| East | W | L | Pct | GB |
| Boston | 95 | 67 | .586 | -- |
| NY Yankees | 95 | 67 | .586 | -- |
| Toronto | 80 | 82 | .494 | 15.0 |
| Baltimore | 74 | 88 | .457 | 21.0 |
| Tampa Bay | 67 | 95 | .414 | 28.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2005-04-03 | Randy Johnson | L | 42 | L 9-2 | vs BOS | 1 | 480 | W | 6.0 | 5 | 1 | 1 | 0 | 2 | 6 | 95 | 35 | 60 | 63% | 1-0 | 1.50 | 1.17 |
| 2005-04-05 | Carl Pavano | R | 29 | L 4-3 | vs BOS | 1 | 150 | - | 6.1 | 8 | 2 | 2 | 1 | 1 | 7 | 87 | 31 | 56 | 64% | 0-0 | 3.00 | 1.50 |
| 2005-04-06 | Mike Mussina | R | 36 | W 3-7 | vs BOS | 1 | 414 | - | 6.0 | 9 | 2 | 2 | 0 | 2 | 2 | 96 | 40 | 56 | 58% | 0-0 | 3.00 | 1.83 |
| 2005-04-08 | Jaret Wright | R | 29 | W 5-12 | vs BAL | 1 | 129 | L | 4.0 | 8 | 6 | 6 | 1 | 1 | 4 | 81 | 31 | 50 | 62% | 0-1 | 13.50 | 2.25 |
| 2005-04-09 | Randy Johnson | L | 42 | L 8-5 | vs BAL | 2 | 481 | - | 6.0 | 8 | 5 | 4 | 0 | 1 | 4 | 99 | 34 | 65 | 66% | 1-0 | 3.75 | 1.33 |
| 2005-04-10 | Carl Pavano | R | 29 | W 2-7 | vs BAL | 2 | 151 | L | 2.0 | 5 | 3 | 1 | 0 | 0 | 1 | 40 | 14 | 26 | 65% | 0-1 | 3.38 | 1.75 |
| 2005-04-11 | Mike Mussina | R | 36 | L 1-8 | @ BOS | 2 | 415 | L | 5.0 | 7 | 7 | 4 | 1 | 3 | 5 | 95 | 41 | 54 | 57% | 0-1 | 4.91 | 1.91 |
| 2005-04-13 | Jaret Wright | R | 29 | W 5-2 | @ BOS | 2 | 130 | W | 5.0 | 6 | 2 | 2 | 1 | 4 | 2 | 97 | 48 | 49 | 51% | 1-1 | 8.00 | 2.11 |
| 2005-04-14 | Randy Johnson | L | 42 | L 5-8 | @ BOS | 3 | 482 | - | 7.0 | 5 | 5 | 5 | 3 | 2 | 9 | 103 | 36 | 67 | 65% | 1-0 | 4.74 | 1.21 |
| 2005-04-15 | Carl Pavano | R | 29 | L 1-8 | @ BAL | 3 | 152 | L | 5.2 | 7 | 7 | 3 | 2 | 2 | 3 | 94 | 35 | 59 | 63% | 0-2 | 3.86 | 1.64 |
| 2005-04-16 | Mike Mussina | R | 36 | L 6-7 | @ BAL | 3 | 416 | - | 5.2 | 7 | 2 | 2 | 0 | 3 | 4 | 108 | 42 | 66 | 61% | 0-1 | 4.24 | 1.82 |
| 2005-04-17 | Kevin Brown | R | 40 | L 4-8 | @ BAL | 1 | 464 | L | 6.0 | 9 | 6 | 6 | 2 | 2 | 3 | 87 | 35 | 52 | 60% | 0-1 | 9.00 | 1.83 |
| 2005-04-18 | Jaret Wright | R | 29 | L 19-8 | vs TBA | 3 | 131 | W | 5.1 | 11 | 8 | 8 | 1 | 3 | 4 | 107 | 46 | 61 | 57% | 2-1 | 10.29 | 2.36 |
| 2005-04-19 | Randy Johnson | L | 42 | W 2-6 | vs TBA | 4 | 483 | L | 7.1 | 6 | 6 | 5 | 2 | 0 | 8 | 103 | 35 | 68 | 66% | 1-1 | 5.19 | 1.12 |
| 2005-04-20 | Carl Pavano | R | 29 | W 11-2 | @ TOR | 4 | 153 | W | 8.0 | 7 | 2 | 1 | 0 | 0 | 3 | 92 | 33 | 59 | 64% | 1-2 | 2.86 | 1.36 |
| 2005-04-21 | Mike Mussina | R | 36 | W 4-3 | @ TOR | 4 | 417 | W | 5.1 | 10 | 3 | 3 | 0 | 1 | 5 | 99 | 39 | 60 | 61% | 1-1 | 4.50 | 1.91 |
| 2005-04-22 | Kevin Brown | R | 40 | W 3-5 | vs TEX | 2 | 465 | L | 6.0 | 11 | 5 | 5 | 0 | 1 | 4 | 93 | 35 | 58 | 62% | 0-2 | 8.25 | 1.92 |
| 2005-04-23 | Jaret Wright | R | 29 | W 2-10 | vs TEX | 4 | 132 | L | 5.1 | 11 | 6 | 4 | 3 | 1 | 3 | 93 | 37 | 56 | 60% | 2-2 | 9.00 | 2.25 |
| 2005-04-24 | Randy Johnson | L | 42 | L 11-1 | vs TEX | 5 | 484 | W | 8.0 | 3 | 1 | 1 | 0 | 1 | 7 | 101 | 43 | 58 | 57% | 2-1 | 4.24 | 0.97 |
