| 2004-04-05 | @ KCA | 1 | L 7-9 | 0-1 | 4 | 41,575 | Mark Buehrle | Brian Anderson | D.J. Carrasco | Damaso Marte | | 7 | 9 | -2 |
| 2004-04-07 | @ KCA | 2 | W 4-3 | 1-1 | 3 | 16,134 | Esteban Loaiza | Darrell May | Esteban Loaiza | Darrell May | Billy Koch | 11 | 12 | -1 |
| 2004-04-08 | @ NYA | 3 | L 1-3 | 1-2 | 4 | 55,290 | Scott Schoeneweis | Javier Vazquez | Javier Vazquez | Scott Schoeneweis | Mariano Rivera | 12 | 15 | -3 |
| 2004-04-09 | @ NYA | 4 | W 9-3 | 2-2 | 2 | 45,965 | Jon Garland | Jose Contreras | Jon Garland | Jose Contreras | | 21 | 18 | 3 |
| 2004-04-10 | @ NYA | 5 | W 7-3 | 3-2 | 2 | 47,911 | Mark Buehrle | Jorge de Paula | Mark Buehrle | Jorge de Paula | | 28 | 21 | 7 |
| 2004-04-11 | @ NYA | 6 | L 4-5 | 3-3 | 3 | 37,484 | Dan Wright | Mike Mussina | Mike Mussina | Dan Wright | Mariano Rivera | 32 | 26 | 6 |
| 2004-04-13 | vs KCA | 7 | W 12-5 | 4-3 | 2 | 37,706 | Esteban Loaiza | Darrell May | Esteban Loaiza | Darrell May | | 44 | 31 | 13 |
| 2004-04-14 | vs KCA | 8 | W 10-9 | 5-3 | 2 | 11,765 | Jon Garland | Jeremy Affeldt | Jon Adkins | Curt Leskanic | | 54 | 40 | 14 |
| 2004-04-15 | vs KCA | 9 | W 6-5 | 6-3 | 1 | 15,150 | Mark Buehrle | Brian Anderson | Damaso Marte | D.J. Carrasco | | 60 | 45 | 15 |
| 2004-04-16 | @ TBA | 10 | L 0-3 | 6-4 | 1 | 12,108 | Dan Wright | Paul Abbott | Paul Abbott | Dan Wright | Danys Baez | 60 | 48 | 12 |
| 2004-04-17 | @ TBA | 11 | W 4-1 | 7-4 | 1 | 14,302 | Scott Schoeneweis | Victor Zambrano | Scott Schoeneweis | Victor Zambrano | Damaso Marte | 64 | 49 | 15 |
| 2004-04-18 | @ TBA | 12 | W 5-0 | 8-4 | 1 | 12,072 | Esteban Loaiza | Geremi Gonzalez | Esteban Loaiza | Geremi Gonzalez | | 69 | 49 | 20 |
| 2004-04-20 | vs NYA | 13 | L 8-11 | 8-5 | 2 | 32,034 | Mark Buehrle | Alex Graman | Paul Quantrill | Mark Buehrle | Mariano Rivera | 77 | 60 | 17 |
| 2004-04-21 | vs NYA | 14 | L 1-3 | 8-6 | 3 | 26,154 | Jon Garland | Javier Vazquez | Javier Vazquez | Jon Garland | Mariano Rivera | 78 | 63 | 15 |
| 2004-04-22 | vs NYA | 15 | W 4-3 | 9-6 | 2 | 34,030 | Scott Schoeneweis | Mike Mussina | Scott Schoeneweis | Mike Mussina | Damaso Marte | 82 | 66 | 16 |
| 2004-04-23 | vs TBA | 16 | W 3-2 | 10-6 | 2 | 12,049 | Esteban Loaiza | Victor Zambrano | Billy Koch | Danys Baez | | 85 | 68 | 17 |
| 2004-04-24 | vs TBA | 17 | L 1-4 | 10-7 | 3 | 17,062 | Dan Wright | Doug Waechter | Doug Waechter | Dan Wright | Danys Baez | 86 | 72 | 14 |
| 2004-04-25 | vs TBA | 18 | W 6-5 | 11-7 | 2 | 17,497 | Mark Buehrle | Geremi Gonzalez | Jon Adkins | Trever Miller | | 92 | 77 | 15 |
| 2004-04-27 | vs CLE | 19 | L 7-11 | 11-8 | 2 | 14,572 | Jon Garland | Jeff D'Amico | Rafael Betancourt | Jon Adkins | | 99 | 88 | 11 |
| 2004-04-28 | vs CLE | 20 | W 9-8 | 12-8 | 2 | 12,189 | Scott Schoeneweis | Jason Davis | Michael Jackson | Rafael Betancourt | | 108 | 96 | 12 |
| 2004-04-29 | vs TOR | 21 | W 6-4 | 13-8 | 2 | 11,210 | Esteban Loaiza | Pat Hentgen | Esteban Loaiza | Micheal Nakamura | Billy Koch | 114 | 100 | 14 |
