| 2005-04-04 | vs NYN | 1 | W 7-6 | 1-0 | 2 | 42,794 | Paul Wilson | Pedro Martinez | Danny Graves | Braden Looper | | 7 | 6 | 1 |
| 2005-04-06 | vs NYN | 2 | W 9-5 | 2-0 | 1 | 22,301 | Eric Milton | Tom Glavine | Eric Milton | Tom Glavine | | 16 | 11 | 5 |
| 2005-04-07 | vs NYN | 3 | W 6-1 | 3-0 | 1 | 16,048 | Aaron Harang | Kazuhisa Ishii | Aaron Harang | Kazuhisa Ishii | Danny Graves | 22 | 12 | 10 |
| 2005-04-08 | @ HOU | 4 | L 2-3 | 3-1 | 2 | 36,382 | Ramon Ortiz | Roger Clemens | Roger Clemens | Matt Belisle | Brad Lidge | 24 | 15 | 9 |
| 2005-04-09 | @ HOU | 5 | L 3-4 | 3-2 | 3 | 34,502 | Paul Wilson | Brandon Backe | Brad Lidge | Ryan Wagner | | 27 | 19 | 8 |
| 2005-04-10 | @ HOU | 6 | L 2-5 | 3-3 | 4 | 31,832 | Eric Milton | Roy Oswalt | Roy Oswalt | Eric Milton | Brad Lidge | 29 | 24 | 5 |
| 2005-04-12 | @ SLN | 7 | L 1-5 | 3-4 | 5 | 33,617 | Aaron Harang | Jason Marquis | Jason Marquis | Aaron Harang | | 30 | 29 | 1 |
| 2005-04-13 | @ SLN | 8 | W 6-5 | 4-4 | 3 | 28,772 | Matt Belisle | Mark Mulder | Matt Belisle | Mark Mulder | Danny Graves | 36 | 34 | 2 |
| 2005-04-15 | vs HOU | 9 | L 2-11 | 4-5 | 4 | 31,740 | Paul Wilson | Roy Oswalt | Roy Oswalt | Paul Wilson | | 38 | 45 | -7 |
| 2005-04-16 | vs HOU | 10 | W 3-2 | 5-5 | 2 | 26,926 | Eric Milton | Andy Pettitte | Eric Milton | Andy Pettitte | Danny Graves | 41 | 47 | -6 |
| 2005-04-17 | vs HOU | 11 | W 6-5 | 6-5 | 2 | 25,762 | Aaron Harang | Brandon Duckworth | Ryan Wagner | Chad Qualls | Danny Graves | 47 | 52 | -5 |
| 2005-04-18 | vs CHN | 12 | W 7-6 | 7-5 | 2 | 25,349 | Matt Belisle | Kerry Wood | Kent Mercker | Jon Leicester | Danny Graves | 54 | 58 | -4 |
| 2005-04-19 | vs CHN | 13 | L 1-7 | 7-6 | 2 | 25,373 | Brandon Claussen | Mark Prior | Mark Prior | Brandon Claussen | | 55 | 65 | -10 |
| 2005-04-20 | vs PIT | 14 | W 6-4 | 8-6 | 2 | 16,857 | Paul Wilson | Oliver Perez | Paul Wilson | Salomon Torres | Danny Graves | 61 | 69 | -8 |
| 2005-04-21 | vs PIT | 15 | L 2-4 | 8-7 | 2 | 16,218 | Eric Milton | Kip Wells | Kip Wells | Eric Milton | Jose Mesa | 63 | 73 | -10 |
| 2005-04-22 | @ FLO | 16 | L 2-4 | 8-8 | 3 | 30,519 | Aaron Harang | A.J. Burnett | Matt Perisho | Kent Mercker | Guillermo Mota | 65 | 77 | -12 |
| 2005-04-23 | @ FLO | 17 | L 2-4 | 8-9 | 3 | 23,623 | Matt Belisle | Dontrelle Willis | Dontrelle Willis | Matt Belisle | Guillermo Mota | 67 | 81 | -14 |
| 2005-04-24 | @ FLO | 18 | W 2-1 | 9-9 | 3 | 28,219 | Brandon Claussen | Brian Moehler | Brandon Claussen | Brian Moehler | Danny Graves | 69 | 82 | -13 |
| 2005-04-25 | @ CHN | 19 | L 6-10 | 9-10 | 3 | 38,013 | Paul Wilson | Mark Prior | Mark Prior | Paul Wilson | | 75 | 92 | -17 |
| 2005-04-26 | @ CHN | 20 | W 11-9 | 10-10 | 3 | 38,113 | Eric Milton | Carlos Zambrano | David Weathers | Michael Wuertz | Danny Graves | 86 | 101 | -15 |
| 2005-04-27 | @ CHN | 21 | L 7-8 | 10-11 | 3 | 38,114 | Aaron Harang | Ryan Dempster | LaTroy Hawkins | Matt Belisle | | 93 | 109 | -16 |
