| West | W | L | Pct | GB |
| Oakland | 93 | 69 | .574 | -- |
| LA Angels | 89 | 73 | .549 | 4.0 |
| Texas | 80 | 82 | .494 | 13.0 |
| Seattle | 78 | 84 | .481 | 15.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2006-04-03 | Bartolo Colon | R | 31 | W 5-4 | @ SEA | 1 | 279 | - | 5.0 | 8 | 3 | 3 | 1 | 1 | 4 | 101 | 30 | 71 | 70% | 0-0 | 5.40 | 1.80 |
| 2006-04-04 | John Lackey | R | 27 | L 8-10 | @ SEA | 1 | 117 | L | 4.0 | 9 | 5 | 5 | 1 | 1 | 4 | 90 | 29 | 61 | 68% | 0-1 | 11.25 | 2.50 |
| 2006-04-05 | Jeff Weaver | R | 30 | L 4-6 | @ SEA | 1 | 210 | L | 6.1 | 9 | 5 | 5 | 0 | 2 | 2 | 108 | 34 | 74 | 69% | 0-1 | 7.50 | 1.83 |
| 2006-04-07 | Kelvim Escobar | R | 30 | L 4-1 | vs NYA | 1 | 142 | W | 6.0 | 6 | 1 | 1 | 0 | 0 | 2 | 96 | 34 | 62 | 65% | 1-0 | 1.50 | 1.00 |
| 2006-04-08 | Ervin Santana | R | 23 | L 3-2 | vs NYA | 1 | 24 | W | 5.2 | 2 | 1 | 1 | 1 | 3 | 2 | 100 | 41 | 59 | 59% | 1-0 | 1.50 | 0.83 |
| 2006-04-09 | Bartolo Colon | R | 31 | W 1-10 | vs NYA | 2 | 280 | L | 2.0 | 7 | 8 | 7 | 2 | 2 | 1 | 51 | 19 | 32 | 63% | 0-1 | 12.86 | 2.57 |
| 2006-04-10 | John Lackey | R | 27 | L 5-2 | vs TEX | 2 | 118 | W | 7.0 | 4 | 2 | 2 | 1 | 1 | 8 | 97 | 28 | 69 | 71% | 1-1 | 5.73 | 1.36 |
| 2006-04-11 | Jeff Weaver | R | 30 | L 5-4 | vs TEX | 2 | 211 | - | 6.0 | 9 | 4 | 4 | 2 | 1 | 5 | 102 | 32 | 70 | 69% | 0-1 | 6.75 | 1.75 |
| 2006-04-12 | Kelvim Escobar | R | 30 | W 3-11 | vs TEX | 2 | 143 | L | 4.1 | 8 | 8 | 4 | 1 | 2 | 4 | 96 | 32 | 64 | 67% | 1-1 | 4.50 | 1.60 |
| 2006-04-14 | Ervin Santana | R | 23 | L 5-6 | @ BAL | 2 | 25 | - | 7.0 | 6 | 4 | 4 | 3 | 0 | 2 | 83 | 27 | 56 | 67% | 1-0 | 3.46 | 0.85 |
| 2006-04-15 | Bartolo Colon | R | 31 | L 2-3 | @ BAL | 3 | 281 | L | 7.0 | 8 | 3 | 1 | 0 | 1 | 4 | 95 | 30 | 65 | 68% | 0-2 | 7.07 | 1.93 |
| 2006-04-16 | John Lackey | R | 27 | W 9-3 | @ BAL | 3 | 119 | W | 8.0 | 6 | 2 | 2 | 1 | 0 | 5 | 90 | 32 | 58 | 64% | 2-1 | 4.26 | 1.11 |
| 2006-04-17 | Jeff Weaver | R | 30 | L 2-4 | @ BAL | 3 | 212 | L | 7.0 | 5 | 4 | 2 | 1 | 1 | 4 | 100 | 35 | 65 | 65% | 0-2 | 5.21 | 1.42 |
| 2006-04-18 | Kelvim Escobar | R | 30 | W 8-2 | @ MIN | 3 | 144 | W | 6.2 | 7 | 2 | 2 | 0 | 2 | 10 | 106 | 38 | 68 | 64% | 2-1 | 3.71 | 1.47 |
| 2006-04-19 | Ervin Santana | R | 23 | L 10-12 | @ MIN | 3 | 26 | - | 5.2 | 7 | 7 | 3 | 0 | 3 | 5 | 102 | 36 | 66 | 65% | 1-0 | 4.00 | 1.17 |
| 2006-04-20 | Hector Carrasco | R | 37 | W 6-4 | @ MIN | 1 | 7 | - | 3.0 | 4 | 3 | 3 | 0 | 3 | 4 | 79 | 37 | 42 | 53% | 0-0 | 4.50 | 1.42 |
| 2006-04-21 | John Lackey | R | 27 | L 3-5 | @ OAK | 4 | 120 | - | 5.0 | 2 | 2 | 2 | 0 | 7 | 3 | 120 | 53 | 67 | 56% | 2-1 | 4.13 | 1.25 |
| 2006-04-22 | Jeff Weaver | R | 30 | W 5-4 | @ OAK | 4 | 213 | W | 6.0 | 6 | 4 | 4 | 1 | 1 | 5 | 98 | 32 | 66 | 67% | 1-2 | 5.40 | 1.36 |
| 2006-04-23 | Kelvim Escobar | R | 30 | W 4-3 | @ OAK | 4 | 145 | W | 7.0 | 5 | 3 | 3 | 2 | 2 | 4 | 98 | 36 | 62 | 63% | 3-1 | 3.75 | 1.33 |
