| 2002-04-02 | vs DET | 1 | W 9-5 | 1-0 | 2 | 38,142 | Tanyon Sturtze | Jeff Weaver | Victor Zambrano | Juan Acevedo | | 9 | 5 | 4 |
| 2002-04-03 | vs DET | 2 | W 2-1 | 2-0 | 1 | 15,186 | Paul Wilson | Steve Sparks | Jesus Colome | Jeff Farnsworth | | 11 | 6 | 5 |
| 2002-04-04 | vs DET | 3 | W 9-2 | 3-0 | 1 | 14,204 | Ryan Rupe | Jose Lima | Ryan Rupe | Jose Lima | | 20 | 8 | 12 |
| 2002-04-05 | @ NYA | 4 | L 0-4 | 3-1 | 2 | 55,771 | Joe Kennedy | Andy Pettitte | Andy Pettitte | Joe Kennedy | | 20 | 12 | 8 |
| 2002-04-06 | @ NYA | 5 | L 0-3 | 3-2 | 3 | 39,093 | Wilson Alvarez | Orlando Hernandez | Orlando Hernandez | Wilson Alvarez | Mariano Rivera | 20 | 15 | 5 |
| 2002-04-07 | @ NYA | 6 | L 2-7 | 3-3 | 3 | 37,343 | Tanyon Sturtze | Roger Clemens | Roger Clemens | Tanyon Sturtze | | 22 | 22 | 0 |
| 2002-04-10 | @ BAL | 7 | W 3-2 | 4-3 | 3 | 22,781 | Paul Wilson | Jason Johnson | Paul Wilson | Jason Johnson | Esteban Yan | 25 | 24 | 1 |
| 2002-04-11 | @ BAL | 8 | L 6-15 | 4-4 | 3 | 24,179 | Joe Kennedy | Sidney Ponson | Rodrigo Lopez | Jesus Colome | | 31 | 39 | -8 |
| 2002-04-12 | vs TOR | 9 | L 7-14 | 4-5 | 4 | 11,058 | Ryan Rupe | Brian Cooper | Justin Miller | Ryan Rupe | | 38 | 53 | -15 |
| 2002-04-13 | vs TOR | 10 | L 4-5 | 4-6 | 4 | 11,143 | Tanyon Sturtze | Luke Prokopec | Luke Prokopec | Tanyon Sturtze | Kelvim Escobar | 42 | 58 | -16 |
| 2002-04-14 | vs TOR | 11 | W 5-4 | 5-6 | 4 | 11,222 | Wilson Alvarez | Roy Halladay | Esteban Yan | Pasqual Coco | | 47 | 62 | -15 |
| 2002-04-16 | @ DET | 12 | L 3-9 | 5-7 | 4 | 13,256 | Delvin James | Jose Lima | Jose Lima | Delvin James | | 50 | 71 | -21 |
| 2002-04-17 | @ DET | 13 | L 6-7 | 5-8 | 4 | 10,736 | Joe Kennedy | Mark Redman | Matt Anderson | Victor Zambrano | | 56 | 78 | -22 |
| 2002-04-18 | @ DET | 14 | W 6-4 | 6-8 | 3 | 21,971 | Ryan Rupe | Jeff Weaver | Ryan Rupe | Jeff Weaver | Esteban Yan | 62 | 82 | -20 |
| 2002-04-19 | vs BAL | 15 | L 5-6 | 6-9 | 3 | 11,124 | Tanyon Sturtze | Calvin Maduro | Jorge Julio | Jesus Colome | | 67 | 88 | -21 |
| 2002-04-20 | vs BAL | 16 | L 3-6 | 6-10 | 4 | 11,402 | Paul Wilson | Jason Johnson | Jason Johnson | Paul Wilson | Willis Roberts | 70 | 94 | -24 |
| 2002-04-21 | vs BAL | 17 | W 2-1 | 7-10 | 3 | 13,091 | Delvin James | Sidney Ponson | Doug Creek | Sidney Ponson | Esteban Yan | 72 | 95 | -23 |
| 2002-04-23 | vs MIN | 18 | W 6-4 | 8-10 | 3 | 10,602 | Joe Kennedy | Brad Radke | Joe Kennedy | Brad Radke | Esteban Yan | 78 | 99 | -21 |
| 2002-04-24 | vs MIN | 19 | W 9-1 | 9-10 | 3 | 10,761 | Ryan Rupe | Eric Milton | Ryan Rupe | Eric Milton | | 87 | 100 | -13 |
| 2002-04-25 | vs MIN | 20 | L 2-6 | 9-11 | 3 | 10,623 | Tanyon Sturtze | Kyle Lohse | Michael Jackson | Esteban Yan | | 89 | 106 | -17 |
| 2002-04-26 | @ BOS | 21 | L 2-4 | 9-12 | 3 | 32,292 | Paul Wilson | John Burkett | John Burkett | Paul Wilson | Ugueth Urbina | 91 | 110 | -19 |
