| Central | W | L | Pct | GB |
| St. Louis | 100 | 62 | .617 | -- |
| Houston | 89 | 73 | .549 | 11.0 |
| Milwaukee | 81 | 81 | .500 | 19.0 |
| Chi Cubs | 79 | 83 | .488 | 21.0 |
| Cincinnati | 73 | 89 | .451 | 27.0 |
| Pittsburgh | 67 | 95 | .414 | 33.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2005-04-04 | Paul Wilson | R | 32 | L 7-6 | vs NYN | 1 | 145 | - | 6.0 | 8 | 3 | 3 | 2 | 2 | 2 | 89 | 33 | 56 | 63% | 0-0 | 4.50 | 1.67 |
| 2005-04-06 | Eric Milton | L | 30 | L 9-5 | vs NYN | 1 | 200 | W | 5.1 | 9 | 3 | 3 | 2 | 0 | 2 | 65 | 18 | 47 | 72% | 1-0 | 5.40 | 1.80 |
| 2005-04-07 | Aaron Harang | R | 27 | L 6-1 | vs NYN | 1 | 59 | W | 6.1 | 1 | 0 | 0 | 0 | 3 | 5 | 95 | 35 | 60 | 63% | 1-0 | 0.00 | 0.67 |
| 2005-04-08 | Ramon Ortiz | R | 32 | L 2-3 | @ HOU | 1 | 138 | - | 5.0 | 5 | 1 | 1 | 0 | 3 | 6 | 81 | 29 | 52 | 64% | 0-0 | 1.80 | 1.60 |
| 2005-04-09 | Paul Wilson | R | 32 | L 3-4 | @ HOU | 2 | 146 | - | 6.0 | 8 | 3 | 3 | 2 | 2 | 2 | 96 | 28 | 68 | 71% | 0-0 | 4.50 | 1.67 |
| 2005-04-10 | Eric Milton | L | 30 | L 2-5 | @ HOU | 2 | 201 | L | 4.1 | 8 | 5 | 5 | 3 | 1 | 2 | 79 | 22 | 57 | 72% | 1-1 | 7.20 | 1.80 |
| 2005-04-12 | Aaron Harang | R | 27 | L 1-5 | @ SLN | 2 | 60 | L | 6.0 | 5 | 5 | 5 | 2 | 3 | 2 | 99 | 39 | 60 | 61% | 1-1 | 3.75 | 1.00 |
| 2005-04-13 | Matt Belisle | R | 25 | W 6-5 | @ SLN | 1 | 1 | W | 5.0 | 4 | 1 | 1 | 1 | 1 | 6 | 72 | 21 | 51 | 71% | 1-1 | 3.38 | 1.25 |
| 2005-04-15 | Paul Wilson | R | 32 | W 2-11 | vs HOU | 3 | 147 | L | 5.0 | 7 | 6 | 6 | 2 | 1 | 5 | 76 | 26 | 50 | 66% | 0-1 | 6.35 | 1.65 |
| 2005-04-16 | Eric Milton | L | 30 | L 3-2 | vs HOU | 3 | 202 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 7 | 94 | 31 | 63 | 67% | 2-1 | 4.76 | 1.35 |
| 2005-04-17 | Aaron Harang | R | 27 | L 6-5 | vs HOU | 3 | 61 | - | 6.0 | 5 | 3 | 3 | 1 | 2 | 8 | 93 | 30 | 63 | 68% | 1-1 | 4.00 | 1.06 |
| 2005-04-18 | Matt Belisle | R | 25 | L 7-6 | vs CHN | 2 | 2 | - | 3.0 | 7 | 5 | 5 | 4 | 1 | 0 | 53 | 17 | 36 | 68% | 1-1 | 6.55 | 1.64 |
| 2005-04-19 | Brandon Claussen | L | 26 | W 1-7 | vs CHN | 1 | 16 | L | 5.0 | 7 | 4 | 3 | 1 | 0 | 6 | 70 | 23 | 47 | 67% | 0-1 | 5.40 | 1.40 |
| 2005-04-20 | Paul Wilson | R | 32 | L 6-4 | vs PIT | 4 | 148 | W | 7.0 | 9 | 3 | 3 | 0 | 0 | 9 | 96 | 24 | 72 | 75% | 1-1 | 5.63 | 1.54 |
| 2005-04-21 | Eric Milton | L | 30 | W 2-4 | vs PIT | 4 | 203 | L | 5.0 | 5 | 3 | 3 | 1 | 2 | 1 | 95 | 34 | 61 | 64% | 2-2 | 4.91 | 1.36 |
| 2005-04-22 | Aaron Harang | R | 27 | L 2-4 | @ FLO | 4 | 62 | - | 6.0 | 8 | 2 | 2 | 0 | 2 | 6 | 102 | 35 | 67 | 66% | 1-1 | 3.75 | 1.21 |
| 2005-04-23 | Matt Belisle | R | 25 | L 2-4 | @ FLO | 3 | 3 | L | 5.0 | 7 | 4 | 3 | 0 | 0 | 3 | 87 | 38 | 49 | 56% | 1-2 | 6.19 | 1.56 |
| 2005-04-24 | Brandon Claussen | L | 26 | W 2-1 | @ FLO | 2 | 17 | W | 5.1 | 3 | 0 | 0 | 0 | 3 | 3 | 96 | 42 | 54 | 56% | 1-1 | 2.70 | 1.30 |
| 2005-04-25 | Paul Wilson | R | 32 | L 6-10 | @ CHN | 5 | 149 | L | 6.0 | 8 | 5 | 5 | 0 | 2 | 3 | 92 | 31 | 61 | 66% | 1-2 | 6.00 | 1.57 |