| 2006-04-24 | Ervin Santana | R | 23 | L 3-0 | vs DET | 4 | 27 | W | 6.0 | 5 | 0 | 0 | 0 | 2 | 10 | 111 | 46 | 65 | 59% | 2-0 | 3.00 | 1.17 |
| 2006-04-25 | Hector Carrasco | R | 38 | W 2-5 | vs DET | 2 | 8 | L | 5.0 | 7 | 5 | 5 | 1 | 1 | 3 | 82 | 25 | 57 | 70% | 0-1 | 5.82 | 1.47 |
| 2006-04-26 | John Lackey | R | 28 | L 4-0 | vs DET | 5 | 121 | W | 8.0 | 1 | 0 | 0 | 0 | 5 | 8 | 116 | 40 | 76 | 66% | 3-1 | 3.09 | 1.13 |
| 2006-04-28 | Jeff Weaver | R | 30 | W 5-8 | vs CHA | 5 | 214 | L | 2.1 | 8 | 8 | 8 | 1 | 2 | 4 | 66 | 25 | 41 | 62% | 1-3 | 7.39 | 1.57 |
| 2006-04-29 | Kelvim Escobar | R | 30 | W 1-2 | vs CHA | 5 | 146 | L | 5.0 | 3 | 1 | 1 | 0 | 1 | 3 | 69 | 27 | 42 | 61% | 3-2 | 3.41 | 1.24 |
| 2006-04-30 | Ervin Santana | R | 23 | W 5-6 | vs CHA | 5 | 28 | - | 7.0 | 8 | 5 | 5 | 0 | 1 | 4 | 99 | 35 | 64 | 65% | 2-0 | 3.77 | 1.19 |
| 2006-05-01 | Hector Carrasco | R | 38 | W 0-1 | vs OAK | 3 | 9 | L | 6.0 | 3 | 1 | 1 | 0 | 2 | 3 | 89 | 30 | 59 | 66% | 0-2 | 4.70 | 1.30 |
| 2006-05-02 | John Lackey | R | 28 | W 3-10 | vs OAK | 6 | 122 | L | 5.1 | 6 | 4 | 4 | 1 | 2 | 6 | 97 | 33 | 64 | 66% | 3-2 | 3.65 | 1.19 |
| 2006-05-03 | Jeff Weaver | R | 30 | L 1-2 | @ DET | 6 | 215 | L | 7.1 | 5 | 2 | 2 | 1 | 2 | 4 | 111 | 39 | 72 | 65% | 1-4 | 6.43 | 1.46 |
| 2006-05-04 | Kevin Gregg | R | 28 | W 7-2 | @ DET | 1 | 6 | W | 7.0 | 3 | 1 | 1 | 0 | 0 | 3 | 89 | 33 | 56 | 63% | 2-0 | 1.00 | 0.83 |
| 2006-05-05 | Ervin Santana | R | 23 | L 3-13 | @ TOR | 6 | 29 | L | 4.0 | 9 | 6 | 6 | 0 | 4 | 4 | 91 | 37 | 54 | 59% | 2-1 | 4.89 | 1.43 |
| 2006-05-06 | Kelvim Escobar | R | 30 | W 3-0 | @ TOR | 6 | 147 | W | 6.2 | 3 | 0 | 0 | 0 | 2 | 6 | 97 | 37 | 60 | 62% | 4-2 | 2.75 | 1.14 |
| 2006-05-07 | John Lackey | R | 28 | L 1-3 | @ TOR | 7 | 123 | L | 8.0 | 6 | 3 | 2 | 1 | 0 | 3 | 111 | 33 | 78 | 70% | 3-3 | 3.40 | 1.11 |
| 2006-05-08 | Jeff Weaver | R | 30 | L 1-5 | @ TOR | 7 | 216 | L | 6.1 | 7 | 5 | 5 | 2 | 3 | 1 | 100 | 36 | 64 | 64% | 1-5 | 6.59 | 1.49 |
| 2006-05-09 | Kevin Gregg | R | 28 | L 1-9 | @ CHA | 2 | 7 | L | 2.2 | 9 | 7 | 7 | 2 | 1 | 0 | 70 | 29 | 41 | 59% | 2-1 | 4.05 | 1.25 |
| 2006-05-10 | Ervin Santana | R | 23 | W 12-5 | @ CHA | 7 | 30 | W | 6.0 | 3 | 3 | 3 | 1 | 1 | 7 | 99 | 38 | 61 | 62% | 3-1 | 4.83 | 1.32 |
| 2006-05-12 | Kelvim Escobar | R | 30 | L 12-7 | vs SEA | 7 | 148 | W | 6.0 | 11 | 6 | 5 | 1 | 0 | 3 | 94 | 30 | 64 | 68% | 5-2 | 3.43 | 1.24 |
| 2006-05-13 | John Lackey | R | 28 | W 4-5 | vs SEA | 8 | 124 | - | 7.0 | 7 | 4 | 4 | 2 | 0 | 7 | 116 | 37 | 79 | 68% | 3-3 | 3.63 | 1.10 |
| 2006-05-14 | Jeff Weaver | R | 30 | W 4-9 | vs SEA | 8 | 217 | L | 3.2 | 7 | 7 | 7 | 4 | 0 | 1 | 59 | 21 | 38 | 64% | 1-6 | 7.40 | 1.51 |
| 2006-05-16 | Ervin Santana | R | 23 | L 8-3 | vs TOR | 8 | 31 | W | 6.2 | 5 | 3 | 2 | 0 | 0 | 3 | 106 | 40 | 66 | 62% | 4-1 | 4.50 | 1.23 |
| 2006-05-17 | Kelvim Escobar | R | 30 | W 0-3 | vs TOR | 8 | 149 | L | 7.0 | 12 | 3 | 3 | 1 | 2 | 5 | 106 | 34 | 72 | 68% | 5-3 | 3.49 | 1.35 |