| 2002-04-27 | @ BOS | 22 | L 0-10 | 9-13 | 4 | 32,837 | Delvin James | Derek Lowe | Derek Lowe | Delvin James | | 91 | 120 | -29 |
| 2002-04-29 | @ MIN | 23 | L 2-3 | 9-14 | 4 | 11,390 | Joe Kennedy | Eric Milton | Eric Milton | Joe Kennedy | Eddie Guardado | 93 | 123 | -30 |
| 2002-04-30 | @ MIN | 24 | L 3-6 | 9-15 | 4 | 10,205 | Ryan Rupe | Kyle Lohse | Kyle Lohse | Ryan Rupe | Eddie Guardado | 96 | 129 | -33 |
| 2002-05-01 | @ MIN | 25 | L 3-5 | 9-16 | 4 | 12,691 | Tanyon Sturtze | Rick Reed | Rick Reed | Tanyon Sturtze | Eddie Guardado | 99 | 134 | -35 |
| 2002-05-02 | @ MIN | 26 | L 6-7 | 9-17 | 4 | 14,106 | Paul Wilson | Matt Kinney | Tony Fiore | Steven Kent | | 105 | 141 | -36 |
| 2002-05-03 | vs BOS | 27 | L 2-3 | 9-18 | 4 | 12,583 | Delvin James | John Burkett | Casey Fossum | Jesus Colome | Ugueth Urbina | 107 | 144 | -37 |
| 2002-05-04 | vs BOS | 28 | L 5-7 | 9-19 | 4 | 17,972 | Joe Kennedy | Derek Lowe | Sun-Woo Kim | Victor Zambrano | Ugueth Urbina | 112 | 151 | -39 |
| 2002-05-05 | vs BOS | 29 | L 0-2 | 9-20 | 4 | 15,920 | Ryan Rupe | Frank Castillo | Frank Castillo | Ryan Rupe | Ugueth Urbina | 112 | 153 | -41 |
| 2002-05-06 | vs BOS | 30 | L 3-5 | 9-21 | 5 | 11,564 | Tanyon Sturtze | Darren Oliver | Darren Oliver | Tanyon Sturtze | Tim Wakefield | 115 | 158 | -43 |
| 2002-05-07 | vs NYA | 31 | L 2-5 | 9-22 | 5 | 15,031 | Paul Wilson | Mike Mussina | Mike Mussina | Paul Wilson | Mariano Rivera | 117 | 163 | -46 |
| 2002-05-08 | vs NYA | 32 | L 2-7 | 9-23 | 5 | 15,263 | Delvin James | Roger Clemens | Roger Clemens | Delvin James | | 119 | 170 | -51 |
| 2002-05-09 | vs NYA | 33 | L 1-3 | 9-24 | 5 | 16,013 | Joe Kennedy | Orlando Hernandez | Orlando Hernandez | Joe Kennedy | Mariano Rivera | 120 | 173 | -53 |
| 2002-05-10 | vs BAL | 34 | L 5-6 | 9-25 | 5 | 10,635 | Ryan Rupe | Rodrigo Lopez | Rodrigo Lopez | Ryan Rupe | Jorge Julio | 125 | 179 | -54 |
| 2002-05-11 | vs BAL | 35 | W 6-4 | 10-25 | 5 | 10,811 | Tanyon Sturtze | Calvin Maduro | Esteban Yan | Jorge Julio | | 131 | 183 | -52 |
| 2002-05-12 | vs BAL | 36 | W 6-3 | 11-25 | 5 | 10,264 | Paul Wilson | Sidney Ponson | Paul Wilson | Sidney Ponson | Esteban Yan | 137 | 186 | -49 |
| 2002-05-14 | @ NYA | 37 | L 3-10 | 11-26 | 5 | 29,503 | Travis Harper | Roger Clemens | Roger Clemens | Travis Harper | | 140 | 196 | -56 |
| 2002-05-15 | @ NYA | 38 | W 10-7 | 12-26 | 5 | 26,571 | Joe Kennedy | Orlando Hernandez | Joe Kennedy | Orlando Hernandez | Esteban Yan | 150 | 203 | -53 |
| 2002-05-16 | @ NYA | 39 | L 0-13 | 12-27 | 5 | 32,695 | Ryan Rupe | David Wells | David Wells | Ryan Rupe | | 150 | 216 | -66 |
| 2002-05-17 | @ BAL | 40 | L 3-5 | 12-28 | 5 | 36,914 | Tanyon Sturtze | Calvin Maduro | Willis Roberts | Victor Zambrano | Jorge Julio | 153 | 221 | -68 |
| 2002-05-18 | @ BAL | 41 | W 5-4 | 13-28 | 5 | 35,093 | Paul Wilson | Sidney Ponson | Doug Creek | Rick Bauer | Esteban Yan | 158 | 225 | -67 |
