| Central | W | L | Pct | GB |
| Cleveland | 91 | 71 | .562 | -- |
| Minnesota | 85 | 77 | .525 | 6.0 |
| Chi White Sox | 83 | 79 | .512 | 8.0 |
| Detroit | 66 | 96 | .407 | 25.0 |
| KC Royals | 65 | 97 | .401 | 26.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2001-04-02 | Bartolo Colon | R | 26 | W 4-7 | vs CHA | 1 | 111 | L | 7.0 | 8 | 7 | 7 | 1 | 3 | 6 | 96 | 36 | 60 | 63% | 0-1 | 9.00 | 1.57 |
| 2001-04-04 | Chuck Finley | L | 38 | L 8-4 | vs CHA | 1 | 414 | W | 6.1 | 7 | 4 | 4 | 2 | 2 | 6 | 86 | 32 | 54 | 63% | 1-0 | 6.00 | 1.50 |
| 2001-04-06 | Dave Burba | R | 35 | L 4-3 | vs BAL | 1 | 185 | - | 6.2 | 6 | 3 | 3 | 0 | 1 | 8 | 100 | 31 | 69 | 69% | 0-0 | 3.86 | 1.00 |
| 2001-04-07 | Bartolo Colon | R | 26 | W 2-4 | vs BAL | 2 | 112 | - | 8.0 | 7 | 2 | 2 | 0 | 3 | 5 | 101 | 41 | 60 | 59% | 0-1 | 5.40 | 1.40 |
| 2001-04-08 | C.C. Sabathia | L | 21 | L 4-3 | vs BAL | 1 | 1 | - | 5.2 | 3 | 3 | 3 | 1 | 2 | 3 | 103 | 40 | 63 | 61% | 0-0 | 4.50 | 0.83 |
| 2001-04-09 | Chuck Finley | L | 38 | L 2-9 | @ CHA | 2 | 415 | L | 2.0 | 7 | 7 | 7 | 1 | 2 | 4 | 49 | 20 | 29 | 59% | 1-1 | 12.38 | 2.25 |
| 2001-04-10 | Tim Drew | R | 23 | L 7-8 | @ CHA | 1 | 4 | - | 3.2 | 6 | 5 | 3 | 1 | 2 | 3 | 83 | 36 | 47 | 57% | 0-0 | 6.75 | 2.00 |
| 2001-04-11 | Dave Burba | R | 35 | L 6-7 | @ CHA | 2 | 186 | L | 3.2 | 7 | 6 | 6 | 1 | 4 | 2 | 89 | 38 | 51 | 57% | 0-1 | 8.10 | 1.80 |
| 2001-04-12 | Bartolo Colon | R | 26 | W 5-3 | @ DET | 3 | 113 | W | 6.2 | 7 | 3 | 3 | 0 | 3 | 8 | 119 | 48 | 71 | 60% | 1-1 | 4.91 | 1.41 |
| 2001-04-13 | C.C. Sabathia | L | 21 | W 9-8 | @ DET | 2 | 2 | W | 5.0 | 5 | 4 | 4 | 0 | 2 | 2 | 88 | 36 | 52 | 59% | 1-0 | 5.73 | 1.09 |
| 2001-04-14 | Chuck Finley | L | 38 | L 0-1 | @ DET | 3 | 416 | L | 8.0 | 3 | 1 | 1 | 0 | 1 | 4 | 103 | 36 | 67 | 65% | 1-2 | 6.75 | 1.38 |
| 2001-04-17 | Dave Burba | R | 35 | W 8-1 | @ BAL | 3 | 187 | W | 6.0 | 4 | 1 | 1 | 1 | 3 | 4 | 110 | 48 | 62 | 56% | 1-1 | 5.63 | 1.56 |
| 2001-04-18 | Bartolo Colon | R | 26 | W 4-1 | @ BAL | 4 | 114 | W | 8.0 | 4 | 0 | 0 | 0 | 2 | 6 | 118 | 45 | 73 | 62% | 2-1 | 3.60 | 1.23 |
| 2001-04-19 | C.C. Sabathia | L | 21 | W 11-5 | @ BAL | 3 | 3 | W | 6.0 | 6 | 2 | 2 | 0 | 2 | 3 | 94 | 41 | 53 | 56% | 2-0 | 4.76 | 1.18 |