| 2006-05-18 | John Lackey | R | 28 | W 4-8 | vs TOR | 9 | 125 | - | 6.0 | 4 | 3 | 3 | 0 | 5 | 3 | 104 | 45 | 59 | 57% | 3-3 | 3.72 | 1.14 |
| 2006-05-19 | Jeff Weaver | R | 30 | L 3-16 | @ LAN | 9 | 218 | L | 4.1 | 11 | 4 | 3 | 0 | 2 | 2 | 80 | 32 | 48 | 60% | 1-7 | 7.35 | 1.65 |
| 2006-05-20 | Kevin Gregg | R | 28 | L 4-8 | @ LAN | 3 | 8 | - | 6.0 | 7 | 4 | 4 | 1 | 1 | 7 | 108 | 39 | 69 | 64% | 2-2 | 4.34 | 1.28 |
| 2006-05-21 | Ervin Santana | R | 23 | L 0-7 | @ LAN | 9 | 32 | L | 4.0 | 5 | 5 | 5 | 1 | 1 | 2 | 54 | 20 | 34 | 63% | 4-2 | 5.02 | 1.25 |
| 2006-05-22 | Kelvim Escobar | R | 30 | L 2-3 | @ TEX | 9 | 150 | L | 6.1 | 8 | 3 | 3 | 1 | 1 | 6 | 100 | 37 | 63 | 63% | 5-4 | 3.60 | 1.36 |
| 2006-05-23 | John Lackey | R | 28 | W 7-6 | @ TEX | 10 | 126 | - | 6.0 | 5 | 4 | 1 | 0 | 3 | 4 | 106 | 37 | 69 | 65% | 3-3 | 3.52 | 1.16 |
| 2006-05-24 | Jeff Weaver | R | 30 | W 8-5 | @ TEX | 10 | 219 | W | 6.0 | 5 | 3 | 3 | 1 | 2 | 5 | 107 | 38 | 69 | 64% | 2-7 | 7.04 | 1.60 |
| 2006-05-26 | Ervin Santana | R | 23 | L 5-2 | vs BAL | 10 | 33 | - | 7.0 | 6 | 2 | 2 | 0 | 2 | 2 | 105 | 44 | 61 | 58% | 4-2 | 4.73 | 1.24 |
| 2006-05-27 | Jered Weaver | R | 24 | L 10-1 | vs BAL | 1 | 1 | W | 7.0 | 3 | 0 | 0 | 0 | 1 | 5 | 95 | 33 | 62 | 65% | 1-0 | 0.00 | 0.57 |
| 2006-05-28 | Kelvim Escobar | R | 30 | W 6-7 | vs BAL | 10 | 151 | L | 6.1 | 8 | 5 | 5 | 0 | 0 | 4 | 95 | 33 | 62 | 65% | 5-5 | 3.98 | 1.36 |
| 2006-05-29 | John Lackey | R | 28 | L 4-3 | vs MIN | 11 | 127 | - | 8.0 | 7 | 3 | 2 | 1 | 1 | 7 | 110 | 40 | 70 | 64% | 3-3 | 3.38 | 1.14 |
| 2006-05-30 | Jeff Weaver | R | 30 | L 6-3 | vs MIN | 11 | 220 | W | 7.0 | 6 | 3 | 3 | 2 | 0 | 4 | 92 | 35 | 57 | 62% | 3-7 | 6.68 | 1.52 |
| 2006-05-31 | Ervin Santana | R | 23 | W 1-7 | vs MIN | 11 | 34 | L | 7.0 | 9 | 4 | 3 | 0 | 0 | 3 | 89 | 28 | 61 | 69% | 4-3 | 4.64 | 1.24 |
| 2006-06-02 | Jered Weaver | R | 24 | W 10-3 | @ CLE | 2 | 2 | W | 6.1 | 4 | 2 | 2 | 0 | 2 | 8 | 98 | 38 | 60 | 61% | 2-0 | 1.38 | 0.77 |
| 2006-06-03 | Kelvim Escobar | R | 30 | L 2-14 | @ CLE | 11 | 152 | L | 5.2 | 6 | 8 | 2 | 1 | 5 | 6 | 118 | 51 | 67 | 57% | 5-6 | 3.90 | 1.40 |
| 2006-06-04 | John Lackey | R | 28 | W 14-2 | @ CLE | 12 | 128 | W | 7.0 | 2 | 0 | 0 | 0 | 4 | 4 | 118 | 44 | 74 | 63% | 4-3 | 3.08 | 1.11 |
| 2006-06-05 | Jeff Weaver | R | 30 | L 0-4 | @ TBA | 12 | 221 | L | 6.2 | 7 | 4 | 3 | 0 | 3 | 3 | 102 | 36 | 66 | 65% | 3-8 | 6.39 | 1.51 |
| 2006-06-06 | Ervin Santana | R | 23 | W 12-2 | @ TBA | 12 | 35 | W | 7.0 | 2 | 1 | 1 | 0 | 1 | 7 | 103 | 39 | 64 | 62% | 5-3 | 4.32 | 1.16 |
| 2006-06-07 | Jered Weaver | R | 24 | W 6-2 | @ TBA | 3 | 3 | W | 6.0 | 4 | 2 | 2 | 2 | 0 | 4 | 91 | 35 | 56 | 62% | 3-0 | 1.89 | 0.74 |
| 2006-06-09 | Kelvim Escobar | R | 30 | W 1-4 | vs SEA | 12 | 153 | L | 8.0 | 7 | 4 | 2 | 1 | 3 | 4 | 109 | 42 | 67 | 61% | 5-7 | 3.72 | 1.39 |