| 2002-05-19 | @ BAL | 42 | W 4-0 | 14-28 | 5 | 37,590 | Travis Harper | Scott Erickson | Travis Harper | Scott Erickson | Steven Kent | 162 | 225 | -63 |
| 2002-05-21 | @ SEA | 43 | W 1-0 | 15-28 | 5 | 41,845 | Joe Kennedy | Jamie Moyer | Joe Kennedy | Jamie Moyer | | 163 | 225 | -62 |
| 2002-05-22 | @ SEA | 44 | W 3-2 | 16-28 | 5 | 39,734 | Ryan Rupe | Joel Pineiro | Ryan Rupe | Joel Pineiro | Esteban Yan | 166 | 227 | -61 |
| 2002-05-23 | @ SEA | 45 | L 3-7 | 16-29 | 5 | 45,227 | Tanyon Sturtze | James Baldwin | James Baldwin | Tanyon Sturtze | | 169 | 234 | -65 |
| 2002-05-24 | @ OAK | 46 | L 8-9 | 16-30 | 5 | 25,458 | Paul Wilson | Tim Hudson | Jim Mecir | Victor Zambrano | Billy Koch | 177 | 243 | -66 |
| 2002-05-25 | @ OAK | 47 | L 0-6 | 16-31 | 5 | 31,697 | Travis Harper | Aaron Harang | Aaron Harang | Travis Harper | Chad Bradford | 177 | 249 | -72 |
| 2002-05-26 | @ OAK | 48 | L 0-7 | 16-32 | 5 | 15,943 | Joe Kennedy | Barry Zito | Barry Zito | Joe Kennedy | | 177 | 256 | -79 |
| 2002-05-28 | vs SEA | 49 | W 5-1 | 17-32 | 4 | 10,810 | Ryan Rupe | Joel Pineiro | Ryan Rupe | Joel Pineiro | | 182 | 257 | -75 |
| 2002-05-29 | vs SEA | 50 | L 2-5 | 17-33 | 4 | 10,586 | Tanyon Sturtze | Freddy Garcia | Freddy Garcia | Tanyon Sturtze | Kazuhiro Sasaki | 184 | 262 | -78 |
| 2002-05-30 | vs OAK | 51 | W 4-3 | 18-33 | 4 | 10,130 | Paul Wilson | Tim Hudson | Travis Harper | Chad Bradford | | 188 | 265 | -77 |
| 2002-05-31 | vs OAK | 52 | L 9-13 | 18-34 | 5 | 10,227 | Wilson Alvarez | Cory Lidle | Mike Venafro | Esteban Yan | | 197 | 278 | -81 |
| 2002-06-01 | vs OAK | 53 | L 3-8 | 18-35 | 5 | 14,073 | Joe Kennedy | Barry Zito | Barry Zito | Joe Kennedy | | 200 | 286 | -86 |
| 2002-06-02 | vs OAK | 54 | L 2-4 | 18-36 | 5 | 10,563 | Ryan Rupe | Mark Mulder | Mark Mulder | Ryan Rupe | Billy Koch | 202 | 290 | -88 |
| 2002-06-03 | @ TOR | 55 | L 1-6 | 18-37 | 5 | 13,002 | Tanyon Sturtze | Pete Walker | Pete Walker | Tanyon Sturtze | | 203 | 296 | -93 |
| 2002-06-04 | @ TOR | 56 | L 1-3 | 18-38 | 5 | 13,162 | Paul Wilson | Justin Miller | Justin Miller | Paul Wilson | Kelvim Escobar | 204 | 299 | -95 |
| 2002-06-05 | @ TOR | 57 | W 8-6 | 19-38 | 5 | 13,643 | Wilson Alvarez | Esteban Loaiza | Wilson Alvarez | Esteban Loaiza | | 212 | 305 | -93 |
| 2002-06-06 | @ TOR | 58 | L 4-5 | 19-39 | 5 | 24,069 | Joe Kennedy | Luke Prokopec | Kelvim Escobar | Travis Harper | | 216 | 310 | -94 |
| 2002-06-07 | vs SDN | 59 | L 4-8 | 19-40 | 5 | 10,578 | Ryan Rupe | Brian Lawrence | Brian Lawrence | Ryan Rupe | | 220 | 318 | -98 |
| 2002-06-08 | vs SDN | 60 | W 3-2 | 20-40 | 5 | 14,039 | Tanyon Sturtze | Brett Tomko | Victor Zambrano | Alan Embree | | 223 | 320 | -97 |
| 2002-06-09 | vs SDN | 61 | L 6-9 | 20-41 | 5 | 13,286 | Paul Wilson | Robert Joseph Jones | Robert Joseph Jones | Paul Wilson | Trevor Hoffman | 229 | 329 | -100 |
| 2002-06-10 | vs LAN | 62 | L 5-10 | 20-42 | 5 | 10,905 | Wilson Alvarez | Hideo Nomo | Hideo Nomo | Wilson Alvarez | | 234 | 339 | -105 |
