| Central | W | L | Pct | GB |
| St. Louis | 100 | 62 | .617 | -- |
| Houston | 89 | 73 | .549 | 11.0 |
| Milwaukee | 81 | 81 | .500 | 19.0 |
| Chi Cubs | 79 | 83 | .488 | 21.0 |
| Cincinnati | 73 | 89 | .451 | 27.0 |
| Pittsburgh | 67 | 95 | .414 | 33.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2005-04-04 | Carlos Zambrano | R | 24 | W 16-6 | @ ARI | 1 | 81 | - | 4.2 | 7 | 3 | 3 | 1 | 4 | 8 | 106 | 49 | 57 | 54% | 0-0 | 5.40 | 2.20 |
| 2005-04-05 | Greg Maddux | R | 39 | L 4-5 | @ ARI | 1 | 605 | L | 5.0 | 6 | 5 | 5 | 2 | 1 | 6 | 85 | 36 | 49 | 58% | 0-1 | 9.00 | 1.40 |
| 2005-04-06 | Ryan Dempster | R | 28 | L 3-8 | @ ARI | 1 | 157 | L | 3.2 | 9 | 7 | 7 | 0 | 3 | 7 | 82 | 29 | 53 | 65% | 0-1 | 15.75 | 3.00 |
| 2005-04-08 | Kerry Wood | R | 28 | W 3-6 | vs MIL | 1 | 165 | - | 5.2 | 4 | 2 | 2 | 0 | 5 | 7 | 104 | 52 | 52 | 50% | 0-0 | 3.00 | 1.50 |
| 2005-04-09 | Carlos Zambrano | R | 24 | L 4-0 | vs MIL | 2 | 82 | W | 7.1 | 1 | 0 | 0 | 0 | 2 | 6 | 110 | 47 | 63 | 57% | 1-0 | 2.25 | 1.17 |
| 2005-04-10 | Greg Maddux | R | 39 | L 6-5 | vs MIL | 2 | 606 | - | 5.0 | 9 | 4 | 3 | 2 | 1 | 1 | 75 | 24 | 51 | 68% | 0-1 | 7.20 | 1.70 |
| 2005-04-11 | Ryan Dempster | R | 28 | W 0-1 | vs SDN | 2 | 158 | L | 6.0 | 4 | 1 | 0 | 0 | 3 | 7 | 104 | 43 | 61 | 59% | 0-2 | 6.30 | 1.90 |
| 2005-04-13 | Kerry Wood | R | 28 | W 3-8 | vs SDN | 2 | 166 | L | 6.2 | 9 | 7 | 6 | 3 | 2 | 6 | 111 | 41 | 70 | 63% | 0-1 | 6.00 | 1.67 |
| 2005-04-13 | Mark Prior | R | 25 | L 8-3 | vs SDN | 1 | 71 | W | 6.0 | 4 | 0 | 0 | 0 | 1 | 6 | 92 | 29 | 63 | 68% | 1-0 | 0.00 | 0.83 |
| 2005-04-15 | Carlos Zambrano | R | 24 | L 5-8 | @ PIT | 3 | 83 | - | 6.0 | 6 | 5 | 5 | 3 | 2 | 5 | 114 | 43 | 71 | 62% | 1-0 | 4.00 | 1.22 |
| 2005-04-16 | Ryan Dempster | R | 28 | W 4-3 | @ PIT | 3 | 159 | W | 6.0 | 6 | 3 | 3 | 1 | 3 | 5 | 107 | 44 | 63 | 59% | 1-2 | 5.63 | 1.75 |
| 2005-04-17 | Greg Maddux | R | 39 | W 4-2 | @ PIT | 3 | 607 | - | 6.0 | 5 | 2 | 2 | 0 | 0 | 3 | 77 | 23 | 54 | 70% | 0-1 | 5.63 | 1.38 |
| 2005-04-18 | Kerry Wood | R | 28 | L 6-7 | @ CIN | 3 | 167 | - | 6.0 | 8 | 5 | 5 | 2 | 2 | 6 | 95 | 33 | 62 | 65% | 0-1 | 6.50 | 1.67 |
| 2005-04-19 | Mark Prior | R | 25 | W 7-1 | @ CIN | 2 | 72 | W | 7.0 | 4 | 1 | 0 | 0 | 2 | 6 | 96 | 32 | 64 | 67% | 2-0 | 0.00 | 0.85 |
| 2005-04-20 | Carlos Zambrano | R | 24 | W 3-1 | @ SLN | 4 | 84 | W | 8.2 | 5 | 1 | 1 | 1 | 1 | 3 | 119 | 38 | 81 | 68% | 2-0 | 3.00 | 1.04 |
| 2005-04-21 | Ryan Dempster | R | 28 | L 0-4 | @ SLN | 4 | 160 | L | 6.0 | 4 | 1 | 1 | 0 | 3 | 4 | 95 | 39 | 56 | 59% | 1-3 | 4.50 | 1.59 |
| 2005-04-23 | Greg Maddux | R | 39 | W 3-4 | vs PIT | 4 | 608 | - | 8.0 | 4 | 2 | 2 | 0 | 1 | 3 | 94 | 33 | 61 | 65% | 0-1 | 4.50 | 1.13 |
| 2005-04-24 | Kerry Wood | R | 28 | L 5-2 | vs PIT | 4 | 168 | W | 5.0 | 3 | 2 | 2 | 0 | 3 | 8 | 76 | 31 | 45 | 59% | 1-1 | 5.87 | 1.57 |
| 2005-04-25 | Mark Prior | R | 25 | L 10-6 | vs CIN | 3 | 73 | W | 6.0 | 6 | 2 | 2 | 1 | 2 | 10 | 105 | 38 | 67 | 64% | 3-0 | 0.95 | 1.00 |