| 2005-04-26 | Eric Milton | L | 30 | W 11-9 | @ CHN | 5 | 204 | - | 5.0 | 11 | 8 | 8 | 4 | 0 | 2 | 60 | 13 | 47 | 78% | 2-2 | 6.67 | 1.52 |
| 2005-04-27 | Aaron Harang | R | 27 | L 7-8 | @ CHN | 5 | 63 | - | 5.0 | 9 | 4 | 4 | 1 | 1 | 3 | 95 | 27 | 68 | 72% | 1-1 | 4.34 | 1.34 |
| 2005-04-29 | Brandon Claussen | L | 26 | L 3-4 | @ MIL | 3 | 18 | L | 4.0 | 5 | 4 | 1 | 2 | 4 | 1 | 84 | 40 | 44 | 52% | 1-2 | 2.57 | 1.57 |
| 2005-04-30 | Paul Wilson | R | 32 | L 5-6 | @ MIL | 6 | 150 | - | 6.0 | 3 | 1 | 1 | 0 | 6 | 3 | 103 | 47 | 56 | 54% | 1-2 | 5.25 | 1.56 |
| 2005-05-01 | Ramon Ortiz | R | 32 | L 3-13 | @ MIL | 2 | 139 | L | 2.0 | 7 | 6 | 6 | 1 | 1 | 1 | 60 | 22 | 38 | 63% | 0-1 | 9.00 | 2.29 |
| 2005-05-02 | Eric Milton | L | 30 | W 9-10 | vs SLN | 6 | 205 | - | 6.0 | 5 | 2 | 1 | 1 | 1 | 5 | 103 | 38 | 65 | 63% | 2-2 | 5.73 | 1.42 |
| 2005-05-03 | Aaron Harang | R | 27 | W 2-4 | vs SLN | 6 | 64 | L | 7.0 | 6 | 2 | 2 | 0 | 1 | 2 | 109 | 42 | 67 | 61% | 1-2 | 4.00 | 1.28 |
| 2005-05-04 | Brandon Claussen | L | 26 | W 3-7 | vs SLN | 4 | 19 | L | 3.1 | 10 | 7 | 7 | 1 | 0 | 1 | 66 | 18 | 48 | 73% | 1-3 | 5.50 | 1.78 |
| 2005-05-06 | Paul Wilson | R | 32 | W 6-13 | vs LAN | 7 | 151 | L | 0.0 | 5 | 8 | 8 | 2 | 1 | 0 | 25 | 12 | 13 | 52% | 1-3 | 7.25 | 1.72 |
| 2005-05-07 | Ramon Ortiz | R | 32 | L 11-3 | vs LAN | 3 | 140 | - | 5.1 | 8 | 3 | 3 | 1 | 1 | 3 | 99 | 35 | 64 | 65% | 0-1 | 7.50 | 2.08 |
| 2005-05-08 | Eric Milton | L | 30 | W 3-9 | vs LAN | 7 | 206 | L | 6.2 | 9 | 6 | 6 | 2 | 1 | 3 | 94 | 35 | 59 | 63% | 2-3 | 6.23 | 1.46 |
| 2005-05-09 | Aaron Harang | R | 27 | W 5-6 | vs SDN | 7 | 65 | - | 8.0 | 3 | 1 | 1 | 0 | 2 | 8 | 114 | 35 | 79 | 69% | 1-2 | 3.48 | 1.16 |
| 2005-05-10 | Brandon Claussen | L | 26 | L 5-1 | vs SDN | 5 | 20 | - | 3.1 | 3 | 0 | 0 | 0 | 1 | 2 | 65 | 24 | 41 | 63% | 1-3 | 4.71 | 1.71 |
| 2005-05-11 | Paul Wilson | R | 32 | W 2-7 | vs SDN | 8 | 152 | L | 5.0 | 12 | 5 | 5 | 1 | 1 | 4 | 96 | 33 | 63 | 66% | 1-4 | 7.46 | 1.83 |
| 2005-05-12 | Ramon Ortiz | R | 32 | W 7-5 | @ PHI | 4 | 141 | W | 5.0 | 8 | 3 | 3 | 1 | 5 | 0 | 92 | 42 | 50 | 54% | 1-1 | 6.88 | 2.24 |
| 2005-05-13 | Eric Milton | L | 30 | L 2-12 | @ PHI | 8 | 207 | L | 4.1 | 8 | 8 | 8 | 1 | 3 | 2 | 95 | 43 | 52 | 55% | 2-4 | 7.16 | 1.55 |
| 2005-05-14 | Aaron Harang | R | 27 | W 12-4 | @ PHI | 8 | 66 | W | 8.0 | 9 | 4 | 4 | 1 | 2 | 4 | 119 | 42 | 77 | 65% | 2-2 | 3.63 | 1.19 |
| 2005-05-15 | Elizardo Ramirez | R | 22 | L 3-4 | @ PHI | 1 | 1 | L | 6.0 | 7 | 2 | 2 | 2 | 2 | 4 | 89 | 30 | 59 | 66% | 0-1 | 3.38 | 1.63 |
| 2005-05-16 | Paul Wilson | R | 32 | L 2-9 | @ NYN | 9 | 153 | L | 5.1 | 8 | 7 | 6 | 1 | 2 | 2 | 87 | 29 | 58 | 67% | 1-5 | 7.83 | 1.85 |
| 2005-05-17 | Ramon Ortiz | R | 32 | L 1-2 | @ NYN | 5 | 142 | L | 7.0 | 6 | 2 | 2 | 1 | 1 | 2 | 90 | 29 | 61 | 68% | 1-2 | 5.63 | 1.88 |
