| 2005-04-04 | vs WAS | 1 | W 8-4 | 1-0 | 1 | 44,080 | Jon Lieber | Livan Hernandez | Jon Lieber | Livan Hernandez | | 8 | 4 | 4 |
| 2005-04-06 | vs WAS | 2 | L 3-7 | 1-1 | 3 | 23,435 | Brett Myers | Zach Day | Joey Eischen | Tim Worrell | | 11 | 11 | 0 |
| 2005-04-07 | vs WAS | 3 | L 4-5 | 1-2 | 4 | 21,693 | Randy Wolf | Esteban Loaiza | Chad Cordero | Rheal Cormier | | 15 | 16 | -1 |
| 2005-04-08 | @ SLN | 4 | L 5-6 | 1-3 | 4 | 50,074 | Cory Lidle | Mark Mulder | Alberto Reyes | Ryan Madson | Jason Isringhausen | 20 | 22 | -2 |
| 2005-04-09 | @ SLN | 5 | W 10-4 | 2-3 | 4 | 39,242 | Gavin Floyd | Jeff Suppan | Gavin Floyd | Jeff Suppan | | 30 | 26 | 4 |
| 2005-04-10 | @ SLN | 6 | W 13-4 | 3-3 | 3 | 37,971 | Jon Lieber | Chris Carpenter | Jon Lieber | Chris Carpenter | | 43 | 30 | 13 |
| 2005-04-11 | @ FLO | 7 | W 4-1 | 4-3 | 2 | 11,416 | Brett Myers | Al Leiter | Brett Myers | Al Leiter | Billy Wagner | 47 | 31 | 16 |
| 2005-04-12 | @ FLO | 8 | L 2-8 | 4-4 | 3 | 15,129 | Randy Wolf | A.J. Burnett | A.J. Burnett | Randy Wolf | | 49 | 39 | 10 |
| 2005-04-13 | @ FLO | 9 | L 0-4 | 4-5 | 4 | 14,427 | Cory Lidle | Dontrelle Willis | Dontrelle Willis | Cory Lidle | | 49 | 43 | 6 |
| 2005-04-15 | vs ATL | 10 | L 4-11 | 4-6 | 5 | 31,408 | Gavin Floyd | Horacio Ramirez | Horacio Ramirez | Gavin Floyd | | 53 | 54 | -1 |
| 2005-04-16 | vs ATL | 11 | W 2-1 | 5-6 | 5 | 36,820 | Jon Lieber | John Smoltz | Jon Lieber | John Smoltz | Billy Wagner | 55 | 55 | 0 |
| 2005-04-17 | vs ATL | 12 | W 2-1 | 6-6 | 5 | 32,008 | Brett Myers | Mike Hampton | Ryan Madson | Danny Kolb | | 57 | 56 | 1 |
| 2005-04-18 | vs NYN | 13 | W 5-4 | 7-6 | 4 | 25,236 | Randy Wolf | Kazuhisa Ishii | Randy Wolf | Kazuhisa Ishii | Tim Worrell | 62 | 60 | 2 |
| 2005-04-19 | vs NYN | 14 | L 4-16 | 7-7 | 5 | 28,063 | Vicente Padilla | Victor Zambrano | Victor Zambrano | Vicente Padilla | | 66 | 76 | -10 |
| 2005-04-20 | vs COL | 15 | L 4-7 | 7-8 | 5 | 25,961 | Cory Lidle | Jamey Wright | Jamey Wright | Cory Lidle | | 70 | 83 | -13 |
| 2005-04-21 | vs COL | 16 | W 6-3 | 8-8 | 5 | 21,749 | Jon Lieber | Joe Kennedy | Jon Lieber | Joe Kennedy | Billy Wagner | 76 | 86 | -10 |
| 2005-04-22 | @ ATL | 17 | L 2-6 | 8-9 | 5 | 26,837 | Brett Myers | Mike Hampton | Mike Hampton | Brett Myers | Danny Kolb | 78 | 92 | -14 |
| 2005-04-23 | @ ATL | 18 | L 1-11 | 8-10 | 5 | 31,656 | Randy Wolf | Tim Hudson | Tim Hudson | Randy Wolf | | 79 | 103 | -24 |
| 2005-04-24 | @ ATL | 19 | L 0-4 | 8-11 | 5 | 26,713 | Vicente Padilla | John Thomson | John Thomson | Vicente Padilla | | 79 | 107 | -28 |
| 2005-04-25 | @ WAS | 20 | W 5-4 | 9-11 | 5 | 24,956 | Cory Lidle | Zach Day | Cory Lidle | Zach Day | Billy Wagner | 84 | 111 | -27 |
| 2005-04-26 | @ WAS | 21 | L 1-3 | 9-12 | 5 | 23,332 | Jon Lieber | John Patterson | John Patterson | Jon Lieber | Chad Cordero | 85 | 114 | -29 |