| 2005-04-26 | Carl Pavano | R | 29 | L 12-4 | vs ANA | 5 | 154 | W | 7.0 | 7 | 3 | 3 | 0 | 2 | 2 | 98 | 38 | 60 | 61% | 2-2 | 3.10 | 1.34 |
| 2005-04-27 | Mike Mussina | R | 36 | W 1-5 | vs ANA | 5 | 418 | L | 7.0 | 10 | 5 | 5 | 2 | 1 | 2 | 103 | 40 | 63 | 61% | 1-2 | 4.97 | 1.83 |
| 2005-04-28 | Kevin Brown | R | 40 | W 1-3 | vs ANA | 3 | 466 | L | 7.0 | 8 | 3 | 3 | 0 | 1 | 5 | 107 | 40 | 67 | 63% | 0-3 | 6.63 | 1.68 |
| 2005-04-29 | Randy Johnson | L | 42 | W 0-2 | vs TOR | 6 | 485 | L | 9.0 | 7 | 2 | 2 | 1 | 3 | 9 | 108 | 38 | 70 | 65% | 2-2 | 3.77 | 1.00 |
| 2005-04-30 | Chien-Ming Wang | R | 25 | L 4-3 | vs TOR | 1 | 1 | - | 7.0 | 6 | 2 | 2 | 0 | 2 | 0 | 81 | 27 | 54 | 67% | 0-0 | 2.57 | 1.14 |
| 2005-05-01 | Carl Pavano | R | 29 | W 6-8 | vs TOR | 6 | 155 | - | 5.0 | 9 | 6 | 6 | 1 | 1 | 2 | 90 | 38 | 52 | 58% | 2-2 | 4.24 | 1.44 |
| 2005-05-02 | Mike Mussina | R | 36 | W 6-2 | @ TBA | 6 | 419 | W | 7.0 | 5 | 2 | 2 | 1 | 2 | 2 | 121 | 47 | 74 | 61% | 2-2 | 4.50 | 1.67 |
| 2005-05-03 | Kevin Brown | R | 40 | L 4-11 | @ TBA | 4 | 467 | L | 5.0 | 13 | 8 | 8 | 0 | 0 | 2 | 95 | 33 | 62 | 65% | 0-4 | 8.25 | 1.88 |
| 2005-05-04 | Sean Henn | L | 24 | L 8-11 | @ TBA | 1 | 1 | L | 2.1 | 7 | 6 | 5 | 0 | 2 | 0 | 73 | 31 | 42 | 58% | 0-1 | 22.50 | 4.50 |
| 2005-05-05 | Chien-Ming Wang | R | 25 | L 2-6 | @ TBA | 2 | 2 | L | 6.0 | 8 | 5 | 5 | 0 | 2 | 3 | 83 | 34 | 49 | 59% | 0-1 | 4.85 | 1.38 |
| 2005-05-06 | Carl Pavano | R | 29 | W 3-6 | vs OAK | 7 | 156 | - | 7.0 | 7 | 3 | 3 | 2 | 3 | 3 | 101 | 43 | 58 | 57% | 2-2 | 4.17 | 1.44 |
| 2005-05-07 | Mike Mussina | R | 36 | L 5-0 | vs OAK | 7 | 420 | W | 9.0 | 4 | 0 | 0 | 0 | 2 | 3 | 131 | 48 | 83 | 63% | 3-2 | 3.60 | 1.47 |
| 2005-05-08 | Kevin Brown | R | 40 | L 6-0 | vs OAK | 5 | 468 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 4 | 106 | 37 | 69 | 65% | 1-4 | 6.39 | 1.65 |
| 2005-05-09 | Randy Johnson | L | 42 | L 4-3 | vs SEA | 7 | 486 | W | 8.0 | 7 | 3 | 3 | 1 | 2 | 7 | 115 | 40 | 75 | 65% | 3-2 | 3.71 | 1.02 |
| 2005-05-10 | Chien-Ming Wang | R | 25 | L 7-4 | vs SEA | 3 | 3 | W | 7.1 | 4 | 3 | 3 | 0 | 3 | 3 | 107 | 46 | 61 | 57% | 1-1 | 4.50 | 1.25 |
| 2005-05-11 | Carl Pavano | R | 29 | L 13-9 | vs SEA | 8 | 157 | - | 4.0 | 10 | 9 | 5 | 4 | 1 | 6 | 85 | 28 | 57 | 67% | 2-2 | 4.80 | 1.56 |
| 2005-05-13 | Mike Mussina | R | 36 | W 9-4 | @ OAK | 8 | 421 | W | 7.0 | 6 | 2 | 2 | 0 | 1 | 9 | 113 | 39 | 74 | 65% | 4-2 | 3.46 | 1.40 |
| 2005-05-14 | Kevin Brown | R | 40 | W 15-6 | @ OAK | 6 | 469 | W | 6.0 | 8 | 5 | 3 | 0 | 0 | 1 | 103 | 34 | 69 | 67% | 2-4 | 6.08 | 1.59 |
| 2005-05-15 | Randy Johnson | L | 42 | W 6-4 | @ OAK | 8 | 487 | W | 6.0 | 7 | 4 | 3 | 0 | 1 | 0 | 102 | 37 | 65 | 64% | 4-2 | 3.79 | 1.05 |
| 2005-05-16 | Chien-Ming Wang | R | 25 | W 6-3 | @ SEA | 4 | 4 | W | 6.1 | 6 | 3 | 3 | 0 | 0 | 4 | 90 | 35 | 55 | 61% | 2-1 | 4.33 | 1.15 |