| 2005-05-18 | Eric Milton | L | 30 | L 6-10 | @ NYN | 9 | 208 | L | 5.1 | 7 | 6 | 4 | 1 | 2 | 2 | 98 | 32 | 66 | 67% | 2-5 | 7.16 | 1.57 |
| 2005-05-20 | Aaron Harang | R | 27 | L 2-1 | vs CLE | 9 | 67 | W | 7.1 | 4 | 1 | 1 | 0 | 2 | 9 | 111 | 38 | 73 | 66% | 3-2 | 3.30 | 1.13 |
| 2005-05-21 | Elizardo Ramirez | R | 22 | W 3-5 | vs CLE | 2 | 2 | L | 7.0 | 7 | 5 | 5 | 1 | 0 | 3 | 94 | 30 | 64 | 68% | 0-2 | 4.80 | 1.33 |
| 2005-05-22 | Ramon Ortiz | R | 32 | W 2-9 | vs CLE | 6 | 143 | L | 5.2 | 10 | 3 | 3 | 1 | 0 | 2 | 85 | 28 | 57 | 67% | 1-3 | 5.40 | 1.83 |
| 2005-05-23 | Eric Milton | L | 30 | L 5-3 | vs WAS | 10 | 209 | W | 8.0 | 6 | 3 | 1 | 2 | 2 | 7 | 114 | 32 | 82 | 72% | 3-5 | 6.32 | 1.49 |
| 2005-05-24 | Brandon Claussen | L | 26 | L 4-3 | vs WAS | 6 | 21 | - | 6.0 | 7 | 2 | 2 | 0 | 4 | 4 | 107 | 47 | 60 | 56% | 1-3 | 4.33 | 1.74 |
| 2005-05-25 | Matt Belisle | R | 25 | L 12-3 | vs WAS | 4 | 4 | W | 6.0 | 5 | 2 | 2 | 1 | 2 | 6 | 85 | 30 | 55 | 65% | 2-4 | 4.63 | 1.46 |
| 2005-05-26 | Elizardo Ramirez | R | 22 | W 4-8 | vs PIT | 3 | 3 | L | 2.2 | 8 | 6 | 6 | 1 | 3 | 1 | 57 | 27 | 30 | 53% | 0-3 | 7.00 | 1.72 |
| 2005-05-27 | Ramon Ortiz | R | 32 | L 6-5 | vs PIT | 7 | 144 | - | 6.1 | 10 | 3 | 3 | 1 | 1 | 4 | 96 | 28 | 68 | 71% | 1-3 | 5.25 | 1.83 |
| 2005-05-28 | Eric Milton | L | 30 | W 2-9 | vs PIT | 11 | 210 | L | 3.0 | 9 | 7 | 7 | 3 | 1 | 3 | 57 | 16 | 41 | 72% | 3-6 | 7.05 | 1.58 |
| 2005-05-29 | Brandon Claussen | L | 26 | L 11-2 | vs PIT | 7 | 22 | W | 7.2 | 7 | 2 | 2 | 1 | 3 | 4 | 112 | 42 | 70 | 63% | 2-3 | 3.86 | 1.63 |
| 2005-05-30 | Aaron Harang | R | 27 | W 9-0 | @ HOU | 10 | 68 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 10 | 115 | 42 | 73 | 63% | 4-2 | 2.96 | 1.10 |
| 2005-05-31 | Matt Belisle | R | 25 | L 3-4 | @ HOU | 5 | 5 | L | 5.0 | 6 | 3 | 3 | 0 | 2 | 2 | 70 | 30 | 40 | 57% | 2-5 | 4.73 | 1.48 |
| 2005-06-01 | Ramon Ortiz | R | 32 | L 1-4 | @ HOU | 8 | 145 | L | 6.2 | 6 | 4 | 4 | 1 | 2 | 7 | 110 | 43 | 67 | 61% | 1-4 | 5.23 | 1.72 |
| 2005-06-03 | Eric Milton | L | 30 | L 4-12 | @ COL | 12 | 211 | L | 5.0 | 8 | 4 | 4 | 1 | 4 | 2 | 112 | 48 | 64 | 57% | 3-7 | 7.06 | 1.65 |
| 2005-06-04 | Aaron Harang | R | 27 | L 5-7 | @ COL | 11 | 69 | L | 5.2 | 7 | 6 | 6 | 0 | 2 | 7 | 99 | 37 | 62 | 63% | 4-3 | 3.50 | 1.15 |
| 2005-06-05 | Brandon Claussen | L | 26 | L 6-8 | @ COL | 8 | 23 | - | 5.1 | 8 | 5 | 5 | 1 | 2 | 5 | 89 | 28 | 61 | 69% | 2-3 | 4.50 | 1.68 |
| 2005-06-07 | Ramon Ortiz | R | 32 | L 9-7 | vs TBA | 9 | 146 | - | 1.2 | 7 | 6 | 6 | 1 | 2 | 1 | 53 | 24 | 29 | 55% | 1-4 | 6.20 | 1.84 |
| 2005-06-08 | Eric Milton | L | 30 | L 11-9 | vs TBA | 13 | 212 | - | 5.0 | 8 | 7 | 7 | 1 | 2 | 3 | 89 | 32 | 57 | 64% | 3-7 | 7.46 | 1.67 |
| 2005-06-09 | Luke Hudson | R | 28 | L 14-5 | vs TBA | 1 | 10 | W | 6.0 | 3 | 5 | 5 | 2 | 4 | 0 | 91 | 40 | 51 | 56% | 1-0 | 7.50 | 1.17 |
| 2005-06-10 | Aaron Harang | R | 27 | W 3-4 | vs BAL | 12 | 70 | L | 7.0 | 5 | 3 | 3 | 1 | 2 | 10 | 126 | 36 | 90 | 71% | 4-4 | 3.53 | 1.14 |