| 2001-04-20 | Chuck Finley | L | 38 | L 5-4 | vs DET | 4 | 417 | - | 6.0 | 8 | 4 | 4 | 2 | 1 | 4 | 92 | 33 | 59 | 64% | 1-2 | 6.55 | 1.41 |
| 2001-04-21 | Tim Drew | R | 23 | L 5-4 | vs DET | 2 | 5 | - | 7.0 | 4 | 3 | 2 | 1 | 2 | 3 | 102 | 45 | 57 | 56% | 0-0 | 4.09 | 1.27 |
| 2001-04-22 | Dave Burba | R | 35 | L 11-3 | vs DET | 4 | 188 | W | 5.0 | 6 | 3 | 3 | 1 | 2 | 4 | 99 | 38 | 61 | 62% | 2-1 | 5.57 | 1.57 |
| 2001-04-24 | Bartolo Colon | R | 26 | W 2-7 | vs ANA | 5 | 115 | L | 6.1 | 6 | 4 | 4 | 1 | 4 | 5 | 114 | 38 | 76 | 67% | 2-2 | 4.00 | 1.31 |
| 2001-04-25 | C.C. Sabathia | L | 21 | W 1-3 | vs ANA | 4 | 4 | L | 5.0 | 5 | 3 | 2 | 0 | 4 | 1 | 105 | 42 | 63 | 60% | 2-1 | 4.50 | 1.32 |
| 2001-04-26 | Chuck Finley | L | 38 | L 6-5 | vs ANA | 5 | 418 | - | 7.0 | 5 | 5 | 3 | 1 | 1 | 7 | 95 | 34 | 61 | 64% | 1-2 | 5.90 | 1.28 |
| 2001-04-27 | Tim Drew | R | 23 | W 9-11 | vs TEX | 3 | 6 | L | 3.0 | 6 | 6 | 6 | 2 | 2 | 1 | 50 | 18 | 32 | 64% | 0-1 | 7.07 | 1.57 |
| 2001-04-28 | Dave Burba | R | 35 | L 7-3 | vs TEX | 5 | 189 | W | 6.2 | 6 | 2 | 2 | 0 | 3 | 3 | 110 | 43 | 67 | 61% | 3-1 | 4.82 | 1.50 |
| 2001-04-29 | Bartolo Colon | R | 26 | L 9-2 | vs TEX | 6 | 116 | W | 8.0 | 5 | 2 | 1 | 0 | 2 | 10 | 132 | 51 | 81 | 61% | 3-2 | 3.48 | 1.23 |
| 2001-05-01 | Chuck Finley | L | 38 | W 13-2 | @ KCA | 6 | 419 | W | 7.0 | 6 | 2 | 1 | 0 | 1 | 3 | 102 | 36 | 66 | 65% | 2-2 | 5.00 | 1.22 |
| 2001-05-02 | C.C. Sabathia | L | 21 | W 8-4 | @ KCA | 5 | 5 | W | 5.0 | 4 | 1 | 1 | 1 | 1 | 2 | 73 | 24 | 49 | 67% | 3-1 | 4.00 | 1.26 |
| 2001-05-03 | Dave Burba | R | 35 | W 9-4 | @ KCA | 6 | 190 | W | 6.1 | 9 | 4 | 4 | 0 | 0 | 4 | 76 | 23 | 53 | 70% | 4-1 | 5.03 | 1.50 |
| 2001-05-04 | Bartolo Colon | R | 26 | W 8-6 | @ TBA | 7 | 117 | W | 6.2 | 8 | 2 | 2 | 1 | 4 | 7 | 118 | 52 | 66 | 56% | 4-2 | 3.35 | 1.29 |
| 2001-05-05 | Tim Drew | R | 23 | W 9-4 | @ TBA | 4 | 7 | - | 4.2 | 7 | 4 | 1 | 1 | 1 | 1 | 93 | 37 | 56 | 60% | 0-1 | 6.00 | 1.67 |
| 2001-05-06 | Chuck Finley | L | 38 | W 10-3 | @ TBA | 7 | 420 | W | 7.0 | 5 | 1 | 1 | 1 | 1 | 8 | 95 | 33 | 62 | 65% | 3-2 | 4.40 | 1.16 |
| 2001-05-08 | Dave Burba | R | 35 | L 8-4 | vs KCA | 7 | 191 | W | 7.0 | 8 | 4 | 4 | 0 | 1 | 7 | 110 | 37 | 73 | 66% | 5-1 | 5.05 | 1.46 |