| 2005-04-26 | Carlos Zambrano | R | 24 | W 9-11 | vs CIN | 5 | 85 | - | 4.2 | 7 | 6 | 6 | 1 | 3 | 5 | 99 | 39 | 60 | 61% | 2-0 | 4.35 | 1.23 |
| 2005-04-27 | Ryan Dempster | R | 28 | L 8-7 | vs CIN | 5 | 161 | - | 5.1 | 8 | 6 | 6 | 1 | 5 | 7 | 97 | 43 | 54 | 56% | 1-3 | 5.67 | 1.78 |
| 2005-04-29 | Greg Maddux | R | 39 | W 3-2 | @ HOU | 5 | 609 | W | 6.0 | 7 | 2 | 2 | 1 | 1 | 3 | 88 | 33 | 55 | 63% | 1-1 | 4.20 | 1.17 |
| 2005-04-30 | Kerry Wood | R | 28 | L 5-7 | @ HOU | 5 | 169 | - | 3.0 | 4 | 3 | 3 | 0 | 2 | 6 | 52 | 20 | 32 | 62% | 1-1 | 6.23 | 1.62 |
| 2005-05-01 | Mark Prior | R | 25 | L 3-9 | @ HOU | 4 | 74 | L | 5.0 | 7 | 8 | 8 | 2 | 3 | 7 | 107 | 29 | 78 | 73% | 3-1 | 3.75 | 1.21 |
| 2005-05-03 | Carlos Zambrano | R | 24 | L 1-4 | @ MIL | 6 | 86 | L | 7.0 | 7 | 3 | 3 | 0 | 4 | 10 | 95 | 34 | 61 | 64% | 2-1 | 4.26 | 1.29 |
| 2005-05-04 | Ryan Dempster | R | 28 | L 3-4 | @ MIL | 6 | 162 | - | 6.2 | 6 | 3 | 3 | 1 | 5 | 6 | 114 | 52 | 62 | 54% | 1-3 | 5.29 | 1.74 |
| 2005-05-05 | Greg Maddux | R | 39 | L 5-6 | @ MIL | 6 | 610 | - | 6.0 | 8 | 4 | 4 | 1 | 3 | 5 | 104 | 43 | 61 | 59% | 1-1 | 4.50 | 1.28 |
| 2005-05-06 | Mark Prior | R | 25 | W 2-3 | vs PHI | 5 | 75 | - | 8.0 | 4 | 1 | 1 | 1 | 2 | 10 | 103 | 37 | 66 | 64% | 3-1 | 3.09 | 1.09 |
| 2005-05-07 | Glendon Rusch | L | 30 | W 1-4 | vs PHI | 1 | 184 | L | 4.2 | 8 | 2 | 2 | 0 | 1 | 3 | 80 | 30 | 50 | 63% | 2-1 | 2.70 | 1.85 |
| 2005-05-08 | Carlos Zambrano | R | 24 | L 2-1 | vs PHI | 7 | 87 | W | 9.0 | 5 | 1 | 1 | 1 | 3 | 5 | 135 | 48 | 87 | 64% | 3-1 | 3.64 | 1.21 |
| 2005-05-09 | Jon Leicester | R | 26 | W 4-7 | vs NYN | 1 | 1 | - | 3.0 | 5 | 4 | 4 | 2 | 1 | 3 | 57 | 22 | 35 | 61% | 0-2 | 9.00 | 2.22 |
| 2005-05-10 | Greg Maddux | R | 39 | L 7-0 | vs NYN | 7 | 611 | W | 6.2 | 3 | 0 | 0 | 0 | 3 | 10 | 99 | 41 | 58 | 59% | 2-1 | 3.77 | 1.21 |
| 2005-05-11 | Mark Prior | R | 25 | L 4-3 | vs NYN | 6 | 76 | - | 7.0 | 2 | 2 | 1 | 0 | 3 | 7 | 106 | 38 | 68 | 64% | 3-1 | 2.77 | 1.03 |
| 2005-05-13 | Glendon Rusch | L | 31 | W 6-3 | @ WAS | 2 | 185 | - | 5.0 | 6 | 2 | 2 | 0 | 2 | 2 | 88 | 35 | 53 | 60% | 2-1 | 2.88 | 1.80 |
| 2005-05-14 | Carlos Zambrano | R | 24 | L 3-4 | @ WAS | 8 | 88 | L | 3.1 | 4 | 4 | 4 | 0 | 0 | 4 | 61 | 21 | 40 | 66% | 3-2 | 4.06 | 1.20 |
| 2005-05-15 | Greg Maddux | R | 39 | L 4-5 | @ WAS | 8 | 612 | - | 5.0 | 7 | 4 | 4 | 1 | 1 | 2 | 69 | 23 | 46 | 67% | 2-1 | 4.13 | 1.25 |
| 2005-05-17 | Mark Prior | R | 25 | W 4-3 | @ PIT | 7 | 77 | - | 7.0 | 7 | 3 | 3 | 2 | 1 | 6 | 100 | 34 | 66 | 66% | 3-1 | 2.93 | 1.04 |
| 2005-05-18 | Glendon Rusch | L | 31 | W 3-2 | @ PIT | 3 | 186 | - | 6.0 | 4 | 2 | 2 | 0 | 6 | 7 | 99 | 40 | 59 | 60% | 2-1 | 2.90 | 1.77 |
| 2005-05-20 | Greg Maddux | R | 39 | W 1-5 | vs CHA | 9 | 613 | L | 7.0 | 9 | 4 | 3 | 1 | 0 | 1 | 95 | 32 | 63 | 66% | 2-2 | 4.09 | 1.25 |