| 2005-06-11 | Brandon Claussen | L | 26 | L 10-1 | vs BAL | 9 | 24 | W | 8.0 | 3 | 1 | 1 | 1 | 1 | 5 | 106 | 32 | 74 | 70% | 3-3 | 3.94 | 1.48 |
| 2005-06-12 | Ramon Ortiz | R | 32 | L 10-6 | vs BAL | 10 | 147 | W | 7.0 | 6 | 4 | 4 | 2 | 2 | 2 | 92 | 31 | 61 | 66% | 2-4 | 6.06 | 1.75 |
| 2005-06-13 | Eric Milton | L | 30 | L 3-10 | @ BOS | 14 | 213 | L | 5.2 | 11 | 9 | 9 | 0 | 2 | 3 | 102 | 34 | 68 | 67% | 3-8 | 7.93 | 1.71 |
| 2005-06-14 | Luke Hudson | R | 28 | L 0-7 | @ BOS | 2 | 11 | L | 5.0 | 4 | 3 | 3 | 0 | 3 | 5 | 80 | 30 | 50 | 63% | 1-1 | 6.55 | 1.27 |
| 2005-06-15 | Aaron Harang | R | 27 | L 1-6 | @ BOS | 13 | 71 | L | 4.2 | 9 | 5 | 5 | 0 | 3 | 7 | 110 | 49 | 61 | 55% | 4-5 | 3.86 | 1.21 |
| 2005-06-16 | Brandon Claussen | L | 26 | W 2-5 | vs ATL | 10 | 25 | L | 5.2 | 9 | 3 | 3 | 2 | 2 | 9 | 106 | 40 | 66 | 62% | 3-4 | 4.00 | 1.52 |
| 2005-06-17 | Ramon Ortiz | R | 32 | W 5-10 | vs ATL | 11 | 148 | L | 5.0 | 7 | 6 | 6 | 4 | 1 | 4 | 83 | 27 | 56 | 67% | 2-5 | 6.47 | 1.74 |
| 2005-06-18 | Eric Milton | L | 30 | W 1-6 | vs ATL | 15 | 214 | L | 6.0 | 9 | 4 | 4 | 3 | 1 | 2 | 99 | 31 | 68 | 69% | 3-9 | 7.79 | 1.71 |
| 2005-06-19 | Luke Hudson | R | 28 | L 11-8 | vs ATL | 3 | 12 | - | 5.0 | 4 | 2 | 2 | 1 | 6 | 2 | 102 | 44 | 58 | 57% | 1-1 | 5.63 | 1.50 |
| 2005-06-20 | Aaron Harang | R | 27 | W 1-6 | vs SLN | 14 | 72 | L | 6.1 | 8 | 5 | 5 | 1 | 3 | 5 | 117 | 38 | 79 | 68% | 4-6 | 4.10 | 1.26 |
| 2005-06-21 | Brandon Claussen | L | 26 | L 11-4 | vs SLN | 11 | 26 | W | 6.0 | 7 | 4 | 3 | 0 | 2 | 0 | 109 | 45 | 64 | 59% | 4-4 | 4.05 | 1.52 |
| 2005-06-22 | Ramon Ortiz | R | 32 | L 7-6 | vs SLN | 12 | 149 | W | 7.0 | 5 | 3 | 3 | 1 | 3 | 5 | 99 | 37 | 62 | 63% | 3-5 | 6.19 | 1.67 |
| 2005-06-24 | Eric Milton | L | 30 | W 5-4 | @ CLE | 16 | 215 | - | 6.0 | 6 | 4 | 4 | 2 | 4 | 5 | 105 | 43 | 62 | 59% | 3-9 | 7.67 | 1.70 |
| 2005-06-25 | Luke Hudson | R | 28 | L 7-12 | @ CLE | 4 | 13 | L | 2.1 | 8 | 7 | 7 | 3 | 2 | 0 | 57 | 22 | 35 | 61% | 1-2 | 8.50 | 1.89 |
| 2005-06-26 | Aaron Harang | R | 27 | L 3-4 | @ CLE | 15 | 73 | - | 6.0 | 6 | 3 | 3 | 0 | 3 | 4 | 118 | 40 | 78 | 66% | 4-6 | 4.13 | 1.27 |
| 2005-06-28 | Brandon Claussen | L | 26 | L 1-2 | @ SLN | 12 | 27 | L | 6.0 | 4 | 2 | 2 | 1 | 1 | 6 | 93 | 32 | 61 | 66% | 4-5 | 3.95 | 1.45 |
| 2005-06-29 | Ramon Ortiz | R | 32 | L 3-11 | @ SLN | 13 | 150 | L | 2.0 | 4 | 6 | 4 | 2 | 3 | 1 | 57 | 23 | 34 | 60% | 3-6 | 6.55 | 1.73 |
| 2005-06-30 | Eric Milton | L | 30 | L 2-2 | vs HOU | 17 | 216 | - | 6.0 | 5 | 2 | 2 | 0 | 2 | 5 | 88 | 26 | 62 | 70% | 3-9 | 7.37 | 1.67 |
| 2005-07-01 | Luke Hudson | R | 28 | W 7-10 | vs HOU | 5 | 14 | L | 2.0 | 6 | 6 | 6 | 1 | 2 | 3 | 52 | 25 | 27 | 52% | 1-3 | 10.35 | 2.10 |
| 2005-07-02 | Aaron Harang | R | 27 | W 3-4 | vs HOU | 16 | 74 | L | 7.0 | 8 | 4 | 4 | 1 | 1 | 4 | 106 | 28 | 78 | 74% | 4-7 | 4.19 | 1.27 |
| 2005-07-02 | Ramon Ortiz | R | 32 | L 11-6 | vs HOU | 14 | 151 | W | 6.2 | 8 | 6 | 5 | 1 | 1 | 4 | 98 | 33 | 65 | 66% | 4-6 | 6.63 | 1.71 |
