| West | W | L | Pct | GB |
| Oakland | 93 | 69 | .574 | -- |
| LA Angels | 89 | 73 | .549 | 4.0 |
| Texas | 80 | 82 | .494 | 13.0 |
| Seattle | 78 | 84 | .481 | 15.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2006-04-03 | Jamie Moyer | L | 43 | W 4-5 | vs ANA | 1 | 486 | - | 6.2 | 9 | 3 | 3 | 1 | 1 | 2 | 79 | 28 | 51 | 65% | 0-0 | 3.86 | 1.43 |
| 2006-04-04 | Joel Pineiro | R | 28 | L 10-8 | vs ANA | 1 | 124 | W | 6.1 | 7 | 3 | 3 | 1 | 2 | 2 | 97 | 32 | 65 | 67% | 1-0 | 4.50 | 1.50 |
| 2006-04-05 | Jarrod Washburn | L | 32 | L 6-4 | vs ANA | 1 | 184 | W | 7.0 | 6 | 2 | 2 | 1 | 0 | 7 | 97 | 36 | 61 | 63% | 1-0 | 2.57 | 0.86 |
| 2006-04-06 | Gil Meche | R | 28 | L 6-2 | vs OAK | 1 | 112 | W | 5.1 | 4 | 2 | 2 | 1 | 2 | 6 | 98 | 40 | 58 | 59% | 1-0 | 3.60 | 1.20 |
| 2006-04-07 | Felix Hernandez | R | 20 | W 0-5 | vs OAK | 1 | 13 | L | 5.0 | 2 | 1 | 1 | 0 | 4 | 4 | 100 | 44 | 56 | 56% | 0-1 | 1.80 | 1.20 |
| 2006-04-08 | Jamie Moyer | L | 43 | W 0-3 | vs OAK | 2 | 487 | L | 5.2 | 6 | 3 | 3 | 1 | 1 | 4 | 100 | 43 | 57 | 57% | 0-1 | 4.50 | 1.42 |
| 2006-04-09 | Joel Pineiro | R | 28 | W 4-6 | vs OAK | 2 | 125 | L | 7.0 | 10 | 6 | 5 | 1 | 1 | 5 | 115 | 45 | 70 | 61% | 1-1 | 5.54 | 1.54 |
| 2006-04-11 | Jarrod Washburn | L | 32 | L 5-9 | @ CLE | 2 | 185 | L | 5.0 | 9 | 6 | 6 | 2 | 1 | 0 | 72 | 27 | 45 | 63% | 1-1 | 6.00 | 1.33 |
| 2006-04-12 | Gil Meche | R | 28 | W 11-9 | @ CLE | 2 | 113 | - | 4.0 | 7 | 5 | 5 | 0 | 4 | 1 | 86 | 38 | 48 | 56% | 1-0 | 7.00 | 1.89 |
| 2006-04-13 | Felix Hernandez | R | 20 | W 9-5 | @ CLE | 2 | 14 | - | 4.2 | 7 | 5 | 5 | 2 | 4 | 4 | 105 | 44 | 61 | 58% | 0-1 | 5.40 | 1.70 |
| 2006-04-14 | Jamie Moyer | L | 43 | L 1-2 | @ BOS | 3 | 488 | L | 6.0 | 8 | 2 | 2 | 0 | 3 | 8 | 114 | 45 | 69 | 61% | 0-2 | 4.00 | 1.56 |
| 2006-04-15 | Joel Pineiro | R | 28 | W 3-0 | @ BOS | 3 | 126 | W | 6.1 | 5 | 0 | 0 | 0 | 2 | 5 | 111 | 40 | 71 | 64% | 2-1 | 3.60 | 1.35 |
| 2006-04-16 | Jarrod Washburn | L | 32 | L 2-3 | @ BOS | 3 | 186 | L | 6.0 | 3 | 3 | 2 | 0 | 4 | 5 | 120 | 47 | 73 | 61% | 1-2 | 5.00 | 1.28 |
| 2006-04-17 | Gil Meche | R | 28 | L 6-7 | @ BOS | 3 | 114 | - | 6.0 | 8 | 4 | 4 | 2 | 1 | 3 | 102 | 39 | 63 | 62% | 1-0 | 6.60 | 1.73 |
| 2006-04-18 | Felix Hernandez | R | 20 | W 4-7 | vs TEX | 3 | 15 | L | 5.0 | 6 | 4 | 4 | 2 | 1 | 9 | 98 | 35 | 63 | 64% | 0-2 | 6.00 | 1.60 |
| 2006-04-19 | Jamie Moyer | L | 43 | L 9-6 | vs TEX | 4 | 489 | - | 6.0 | 8 | 4 | 3 | 0 | 2 | 2 | 106 | 40 | 66 | 62% | 0-2 | 4.13 | 1.58 |
| 2006-04-20 | Joel Pineiro | R | 28 | W 3-4 | vs TEX | 4 | 127 | - | 5.1 | 4 | 3 | 3 | 1 | 4 | 3 | 103 | 45 | 58 | 56% | 2-1 | 3.96 | 1.40 |
| 2006-04-21 | Jarrod Washburn | L | 32 | W 1-2 | vs DET | 4 | 187 | L | 8.2 | 5 | 2 | 2 | 1 | 0 | 2 | 120 | 36 | 84 | 70% | 1-3 | 4.00 | 1.04 |
| 2006-04-22 | Gil Meche | R | 28 | W 0-2 | vs DET | 4 | 115 | L | 6.0 | 6 | 1 | 1 | 0 | 3 | 7 | 121 | 47 | 74 | 61% | 1-1 | 5.14 | 1.67 |