| 2005-05-21 | Carlos Zambrano | R | 24 | W 3-5 | vs CHA | 9 | 89 | - | 7.0 | 1 | 0 | 0 | 0 | 3 | 8 | 108 | 43 | 65 | 60% | 3-2 | 3.57 | 1.12 |
| 2005-05-22 | Mark Prior | R | 25 | L 4-3 | vs CHA | 8 | 78 | W | 9.0 | 6 | 3 | 3 | 3 | 1 | 7 | 123 | 42 | 81 | 66% | 4-1 | 2.95 | 1.00 |
| 2005-05-23 | Glendon Rusch | L | 31 | L 4-1 | vs HOU | 4 | 187 | W | 8.0 | 5 | 1 | 1 | 1 | 1 | 6 | 108 | 39 | 69 | 64% | 3-1 | 2.54 | 1.56 |
| 2005-05-24 | Sergio Mitre | R | 24 | L 4-2 | vs HOU | 1 | 12 | - | 7.0 | 5 | 2 | 2 | 0 | 1 | 5 | 108 | 38 | 70 | 65% | 0-0 | 2.57 | 0.86 |
| 2005-05-25 | Greg Maddux | R | 39 | W 1-5 | vs HOU | 10 | 614 | L | 7.2 | 8 | 5 | 5 | 1 | 0 | 4 | 94 | 31 | 63 | 67% | 2-3 | 4.35 | 1.24 |
| 2005-05-26 | Carlos Zambrano | R | 24 | W 2-5 | vs COL | 10 | 90 | L | 7.0 | 5 | 3 | 3 | 0 | 3 | 5 | 104 | 43 | 61 | 59% | 3-3 | 3.60 | 1.12 |
| 2005-05-27 | Mark Prior | R | 25 | L 10-3 | vs COL | 9 | 79 | - | 3.1 | 2 | 1 | 1 | 0 | 3 | 3 | 54 | 19 | 35 | 65% | 4-1 | 2.95 | 1.03 |
| 2005-05-28 | Glendon Rusch | L | 31 | L 5-1 | vs COL | 5 | 188 | W | 7.0 | 4 | 1 | 1 | 0 | 3 | 4 | 112 | 44 | 68 | 61% | 4-1 | 2.35 | 1.48 |
| 2005-05-29 | Sergio Mitre | R | 24 | L 11-6 | vs COL | 2 | 13 | - | 5.1 | 9 | 6 | 6 | 3 | 1 | 1 | 87 | 33 | 54 | 62% | 0-0 | 6.00 | 1.33 |
| 2005-05-30 | Greg Maddux | R | 39 | W 5-3 | @ LAN | 11 | 615 | W | 6.0 | 5 | 2 | 1 | 0 | 0 | 3 | 84 | 32 | 52 | 62% | 3-3 | 4.10 | 1.21 |
| 2005-05-31 | Carlos Zambrano | R | 24 | W 2-1 | @ LAN | 11 | 91 | - | 8.0 | 1 | 1 | 0 | 0 | 2 | 9 | 121 | 45 | 76 | 63% | 3-3 | 3.21 | 1.04 |
| 2005-06-01 | John Koronka | L | 25 | W 9-5 | @ LAN | 1 | 1 | W | 5.0 | 6 | 3 | 3 | 1 | 3 | 4 | 95 | 34 | 61 | 64% | 1-0 | 5.40 | 1.80 |
| 2005-06-02 | Glendon Rusch | L | 31 | W 5-0 | @ SDN | 6 | 189 | W | 9.0 | 4 | 0 | 0 | 0 | 1 | 7 | 121 | 41 | 80 | 66% | 5-1 | 1.96 | 1.33 |
| 2005-06-03 | Sergio Mitre | R | 24 | L 2-6 | @ SDN | 3 | 14 | L | 4.2 | 6 | 5 | 5 | 0 | 3 | 0 | 78 | 35 | 43 | 55% | 0-1 | 6.88 | 1.47 |
| 2005-06-04 | Greg Maddux | R | 39 | W 11-5 | @ SDN | 12 | 616 | W | 6.0 | 8 | 3 | 3 | 1 | 1 | 4 | 92 | 33 | 59 | 64% | 4-3 | 4.14 | 1.23 |
| 2005-06-05 | Carlos Zambrano | R | 24 | W 4-0 | @ SDN | 12 | 92 | W | 7.0 | 3 | 0 | 0 | 0 | 4 | 7 | 113 | 50 | 63 | 56% | 4-3 | 2.93 | 1.04 |
| 2005-06-06 | John Koronka | L | 25 | W 1-4 | vs TOR | 2 | 2 | L | 6.0 | 6 | 4 | 4 | 1 | 2 | 5 | 103 | 41 | 62 | 60% | 1-1 | 5.73 | 1.55 |
| 2005-06-07 | Glendon Rusch | L | 31 | W 4-6 | vs TOR | 7 | 190 | - | 6.0 | 4 | 3 | 2 | 0 | 3 | 2 | 103 | 43 | 60 | 58% | 5-1 | 2.07 | 1.31 |
| 2005-06-08 | Sergio Mitre | R | 24 | L 2-0 | vs TOR | 4 | 15 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 6 | 104 | 46 | 58 | 56% | 1-1 | 4.88 | 1.17 |
| 2005-06-10 | Greg Maddux | R | 39 | L 14-6 | vs BOS | 13 | 617 | W | 6.2 | 7 | 3 | 3 | 1 | 1 | 5 | 86 | 25 | 61 | 71% | 5-3 | 4.11 | 1.22 |
| 2005-06-11 | Carlos Zambrano | R | 24 | L 7-6 | vs BOS | 13 | 93 | - | 5.0 | 5 | 4 | 4 | 2 | 3 | 8 | 98 | 37 | 61 | 62% | 4-3 | 3.18 | 1.07 |