| 2005-07-03 | Brandon Claussen | L | 26 | W 0-9 | vs HOU | 13 | 28 | L | 6.0 | 5 | 4 | 0 | 0 | 1 | 4 | 102 | 37 | 65 | 64% | 4-6 | 3.63 | 1.42 |
| 2005-07-04 | Elizardo Ramirez | R | 22 | W 11-10 | @ SFN | 4 | 4 | - | 3.2 | 8 | 7 | 7 | 1 | 2 | 0 | 76 | 26 | 50 | 66% | 0-3 | 8.59 | 1.95 |
| 2005-07-05 | Eric Milton | L | 30 | W 7-4 | @ SFN | 18 | 217 | W | 6.1 | 6 | 3 | 3 | 1 | 1 | 3 | 99 | 32 | 67 | 68% | 4-9 | 7.20 | 1.64 |
| 2005-07-06 | Luke Hudson | R | 28 | L 2-7 | @ SFN | 6 | 15 | L | 4.1 | 6 | 4 | 4 | 0 | 1 | 1 | 71 | 28 | 43 | 61% | 1-4 | 9.72 | 1.96 |
| 2005-07-07 | Aaron Harang | R | 27 | L 1-5 | @ SFN | 17 | 75 | L | 6.0 | 4 | 3 | 2 | 1 | 1 | 8 | 84 | 23 | 61 | 73% | 4-8 | 4.13 | 1.25 |
| 2005-07-08 | Ramon Ortiz | R | 32 | W 4-3 | @ ARI | 15 | 152 | - | 7.0 | 6 | 3 | 3 | 2 | 3 | 2 | 106 | 40 | 66 | 62% | 4-6 | 6.38 | 1.67 |
| 2005-07-09 | Brandon Claussen | L | 26 | W 6-2 | @ ARI | 14 | 29 | - | 5.2 | 7 | 2 | 2 | 0 | 0 | 4 | 101 | 34 | 67 | 66% | 4-6 | 3.62 | 1.42 |
| 2005-07-10 | Eric Milton | L | 30 | L 0-2 | @ ARI | 19 | 218 | L | 6.2 | 5 | 2 | 2 | 1 | 0 | 8 | 107 | 30 | 77 | 72% | 4-10 | 6.90 | 1.58 |
| 2005-07-15 | Aaron Harang | R | 27 | L 4-3 | vs COL | 18 | 76 | W | 7.0 | 3 | 1 | 1 | 0 | 1 | 7 | 106 | 33 | 73 | 69% | 5-8 | 3.96 | 1.21 |
| 2005-07-16 | Eric Milton | L | 30 | L 7-6 | vs COL | 20 | 219 | - | 5.0 | 7 | 4 | 4 | 0 | 1 | 5 | 89 | 28 | 61 | 69% | 4-10 | 6.91 | 1.58 |
| 2005-07-17 | Ramon Ortiz | R | 32 | L 9-4 | vs COL | 16 | 153 | W | 6.1 | 8 | 4 | 4 | 2 | 1 | 6 | 96 | 30 | 66 | 69% | 5-6 | 6.28 | 1.64 |
| 2005-07-18 | Brandon Claussen | L | 26 | W 4-9 | vs CHN | 15 | 30 | L | 3.2 | 9 | 7 | 7 | 5 | 2 | 2 | 66 | 21 | 45 | 68% | 4-7 | 4.22 | 1.48 |
| 2005-07-19 | Luke Hudson | R | 28 | W 3-7 | vs CHN | 7 | 16 | L | 4.0 | 6 | 5 | 5 | 1 | 3 | 2 | 84 | 37 | 47 | 56% | 1-5 | 9.93 | 2.00 |
| 2005-07-20 | Aaron Harang | R | 27 | L 9-3 | vs CHN | 19 | 77 | W | 9.0 | 7 | 3 | 3 | 2 | 0 | 1 | 98 | 32 | 66 | 67% | 6-8 | 3.89 | 1.18 |
| 2005-07-21 | Eric Milton | L | 30 | L 9-6 | vs CHN | 21 | 220 | - | 4.0 | 11 | 5 | 5 | 1 | 1 | 1 | 83 | 32 | 51 | 61% | 4-10 | 7.06 | 1.63 |
| 2005-07-22 | Ramon Ortiz | R | 32 | L 11-6 | vs MIL | 17 | 154 | W | 7.0 | 7 | 3 | 3 | 0 | 0 | 5 | 99 | 32 | 67 | 68% | 6-6 | 6.10 | 1.59 |
| 2005-07-23 | Brandon Claussen | L | 26 | W 7-11 | vs MIL | 16 | 31 | L | 3.2 | 6 | 9 | 9 | 3 | 3 | 4 | 88 | 40 | 48 | 55% | 4-8 | 4.98 | 1.52 |
| 2005-07-24 | Luke Hudson | R | 28 | L 3-2 | vs MIL | 8 | 17 | - | 6.0 | 6 | 2 | 2 | 0 | 3 | 4 | 99 | 43 | 56 | 57% | 1-5 | 8.74 | 1.91 |
| 2005-07-25 | Aaron Harang | R | 27 | L 0-4 | @ LAN | 20 | 78 | L | 6.0 | 7 | 4 | 4 | 0 | 2 | 3 | 105 | 34 | 71 | 68% | 6-9 | 3.98 | 1.19 |
| 2005-07-26 | Eric Milton | L | 30 | L 4-7 | @ LAN | 22 | 221 | L | 6.0 | 5 | 4 | 4 | 1 | 3 | 4 | 96 | 34 | 62 | 65% | 4-11 | 7.01 | 1.61 |