| 2004-05-01 | vs TOR | 22 | W 4-3 | 14-9 | 2 | 0 | Mark Buehrle | Roy Halladay | Shingo Takatsu | Justin Speier | | 118 | 103 | 15 |
| 2004-05-01 | vs TOR | 23 | L 6-10 | 14-9 | 2 | 22,072 | Dan Wright | Ted Lilly | Ted Lilly | Dan Wright | | 124 | 113 | 11 |
| 2004-05-02 | vs TOR | 24 | W 3-2 | 15-9 | 1 | 15,550 | Jon Garland | Miguel Batista | Jon Garland | Miguel Batista | Billy Koch | 127 | 115 | 12 |
| 2004-05-03 | @ BAL | 25 | W 5-4 | 16-9 | 1 | 18,849 | Scott Schoeneweis | Kurt Ainsworth | Scott Schoeneweis | Mike DeJean | Billy Koch | 132 | 119 | 13 |
| 2004-05-04 | @ BAL | 26 | L 3-10 | 16-10 | 1 | 21,488 | Esteban Loaiza | Eric DuBose | Rodrigo Lopez | Esteban Loaiza | | 135 | 129 | 6 |
| 2004-05-05 | @ BAL | 27 | W 6-5 | 17-10 | 1 | 20,978 | Mark Buehrle | Sidney Ponson | Shingo Takatsu | B.J. Ryan | Billy Koch | 141 | 134 | 7 |
| 2004-05-07 | @ TOR | 28 | L 4-5 | 17-11 | 1 | 15,661 | Jon Garland | Ted Lilly | Terry Adams | Cliff Politte | | 145 | 139 | 6 |
| 2004-05-08 | @ TOR | 29 | L 2-4 | 17-12 | 1 | 18,368 | Scott Schoeneweis | Miguel Batista | Jason Frasor | Neal Cotts | Terry Adams | 147 | 143 | 4 |
| 2004-05-09 | @ TOR | 30 | L 2-5 | 17-13 | 1 | 17,546 | Esteban Loaiza | Justin Miller | Justin Miller | Esteban Loaiza | Kerry Ligtenberg | 149 | 148 | 1 |
| 2004-05-11 | vs BAL | 31 | W 15-0 | 18-13 | 1 | 20,400 | Mark Buehrle | Sidney Ponson | Mark Buehrle | Sidney Ponson | | 164 | 148 | 16 |
| 2004-05-13 | vs BAL | 32 | L 0-1 | 19-14 | 2 | 0 | Jon Garland | Daniel Cabrera | Daniel Cabrera | Jon Garland | Jorge Julio | 164 | 149 | 15 |
| 2004-05-13 | vs BAL | 33 | W 6-5 | 19-14 | 2 | 18,324 | Felix Diaz | Erik Bedard | Michael Jackson | Erik Bedard | Billy Koch | 170 | 154 | 16 |
| 2004-05-14 | vs MIN | 34 | L 2-3 | 19-15 | 2 | 15,962 | Scott Schoeneweis | Kyle Lohse | Juan Rincon | Damaso Marte | Joe Nathan | 172 | 157 | 15 |
| 2004-05-15 | vs MIN | 35 | L 1-4 | 19-16 | 2 | 32,360 | Esteban Loaiza | Seth Greisinger | Seth Greisinger | Esteban Loaiza | Joe Nathan | 173 | 161 | 12 |
| 2004-05-16 | vs MIN | 36 | W 11-0 | 20-16 | 2 | 26,348 | Mark Buehrle | Carlos Silva | Mark Buehrle | Carlos Silva | | 184 | 161 | 23 |
| 2004-05-17 | @ CLE | 37 | L 2-7 | 20-17 | 2 | 15,617 | Felix Diaz | Cliff Lee | Cliff Lee | Felix Diaz | | 186 | 168 | 18 |
| 2004-05-18 | @ CLE | 38 | W 4-2 | 21-17 | 2 | 15,298 | Jon Garland | Chad Durbin | Jon Garland | Chad Durbin | Billy Koch | 190 | 170 | 20 |
| 2004-05-19 | @ CLE | 39 | W 15-3 | 22-17 | 2 | 17,205 | Scott Schoeneweis | Jason Davis | Scott Schoeneweis | Jason Davis | | 205 | 173 | 32 |
| 2004-05-20 | @ MIN | 40 | W 10-3 | 23-17 | 2 | 17,640 | Esteban Loaiza | Seth Greisinger | Esteban Loaiza | Seth Greisinger | | 215 | 176 | 39 |
| 2004-05-21 | @ MIN | 41 | W 8-2 | 24-17 | 1 | 30,116 | Mark Buehrle | Carlos Silva | Mark Buehrle | Carlos Silva | | 223 | 178 | 45 |