| 2005-05-17 | Carl Pavano | R | 29 | W 6-0 | @ SEA | 9 | 158 | W | 9.0 | 5 | 0 | 0 | 0 | 0 | 7 | 132 | 43 | 89 | 67% | 3-2 | 4.00 | 1.39 |
| 2005-05-18 | Mike Mussina | R | 36 | L 6-7 | @ SEA | 9 | 422 | - | 5.0 | 7 | 4 | 4 | 0 | 0 | 6 | 104 | 33 | 71 | 68% | 4-2 | 3.79 | 1.40 |
| 2005-05-20 | Kevin Brown | R | 40 | W 5-2 | @ NYN | 7 | 470 | W | 5.0 | 3 | 1 | 0 | 0 | 4 | 5 | 96 | 45 | 51 | 53% | 3-4 | 5.36 | 1.57 |
| 2005-05-21 | Randy Johnson | L | 42 | L 1-7 | @ NYN | 9 | 488 | L | 6.2 | 12 | 4 | 4 | 1 | 0 | 5 | 108 | 34 | 74 | 69% | 4-3 | 3.94 | 1.13 |
| 2005-05-22 | Carl Pavano | R | 29 | W 5-3 | @ NYN | 10 | 159 | W | 7.0 | 8 | 3 | 1 | 1 | 1 | 3 | 99 | 40 | 59 | 60% | 4-2 | 3.69 | 1.38 |
| 2005-05-24 | Mike Mussina | R | 36 | L 12-3 | vs DET | 10 | 423 | W | 7.0 | 6 | 0 | 0 | 0 | 0 | 6 | 93 | 26 | 67 | 72% | 5-2 | 3.38 | 1.34 |
| 2005-05-25 | Chien-Ming Wang | R | 25 | L 4-2 | vs DET | 5 | 5 | W | 6.1 | 5 | 2 | 2 | 0 | 0 | 2 | 77 | 27 | 50 | 65% | 3-1 | 4.09 | 1.09 |
| 2005-05-26 | Kevin Brown | R | 40 | L 4-3 | vs DET | 8 | 471 | W | 7.0 | 10 | 3 | 3 | 0 | 0 | 4 | 94 | 29 | 65 | 69% | 4-4 | 5.14 | 1.55 |
| 2005-05-27 | Randy Johnson | L | 42 | L 6-3 | vs BOS | 10 | 489 | W | 6.0 | 9 | 3 | 3 | 1 | 4 | 3 | 104 | 36 | 68 | 65% | 5-3 | 3.99 | 1.21 |
| 2005-05-28 | Carl Pavano | R | 29 | W 1-17 | vs BOS | 11 | 160 | L | 3.2 | 11 | 5 | 5 | 0 | 1 | 2 | 87 | 31 | 56 | 64% | 4-3 | 4.15 | 1.48 |
| 2005-05-29 | Mike Mussina | R | 36 | W 2-7 | vs BOS | 11 | 424 | L | 3.0 | 7 | 5 | 5 | 3 | 2 | 2 | 83 | 33 | 50 | 60% | 5-3 | 3.90 | 1.42 |
| 2005-05-31 | Kevin Brown | R | 40 | L 3-5 | @ KCA | 9 | 472 | L | 7.0 | 9 | 5 | 4 | 0 | 3 | 7 | 125 | 44 | 81 | 65% | 4-5 | 5.14 | 1.57 |
| 2005-06-01 | Randy Johnson | L | 42 | L 1-3 | @ KCA | 11 | 490 | L | 8.0 | 9 | 3 | 3 | 1 | 1 | 7 | 108 | 34 | 74 | 69% | 5-4 | 3.92 | 1.22 |
| 2005-06-02 | Carl Pavano | R | 29 | L 2-5 | @ KCA | 12 | 161 | L | 5.1 | 9 | 5 | 5 | 2 | 0 | 2 | 91 | 34 | 57 | 63% | 4-4 | 4.50 | 1.50 |
| 2005-06-03 | Mike Mussina | R | 36 | L 3-6 | @ MIN | 12 | 425 | L | 6.0 | 8 | 6 | 6 | 2 | 2 | 1 | 78 | 31 | 47 | 60% | 5-4 | 4.32 | 1.44 |
| 2005-06-04 | Chien-Ming Wang | R | 25 | W 4-3 | @ MIN | 6 | 6 | - | 7.0 | 5 | 3 | 3 | 1 | 1 | 1 | 93 | 33 | 60 | 65% | 3-1 | 4.00 | 1.09 |
| 2005-06-05 | Kevin Brown | R | 40 | L 3-9 | @ MIN | 10 | 473 | L | 5.1 | 8 | 5 | 5 | 0 | 2 | 4 | 106 | 39 | 67 | 63% | 4-6 | 5.46 | 1.61 |
| 2005-06-06 | Randy Johnson | L | 42 | L 3-4 | @ MIL | 12 | 491 | L | 6.0 | 7 | 4 | 4 | 2 | 3 | 8 | 117 | 47 | 70 | 60% | 5-5 | 4.07 | 1.25 |
| 2005-06-07 | Carl Pavano | R | 29 | L 1-2 | @ MIL | 13 | 162 | L | 6.0 | 5 | 2 | 2 | 1 | 2 | 3 | 74 | 30 | 44 | 59% | 4-5 | 4.38 | 1.47 |
| 2005-06-08 | Mike Mussina | R | 36 | W 12-3 | @ MIL | 13 | 426 | W | 6.0 | 6 | 3 | 3 | 1 | 1 | 8 | 104 | 32 | 72 | 69% | 6-4 | 4.33 | 1.42 |
| 2005-06-10 | Chien-Ming Wang | R | 25 | L 1-8 | @ SLN | 7 | 7 | L | 4.0 | 7 | 7 | 4 | 0 | 5 | 2 | 84 | 40 | 44 | 52% | 3-2 | 4.41 | 1.24 |