| 2006-04-23 | Felix Hernandez | R | 20 | W 4-6 | vs DET | 4 | 16 | L | 7.0 | 6 | 3 | 1 | 0 | 1 | 9 | 98 | 30 | 68 | 69% | 0-3 | 4.50 | 1.41 |
| 2006-04-24 | Jamie Moyer | L | 43 | L 4-3 | vs CHA | 5 | 490 | - | 7.0 | 5 | 2 | 1 | 0 | 1 | 5 | 109 | 36 | 73 | 67% | 0-2 | 3.48 | 1.42 |
| 2006-04-25 | Joel Pineiro | R | 28 | W 3-13 | vs CHA | 5 | 128 | L | 4.0 | 6 | 5 | 5 | 2 | 2 | 2 | 81 | 37 | 44 | 54% | 2-2 | 4.97 | 1.48 |
| 2006-04-26 | Jarrod Washburn | L | 32 | L 5-1 | vs CHA | 5 | 188 | W | 6.2 | 4 | 1 | 1 | 0 | 1 | 4 | 106 | 42 | 64 | 60% | 2-3 | 3.55 | 1.00 |
| 2006-04-28 | Gil Meche | R | 28 | L 2-5 | @ BAL | 5 | 116 | L | 5.0 | 8 | 4 | 2 | 1 | 3 | 3 | 85 | 36 | 49 | 58% | 1-2 | 4.85 | 1.77 |
| 2006-04-29 | Felix Hernandez | R | 20 | W 8-6 | @ BAL | 5 | 17 | W | 5.0 | 10 | 4 | 4 | 1 | 2 | 2 | 92 | 32 | 60 | 65% | 1-3 | 5.00 | 1.59 |
| 2006-04-30 | Jamie Moyer | L | 43 | W 4-3 | @ BAL | 6 | 491 | W | 6.2 | 6 | 3 | 3 | 2 | 2 | 1 | 94 | 34 | 60 | 64% | 1-2 | 3.55 | 1.37 |
| 2006-05-01 | Joel Pineiro | R | 28 | W 8-2 | @ MIN | 6 | 129 | W | 9.0 | 9 | 2 | 2 | 1 | 0 | 0 | 106 | 29 | 77 | 73% | 3-2 | 4.26 | 1.37 |
| 2006-05-02 | Jarrod Washburn | L | 32 | L 1-5 | @ MIN | 6 | 189 | L | 7.0 | 7 | 4 | 4 | 0 | 0 | 3 | 95 | 34 | 61 | 64% | 2-4 | 3.83 | 1.00 |
| 2006-05-03 | Gil Meche | R | 28 | L 5-6 | @ CHA | 6 | 117 | - | 6.0 | 3 | 3 | 3 | 0 | 4 | 1 | 98 | 49 | 49 | 50% | 1-2 | 4.78 | 1.66 |
| 2006-05-04 | Felix Hernandez | R | 20 | L 1-4 | @ CHA | 6 | 18 | L | 5.0 | 7 | 4 | 4 | 1 | 2 | 7 | 94 | 38 | 56 | 60% | 1-4 | 5.34 | 1.63 |
| 2006-05-05 | Jamie Moyer | L | 43 | W 4-9 | vs CLE | 7 | 492 | - | 6.0 | 6 | 3 | 3 | 2 | 1 | 4 | 94 | 37 | 57 | 61% | 1-2 | 3.68 | 1.34 |
| 2006-05-06 | Joel Pineiro | R | 28 | L 4-1 | vs CLE | 7 | 130 | W | 8.0 | 4 | 1 | 1 | 1 | 0 | 6 | 100 | 31 | 69 | 69% | 4-2 | 3.72 | 1.22 |
| 2006-05-07 | Jarrod Washburn | L | 32 | W 0-2 | vs CLE | 7 | 190 | L | 7.0 | 4 | 2 | 2 | 0 | 2 | 2 | 109 | 43 | 66 | 61% | 2-5 | 3.64 | 0.98 |
| 2006-05-08 | Gil Meche | R | 28 | L 6-3 | vs TBA | 7 | 118 | W | 7.0 | 6 | 3 | 3 | 1 | 3 | 6 | 112 | 44 | 68 | 61% | 2-2 | 4.62 | 1.59 |
| 2006-05-09 | Felix Hernandez | R | 20 | L 8-1 | vs TBA | 7 | 19 | W | 7.2 | 5 | 1 | 1 | 0 | 2 | 8 | 108 | 40 | 68 | 63% | 2-4 | 4.62 | 1.51 |
| 2006-05-10 | Jamie Moyer | L | 44 | W 0-1 | vs TBA | 8 | 493 | L | 8.0 | 4 | 1 | 1 | 0 | 0 | 5 | 114 | 36 | 78 | 68% | 1-3 | 3.29 | 1.21 |
| 2006-05-12 | Joel Pineiro | R | 28 | L 7-12 | @ ANA | 8 | 131 | L | 3.0 | 6 | 6 | 6 | 1 | 3 | 1 | 74 | 30 | 44 | 59% | 4-3 | 4.59 | 1.33 |
| 2006-05-13 | Jarrod Washburn | L | 32 | W 5-4 | @ ANA | 8 | 191 | - | 5.2 | 9 | 4 | 4 | 1 | 1 | 0 | 105 | 33 | 72 | 69% | 2-5 | 3.91 | 1.06 |
| 2006-05-14 | Gil Meche | R | 28 | W 9-4 | @ ANA | 8 | 119 | W | 5.1 | 6 | 4 | 4 | 1 | 3 | 5 | 113 | 49 | 64 | 57% | 3-2 | 4.80 | 1.58 |
| 2006-05-16 | Felix Hernandez | R | 20 | L 6-12 | @ OAK | 8 | 20 | L | 4.0 | 11 | 10 | 5 | 2 | 2 | 4 | 90 | 33 | 57 | 63% | 2-5 | 5.23 | 1.67 |