| 2006-06-10 | John Lackey | R | 28 | W 6-12 | vs SEA | 13 | 129 | L | 4.2 | 9 | 8 | 8 | 1 | 3 | 1 | 93 | 36 | 57 | 61% | 4-4 | 3.75 | 1.19 |
| 2006-06-11 | Jeff Weaver | R | 30 | W 2-6 | vs SEA | 13 | 222 | L | 5.2 | 7 | 4 | 2 | 1 | 1 | 5 | 107 | 39 | 68 | 64% | 3-9 | 6.12 | 1.49 |
| 2006-06-12 | Ervin Santana | R | 23 | L 4-3 | vs KCA | 13 | 36 | W | 6.2 | 6 | 3 | 3 | 1 | 1 | 4 | 96 | 32 | 64 | 67% | 6-3 | 4.28 | 1.15 |
| 2006-06-13 | Jered Weaver | R | 24 | L 4-1 | vs KCA | 4 | 4 | W | 7.0 | 5 | 1 | 0 | 0 | 1 | 5 | 99 | 34 | 65 | 66% | 4-0 | 1.38 | 0.77 |
| 2006-06-14 | Kelvim Escobar | R | 30 | W 3-4 | vs KCA | 13 | 154 | - | 7.0 | 5 | 3 | 2 | 1 | 1 | 5 | 104 | 40 | 64 | 62% | 5-7 | 3.62 | 1.34 |
| 2006-06-15 | John Lackey | R | 28 | L 3-2 | vs KCA | 14 | 130 | - | 7.0 | 4 | 1 | 0 | 0 | 1 | 8 | 104 | 33 | 71 | 68% | 4-4 | 3.46 | 1.15 |
| 2006-06-16 | Jeff Weaver | R | 30 | W 4-5 | vs SDN | 14 | 223 | - | 6.0 | 7 | 3 | 3 | 1 | 0 | 9 | 100 | 34 | 66 | 66% | 3-9 | 6.00 | 1.47 |
| 2006-06-17 | Ervin Santana | R | 23 | L 3-2 | vs SDN | 14 | 37 | W | 6.0 | 3 | 1 | 1 | 0 | 3 | 7 | 107 | 46 | 61 | 57% | 7-3 | 4.08 | 1.14 |
| 2006-06-18 | Bartolo Colon | R | 31 | W 3-7 | vs SDN | 4 | 282 | L | 7.0 | 9 | 4 | 2 | 2 | 1 | 5 | 102 | 34 | 68 | 67% | 0-3 | 5.57 | 1.76 |
| 2006-06-19 | Kelvim Escobar | R | 30 | L 1-2 | @ SFN | 14 | 155 | L | 7.0 | 4 | 2 | 2 | 0 | 2 | 4 | 87 | 31 | 56 | 64% | 5-8 | 3.54 | 1.30 |
| 2006-06-20 | John Lackey | R | 28 | L 2-3 | @ SFN | 15 | 131 | L | 7.0 | 5 | 3 | 1 | 0 | 2 | 2 | 113 | 39 | 74 | 65% | 4-5 | 3.31 | 1.14 |
| 2006-06-21 | Jeff Weaver | R | 30 | W 6-3 | @ SFN | 15 | 224 | - | 6.0 | 6 | 2 | 2 | 0 | 1 | 7 | 100 | 33 | 67 | 67% | 3-9 | 5.79 | 1.45 |
| 2006-06-23 | Ervin Santana | R | 23 | W 8-2 | @ ARI | 15 | 38 | W | 6.0 | 7 | 2 | 2 | 1 | 6 | 2 | 108 | 45 | 63 | 58% | 8-3 | 4.01 | 1.21 |
| 2006-06-24 | Bartolo Colon | R | 31 | W 6-4 | @ ARI | 5 | 283 | - | 5.2 | 8 | 4 | 4 | 2 | 2 | 4 | 91 | 36 | 55 | 60% | 0-3 | 5.67 | 1.74 |
| 2006-06-25 | Kelvim Escobar | R | 30 | L 7-9 | @ ARI | 15 | 156 | L | 4.2 | 9 | 8 | 8 | 1 | 5 | 4 | 98 | 37 | 61 | 62% | 5-9 | 4.12 | 1.38 |
| 2006-06-26 | John Lackey | R | 28 | L 5-4 | vs COL | 16 | 132 | W | 8.0 | 4 | 3 | 3 | 1 | 2 | 4 | 107 | 40 | 67 | 63% | 5-5 | 3.31 | 1.11 |
| 2006-06-27 | Jeff Weaver | R | 30 | W 4-12 | vs COL | 16 | 225 | L | 2.0 | 9 | 6 | 6 | 1 | 0 | 1 | 55 | 17 | 38 | 69% | 3-10 | 6.27 | 1.52 |
| 2006-06-28 | Ervin Santana | R | 23 | W 2-6 | vs COL | 16 | 39 | - | 7.0 | 4 | 2 | 2 | 0 | 4 | 6 | 114 | 44 | 70 | 61% | 8-3 | 3.91 | 1.20 |
| 2006-06-30 | Bartolo Colon | R | 31 | W 1-6 | vs LAN | 6 | 284 | L | 7.2 | 12 | 6 | 5 | 1 | 0 | 3 | 99 | 24 | 75 | 76% | 0-4 | 5.82 | 1.74 |
| 2006-07-01 | Kelvim Escobar | R | 30 | L 9-2 | vs LAN | 16 | 157 | W | 7.0 | 8 | 0 | 0 | 0 | 0 | 6 | 103 | 33 | 70 | 68% | 6-9 | 3.83 | 1.37 |