| 2002-06-11 | vs LAN | 63 | W 11-2 | 21-42 | 5 | 11,416 | Joe Kennedy | Omar Daal | Joe Kennedy | Omar Daal | | 245 | 341 | -96 |
| 2002-06-12 | vs LAN | 64 | L 2-4 | 21-43 | 5 | 11,083 | Ryan Rupe | Andy Ashby | Andy Ashby | Ryan Rupe | Eric Gagne | 247 | 345 | -98 |
| 2002-06-14 | @ FLO | 65 | W 4-3 | 22-43 | 5 | 9,580 | Tanyon Sturtze | Julian Tavarez | Esteban Yan | Oswaldo Mairena | Travis Harper | 251 | 348 | -97 |
| 2002-06-15 | @ FLO | 66 | L 0-3 | 22-44 | 5 | 10,904 | Paul Wilson | A.J. Burnett | A.J. Burnett | Paul Wilson | | 251 | 351 | -100 |
| 2002-06-16 | @ FLO | 67 | W 4-1 | 23-44 | 5 | 9,380 | Wilson Alvarez | Michael Tejera | Victor Zambrano | Armando Almanza | Esteban Yan | 255 | 352 | -97 |
| 2002-06-18 | @ SFN | 68 | W 8-3 | 24-44 | 5 | 36,869 | Joe Kennedy | Livan Hernandez | Joe Kennedy | Livan Hernandez | | 263 | 355 | -92 |
| 2002-06-19 | @ SFN | 69 | L 0-8 | 24-45 | 5 | 35,909 | Ryan Rupe | Jason Schmidt | Jason Schmidt | Ryan Rupe | | 263 | 363 | -100 |
| 2002-06-20 | @ SFN | 70 | L 2-10 | 24-46 | 5 | 39,101 | Tanyon Sturtze | Russ Ortiz | Russ Ortiz | Tanyon Sturtze | | 265 | 373 | -108 |
| 2002-06-21 | @ COL | 71 | L 7-8 | 24-47 | 5 | 30,284 | Paul Wilson | Shawn Chacon | Justin Speier | Esteban Yan | | 272 | 381 | -109 |
| 2002-06-22 | @ COL | 72 | L 5-6 | 24-48 | 5 | 31,190 | Wilson Alvarez | Denny Neagle | Jose Jimenez | Steven Kent | | 277 | 387 | -110 |
| 2002-06-23 | @ COL | 73 | L 5-6 | 24-49 | 5 | 31,043 | Joe Kennedy | Jason Jennings | Rick White | Joe Kennedy | Jose Jimenez | 282 | 393 | -111 |
| 2002-06-25 | vs TOR | 74 | L 11-20 | 24-50 | 5 | 10,380 | Jorge Sosa | Esteban Loaiza | Pete Walker | Jorge Sosa | | 293 | 413 | -120 |
| 2002-06-26 | vs TOR | 75 | W 4-2 | 25-50 | 5 | 10,154 | Tanyon Sturtze | Steve Parris | Tanyon Sturtze | Steve Parris | Esteban Yan | 297 | 415 | -118 |
| 2002-06-27 | vs TOR | 76 | W 6-4 | 26-50 | 5 | 10,328 | Paul Wilson | Chris Carpenter | Travis Harper | Cliff Politte | Esteban Yan | 303 | 419 | -116 |
| 2002-06-28 | vs FLO | 77 | W 4-0 | 27-50 | 5 | 10,831 | Wilson Alvarez | Ryan Dempster | Wilson Alvarez | Ryan Dempster | | 307 | 419 | -112 |
| 2002-06-29 | vs FLO | 78 | L 2-3 | 27-51 | 5 | 15,874 | Joe Kennedy | Julian Tavarez | Julian Tavarez | Joe Kennedy | Vladimir Nunez | 309 | 422 | -113 |
| 2002-06-30 | vs FLO | 79 | W 6-5 | 28-51 | 5 | 12,273 | Jorge Sosa | A.J. Burnett | Esteban Yan | Vladimir Nunez | | 315 | 427 | -112 |
| 2002-07-02 | @ TEX | 80 | L 1-3 | 28-52 | 5 | 20,295 | Tanyon Sturtze | Kenny Rogers | Kenny Rogers | Tanyon Sturtze | Hideki Irabu | 316 | 430 | -114 |
| 2002-07-03 | @ TEX | 81 | L 5-6 | 28-53 | 5 | 30,762 | Paul Wilson | Ismael Valdez | John Rocker | Jesus Colome | | 321 | 436 | -115 |
| 2002-07-04 | @ TEX | 82 | L 8-11 | 28-54 | 5 | 48,719 | Wilson Alvarez | Rob Bell | Colby Lewis | Travis Harper | Hideki Irabu | 329 | 447 | -118 |