| 2006-05-17 | Jamie Moyer | L | 44 | L 2-7 | @ OAK | 9 | 494 | L | 6.0 | 11 | 7 | 5 | 0 | 3 | 4 | 110 | 46 | 64 | 58% | 1-4 | 3.72 | 1.33 |
| 2006-05-18 | Joel Pineiro | R | 28 | L 3-6 | @ OAK | 9 | 132 | L | 6.0 | 7 | 6 | 5 | 0 | 2 | 1 | 109 | 42 | 67 | 61% | 4-4 | 4.91 | 1.35 |
| 2006-05-19 | Jarrod Washburn | L | 32 | L 7-4 | vs SDN | 9 | 192 | - | 6.0 | 5 | 2 | 2 | 1 | 2 | 3 | 101 | 47 | 54 | 53% | 2-5 | 3.81 | 1.07 |
| 2006-05-20 | Gil Meche | R | 28 | L 6-3 | vs SDN | 9 | 120 | W | 7.2 | 5 | 3 | 3 | 1 | 1 | 7 | 108 | 36 | 72 | 67% | 4-2 | 4.67 | 1.48 |
| 2006-05-21 | Felix Hernandez | R | 20 | L 10-8 | vs SDN | 9 | 21 | W | 6.0 | 7 | 7 | 7 | 1 | 3 | 4 | 103 | 38 | 65 | 63% | 3-5 | 5.88 | 1.67 |
| 2006-05-22 | Jamie Moyer | L | 44 | L 8-6 | vs BAL | 10 | 495 | W | 6.0 | 7 | 2 | 2 | 0 | 4 | 4 | 110 | 46 | 64 | 58% | 2-4 | 3.66 | 1.38 |
| 2006-05-23 | Joel Pineiro | R | 28 | W 4-14 | vs BAL | 10 | 133 | L | 5.0 | 10 | 5 | 5 | 2 | 3 | 2 | 98 | 41 | 57 | 58% | 4-5 | 5.25 | 1.45 |
| 2006-05-24 | Jarrod Washburn | L | 32 | L 7-4 | vs BAL | 10 | 193 | W | 5.2 | 7 | 4 | 4 | 2 | 4 | 2 | 104 | 46 | 58 | 56% | 3-5 | 4.02 | 1.14 |
| 2006-05-25 | Gil Meche | R | 28 | W 0-2 | vs BAL | 10 | 121 | L | 7.0 | 4 | 2 | 2 | 0 | 2 | 10 | 114 | 45 | 69 | 61% | 4-3 | 4.42 | 1.41 |
| 2006-05-26 | Felix Hernandez | R | 20 | L 1-3 | @ MIN | 10 | 22 | L | 7.0 | 5 | 3 | 3 | 1 | 1 | 8 | 103 | 30 | 73 | 71% | 3-6 | 5.63 | 1.57 |
| 2006-05-27 | Jamie Moyer | L | 44 | L 5-9 | @ MIN | 11 | 496 | L | 6.0 | 11 | 8 | 7 | 2 | 0 | 2 | 104 | 36 | 68 | 65% | 2-5 | 4.24 | 1.41 |
| 2006-05-28 | Joel Pineiro | R | 28 | L 3-4 | @ MIN | 11 | 134 | - | 6.2 | 9 | 3 | 3 | 1 | 2 | 2 | 100 | 35 | 65 | 65% | 4-5 | 5.10 | 1.46 |
| 2006-05-29 | Jarrod Washburn | L | 32 | L 0-2 | @ TEX | 11 | 194 | L | 7.0 | 6 | 2 | 2 | 1 | 0 | 5 | 105 | 36 | 69 | 66% | 3-6 | 3.88 | 1.11 |
| 2006-05-30 | Gil Meche | R | 28 | L 4-6 | @ TEX | 11 | 122 | L | 5.1 | 9 | 6 | 6 | 2 | 5 | 4 | 114 | 52 | 62 | 54% | 4-4 | 4.85 | 1.49 |
| 2006-05-31 | Felix Hernandez | R | 20 | W 14-5 | @ TEX | 11 | 23 | W | 6.0 | 7 | 5 | 5 | 1 | 1 | 4 | 95 | 37 | 58 | 61% | 4-6 | 5.81 | 1.55 |
| 2006-06-02 | Jamie Moyer | L | 44 | L 4-0 | vs KCA | 12 | 497 | W | 9.0 | 2 | 0 | 0 | 0 | 1 | 2 | 93 | 36 | 57 | 61% | 3-5 | 3.76 | 1.29 |
| 2006-06-03 | Joel Pineiro | R | 28 | L 12-1 | vs KCA | 12 | 135 | W | 7.0 | 7 | 1 | 1 | 0 | 2 | 4 | 101 | 35 | 66 | 65% | 5-5 | 4.74 | 1.45 |
| 2006-06-04 | Jarrod Washburn | L | 32 | W 4-9 | vs KCA | 12 | 195 | L | 4.1 | 8 | 7 | 7 | 2 | 2 | 5 | 98 | 38 | 60 | 61% | 3-7 | 4.50 | 1.18 |
| 2006-06-05 | Gil Meche | R | 28 | L 4-1 | vs KCA | 12 | 123 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 6 | 95 | 36 | 59 | 62% | 5-4 | 4.50 | 1.43 |
| 2006-06-06 | Felix Hernandez | R | 20 | L 4-2 | vs MIN | 12 | 24 | W | 7.0 | 6 | 1 | 1 | 0 | 2 | 5 | 99 | 40 | 59 | 60% | 5-6 | 5.35 | 1.51 |