| 2005-06-12 | Glendon Rusch | L | 31 | W 1-8 | vs BOS | 8 | 191 | L | 5.2 | 11 | 5 | 5 | 2 | 1 | 7 | 114 | 35 | 79 | 69% | 5-2 | 2.55 | 1.37 |
| 2005-06-13 | John Koronka | L | 25 | W 1-9 | vs FLO | 3 | 3 | L | 4.1 | 7 | 6 | 6 | 0 | 3 | 1 | 83 | 34 | 49 | 59% | 1-2 | 7.80 | 1.80 |
| 2005-06-14 | Sergio Mitre | R | 24 | L 14-0 | vs FLO | 5 | 16 | W | 9.0 | 5 | 0 | 0 | 0 | 0 | 3 | 96 | 26 | 70 | 73% | 2-1 | 3.55 | 1.00 |
| 2005-06-15 | Greg Maddux | R | 39 | W 5-15 | vs FLO | 14 | 618 | L | 3.2 | 8 | 7 | 7 | 1 | 2 | 3 | 68 | 26 | 42 | 62% | 5-4 | 4.66 | 1.28 |
| 2005-06-17 | Carlos Zambrano | R | 24 | L 6-9 | @ NYA | 14 | 94 | - | 6.1 | 9 | 6 | 6 | 0 | 6 | 3 | 116 | 49 | 67 | 58% | 4-3 | 3.56 | 1.16 |
| 2005-06-18 | Glendon Rusch | L | 31 | L 1-8 | @ NYA | 9 | 192 | L | 5.0 | 9 | 5 | 4 | 0 | 1 | 3 | 98 | 36 | 62 | 63% | 5-3 | 2.88 | 1.42 |
| 2005-06-19 | Sergio Mitre | R | 24 | L 3-6 | @ NYA | 6 | 17 | L | 5.2 | 8 | 6 | 5 | 0 | 4 | 2 | 114 | 49 | 65 | 57% | 2-2 | 4.15 | 1.15 |
| 2005-06-20 | Greg Maddux | R | 39 | W 5-4 | @ MIL | 15 | 619 | W | 6.0 | 7 | 3 | 3 | 1 | 3 | 2 | 99 | 40 | 59 | 60% | 6-4 | 4.65 | 1.31 |
| 2005-06-21 | Jerome Williams | R | 24 | W 4-2 | @ MIL | 4 | 47 | W | 7.0 | 3 | 2 | 2 | 2 | 4 | 6 | 101 | 41 | 60 | 59% | 1-2 | 5.25 | 1.33 |
| 2005-06-22 | Carlos Zambrano | R | 24 | L 4-9 | @ MIL | 15 | 95 | L | 1.2 | 7 | 8 | 8 | 1 | 1 | 2 | 51 | 17 | 34 | 67% | 4-4 | 4.26 | 1.23 |
| 2005-06-23 | Glendon Rusch | L | 31 | L 7-8 | @ MIL | 10 | 193 | - | 6.0 | 7 | 4 | 4 | 2 | 3 | 2 | 102 | 41 | 61 | 60% | 5-3 | 3.12 | 1.44 |
| 2005-06-24 | Sergio Mitre | R | 24 | L 2-12 | @ CHA | 7 | 18 | L | 4.2 | 7 | 7 | 7 | 1 | 4 | 2 | 106 | 45 | 61 | 58% | 2-3 | 5.23 | 1.30 |
| 2005-06-25 | Greg Maddux | R | 39 | W 6-2 | @ CHA | 16 | 620 | W | 6.0 | 5 | 2 | 2 | 2 | 0 | 6 | 95 | 30 | 65 | 68% | 7-4 | 4.55 | 1.28 |
| 2005-06-26 | Mark Prior | R | 25 | W 2-0 | @ CHA | 10 | 80 | W | 6.0 | 1 | 0 | 0 | 0 | 0 | 3 | 70 | 21 | 49 | 70% | 5-1 | 2.67 | 0.95 |
| 2005-06-28 | Carlos Zambrano | R | 24 | L 2-0 | vs MIL | 16 | 96 | W | 8.0 | 3 | 0 | 0 | 0 | 3 | 6 | 115 | 39 | 76 | 66% | 5-4 | 3.92 | 1.19 |
| 2005-06-29 | Kerry Wood | R | 28 | L 3-2 | vs MIL | 6 | 170 | - | 6.0 | 2 | 1 | 1 | 1 | 2 | 9 | 91 | 26 | 65 | 71% | 1-1 | 5.34 | 1.44 |
| 2005-06-30 | Greg Maddux | R | 39 | W 6-10 | vs MIL | 17 | 621 | L | 5.0 | 10 | 6 | 6 | 1 | 1 | 2 | 88 | 29 | 59 | 67% | 7-5 | 4.85 | 1.32 |
| 2005-07-01 | Mark Prior | R | 25 | W 3-4 | vs WAS | 11 | 81 | L | 5.0 | 6 | 3 | 3 | 1 | 0 | 7 | 81 | 22 | 59 | 73% | 5-2 | 2.87 | 0.97 |
| 2005-07-02 | Jerome Williams | R | 24 | W 2-4 | vs WAS | 5 | 48 | L | 7.0 | 5 | 4 | 4 | 1 | 1 | 3 | 88 | 28 | 60 | 68% | 1-3 | 4.91 | 1.18 |
| 2005-07-03 | Carlos Zambrano | R | 24 | W 4-5 | vs WAS | 17 | 97 | - | 7.0 | 6 | 2 | 2 | 0 | 3 | 7 | 120 | 47 | 73 | 61% | 5-4 | 3.83 | 1.19 |