| 2004-05-22 | @ MIN | 42 | L 1-9 | 24-18 | 2 | 27,413 | Neal Cotts | Brad Radke | Brad Radke | Neal Cotts | | 224 | 187 | 37 |
| 2004-05-23 | @ MIN | 43 | W 17-7 | 25-18 | 1 | 22,859 | Jon Garland | Johan Santana | Jon Garland | Johan Santana | | 241 | 194 | 47 |
| 2004-05-25 | vs TEX | 44 | L 4-7 | 25-19 | 1 | 22,359 | Scott Schoeneweis | Kenny Rogers | Kenny Rogers | Scott Schoeneweis | Francisco Cordero | 245 | 201 | 44 |
| 2004-05-26 | vs TEX | 45 | W 4-0 | 26-19 | 1 | 18,185 | Esteban Loaiza | Joaquin Benoit | Esteban Loaiza | Joaquin Benoit | | 249 | 201 | 48 |
| 2004-05-27 | vs TEX | 46 | W 9-0 | 27-19 | 1 | 14,428 | Mark Buehrle | Ryan Drese | Mark Buehrle | Ryan Drese | | 258 | 201 | 57 |
| 2004-05-28 | vs ANA | 47 | W 4-3 | 28-19 | 1 | 21,163 | Jon Garland | Kelvim Escobar | Shingo Takatsu | Ramon Ortiz | | 262 | 204 | 58 |
| 2004-05-29 | vs ANA | 48 | L 1-5 | 28-20 | 1 | 25,050 | Jon Rauch | Aaron Sele | Aaron Sele | Jon Rauch | | 263 | 209 | 54 |
| 2004-05-30 | vs ANA | 49 | W 11-2 | 29-20 | 1 | 19,859 | Scott Schoeneweis | John Lackey | Scott Schoeneweis | John Lackey | | 274 | 211 | 63 |
| 2004-06-01 | @ OAK | 50 | L 4-6 | 29-21 | 1 | 14,344 | Esteban Loaiza | Mark Redman | Justin Duchscherer | Neal Cotts | | 278 | 217 | 61 |
| 2004-06-02 | @ OAK | 51 | L 2-3 | 29-22 | 1 | 33,111 | Mark Buehrle | Mark Mulder | Arthur Rhodes | Jon Adkins | | 280 | 220 | 60 |
| 2004-06-04 | @ SEA | 52 | W 4-2 | 30-22 | 1 | 36,340 | Jon Garland | Freddy Garcia | Jon Garland | Freddy Garcia | Billy Koch | 284 | 222 | 62 |
| 2004-06-05 | @ SEA | 53 | L 2-4 | 30-23 | 1 | 40,050 | Scott Schoeneweis | Ryan Franklin | Ryan Franklin | Scott Schoeneweis | Eddie Guardado | 286 | 226 | 60 |
| 2004-06-06 | @ SEA | 54 | L 4-5 | 30-24 | 1 | 36,462 | Esteban Loaiza | Jamie Moyer | Shigetoshi Hasegawa | Billy Koch | | 290 | 231 | 59 |
| 2004-06-08 | vs PHI | 55 | W 14-11 | 31-24 | 1 | 33,114 | Mark Buehrle | Ryan Madson | Mark Buehrle | Amaury Telemaco | Cliff Politte | 304 | 242 | 62 |
| 2004-06-09 | vs PHI | 56 | L 10-13 | 31-25 | 1 | 17,570 | Jon Garland | Eric Milton | Eric Milton | Jon Garland | | 314 | 255 | 59 |
| 2004-06-11 | vs ATL | 57 | L 4-6 | 31-26 | 2 | 23,217 | Scott Schoeneweis | Jaret Wright | Jaret Wright | Scott Schoeneweis | | 318 | 261 | 57 |
| 2004-06-12 | vs ATL | 58 | W 10-8 | 32-26 | 2 | 34,719 | Esteban Loaiza | John Thomson | Esteban Loaiza | John Thomson | Shingo Takatsu | 328 | 269 | 59 |
| 2004-06-13 | vs ATL | 59 | W 10-3 | 33-26 | 1 | 32,589 | Mark Buehrle | Travis Smith | Mark Buehrle | Travis Smith | | 338 | 272 | 66 |
| 2004-06-15 | @ FLO | 60 | W 7-5 | 34-26 | 1 | 15,345 | Jon Garland | A.J. Burnett | Damaso Marte | Toby Borland | Shingo Takatsu | 345 | 277 | 68 |
| 2004-06-16 | @ FLO | 61 | L 0-4 | 34-27 | 2 | 14,310 | Scott Schoeneweis | Carl Pavano | Carl Pavano | Scott Schoeneweis | | 345 | 281 | 64 |