| 2005-04-29 | @ MIL | 22 | L 3-4 | 10-12 | 3 | 21,332 | Brandon Claussen | Gary Glover | Gary Glover | Brandon Claussen | Derrick Turnbow | 96 | 113 | -17 |
| 2005-04-30 | @ MIL | 23 | L 5-6 | 10-13 | 3 | 23,880 | Paul Wilson | Wes Obermueller | Derrick Turnbow | Joe Valentine | | 101 | 119 | -18 |
| 2005-05-01 | @ MIL | 24 | L 3-13 | 10-14 | 5 | 23,036 | Ramon Ortiz | Doug Davis | Doug Davis | Ramon Ortiz | | 104 | 132 | -28 |
| 2005-05-02 | vs SLN | 25 | L 9-10 | 10-15 | 5 | 15,961 | Eric Milton | Chris Carpenter | Randy Flores | Danny Graves | Julian Tavarez | 113 | 142 | -29 |
| 2005-05-03 | vs SLN | 26 | L 2-4 | 10-16 | 5 | 16,512 | Aaron Harang | Jason Marquis | Jason Marquis | Aaron Harang | Alberto Reyes | 115 | 146 | -31 |
| 2005-05-04 | vs SLN | 27 | L 3-7 | 10-17 | 6 | 17,241 | Brandon Claussen | Mark Mulder | Mark Mulder | Brandon Claussen | | 118 | 153 | -35 |
| 2005-05-06 | vs LAN | 28 | L 6-13 | 10-18 | 6 | 29,409 | Paul Wilson | Brad Penny | Brad Penny | Paul Wilson | | 124 | 166 | -42 |
| 2005-05-07 | vs LAN | 29 | W 11-3 | 11-18 | 5 | 26,324 | Ramon Ortiz | Derek Lowe | David Weathers | Derek Lowe | | 135 | 169 | -34 |
| 2005-05-08 | vs LAN | 30 | L 3-9 | 11-19 | 5 | 19,643 | Eric Milton | Jeff Weaver | Jeff Weaver | Eric Milton | | 138 | 178 | -40 |
| 2005-05-09 | vs SDN | 31 | L 5-6 | 11-20 | 6 | 16,095 | Aaron Harang | Jake Peavy | Chris Hammond | Matt Belisle | Trevor Hoffman | 143 | 184 | -41 |
| 2005-05-10 | vs SDN | 32 | W 5-1 | 12-20 | 5 | 15,262 | Brandon Claussen | Brian Lawrence | Todd Coffey | Brian Lawrence | | 148 | 185 | -37 |
| 2005-05-11 | vs SDN | 33 | L 2-7 | 12-21 | 5 | 19,835 | Paul Wilson | Tim Stauffer | Tim Stauffer | Paul Wilson | | 150 | 192 | -42 |
| 2005-05-12 | @ PHI | 34 | W 7-5 | 13-21 | 5 | 33,663 | Ramon Ortiz | Jon Lieber | Ramon Ortiz | Jon Lieber | Danny Graves | 157 | 197 | -40 |
| 2005-05-13 | @ PHI | 35 | L 2-12 | 13-22 | 5 | 27,071 | Eric Milton | Brett Myers | Brett Myers | Eric Milton | | 159 | 209 | -50 |
| 2005-05-14 | @ PHI | 36 | W 12-4 | 14-22 | 5 | 30,189 | Aaron Harang | Randy Wolf | Aaron Harang | Ryan Madson | | 171 | 213 | -42 |
| 2005-05-15 | @ PHI | 37 | L 3-4 | 14-23 | 5 | 41,141 | Elizardo Ramirez | Vicente Padilla | Vicente Padilla | Elizardo Ramirez | Billy Wagner | 174 | 217 | -43 |
| 2005-05-16 | @ NYN | 38 | L 2-9 | 14-24 | 6 | 19,963 | Paul Wilson | Kris Benson | Kris Benson | Paul Wilson | | 176 | 226 | -50 |
| 2005-05-17 | @ NYN | 39 | L 1-2 | 14-25 | 6 | 28,426 | Ramon Ortiz | Kazuhisa Ishii | Mike DeJean | Ramon Ortiz | Braden Looper | 177 | 228 | -51 |
| 2005-05-18 | @ NYN | 40 | L 6-10 | 14-26 | 6 | 26,607 | Eric Milton | Tom Glavine | Tom Glavine | Eric Milton | | 183 | 238 | -55 |
| 2005-05-20 | vs CLE | 41 | W 2-1 | 15-26 | 5 | 25,412 | Aaron Harang | Kevin Millwood | Aaron Harang | Kevin Millwood | Danny Graves | 185 | 239 | -54 |