| 2006-07-02 | John Lackey | R | 28 | L 4-0 | vs LAN | 17 | 133 | W | 6.2 | 4 | 0 | 0 | 0 | 1 | 10 | 105 | 38 | 67 | 64% | 6-5 | 3.11 | 1.09 |
| 2006-07-03 | Jered Weaver | R | 24 | W 7-1 | @ SEA | 5 | 5 | W | 7.0 | 5 | 1 | 1 | 0 | 1 | 9 | 107 | 38 | 69 | 64% | 5-0 | 1.36 | 0.79 |
| 2006-07-04 | Ervin Santana | R | 23 | W 14-6 | @ SEA | 17 | 40 | W | 8.0 | 6 | 6 | 6 | 2 | 1 | 6 | 104 | 36 | 68 | 65% | 9-3 | 4.12 | 1.18 |
| 2006-07-05 | Bartolo Colon | R | 31 | W 4-0 | @ SEA | 7 | 285 | W | 9.0 | 4 | 0 | 0 | 0 | 0 | 2 | 90 | 23 | 67 | 74% | 1-4 | 4.60 | 1.47 |
| 2006-07-06 | Kelvim Escobar | R | 30 | L 5-7 | @ OAK | 17 | 158 | - | 6.0 | 6 | 5 | 3 | 2 | 4 | 3 | 111 | 47 | 64 | 58% | 6-9 | 3.87 | 1.38 |
| 2006-07-07 | John Lackey | R | 28 | W 3-0 | @ OAK | 18 | 134 | W | 9.0 | 1 | 0 | 0 | 0 | 0 | 10 | 109 | 32 | 77 | 71% | 7-5 | 2.88 | 1.02 |
| 2006-07-08 | Jered Weaver | R | 24 | W 6-4 | @ OAK | 6 | 6 | W | 7.0 | 2 | 0 | 0 | 0 | 2 | 5 | 97 | 41 | 56 | 58% | 6-0 | 1.13 | 0.75 |
| 2006-07-09 | Ervin Santana | R | 23 | W 4-2 | @ OAK | 18 | 41 | W | 7.0 | 5 | 2 | 1 | 0 | 3 | 5 | 109 | 43 | 66 | 61% | 10-3 | 3.95 | 1.18 |
| 2006-07-14 | John Lackey | R | 28 | L 4-0 | vs TBA | 19 | 135 | W | 9.0 | 5 | 0 | 0 | 0 | 2 | 10 | 106 | 33 | 73 | 69% | 8-5 | 2.68 | 1.00 |
| 2006-07-15 | Ervin Santana | R | 24 | L 9-2 | vs TBA | 19 | 42 | W | 7.0 | 4 | 2 | 2 | 0 | 2 | 6 | 90 | 32 | 58 | 64% | 11-3 | 3.87 | 1.16 |
| 2006-07-16 | Bartolo Colon | R | 31 | L 7-5 | vs TBA | 8 | 286 | - | 6.0 | 7 | 3 | 3 | 0 | 2 | 6 | 102 | 35 | 67 | 66% | 1-4 | 4.59 | 1.47 |
| 2006-07-17 | Dustin Moseley | R | 25 | L 10-5 | vs CLE | 1 | 1 | W | 5.0 | 10 | 4 | 4 | 2 | 0 | 2 | 91 | 36 | 55 | 60% | 1-0 | 7.20 | 2.00 |
| 2006-07-18 | Joe Saunders | L | 25 | L 7-5 | vs CLE | 1 | 3 | W | 7.0 | 4 | 2 | 1 | 0 | 4 | 5 | 101 | 44 | 57 | 56% | 1-0 | 1.29 | 1.14 |
| 2006-07-19 | John Lackey | R | 28 | W 4-6 | vs CLE | 20 | 136 | L | 4.2 | 10 | 5 | 5 | 1 | 5 | 7 | 107 | 40 | 67 | 63% | 8-6 | 2.93 | 1.08 |
| 2006-07-20 | Ervin Santana | R | 24 | L 4-9 | @ KCA | 20 | 43 | - | 4.1 | 5 | 4 | 4 | 0 | 8 | 4 | 119 | 67 | 52 | 44% | 11-3 | 4.03 | 1.22 |
| 2006-07-21 | Bartolo Colon | R | 31 | L 3-8 | @ KCA | 9 | 287 | L | 6.0 | 4 | 4 | 3 | 1 | 2 | 1 | 98 | 28 | 70 | 71% | 1-5 | 4.58 | 1.42 |
| 2006-07-22 | Kelvim Escobar | R | 30 | W 4-3 | @ KCA | 18 | 159 | - | 7.0 | 9 | 3 | 3 | 0 | 2 | 3 | 100 | 34 | 66 | 66% | 6-9 | 3.87 | 1.39 |
| 2006-07-23 | Jered Weaver | R | 24 | W 3-1 | @ KCA | 7 | 7 | W | 6.2 | 3 | 1 | 1 | 0 | 4 | 4 | 104 | 45 | 59 | 57% | 7-0 | 1.15 | 0.79 |
| 2006-07-24 | John Lackey | R | 28 | W 8-4 | @ TBA | 21 | 137 | W | 8.0 | 5 | 4 | 2 | 0 | 1 | 7 | 107 | 30 | 77 | 72% | 9-6 | 2.90 | 1.06 |
| 2006-07-25 | Ervin Santana | R | 24 | L 3-6 | @ TBA | 21 | 44 | L | 6.1 | 9 | 6 | 6 | 1 | 0 | 6 | 98 | 27 | 71 | 72% | 11-4 | 4.26 | 1.24 |
| 2006-07-26 | Bartolo Colon | R | 31 | W 15-6 | @ TBA | 10 | 288 | - | 1.0 | 4 | 4 | 4 | 2 | 0 | 1 | 25 | 10 | 15 | 60% | 1-5 | 5.14 | 1.46 |