| 2004-06-17 | @ FLO | 62 | L 1-2 | 34-28 | 2 | 17,857 | Esteban Loaiza | Josh Beckett | Armando Benitez | Cliff Politte | | 346 | 283 | 63 |
| 2004-06-18 | @ MON | 63 | W 11-7 | 35-28 | 2 | 4,576 | Mark Buehrle | Claudio Vargas | Neal Cotts | Luis Ayala | Damaso Marte | 357 | 290 | 67 |
| 2004-06-19 | @ MON | 64 | L 14-17 | 35-29 | 2 | 18,414 | Arnie Munoz | Tony Armas | Jeremy Fikac | Arnie Munoz | Chad Cordero | 371 | 307 | 64 |
| 2004-06-20 | @ MON | 65 | L 2-4 | 35-30 | 2 | 6,546 | Jon Garland | Zach Day | Chad Cordero | Jon Garland | | 373 | 311 | 62 |
| 2004-06-21 | vs CLE | 66 | L 1-5 | 35-31 | 2 | 29,722 | Scott Schoeneweis | CC Sabathia | CC Sabathia | Scott Schoeneweis | | 374 | 316 | 58 |
| 2004-06-22 | vs CLE | 67 | W 11-9 | 36-31 | 2 | 27,922 | Esteban Loaiza | Scott Elarton | Shingo Takatsu | Jose Jimenez | | 385 | 325 | 60 |
| 2004-06-23 | vs CLE | 68 | L 5-9 | 36-32 | 2 | 21,654 | Mark Buehrle | Cliff Lee | Cliff Lee | Mark Buehrle | | 390 | 334 | 56 |
| 2004-06-24 | vs CLE | 69 | W 7-1 | 37-32 | 2 | 20,744 | Jon Rauch | Jake Westbrook | Jon Rauch | Jake Westbrook | | 397 | 335 | 62 |
| 2004-06-25 | vs CHN | 70 | L 4-7 | 37-33 | 2 | 39,596 | Jon Garland | Mark Prior | Mark Prior | Jon Garland | LaTroy Hawkins | 401 | 342 | 59 |
| 2004-06-26 | vs CHN | 71 | W 6-3 | 38-33 | 2 | 39,553 | Felix Diaz | Carlos Zambrano | Felix Diaz | Carlos Zambrano | Shingo Takatsu | 407 | 345 | 62 |
| 2004-06-27 | vs CHN | 72 | W 9-4 | 39-33 | 2 | 38,526 | Esteban Loaiza | Greg Maddux | Esteban Loaiza | Greg Maddux | | 416 | 349 | 67 |
| 2004-06-29 | @ MIN | 73 | W 6-2 | 40-33 | 1 | 24,704 | Mark Buehrle | Carlos Silva | Mark Buehrle | Carlos Silva | | 422 | 351 | 71 |
| 2004-06-30 | @ MIN | 74 | W 9-6 | 41-33 | 1 | 25,433 | Freddy Garcia | Brad Radke | Freddy Garcia | Brad Radke | | 431 | 357 | 74 |
| 2004-07-01 | @ MIN | 75 | W 2-1 | 42-33 | 1 | 21,127 | Jon Garland | Johan Santana | Jon Garland | Johan Santana | Damaso Marte | 433 | 358 | 75 |
| 2004-07-02 | @ CHN | 76 | L 2-6 | 42-34 | 1 | 39,625 | Esteban Loaiza | Carlos Zambrano | Carlos Zambrano | Esteban Loaiza | | 435 | 364 | 71 |
| 2004-07-03 | @ CHN | 77 | L 2-4 | 42-35 | 1 | 39,528 | Felix Diaz | Greg Maddux | Greg Maddux | Felix Diaz | Michael Wuertz | 437 | 368 | 69 |
| 2004-07-04 | @ CHN | 78 | L 1-2 | 42-36 | 1 | 38,596 | Mark Buehrle | Glendon Rusch | LaTroy Hawkins | Shingo Takatsu | | 438 | 370 | 68 |
| 2004-07-06 | vs ANA | 79 | L 2-6 | 42-37 | 2 | 26,209 | Freddy Garcia | John Lackey | John Lackey | Freddy Garcia | | 440 | 376 | 64 |
| 2004-07-07 | vs ANA | 80 | L 0-12 | 42-38 | 2 | 21,378 | Scott Schoeneweis | Jarrod Washburn | Jarrod Washburn | Scott Schoeneweis | | 440 | 388 | 52 |
| 2004-07-08 | vs ANA | 81 | W 9-8 | 43-38 | 2 | 27,845 | Esteban Loaiza | Aaron Sele | Damaso Marte | Brendan Donnelly | | 449 | 396 | 53 |
| 2004-07-09 | vs SEA | 82 | W 6-2 | 44-38 | 2 | 21,713 | Jon Garland | Joel Pineiro | Jon Garland | Joel Pineiro | | 455 | 398 | 57 |