| 2005-05-21 | vs CLE | 42 | L 3-5 | 15-27 | 5 | 31,083 | Elizardo Ramirez | CC Sabathia | CC Sabathia | Elizardo Ramirez | Bob Wickman | 188 | 244 | -56 |
| 2005-05-22 | vs CLE | 43 | L 2-9 | 15-28 | 5 | 21,862 | Ramon Ortiz | Cliff Lee | Cliff Lee | Ramon Ortiz | | 190 | 253 | -63 |
| 2005-05-23 | vs WAS | 44 | W 5-3 | 16-28 | 5 | 17,630 | Eric Milton | Esteban Loaiza | Eric Milton | Esteban Loaiza | David Weathers | 195 | 256 | -61 |
| 2005-05-24 | vs WAS | 45 | W 4-3 | 17-28 | 5 | 36,539 | Brandon Claussen | Livan Hernandez | Randy Keisler | Luis Ayala | | 199 | 259 | -60 |
| 2005-05-25 | vs WAS | 46 | W 12-3 | 18-28 | 5 | 20,497 | Matt Belisle | Claudio Vargas | Matt Belisle | Claudio Vargas | | 211 | 262 | -51 |
| 2005-05-26 | vs PIT | 47 | L 4-8 | 18-29 | 5 | 20,513 | Elizardo Ramirez | Oliver Perez | Oliver Perez | Elizardo Ramirez | | 215 | 270 | -55 |
| 2005-05-27 | vs PIT | 48 | W 6-5 | 19-29 | 5 | 24,370 | Ramon Ortiz | Josh Fogg | Ryan Wagner | Mike Gonzalez | | 221 | 275 | -54 |
| 2005-05-28 | vs PIT | 49 | L 2-9 | 19-30 | 5 | 30,739 | Eric Milton | David Williams | David Williams | Eric Milton | | 223 | 284 | -61 |
| 2005-05-29 | vs PIT | 50 | W 11-2 | 20-30 | 5 | 26,107 | Brandon Claussen | Kip Wells | Brandon Claussen | Kip Wells | | 234 | 286 | -52 |
| 2005-05-30 | @ HOU | 51 | W 9-0 | 21-30 | 5 | 42,097 | Aaron Harang | Roger Clemens | Aaron Harang | Roger Clemens | | 243 | 286 | -43 |
| 2005-05-31 | @ HOU | 52 | L 3-4 | 21-31 | 5 | 28,535 | Matt Belisle | Brandon Backe | Brandon Backe | Matt Belisle | Brad Lidge | 246 | 290 | -44 |
| 2005-06-01 | @ HOU | 53 | L 1-4 | 21-32 | 5 | 31,571 | Ramon Ortiz | Roy Oswalt | Roy Oswalt | Ramon Ortiz | Brad Lidge | 247 | 294 | -47 |
| 2005-06-03 | @ COL | 54 | L 4-12 | 21-33 | 5 | 20,035 | Eric Milton | Jeff Francis | Jeff Francis | Eric Milton | | 251 | 306 | -55 |
| 2005-06-04 | @ COL | 55 | L 5-7 | 21-34 | 5 | 20,561 | Aaron Harang | Jamey Wright | Jamey Wright | Aaron Harang | Brian Fuentes | 256 | 313 | -57 |
| 2005-06-05 | @ COL | 56 | L 6-8 | 21-35 | 6 | 24,426 | Brandon Claussen | Jason Jennings | Blaine Neal | Ryan Wagner | Brian Fuentes | 262 | 321 | -59 |
| 2005-06-07 | vs TBA | 57 | W 9-7 | 22-35 | 5 | 17,172 | Ramon Ortiz | Mark Hendrickson | Randy Keisler | Travis Harper | David Weathers | 271 | 328 | -57 |
| 2005-06-08 | vs TBA | 58 | W 11-9 | 23-35 | 5 | 32,019 | Eric Milton | Doug Waechter | David Weathers | Danys Baez | | 282 | 337 | -55 |
| 2005-06-09 | vs TBA | 59 | W 14-5 | 24-35 | 5 | 16,381 | Luke Hudson | Casey Fossum | Luke Hudson | Casey Fossum | | 296 | 342 | -46 |
| 2005-06-10 | vs BAL | 60 | L 3-4 | 24-36 | 6 | 24,276 | Aaron Harang | Rodrigo Lopez | Rodrigo Lopez | Aaron Harang | B.J. Ryan | 299 | 346 | -47 |
| 2005-06-11 | vs BAL | 61 | W 10-1 | 25-36 | 6 | 32,834 | Brandon Claussen | Daniel Cabrera | Brandon Claussen | Daniel Cabrera | | 309 | 347 | -38 |
| 2005-06-12 | vs BAL | 62 | W 10-6 | 26-36 | 6 | 27,530 | Ramon Ortiz | Sidney Ponson | Ramon Ortiz | Sidney Ponson | | 319 | 353 | -34 |