| 2002-07-05 | @ ANA | 83 | L 5-6 | 28-55 | 5 | 23,648 | Joe Kennedy | Aaron Sele | Scot Shields | Esteban Yan | | 334 | 453 | -119 |
| 2002-07-06 | @ ANA | 84 | L 3-4 | 28-56 | 5 | 29,513 | Jorge Sosa | John Lackey | Scott Schoeneweis | Jesus Colome | Troy Percival | 337 | 457 | -120 |
| 2002-07-07 | @ ANA | 85 | L 1-2 | 28-57 | 5 | 26,446 | Tanyon Sturtze | Ramon Ortiz | Troy Percival | Travis Harper | | 338 | 459 | -121 |
| 2002-07-11 | vs SEA | 86 | L 0-4 | 28-58 | 5 | 10,840 | Joe Kennedy | Joel Pineiro | Joel Pineiro | Joe Kennedy | | 338 | 463 | -125 |
| 2002-07-12 | vs SEA | 87 | L 1-2 | 28-59 | 5 | 12,095 | Paul Wilson | Jamie Moyer | Jamie Moyer | Travis Harper | Kazuhiro Sasaki | 339 | 465 | -126 |
| 2002-07-13 | vs SEA | 88 | W 4-3 | 29-59 | 5 | 15,840 | Tanyon Sturtze | James Baldwin | Esteban Yan | John Halama | | 343 | 468 | -125 |
| 2002-07-14 | vs SEA | 89 | L 6-7 | 29-60 | 5 | 14,267 | Wilson Alvarez | Freddy Garcia | Mark Watson | Travis Phelps | Kazuhiro Sasaki | 349 | 475 | -126 |
| 2002-07-15 | vs OAK | 90 | L 0-4 | 29-61 | 5 | 10,116 | Ryan Rupe | Ted Lilly | Ted Lilly | Ryan Rupe | | 349 | 479 | -130 |
| 2002-07-16 | vs OAK | 91 | L 1-2 | 29-62 | 5 | 10,592 | Jorge Sosa | Mark Mulder | Mark Mulder | Jorge Sosa | Billy Koch | 350 | 481 | -131 |
| 2002-07-17 | vs BOS | 92 | L 1-6 | 29-63 | 5 | 15,672 | Paul Wilson | Derek Lowe | Derek Lowe | Paul Wilson | | 351 | 487 | -136 |
| 2002-07-18 | vs BOS | 93 | L 3-4 | 29-64 | 5 | 22,012 | Tanyon Sturtze | Frank Castillo | Tim Wakefield | Esteban Yan | Ugueth Urbina | 354 | 491 | -137 |
| 2002-07-19 | @ TOR | 94 | L 8-11 | 29-65 | 5 | 16,985 | Joe Kennedy | Esteban Loaiza | Esteban Loaiza | Doug Creek | Kelvim Escobar | 362 | 502 | -140 |
| 2002-07-20 | @ TOR | 95 | L 10-12 | 29-66 | 5 | 24,449 | Luis de los Santos | Steve Parris | Steve Parris | Luis de los Santos | Kelvim Escobar | 372 | 514 | -142 |
| 2002-07-21 | @ TOR | 96 | W 7-5 | 30-66 | 5 | 21,442 | Jorge Sosa | Pete Walker | Jorge Sosa | Pete Walker | Esteban Yan | 379 | 519 | -140 |
| 2002-07-23 | @ BOS | 97 | L 4-22 | 31-67 | 5 | 33,190 | Tanyon Sturtze | Tim Wakefield | Tim Wakefield | Tanyon Sturtze | Willie Banks | 383 | 541 | -158 |
| 2002-07-23 | @ BOS | 98 | W 5-4 | 31-67 | 5 | 32,729 | Paul Wilson | Derek Lowe | Victor Zambrano | Ugueth Urbina | Esteban Yan | 388 | 545 | -157 |
| 2002-07-24 | @ BOS | 99 | W 9-5 | 32-67 | 5 | 32,969 | Joe Kennedy | Frank Castillo | Jesus Colome | Frank Castillo | Victor Zambrano | 397 | 550 | -153 |
| 2002-07-25 | @ BOS | 100 | L 0-6 | 32-68 | 5 | 33,439 | Luis de los Santos | Pedro Martinez | Pedro Martinez | Luis de los Santos | | 397 | 556 | -159 |
| 2002-07-26 | vs NYA | 101 | L 9-12 | 32-69 | 5 | 22,527 | Jorge Sosa | Mike Mussina | Mike Mussina | Jorge Sosa | Steve Karsay | 406 | 568 | -162 |
| 2002-07-27 | vs NYA | 102 | W 7-4 | 33-69 | 5 | 35,021 | Travis Harper | Jeff Weaver | Travis Harper | Jeff Weaver | Esteban Yan | 413 | 572 | -159 |