| 2005-07-27 | Ramon Ortiz | R | 32 | W 7-6 | @ LAN | 18 | 155 | - | 6.0 | 5 | 4 | 1 | 1 | 1 | 1 | 82 | 33 | 49 | 60% | 6-6 | 5.82 | 1.56 |
| 2005-07-28 | Brandon Claussen | L | 26 | W 6-1 | @ LAN | 17 | 32 | W | 7.0 | 4 | 1 | 1 | 1 | 0 | 5 | 103 | 41 | 62 | 60% | 5-8 | 4.70 | 1.45 |
| 2005-07-29 | Luke Hudson | R | 28 | W 8-3 | @ SDN | 9 | 18 | W | 5.0 | 5 | 3 | 3 | 0 | 4 | 4 | 94 | 44 | 50 | 53% | 2-5 | 8.33 | 1.90 |
| 2005-07-30 | Aaron Harang | R | 27 | W 9-1 | @ SDN | 21 | 79 | W | 8.0 | 7 | 1 | 1 | 0 | 1 | 4 | 113 | 39 | 74 | 65% | 7-9 | 3.82 | 1.18 |
| 2005-07-31 | Eric Milton | L | 30 | W 7-1 | @ SDN | 23 | 222 | W | 7.0 | 4 | 0 | 0 | 0 | 0 | 6 | 105 | 38 | 67 | 64% | 5-11 | 6.63 | 1.56 |
| 2005-08-02 | Ramon Ortiz | R | 32 | W 2-12 | vs ATL | 19 | 156 | L | 1.1 | 8 | 6 | 6 | 0 | 2 | 0 | 40 | 17 | 23 | 58% | 6-7 | 6.30 | 1.64 |
| 2005-08-03 | Brandon Claussen | L | 26 | L 8-5 | vs ATL | 18 | 33 | W | 6.2 | 7 | 5 | 5 | 1 | 0 | 5 | 107 | 32 | 75 | 70% | 6-8 | 4.87 | 1.43 |
| 2005-08-04 | Aaron Harang | R | 27 | W 4-7 | vs ATL | 22 | 80 | L | 6.0 | 8 | 4 | 4 | 1 | 3 | 1 | 101 | 38 | 63 | 62% | 7-10 | 3.91 | 1.21 |
| 2005-08-05 | Eric Milton | L | 30 | W 1-5 | vs FLO | 24 | 223 | L | 4.2 | 5 | 5 | 5 | 2 | 4 | 4 | 101 | 46 | 55 | 54% | 5-12 | 6.77 | 1.58 |
| 2005-08-06 | Luke Hudson | R | 28 | L 4-3 | vs FLO | 10 | 19 | W | 6.0 | 4 | 3 | 3 | 0 | 2 | 5 | 82 | 30 | 52 | 63% | 3-5 | 7.83 | 1.78 |
| 2005-08-07 | Ramon Ortiz | R | 32 | W 0-2 | vs FLO | 20 | 157 | L | 7.0 | 10 | 2 | 0 | 0 | 1 | 2 | 92 | 36 | 56 | 61% | 6-8 | 5.89 | 1.64 |
| 2005-08-08 | Brandon Claussen | L | 26 | W 9-4 | @ CHN | 19 | 34 | W | 7.0 | 2 | 0 | 0 | 0 | 5 | 3 | 105 | 40 | 65 | 62% | 7-8 | 4.54 | 1.40 |
| 2005-08-09 | Aaron Harang | R | 27 | W 8-3 | @ CHN | 23 | 81 | W | 7.0 | 8 | 3 | 3 | 1 | 0 | 3 | 105 | 30 | 75 | 71% | 8-10 | 3.91 | 1.20 |
| 2005-08-10 | Eric Milton | L | 30 | W 8-2 | @ CHN | 25 | 224 | W | 7.0 | 4 | 1 | 1 | 1 | 1 | 3 | 98 | 29 | 69 | 70% | 6-12 | 6.49 | 1.54 |
| 2005-08-12 | Luke Hudson | R | 28 | W 5-3 | @ MIL | 11 | 20 | W | 6.0 | 5 | 3 | 3 | 2 | 5 | 3 | 101 | 46 | 55 | 54% | 4-5 | 7.44 | 1.77 |
| 2005-08-13 | Ramon Ortiz | R | 32 | W 4-1 | @ MIL | 21 | 158 | W | 6.0 | 2 | 1 | 1 | 0 | 2 | 3 | 82 | 29 | 53 | 65% | 7-8 | 5.65 | 1.58 |
| 2005-08-14 | Brandon Claussen | L | 26 | L 3-8 | @ MIL | 20 | 35 | - | 6.0 | 6 | 3 | 3 | 0 | 1 | 4 | 106 | 40 | 66 | 62% | 7-8 | 4.54 | 1.39 |
| 2005-08-15 | Aaron Harang | R | 27 | W 3-7 | vs SFN | 24 | 82 | L | 5.0 | 9 | 4 | 2 | 2 | 2 | 7 | 102 | 31 | 71 | 70% | 8-11 | 3.90 | 1.24 |
| 2005-08-16 | Eric Milton | L | 30 | W 8-10 | vs SFN | 26 | 225 | - | 5.0 | 12 | 7 | 6 | 1 | 0 | 1 | 93 | 27 | 66 | 71% | 6-12 | 6.64 | 1.57 |
| 2005-08-17 | Luke Hudson | R | 28 | W 2-3 | vs SFN | 12 | 21 | L | 4.2 | 4 | 3 | 3 | 0 | 3 | 3 | 68 | 28 | 40 | 59% | 4-6 | 7.39 | 1.77 |
| 2005-08-18 | Ramon Ortiz | R | 32 | L 4-2 | vs SFN | 22 | 159 | W | 7.2 | 9 | 2 | 2 | 1 | 1 | 5 | 98 | 32 | 66 | 67% | 8-8 | 5.43 | 1.56 |