| 2005-06-13 | @ BOS | 63 | L 3-10 | 26-37 | 6 | 35,478 | Eric Milton | Matt Clement | Matt Clement | Eric Milton | | 322 | 363 | -41 |
| 2005-06-14 | @ BOS | 64 | L 0-7 | 26-38 | 6 | 35,387 | Luke Hudson | David Wells | David Wells | Luke Hudson | | 322 | 370 | -48 |
| 2005-06-15 | @ BOS | 65 | L 1-6 | 26-39 | 6 | 35,265 | Aaron Harang | Bronson Arroyo | Bronson Arroyo | Aaron Harang | | 323 | 376 | -53 |
| 2005-06-16 | vs ATL | 66 | L 2-5 | 26-40 | 6 | 23,362 | Brandon Claussen | John Smoltz | John Smoltz | Brandon Claussen | Chris Reitsma | 325 | 381 | -56 |
| 2005-06-17 | vs ATL | 67 | L 5-10 | 26-41 | 6 | 27,023 | Ramon Ortiz | Horacio Ramirez | Horacio Ramirez | Ramon Ortiz | | 330 | 391 | -61 |
| 2005-06-18 | vs ATL | 68 | L 1-6 | 26-42 | 6 | 41,737 | Eric Milton | Jorge Sosa | Adam Bernero | Eric Milton | | 331 | 397 | -66 |
| 2005-06-19 | vs ATL | 69 | W 11-8 | 27-42 | 6 | 28,836 | Luke Hudson | Kyle Davies | David Weathers | Adam Bernero | | 342 | 405 | -63 |
| 2005-06-20 | vs SLN | 70 | L 1-6 | 27-43 | 6 | 22,035 | Aaron Harang | Chris Carpenter | Chris Carpenter | Aaron Harang | | 343 | 411 | -68 |
| 2005-06-21 | vs SLN | 71 | W 11-4 | 28-43 | 6 | 22,268 | Brandon Claussen | Jason Marquis | Brandon Claussen | Jason Marquis | | 354 | 415 | -61 |
| 2005-06-22 | vs SLN | 72 | W 7-6 | 29-43 | 6 | 31,566 | Ramon Ortiz | Mark Mulder | Ramon Ortiz | Mark Mulder | Kent Mercker | 361 | 421 | -60 |
| 2005-06-24 | @ CLE | 73 | W 5-4 | 30-43 | 6 | 27,129 | Eric Milton | Scott Elarton | Kent Mercker | Bob Howry | David Weathers | 366 | 425 | -59 |
| 2005-06-25 | @ CLE | 74 | L 7-12 | 30-44 | 6 | 42,521 | Luke Hudson | Jake Westbrook | Jake Westbrook | Luke Hudson | | 373 | 437 | -64 |
| 2005-06-26 | @ CLE | 75 | L 3-4 | 30-45 | 6 | 29,355 | Aaron Harang | CC Sabathia | Bob Howry | David Weathers | Bob Wickman | 376 | 441 | -65 |
| 2005-06-28 | @ SLN | 76 | L 1-2 | 30-46 | 6 | 38,640 | Brandon Claussen | Mark Mulder | Mark Mulder | Brandon Claussen | Jason Isringhausen | 377 | 443 | -66 |
| 2005-06-29 | @ SLN | 77 | L 3-11 | 30-47 | 6 | 39,298 | Ramon Ortiz | Matt Morris | Matt Morris | Ramon Ortiz | | 380 | 454 | -74 |
| 2005-06-30 | vs HOU | 78 | W 2-2 | 31-47 | 6 | 19,903 | Eric Milton | Brandon Backe | | | | 382 | 456 | -74 |
| 2005-07-01 | vs HOU | 79 | L 7-10 | 31-48 | 6 | 24,923 | Luke Hudson | Andy Pettitte | Andy Pettitte | Luke Hudson | Dan Wheeler | 389 | 466 | -77 |
| 2005-07-02 | vs HOU | 80 | L 3-4 | 32-49 | 6 | 0 | Aaron Harang | Wandy Rodriguez | Wandy Rodriguez | Aaron Harang | Dan Wheeler | 392 | 470 | -78 |
| 2005-07-02 | vs HOU | 81 | W 11-6 | 32-49 | 6 | 28,236 | Ramon Ortiz | Ezequiel Astacio | Ramon Ortiz | Ezequiel Astacio | | 403 | 476 | -73 |
| 2005-07-03 | vs HOU | 82 | L 0-9 | 32-50 | 6 | 27,506 | Brandon Claussen | Roger Clemens | Roger Clemens | Brandon Claussen | | 403 | 485 | -82 |