| 2001-05-09 | C.C. Sabathia | L | 21 | L 5-1 | vs KCA | 6 | 6 | W | 5.2 | 5 | 1 | 1 | 0 | 1 | 5 | 94 | 33 | 61 | 65% | 4-1 | 3.66 | 1.25 |
| 2001-05-10 | Bartolo Colon | R | 26 | W 3-8 | vs KCA | 8 | 118 | L | 6.1 | 10 | 7 | 6 | 1 | 1 | 1 | 89 | 27 | 62 | 70% | 4-3 | 3.95 | 1.35 |
| 2001-05-11 | Tim Drew | R | 23 | L 10-6 | vs TBA | 5 | 8 | - | 3.0 | 6 | 4 | 4 | 2 | 1 | 1 | 56 | 23 | 33 | 59% | 0-1 | 6.86 | 1.76 |
| 2001-05-12 | Chuck Finley | L | 38 | L 8-0 | vs TBA | 8 | 421 | W | 7.0 | 7 | 0 | 0 | 0 | 1 | 11 | 113 | 45 | 68 | 60% | 4-2 | 3.78 | 1.16 |
| 2001-05-13 | Dave Burba | R | 35 | W 0-7 | vs TBA | 8 | 192 | L | 3.2 | 9 | 5 | 5 | 0 | 0 | 1 | 71 | 29 | 42 | 59% | 5-2 | 5.60 | 1.53 |
| 2001-05-15 | C.C. Sabathia | L | 21 | W 8-6 | @ TEX | 7 | 7 | W | 5.0 | 6 | 3 | 3 | 0 | 3 | 5 | 98 | 41 | 57 | 58% | 5-1 | 3.89 | 1.32 |
| 2001-05-16 | Bartolo Colon | R | 26 | W 4-3 | @ TEX | 9 | 119 | - | 7.1 | 5 | 3 | 3 | 1 | 2 | 10 | 120 | 44 | 76 | 63% | 4-3 | 3.94 | 1.31 |
| 2001-05-17 | Chuck Finley | L | 38 | L 7-12 | @ TEX | 9 | 422 | L | 1.0 | 9 | 8 | 8 | 1 | 0 | 2 | 41 | 11 | 30 | 73% | 4-3 | 5.12 | 1.31 |
| 2001-05-18 | Dave Burba | R | 35 | W 7-2 | @ ANA | 9 | 193 | W | 7.0 | 6 | 2 | 1 | 0 | 0 | 6 | 104 | 37 | 67 | 64% | 6-2 | 5.02 | 1.44 |
| 2001-05-19 | Jaret Wright | R | 25 | W 4-3 | @ ANA | 1 | 84 | - | 5.0 | 4 | 2 | 2 | 0 | 6 | 3 | 103 | 46 | 57 | 55% | 0-0 | 3.60 | 2.00 |
| 2001-05-20 | C.C. Sabathia | L | 21 | L 6-9 | @ ANA | 8 | 8 | - | 4.1 | 9 | 6 | 6 | 1 | 3 | 4 | 90 | 37 | 53 | 59% | 5-1 | 4.71 | 1.45 |
| 2001-05-22 | Bartolo Colon | R | 26 | W 0-3 | vs DET | 10 | 120 | L | 8.0 | 7 | 3 | 3 | 2 | 1 | 5 | 116 | 47 | 69 | 59% | 4-4 | 3.88 | 1.28 |
| 2001-05-23 | Chuck Finley | L | 38 | L 4-3 | vs DET | 10 | 423 | - | 6.2 | 7 | 3 | 3 | 1 | 1 | 8 | 99 | 34 | 65 | 66% | 4-3 | 4.97 | 1.29 |
| 2001-05-24 | Dave Burba | R | 35 | L 8-5 | vs DET | 10 | 194 | W | 5.2 | 10 | 4 | 4 | 0 | 3 | 4 | 102 | 42 | 60 | 59% | 7-2 | 5.12 | 1.52 |
| 2001-05-25 | Jaret Wright | R | 25 | L 6-4 | vs NYA | 2 | 85 | - | 4.2 | 6 | 3 | 3 | 0 | 5 | 3 | 81 | 36 | 45 | 56% | 0-0 | 4.50 | 2.10 |