| 2002-07-28 | vs NYA | 103 | L 1-9 | 33-70 | 5 | 29,144 | Tanyon Sturtze | Andy Pettitte | Andy Pettitte | Tanyon Sturtze | | 414 | 581 | -167 |
| 2002-07-29 | vs BAL | 104 | W 6-1 | 34-70 | 5 | 10,340 | Paul Wilson | Travis Driskill | Paul Wilson | Travis Driskill | | 420 | 582 | -162 |
| 2002-07-30 | vs BAL | 105 | W 10-3 | 35-70 | 5 | 10,566 | Joe Kennedy | John Stephens | Joe Kennedy | John Stephens | | 430 | 585 | -155 |
| 2002-07-31 | vs BAL | 106 | L 2-12 | 35-71 | 5 | 10,933 | Luis de los Santos | Rodrigo Lopez | Rodrigo Lopez | Luis de los Santos | | 432 | 597 | -165 |
| 2002-08-01 | vs BAL | 107 | L 3-4 | 35-72 | 5 | 10,377 | Jorge Sosa | Sidney Ponson | Sidney Ponson | Jorge Sosa | Jorge Julio | 435 | 601 | -166 |
| 2002-08-02 | vs CHA | 108 | L 5-8 | 35-73 | 5 | 10,823 | Tanyon Sturtze | Gary Glover | Kelly Wunsch | Jesus Colome | Antonio Osuna | 440 | 609 | -169 |
| 2002-08-03 | vs CHA | 109 | W 6-2 | 36-73 | 5 | 11,963 | Paul Wilson | Todd Ritchie | Paul Wilson | Todd Ritchie | | 446 | 611 | -165 |
| 2002-08-04 | vs CHA | 110 | W 10-3 | 37-73 | 5 | 11,809 | Joe Kennedy | Mark Buehrle | Joe Kennedy | Mark Buehrle | | 456 | 614 | -158 |
| 2002-08-05 | vs CHA | 111 | L 3-4 | 37-74 | 5 | 10,769 | Victor Zambrano | Jon Garland | Keith Foulke | Esteban Yan | Damaso Marte | 459 | 618 | -159 |
| 2002-08-06 | @ CLE | 112 | L 2-4 | 37-75 | 5 | 35,302 | Jorge Sosa | Charles Nagy | Charles Nagy | Jorge Sosa | Mark Wohlers | 461 | 622 | -161 |
| 2002-08-07 | @ CLE | 113 | L 2-6 | 37-76 | 5 | 37,888 | Tanyon Sturtze | CC Sabathia | CC Sabathia | Tanyon Sturtze | | 463 | 628 | -165 |
| 2002-08-08 | @ CLE | 114 | W 4-2 | 38-76 | 5 | 29,973 | Paul Wilson | Danys Baez | Paul Wilson | Danys Baez | Esteban Yan | 467 | 630 | -163 |
| 2002-08-09 | @ KCA | 115 | L 4-5 | 38-77 | 5 | 23,003 | Joe Kennedy | Miguel Asencio | Darrell May | Travis Phelps | | 471 | 635 | -164 |
| 2002-08-10 | @ KCA | 116 | W 13-6 | 39-77 | 5 | 18,213 | Victor Zambrano | Shawn Sedlacek | Victor Zambrano | Shawn Sedlacek | Wilson Alvarez | 484 | 641 | -157 |
| 2002-08-11 | @ KCA | 117 | L 0-10 | 39-78 | 5 | 15,527 | Jorge Sosa | Runelvys Hernandez | Runelvys Hernandez | Jorge Sosa | | 484 | 651 | -167 |
| 2002-08-13 | vs CLE | 118 | L 5-9 | 39-79 | 5 | 11,779 | Tanyon Sturtze | CC Sabathia | CC Sabathia | Tanyon Sturtze | Mark Wohlers | 489 | 660 | -171 |
| 2002-08-14 | vs CLE | 119 | L 4-6 | 39-80 | 5 | 10,455 | Paul Wilson | Danys Baez | Danys Baez | Paul Wilson | Mark Wohlers | 493 | 666 | -173 |
| 2002-08-15 | vs CLE | 120 | W 4-3 | 40-80 | 5 | 10,778 | Joe Kennedy | Jake Westbrook | Travis Harper | Mark Wohlers | | 497 | 669 | -172 |
| 2002-08-16 | vs KCA | 121 | L 5-6 | 40-81 | 5 | 10,311 | Victor Zambrano | Shawn Sedlacek | Ryan Bukvich | Esteban Yan | Roberto Hernandez | 502 | 675 | -173 |
| 2002-08-17 | vs KCA | 122 | L 3-7 | 40-82 | 5 | 10,892 | Jorge Sosa | Darrell May | Scott Mullen | Jesus Colome | Roberto Hernandez | 505 | 682 | -177 |