| 2005-07-04 | Kerry Wood | R | 28 | L 0-4 | @ ATL | 7 | 171 | L | 5.0 | 6 | 3 | 3 | 1 | 3 | 6 | 102 | 37 | 65 | 64% | 1-2 | 5.35 | 1.49 |
| 2005-07-05 | Greg Maddux | R | 39 | L 1-5 | @ ATL | 18 | 622 | L | 6.0 | 8 | 5 | 5 | 0 | 1 | 6 | 88 | 30 | 58 | 66% | 7-6 | 5.00 | 1.33 |
| 2005-07-07 | Mark Prior | R | 25 | L 0-6 | @ ATL | 12 | 82 | L | 4.2 | 7 | 6 | 6 | 1 | 4 | 5 | 101 | 39 | 62 | 61% | 5-3 | 3.41 | 1.05 |
| 2005-07-07 | Jerome Williams | R | 24 | L 4-9 | @ ATL | 6 | 49 | - | 6.0 | 8 | 3 | 3 | 1 | 2 | 3 | 105 | 42 | 63 | 60% | 1-3 | 4.85 | 1.26 |
| 2005-07-08 | Carlos Zambrano | R | 24 | W 9-6 | @ FLO | 18 | 98 | W | 7.0 | 6 | 3 | 3 | 1 | 6 | 7 | 123 | 60 | 63 | 51% | 6-4 | 3.83 | 1.23 |
| 2005-07-09 | Kerry Wood | R | 28 | W 8-2 | @ FLO | 8 | 172 | W | 7.2 | 6 | 2 | 2 | 1 | 1 | 4 | 105 | 36 | 69 | 66% | 2-2 | 4.80 | 1.38 |
| 2005-07-10 | Greg Maddux | R | 39 | W 9-2 | @ FLO | 19 | 623 | W | 8.0 | 4 | 0 | 0 | 0 | 0 | 3 | 102 | 34 | 68 | 67% | 8-6 | 4.66 | 1.28 |
| 2005-07-14 | Mark Prior | R | 25 | L 5-1 | vs PIT | 13 | 83 | W | 8.0 | 2 | 1 | 0 | 0 | 3 | 10 | 114 | 37 | 77 | 68% | 6-3 | 3.07 | 1.01 |
| 2005-07-15 | Kerry Wood | R | 28 | L 11-1 | vs PIT | 9 | 173 | W | 6.0 | 2 | 1 | 1 | 1 | 0 | 5 | 75 | 27 | 48 | 64% | 3-2 | 4.41 | 1.25 |
| 2005-07-16 | Greg Maddux | R | 39 | W 0-3 | vs PIT | 20 | 624 | L | 8.0 | 5 | 3 | 2 | 1 | 1 | 6 | 101 | 27 | 74 | 73% | 8-7 | 4.50 | 1.24 |
| 2005-07-17 | Carlos Zambrano | R | 24 | L 8-2 | vs PIT | 19 | 99 | W | 8.0 | 5 | 1 | 0 | 0 | 4 | 4 | 95 | 33 | 62 | 65% | 7-4 | 3.59 | 1.22 |
| 2005-07-18 | Jerome Williams | R | 24 | W 9-4 | @ CIN | 7 | 50 | W | 6.2 | 6 | 4 | 4 | 1 | 1 | 3 | 110 | 45 | 65 | 59% | 2-3 | 5.00 | 1.24 |
| 2005-07-19 | Mark Prior | R | 25 | W 7-3 | @ CIN | 14 | 84 | W | 6.2 | 7 | 3 | 3 | 0 | 2 | 8 | 108 | 42 | 66 | 61% | 7-3 | 3.13 | 1.03 |
| 2005-07-20 | Kerry Wood | R | 28 | L 3-9 | @ CIN | 10 | 174 | L | 3.0 | 4 | 3 | 3 | 3 | 1 | 3 | 65 | 25 | 40 | 62% | 3-3 | 4.67 | 1.28 |
| 2005-07-21 | Greg Maddux | R | 39 | L 6-9 | @ CIN | 21 | 625 | - | 5.0 | 9 | 3 | 3 | 2 | 0 | 4 | 75 | 22 | 53 | 71% | 8-7 | 4.53 | 1.26 |
| 2005-07-22 | Carlos Zambrano | R | 24 | L 1-2 | @ SLN | 20 | 100 | - | 9.0 | 3 | 1 | 1 | 1 | 0 | 12 | 117 | 40 | 77 | 66% | 7-4 | 3.41 | 1.16 |
| 2005-07-23 | Jerome Williams | R | 24 | W 6-5 | @ SLN | 8 | 51 | W | 6.0 | 7 | 4 | 3 | 0 | 3 | 3 | 106 | 40 | 66 | 62% | 3-3 | 4.94 | 1.29 |
| 2005-07-24 | Mark Prior | R | 25 | W 8-4 | @ SLN | 15 | 85 | - | 6.0 | 5 | 3 | 3 | 3 | 3 | 2 | 108 | 39 | 69 | 64% | 7-3 | 3.22 | 1.05 |
| 2005-07-25 | Rich Hill | L | 25 | L 3-2 | vs SFN | 1 | 1 | - | 5.0 | 5 | 2 | 2 | 1 | 2 | 5 | 98 | 37 | 61 | 62% | 0-0 | 4.09 | 1.18 |
| 2005-07-26 | Greg Maddux | R | 39 | W 2-3 | vs SFN | 22 | 626 | - | 8.0 | 8 | 2 | 2 | 0 | 2 | 3 | 89 | 30 | 59 | 66% | 8-7 | 4.40 | 1.26 |
| 2005-07-27 | Carlos Zambrano | R | 24 | L 4-3 | vs SFN | 21 | 101 | - | 7.1 | 11 | 3 | 3 | 0 | 4 | 4 | 118 | 46 | 72 | 61% | 7-4 | 3.43 | 1.21 |