| 2005-07-04 | @ SFN | 83 | W 11-10 | 33-50 | 6 | 40,333 | Elizardo Ramirez | Kirk Rueter | Ryan Wagner | Jeremy Accardo | Matt Belisle | 414 | 495 | -81 |
| 2005-07-05 | @ SFN | 84 | W 7-4 | 34-50 | 6 | 36,254 | Eric Milton | Noah Lowry | Eric Milton | Noah Lowry | | 421 | 499 | -78 |
| 2005-07-06 | @ SFN | 85 | L 2-7 | 34-51 | 6 | 33,666 | Luke Hudson | Kevin Correia | Kevin Correia | Luke Hudson | | 423 | 506 | -83 |
| 2005-07-07 | @ SFN | 86 | L 1-5 | 34-52 | 6 | 35,543 | Aaron Harang | Brett Tomko | Brett Tomko | Aaron Harang | | 424 | 511 | -87 |
| 2005-07-08 | @ ARI | 87 | W 4-3 | 35-52 | 6 | 23,267 | Ramon Ortiz | Brad Halsey | David Weathers | Lance Cormier | Kent Mercker | 428 | 514 | -86 |
| 2005-07-09 | @ ARI | 88 | W 6-2 | 36-52 | 6 | 27,663 | Brandon Claussen | Brandon Webb | Todd Coffey | Brandon Webb | | 434 | 516 | -82 |
| 2005-07-10 | @ ARI | 89 | L 0-2 | 36-53 | 6 | 24,414 | Eric Milton | Mike Gosling | Lance Cormier | Eric Milton | Brian Bruney | 434 | 518 | -84 |
| 2005-07-15 | vs COL | 90 | W 4-3 | 37-53 | 6 | 21,116 | Aaron Harang | Jason Jennings | Aaron Harang | Jason Jennings | David Weathers | 438 | 521 | -83 |
| 2005-07-16 | vs COL | 91 | W 7-6 | 38-53 | 6 | 28,951 | Eric Milton | Jeff Francis | Jason Standridge | Dan Miceli | David Weathers | 445 | 527 | -82 |
| 2005-07-17 | vs COL | 92 | W 9-4 | 39-53 | 6 | 20,736 | Ramon Ortiz | Jamey Wright | Ramon Ortiz | Jamey Wright | | 454 | 531 | -77 |
| 2005-07-18 | vs CHN | 93 | L 4-9 | 39-54 | 6 | 24,311 | Brandon Claussen | Jerome Williams | Jerome Williams | Brandon Claussen | | 458 | 540 | -82 |
| 2005-07-19 | vs CHN | 94 | L 3-7 | 39-55 | 6 | 24,664 | Luke Hudson | Mark Prior | Mark Prior | Luke Hudson | | 461 | 547 | -86 |
| 2005-07-20 | vs CHN | 95 | W 9-3 | 40-55 | 5 | 27,363 | Aaron Harang | Kerry Wood | Aaron Harang | Kerry Wood | | 470 | 550 | -80 |
| 2005-07-21 | vs CHN | 96 | W 9-6 | 41-55 | 5 | 36,498 | Eric Milton | Greg Maddux | Brian Shackelford | Roberto Novoa | | 479 | 556 | -77 |
| 2005-07-22 | vs MIL | 97 | W 11-6 | 42-55 | 5 | 21,370 | Ramon Ortiz | Tomo Ohka | Ramon Ortiz | Tomo Ohka | | 490 | 562 | -72 |
| 2005-07-23 | vs MIL | 98 | L 7-11 | 42-56 | 5 | 36,320 | Brandon Claussen | Victor Santos | Victor Santos | Brandon Claussen | | 497 | 573 | -76 |
| 2005-07-24 | vs MIL | 99 | W 3-2 | 43-56 | 5 | 18,856 | Luke Hudson | Doug Davis | David Weathers | Julio Santana | | 500 | 575 | -75 |
| 2005-07-25 | @ LAN | 100 | L 0-4 | 43-57 | 6 | 42,668 | Aaron Harang | Derek Lowe | Derek Lowe | Aaron Harang | | 500 | 579 | -79 |
| 2005-07-26 | @ LAN | 101 | L 4-7 | 43-58 | 6 | 42,826 | Eric Milton | Odalis Perez | Odalis Perez | Eric Milton | Yhency Brazoban | 504 | 586 | -82 |
| 2005-07-27 | @ LAN | 102 | W 7-6 | 44-58 | 6 | 47,033 | Ramon Ortiz | Jeff Weaver | Jason Standridge | Yhency Brazoban | David Weathers | 511 | 592 | -81 |