| 2005-04-27 | @ WAS | 22 | W 3-0 | 10-12 | 5 | 27,483 | Brett Myers | Esteban Loaiza | Rheal Cormier | Esteban Loaiza | Billy Wagner | 88 | 114 | -26 |
| 2005-04-29 | vs FLO | 23 | L 4-6 | 10-13 | 5 | 28,471 | Randy Wolf | A.J. Burnett | A.J. Burnett | Randy Wolf | Todd Jones | 92 | 120 | -28 |
| 2005-04-30 | vs FLO | 24 | L 1-2 | 10-14 | 5 | 25,900 | Vicente Padilla | Dontrelle Willis | Dontrelle Willis | Vicente Padilla | | 93 | 122 | -29 |
| 2005-05-01 | vs FLO | 25 | W 8-6 | 11-14 | 5 | 37,306 | Cory Lidle | Josh Beckett | Cory Lidle | Josh Beckett | Billy Wagner | 101 | 128 | -27 |
| 2005-05-02 | @ NYN | 26 | L 1-5 | 11-15 | 5 | 16,897 | Jon Lieber | Pedro Martinez | Pedro Martinez | Terry Adams | | 102 | 133 | -31 |
| 2005-05-03 | @ NYN | 27 | W 10-3 | 12-15 | 5 | 17,051 | Brett Myers | Tom Glavine | Brett Myers | Tom Glavine | | 112 | 136 | -24 |
| 2005-05-04 | @ NYN | 28 | L 2-3 | 12-16 | 5 | 21,356 | Randy Wolf | Jae Weong Seo | Jae Weong Seo | Randy Wolf | Braden Looper | 114 | 139 | -25 |
| 2005-05-05 | @ NYN | 29 | L 5-7 | 12-17 | 5 | 19,553 | Vicente Padilla | Kris Benson | Aaron Heilman | Vicente Padilla | Braden Looper | 119 | 146 | -27 |
| 2005-05-06 | @ CHN | 30 | W 3-2 | 13-17 | 5 | 38,767 | Cory Lidle | Mark Prior | Billy Wagner | LaTroy Hawkins | | 122 | 148 | -26 |
| 2005-05-07 | @ CHN | 31 | W 4-1 | 14-17 | 5 | 38,933 | Jon Lieber | Glendon Rusch | Jon Lieber | Glendon Rusch | Billy Wagner | 126 | 149 | -23 |
| 2005-05-08 | @ CHN | 32 | L 1-2 | 14-18 | 5 | 38,656 | Brett Myers | Carlos Zambrano | Carlos Zambrano | Brett Myers | | 127 | 151 | -24 |
| 2005-05-09 | @ MIL | 33 | W 4-2 | 15-18 | 5 | 11,103 | Randy Wolf | Victor Santos | Randy Wolf | Victor Santos | Billy Wagner | 131 | 153 | -22 |
| 2005-05-10 | @ MIL | 34 | L 5-8 | 15-19 | 5 | 12,082 | Vicente Padilla | Gary Glover | Julio Santana | Terry Adams | Ricky Bottalico | 136 | 161 | -25 |
| 2005-05-11 | @ MIL | 35 | L 2-5 | 15-20 | 5 | 13,175 | Cory Lidle | Doug Davis | Doug Davis | Cory Lidle | Derrick Turnbow | 138 | 166 | -28 |
| 2005-05-12 | vs CIN | 36 | L 5-7 | 15-21 | 5 | 33,663 | Jon Lieber | Ramon Ortiz | Ramon Ortiz | Jon Lieber | Danny Graves | 143 | 173 | -30 |
| 2005-05-13 | vs CIN | 37 | W 12-2 | 16-21 | 5 | 27,071 | Brett Myers | Eric Milton | Brett Myers | Eric Milton | | 155 | 175 | -20 |
| 2005-05-14 | vs CIN | 38 | L 4-12 | 16-22 | 5 | 30,189 | Randy Wolf | Aaron Harang | Aaron Harang | Ryan Madson | | 159 | 187 | -28 |
| 2005-05-15 | vs CIN | 39 | W 4-3 | 17-22 | 5 | 41,141 | Vicente Padilla | Elizardo Ramirez | Vicente Padilla | Elizardo Ramirez | Billy Wagner | 163 | 190 | -27 |
| 2005-05-17 | vs SLN | 40 | W 7-5 | 18-22 | 5 | 32,103 | Cory Lidle | Jeff Suppan | Cory Lidle | Jeff Suppan | Billy Wagner | 170 | 195 | -25 |
| 2005-05-18 | vs SLN | 41 | L 4-8 | 18-23 | 5 | 29,130 | Jon Lieber | Chris Carpenter | Chris Carpenter | Jon Lieber | | 174 | 203 | -29 |