| 2005-08-19 | Brandon Claussen | L | 26 | L 17-3 | vs ARI | 21 | 36 | W | 6.2 | 4 | 3 | 3 | 0 | 4 | 6 | 114 | 48 | 66 | 58% | 8-8 | 4.50 | 1.37 |
| 2005-08-20 | Aaron Harang | R | 27 | W 2-6 | vs ARI | 25 | 83 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 3 | 109 | 41 | 68 | 62% | 8-11 | 3.79 | 1.23 |
| 2005-08-21 | Eric Milton | L | 30 | L 13-6 | vs ARI | 27 | 226 | W | 6.0 | 6 | 2 | 2 | 0 | 2 | 4 | 104 | 34 | 70 | 67% | 7-12 | 6.50 | 1.56 |
| 2005-08-23 | Luke Hudson | R | 28 | W 6-2 | @ WAS | 13 | 22 | W | 7.0 | 4 | 2 | 2 | 2 | 0 | 5 | 107 | 38 | 69 | 64% | 5-6 | 6.86 | 1.63 |
| 2005-08-24 | Ramon Ortiz | R | 32 | L 3-5 | @ WAS | 23 | 160 | L | 6.0 | 6 | 2 | 2 | 1 | 2 | 4 | 97 | 33 | 64 | 66% | 8-9 | 5.31 | 1.55 |
| 2005-08-25 | Brandon Claussen | L | 26 | W 5-3 | @ WAS | 22 | 37 | W | 5.2 | 6 | 1 | 0 | 0 | 2 | 5 | 99 | 33 | 66 | 67% | 9-8 | 4.28 | 1.37 |
| 2005-08-26 | Aaron Harang | R | 27 | W 6-1 | @ PIT | 26 | 84 | W | 7.0 | 7 | 1 | 1 | 0 | 1 | 5 | 118 | 35 | 83 | 70% | 9-11 | 3.68 | 1.22 |
| 2005-08-27 | Eric Milton | L | 30 | W 4-2 | @ PIT | 28 | 227 | - | 8.0 | 6 | 1 | 1 | 1 | 1 | 7 | 118 | 39 | 79 | 67% | 7-12 | 6.23 | 1.52 |
| 2005-08-28 | Luke Hudson | R | 28 | W 7-2 | @ PIT | 14 | 23 | W | 6.0 | 3 | 1 | 1 | 0 | 4 | 7 | 99 | 48 | 51 | 52% | 6-6 | 6.39 | 1.59 |
| 2005-08-30 | Ramon Ortiz | R | 32 | L 2-5 | @ HOU | 24 | 161 | L | 6.0 | 8 | 5 | 5 | 1 | 1 | 4 | 99 | 31 | 68 | 69% | 8-10 | 5.41 | 1.55 |
| 2005-08-31 | Brandon Claussen | L | 26 | L 0-10 | @ HOU | 23 | 38 | L | 5.2 | 8 | 4 | 4 | 1 | 0 | 3 | 98 | 32 | 66 | 67% | 9-9 | 4.40 | 1.38 |
| 2005-09-01 | Aaron Harang | R | 27 | L 1-3 | @ HOU | 27 | 85 | L | 7.0 | 5 | 3 | 3 | 1 | 2 | 3 | 100 | 32 | 68 | 68% | 9-12 | 3.69 | 1.21 |
| 2005-09-02 | Eric Milton | L | 30 | L 4-7 | @ ATL | 29 | 228 | L | 3.1 | 7 | 7 | 6 | 1 | 1 | 5 | 71 | 24 | 47 | 66% | 7-13 | 6.40 | 1.53 |
| 2005-09-03 | Luke Hudson | R | 28 | L 3-9 | @ ATL | 15 | 24 | L | 3.0 | 5 | 5 | 5 | 1 | 2 | 0 | 59 | 30 | 29 | 49% | 6-7 | 6.75 | 1.63 |
| 2005-09-04 | Ramon Ortiz | R | 32 | W 8-3 | @ ATL | 25 | 162 | - | 7.2 | 3 | 2 | 2 | 2 | 3 | 6 | 97 | 31 | 66 | 68% | 8-10 | 5.27 | 1.51 |
| 2005-09-05 | Brandon Claussen | L | 26 | W 1-6 | vs MIL | 24 | 39 | - | 7.0 | 7 | 1 | 1 | 0 | 2 | 6 | 114 | 44 | 70 | 61% | 9-9 | 4.24 | 1.38 |
| 2005-09-06 | Aaron Harang | R | 27 | L 2-1 | vs MIL | 28 | 86 | - | 6.2 | 8 | 1 | 1 | 0 | 3 | 7 | 130 | 47 | 83 | 64% | 9-12 | 3.60 | 1.23 |
| 2005-09-07 | Eric Milton | L | 30 | W 5-14 | vs MIL | 30 | 229 | L | 3.0 | 10 | 6 | 6 | 2 | 2 | 4 | 75 | 29 | 46 | 61% | 7-14 | 6.61 | 1.58 |
| 2005-09-09 | Luke Hudson | R | 28 | W 4-8 | vs PIT | 16 | 25 | L | 2.2 | 5 | 6 | 6 | 1 | 3 | 3 | 64 | 34 | 30 | 47% | 6-8 | 7.20 | 1.67 |
| 2005-09-10 | Ramon Ortiz | R | 32 | L 6-2 | vs PIT | 26 | 163 | W | 9.0 | 8 | 2 | 2 | 0 | 2 | 6 | 119 | 37 | 82 | 69% | 9-10 | 5.07 | 1.49 |