| 2006-06-07 | Jamie Moyer | L | 44 | L 10-9 | vs MIN | 13 | 498 | - | 5.0 | 10 | 4 | 3 | 0 | 2 | 1 | 89 | 36 | 53 | 60% | 3-5 | 3.86 | 1.36 |
| 2006-06-08 | Joel Pineiro | R | 28 | W 3-7 | vs MIN | 13 | 136 | L | 5.1 | 9 | 7 | 6 | 0 | 6 | 2 | 105 | 44 | 61 | 58% | 5-6 | 5.13 | 1.54 |
| 2006-06-09 | Jarrod Washburn | L | 32 | W 4-1 | @ ANA | 13 | 196 | W | 6.0 | 6 | 1 | 1 | 0 | 1 | 4 | 105 | 43 | 62 | 59% | 4-7 | 4.28 | 1.18 |
| 2006-06-10 | Gil Meche | R | 28 | W 12-6 | @ ANA | 13 | 124 | W | 5.0 | 7 | 2 | 2 | 0 | 4 | 3 | 102 | 43 | 59 | 58% | 6-4 | 4.44 | 1.48 |
| 2006-06-11 | Felix Hernandez | R | 20 | W 6-2 | @ ANA | 13 | 25 | W | 9.0 | 4 | 2 | 2 | 0 | 0 | 9 | 95 | 22 | 73 | 77% | 6-6 | 4.96 | 1.38 |
| 2006-06-13 | Jamie Moyer | L | 44 | L 0-2 | @ OAK | 14 | 499 | L | 6.0 | 8 | 2 | 2 | 1 | 2 | 4 | 100 | 38 | 62 | 62% | 3-6 | 3.80 | 1.38 |
| 2006-06-14 | Joel Pineiro | R | 28 | L 2-7 | @ OAK | 14 | 137 | L | 4.0 | 6 | 7 | 5 | 0 | 2 | 0 | 80 | 35 | 45 | 56% | 5-7 | 5.42 | 1.57 |
| 2006-06-15 | Jarrod Washburn | L | 32 | L 6-9 | @ OAK | 14 | 197 | L | 5.0 | 7 | 6 | 6 | 1 | 4 | 2 | 91 | 39 | 52 | 57% | 4-8 | 4.66 | 1.24 |
| 2006-06-16 | Felix Hernandez | R | 20 | L 5-4 | vs SFN | 14 | 26 | W | 6.0 | 6 | 4 | 4 | 3 | 3 | 5 | 103 | 41 | 62 | 60% | 7-6 | 5.04 | 1.39 |
| 2006-06-17 | Gil Meche | R | 28 | L 8-1 | vs SFN | 14 | 125 | W | 9.0 | 5 | 1 | 1 | 1 | 1 | 7 | 112 | 34 | 78 | 70% | 7-4 | 4.08 | 1.40 |
| 2006-06-18 | Jamie Moyer | L | 44 | L 5-1 | vs SFN | 15 | 500 | W | 8.0 | 6 | 1 | 1 | 1 | 0 | 4 | 97 | 31 | 66 | 68% | 4-6 | 3.58 | 1.33 |
| 2006-06-20 | Joel Pineiro | R | 28 | W 9-4 | @ LAN | 15 | 138 | W | 6.1 | 10 | 4 | 3 | 0 | 1 | 4 | 105 | 32 | 73 | 70% | 6-7 | 5.36 | 1.58 |
| 2006-06-21 | Jarrod Washburn | L | 32 | W 8-5 | @ LAN | 15 | 198 | - | 6.0 | 8 | 5 | 5 | 1 | 2 | 6 | 100 | 38 | 62 | 62% | 4-8 | 4.84 | 1.27 |
| 2006-06-22 | Felix Hernandez | R | 20 | L 2-4 | @ LAN | 15 | 27 | L | 5.2 | 11 | 4 | 4 | 0 | 0 | 6 | 106 | 38 | 68 | 64% | 7-7 | 5.10 | 1.42 |
| 2006-06-23 | Gil Meche | R | 28 | L 1-2 | @ SDN | 15 | 126 | - | 5.2 | 4 | 1 | 1 | 1 | 2 | 6 | 107 | 48 | 59 | 55% | 7-4 | 3.96 | 1.38 |
| 2006-06-24 | Jamie Moyer | L | 44 | W 9-5 | @ SDN | 16 | 501 | W | 7.0 | 4 | 2 | 2 | 2 | 1 | 4 | 102 | 40 | 62 | 61% | 5-6 | 3.51 | 1.29 |
| 2006-06-25 | Joel Pineiro | R | 28 | W 9-4 | @ SDN | 16 | 139 | - | 6.0 | 6 | 4 | 4 | 3 | 1 | 5 | 99 | 34 | 65 | 66% | 6-7 | 5.40 | 1.56 |
| 2006-06-27 | Jarrod Washburn | L | 32 | W 11-7 | @ ARI | 16 | 199 | - | 6.0 | 5 | 4 | 4 | 2 | 1 | 5 | 89 | 31 | 58 | 65% | 4-8 | 4.91 | 1.25 |
| 2006-06-28 | Felix Hernandez | R | 20 | W 10-3 | @ ARI | 16 | 28 | W | 7.0 | 7 | 2 | 2 | 0 | 1 | 4 | 97 | 34 | 63 | 65% | 8-7 | 4.92 | 1.40 |
| 2006-06-29 | Gil Meche | R | 28 | W 3-2 | @ ARI | 16 | 127 | - | 7.0 | 6 | 2 | 1 | 0 | 1 | 4 | 116 | 43 | 73 | 63% | 7-4 | 3.77 | 1.36 |
