| - | Arian Alcala | 3B | A | 6-2 | 205 | Right | Right | 10/7/1979 | 23 | Hialeah,Florida | 2002 | 17 | 508 | BOS |
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| - | Matt Blaney | P | A+ | 5-11 | 180 | Both | Right | 5/7/1979 | 24 | Vero Beach,Florida | 2001 | UDFA | | LAD |
| - | Brett Bonvechio | 1B | AA | 6-1 | 190 | Left | Right | 11/13/1982 | 20 | San Jose,California | 2000 | 37 | 1112 | BOS |
| - | Addison Bowman | C | A+ | 6-2 | 205 | Right | Right | 8/31/1979 | 23 | Harrisonburg,Virginia | 2002 | UDFA | | BOS |
| - | Dustin Brisson | 1B | AA | 6-3 | 210 | Left | Right | 3/18/1978 | 25 | Boynton Beach,Florida | 2000 | 15 | 452 | BOS |
| - | Dusty Brown | C | MLB | 6-0 | 180 | Right | Right | 6/19/1982 | 21 | Orange,California | 2000 | 35 | 1052 | BOS |
| - | Jason Bryan | OF | A+ | 6-2 | 195 | Right | Right | 11/18/1981 | 21 | Brooklyn,New York | 1999 | 10 | 315 | TEX |
| - | Osmar Castillo | 2B | A+ | 5-10 | 175 | Both | Right | 1/3/1979 | 24 | Valencia,Venezuela | 2002 | UDFA | | BOS |
| - | Juan Cedeno | P | AAA | 6-1 | 160 | Left | Left | 8/19/1983 | 19 | Higuey,Dominican Republic | 2001 | UDFA | | BOS |
| - | James Clelland | P | A+ | 6-4 | 180 | Right | Right | 9/28/1979 | 23 | Mexico City,Mexico | 2001 | UDFA | | MTL |
| - | David Coffey | OF | A | 5-10 | 175 | Left | Right | 4/15/1981 | 22 | Perry,Georgia | 2003 | 23 | 684 | BOS |
| - | Matt Cooper | IF | A+ | 6-3 | 200 | Right | Right | 10/10/1980 | 22 | Stillwater,Oklahoma | 2000 | 3 | 92 | BOS |
| - | Willy Corporan | P | A+ | 6-4 | 220 | Right | Right | 9/2/1981 | 21 | San Pedro de Macoris,Dominican Republic | 2003 | UDFA | | BOS |
| - | Lee Curtis | 2B | A+ | 5-11 | 185 | Right | Right | 7/21/1981 | 21 | Greenville,South Carolina | 2003 | 8 | 234 | BOS |
| - | Michael Dennison | P | A+ | 6-0 | 200 | Right | Right | 1/9/1981 | 22 | Bismarck,North Dakota | 2003 | 21 | 624 | BOS |
| - | William Durazo | C-1B | A+ | 6-1 | 210 | Both | Right | 2/15/1979 | 24 | Los Angeles,California | 2002 | UDFA | | BOS |
| - | Chris Durbin | OF | AA | 6-0 | 180 | Right | Right | 9/8/1981 | 21 | Cherry Point,North Carolina | 2003 | 10 | 294 | BOS |
| - | Brian Esposito | C | MLB | 6-1 | 190 | Right | Right | 2/24/1979 | 24 | Staten Island,New York | 2000 | 5 | 152 | BOS |
| - | Parker Friske | P | A | 6-4 | 210 | Left | Left | 5/1/1979 | 24 | Annapolis,Maryland | 2001 | UDFA | | BOS |
| - | Willy Galvez | P | A | 6-4 | 162 | Right | Right | 4/2/1982 | 21 | Cotui,Dominican Republic | 1998 | UDFA | | BOS |
| - | Mike Garber | P | A+ | 6-2 | 190 | Left | Left | 1/9/1981 | 22 | Oak Lawn,Illinois | 2001 | 18 | 548 | ARI |
| - | Daniel Generelli | P | A | 6-2 | 200 | Right | Right | 8/25/1980 | 22 | Worcester,Massachusetts | 1999 | 20 | 619 | BOS |
| - | Mike Goss | OF | AA | 5-11 | 185 | Left | Right | 9/26/1980 | 22 | Ackerman,Mississippi | 2002 | 11 | 328 | BOS |
| - | Barry Hertzler | P | AAA | 6-2 | 205 | Right | Right | 2/15/1981 | 22 | Providence,Rhode Island | 2003 | 11 | 324 | BOS |