| 2002-08-18 | vs KCA | 123 | W 8-6 | 41-82 | 5 | 10,607 | Tanyon Sturtze | Jeff Suppan | Tanyon Sturtze | Jeff Suppan | | 513 | 688 | -175 |
| 2002-08-19 | @ BAL | 124 | W 7-3 | 42-82 | 5 | 24,578 | Paul Wilson | Travis Driskill | Paul Wilson | Travis Driskill | | 520 | 691 | -171 |
| 2002-08-20 | @ BAL | 125 | L 4-7 | 42-83 | 5 | 24,647 | Joe Kennedy | Jason Johnson | Buddy Groom | Lee Gardner | | 524 | 698 | -174 |
| 2002-08-21 | @ BAL | 126 | L 1-2 | 42-84 | 5 | 27,591 | Victor Zambrano | Rodrigo Lopez | Rodrigo Lopez | Victor Zambrano | Buddy Groom | 525 | 700 | -175 |
| 2002-08-22 | @ BAL | 127 | L 2-3 | 42-85 | 5 | 21,447 | Jorge Sosa | John Stephens | Jorge Julio | Travis Harper | | 527 | 703 | -176 |
| 2002-08-23 | @ CHA | 128 | W 8-2 | 43-85 | 5 | 27,988 | Tanyon Sturtze | Jon Garland | Tanyon Sturtze | Jon Garland | | 535 | 705 | -170 |
| 2002-08-24 | @ CHA | 129 | L 2-5 | 43-86 | 5 | 24,580 | Paul Wilson | Dan Wright | Dan Wright | Paul Wilson | Damaso Marte | 537 | 710 | -173 |
| 2002-08-25 | @ CHA | 130 | L 3-8 | 43-87 | 5 | 20,340 | Joe Kennedy | Gary Glover | Gary Glover | Joe Kennedy | | 540 | 718 | -178 |
| 2002-08-27 | @ ANA | 131 | L 3-7 | 43-88 | 5 | 19,869 | Victor Zambrano | John Lackey | John Lackey | Victor Zambrano | Ben Weber | 543 | 725 | -182 |
| 2002-08-28 | @ ANA | 132 | W 8-5 | 44-88 | 5 | 17,740 | Jorge Sosa | Jarrod Washburn | Esteban Yan | Al Levine | | 551 | 730 | -179 |
| 2002-08-29 | @ ANA | 133 | L 1-6 | 44-89 | 5 | 18,820 | Tanyon Sturtze | Kevin Appier | Kevin Appier | Tanyon Sturtze | | 552 | 736 | -184 |
| 2002-08-30 | @ TEX | 134 | W 9-7 | 45-89 | 5 | 26,395 | Paul Wilson | Joaquin Benoit | Travis Phelps | Todd Van Poppel | Esteban Yan | 561 | 743 | -182 |
| 2002-08-31 | @ TEX | 135 | W 7-5 | 46-89 | 5 | 30,757 | Travis Harper | Kenny Rogers | Lee Gardner | Danny Kolb | Esteban Yan | 568 | 748 | -180 |
| 2002-09-01 | @ TEX | 136 | W 8-3 | 47-89 | 5 | 29,158 | Victor Zambrano | Dennys Reyes | Victor Zambrano | Dennys Reyes | Lance Carter | 576 | 751 | -175 |
| 2002-09-03 | vs ANA | 137 | L 2-10 | 47-90 | 5 | 10,146 | Jorge Sosa | Jarrod Washburn | Jarrod Washburn | Jorge Sosa | | 578 | 761 | -183 |
| 2002-09-04 | vs ANA | 138 | L 2-4 | 47-91 | 5 | 10,161 | Tanyon Sturtze | Kevin Appier | Kevin Appier | Tanyon Sturtze | Troy Percival | 580 | 765 | -185 |
| 2002-09-05 | vs ANA | 139 | L 1-10 | 47-92 | 5 | 10,135 | Joe Kennedy | Ramon Ortiz | Ramon Ortiz | Joe Kennedy | | 581 | 775 | -194 |
| 2002-09-06 | vs TEX | 140 | L 3-9 | 47-93 | 5 | 10,298 | Travis Harper | Dennys Reyes | Dennys Reyes | Travis Harper | Rich Rodriguez | 584 | 784 | -200 |
| 2002-09-07 | vs TEX | 141 | L 2-11 | 47-94 | 5 | 12,528 | Victor Zambrano | Chan Ho Park | Chan Ho Park | Victor Zambrano | | 586 | 795 | -209 |
| 2002-09-08 | vs TEX | 142 | W 6-3 | 48-94 | 5 | 11,779 | Jorge Sosa | Joaquin Benoit | Jorge Sosa | Joaquin Benoit | | 592 | 798 | -206 |