| 2005-05-19 | vs SLN | 42 | W 7-4 | 19-23 | 5 | 38,229 | Brett Myers | Jason Marquis | Brett Myers | Jason Marquis | | 181 | 207 | -26 |
| 2005-05-20 | @ BAL | 43 | W 9-3 | 20-23 | 5 | 34,642 | Randy Wolf | Daniel Cabrera | Randy Wolf | Daniel Cabrera | | 190 | 210 | -20 |
| 2005-05-21 | @ BAL | 44 | L 0-7 | 20-24 | 5 | 42,331 | Vicente Padilla | Erik Bedard | Erik Bedard | Vicente Padilla | | 190 | 217 | -27 |
| 2005-05-22 | @ BAL | 45 | W 7-2 | 21-24 | 5 | 41,614 | Cory Lidle | Sidney Ponson | Cory Lidle | Sidney Ponson | | 197 | 219 | -22 |
| 2005-05-23 | @ FLO | 46 | L 2-5 | 21-25 | 5 | 11,944 | Jon Lieber | Dontrelle Willis | Dontrelle Willis | Jon Lieber | Todd Jones | 199 | 224 | -25 |
| 2005-05-24 | @ FLO | 47 | L 3-4 | 21-26 | 5 | 18,419 | Brett Myers | Josh Beckett | John Riedling | Amaury Telemaco | | 202 | 228 | -26 |
| 2005-05-25 | @ FLO | 48 | W 8-5 | 22-26 | 5 | 17,165 | Randy Wolf | Al Leiter | Randy Wolf | Al Leiter | Billy Wagner | 210 | 233 | -23 |
| 2005-05-27 | @ ATL | 49 | W 5-1 | 23-26 | 5 | 31,501 | Cory Lidle | John Smoltz | Cory Lidle | John Smoltz | | 215 | 234 | -19 |
| 2005-05-28 | @ ATL | 50 | W 12-5 | 24-26 | 5 | 34,975 | Jon Lieber | Horacio Ramirez | Jon Lieber | Horacio Ramirez | | 227 | 239 | -12 |
| 2005-05-29 | @ ATL | 51 | L 2-7 | 24-27 | 5 | 37,615 | Brett Myers | Tim Hudson | Tim Hudson | Brett Myers | | 229 | 246 | -17 |
| 2005-05-31 | vs SFN | 52 | W 5-2 | 25-27 | 5 | 23,456 | Randy Wolf | Brett Tomko | Randy Wolf | Brett Tomko | | 234 | 248 | -14 |
| 2005-06-01 | vs SFN | 53 | W 10-6 | 26-27 | 5 | 24,546 | Cory Lidle | Kirk Rueter | Ryan Madson | LaTroy Hawkins | | 244 | 254 | -10 |
| 2005-06-02 | vs SFN | 54 | W 6-5 | 27-27 | 5 | 25,589 | Jon Lieber | Brad Hennessey | Jon Lieber | Brad Hennessey | Billy Wagner | 250 | 259 | -9 |
| 2005-06-04 | vs ARI | 55 | W 10-6 | 29-27 | 5 | 0 | Vicente Padilla | Javier Vazquez | Vicente Padilla | Javier Vazquez | | 260 | 265 | -5 |
| 2005-06-04 | vs ARI | 56 | W 5-3 | 29-27 | 5 | 43,449 | Brett Myers | Russ Ortiz | Brett Myers | Russ Ortiz | Billy Wagner | 265 | 268 | -3 |
| 2005-06-05 | vs ARI | 57 | W 7-6 | 30-27 | 4 | 37,582 | Randy Wolf | Brad Halsey | Randy Wolf | Brad Halsey | Billy Wagner | 272 | 274 | -2 |
| 2005-06-06 | vs ARI | 58 | L 8-10 | 30-28 | 5 | 25,570 | Cory Lidle | Brandon Webb | Brandon Webb | Cory Lidle | Javier Lopez | 280 | 284 | -4 |
| 2005-06-07 | vs TEX | 59 | W 8-5 | 31-28 | 4 | 33,616 | Jon Lieber | Ryan Drese | Jon Lieber | Ryan Drese | Billy Wagner | 288 | 289 | -1 |
| 2005-06-08 | vs TEX | 60 | W 2-0 | 32-28 | 2 | 24,339 | Rob Tejeda | Chris Young | Aaron Fultz | Chris Young | Billy Wagner | 290 | 289 | 1 |
| 2005-06-09 | vs TEX | 61 | W 10-8 | 33-28 | 2 | 25,205 | Vicente Padilla | Pedro Astacio | Vicente Padilla | Pedro Astacio | Billy Wagner | 300 | 297 | 3 |