| 2006-07-28 | Kelvim Escobar | R | 30 | W 8-3 | @ BOS | 19 | 160 | W | 6.0 | 6 | 2 | 2 | 0 | 2 | 8 | 100 | 39 | 61 | 61% | 7-9 | 3.83 | 1.39 |
| 2006-07-29 | Jered Weaver | R | 24 | L 6-7 | @ BOS | 8 | 8 | - | 6.2 | 7 | 3 | 3 | 0 | 2 | 4 | 101 | 39 | 62 | 61% | 7-0 | 1.50 | 0.85 |
| 2006-07-30 | John Lackey | R | 28 | W 10-4 | @ BOS | 22 | 138 | W | 6.0 | 9 | 4 | 3 | 0 | 2 | 6 | 112 | 43 | 69 | 62% | 10-6 | 2.96 | 1.09 |
| 2006-07-31 | Ervin Santana | R | 24 | W 1-3 | vs OAK | 22 | 45 | L | 8.0 | 8 | 3 | 3 | 2 | 1 | 2 | 113 | 48 | 65 | 58% | 11-5 | 4.21 | 1.23 |
| 2006-08-01 | Joe Saunders | L | 25 | L 3-2 | vs OAK | 2 | 4 | W | 7.0 | 5 | 2 | 2 | 1 | 2 | 3 | 103 | 45 | 58 | 56% | 2-0 | 1.93 | 1.07 |
| 2006-08-02 | Kelvim Escobar | R | 30 | W 2-3 | vs OAK | 20 | 161 | - | 7.0 | 3 | 2 | 2 | 0 | 1 | 4 | 94 | 29 | 65 | 69% | 7-9 | 3.76 | 1.35 |
| 2006-08-03 | Jered Weaver | R | 24 | W 6-7 | vs TEX | 9 | 9 | - | 6.0 | 8 | 3 | 3 | 0 | 1 | 3 | 104 | 37 | 67 | 64% | 7-0 | 1.80 | 0.92 |
| 2006-08-04 | John Lackey | R | 28 | W 3-7 | vs TEX | 23 | 139 | L | 4.1 | 6 | 7 | 7 | 1 | 6 | 2 | 96 | 45 | 51 | 53% | 10-7 | 3.27 | 1.14 |
| 2006-08-05 | Ervin Santana | R | 24 | L 10-3 | vs TEX | 23 | 46 | W | 8.0 | 5 | 3 | 2 | 0 | 3 | 5 | 102 | 39 | 63 | 62% | 12-5 | 4.10 | 1.22 |
| 2006-08-06 | Joe Saunders | L | 25 | L 9-1 | vs TEX | 3 | 5 | W | 7.0 | 3 | 0 | 0 | 0 | 2 | 6 | 101 | 37 | 64 | 63% | 3-0 | 1.29 | 0.95 |
| 2006-08-07 | Kelvim Escobar | R | 30 | W 6-3 | @ CHA | 21 | 162 | W | 6.0 | 6 | 2 | 2 | 0 | 1 | 7 | 105 | 35 | 70 | 67% | 8-9 | 3.72 | 1.34 |
| 2006-08-08 | Jered Weaver | R | 24 | W 5-4 | @ CLE | 10 | 10 | - | 5.2 | 6 | 4 | 4 | 1 | 2 | 3 | 101 | 39 | 62 | 61% | 7-0 | 2.22 | 0.97 |
| 2006-08-09 | John Lackey | R | 28 | L 0-4 | @ CLE | 24 | 140 | L | 6.0 | 9 | 4 | 3 | 0 | 3 | 6 | 105 | 36 | 69 | 66% | 10-8 | 3.32 | 1.17 |
| 2006-08-10 | Ervin Santana | R | 24 | L 2-14 | @ CLE | 24 | 47 | L | 0.1 | 1 | 1 | 1 | 0 | 0 | 1 | 4 | 1 | 3 | 75% | 12-6 | 4.14 | 1.22 |
| 2006-08-11 | Joe Saunders | L | 25 | W 7-4 | @ NYA | 4 | 6 | W | 6.0 | 6 | 3 | 2 | 0 | 2 | 4 | 102 | 40 | 62 | 61% | 4-0 | 1.67 | 1.04 |
| 2006-08-12 | Kelvim Escobar | R | 30 | L 2-5 | @ NYA | 22 | 163 | L | 6.0 | 8 | 5 | 5 | 2 | 3 | 5 | 103 | 38 | 65 | 63% | 8-10 | 3.88 | 1.36 |
| 2006-08-13 | Jered Weaver | R | 24 | W 5-3 | @ NYA | 11 | 11 | W | 6.0 | 3 | 1 | 1 | 1 | 3 | 8 | 102 | 39 | 63 | 62% | 8-0 | 2.15 | 0.97 |
| 2006-08-14 | John Lackey | R | 28 | L 2-7 | @ NYA | 25 | 141 | L | 7.0 | 11 | 3 | 3 | 1 | 4 | 4 | 105 | 36 | 69 | 66% | 10-9 | 3.34 | 1.21 |
| 2006-08-15 | Ervin Santana | R | 24 | W 9-7 | @ TEX | 25 | 48 | - | 5.0 | 7 | 6 | 6 | 3 | 2 | 3 | 103 | 37 | 66 | 64% | 12-6 | 4.35 | 1.24 |
| 2006-08-16 | Joe Saunders | L | 25 | L 3-9 | @ TEX | 5 | 7 | L | 2.2 | 5 | 8 | 7 | 1 | 5 | 1 | 73 | 34 | 39 | 53% | 4-1 | 3.60 | 1.27 |