| 2005-06-11 | Randy Johnson | L | 42 | W 5-0 | @ SLN | 13 | 492 | W | 7.0 | 4 | 0 | 0 | 0 | 0 | 7 | 97 | 30 | 67 | 69% | 6-5 | 3.76 | 1.20 |
| 2005-06-12 | Carl Pavano | R | 29 | L 3-5 | @ SLN | 14 | 163 | - | 6.0 | 6 | 1 | 1 | 0 | 1 | 2 | 100 | 41 | 59 | 59% | 4-5 | 4.17 | 1.45 |
| 2005-06-14 | Mike Mussina | R | 37 | L 9-0 | vs PIT | 14 | 427 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 6 | 109 | 33 | 76 | 70% | 7-4 | 3.89 | 1.34 |
| 2005-06-15 | Kevin Brown | R | 40 | L 7-5 | vs PIT | 11 | 474 | - | 4.1 | 7 | 3 | 3 | 0 | 1 | 6 | 82 | 32 | 50 | 61% | 4-6 | 5.45 | 1.61 |
| 2005-06-16 | Randy Johnson | L | 42 | L 6-1 | vs PIT | 14 | 493 | W | 9.0 | 5 | 1 | 1 | 1 | 0 | 11 | 108 | 24 | 84 | 78% | 7-5 | 3.51 | 1.14 |
| 2005-06-17 | Carl Pavano | R | 29 | L 9-6 | vs CHN | 15 | 164 | - | 5.1 | 10 | 6 | 6 | 0 | 1 | 3 | 83 | 28 | 55 | 66% | 4-5 | 4.55 | 1.49 |
| 2005-06-18 | Chien-Ming Wang | R | 25 | L 8-1 | vs CHN | 8 | 8 | W | 8.0 | 5 | 1 | 1 | 1 | 1 | 5 | 88 | 31 | 57 | 65% | 4-2 | 3.95 | 1.18 |
| 2005-06-19 | Mike Mussina | R | 37 | L 6-3 | vs CHN | 15 | 428 | W | 6.1 | 5 | 2 | 2 | 1 | 2 | 5 | 102 | 41 | 61 | 60% | 8-4 | 3.83 | 1.33 |
| 2005-06-20 | Sean Henn | L | 24 | W 4-5 | vs TBA | 2 | 2 | L | 4.2 | 4 | 4 | 3 | 0 | 7 | 1 | 95 | 52 | 43 | 45% | 0-2 | 10.29 | 2.86 |
| 2005-06-21 | Randy Johnson | L | 42 | L 20-11 | vs TBA | 15 | 494 | - | 3.0 | 8 | 7 | 7 | 3 | 1 | 3 | 60 | 20 | 40 | 67% | 7-5 | 4.02 | 1.19 |
| 2005-06-22 | Carl Pavano | R | 29 | W 3-5 | vs TBA | 16 | 165 | L | 6.2 | 6 | 5 | 5 | 2 | 1 | 7 | 102 | 35 | 67 | 66% | 4-6 | 4.69 | 1.46 |
| 2005-06-23 | Chien-Ming Wang | R | 25 | W 4-9 | vs TBA | 9 | 9 | L | 6.0 | 8 | 6 | 5 | 2 | 3 | 1 | 94 | 35 | 59 | 63% | 4-3 | 4.29 | 1.24 |
| 2005-06-24 | Mike Mussina | R | 37 | W 4-6 | vs NYN | 16 | 429 | L | 6.0 | 6 | 5 | 4 | 2 | 1 | 4 | 105 | 39 | 66 | 63% | 8-5 | 3.96 | 1.32 |
| 2005-06-25 | Sean Henn | L | 24 | W 3-10 | vs NYN | 3 | 3 | L | 4.1 | 7 | 6 | 6 | 3 | 2 | 2 | 86 | 33 | 53 | 62% | 0-3 | 11.45 | 2.64 |
| 2005-06-26 | Randy Johnson | L | 42 | L 5-4 | vs NYN | 16 | 495 | - | 6.2 | 6 | 4 | 1 | 0 | 1 | 5 | 112 | 28 | 84 | 75% | 7-5 | 3.85 | 1.18 |
| 2005-06-27 | Carl Pavano | R | 29 | W 6-4 | @ BAL | 17 | 166 | - | 6.0 | 9 | 4 | 4 | 1 | 1 | 0 | 92 | 39 | 53 | 58% | 4-6 | 4.77 | 1.47 |
| 2005-06-28 | Chien-Ming Wang | R | 25 | L 4-5 | @ BAL | 10 | 10 | - | 7.0 | 7 | 3 | 3 | 2 | 0 | 3 | 83 | 26 | 57 | 69% | 4-3 | 4.24 | 1.21 |
| 2005-07-01 | Randy Johnson | L | 42 | L 2-10 | @ DET | 17 | 496 | L | 5.0 | 9 | 7 | 7 | 2 | 1 | 2 | 84 | 30 | 54 | 64% | 7-6 | 4.23 | 1.22 |
| 2005-07-02 | Mike Mussina | R | 37 | W 8-4 | @ DET | 17 | 430 | - | 6.0 | 7 | 4 | 4 | 1 | 0 | 5 | 94 | 33 | 61 | 65% | 8-5 | 4.08 | 1.31 |
| 2005-07-03 | Chien-Ming Wang | R | 25 | W 1-0 | @ DET | 11 | 11 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 2 | 98 | 32 | 66 | 67% | 5-3 | 3.86 | 1.18 |