| 2005-06-10 | vs MIL | 62 | W 5-2 | 34-28 | 2 | 27,225 | Brett Myers | Victor Santos | Ryan Madson | Matt Wise | | 305 | 299 | 6 |
| 2005-06-11 | vs MIL | 63 | W 7-5 | 35-28 | 2 | 33,455 | Randy Wolf | Doug Davis | Rheal Cormier | Ricky Bottalico | Ugueth Urbina | 312 | 304 | 8 |
| 2005-06-12 | vs MIL | 64 | W 6-2 | 36-28 | 2 | 40,385 | Cory Lidle | Ben Sheets | Cory Lidle | Ben Sheets | | 318 | 306 | 12 |
| 2005-06-14 | @ SEA | 65 | L 1-3 | 36-29 | 2 | 26,818 | Jon Lieber | Gil Meche | Gil Meche | Jon Lieber | Eddie Guardado | 319 | 309 | 10 |
| 2005-06-15 | @ SEA | 66 | L 1-5 | 36-30 | 2 | 26,019 | Vicente Padilla | Aaron Sele | Aaron Sele | Vicente Padilla | | 320 | 314 | 6 |
| 2005-06-16 | @ SEA | 67 | W 3-2 | 37-30 | 2 | 27,162 | Brett Myers | Joel Pineiro | Geoff Geary | Julio Mateo | Billy Wagner | 323 | 316 | 7 |
| 2005-06-17 | @ OAK | 68 | W 6-1 | 38-30 | 2 | 15,601 | Rob Tejeda | Barry Zito | Rob Tejeda | Barry Zito | | 329 | 317 | 12 |
| 2005-06-18 | @ OAK | 69 | L 1-2 | 38-31 | 2 | 20,332 | Cory Lidle | Kirk Saarloos | Kirk Saarloos | Cory Lidle | Justin Duchscherer | 330 | 319 | 11 |
| 2005-06-19 | @ OAK | 70 | L 2-5 | 38-32 | 2 | 30,619 | Jon Lieber | Joe Blanton | Joe Blanton | Jon Lieber | Justin Duchscherer | 332 | 324 | 8 |
| 2005-06-21 | vs NYN | 71 | L 5-8 | 38-33 | 2 | 43,050 | Brett Myers | Kris Benson | Kris Benson | Brett Myers | Braden Looper | 337 | 332 | 5 |
| 2005-06-22 | vs NYN | 72 | W 8-4 | 39-33 | 2 | 42,640 | Rob Tejeda | Victor Zambrano | Ryan Madson | Royce Ring | | 345 | 336 | 9 |
| 2005-06-23 | vs NYN | 73 | L 3-4 | 39-34 | 2 | 45,449 | Cory Lidle | Kazuhisa Ishii | Kazuhisa Ishii | Cory Lidle | Braden Looper | 348 | 340 | 8 |
| 2005-06-24 | vs BOS | 74 | L 0-8 | 39-35 | 3 | 45,090 | Jon Lieber | Tim Wakefield | Tim Wakefield | Jon Lieber | | 348 | 348 | 0 |
| 2005-06-25 | vs BOS | 75 | L 1-7 | 39-36 | 4 | 44,868 | Vicente Padilla | Matt Clement | Matt Clement | Vicente Padilla | | 349 | 355 | -6 |
| 2005-06-26 | vs BOS | 76 | L 8-12 | 39-37 | 4 | 45,042 | Brett Myers | David Wells | Mike Timlin | Rheal Cormier | | 357 | 367 | -10 |
| 2005-06-28 | @ NYN | 77 | L 3-8 | 39-38 | 4 | 39,898 | Rob Tejeda | Victor Zambrano | Victor Zambrano | Rob Tejeda | | 360 | 375 | -15 |
| 2005-06-29 | @ NYN | 78 | W 6-3 | 40-38 | 4 | 24,915 | Cory Lidle | Kazuhisa Ishii | Cory Lidle | Kazuhisa Ishii | Billy Wagner | 366 | 378 | -12 |
| 2005-06-30 | @ NYN | 79 | L 3-5 | 40-39 | 4 | 36,667 | Jon Lieber | Pedro Martinez | Pedro Martinez | Jon Lieber | Braden Looper | 369 | 383 | -14 |
| 2005-07-01 | vs ATL | 80 | L 1-9 | 40-40 | 5 | 45,004 | Vicente Padilla | John Smoltz | John Smoltz | Vicente Padilla | | 370 | 392 | -22 |
| 2005-07-02 | vs ATL | 81 | W 6-3 | 41-40 | 4 | 29,205 | Brett Myers | Horacio Ramirez | Brett Myers | Horacio Ramirez | Billy Wagner | 376 | 395 | -19 |