| 2005-09-11 | Brandon Claussen | L | 26 | L 5-3 | vs PIT | 25 | 40 | - | 6.0 | 5 | 1 | 1 | 0 | 4 | 3 | 112 | 37 | 75 | 67% | 9-9 | 4.12 | 1.38 |
| 2005-09-12 | Aaron Harang | R | 27 | W 5-2 | @ CHN | 29 | 87 | W | 8.1 | 8 | 2 | 2 | 1 | 0 | 5 | 108 | 23 | 85 | 79% | 10-12 | 3.54 | 1.22 |
| 2005-09-13 | Eric Milton | L | 30 | L 3-4 | @ CHN | 31 | 230 | - | 6.0 | 6 | 3 | 3 | 1 | 2 | 2 | 116 | 49 | 67 | 58% | 7-14 | 6.54 | 1.57 |
| 2005-09-14 | Randy Keisler | L | 30 | W 7-4 | @ CHN | 1 | 14 | - | 5.0 | 4 | 3 | 3 | 1 | 4 | 5 | 77 | 33 | 44 | 57% | 2-0 | 6.49 | 1.44 |
| 2005-09-16 | Brandon Claussen | L | 26 | W 8-2 | @ PIT | 26 | 41 | W | 7.0 | 6 | 1 | 1 | 0 | 2 | 6 | 109 | 38 | 71 | 65% | 10-9 | 3.99 | 1.37 |
| 2005-09-16 | Ramon Ortiz | R | 32 | L 4-5 | @ PIT | 27 | 164 | - | 6.0 | 9 | 2 | 2 | 0 | 1 | 5 | 93 | 33 | 60 | 65% | 9-10 | 4.99 | 1.50 |
| 2005-09-17 | Aaron Harang | R | 27 | L 0-4 | @ PIT | 30 | 88 | L | 6.0 | 7 | 4 | 4 | 2 | 0 | 5 | 98 | 35 | 63 | 64% | 10-13 | 3.62 | 1.22 |
| 2005-09-18 | Eric Milton | L | 30 | L 7-9 | @ PIT | 32 | 231 | - | 0.2 | 6 | 6 | 6 | 0 | 2 | 0 | 37 | 18 | 19 | 51% | 7-14 | 6.85 | 1.62 |
| 2005-09-20 | Randy Keisler | L | 30 | L 6-5 | vs SLN | 2 | 15 | - | 5.0 | 4 | 5 | 0 | 1 | 4 | 3 | 85 | 37 | 48 | 56% | 2-0 | 5.81 | 1.46 |
| 2005-09-21 | Ramon Ortiz | R | 32 | W 1-5 | vs SLN | 28 | 165 | L | 5.0 | 10 | 5 | 5 | 2 | 0 | 2 | 76 | 26 | 50 | 66% | 9-11 | 5.12 | 1.51 |
| 2005-09-22 | Brandon Claussen | L | 26 | L 6-2 | vs SLN | 27 | 42 | - | 7.0 | 6 | 2 | 2 | 0 | 2 | 5 | 106 | 32 | 74 | 70% | 10-9 | 3.92 | 1.36 |
| 2005-09-23 | Aaron Harang | R | 27 | W 10-11 | vs PHI | 31 | 89 | - | 5.0 | 11 | 6 | 6 | 2 | 0 | 3 | 91 | 26 | 65 | 71% | 10-13 | 3.79 | 1.24 |
| 2005-09-24 | Eric Milton | L | 30 | L 3-2 | vs PHI | 33 | 232 | W | 7.0 | 5 | 1 | 1 | 0 | 1 | 3 | 112 | 44 | 68 | 61% | 8-14 | 6.64 | 1.59 |
| 2005-09-25 | Randy Keisler | L | 30 | W 3-6 | vs PHI | 3 | 16 | L | 5.0 | 8 | 4 | 4 | 2 | 3 | 5 | 91 | 39 | 52 | 57% | 2-1 | 5.94 | 1.53 |
| 2005-09-26 | Ramon Ortiz | R | 33 | L 9-12 | @ MIL | 29 | 166 | - | 5.0 | 5 | 5 | 5 | 1 | 2 | 2 | 76 | 32 | 44 | 58% | 9-11 | 5.24 | 1.51 |
| 2005-09-27 | Brandon Claussen | L | 26 | L 2-6 | @ MIL | 28 | 43 | L | 5.1 | 6 | 5 | 4 | 1 | 5 | 5 | 114 | 45 | 69 | 61% | 10-10 | 4.00 | 1.38 |
| 2005-09-28 | Aaron Harang | R | 27 | W 11-4 | @ MIL | 32 | 90 | W | 7.1 | 14 | 4 | 4 | 1 | 1 | 4 | 113 | 36 | 77 | 68% | 11-13 | 3.82 | 1.26 |
| 2005-09-29 | Eric Milton | L | 30 | L 0-2 | @ MIL | 34 | 233 | L | 7.0 | 5 | 2 | 2 | 0 | 0 | 7 | 111 | 37 | 74 | 67% | 8-15 | 6.48 | 1.55 |
| 2005-09-30 | Randy Keisler | L | 30 | L 6-12 | @ SLN | 4 | 17 | - | 3.1 | 9 | 4 | 4 | 0 | 2 | 2 | 88 | 33 | 55 | 63% | 2-1 | 6.27 | 1.64 |
| 2005-10-01 | Ramon Ortiz | R | 33 | L 6-9 | @ SLN | 30 | 167 | - | 6.0 | 5 | 6 | 6 | 3 | 3 | 1 | 89 | 36 | 53 | 60% | 9-11 | 5.37 | 1.50 |
| 2005-10-02 | Brandon Claussen | L | 26 | L 5-7 | @ SLN | 29 | 44 | L | 5.0 | 11 | 6 | 6 | 2 | 1 | 5 | 96 | 29 | 67 | 70% | 10-11 | 4.20 | 1.41 |