| - | Kevin Huang | P | A+ | 6-0 | 172 | Right | Right | 4/25/1982 | 21 | Pingtung,Taiwan | 2000 | UDFA | | BOS |
| - | Ryo Kumagai | P | AA | 6-0 | 180 | Right | Right | 8/22/1979 | 23 | Tokyo,Japan | 2002 | UDFA | | BOS |
| - | Jon Lester | P | MLB | 6-3 | 200 | Left | Left | 1/7/1984 | 19 | Tacoma,Washington | 2002 | 2 | 57 | BOS |
| - | Wayne Lundgren | P | A+ | 6-7 | 220 | Right | Right | 4/21/1982 | 21 | Thornleigh,Australia | 2000 | UDFA | | BOS |
| - | Tom MacLane | P | A | 5-11 | 170 | Left | Left | 2/2/1980 | 23 | Providence,Rhode Island | 2002 | 19 | 568 | BOS |
| - | Aneudis Mateo | P | A | 6-4 | 180 | Right | Right | 10/3/1982 | 20 | San Pedro de Macoris,Dominican Republic | 2000 | UDFA | | BOS |
| - | Luis Mendoza | P | MLB | 6-3 | 180 | Right | Right | 10/31/1983 | 19 | Veracruz,Mexico | 2000 | UDFA | | BOS |
| - | Carlos Morla | P | AAA | 6-0 | 140 | Right | Right | 4/15/1982 | 21 | El Seybo,Dominican Republic | 1999 | UDFA | | BOS |
| - | Kenton Myers | C | AAA | 6-1 | 200 | Right | Right | 4/14/1980 | 23 | Albuquerque,New Mexico | 2001 | 23 | 697 | CLE |
| - | Jeff Ontiveros | 1B | A+ | 6-0 | 220 | Right | Right | 4/26/1979 | 24 | Georgetown,Texas | 2002 | UDFA | | BOS |
| - | Dave Pahucki | P | AA | 6-2 | 200 | Right | Right | 10/17/1980 | 22 | Middletown,New York | 2002 | 23 | 688 | BOS |
| - | John Priola | P | A | 6-3 | 190 | Right | Right | 9/30/1979 | 23 | Pensacola,Florida | 2002 | 14 | 418 | BOS |
| - | Hanley Ramirez | 3B-SS | MLB | 6-3 | 200 | Right | Right | 12/23/1983 | 19 | Samana,Dominican Republic | 2000 | UDFA | | BOS |
| - | Angus Roy | P | A | 6-2 | 210 | Left | Right | 6/27/1980 | 23 | Mississauga,Ontario | 2002 | UDFA | | BOS |
| - | Andy Shipman | P | AAA | 6-2 | 175 | | Right | 12/10/1981 | 21 | Warrensburg,Missouri | 2003 | UDFA | | BOS |
| - | Brandon Smith | P | A | 6-3 | 196 | Right | Right | 2/18/1980 | 23 | Houston,Texas | 2002 | 18 | 538 | BOS |
| - | Jose Soto | OF | A+ | 6-2 | 160 | Both | Right | 6/18/1979 | 24 | San Cristobal,Dominican Republic | 1996 | UDFA | | FLA |
| - | Chad Spann | 3B | AAA | 6-1 | 190 | Right | Right | 10/25/1983 | 19 | Americus,Georgia | 2002 | 5 | 148 | BOS |
| - | Greg Stone | OF | A+ | 6-0 | 180 | Right | Right | 2/19/1981 | 22 | Tulsa,Oklahoma | 2002 | 10 | 298 | BOS |
| - | Justin Sturge | P | AA | 6-4 | 190 | Right | Left | 5/4/1981 | 22 | Syracuse,New York | 2003 | 12 | 354 | BOS |
| - | Milton Tavarez | P | A+ | 6-2 | 190 | Right | Right | 3/29/1982 | 21 | Higuey,Dominican Republic | 1999 | UDFA | | BOS |
| - | Matt Thompson | P | A+ | 6-1 | 205 | Right | Right | 8/28/1981 | 21 | Boise,Idaho | 1999 | 2 | 76 | BOS |
| - | Fernando Veracierto | OF | A+ | 5-11 | 170 | Right | Right | 8/18/1982 | 20 | Maiquetia,Venezuela | 1999 | UDFA | | FLA |
| - | Luis Villarreal | P | AAA | 6-1 | 208 | Left | Left | 12/20/1979 | 23 | San Antonio,Texas | 2002 | 20 | 598 | BOS |
| - | Eric West | 2B | A | 6-1 | 160 | Right | Right | 3/24/1983 | 20 | Birmingham,Alabama | 2001 | 5 | 153 | BOS |