| 2005-07-03 | vs ATL | 82 | L 3-4 | 41-41 | 4 | 39,732 | Rob Tejeda | Jorge Sosa | Jim Brower | Billy Wagner | Chris Reitsma | 379 | 399 | -20 |
| 2005-07-04 | @ PIT | 83 | W 12-1 | 42-41 | 4 | 37,259 | Cory Lidle | David Williams | Cory Lidle | David Williams | | 391 | 400 | -9 |
| 2005-07-05 | @ PIT | 84 | L 0-3 | 42-42 | 4 | 13,442 | Jon Lieber | Kip Wells | Kip Wells | Ryan Madson | | 391 | 403 | -12 |
| 2005-07-06 | @ PIT | 85 | W 5-0 | 43-42 | 4 | 19,961 | Vicente Padilla | Mark Redman | Vicente Padilla | Mark Redman | | 396 | 403 | -7 |
| 2005-07-07 | @ PIT | 86 | L 1-2 | 43-43 | 5 | 20,942 | Brett Myers | Zach Duke | Zach Duke | Brett Myers | Jose Mesa | 397 | 405 | -8 |
| 2005-07-08 | vs WAS | 87 | L 7-8 | 43-44 | 5 | 44,688 | Rob Tejeda | Ryan Drese | Ryan Drese | Rob Tejeda | Chad Cordero | 404 | 413 | -9 |
| 2005-07-09 | vs WAS | 88 | W 1-0 | 44-44 | 4 | 33,365 | Cory Lidle | John Patterson | Billy Wagner | Hector Carrasco | | 405 | 413 | -8 |
| 2005-07-10 | vs WAS | 89 | W 5-4 | 45-44 | 4 | 34,124 | Jon Lieber | Esteban Loaiza | Rheal Cormier | Sun-Woo Kim | | 410 | 417 | -7 |
| 2005-07-14 | vs FLO | 90 | W 13-7 | 46-44 | 3 | 29,660 | Brett Myers | A.J. Burnett | Brett Myers | A.J. Burnett | | 423 | 424 | -1 |
| 2005-07-15 | vs FLO | 91 | L 7-9 | 46-45 | 4 | 30,233 | Cory Lidle | Brian Moehler | Brian Moehler | Cory Lidle | Todd Jones | 430 | 433 | -3 |
| 2005-07-16 | vs FLO | 92 | W 10-5 | 47-45 | 3 | 33,268 | Jon Lieber | Scott Olsen | Jon Lieber | Scott Olsen | | 440 | 438 | 2 |
| 2005-07-17 | vs FLO | 93 | W 8-4 | 48-45 | 3 | 36,419 | Vicente Padilla | Dontrelle Willis | Vicente Padilla | Dontrelle Willis | | 448 | 442 | 6 |
| 2005-07-19 | vs LAN | 94 | W 5-4 | 49-45 | 3 | 29,349 | Brett Myers | Brad Penny | Billy Wagner | Yhency Brazoban | | 453 | 446 | 7 |
| 2005-07-20 | vs LAN | 95 | L 2-10 | 49-46 | 3 | 31,164 | Cory Lidle | Derek Lowe | Derek Lowe | Cory Lidle | | 455 | 456 | -1 |
| 2005-07-21 | vs LAN | 96 | L 0-1 | 49-47 | 4 | 36,232 | Jon Lieber | Odalis Perez | Odalis Perez | Jon Lieber | Yhency Brazoban | 455 | 457 | -2 |
| 2005-07-22 | vs SDN | 97 | W 8-6 | 50-47 | 3 | 28,600 | Vicente Padilla | Tim Stauffer | Aaron Fultz | Paul Quantrill | | 463 | 463 | 0 |
| 2005-07-23 | vs SDN | 98 | W 2-0 | 51-47 | 3 | 33,992 | Rob Tejeda | Pedro Astacio | Rob Tejeda | Pedro Astacio | Billy Wagner | 465 | 463 | 2 |
| 2005-07-24 | vs SDN | 99 | W 5-1 | 52-47 | 3 | 35,322 | Brett Myers | Brian Lawrence | Brett Myers | Brian Lawrence | | 470 | 464 | 6 |
| 2005-07-25 | @ HOU | 100 | L 1-7 | 52-48 | 3 | 36,029 | Cory Lidle | Andy Pettitte | Andy Pettitte | Cory Lidle | | 471 | 471 | 0 |
| 2005-07-26 | @ HOU | 101 | L 1-2 | 52-49 | 3 | 33,867 | Jon Lieber | Roy Oswalt | Roy Oswalt | Ryan Madson | | 472 | 473 | -1 |
| 2005-07-27 | @ HOU | 102 | L 2-3 | 52-50 | 5 | 38,071 | Vicente Padilla | Roger Clemens | Roger Clemens | Vicente Padilla | Brad Lidge | 474 | 476 | -2 |