| 2005-07-28 | Jerome Williams | R | 24 | W 0-6 | vs ARI | 9 | 52 | L | 5.1 | 7 | 1 | 1 | 1 | 4 | 5 | 121 | 51 | 70 | 58% | 3-4 | 4.58 | 1.35 |
| 2005-07-29 | Mark Prior | R | 25 | L 4-3 | vs ARI | 16 | 86 | - | 7.1 | 7 | 3 | 3 | 0 | 2 | 8 | 119 | 41 | 78 | 66% | 7-3 | 3.26 | 1.07 |
| 2005-07-30 | Rich Hill | L | 25 | W 2-3 | vs ARI | 2 | 2 | - | 6.0 | 5 | 2 | 2 | 1 | 2 | 4 | 104 | 39 | 65 | 63% | 0-0 | 3.71 | 1.18 |
| 2005-07-31 | Greg Maddux | R | 39 | W 6-13 | vs ARI | 23 | 627 | L | 4.0 | 8 | 6 | 6 | 1 | 1 | 1 | 68 | 24 | 44 | 65% | 8-8 | 4.66 | 1.29 |
| 2005-08-02 | Carlos Zambrano | R | 24 | W 2-1 | @ PHI | 22 | 102 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 4 | 104 | 36 | 68 | 65% | 8-4 | 3.24 | 1.18 |
| 2005-08-03 | Jerome Williams | R | 24 | L 3-4 | @ PHI | 10 | 53 | - | 4.0 | 5 | 3 | 2 | 0 | 1 | 1 | 69 | 23 | 46 | 67% | 3-4 | 4.57 | 1.36 |
| 2005-08-04 | Mark Prior | R | 25 | L 4-6 | @ PHI | 17 | 87 | L | 4.1 | 6 | 6 | 6 | 3 | 3 | 7 | 99 | 34 | 65 | 66% | 7-4 | 3.65 | 1.11 |
| 2005-08-05 | Rich Hill | L | 25 | L 5-9 | @ NYN | 3 | 3 | L | 1.1 | 7 | 7 | 7 | 0 | 2 | 1 | 53 | 22 | 31 | 58% | 0-1 | 7.00 | 1.61 |
| 2005-08-06 | Greg Maddux | R | 39 | L 0-2 | @ NYN | 24 | 628 | L | 7.0 | 4 | 2 | 2 | 0 | 2 | 5 | 112 | 43 | 69 | 62% | 8-9 | 4.56 | 1.27 |
| 2005-08-07 | Carlos Zambrano | R | 24 | L 1-6 | @ NYN | 23 | 103 | L | 3.0 | 4 | 4 | 2 | 0 | 3 | 2 | 81 | 31 | 50 | 62% | 8-5 | 3.30 | 1.20 |
| 2005-08-08 | Jerome Williams | R | 24 | W 4-9 | vs CIN | 11 | 54 | L | 5.1 | 7 | 7 | 7 | 2 | 3 | 2 | 84 | 32 | 52 | 62% | 3-5 | 5.18 | 1.41 |
| 2005-08-09 | Mark Prior | R | 25 | W 3-8 | vs CIN | 18 | 88 | - | 7.0 | 8 | 3 | 3 | 2 | 0 | 11 | 117 | 41 | 76 | 65% | 7-4 | 3.66 | 1.12 |
| 2005-08-10 | Rich Hill | L | 25 | W 2-8 | vs CIN | 4 | 4 | L | 3.0 | 4 | 6 | 6 | 1 | 4 | 2 | 71 | 28 | 43 | 61% | 0-2 | 8.57 | 1.76 |
| 2005-08-11 | Greg Maddux | R | 39 | L 11-4 | vs SLN | 25 | 629 | W | 9.0 | 12 | 4 | 4 | 1 | 0 | 5 | 112 | 27 | 85 | 76% | 9-9 | 4.53 | 1.27 |
| 2005-08-12 | Carlos Zambrano | R | 24 | L 4-1 | vs SLN | 24 | 104 | W | 6.0 | 6 | 0 | 0 | 0 | 1 | 5 | 96 | 32 | 64 | 67% | 9-5 | 3.17 | 1.20 |
| 2005-08-13 | Jerome Williams | R | 24 | W 2-5 | vs SLN | 12 | 55 | L | 6.0 | 4 | 3 | 3 | 1 | 4 | 7 | 112 | 45 | 67 | 60% | 3-6 | 5.13 | 1.40 |
| 2005-08-14 | Mark Prior | R | 25 | L 5-4 | vs SLN | 19 | 89 | W | 6.0 | 7 | 3 | 3 | 1 | 4 | 7 | 123 | 51 | 72 | 59% | 8-4 | 3.71 | 1.15 |
| 2005-08-15 | Glendon Rusch | L | 31 | L 4-12 | @ HOU | 11 | 194 | L | 3.2 | 10 | 5 | 5 | 1 | 2 | 4 | 92 | 31 | 61 | 66% | 5-5 | 4.28 | 1.59 |
| 2005-08-16 | Greg Maddux | R | 39 | W 4-1 | @ HOU | 26 | 630 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 5 | 74 | 25 | 49 | 66% | 10-9 | 4.39 | 1.25 |
| 2005-08-17 | Carlos Zambrano | R | 24 | W 4-2 | @ HOU | 25 | 105 | W | 8.1 | 3 | 2 | 1 | 0 | 3 | 10 | 116 | 44 | 72 | 62% | 10-5 | 3.07 | 1.18 |