| 2006-06-30 | Jamie Moyer | L | 44 | W 0-2 | vs COL | 17 | 502 | L | 9.0 | 5 | 2 | 2 | 1 | 4 | 4 | 114 | 39 | 75 | 66% | 5-7 | 3.39 | 1.26 |
| 2006-07-01 | Joel Pineiro | R | 28 | L 8-7 | vs COL | 17 | 140 | - | 2.2 | 9 | 7 | 7 | 1 | 2 | 1 | 70 | 24 | 46 | 66% | 6-7 | 5.88 | 1.62 |
| 2006-07-02 | Jarrod Washburn | L | 32 | W 3-4 | vs COL | 17 | 200 | - | 7.0 | 6 | 2 | 2 | 0 | 4 | 3 | 108 | 40 | 68 | 63% | 4-8 | 4.75 | 1.26 |
| 2006-07-03 | Felix Hernandez | R | 20 | W 1-7 | vs ANA | 17 | 29 | L | 6.2 | 6 | 5 | 4 | 1 | 2 | 6 | 99 | 38 | 61 | 62% | 8-8 | 4.93 | 1.38 |
| 2006-07-04 | Gil Meche | R | 28 | W 6-14 | vs ANA | 17 | 128 | - | 5.0 | 5 | 5 | 4 | 1 | 2 | 3 | 86 | 33 | 53 | 62% | 7-4 | 3.93 | 1.36 |
| 2006-07-05 | Jamie Moyer | L | 44 | W 0-4 | vs ANA | 18 | 503 | L | 7.0 | 6 | 4 | 4 | 2 | 2 | 4 | 107 | 44 | 63 | 59% | 5-8 | 3.50 | 1.26 |
| 2006-07-07 | Joel Pineiro | R | 28 | W 1-6 | vs DET | 18 | 141 | L | 7.2 | 10 | 6 | 6 | 1 | 2 | 2 | 103 | 35 | 68 | 66% | 6-8 | 5.94 | 1.61 |
| 2006-07-08 | Jarrod Washburn | L | 32 | W 1-2 | vs DET | 18 | 201 | L | 6.0 | 7 | 2 | 1 | 0 | 2 | 3 | 101 | 36 | 65 | 64% | 4-9 | 4.58 | 1.28 |
| 2006-07-09 | Gil Meche | R | 28 | L 3-2 | vs DET | 18 | 129 | W | 7.0 | 4 | 2 | 2 | 1 | 2 | 8 | 126 | 46 | 80 | 63% | 8-4 | 3.85 | 1.33 |
| 2006-07-14 | Gil Meche | R | 28 | W 5-3 | @ TOR | 19 | 130 | W | 6.0 | 6 | 3 | 3 | 2 | 1 | 5 | 101 | 37 | 64 | 63% | 9-4 | 3.88 | 1.32 |
| 2006-07-15 | Jamie Moyer | L | 44 | L 6-7 | @ TOR | 19 | 504 | - | 6.1 | 12 | 6 | 6 | 3 | 1 | 4 | 109 | 36 | 73 | 67% | 5-8 | 3.76 | 1.30 |
| 2006-07-16 | Felix Hernandez | R | 20 | L 3-4 | @ TOR | 18 | 30 | - | 6.2 | 7 | 3 | 3 | 0 | 3 | 4 | 112 | 48 | 64 | 57% | 8-8 | 4.91 | 1.40 |
| 2006-07-17 | Jarrod Washburn | L | 32 | L 2-4 | @ NYA | 19 | 202 | L | 6.1 | 9 | 4 | 1 | 1 | 1 | 1 | 102 | 37 | 65 | 64% | 4-10 | 4.42 | 1.30 |
| 2006-07-18 | Joel Pineiro | R | 28 | L 4-5 | @ NYA | 19 | 142 | - | 6.0 | 7 | 2 | 2 | 1 | 1 | 5 | 93 | 32 | 61 | 66% | 6-8 | 5.79 | 1.60 |
| 2006-07-19 | Gil Meche | R | 28 | W 3-2 | @ NYA | 20 | 131 | - | 6.0 | 5 | 2 | 2 | 0 | 1 | 6 | 116 | 39 | 77 | 66% | 9-4 | 3.84 | 1.30 |
| 2006-07-21 | Jamie Moyer | L | 44 | W 4-9 | vs BOS | 20 | 505 | L | 4.1 | 6 | 8 | 7 | 5 | 2 | 0 | 78 | 32 | 46 | 59% | 5-9 | 4.09 | 1.31 |
| 2006-07-22 | Felix Hernandez | R | 20 | L 5-2 | vs BOS | 19 | 31 | W | 7.0 | 4 | 2 | 2 | 1 | 2 | 6 | 99 | 35 | 64 | 65% | 9-8 | 4.77 | 1.37 |
| 2006-07-23 | Jarrod Washburn | L | 32 | L 9-8 | vs BOS | 20 | 203 | - | 5.1 | 8 | 5 | 5 | 0 | 3 | 6 | 105 | 36 | 69 | 66% | 4-10 | 4.57 | 1.32 |
| 2006-07-24 | Joel Pineiro | R | 28 | L 7-3 | vs TOR | 20 | 143 | W | 6.0 | 10 | 3 | 3 | 2 | 1 | 5 | 109 | 36 | 73 | 67% | 7-8 | 5.72 | 1.61 |
| 2006-07-25 | Gil Meche | R | 28 | W 3-12 | vs TOR | 21 | 132 | L | 4.1 | 10 | 7 | 7 | 0 | 4 | 5 | 98 | 43 | 55 | 56% | 9-5 | 4.18 | 1.36 |
| 2006-07-26 | Jamie Moyer | L | 44 | L 7-4 | vs TOR | 21 | 506 | W | 5.0 | 8 | 4 | 4 | 0 | 1 | 3 | 103 | 32 | 71 | 69% | 6-9 | 4.20 | 1.33 |