| 2002-09-09 | vs BOS | 143 | L 3-6 | 48-95 | 5 | 10,557 | Tanyon Sturtze | Derek Lowe | Derek Lowe | Tanyon Sturtze | Ugueth Urbina | 595 | 804 | -209 |
| 2002-09-10 | vs BOS | 144 | L 1-12 | 48-96 | 5 | 10,891 | Joe Kennedy | John Burkett | John Burkett | Joe Kennedy | | 596 | 816 | -220 |
| 2002-09-11 | vs BOS | 145 | L 3-6 | 48-97 | 5 | 12,415 | Paul Wilson | Pedro Martinez | Pedro Martinez | Paul Wilson | Ugueth Urbina | 599 | 822 | -223 |
| 2002-09-12 | vs BOS | 146 | L 3-6 | 48-98 | 5 | 10,149 | Victor Zambrano | Tim Wakefield | Tim Wakefield | Esteban Yan | Ugueth Urbina | 602 | 828 | -226 |
| 2002-09-13 | @ TOR | 147 | L 2-5 | 48-99 | 5 | 14,257 | Dewon Brazelton | Roy Halladay | Roy Halladay | Dewon Brazelton | Kelvim Escobar | 604 | 833 | -229 |
| 2002-09-14 | @ TOR | 148 | L 4-8 | 48-100 | 5 | 22,155 | Tanyon Sturtze | Mark Hendrickson | Mark Hendrickson | Tanyon Sturtze | Kelvim Escobar | 608 | 841 | -233 |
| 2002-09-15 | @ TOR | 149 | W 7-4 | 49-100 | 5 | 16,513 | Joe Kennedy | Esteban Loaiza | Joe Kennedy | Esteban Loaiza | Esteban Yan | 615 | 845 | -230 |
| 2002-09-17 | vs NYA | 150 | W 9-7 | 50-100 | 5 | 14,797 | Paul Wilson | Orlando Hernandez | Lance Carter | Ramiro Mendoza | | 624 | 852 | -228 |
| 2002-09-18 | vs NYA | 151 | L 1-7 | 50-101 | 5 | 14,993 | Victor Zambrano | Jeff Weaver | Jeff Weaver | Victor Zambrano | | 625 | 859 | -234 |
| 2002-09-19 | vs NYA | 152 | W 3-2 | 51-101 | 5 | 18,557 | Dewon Brazelton | Mike Mussina | Esteban Yan | Sterling Hitchcock | | 628 | 861 | -233 |
| 2002-09-20 | vs TOR | 153 | W 11-7 | 52-101 | 5 | 12,682 | Tanyon Sturtze | Esteban Loaiza | Tanyon Sturtze | Esteban Loaiza | | 639 | 868 | -229 |
| 2002-09-21 | vs TOR | 154 | W 4-3 | 53-101 | 5 | 13,351 | Joe Kennedy | Pete Walker | Lance Carter | Pete Walker | | 643 | 871 | -228 |
| 2002-09-22 | vs TOR | 155 | L 6-12 | 53-102 | 5 | 19,625 | Paul Wilson | Justin Miller | Justin Miller | Paul Wilson | | 649 | 883 | -234 |
| 2002-09-23 | @ NYA | 156 | W 3-2 | 54-102 | 5 | 31,937 | Victor Zambrano | Orlando Hernandez | Victor Zambrano | Orlando Hernandez | Esteban Yan | 652 | 885 | -233 |
| 2002-09-24 | @ NYA | 157 | L 0-6 | 54-103 | 5 | 32,492 | Travis Harper | Mike Mussina | Mike Mussina | Travis Harper | | 652 | 891 | -239 |
| 2002-09-25 | @ NYA | 158 | L 3-4 | 54-104 | 5 | 30,004 | Tanyon Sturtze | Roger Clemens | Jeff Weaver | Tanyon Sturtze | Mariano Rivera | 655 | 895 | -240 |
| 2002-09-27 | @ BOS | 159 | L 1-6 | 54-105 | 5 | 32,423 | Paul Wilson | John Burkett | John Burkett | Paul Wilson | | 656 | 901 | -245 |
| 2002-09-28 | @ BOS | 160 | W 9-6 | 55-105 | 5 | 32,623 | Victor Zambrano | Tim Wakefield | Victor Zambrano | Bob Howry | Lance Carter | 665 | 907 | -242 |
| 2002-09-29 | @ BOS | 161 | L 8-11 | 55-106 | 5 | 32,194 | Delvin James | Casey Fossum | Frank Castillo | Wilson Alvarez | Ugueth Urbina | 673 | 918 | -245 |