| 2004-07-10 | vs SEA | 83 | W 3-2 | 45-38 | 2 | 37,405 | Mark Buehrle | Matt Thornton | Mark Buehrle | Matt Thornton | Shingo Takatsu | 458 | 400 | 58 |
| 2004-07-11 | vs SEA | 84 | W 4-3 | 46-38 | 1 | 31,305 | Freddy Garcia | Jamie Moyer | Freddy Garcia | Jamie Moyer | Shingo Takatsu | 462 | 403 | 59 |
| 2004-07-15 | @ OAK | 85 | L 2-4 | 46-39 | 1 | 15,414 | Jon Garland | Rich Harden | Rich Harden | Jon Garland | Octavio Dotel | 464 | 407 | 57 |
| 2004-07-16 | @ OAK | 86 | L 1-5 | 46-40 | 1 | 40,891 | Mark Buehrle | Barry Zito | Barry Zito | Mark Buehrle | Octavio Dotel | 465 | 412 | 53 |
| 2004-07-17 | @ OAK | 87 | W 5-2 | 47-40 | 1 | 26,285 | Freddy Garcia | Mark Redman | Freddy Garcia | Mark Redman | Shingo Takatsu | 470 | 414 | 56 |
| 2004-07-18 | @ OAK | 88 | L 3-5 | 47-41 | 1 | 33,274 | Esteban Loaiza | Mark Mulder | Mark Mulder | Esteban Loaiza | Octavio Dotel | 473 | 419 | 54 |
| 2004-07-19 | @ TEX | 89 | W 12-6 | 48-41 | 1 | 28,805 | Scott Schoeneweis | Joaquin Benoit | Scott Schoeneweis | Joaquin Benoit | | 485 | 425 | 60 |
| 2004-07-20 | @ TEX | 90 | L 4-6 | 48-42 | 2 | 27,308 | Jon Garland | John Wasdin | Carlos Almanzar | Damaso Marte | Francisco Cordero | 489 | 431 | 58 |
| 2004-07-21 | @ CLE | 91 | W 14-0 | 49-42 | 2 | 21,922 | Mark Buehrle | Cliff Lee | Mark Buehrle | Cliff Lee | | 503 | 431 | 72 |
| 2004-07-22 | @ CLE | 92 | W 3-0 | 50-42 | 2 | 23,168 | Freddy Garcia | CC Sabathia | Freddy Garcia | CC Sabathia | Shingo Takatsu | 506 | 431 | 75 |
| 2004-07-23 | vs DET | 93 | W 6-4 | 51-42 | 2 | 32,930 | Esteban Loaiza | Nate Robertson | Esteban Loaiza | Nate Robertson | Shingo Takatsu | 512 | 435 | 77 |
| 2004-07-24 | vs DET | 94 | W 7-6 | 52-42 | 1 | 38,055 | Scott Schoeneweis | Jason Johnson | Damaso Marte | Ugueth Urbina | | 519 | 441 | 78 |
| 2004-07-25 | vs DET | 95 | L 2-9 | 52-43 | 2 | 26,716 | Jon Garland | Jeremy Bonderman | Wil Ledezma | Jon Garland | | 521 | 450 | 71 |
| 2004-07-26 | vs MIN | 96 | L 2-6 | 52-44 | 2 | 38,362 | Mark Buehrle | Brad Radke | Brad Radke | Mark Buehrle | | 523 | 456 | 67 |
| 2004-07-27 | vs MIN | 97 | L 3-7 | 52-45 | 2 | 37,528 | Freddy Garcia | Johan Santana | Johan Santana | Freddy Garcia | | 526 | 463 | 63 |
| 2004-07-28 | vs MIN | 98 | L 4-5 | 52-46 | 2 | 32,605 | Esteban Loaiza | Carlos Silva | Terry Mulholland | Shingo Takatsu | Joe Nathan | 530 | 468 | 62 |
| 2004-07-29 | @ DET | 99 | L 2-3 | 52-47 | 2 | 26,110 | Scott Schoeneweis | Jason Johnson | Jason Johnson | Scott Schoeneweis | Ugueth Urbina | 532 | 471 | 61 |
| 2004-07-30 | @ DET | 100 | L 4-5 | 52-48 | 2 | 34,732 | Jon Garland | Wil Ledezma | Esteban Yan | Damaso Marte | Ugueth Urbina | 536 | 476 | 60 |
| 2004-07-31 | @ DET | 101 | L 2-3 | 52-49 | 2 | 40,471 | Mark Buehrle | Mike Maroth | Ugueth Urbina | Cliff Politte | | 538 | 479 | 59 |
| 2004-08-01 | @ DET | 102 | W 6-4 | 53-49 | 2 | 34,279 | Freddy Garcia | Jeremy Bonderman | Freddy Garcia | Jeremy Bonderman | Shingo Takatsu | 544 | 483 | 61 |