| 2006-07-28 | Felix Hernandez | R | 20 | L 0-1 | @ CLE | 20 | 32 | L | 6.0 | 4 | 1 | 1 | 1 | 6 | 5 | 115 | 61 | 54 | 47% | 9-9 | 4.61 | 1.38 |
| 2006-07-29 | Jarrod Washburn | L | 32 | W 3-1 | @ CLE | 21 | 204 | W | 6.1 | 5 | 1 | 1 | 0 | 1 | 5 | 96 | 37 | 59 | 61% | 5-10 | 4.43 | 1.31 |
| 2006-07-30 | Joel Pineiro | R | 28 | W 7-3 | @ CLE | 21 | 144 | - | 7.0 | 4 | 3 | 3 | 0 | 3 | 4 | 109 | 42 | 67 | 61% | 7-8 | 5.62 | 1.58 |
| 2006-07-31 | Gil Meche | R | 28 | W 10-5 | @ BAL | 22 | 133 | - | 5.0 | 6 | 3 | 3 | 2 | 3 | 6 | 95 | 37 | 58 | 61% | 9-5 | 4.23 | 1.38 |
| 2006-08-01 | Jamie Moyer | L | 44 | L 0-2 | @ BAL | 22 | 507 | L | 6.1 | 6 | 2 | 2 | 0 | 3 | 3 | 99 | 40 | 59 | 60% | 6-10 | 4.15 | 1.34 |
| 2006-08-02 | Felix Hernandez | R | 20 | W 2-1 | @ BAL | 21 | 33 | W | 5.0 | 4 | 1 | 1 | 0 | 4 | 4 | 87 | 35 | 52 | 60% | 10-9 | 4.50 | 1.39 |
| 2006-08-04 | Jarrod Washburn | L | 32 | W 2-5 | vs OAK | 22 | 205 | L | 7.0 | 8 | 4 | 4 | 0 | 3 | 1 | 110 | 43 | 67 | 61% | 5-11 | 4.47 | 1.32 |
| 2006-08-05 | Joel Pineiro | R | 28 | W 2-5 | vs OAK | 22 | 145 | L | 2.2 | 8 | 4 | 4 | 0 | 3 | 2 | 75 | 31 | 44 | 59% | 7-9 | 5.77 | 1.63 |
| 2006-08-06 | Gil Meche | R | 28 | W 6-7 | vs OAK | 23 | 134 | L | 5.0 | 8 | 6 | 4 | 1 | 3 | 2 | 102 | 40 | 62 | 61% | 9-6 | 4.34 | 1.41 |
| 2006-08-07 | Jamie Moyer | L | 44 | L 5-4 | vs TBA | 23 | 508 | - | 4.1 | 8 | 4 | 4 | 0 | 3 | 4 | 97 | 44 | 53 | 55% | 6-10 | 4.29 | 1.37 |
| 2006-08-08 | Felix Hernandez | R | 20 | L 5-1 | vs TBA | 22 | 34 | - | 8.0 | 5 | 1 | 1 | 0 | 1 | 5 | 111 | 43 | 68 | 61% | 10-9 | 4.30 | 1.35 |
| 2006-08-09 | Jarrod Washburn | L | 32 | L 2-0 | vs TBA | 23 | 206 | W | 6.2 | 3 | 0 | 0 | 0 | 1 | 4 | 105 | 37 | 68 | 65% | 6-11 | 4.25 | 1.28 |
| 2006-08-10 | Joel Pineiro | R | 28 | L 2-8 | @ TEX | 23 | 146 | L | 6.1 | 8 | 6 | 6 | 0 | 3 | 1 | 102 | 45 | 57 | 56% | 7-10 | 5.91 | 1.63 |
| 2006-08-11 | Gil Meche | R | 28 | L 7-14 | @ TEX | 24 | 135 | L | 1.0 | 2 | 9 | 4 | 0 | 6 | 0 | 54 | 30 | 24 | 44% | 9-7 | 4.57 | 1.46 |
| 2006-08-12 | Jamie Moyer | L | 44 | L 4-5 | @ TEX | 24 | 509 | L | 6.0 | 10 | 5 | 5 | 2 | 1 | 1 | 112 | 43 | 69 | 62% | 6-11 | 4.41 | 1.39 |
| 2006-08-13 | Felix Hernandez | R | 20 | L 6-10 | @ TEX | 23 | 35 | L | 5.2 | 6 | 7 | 6 | 0 | 4 | 8 | 128 | 54 | 74 | 58% | 10-10 | 4.50 | 1.37 |
| 2006-08-14 | Jarrod Washburn | L | 32 | L 4-5 | @ OAK | 24 | 207 | - | 5.0 | 8 | 3 | 3 | 2 | 3 | 0 | 102 | 46 | 56 | 55% | 6-11 | 4.29 | 1.32 |
| 2006-08-15 | Joel Pineiro | R | 28 | L 2-11 | @ OAK | 24 | 147 | L | 3.2 | 12 | 9 | 9 | 0 | 5 | 1 | 96 | 38 | 58 | 60% | 7-11 | 6.33 | 1.71 |
| 2006-08-16 | Gil Meche | R | 28 | L 0-4 | @ OAK | 25 | 136 | L | 5.1 | 6 | 4 | 4 | 1 | 4 | 3 | 116 | 53 | 63 | 54% | 9-8 | 4.66 | 1.48 |
| 2006-08-17 | Jamie Moyer | L | 44 | L 2-5 | @ ANA | 25 | 510 | L | 6.2 | 7 | 3 | 3 | 0 | 3 | 3 | 109 | 41 | 68 | 62% | 6-12 | 4.39 | 1.39 |