| 2005-07-28 | @ COL | 103 | W 8-5 | 53-50 | 4 | 22,015 | Rob Tejeda | Byung-Hyun Kim | Ugueth Urbina | Mike DeJean | Billy Wagner | 482 | 481 | 1 |
| 2005-07-29 | @ COL | 104 | W 5-3 | 54-50 | 4 | 21,855 | Brett Myers | Jose Acevedo | Brett Myers | Jose Acevedo | Billy Wagner | 487 | 484 | 3 |
| 2005-07-30 | @ COL | 105 | W 8-7 | 55-50 | 4 | 33,418 | Cory Lidle | Aaron Cook | Cory Lidle | Aaron Cook | Billy Wagner | 495 | 491 | 4 |
| 2005-07-31 | @ COL | 106 | L 2-9 | 55-51 | 4 | 21,807 | Jon Lieber | Jeff Francis | Jeff Francis | Jon Lieber | | 497 | 500 | -3 |
| 2005-08-02 | vs CHN | 107 | L 1-2 | 55-52 | 4 | 32,585 | Vicente Padilla | Carlos Zambrano | Carlos Zambrano | Vicente Padilla | Ryan Dempster | 498 | 502 | -4 |
| 2005-08-03 | vs CHN | 108 | W 4-3 | 56-52 | 3 | 34,727 | Rob Tejeda | Jerome Williams | Billy Wagner | Mike Remlinger | | 502 | 505 | -3 |
| 2005-08-04 | vs CHN | 109 | W 6-4 | 57-52 | 3 | 37,882 | Brett Myers | Mark Prior | Brett Myers | Mark Prior | Billy Wagner | 508 | 509 | -1 |
| 2005-08-05 | vs MIL | 110 | L 1-3 | 57-53 | 4 | 31,759 | Cory Lidle | Ben Sheets | Ben Sheets | Geoff Geary | Matt Wise | 509 | 512 | -3 |
| 2005-08-06 | vs MIL | 111 | W 8-2 | 58-53 | 3 | 35,800 | Jon Lieber | Chris Capuano | Jon Lieber | Chris Capuano | | 517 | 514 | 3 |
| 2005-08-07 | vs MIL | 112 | L 0-2 | 58-54 | 4 | 35,017 | Vicente Padilla | Tomo Ohka | Tomo Ohka | Vicente Padilla | Derrick Turnbow | 517 | 516 | 1 |
| 2005-08-09 | @ LAN | 113 | W 8-4 | 59-54 | 3 | 44,556 | Rob Tejeda | Brad Penny | Ryan Madson | Steve Schmoll | | 525 | 520 | 5 |
| 2005-08-10 | @ LAN | 114 | W 9-5 | 60-54 | 2 | 44,001 | Brett Myers | Derek Lowe | Ugueth Urbina | Yhency Brazoban | | 534 | 525 | 9 |
| 2005-08-11 | @ LAN | 115 | L 1-5 | 60-55 | 2 | 44,963 | Cory Lidle | Odalis Perez | Odalis Perez | Cory Lidle | | 535 | 530 | 5 |
| 2005-08-12 | @ SDN | 116 | W 3-2 | 61-55 | 2 | 41,153 | Jon Lieber | Jake Peavy | Jon Lieber | Jake Peavy | Billy Wagner | 538 | 532 | 6 |
| 2005-08-13 | @ SDN | 117 | W 5-2 | 62-55 | 2 | 37,777 | Vicente Padilla | Pedro Astacio | Ugueth Urbina | Trevor Hoffman | Billy Wagner | 543 | 534 | 9 |
| 2005-08-14 | @ SDN | 118 | W 8-3 | 63-55 | 2 | 37,167 | Rob Tejeda | Chan Ho Park | Rob Tejeda | Chan Ho Park | | 551 | 537 | 14 |
| 2005-08-15 | vs WAS | 119 | L 3-6 | 63-56 | 3 | 40,627 | Brett Myers | Livan Hernandez | Livan Hernandez | Brett Myers | | 554 | 543 | 11 |
| 2005-08-17 | vs WAS | 120 | W 4-3 | 64-56 | 2 | 33,450 | Jon Lieber | Esteban Loaiza | Jon Lieber | Esteban Loaiza | Billy Wagner | 558 | 546 | 12 |
| 2005-08-18 | vs WAS | 121 | W 2-1 | 65-57 | 2 | 30,046 | Vicente Padilla | Tony Armas | Vicente Padilla | Tony Armas | Billy Wagner | 560 | 547 | 13 |
| 2005-08-18 | vs WAS | 122 | L 4-5 | 65-57 | 2 | 34,492 | Cory Lidle | Ryan Drese | Luis Ayala | Ugueth Urbina | Chad Cordero | 564 | 552 | 12 |