| 2004-08-03 | @ KCA | 103 | W 12-4 | 54-49 | 2 | 13,981 | Jose Contreras | Mike Wood | Jose Contreras | Mike Wood | | 556 | 487 | 69 |
| 2004-08-04 | @ KCA | 104 | L 0-11 | 54-50 | 2 | 16,194 | Scott Schoeneweis | Brian Anderson | Brian Anderson | Scott Schoeneweis | | 556 | 498 | 58 |
| 2004-08-05 | @ KCA | 105 | L 4-6 | 54-51 | 2 | 15,863 | Jon Garland | Zack Greinke | Zack Greinke | Jon Garland | Nate Field | 560 | 504 | 56 |
| 2004-08-06 | vs CLE | 106 | L 2-3 | 54-52 | 2 | 23,811 | Mark Buehrle | CC Sabathia | CC Sabathia | Mark Buehrle | Bob Wickman | 562 | 507 | 55 |
| 2004-08-07 | vs CLE | 107 | L 5-6 | 54-53 | 3 | 32,790 | Freddy Garcia | Cliff Lee | Matt Miller | Shingo Takatsu | Bob Wickman | 567 | 513 | 54 |
| 2004-08-08 | vs CLE | 108 | W 3-2 | 55-53 | 2 | 25,897 | Jose Contreras | Scott Elarton | Shingo Takatsu | Rafael Betancourt | | 570 | 515 | 55 |
| 2004-08-09 | vs CLE | 109 | L 11-13 | 55-54 | 3 | 31,116 | Felix Diaz | Jake Westbrook | Jake Westbrook | Felix Diaz | | 581 | 528 | 53 |
| 2004-08-10 | vs KCA | 110 | W 9-3 | 56-54 | 3 | 20,506 | Jon Garland | Zack Greinke | Jon Garland | Zack Greinke | | 590 | 531 | 59 |
| 2004-08-11 | vs KCA | 111 | L 2-4 | 56-55 | 3 | 18,396 | Mark Buehrle | Darrell May | Darrell May | Mark Buehrle | Jaime Cerda | 592 | 535 | 57 |
| 2004-08-12 | vs KCA | 112 | W 3-2 | 57-55 | 3 | 22,399 | Freddy Garcia | Jimmy Serrano | Freddy Garcia | Jimmy Serrano | Shingo Takatsu | 595 | 537 | 58 |
| 2004-08-13 | @ BOS | 113 | W 8-7 | 58-55 | 3 | 35,028 | Jose Contreras | Tim Wakefield | Jose Contreras | Tim Wakefield | Shingo Takatsu | 603 | 544 | 59 |
| 2004-08-14 | @ BOS | 114 | L 3-4 | 58-56 | 3 | 35,012 | Jon Garland | Curt Schilling | Curt Schilling | Jon Adkins | Keith Foulke | 606 | 548 | 58 |
| 2004-08-15 | @ BOS | 115 | W 5-4 | 59-56 | 3 | 34,405 | Mark Buehrle | Bronson Arroyo | Mark Buehrle | Bronson Arroyo | Shingo Takatsu | 611 | 552 | 59 |
| 2004-08-17 | vs DET | 116 | L 8-11 | 59-57 | 3 | 19,856 | Freddy Garcia | Mike Maroth | Mike Maroth | Freddy Garcia | Ugueth Urbina | 619 | 563 | 56 |
| 2004-08-18 | vs DET | 117 | W 9-2 | 60-57 | 3 | 21,381 | Jose Contreras | Jeremy Bonderman | Jose Contreras | Jeremy Bonderman | | 628 | 565 | 63 |
| 2004-08-19 | vs DET | 118 | L 4-8 | 60-58 | 3 | 24,554 | Jon Garland | Wil Ledezma | Wil Ledezma | Jon Garland | Gary Knotts | 632 | 573 | 59 |
| 2004-08-20 | vs BOS | 119 | L 1-10 | 60-59 | 3 | 38,720 | Mark Buehrle | Curt Schilling | Curt Schilling | Mark Buehrle | | 633 | 583 | 50 |
| 2004-08-21 | vs BOS | 120 | L 7-10 | 60-60 | 3 | 37,303 | Josh Stewart | Bronson Arroyo | Bronson Arroyo | Josh Stewart | Keith Foulke | 640 | 593 | 47 |
| 2004-08-22 | vs BOS | 121 | L 5-6 | 60-61 | 3 | 34,355 | Freddy Garcia | Derek Lowe | Curt Leskanic | Damaso Marte | Keith Foulke | 645 | 599 | 46 |