| 2005-07-04 | Tanyon Sturtze | R | 35 | L 13-8 | vs BAL | 1 | 84 | - | 3.2 | 3 | 4 | 4 | 1 | 3 | 1 | 81 | 38 | 43 | 53% | 2-1 | 3.91 | 1.09 |
| 2005-07-05 | Randy Johnson | L | 42 | L 12-3 | vs BAL | 18 | 497 | W | 7.0 | 7 | 2 | 2 | 1 | 0 | 8 | 93 | 23 | 70 | 75% | 8-6 | 4.13 | 1.20 |
| 2005-07-07 | Mike Mussina | R | 37 | L 7-2 | vs CLE | 18 | 431 | W | 7.0 | 6 | 2 | 2 | 1 | 3 | 5 | 102 | 40 | 62 | 61% | 9-5 | 3.98 | 1.31 |
| 2005-07-08 | Chien-Ming Wang | R | 25 | L 5-4 | vs CLE | 12 | 12 | W | 6.2 | 7 | 3 | 3 | 1 | 3 | 3 | 108 | 47 | 61 | 56% | 6-3 | 3.90 | 1.22 |
| 2005-07-09 | Darrell May | L | 33 | W 7-8 | vs CLE | 9 | 97 | L | 4.1 | 8 | 7 | 7 | 3 | 0 | 3 | 103 | 42 | 61 | 59% | 1-4 | 6.19 | 1.58 |
| 2005-07-10 | Randy Johnson | L | 42 | L 9-4 | vs CLE | 19 | 498 | W | 6.0 | 9 | 3 | 3 | 0 | 1 | 8 | 104 | 36 | 68 | 65% | 9-6 | 4.15 | 1.23 |
| 2005-07-14 | Mike Mussina | R | 37 | W 8-6 | @ BOS | 19 | 432 | - | 6.0 | 8 | 5 | 5 | 1 | 3 | 6 | 103 | 44 | 59 | 57% | 9-5 | 4.16 | 1.34 |
| 2005-07-15 | Tim Redding | R | 27 | L 1-17 | @ BOS | 7 | 79 | L | 1.0 | 4 | 6 | 6 | 0 | 4 | 2 | 41 | 25 | 16 | 39% | 0-6 | 10.45 | 1.97 |
| 2005-07-16 | Randy Johnson | L | 42 | W 7-4 | @ BOS | 20 | 499 | W | 6.1 | 8 | 4 | 4 | 2 | 3 | 10 | 114 | 48 | 66 | 58% | 10-6 | 4.23 | 1.25 |
| 2005-07-17 | Al Leiter | L | 40 | W 5-3 | @ BOS | 17 | 373 | W | 6.1 | 3 | 1 | 1 | 0 | 3 | 8 | 101 | 43 | 58 | 57% | 4-7 | 6.28 | 1.79 |
| 2005-07-18 | Kevin Brown | R | 40 | W 11-10 | @ TEX | 12 | 475 | - | 4.1 | 10 | 6 | 6 | 2 | 0 | 3 | 83 | 30 | 53 | 64% | 4-6 | 5.91 | 1.66 |
| 2005-07-19 | Mike Mussina | R | 37 | L 1-2 | @ TEX | 20 | 433 | - | 6.0 | 4 | 0 | 0 | 0 | 3 | 7 | 113 | 46 | 67 | 59% | 9-5 | 3.96 | 1.33 |
| 2005-07-20 | Aaron Small | R | 34 | W 8-4 | @ TEX | 1 | 4 | W | 5.1 | 5 | 3 | 3 | 1 | 4 | 3 | 92 | 41 | 51 | 55% | 1-0 | 5.40 | 1.80 |
| 2005-07-21 | Randy Johnson | L | 42 | L 5-6 | @ ANA | 21 | 500 | - | 6.0 | 4 | 2 | 2 | 0 | 2 | 4 | 87 | 27 | 60 | 69% | 10-6 | 4.18 | 1.24 |
| 2005-07-22 | Al Leiter | L | 40 | L 3-6 | @ ANA | 18 | 374 | L | 6.0 | 10 | 6 | 6 | 0 | 2 | 2 | 111 | 46 | 65 | 59% | 4-8 | 6.46 | 1.80 |
| 2005-07-23 | Kevin Brown | R | 40 | L 6-8 | @ ANA | 13 | 476 | L | 3.1 | 6 | 7 | 7 | 1 | 4 | 2 | 75 | 27 | 48 | 64% | 4-7 | 6.53 | 1.73 |
| 2005-07-24 | Mike Mussina | R | 37 | W 4-1 | @ ANA | 21 | 434 | W | 6.1 | 7 | 1 | 1 | 0 | 2 | 4 | 107 | 40 | 67 | 63% | 10-5 | 3.82 | 1.33 |
| 2005-07-26 | Randy Johnson | L | 42 | L 4-0 | vs MIN | 22 | 501 | W | 8.0 | 2 | 0 | 0 | 0 | 0 | 11 | 97 | 26 | 71 | 73% | 11-6 | 3.95 | 1.19 |
| 2005-07-27 | Al Leiter | L | 40 | W 3-7 | vs MIN | 19 | 375 | L | 5.0 | 7 | 1 | 1 | 0 | 5 | 2 | 115 | 53 | 62 | 54% | 4-9 | 6.22 | 1.84 |
| 2005-07-28 | Aaron Small | R | 34 | L 6-3 | vs MIN | 2 | 5 | W | 7.0 | 6 | 3 | 3 | 0 | 0 | 1 | 81 | 23 | 58 | 72% | 2-0 | 4.15 | 1.15 |
| 2005-07-29 | Mike Mussina | R | 37 | W 1-4 | vs ANA | 22 | 435 | L | 8.0 | 8 | 3 | 3 | 2 | 0 | 5 | 114 | 35 | 79 | 69% | 10-6 | 3.79 | 1.31 |