| 2005-08-19 | vs PIT | 123 | L 2-11 | 65-58 | 3 | 32,992 | Rob Tejeda | Kip Wells | Kip Wells | Rob Tejeda | | 566 | 563 | 3 |
| 2005-08-20 | vs PIT | 124 | W 6-1 | 66-58 | 2 | 43,192 | Brett Myers | David Williams | Brett Myers | David Williams | | 572 | 564 | 8 |
| 2005-08-21 | vs PIT | 125 | W 4-3 | 67-58 | 2 | 40,689 | Eude Brito | Mark Redman | Ryan Madson | Rick White | Billy Wagner | 576 | 567 | 9 |
| 2005-08-22 | @ SFN | 126 | L 0-5 | 67-59 | 3 | 38,947 | Jon Lieber | Noah Lowry | Noah Lowry | Jon Lieber | | 576 | 572 | 4 |
| 2005-08-23 | @ SFN | 127 | W 10-2 | 68-59 | 2 | 37,892 | Vicente Padilla | Brett Tomko | Vicente Padilla | Brett Tomko | | 586 | 574 | 12 |
| 2005-08-24 | @ SFN | 128 | W 7-4 | 69-59 | 2 | 36,812 | Cory Lidle | Brad Hennessey | Rob Tejeda | Brad Hennessey | Billy Wagner | 593 | 578 | 15 |
| 2005-08-26 | @ ARI | 129 | W 11-3 | 70-59 | 2 | 22,397 | Brett Myers | Brad Halsey | Aaron Fultz | Brad Halsey | | 604 | 581 | 23 |
| 2005-08-27 | @ ARI | 130 | L 0-2 | 70-60 | 2 | 26,903 | Jon Lieber | Brandon Webb | Brandon Webb | Jon Lieber | Jose Valverde | 604 | 583 | 21 |
| 2005-08-28 | @ ARI | 131 | L 5-10 | 70-61 | 2 | 31,112 | Vicente Padilla | Claudio Vargas | Claudio Vargas | Vicente Padilla | | 609 | 593 | 16 |
| 2005-08-30 | @ NYN | 132 | L 4-6 | 70-62 | 3 | 36,505 | Rob Tejeda | Jae Weong Seo | Juan Padilla | Ugueth Urbina | Braden Looper | 613 | 599 | 14 |
| 2005-08-31 | @ NYN | 133 | W 8-2 | 71-62 | 2 | 43,780 | Brett Myers | Pedro Martinez | Brett Myers | Pedro Martinez | | 621 | 601 | 20 |
| 2005-09-01 | @ NYN | 134 | W 3-1 | 72-62 | 2 | 38,316 | Jon Lieber | Tom Glavine | Jon Lieber | Tom Glavine | Billy Wagner | 624 | 602 | 22 |
| 2005-09-02 | @ WAS | 135 | W 7-1 | 73-62 | 2 | 28,939 | Vicente Padilla | John Halama | Vicente Padilla | John Halama | | 631 | 603 | 28 |
| 2005-09-03 | @ WAS | 136 | L 4-5 | 73-63 | 2 | 30,561 | Eude Brito | John Patterson | Hector Carrasco | Aquilino Lopez | | 635 | 608 | 27 |
| 2005-09-04 | @ WAS | 137 | L 1-6 | 73-64 | 2 | 32,251 | Gavin Floyd | Esteban Loaiza | Esteban Loaiza | Gavin Floyd | | 636 | 614 | 22 |
| 2005-09-05 | vs HOU | 138 | L 3-4 | 73-65 | 2 | 36,144 | Brett Myers | Andy Pettitte | Andy Pettitte | Brett Myers | Brad Lidge | 639 | 618 | 21 |
| 2005-09-06 | vs HOU | 139 | L 1-2 | 73-66 | 3 | 30,600 | Jon Lieber | Roy Oswalt | Roy Oswalt | Billy Wagner | Brad Lidge | 640 | 620 | 20 |
| 2005-09-07 | vs HOU | 140 | L 6-8 | 73-67 | 3 | 29,026 | Vicente Padilla | Brandon Backe | Chad Qualls | Billy Wagner | Brad Lidge | 646 | 628 | 18 |
| 2005-09-09 | vs FLO | 141 | W 12-5 | 74-67 | 3 | 32,933 | Cory Lidle | A.J. Burnett | Cory Lidle | A.J. Burnett | | 658 | 633 | 25 |
| 2005-09-10 | vs FLO | 142 | L 6-7 | 74-68 | 3 | 40,479 | Brett Myers | Jason Vargas | Chris Resop | Ryan Madson | Todd Jones | 664 | 640 | 24 |