| 2006-08-17 | Kelvim Escobar | R | 30 | L 5-2 | vs SEA | 23 | 164 | W | 7.0 | 7 | 1 | 1 | 0 | 1 | 7 | 95 | 27 | 68 | 72% | 9-10 | 3.76 | 1.35 |
| 2006-08-18 | Jered Weaver | R | 24 | L 3-0 | vs SEA | 12 | 12 | W | 7.0 | 3 | 0 | 0 | 0 | 1 | 7 | 103 | 34 | 69 | 67% | 9-0 | 1.96 | 0.94 |
| 2006-08-19 | John Lackey | R | 28 | L 9-7 | vs SEA | 26 | 142 | - | 4.2 | 12 | 5 | 5 | 1 | 1 | 7 | 104 | 33 | 71 | 68% | 10-9 | 3.53 | 1.26 |
| 2006-08-20 | Ervin Santana | R | 24 | L 3-2 | vs SEA | 26 | 49 | - | 7.0 | 4 | 2 | 2 | 1 | 5 | 6 | 118 | 47 | 71 | 60% | 12-6 | 4.28 | 1.24 |
| 2006-08-22 | Joe Saunders | L | 25 | L 4-3 | vs BOS | 6 | 8 | - | 5.2 | 6 | 2 | 0 | 0 | 3 | 4 | 98 | 42 | 56 | 57% | 4-1 | 3.09 | 1.34 |
| 2006-08-23 | Kelvim Escobar | R | 30 | W 4-5 | vs BOS | 24 | 165 | L | 8.0 | 6 | 5 | 5 | 2 | 1 | 6 | 100 | 28 | 72 | 72% | 9-11 | 3.86 | 1.32 |
| 2006-08-24 | Jered Weaver | R | 24 | W 1-2 | vs BOS | 13 | 13 | L | 6.0 | 4 | 1 | 1 | 1 | 1 | 6 | 105 | 38 | 67 | 64% | 9-1 | 1.93 | 0.93 |
| 2006-08-25 | John Lackey | R | 28 | L 6-5 | vs NYA | 27 | 143 | - | 6.0 | 10 | 4 | 4 | 0 | 3 | 7 | 106 | 41 | 65 | 61% | 10-9 | 3.61 | 1.29 |
| 2006-08-26 | Ervin Santana | R | 24 | L 12-7 | vs NYA | 27 | 50 | W | 6.1 | 7 | 5 | 4 | 0 | 3 | 5 | 109 | 41 | 68 | 62% | 13-6 | 4.34 | 1.25 |
| 2006-08-27 | Joe Saunders | L | 25 | W 8-11 | vs NYA | 7 | 9 | L | 2.1 | 7 | 8 | 8 | 3 | 3 | 3 | 74 | 28 | 46 | 62% | 4-2 | 4.74 | 1.50 |
| 2006-08-28 | Kelvim Escobar | R | 30 | L 0-2 | @ SEA | 25 | 166 | L | 8.0 | 7 | 2 | 2 | 0 | 0 | 9 | 106 | 35 | 71 | 67% | 9-12 | 3.78 | 1.30 |
| 2006-08-29 | Jered Weaver | R | 24 | L 4-6 | @ SEA | 14 | 14 | L | 4.2 | 9 | 5 | 5 | 4 | 2 | 3 | 89 | 33 | 56 | 63% | 9-2 | 2.33 | 1.00 |
| 2006-08-30 | John Lackey | R | 28 | W 5-3 | @ SEA | 28 | 144 | W | 6.1 | 9 | 3 | 3 | 0 | 0 | 4 | 112 | 41 | 71 | 63% | 11-9 | 3.62 | 1.29 |
| 2006-09-01 | Ervin Santana | R | 24 | L 0-9 | @ DET | 28 | 51 | L | 4.0 | 7 | 5 | 5 | 1 | 1 | 7 | 91 | 32 | 59 | 65% | 13-7 | 4.50 | 1.27 |
| 2006-09-02 | Joe Saunders | L | 25 | W 7-2 | @ DET | 8 | 10 | - | 7.1 | 5 | 1 | 1 | 0 | 0 | 5 | 95 | 40 | 55 | 58% | 4-2 | 4.20 | 1.38 |
| 2006-09-03 | Kelvim Escobar | R | 30 | W 2-1 | @ DET | 26 | 167 | W | 8.0 | 2 | 1 | 0 | 0 | 2 | 7 | 104 | 36 | 68 | 65% | 10-12 | 3.60 | 1.26 |
| 2006-09-04 | Jered Weaver | R | 24 | L 1-0 | vs BAL | 15 | 15 | W | 7.0 | 6 | 0 | 0 | 0 | 1 | 5 | 101 | 34 | 67 | 66% | 10-2 | 2.16 | 1.00 |
| 2006-09-05 | John Lackey | R | 28 | L 5-2 | vs BAL | 29 | 145 | - | 7.0 | 9 | 1 | 1 | 0 | 1 | 5 | 121 | 40 | 81 | 67% | 11-9 | 3.53 | 1.29 |
| 2006-09-06 | Ervin Santana | R | 24 | L 8-4 | vs BAL | 29 | 52 | W | 7.0 | 7 | 4 | 4 | 3 | 1 | 4 | 103 | 39 | 64 | 62% | 14-7 | 4.53 | 1.27 |
| 2006-09-08 | Joe Saunders | L | 25 | L 4-1 | vs TOR | 9 | 11 | W | 7.2 | 5 | 1 | 1 | 0 | 1 | 3 | 96 | 28 | 68 | 71% | 5-2 | 3.74 | 1.28 |
| 2006-09-09 | Kelvim Escobar | R | 30 | W 1-2 | vs TOR | 27 | 168 | L | 7.0 | 9 | 2 | 2 | 0 | 1 | 5 | 110 | 35 | 75 | 68% | 10-13 | 3.56 | 1.27 |