| 2005-07-30 | Shawn Chacon | R | 28 | L 8-7 | vs ANA | 13 | 84 | - | 6.0 | 4 | 1 | 0 | 0 | 3 | 4 | 102 | 48 | 54 | 53% | 1-7 | 3.76 | 1.42 |
| 2005-07-31 | Randy Johnson | L | 42 | L 8-7 | vs ANA | 23 | 502 | - | 7.1 | 6 | 6 | 6 | 2 | 2 | 7 | 109 | 35 | 74 | 68% | 11-6 | 4.12 | 1.19 |
| 2005-08-02 | Al Leiter | L | 40 | L 5-6 | @ CLE | 20 | 376 | L | 2.0 | 4 | 5 | 5 | 0 | 5 | 2 | 78 | 37 | 41 | 53% | 4-10 | 6.55 | 1.89 |
| 2005-08-03 | Mike Mussina | R | 37 | L 4-7 | @ CLE | 23 | 436 | L | 4.2 | 9 | 6 | 6 | 1 | 4 | 7 | 104 | 41 | 63 | 61% | 10-7 | 4.06 | 1.36 |
| 2005-08-04 | Shawn Chacon | R | 28 | W 4-3 | @ CLE | 14 | 85 | - | 6.0 | 8 | 2 | 2 | 0 | 2 | 4 | 104 | 42 | 62 | 60% | 1-7 | 3.71 | 1.44 |
| 2005-08-05 | Aaron Small | R | 34 | W 6-2 | @ TOR | 3 | 6 | W | 6.2 | 7 | 1 | 1 | 0 | 2 | 2 | 95 | 36 | 59 | 62% | 3-0 | 3.15 | 1.20 |
| 2005-08-06 | Randy Johnson | L | 42 | L 5-8 | @ TOR | 24 | 503 | L | 4.0 | 10 | 6 | 5 | 1 | 1 | 3 | 77 | 26 | 51 | 66% | 11-7 | 4.30 | 1.23 |
| 2005-08-07 | Al Leiter | L | 40 | W 6-2 | @ TOR | 21 | 377 | W | 5.2 | 4 | 0 | 0 | 0 | 4 | 2 | 102 | 51 | 51 | 50% | 5-10 | 6.17 | 1.86 |
| 2005-08-08 | Mike Mussina | R | 37 | L 3-2 | vs CHA | 24 | 437 | W | 6.0 | 8 | 2 | 2 | 0 | 0 | 7 | 122 | 41 | 81 | 66% | 11-7 | 4.02 | 1.36 |
| 2005-08-09 | Shawn Chacon | R | 28 | W 1-2 | vs CHA | 15 | 86 | L | 7.0 | 3 | 1 | 1 | 1 | 3 | 4 | 119 | 51 | 68 | 57% | 1-8 | 3.52 | 1.39 |
| 2005-08-10 | Aaron Small | R | 34 | W 1-2 | vs CHA | 4 | 7 | - | 7.0 | 4 | 1 | 1 | 0 | 2 | 7 | 106 | 39 | 67 | 63% | 3-0 | 2.67 | 1.11 |
| 2005-08-11 | Scott Proctor | R | 29 | L 9-8 | vs TEX | 1 | 1 | - | 5.0 | 3 | 3 | 3 | 2 | 0 | 3 | 76 | 26 | 50 | 66% | 0-0 | 5.14 | 1.21 |
| 2005-08-12 | Al Leiter | L | 40 | L 6-5 | vs TEX | 22 | 378 | W | 5.0 | 7 | 5 | 3 | 1 | 3 | 5 | 123 | 56 | 67 | 54% | 6-10 | 6.14 | 1.86 |
| 2005-08-13 | Mike Mussina | R | 37 | L 7-5 | vs TEX | 25 | 438 | - | 7.1 | 6 | 3 | 3 | 2 | 0 | 8 | 102 | 28 | 74 | 73% | 11-7 | 3.99 | 1.33 |
| 2005-08-14 | Shawn Chacon | R | 28 | L 10-3 | vs TEX | 16 | 87 | W | 5.0 | 7 | 3 | 3 | 1 | 0 | 5 | 87 | 35 | 52 | 60% | 2-8 | 3.58 | 1.39 |
| 2005-08-15 | Jaret Wright | R | 30 | W 5-2 | @ TBA | 5 | 133 | W | 6.1 | 4 | 2 | 2 | 1 | 1 | 2 | 81 | 32 | 49 | 60% | 3-2 | 7.62 | 1.92 |
| 2005-08-16 | Randy Johnson | L | 42 | L 3-4 | @ TBA | 25 | 504 | - | 7.0 | 5 | 2 | 2 | 1 | 2 | 7 | 95 | 29 | 66 | 69% | 11-7 | 4.23 | 1.22 |
| 2005-08-17 | Al Leiter | L | 40 | L 6-7 | @ TBA | 23 | 379 | - | 5.1 | 2 | 3 | 3 | 0 | 5 | 4 | 88 | 44 | 44 | 50% | 6-10 | 6.10 | 1.84 |
| 2005-08-19 | Mike Mussina | R | 37 | W 3-1 | @ CHA | 26 | 439 | W | 7.0 | 5 | 1 | 1 | 0 | 1 | 7 | 114 | 44 | 70 | 61% | 12-7 | 3.87 | 1.31 |
| 2005-08-20 | Shawn Chacon | R | 28 | W 5-0 | @ CHA | 17 | 88 | W | 8.0 | 4 | 0 | 0 | 0 | 3 | 5 | 127 | 49 | 78 | 61% | 3-8 | 3.31 | 1.35 |