| 2005-07-28 | @ LAN | 103 | W 6-1 | 45-58 | 5 | 47,877 | Brandon Claussen | D.J. Houlton | Brandon Claussen | D.J. Houlton | | 517 | 593 | -76 |
| 2005-07-29 | @ SDN | 104 | W 8-3 | 46-58 | 5 | 37,492 | Luke Hudson | Brian Lawrence | Luke Hudson | Brian Lawrence | | 525 | 596 | -71 |
| 2005-07-30 | @ SDN | 105 | W 9-1 | 47-58 | 5 | 41,510 | Aaron Harang | Pedro Astacio | Aaron Harang | Pedro Astacio | | 534 | 597 | -63 |
| 2005-07-31 | @ SDN | 106 | W 7-1 | 48-58 | 5 | 34,060 | Eric Milton | Woody Williams | Eric Milton | Woody Williams | | 541 | 598 | -57 |
| 2005-08-02 | vs ATL | 107 | L 2-12 | 48-59 | 5 | 25,680 | Ramon Ortiz | Jorge Sosa | Jorge Sosa | Ramon Ortiz | | 543 | 610 | -67 |
| 2005-08-03 | vs ATL | 108 | W 8-5 | 49-59 | 5 | 37,157 | Brandon Claussen | Horacio Ramirez | Brandon Claussen | Horacio Ramirez | Kent Mercker | 551 | 615 | -64 |
| 2005-08-04 | vs ATL | 109 | L 4-7 | 49-60 | 5 | 23,285 | Aaron Harang | Kyle Davies | Kyle Davies | Aaron Harang | Chris Reitsma | 555 | 622 | -67 |
| 2005-08-05 | vs FLO | 110 | L 1-5 | 49-61 | 5 | 23,443 | Eric Milton | Jason Vargas | Jason Vargas | Eric Milton | | 556 | 627 | -71 |
| 2005-08-06 | vs FLO | 111 | W 4-3 | 50-61 | 5 | 35,737 | Luke Hudson | Brian Moehler | Luke Hudson | Brian Moehler | David Weathers | 560 | 630 | -70 |
| 2005-08-07 | vs FLO | 112 | L 0-2 | 50-62 | 5 | 23,297 | Ramon Ortiz | Dontrelle Willis | Dontrelle Willis | Ramon Ortiz | Todd Jones | 560 | 632 | -72 |
| 2005-08-08 | @ CHN | 113 | W 9-4 | 51-62 | 5 | 39,965 | Brandon Claussen | Jerome Williams | Brandon Claussen | Jerome Williams | | 569 | 636 | -67 |
| 2005-08-09 | @ CHN | 114 | W 8-3 | 52-62 | 5 | 38,368 | Aaron Harang | Mark Prior | Aaron Harang | Will Ohman | | 577 | 639 | -62 |
| 2005-08-10 | @ CHN | 115 | W 8-2 | 53-62 | 5 | 38,405 | Eric Milton | Rich Hill | Eric Milton | Rich Hill | | 585 | 641 | -56 |
| 2005-08-12 | @ MIL | 116 | W 5-3 | 54-62 | 5 | 24,103 | Luke Hudson | Chris Capuano | Luke Hudson | Chris Capuano | David Weathers | 590 | 644 | -54 |
| 2005-08-13 | @ MIL | 117 | W 4-1 | 55-62 | 5 | 41,282 | Ramon Ortiz | Tomo Ohka | Ramon Ortiz | Tomo Ohka | David Weathers | 594 | 645 | -51 |
| 2005-08-14 | @ MIL | 118 | L 3-8 | 55-63 | 5 | 29,262 | Brandon Claussen | Doug Davis | Kane Davis | Matt Belisle | | 597 | 653 | -56 |
| 2005-08-15 | vs SFN | 119 | L 3-7 | 55-64 | 5 | 17,777 | Aaron Harang | Kevin Correia | Kevin Correia | Aaron Harang | | 600 | 660 | -60 |
| 2005-08-16 | vs SFN | 120 | L 8-10 | 55-65 | 5 | 16,954 | Eric Milton | Jason Schmidt | Jeff Fassero | Jason Standridge | Tyler Walker | 608 | 670 | -62 |
| 2005-08-17 | vs SFN | 121 | L 2-3 | 55-66 | 5 | 19,867 | Luke Hudson | Noah Lowry | Noah Lowry | Luke Hudson | LaTroy Hawkins | 610 | 673 | -63 |
| 2005-08-18 | vs SFN | 122 | W 4-2 | 56-66 | 5 | 23,012 | Ramon Ortiz | Brett Tomko | Ramon Ortiz | Brett Tomko | David Weathers | 614 | 675 | -61 |
| 2005-08-19 | vs ARI | 123 | W 17-3 | 57-66 | 5 | 21,523 | Brandon Claussen | Russ Ortiz | Brandon Claussen | Russ Ortiz | | 631 | 678 | -47 |