| 2006-08-18 | Felix Hernandez | R | 20 | L 0-3 | @ ANA | 24 | 36 | L | 6.0 | 7 | 3 | 3 | 1 | 1 | 6 | 107 | 38 | 69 | 64% | 10-11 | 4.50 | 1.36 |
| 2006-08-19 | Jarrod Washburn | L | 32 | L 7-9 | @ ANA | 25 | 208 | L | 5.2 | 7 | 6 | 5 | 0 | 1 | 2 | 72 | 21 | 51 | 71% | 6-12 | 4.44 | 1.32 |
| 2006-08-20 | Jake Woods | L | 25 | L 2-3 | @ ANA | 1 | 1 | - | 5.2 | 5 | 1 | 1 | 0 | 1 | 2 | 77 | 23 | 54 | 70% | 3-1 | 3.86 | 1.57 |
| 2006-08-22 | Cha-Seung Baek | R | 26 | L 6-5 | vs NYA | 1 | 6 | - | 5.0 | 3 | 3 | 3 | 1 | 3 | 6 | 102 | 39 | 63 | 62% | 0-0 | 5.40 | 1.20 |
| 2006-08-23 | Felix Hernandez | R | 20 | W 2-9 | vs NYA | 25 | 37 | L | 3.2 | 9 | 7 | 7 | 0 | 4 | 4 | 82 | 34 | 48 | 59% | 10-12 | 4.80 | 1.41 |
| 2006-08-24 | Jarrod Washburn | L | 32 | L 4-2 | vs NYA | 26 | 209 | W | 6.1 | 6 | 2 | 2 | 1 | 2 | 9 | 108 | 40 | 68 | 63% | 7-12 | 4.36 | 1.32 |
| 2006-08-25 | Jake Woods | L | 25 | L 6-0 | vs BOS | 2 | 2 | W | 5.0 | 3 | 0 | 0 | 0 | 3 | 4 | 86 | 38 | 48 | 56% | 4-1 | 3.57 | 1.54 |
| 2006-08-26 | Gil Meche | R | 28 | L 4-3 | vs BOS | 26 | 137 | - | 7.0 | 5 | 2 | 2 | 1 | 1 | 7 | 107 | 32 | 75 | 70% | 9-8 | 4.56 | 1.45 |
| 2006-08-27 | Cha-Seung Baek | R | 26 | L 6-3 | vs BOS | 2 | 7 | W | 5.2 | 2 | 3 | 2 | 2 | 5 | 4 | 106 | 38 | 68 | 64% | 1-0 | 4.09 | 1.18 |
| 2006-08-28 | Felix Hernandez | R | 20 | L 2-0 | vs ANA | 26 | 38 | W | 9.0 | 5 | 0 | 0 | 0 | 0 | 4 | 95 | 25 | 70 | 74% | 11-12 | 4.53 | 1.37 |
| 2006-08-29 | Jarrod Washburn | L | 32 | L 6-4 | vs ANA | 27 | 210 | W | 7.0 | 6 | 3 | 3 | 2 | 2 | 4 | 97 | 35 | 62 | 64% | 8-12 | 4.34 | 1.31 |
| 2006-08-30 | Jake Woods | L | 25 | W 3-5 | vs ANA | 3 | 3 | L | 5.0 | 8 | 4 | 4 | 1 | 2 | 2 | 95 | 37 | 58 | 61% | 4-2 | 3.82 | 1.58 |
| 2006-09-01 | Gil Meche | R | 28 | L 1-2 | @ TBA | 27 | 138 | - | 8.0 | 3 | 1 | 1 | 0 | 1 | 8 | 115 | 41 | 74 | 64% | 9-8 | 4.39 | 1.40 |
| 2006-09-02 | Cha-Seung Baek | R | 26 | W 4-3 | @ TBA | 3 | 8 | W | 6.2 | 6 | 1 | 1 | 1 | 1 | 4 | 106 | 37 | 69 | 65% | 2-0 | 3.18 | 1.18 |
| 2006-09-03 | Felix Hernandez | R | 20 | L 6-7 | @ TBA | 27 | 39 | L | 7.2 | 10 | 7 | 7 | 3 | 1 | 7 | 106 | 32 | 74 | 70% | 11-13 | 4.71 | 1.38 |
| 2006-09-04 | Jarrod Washburn | L | 32 | L 2-6 | @ DET | 28 | 211 | L | 6.2 | 6 | 6 | 6 | 1 | 2 | 3 | 95 | 39 | 56 | 59% | 8-13 | 4.50 | 1.31 |
| 2006-09-05 | Jake Woods | L | 25 | W 4-3 | @ DET | 4 | 4 | - | 4.0 | 5 | 3 | 3 | 0 | 2 | 2 | 74 | 26 | 48 | 65% | 4-2 | 3.97 | 1.58 |
| 2006-09-06 | Gil Meche | R | 28 | W 5-4 | @ DET | 28 | 139 | - | 7.0 | 5 | 2 | 2 | 2 | 3 | 3 | 97 | 34 | 63 | 65% | 9-8 | 4.31 | 1.39 |
| 2006-09-08 | Cha-Seung Baek | R | 26 | L 7-2 | vs TEX | 4 | 9 | W | 7.0 | 4 | 0 | 0 | 0 | 0 | 3 | 93 | 33 | 60 | 65% | 3-0 | 2.25 | 1.00 |
| 2006-09-09 | Jarrod Washburn | L | 32 | L 3-2 | vs TEX | 29 | 212 | - | 6.0 | 6 | 1 | 1 | 0 | 2 | 5 | 104 | 39 | 65 | 63% | 8-13 | 4.40 | 1.31 |
| 2006-09-10 | Felix Hernandez | R | 20 | W 2-4 | vs TEX | 28 | 40 | - | 5.2 | 7 | 1 | 1 | 0 | 1 | 5 | 103 | 34 | 69 | 67% | 11-13 | 4.60 | 1.37 |