| 2006-09-10 | Jered Weaver | R | 24 | L 4-3 | vs TOR | 16 | 16 | W | 5.2 | 6 | 3 | 3 | 1 | 3 | 8 | 111 | 40 | 71 | 64% | 11-2 | 2.29 | 1.03 |
| 2006-09-11 | John Lackey | R | 28 | W 2-3 | vs CHA | 30 | 146 | L | 8.0 | 4 | 3 | 3 | 0 | 2 | 8 | 118 | 44 | 74 | 63% | 11-10 | 3.53 | 1.27 |
| 2006-09-12 | Ervin Santana | R | 24 | L 4-3 | vs CHA | 30 | 53 | - | 7.0 | 7 | 3 | 3 | 0 | 1 | 5 | 111 | 37 | 74 | 67% | 14-7 | 4.50 | 1.26 |
| 2006-09-13 | Joe Saunders | L | 25 | W 0-9 | vs CHA | 10 | 12 | L | 3.1 | 8 | 7 | 7 | 0 | 3 | 5 | 72 | 30 | 42 | 58% | 5-3 | 4.66 | 1.41 |
| 2006-09-14 | Kelvim Escobar | R | 30 | W 2-1 | @ TEX | 28 | 169 | - | 4.0 | 2 | 1 | 1 | 0 | 3 | 2 | 66 | 30 | 36 | 55% | 10-13 | 3.53 | 1.27 |
| 2006-09-15 | Jered Weaver | R | 24 | W 2-1 | @ TEX | 17 | 17 | - | 7.0 | 1 | 0 | 0 | 0 | 3 | 9 | 105 | 39 | 66 | 63% | 11-2 | 2.15 | 1.00 |
| 2006-09-16 | John Lackey | R | 28 | L 6-12 | @ TEX | 31 | 147 | L | 4.0 | 10 | 6 | 6 | 0 | 2 | 4 | 89 | 34 | 55 | 62% | 11-11 | 3.72 | 1.31 |
| 2006-09-17 | Ervin Santana | R | 24 | L 1-8 | @ TEX | 31 | 54 | L | 5.0 | 7 | 4 | 4 | 0 | 2 | 2 | 91 | 38 | 53 | 58% | 14-8 | 4.57 | 1.28 |
| 2006-09-19 | Joe Saunders | L | 25 | W 5-2 | @ KCA | 11 | 13 | W | 7.0 | 7 | 1 | 1 | 0 | 3 | 8 | 113 | 44 | 69 | 61% | 6-3 | 4.29 | 1.41 |
| 2006-09-20 | Kelvim Escobar | R | 30 | W 3-0 | @ KCA | 29 | 170 | W | 7.0 | 4 | 0 | 0 | 0 | 1 | 5 | 103 | 41 | 62 | 60% | 11-13 | 3.40 | 1.25 |
| 2006-09-22 | Jered Weaver | R | 24 | L 4-5 | @ OAK | 18 | 18 | - | 7.2 | 5 | 4 | 4 | 3 | 1 | 4 | 110 | 39 | 71 | 65% | 11-2 | 2.33 | 0.99 |
| 2006-09-23 | John Lackey | R | 28 | W 6-2 | @ OAK | 32 | 148 | W | 7.0 | 4 | 2 | 2 | 0 | 2 | 5 | 124 | 43 | 81 | 65% | 12-11 | 3.69 | 1.29 |
| 2006-09-24 | Ervin Santana | R | 24 | W 7-1 | @ OAK | 32 | 55 | W | 8.0 | 2 | 1 | 1 | 0 | 2 | 2 | 97 | 38 | 59 | 61% | 15-8 | 4.43 | 1.24 |
| 2006-09-25 | Joe Saunders | L | 25 | L 8-3 | vs TEX | 12 | 14 | W | 7.0 | 6 | 2 | 2 | 0 | 0 | 4 | 97 | 33 | 64 | 66% | 7-3 | 4.11 | 1.36 |
| 2006-09-26 | Kelvim Escobar | R | 30 | W 2-5 | vs TEX | 30 | 171 | L | 1.2 | 7 | 5 | 5 | 1 | 0 | 0 | 35 | 14 | 21 | 60% | 11-14 | 3.62 | 1.28 |
| 2006-09-27 | Jered Weaver | R | 24 | L 6-5 | vs TEX | 19 | 19 | - | 6.2 | 10 | 5 | 5 | 2 | 2 | 5 | 100 | 37 | 63 | 63% | 11-2 | 2.56 | 1.03 |
| 2006-09-28 | John Lackey | R | 28 | L 2-0 | vs OAK | 33 | 149 | W | 8.0 | 4 | 0 | 0 | 0 | 0 | 11 | 108 | 37 | 71 | 66% | 13-11 | 3.55 | 1.26 |
| 2006-09-29 | Ervin Santana | R | 24 | L 6-0 | vs OAK | 33 | 56 | W | 7.0 | 3 | 0 | 0 | 0 | 3 | 2 | 97 | 36 | 61 | 63% | 16-8 | 4.28 | 1.23 |
| 2006-09-30 | Joe Saunders | L | 25 | L 7-6 | vs OAK | 13 | 15 | - | 0.2 | 4 | 5 | 5 | 1 | 1 | 0 | 28 | 10 | 18 | 64% | 7-3 | 4.69 | 1.41 |
| 2006-10-01 | Dustin Moseley | R | 25 | W 10-11 | vs OAK | 2 | 2 | - | 4.0 | 10 | 7 | 7 | 1 | 2 | 1 | 93 | 39 | 54 | 58% | 1-0 | 9.00 | 2.18 |