silva | Daniel Cabrera | Carlos Silva | | 736 | 846 | -110 |
| 2006-09-23 | vs MIN | 155 | L 5-8 | 68-87 | 4 | 21,980 | Erik Bedard | Scott Baker | Matt Guerrier | Erik Bedard | Joe Nathan | 741 | 854 | -113 |
| 2006-09-24 | vs MIN | 156 | L 3-6 | 68-88 | 4 | 23,005 | Adam Loewen | Matt Garza | Matt Garza | Adam Loewen | Joe Nathan | 744 | 860 | -116 |
| 2006-09-26 | @ NYA | 157 | L 4-5 | 68-89 | 4 | 53,420 | Hayden Penn | Cory Lidle | Cory Lidle | Rodrigo Lopez | Scott Proctor | 748 | 865 | -117 |
| 2006-09-27 | @ NYA | 158 | L 5-16 | 68-90 | 4 | 53,040 | Kris Benson | Chien-Ming Wang | Chien-Ming Wang | Kris Benson | | 753 | 881 | -128 |
| 2006-09-28 | @ NYA | 159 | W 7-1 | 69-90 | 4 | 54,046 | Daniel Cabrera | Darrell Rasner | Daniel Cabrera | Darrell Rasner | | 760 | 882 | -122 |
| 2006-09-29 | @ BOS | 160 | L 3-4 | 69-91 | 4 | 36,269 | Erik Bedard | Julian Tavarez | Julian Tavarez | Erik Bedard | Mike Timlin | 763 | 886 | -123 |
| 2006-09-30 | @ BOS | 161 | W 5-4 | 70-91 | 4 | 36,596 | Adam Loewen | Tim Wakefield | Chris Ray | Mike Timlin | | 768 | 890 | -122 |
| 2006-10-01 | @ BOS | 162 | L 0-9 | 70-92 | 4 | 35,826 | Hayden Penn | Devern Hansack | Devern Hansack | Hayden Penn | | 768 | 899 | -131 |