| 2005-08-20 | vs ARI | 124 | L 2-6 | 57-67 | 5 | 26,109 | Aaron Harang | Javier Vazquez | Javier Vazquez | Jason Standridge | | 633 | 684 | -51 |
| 2005-08-21 | vs ARI | 125 | W 13-6 | 58-67 | 5 | 26,323 | Eric Milton | Brad Halsey | Eric Milton | Brad Halsey | | 646 | 690 | -44 |
| 2005-08-23 | @ WAS | 126 | W 6-2 | 59-67 | 5 | 35,656 | Luke Hudson | Tony Armas | Luke Hudson | Tony Armas | | 652 | 692 | -40 |
| 2005-08-24 | @ WAS | 127 | L 3-5 | 59-68 | 5 | 32,641 | Ramon Ortiz | John Patterson | John Patterson | Ramon Ortiz | Chad Cordero | 655 | 697 | -42 |
| 2005-08-25 | @ WAS | 128 | W 5-3 | 60-68 | 5 | 40,762 | Brandon Claussen | Livan Hernandez | Brandon Claussen | Livan Hernandez | David Weathers | 660 | 700 | -40 |
| 2005-08-26 | @ PIT | 129 | W 6-1 | 61-68 | 5 | 28,788 | Aaron Harang | Mark Redman | Aaron Harang | Mark Redman | | 666 | 701 | -35 |
| 2005-08-27 | @ PIT | 130 | W 4-2 | 62-68 | 4 | 23,109 | Eric Milton | Josh Fogg | David Weathers | Jose Mesa | Kent Mercker | 670 | 703 | -33 |
| 2005-08-28 | @ PIT | 131 | W 7-2 | 63-68 | 4 | 23,495 | Luke Hudson | Kip Wells | Luke Hudson | Kip Wells | Todd Coffey | 677 | 705 | -28 |
| 2005-08-30 | @ HOU | 132 | L 2-5 | 63-69 | 5 | 29,971 | Ramon Ortiz | Wandy Rodriguez | Wandy Rodriguez | Ramon Ortiz | | 679 | 710 | -31 |
| 2005-08-31 | @ HOU | 133 | L 0-10 | 63-70 | 5 | 28,639 | Brandon Claussen | Andy Pettitte | Andy Pettitte | Brandon Claussen | | 679 | 720 | -41 |
| 2005-09-01 | @ HOU | 134 | L 1-3 | 63-71 | 5 | 27,490 | Aaron Harang | Roy Oswalt | Roy Oswalt | Aaron Harang | Brad Lidge | 680 | 723 | -43 |
| 2005-09-02 | @ ATL | 135 | L 4-7 | 63-72 | 5 | 27,041 | Eric Milton | Tim Hudson | Tim Hudson | Eric Milton | Kyle Farnsworth | 684 | 730 | -46 |
| 2005-09-03 | @ ATL | 136 | L 3-9 | 63-73 | 5 | 40,212 | Luke Hudson | Jorge Sosa | Jorge Sosa | Luke Hudson | | 687 | 739 | -52 |
| 2005-09-04 | @ ATL | 137 | W 8-3 | 64-73 | 5 | 34,472 | Ramon Ortiz | Horacio Ramirez | Matt Belisle | Danny Kolb | | 695 | 742 | -47 |
| 2005-09-05 | vs MIL | 138 | L 1-6 | 64-74 | 5 | 16,144 | Brandon Claussen | Tomo Ohka | Tomo Ohka | Matt Belisle | Dana Eveland | 696 | 748 | -52 |
| 2005-09-06 | vs MIL | 139 | W 2-1 | 65-74 | 5 | 13,351 | Aaron Harang | Rick Helling | Kent Mercker | Jorge de la Rosa | | 698 | 749 | -51 |
| 2005-09-07 | vs MIL | 140 | L 5-14 | 65-75 | 5 | 15,886 | Eric Milton | Chris Capuano | Chris Capuano | Eric Milton | | 703 | 763 | -60 |
| 2005-09-09 | vs PIT | 141 | L 4-8 | 65-76 | 5 | 19,244 | Luke Hudson | Oliver Perez | Ryan Vogelsong | Luke Hudson | | 707 | 771 | -64 |
| 2005-09-10 | vs PIT | 142 | W 6-2 | 66-76 | 5 | 23,510 | Ramon Ortiz | Kip Wells | Ramon Ortiz | Kip Wells | | 713 | 773 | -60 |
| 2005-09-11 | vs PIT | 143 | W 5-3 | 67-76 | 5 | 18,529 | Brandon Claussen | Paul Maholm | Matt Belisle | John Grabow | David Weathers | 718 | 776 | -58 |