| 2005-09-11 | vs FLO | 143 | W 11-1 | 75-68 | 3 | 34,794 | Jon Lieber | Ismael Valdez | Jon Lieber | Ismael Valdez | | 675 | 641 | 34 |
| 2005-09-12 | vs ATL | 144 | W 4-1 | 76-68 | 3 | 21,169 | Eude Brito | Tim Hudson | Eude Brito | Tim Hudson | Billy Wagner | 679 | 642 | 37 |
| 2005-09-13 | vs ATL | 145 | W 5-4 | 77-68 | 3 | 24,311 | Gavin Floyd | John Thomson | Aaron Fultz | Blaine Boyer | Billy Wagner | 684 | 646 | 38 |
| 2005-09-14 | vs ATL | 146 | W 12-4 | 78-68 | 3 | 23,125 | Cory Lidle | Horacio Ramirez | Cory Lidle | Horacio Ramirez | | 696 | 650 | 46 |
| 2005-09-15 | vs ATL | 147 | L 4-6 | 78-69 | 3 | 27,804 | Brett Myers | Jorge Sosa | Jorge Sosa | Brett Myers | Kyle Farnsworth | 700 | 656 | 44 |
| 2005-09-16 | @ FLO | 148 | W 13-3 | 79-69 | 2 | 30,853 | Jon Lieber | Brian Moehler | Jon Lieber | Jim Mecir | | 713 | 659 | 54 |
| 2005-09-17 | @ FLO | 149 | W 10-2 | 80-69 | 2 | 27,203 | Vicente Padilla | Dontrelle Willis | Ugueth Urbina | Dontrelle Willis | | 723 | 661 | 62 |
| 2005-09-18 | @ FLO | 150 | L 6-14 | 80-70 | 2 | 25,208 | Eude Brito | Josh Beckett | Josh Beckett | Eude Brito | | 729 | 675 | 54 |
| 2005-09-20 | @ ATL | 151 | L 1-4 | 80-71 | 2 | 25,701 | Cory Lidle | Jorge Sosa | Jorge Sosa | Cory Lidle | | 730 | 679 | 51 |
| 2005-09-21 | @ ATL | 152 | W 10-6 | 81-71 | 2 | 27,030 | Brett Myers | Horacio Ramirez | Geoff Geary | Kyle Davies | | 740 | 685 | 55 |
| 2005-09-22 | @ ATL | 153 | W 4-0 | 82-71 | 2 | 26,301 | Jon Lieber | Tim Hudson | Jon Lieber | Tim Hudson | | 744 | 685 | 59 |
| 2005-09-23 | @ CIN | 154 | W 11-10 | 83-71 | 2 | 22,608 | Vicente Padilla | Aaron Harang | Rheal Cormier | David Weathers | Billy Wagner | 755 | 695 | 60 |
| 2005-09-24 | @ CIN | 155 | L 2-3 | 83-72 | 2 | 31,632 | Eude Brito | Eric Milton | Eric Milton | Eude Brito | David Weathers | 757 | 698 | 59 |
| 2005-09-25 | @ CIN | 156 | W 6-3 | 84-72 | 2 | 23,072 | Cory Lidle | Randy Keisler | Cory Lidle | Randy Keisler | Billy Wagner | 763 | 701 | 62 |
| 2005-09-26 | vs NYN | 157 | L 5-6 | 84-73 | 2 | 28,679 | Brett Myers | Jae Weong Seo | Shingo Takatsu | Ugueth Urbina | Roberto Hernandez | 768 | 707 | 61 |
| 2005-09-27 | vs NYN | 158 | L 2-3 | 84-74 | 2 | 36,150 | Jon Lieber | Victor Zambrano | Juan Padilla | Jon Lieber | Aaron Heilman | 770 | 710 | 60 |
| 2005-09-28 | vs NYN | 159 | W 16-6 | 85-74 | 2 | 42,250 | Vicente Padilla | Steve Trachsel | Vicente Padilla | Steve Trachsel | | 786 | 716 | 70 |
| 2005-09-30 | @ WAS | 160 | W 4-3 | 86-74 | 2 | 30,375 | Cory Lidle | Livan Hernandez | Cory Lidle | Livan Hernandez | Billy Wagner | 790 | 719 | 71 |
| 2005-10-01 | @ WAS | 161 | W 8-4 | 87-74 | 2 | 32,903 | Brett Myers | John Patterson | Brett Myers | John Patterson | | 798 | 723 | 75 |
| 2005-10-02 | @ WAS | 162 | W 9-3 | 88-74 | 2 | 36,491 | Jon Lieber | Hector Carrasco | Jon Lieber | Hector Carrasco | Billy Wagner | 807 | 726 | 81 |