| 40 | Bartolo Colon | - | 6 | 34 | 34 | 242.0 | 3.87 | 1.20 | 8.29 | 1.12 | 2.49 | 6.43 | 0.39 | 0.63 | 22 | 5 | 899 | .248 | 984 | 3.61 | 34.6 | 65.4 | 8.0 |
| 56 | Mark Buehrle | - | 18 | 35 | 35 | 230.1 | 4.14 | 1.35 | 9.77 | 0.86 | 2.38 | 4.65 | 0.51 | 0.87 | 24 | 5 | 898 | .278 | 978 | 3.57 | 36.0 | 64.0 | 6.9 |
| 21 | Esteban Loaiza | - | 2 | 34 | 34 | 226.1 | 2.90 | 1.11 | 7.79 | 0.68 | 2.23 | 8.23 | 0.27 | 0.95 | 27 | 10 | 843 | .233 | 922 | 3.81 | 33.8 | 66.2 | 9.0 |
| 20 | Jon Garland | - | 44 | 32 | 32 | 191.2 | 4.51 | 1.37 | 8.83 | 1.31 | 3.47 | 5.07 | 0.69 | 0.92 | 18 | 4 | 722 | .260 | 813 | 3.76 | 38.4 | 61.6 | 6.9 |
| 46 | Danny Wright | - | - | 20 | 15 | 86.1 | 6.15 | 1.59 | 9.49 | 1.67 | 4.80 | 4.90 | 0.98 | 0.68 | 5 | 3 | 329 | .277 | 388 | 3.86 | 42.3 | 57.7 | 6.0 |
| 43 | Damaso Marte | - | 65 | 71 | 0 | 79.2 | 1.58 | 1.05 | 5.65 | 0.34 | 3.84 | 9.83 | 0.39 | 0.59 | 0 | 3 | 271 | .185 | 314 | 4.10 | 37.6 | 62.4 | 10.5 |
| 36 | Tom Gordon | - | 62 | 66 | 0 | 74.0 | 3.16 | 1.19 | 6.93 | 0.49 | 3.77 | 11.07 | 0.34 | 0.89 | 0 | 4 | 268 | .213 | 310 | 3.99 | 35.4 | 64.6 | 14.2 |
| 44 | Billy Koch | - | 58 | 55 | 0 | 53.0 | 5.77 | 1.64 | 10.02 | 1.70 | 4.75 | 7.13 | 0.67 | 0.71 | 0 | 1 | 210 | .281 | 244 | 3.73 | 39.6 | 60.4 | 9.0 |
| 50 | Rick White | - | - | 34 | 0 | 47.2 | 6.61 | 1.45 | 10.57 | 2.08 | 2.45 | 6.99 | 0.35 | 0.88 | 0 | 1 | 190 | .295 | 207 | 3.61 | 36.1 | 63.9 | 10.0 |
| 65 | Kelly Wunsch | - | - | 43 | 0 | 36.0 | 2.75 | 1.17 | 4.25 | 0.25 | 6.25 | 8.25 | 0.76 | 1.16 | 0 | 7 | 122 | .139 | 160 | 3.98 | 41.8 | 58.2 | 7.9 |
| 38 | Gary Glover | - | - | 24 | 0 | 35.2 | 4.54 | 1.60 | 10.85 | 0.76 | 3.53 | 5.80 | 0.61 | 0.73 | 0 | 0 | 0 | -- | 0 | -- | 38.9 | 61.1 | 8.2 |
| 60 | Scott Schoeneweis | - | - | 20 | 0 | 26.0 | 4.50 | 1.35 | 9.00 | 0.35 | 3.12 | 9.35 | 0.33 | 1.11 | 0 | 0 | 0 | -- | 0 | -- | 35.1 | 64.9 | 9.5 |
| 48 | Josh Stewart | - | - | 5 | 5 | 25.2 | 5.96 | 1.71 | 9.82 | 1.40 | 5.61 | 4.56 | 1.23 | 0.92 | 2 | 0 | 103 | .272 | 121 | 4.01 | 42.7 | 57.3 | 3.7 |
| 52 | Dave Sanders | - | - | 20 | 0 | 22.0 | 6.14 | 1.64 | 10.23 | 2.05 | 4.50 | 5.73 | 0.79 | 0.52 | 0 | 1 | 89 | .281 | 102 | 4.02 | 39.5 | 60.5 | 7.8 |
| 47 | Scott Sullivan | - | - | 15 | 0 | 14.1 | 3.77 | 1.05 | 5.65 | 1.26 | 3.77 | 8.16 | 0.46 | 0.52 | 0 | 0 | 0 | -- | 0 | -- | 36.1 | 63.9 | 13.7 |
| 41 | Mike Porzio | - | - | 3 | 3 | 14.0 | 6.43 | 1.36 | 11.57 | 1.29 | 0.64 | 5.79 | 0.11 | 0.85 | 0 | 2 | 56 | .321 | 62 | 3.40 | 35.5 | 64.5 | 6.6 |
| 38 | Neal Cotts | - | - | 4 | 4 | 13.1 | 8.10 | 2.40 | 10.13 | 0.68 | 11.48 | 6.75 | 1.70 | 0.75 | 0 | 0 | 51 | .294 | 69 | 4.46 | 45.1 | 54.9 | 8.1 |
| 37 | Jonathan Adkins | - | - | 4 | 0 | 9.1 | 4.82 | 1.61 | 7.71 | 0.96 | 6.75 | 2.89 | 2.33 | 0.72 | 0 | 1 | 32 | .250 | 42 | 4.14 | 40.8 | 59.2 | 5.2 |
| 32 | Matt Ginter | - | - | 3 | 0 | 3.1 | 13.50 | 0.90 | 5.40 | 2.70 | 2.70 | 0.00 | -- | 1.00 | 0 | 2 | 11 | .182 | 15 | 3.13 | 46.8 | 53.2 | 0.0 |
| 50 | Jose Paniagua | - | - | 1 | 0 | 0.1 | 108.00 | 12.00 | 81.00 | -- | 27.00 | 0.00 | -- | 0.33 | 0 | 0 | 4 | .750 | 5 | 2.40 | 50.0 | 50.0 | 8.3 |