| 2005-09-12 | @ CHN | 144 | W 5-2 | 68-76 | 5 | 37,926 | Aaron Harang | Greg Maddux | Aaron Harang | Greg Maddux | David Weathers | 723 | 778 | -55 |
| 2005-09-13 | @ CHN | 145 | L 3-4 | 68-77 | 5 | 37,625 | Eric Milton | Carlos Zambrano | Michael Wuertz | David Weathers | | 726 | 782 | -56 |
| 2005-09-14 | @ CHN | 146 | W 7-4 | 69-77 | 5 | 37,695 | Randy Keisler | Jerome Williams | Todd Coffey | Jermaine Van Buren | | 733 | 786 | -53 |
| 2005-09-16 | @ PIT | 147 | W 8-2 | 70-78 | 5 | 0 | Brandon Claussen | Zach Duke | Brandon Claussen | Zach Duke | | 741 | 788 | -47 |
| 2005-09-16 | @ PIT | 148 | L 4-5 | 70-78 | 5 | 22,715 | Ramon Ortiz | Kip Wells | Salomon Torres | David Weathers | | 745 | 793 | -48 |
| 2005-09-17 | @ PIT | 149 | L 0-4 | 70-79 | 5 | 31,174 | Aaron Harang | Paul Maholm | Paul Maholm | Aaron Harang | | 745 | 797 | -52 |
| 2005-09-18 | @ PIT | 150 | L 7-9 | 70-80 | 5 | 21,320 | Eric Milton | Oliver Perez | Mike Gonzalez | Matt Belisle | | 752 | 806 | -54 |
| 2005-09-20 | vs SLN | 151 | W 6-5 | 71-80 | 5 | 16,587 | Randy Keisler | Jeff Suppan | Josh Hancock | Ray King | David Weathers | 758 | 811 | -53 |
| 2005-09-21 | vs SLN | 152 | L 1-5 | 71-81 | 5 | 16,784 | Ramon Ortiz | Jason Marquis | Jason Marquis | Ramon Ortiz | | 759 | 816 | -57 |
| 2005-09-22 | vs SLN | 153 | W 6-2 | 72-81 | 5 | 17,461 | Brandon Claussen | Matt Morris | Todd Coffey | Ray King | | 765 | 818 | -53 |
| 2005-09-23 | vs PHI | 154 | L 10-11 | 72-82 | 5 | 22,608 | Aaron Harang | Vicente Padilla | Rheal Cormier | David Weathers | Billy Wagner | 775 | 829 | -54 |
| 2005-09-24 | vs PHI | 155 | W 3-2 | 73-82 | 5 | 31,632 | Eric Milton | Eude Brito | Eric Milton | Eude Brito | David Weathers | 778 | 831 | -53 |
| 2005-09-25 | vs PHI | 156 | L 3-6 | 73-83 | 5 | 23,072 | Randy Keisler | Cory Lidle | Cory Lidle | Randy Keisler | Billy Wagner | 781 | 837 | -56 |
| 2005-09-26 | @ MIL | 157 | L 9-12 | 73-84 | 5 | 14,412 | Ramon Ortiz | Tomo Ohka | Jose Capellan | Todd Coffey | Derrick Turnbow | 790 | 849 | -59 |
| 2005-09-27 | @ MIL | 158 | L 2-6 | 73-85 | 5 | 28,031 | Brandon Claussen | Rick Helling | Rick Helling | Brandon Claussen | Derrick Turnbow | 792 | 855 | -63 |
| 2005-09-28 | @ MIL | 159 | W 11-4 | 74-85 | 5 | 21,181 | Aaron Harang | Chris Capuano | Aaron Harang | Chris Capuano | | 803 | 859 | -56 |
| 2005-09-29 | @ MIL | 160 | L 0-2 | 74-86 | 5 | 13,173 | Eric Milton | Gary Glover | Gary Glover | Eric Milton | Derrick Turnbow | 803 | 861 | -58 |
| 2005-09-30 | @ SLN | 161 | L 6-12 | 74-87 | 5 | 47,257 | Randy Keisler | Mark Mulder | Alberto Reyes | Luke Hudson | | 809 | 873 | -64 |
| 2005-10-01 | @ SLN | 162 | L 6-9 | 74-88 | 5 | 49,487 | Ramon Ortiz | Jason Marquis | Randy Flores | Allan Simpson | Jason Isringhausen | 815 | 882 | -67 |
| 2005-10-02 | @ SLN | 163 | L 5-7 | 74-89 | 5 | 50,434 | Brandon Claussen | Matt Morris | Brad Thompson | Brandon Claussen | Jason Isringhausen | 820 | 889 | -69 |