| 2005-08-19 | Mark Prior | R | 25 | W 5-3 | @ COL | 20 | 90 | W | 6.0 | 5 | 2 | 2 | 1 | 2 | 10 | 116 | 41 | 75 | 65% | 9-4 | 3.67 | 1.15 |
| 2005-08-20 | Glendon Rusch | L | 31 | L 2-4 | @ COL | 12 | 195 | L | 6.0 | 7 | 3 | 2 | 0 | 1 | 6 | 94 | 29 | 65 | 69% | 5-6 | 4.21 | 1.58 |
| 2005-08-21 | Greg Maddux | R | 39 | L 7-9 | @ COL | 27 | 631 | L | 6.0 | 8 | 6 | 6 | 3 | 1 | 3 | 87 | 27 | 60 | 69% | 10-10 | 4.55 | 1.26 |
| 2005-08-22 | Carlos Zambrano | R | 24 | W 2-4 | vs ATL | 26 | 106 | - | 8.0 | 3 | 2 | 2 | 1 | 0 | 10 | 117 | 42 | 75 | 64% | 10-5 | 3.03 | 1.14 |
| 2005-08-23 | Jerome Williams | R | 24 | L 10-1 | vs ATL | 13 | 56 | W | 7.2 | 3 | 1 | 1 | 1 | 3 | 5 | 112 | 44 | 68 | 61% | 4-6 | 4.73 | 1.34 |
| 2005-08-24 | Mark Prior | R | 25 | W 1-3 | vs ATL | 21 | 91 | L | 6.2 | 4 | 3 | 3 | 0 | 4 | 7 | 131 | 49 | 82 | 63% | 9-5 | 3.68 | 1.15 |
| 2005-08-26 | Glendon Rusch | L | 31 | W 5-7 | vs FLO | 13 | 196 | L | 4.2 | 8 | 5 | 4 | 0 | 2 | 2 | 89 | 35 | 54 | 61% | 5-7 | 4.34 | 1.60 |
| 2005-08-27 | Greg Maddux | R | 39 | W 1-2 | vs FLO | 28 | 632 | L | 9.0 | 5 | 2 | 2 | 0 | 1 | 2 | 102 | 34 | 68 | 67% | 10-11 | 4.42 | 1.23 |
| 2005-08-28 | Carlos Zambrano | R | 24 | L 14-3 | vs FLO | 27 | 107 | W | 8.0 | 6 | 3 | 3 | 1 | 2 | 6 | 108 | 40 | 68 | 63% | 11-5 | 3.05 | 1.13 |
| 2005-08-29 | Jerome Williams | R | 24 | W 6-9 | vs LAN | 14 | 57 | L | 1.2 | 5 | 6 | 5 | 0 | 3 | 0 | 45 | 24 | 21 | 47% | 4-7 | 5.22 | 1.42 |
| 2005-08-30 | Mark Prior | R | 25 | L 6-3 | vs LAN | 22 | 92 | W | 6.0 | 8 | 3 | 3 | 2 | 0 | 7 | 94 | 31 | 63 | 67% | 10-5 | 3.72 | 1.16 |
| 2005-08-31 | Glendon Rusch | L | 31 | W 0-7 | vs LAN | 14 | 197 | L | 2.0 | 7 | 7 | 7 | 1 | 2 | 3 | 55 | 18 | 37 | 67% | 5-8 | 4.82 | 1.65 |
| 2005-09-02 | Greg Maddux | R | 39 | W 7-3 | @ PIT | 29 | 633 | W | 5.0 | 5 | 2 | 2 | 0 | 0 | 6 | 79 | 27 | 52 | 66% | 11-11 | 4.40 | 1.22 |
| 2005-09-03 | Carlos Zambrano | R | 24 | W 9-5 | @ PIT | 28 | 108 | W | 7.2 | 5 | 5 | 5 | 0 | 4 | 9 | 119 | 45 | 74 | 62% | 12-5 | 3.16 | 1.13 |
| 2005-09-04 | Jerome Williams | R | 24 | W 2-0 | @ PIT | 15 | 58 | W | 7.1 | 4 | 0 | 0 | 0 | 2 | 5 | 95 | 38 | 57 | 60% | 5-7 | 4.75 | 1.36 |
| 2005-09-05 | Mark Prior | R | 25 | L 4-6 | @ SLN | 23 | 93 | - | 6.0 | 5 | 2 | 2 | 0 | 2 | 6 | 104 | 38 | 66 | 63% | 10-5 | 3.69 | 1.16 |
| 2005-09-06 | Glendon Rusch | L | 31 | W 5-2 | @ SLN | 15 | 198 | W | 7.2 | 4 | 2 | 2 | 0 | 1 | 3 | 109 | 31 | 78 | 72% | 6-8 | 4.69 | 1.60 |
| 2005-09-07 | Greg Maddux | R | 39 | W 2-1 | @ SLN | 30 | 634 | W | 5.2 | 7 | 0 | 0 | 0 | 2 | 4 | 96 | 35 | 61 | 64% | 12-11 | 4.29 | 1.24 |
| 2005-09-08 | Carlos Zambrano | R | 24 | W 5-3 | @ SFN | 29 | 109 | W | 7.0 | 6 | 3 | 3 | 1 | 3 | 6 | 122 | 41 | 81 | 66% | 13-5 | 3.18 | 1.14 |
| 2005-09-09 | Jerome Williams | R | 24 | L 1-2 | @ SFN | 16 | 59 | L | 7.0 | 7 | 2 | 1 | 0 | 2 | 1 | 108 | 45 | 63 | 58% | 5-8 | 4.50 | 1.35 |
| 2005-09-10 | Mark Prior | R | 25 | W 5-2 | @ SFN | 24 | 94 | W | 6.2 | 5 | 2 | 2 | 0 | 3 | 7 | 127 | 50 | 77 | 61% | 11-5 | 3.64 | 1.16 |