| 2005-08-21 | Randy Johnson | L | 42 | L 2-6 | @ CHA | 26 | 505 | L | 8.0 | 10 | 6 | 6 | 4 | 0 | 8 | 122 | 38 | 84 | 69% | 11-8 | 4.34 | 1.22 |
| 2005-08-22 | Jaret Wright | R | 30 | L 7-0 | vs TOR | 6 | 134 | W | 7.0 | 4 | 0 | 0 | 0 | 3 | 5 | 99 | 39 | 60 | 61% | 4-2 | 6.00 | 1.73 |
| 2005-08-23 | Al Leiter | L | 40 | L 5-4 | vs TOR | 24 | 380 | - | 7.0 | 6 | 3 | 3 | 1 | 1 | 5 | 120 | 53 | 67 | 56% | 6-10 | 5.98 | 1.80 |
| 2005-08-24 | Mike Mussina | R | 37 | W 5-9 | vs TOR | 27 | 440 | L | 4.1 | 6 | 8 | 8 | 1 | 2 | 4 | 81 | 29 | 52 | 64% | 12-8 | 4.21 | 1.33 |
| 2005-08-25 | Shawn Chacon | R | 28 | L 6-2 | vs TOR | 18 | 89 | W | 7.0 | 6 | 2 | 2 | 0 | 4 | 6 | 119 | 53 | 66 | 55% | 4-8 | 3.27 | 1.35 |
| 2005-08-26 | Randy Johnson | L | 42 | L 5-1 | vs KCA | 27 | 506 | W | 8.0 | 4 | 1 | 1 | 0 | 0 | 6 | 103 | 26 | 77 | 75% | 12-8 | 4.20 | 1.19 |
| 2005-08-27 | Jaret Wright | R | 30 | L 8-7 | vs KCA | 7 | 135 | - | 5.0 | 7 | 5 | 5 | 0 | 2 | 5 | 108 | 40 | 68 | 63% | 4-2 | 6.39 | 1.74 |
| 2005-08-28 | Al Leiter | L | 40 | L 10-3 | vs KCA | 25 | 381 | W | 6.0 | 2 | 1 | 1 | 0 | 4 | 6 | 112 | 48 | 64 | 57% | 7-10 | 5.77 | 1.76 |
| 2005-08-29 | Mike Mussina | R | 37 | W 7-4 | @ SEA | 28 | 441 | - | 3.0 | 6 | 4 | 4 | 1 | 4 | 0 | 67 | 32 | 35 | 52% | 12-8 | 4.34 | 1.36 |
| 2005-08-30 | Shawn Chacon | R | 28 | L 3-8 | @ SEA | 19 | 90 | L | 6.0 | 8 | 8 | 8 | 1 | 4 | 3 | 113 | 52 | 61 | 54% | 4-9 | 3.71 | 1.39 |
| 2005-08-31 | Randy Johnson | L | 42 | W 2-0 | @ SEA | 28 | 507 | W | 7.0 | 3 | 0 | 0 | 0 | 2 | 7 | 121 | 38 | 83 | 69% | 13-8 | 4.05 | 1.17 |
| 2005-09-01 | Jaret Wright | R | 30 | L 1-5 | @ SEA | 8 | 136 | - | 5.1 | 3 | 1 | 1 | 0 | 2 | 0 | 85 | 36 | 49 | 58% | 4-2 | 5.86 | 1.65 |
| 2005-09-02 | Al Leiter | L | 40 | L 0-12 | @ OAK | 26 | 382 | L | 0.2 | 5 | 6 | 6 | 1 | 1 | 0 | 40 | 21 | 19 | 48% | 7-11 | 6.14 | 1.79 |
| 2005-09-03 | Aaron Small | R | 34 | W 7-0 | @ OAK | 5 | 8 | W | 9.0 | 5 | 0 | 0 | 0 | 2 | 3 | 111 | 35 | 76 | 68% | 6-0 | 2.40 | 1.16 |
| 2005-09-04 | Shawn Chacon | R | 28 | W 7-3 | @ OAK | 20 | 91 | W | 6.2 | 5 | 2 | 2 | 1 | 3 | 3 | 112 | 43 | 69 | 62% | 5-9 | 3.67 | 1.38 |
| 2005-09-06 | Randy Johnson | L | 42 | W 3-4 | vs TBA | 29 | 508 | - | 6.1 | 7 | 3 | 3 | 0 | 2 | 5 | 101 | 28 | 73 | 72% | 13-8 | 4.04 | 1.17 |
| 2005-09-07 | Jaret Wright | R | 30 | L 5-4 | vs TBA | 9 | 137 | - | 6.2 | 8 | 4 | 4 | 0 | 4 | 2 | 99 | 40 | 59 | 60% | 4-2 | 5.76 | 1.66 |
| 2005-09-08 | Chien-Ming Wang | R | 25 | W 4-7 | vs TBA | 13 | 13 | L | 5.0 | 8 | 3 | 3 | 0 | 2 | 2 | 79 | 30 | 49 | 62% | 6-4 | 3.99 | 1.26 |
| 2005-09-09 | Aaron Small | R | 34 | L 8-4 | vs BOS | 6 | 9 | W | 6.1 | 9 | 4 | 4 | 0 | 2 | 3 | 99 | 32 | 67 | 68% | 7-0 | 2.82 | 1.24 |
| 2005-09-10 | Shawn Chacon | R | 28 | W 2-9 | vs BOS | 21 | 92 | L | 3.0 | 6 | 5 | 5 | 2 | 3 | 1 | 77 | 35 | 42 | 55% | 5-10 | 3.94 | 1.42 |
| 2005-09-11 | Randy Johnson | L | 42 | L 1-0 | vs BOS | 30 | 509 | W | 7.0 | 1 | 0 | 0 | 0 | 2 | 8 | 100 | 34 | 66 | 66% | 14-8 | 3.90 | 1.15 |