| 2006-09-11 | Jake Woods | L | 25 | W 2-6 | vs TOR | 5 | 5 | L | 5.1 | 8 | 5 | 5 | 0 | 3 | 4 | 102 | 41 | 61 | 60% | 4-3 | 4.28 | 1.62 |
| 2006-09-12 | Gil Meche | R | 28 | L 4-2 | vs TOR | 29 | 140 | W | 5.1 | 5 | 2 | 2 | 1 | 2 | 7 | 91 | 28 | 63 | 69% | 10-8 | 4.29 | 1.39 |
| 2006-09-13 | Cha-Seung Baek | R | 26 | W 0-10 | vs TOR | 5 | 10 | L | 3.1 | 7 | 6 | 6 | 1 | 3 | 1 | 66 | 24 | 42 | 64% | 3-1 | 3.86 | 1.21 |
| 2006-09-14 | Jarrod Washburn | L | 32 | L 8-10 | @ KCA | 30 | 213 | L | 4.1 | 10 | 6 | 6 | 1 | 1 | 1 | 79 | 32 | 47 | 59% | 8-14 | 4.57 | 1.34 |
| 2006-09-15 | Francisco Cruceta | R | 25 | W 11-8 | @ KCA | 1 | 3 | - | 1.0 | 4 | 5 | 5 | 1 | 2 | 0 | 39 | 16 | 23 | 59% | 0-0 | 27.00 | 4.50 |
| 2006-09-16 | Joel Pineiro | R | 28 | L 4-7 | @ KCA | 25 | 148 | L | 4.0 | 7 | 7 | 7 | 1 | 1 | 2 | 64 | 20 | 44 | 69% | 8-12 | 6.27 | 1.66 |
| 2006-09-17 | Gil Meche | R | 28 | W 10-5 | @ KCA | 30 | 141 | W | 6.0 | 9 | 5 | 4 | 0 | 2 | 3 | 113 | 44 | 69 | 61% | 11-8 | 4.35 | 1.40 |
| 2006-09-18 | Felix Hernandez | R | 20 | L 1-8 | @ TEX | 29 | 41 | L | 5.0 | 7 | 4 | 4 | 0 | 2 | 9 | 97 | 38 | 59 | 61% | 11-14 | 4.68 | 1.39 |
| 2006-09-19 | Jarrod Washburn | L | 32 | W 9-7 | @ TEX | 31 | 214 | - | 2.1 | 4 | 3 | 3 | 2 | 2 | 1 | 64 | 28 | 36 | 56% | 8-14 | 4.67 | 1.35 |
| 2006-09-20 | Cha-Seung Baek | R | 26 | W 6-3 | @ TEX | 6 | 11 | W | 6.2 | 4 | 2 | 2 | 1 | 1 | 5 | 103 | 31 | 72 | 70% | 4-1 | 3.71 | 1.15 |
| 2006-09-21 | Jake Woods | L | 25 | W 9-0 | @ CHA | 6 | 6 | W | 7.0 | 5 | 0 | 0 | 0 | 0 | 4 | 106 | 41 | 65 | 61% | 6-3 | 3.88 | 1.54 |
| 2006-09-22 | Gil Meche | R | 28 | W 11-6 | @ CHA | 31 | 142 | - | 4.1 | 6 | 6 | 5 | 1 | 3 | 4 | 92 | 38 | 54 | 59% | 11-8 | 4.48 | 1.41 |
| 2006-09-23 | Felix Hernandez | R | 20 | L 7-11 | @ CHA | 30 | 42 | - | 5.0 | 3 | 2 | 2 | 1 | 0 | 6 | 66 | 18 | 48 | 73% | 11-14 | 4.65 | 1.36 |
| 2006-09-24 | Ryan Feierabend | L | 21 | L 7-12 | @ CHA | 1 | 1 | L | 6.0 | 8 | 5 | 5 | 3 | 3 | 4 | 105 | 43 | 62 | 59% | 0-1 | 3.75 | 1.08 |
| 2006-09-25 | Cesar Jimenez | L | 22 | L 10-9 | vs OAK | 1 | 1 | - | 4.0 | 8 | 5 | 5 | 1 | 1 | 2 | 74 | 29 | 45 | 61% | 0-0 | 15.43 | 2.43 |
| 2006-09-26 | Jake Woods | L | 25 | W 3-12 | vs OAK | 7 | 7 | L | 4.0 | 11 | 6 | 6 | 2 | 3 | 2 | 89 | 28 | 61 | 69% | 6-4 | 4.27 | 1.62 |
| 2006-09-27 | Gil Meche | R | 28 | W 6-7 | vs OAK | 32 | 143 | - | 6.0 | 6 | 3 | 3 | 0 | 5 | 7 | 124 | 51 | 73 | 59% | 11-8 | 4.48 | 1.43 |
| 2006-09-29 | Ryan Feierabend | L | 21 | W 5-6 | vs TEX | 2 | 2 | - | 5.0 | 6 | 2 | 2 | 0 | 3 | 3 | 93 | 37 | 56 | 60% | 0-1 | 3.71 | 1.29 |
| 2006-09-30 | Felix Hernandez | R | 20 | L 3-1 | vs TEX | 31 | 43 | W | 7.0 | 4 | 1 | 1 | 1 | 0 | 5 | 84 | 26 | 58 | 69% | 12-14 | 4.52 | 1.34 |
| 2006-10-01 | Jake Woods | L | 25 | L 3-2 | vs TEX | 8 | 8 | W | 6.0 | 8 | 2 | 2 | 1 | 0 | 6 | 91 | 28 | 63 | 69% | 7-4 | 4.20 | 1.60 |