| 2005-09-11 | Glendon Rusch | L | 31 | W 3-2 | @ SFN | 16 | 199 | - | 5.1 | 7 | 2 | 2 | 0 | 1 | 4 | 98 | 34 | 64 | 65% | 6-8 | 4.61 | 1.58 |
| 2005-09-12 | Greg Maddux | R | 39 | W 2-5 | vs CIN | 31 | 635 | L | 7.0 | 5 | 2 | 2 | 2 | 1 | 5 | 82 | 24 | 58 | 71% | 12-12 | 4.22 | 1.22 |
| 2005-09-13 | Carlos Zambrano | R | 24 | L 4-3 | vs CIN | 30 | 110 | - | 6.0 | 3 | 3 | 3 | 2 | 3 | 9 | 115 | 47 | 68 | 59% | 13-5 | 3.22 | 1.13 |
| 2005-09-14 | Jerome Williams | R | 24 | W 4-7 | vs CIN | 17 | 60 | - | 7.0 | 8 | 1 | 1 | 0 | 1 | 3 | 108 | 39 | 69 | 64% | 5-8 | 4.28 | 1.35 |
| 2005-09-15 | Mark Prior | R | 25 | W 1-6 | vs SLN | 25 | 95 | L | 5.0 | 6 | 3 | 3 | 0 | 1 | 4 | 93 | 31 | 62 | 67% | 11-6 | 3.69 | 1.17 |
| 2005-09-16 | Glendon Rusch | L | 31 | L 5-3 | vs SLN | 17 | 200 | W | 6.2 | 7 | 3 | 3 | 1 | 2 | 4 | 106 | 34 | 72 | 68% | 7-8 | 4.60 | 1.58 |
| 2005-09-17 | Greg Maddux | R | 39 | W 1-5 | vs SLN | 32 | 636 | L | 6.1 | 10 | 5 | 5 | 0 | 1 | 3 | 102 | 36 | 66 | 65% | 12-13 | 4.30 | 1.24 |
| 2005-09-18 | Carlos Zambrano | R | 24 | L 7-4 | vs SLN | 31 | 111 | W | 9.0 | 10 | 4 | 2 | 1 | 1 | 1 | 124 | 43 | 81 | 65% | 14-5 | 3.17 | 1.14 |
| 2005-09-20 | Jerome Williams | R | 24 | L 3-5 | @ MIL | 18 | 61 | L | 6.0 | 9 | 4 | 4 | 1 | 2 | 4 | 102 | 38 | 64 | 63% | 5-9 | 4.38 | 1.38 |
| 2005-09-21 | Mark Prior | R | 25 | L 6-7 | @ MIL | 26 | 96 | - | 6.0 | 6 | 3 | 3 | 1 | 4 | 10 | 120 | 48 | 72 | 60% | 11-6 | 3.72 | 1.19 |
| 2005-09-22 | Greg Maddux | R | 39 | W 3-0 | @ MIL | 33 | 637 | W | 8.0 | 4 | 0 | 0 | 0 | 0 | 4 | 78 | 23 | 55 | 71% | 13-13 | 4.14 | 1.21 |
| 2005-09-23 | Glendon Rusch | L | 31 | L 5-4 | vs HOU | 18 | 201 | W | 5.0 | 9 | 4 | 3 | 1 | 1 | 3 | 105 | 36 | 69 | 66% | 8-8 | 4.63 | 1.59 |
| 2005-09-24 | Carlos Zambrano | R | 24 | W 3-8 | vs HOU | 32 | 112 | L | 6.1 | 9 | 6 | 6 | 2 | 1 | 4 | 94 | 33 | 61 | 65% | 14-6 | 3.33 | 1.15 |
| 2005-09-25 | Jerome Williams | R | 24 | L 3-2 | vs HOU | 19 | 62 | W | 7.0 | 4 | 2 | 2 | 0 | 6 | 3 | 108 | 53 | 55 | 51% | 6-9 | 4.27 | 1.38 |
| 2005-09-27 | Greg Maddux | R | 39 | W 3-5 | vs PIT | 34 | 638 | L | 9.0 | 8 | 5 | 5 | 2 | 1 | 6 | 114 | 35 | 79 | 69% | 13-14 | 4.17 | 1.20 |
| 2005-09-28 | Mark Prior | R | 25 | W 2-3 | vs PIT | 27 | 97 | L | 5.0 | 6 | 3 | 1 | 1 | 4 | 7 | 96 | 35 | 61 | 64% | 11-7 | 3.66 | 1.21 |
| 2005-09-29 | Glendon Rusch | L | 31 | W 3-2 | @ HOU | 19 | 202 | W | 7.0 | 7 | 2 | 2 | 1 | 1 | 5 | 94 | 34 | 60 | 64% | 9-8 | 4.53 | 1.57 |
| 2005-09-30 | Carlos Zambrano | R | 24 | W 4-3 | @ HOU | 33 | 113 | - | 7.0 | 4 | 1 | 1 | 1 | 3 | 8 | 113 | 44 | 69 | 61% | 14-6 | 3.27 | 1.15 |
| 2005-10-01 | Jerome Williams | R | 24 | L 1-3 | @ HOU | 20 | 63 | L | 7.0 | 6 | 3 | 3 | 1 | 2 | 3 | 91 | 33 | 58 | 64% | 6-10 | 4.24 | 1.37 |
| 2005-10-02 | Greg Maddux | R | 39 | L 4-6 | @ HOU | 35 | 639 | L | 5.1 | 10 | 6 | 4 | 1 | 1 | 2 | 96 | 35 | 61 | 64% | 13-15 | 4.24 | 1.22 |