| 2005-09-13 | Jaret Wright | R | 30 | W 17-3 | @ TBA | 10 | 138 | W | 7.0 | 5 | 3 | 2 | 0 | 4 | 4 | 106 | 43 | 63 | 59% | 5-2 | 5.37 | 1.61 |
| 2005-09-14 | Chien-Ming Wang | R | 25 | W 6-5 | @ TBA | 14 | 14 | W | 6.1 | 9 | 5 | 5 | 0 | 0 | 3 | 83 | 32 | 51 | 61% | 7-4 | 4.17 | 1.26 |
| 2005-09-15 | Aaron Small | R | 34 | W 9-5 | @ TBA | 7 | 10 | W | 6.2 | 7 | 5 | 5 | 1 | 0 | 4 | 87 | 29 | 58 | 67% | 8-0 | 3.26 | 1.21 |
| 2005-09-16 | Randy Johnson | L | 42 | W 11-10 | @ TOR | 31 | 510 | - | 1.2 | 2 | 3 | 3 | 1 | 2 | 2 | 49 | 23 | 26 | 53% | 14-8 | 4.01 | 1.16 |
| 2005-09-17 | Shawn Chacon | R | 28 | W 1-0 | @ TOR | 22 | 93 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 1 | 109 | 41 | 68 | 62% | 6-10 | 3.71 | 1.38 |
| 2005-09-18 | Jaret Wright | R | 30 | L 5-6 | @ TOR | 11 | 139 | L | 2.1 | 5 | 4 | 3 | 0 | 1 | 1 | 54 | 23 | 31 | 57% | 5-3 | 5.64 | 1.66 |
| 2005-09-19 | Chien-Ming Wang | R | 25 | L 3-2 | vs BAL | 15 | 15 | - | 8.0 | 7 | 2 | 2 | 0 | 1 | 4 | 96 | 30 | 66 | 69% | 7-4 | 4.02 | 1.24 |
| 2005-09-20 | Aaron Small | R | 34 | L 12-9 | vs BAL | 8 | 11 | W | 5.0 | 10 | 4 | 4 | 0 | 2 | 2 | 101 | 36 | 65 | 64% | 9-0 | 3.57 | 1.30 |
| 2005-09-21 | Randy Johnson | L | 42 | L 2-1 | vs BAL | 32 | 511 | W | 8.0 | 3 | 1 | 1 | 0 | 1 | 6 | 119 | 37 | 82 | 69% | 15-8 | 3.91 | 1.14 |
| 2005-09-22 | Mike Mussina | R | 37 | L 7-6 | vs BAL | 29 | 442 | W | 6.0 | 4 | 1 | 0 | 0 | 0 | 6 | 76 | 18 | 58 | 76% | 13-8 | 4.20 | 1.34 |
| 2005-09-23 | Shawn Chacon | R | 28 | L 5-0 | vs TOR | 23 | 94 | W | 8.0 | 3 | 0 | 0 | 0 | 1 | 3 | 111 | 38 | 73 | 66% | 7-10 | 3.50 | 1.33 |
| 2005-09-24 | Jaret Wright | R | 30 | W 4-7 | vs TOR | 12 | 140 | L | 1.0 | 6 | 7 | 3 | 0 | 1 | 1 | 37 | 15 | 22 | 59% | 5-4 | 6.00 | 1.75 |
| 2005-09-25 | Chien-Ming Wang | R | 25 | L 8-4 | vs TOR | 16 | 16 | W | 7.0 | 6 | 3 | 3 | 1 | 1 | 3 | 76 | 31 | 45 | 59% | 8-4 | 4.01 | 1.23 |
| 2005-09-26 | Randy Johnson | L | 42 | W 11-3 | @ BAL | 33 | 512 | W | 6.0 | 4 | 0 | 0 | 0 | 1 | 2 | 90 | 35 | 55 | 61% | 16-8 | 3.80 | 1.13 |
| 2005-09-27 | Mike Mussina | R | 37 | L 9-17 | @ BAL | 30 | 443 | - | 1.2 | 7 | 5 | 5 | 0 | 1 | 1 | 50 | 18 | 32 | 64% | 13-8 | 4.40 | 1.37 |
| 2005-09-28 | Shawn Chacon | R | 28 | W 2-1 | @ BAL | 24 | 95 | W | 6.2 | 4 | 1 | 1 | 1 | 3 | 1 | 98 | 38 | 60 | 61% | 8-10 | 3.40 | 1.31 |
| 2005-09-29 | Aaron Small | R | 34 | W 8-4 | @ BAL | 9 | 12 | W | 6.2 | 4 | 2 | 2 | 1 | 5 | 4 | 106 | 46 | 60 | 57% | 10-0 | 3.20 | 1.25 |
| 2005-09-30 | Chien-Ming Wang | R | 26 | L 3-5 | @ BOS | 17 | 17 | L | 6.2 | 4 | 5 | 3 | 1 | 6 | 4 | 114 | 56 | 58 | 51% | 8-5 | 4.03 | 1.25 |
| 2005-10-01 | Randy Johnson | L | 42 | W 8-4 | @ BOS | 34 | 513 | W | 7.1 | 5 | 3 | 3 | 2 | 3 | 8 | 129 | 43 | 86 | 67% | 17-8 | 3.78 | 1.12 |
| 2005-10-02 | Jaret Wright | R | 30 | L 1-10 | @ BOS | 13 | 141 | L | 3.1 | 3 | 3 | 3 | 1 | 5 | 1 | 74 | 38 | 36 | 49% | 5-5 | 6.05 | 1.77 |