| 2004-08-23 | @ DET | 122 | L 0-7 | 60-62 | 3 | 25,220 | Jose Contreras | Jeremy Bonderman | Jeremy Bonderman | Jose Contreras | | 645 | 606 | 39 |
| 2004-08-24 | @ DET | 123 | W 9-5 | 61-62 | 3 | 24,584 | Jon Garland | Wil Ledezma | Jon Garland | Wil Ledezma | | 654 | 611 | 43 |
| 2004-08-25 | @ DET | 124 | L 4-5 | 61-63 | 3 | 23,254 | Mark Buehrle | Nate Robertson | Nate Robertson | Mark Buehrle | | 658 | 616 | 42 |
| 2004-08-26 | @ CLE | 125 | W 14-9 | 62-63 | 3 | 30,049 | Josh Stewart | Chad Durbin | Neal Cotts | Chad Durbin | | 672 | 625 | 47 |
| 2004-08-27 | @ CLE | 126 | L 3-6 | 62-64 | 3 | 30,527 | Jason Grilli | CC Sabathia | CC Sabathia | Jason Grilli | Bob Wickman | 675 | 631 | 44 |
| 2004-08-28 | @ CLE | 127 | W 5-3 | 63-64 | 3 | 37,374 | Jose Contreras | Cliff Lee | Jose Contreras | Cliff Lee | Shingo Takatsu | 680 | 634 | 46 |
| 2004-08-29 | @ CLE | 128 | L 0-9 | 63-65 | 3 | 32,834 | Jon Garland | Scott Elarton | Scott Elarton | Jon Garland | | 680 | 643 | 37 |
| 2004-08-30 | vs PHI | 129 | W 9-8 | 64-65 | 3 | 5,747 | Mark Buehrle | Brett Myers | Mark Buehrle | Roberto Hernandez | Shingo Takatsu | 689 | 651 | 38 |
| 2004-08-31 | vs OAK | 130 | L 2-7 | 64-66 | 3 | 18,841 | Felix Diaz | Rich Harden | Rich Harden | Felix Diaz | | 691 | 658 | 33 |
| 2004-09-01 | vs OAK | 131 | W 5-4 | 65-66 | 3 | 21,564 | Jason Grilli | Barry Zito | Shingo Takatsu | Justin Duchscherer | | 696 | 662 | 34 |
| 2004-09-02 | vs OAK | 132 | L 2-4 | 65-67 | 3 | 17,579 | Jose Contreras | Mark Redman | Mark Redman | Jose Contreras | Octavio Dotel | 698 | 666 | 32 |
| 2004-09-03 | vs SEA | 133 | W 7-5 | 66-67 | 2 | 21,716 | Jon Garland | Bobby Madritsch | Jon Garland | Bobby Madritsch | Shingo Takatsu | 705 | 671 | 34 |
| 2004-09-04 | vs SEA | 134 | W 8-7 | 67-67 | 2 | 24,191 | Mark Buehrle | Ryan Franklin | Mark Buehrle | Ryan Franklin | Shingo Takatsu | 713 | 678 | 35 |
| 2004-09-05 | vs SEA | 135 | W 6-2 | 68-67 | 2 | 30,409 | Felix Diaz | Jamie Moyer | Felix Diaz | Jamie Moyer | Damaso Marte | 719 | 680 | 39 |
| 2004-09-06 | @ TEX | 136 | W 7-4 | 69-67 | 2 | 31,251 | Jason Grilli | Chan Ho Park | Jason Grilli | Chan Ho Park | | 726 | 684 | 42 |
| 2004-09-07 | @ TEX | 137 | L 3-10 | 69-68 | 2 | 20,004 | Jose Contreras | Kenny Rogers | Kenny Rogers | Jose Contreras | | 729 | 694 | 35 |
| 2004-09-08 | @ TEX | 138 | W 5-2 | 70-68 | 2 | 21,836 | Freddy Garcia | John Wasdin | Freddy Garcia | John Wasdin | Shingo Takatsu | 734 | 696 | 38 |
| 2004-09-09 | @ TEX | 139 | W 7-3 | 71-68 | 2 | 19,384 | Mark Buehrle | Chris Young | Mark Buehrle | Chris Young | | 741 | 699 | 42 |
| 2004-09-10 | @ ANA | 140 | L 5-7 | 71-69 | 2 | 42,431 | Jon Garland | John Lackey | Francisco Rodriguez | Jeff Bajenaru | Troy Percival | 746 | 706 | 40 |
| 2004-09-11 | @ ANA | 141 | W 13-6 | 72-69 | 2 | 42,568 | Jason Grilli | Aaron Sele | Jason Grilli | Aaron Sele | | 759 | 712 | 47 |
| 2004-09-12 | @ ANA | 142 | L 0-11 | 72-70 | 2 | 41,932 | Jose Contreras | Bartolo Colon | Bartolo Colon | Jose Contreras | | 759 | 723 | 36 |
| 2004-09-14 | @ MIN | 143 | L 2-10 | 72-71 | 2 | 22,145 | Freddy Garcia | Johan Santana | Johan Santana | Freddy Garcia | | 761 | 733 | 28 |
| 2004-09-15 | @ MIN | 144 | L 1-6 | 72-72 | 2 | 20,612 | Mark Buehrle | Carlos Silva | Carlos Silva | Mark Buehrle | | 762 | 739 | 23 |
| 2004-09-16 | @ MIN | 145 | L 1-10 | 72-73 | 2 | 20,052 | Jon Garland | Kyle Lohse | Kyle Lohse | Jon Garland | | 763 | 749 | 14 |
| 2004-09-17 | vs DET | 146 | L 10-11 | 72-74 | 2 | 23,132 | Jason Grilli | Nate Robertson | Esteban Yan | Shingo Takatsu | John Ennis | 773 | 760 | 13 |
| 2004-09-18 | vs DET | 147 | W 9-8 | 73-74 | 2 | 23,533 | Jose Contreras | Jason Johnson | Damaso Marte | Al Levine | | 782 | 768 | 14 |
| 2004-09-19 | vs DET | 148 | W 6-1 | 74-74 | 2 | 19,269 | Freddy Garcia | Jeremy Bonderman | Freddy Garcia | Jeremy Bonderman | | 788 | 769 | 19 |
| 2004-09-20 | vs MIN | 149 | L 2-8 | 74-75 | 2 | 21,991 | Mark Buehrle | Carlos Silva | Carlos Silva | Mark Buehrle | | 790 | 777 | 13 |
| 2004-09-21 | vs MIN | 150 | W 8-6 | 75-75 | 2 | 14,771 | Jon Garland | Kyle Lohse | Neal Cotts | J.C. Romero | Shingo Takatsu | 798 | 783 | 15 |
| 2004-09-22 | vs MIN | 151 | W 7-6 | 76-75 | 2 | 22,396 | Jason Grilli | Terry Mulholland | Neal Cotts | Joe Roa | | 805 | 789 | 16 |
| 2004-09-23 | vs KCA | 152 | W 7-6 | 77-75 | 2 | 16,015 | Jose Contreras | Mike Wood | Damaso Marte | Jeremy Affeldt | | 812 | 795 | 17 |
| 2004-09-24 | vs KCA | 153 | L 6-8 | 77-76 | 2 | 14,270 | Freddy Garcia | Jimmy Gobble | Jimmy Gobble | Felix Diaz | | 818 | 803 | 15 |
| 2004-09-25 | vs KCA | 154 | W 5-1 | 78-76 | 2 | 20,625 | Mark Buehrle | Denny Bautista | Mark Buehrle | Denny Bautista | | 823 | 804 | 19 |
| 2004-09-26 | vs KCA | 155 | W 5-1 | 79-76 | 2 | 18,949 | Jon Garland | Brian Anderson | Jon Garland | Brian Anderson | Damaso Marte | 828 | 805 | 23 |
| 2004-09-27 | @ DET | 156 | L 2-4 | 79-77 | 2 | 12,495 | Jason Grilli | Gary Knotts | Gary Knotts | Jason Grilli | Esteban Yan | 830 | 809 | 21 |
| 2004-09-28 | @ DET | 157 | L 4-6 | 79-78 | 2 | 13,860 | Jose Contreras | Nate Robertson | Franklyn German | Neal Cotts | Esteban Yan | 834 | 815 | 19 |
| 2004-09-29 | @ DET | 158 | W 11-2 | 80-78 | 2 | 8,944 | Freddy Garcia | Jason Johnson | Freddy Garcia | Jason Johnson | | 845 | 817 | 28 |
| 2004-09-30 | @ KCA | 159 | W 9-2 | 81-78 | 2 | 11,507 | Mark Buehrle | Chris George | Mark Buehrle | Shawn Camp | | 854 | 819 | 35 |
| 2004-10-01 | @ KCA | 160 | W 4-2 | 82-78 | 2 | 14,766 | Jon Garland | Denny Bautista | Jon Garland | Jaime Cerda | Shingo Takatsu | 858 | 821 | 37 |
| 2004-10-02 | @ KCA | 161 | L 2-10 | 82-79 | 2 | 16,028 | Jason Grilli | Brian Anderson | Brian Anderson | Jason Grilli | | 860 | 831 | 29 |
| 2004-10-03 | @ KCA | 162 | W 5-0 | 83-79 | 2 | 14,586 | Jose Contreras | Zack Greinke | Jose Contreras | Zack Greinke | | 865 | 831 | 34 |