| 2001-05-26 | C.C. Sabathia | L | 21 | W 5-12 | vs NYA | 9 | 9 | L | 4.2 | 7 | 5 | 5 | 2 | 4 | 3 | 115 | 42 | 73 | 63% | 5-2 | 5.28 | 1.57 |
| 2001-05-27 | Bartolo Colon | R | 26 | W 2-6 | vs NYA | 11 | 121 | L | 6.0 | 4 | 5 | 5 | 1 | 4 | 2 | 80 | 37 | 43 | 54% | 4-5 | 4.15 | 1.28 |
| 2001-05-28 | Chuck Finley | L | 39 | L 6-12 | @ DET | 11 | 424 | L | 1.0 | 8 | 8 | 8 | 2 | 2 | 1 | 44 | 15 | 29 | 66% | 4-4 | 6.10 | 1.44 |
| 2001-05-29 | Dave Burba | R | 35 | W 6-4 | @ DET | 11 | 195 | - | 5.0 | 8 | 4 | 4 | 1 | 4 | 3 | 106 | 49 | 57 | 54% | 7-2 | 5.29 | 1.59 |
| 2001-05-30 | Jaret Wright | R | 25 | W 8-4 | @ DET | 3 | 86 | W | 5.0 | 7 | 1 | 1 | 0 | 2 | 1 | 79 | 37 | 42 | 53% | 1-0 | 3.60 | 2.00 |
| 2001-06-01 | C.C. Sabathia | L | 21 | W 7-4 | @ NYA | 10 | 10 | W | 4.0 | 4 | 4 | 3 | 1 | 5 | 2 | 93 | 48 | 45 | 48% | 6-2 | 5.40 | 1.62 |
| 2001-06-02 | Bartolo Colon | R | 26 | L 4-9 | @ NYA | 12 | 122 | L | 5.0 | 7 | 5 | 5 | 2 | 2 | 4 | 90 | 39 | 51 | 57% | 4-6 | 4.45 | 1.31 |
| 2001-06-03 | Charles Nagy | R | 34 | W 4-3 | @ NYA | 1 | 278 | W | 7.0 | 4 | 1 | 1 | 1 | 3 | 1 | 93 | 36 | 57 | 61% | 1-0 | 1.29 | 1.00 |
| 2001-06-04 | Dave Burba | R | 35 | L 10-11 | @ MIN | 12 | 196 | - | 1.2 | 7 | 8 | 6 | 0 | 3 | 3 | 54 | 22 | 32 | 59% | 7-2 | 6.05 | 1.72 |
| 2001-06-05 | Jaret Wright | R | 25 | W 5-0 | @ MIN | 4 | 87 | W | 6.0 | 3 | 0 | 0 | 0 | 4 | 4 | 105 | 50 | 55 | 52% | 2-0 | 2.57 | 1.76 |
| 2001-06-06 | C.C. Sabathia | L | 21 | W 5-2 | @ MIN | 11 | 11 | - | 5.2 | 5 | 2 | 2 | 0 | 5 | 4 | 114 | 55 | 59 | 52% | 6-2 | 5.14 | 1.63 |
| 2001-06-07 | Bartolo Colon | R | 26 | W 6-2 | @ MIN | 13 | 123 | W | 6.0 | 6 | 2 | 2 | 0 | 1 | 8 | 92 | 30 | 62 | 67% | 5-6 | 4.35 | 1.30 |
| 2001-06-08 | Charles Nagy | R | 34 | W 4-7 | vs CIN | 2 | 279 | - | 5.1 | 6 | 3 | 3 | 0 | 2 | 3 | 80 | 33 | 47 | 59% | 1-0 | 3.00 | 1.25 |
| 2001-06-09 | Dave Burba | R | 35 | L 10-2 | vs CIN | 13 | 197 | W | 7.0 | 4 | 2 | 2 | 1 | 2 | 7 | 113 | 43 | 70 | 62% | 8-2 | 5.70 | 1.63 |
| 2001-06-10 | Jaret Wright | R | 25 | W 3-9 | vs CIN | 5 | 88 | L | 1.1 | 6 | 7 | 6 | 0 | 2 | 1 | 47 | 18 | 29 | 62% | 2-1 | 4.91 | 2.05 |
| 2001-06-12 | C.C. Sabathia | L | 21 | W 2-4 | vs MIL | 12 | 12 | - | 7.0 | 3 | 2 | 2 | 0 | 2 | 7 | 101 | 40 | 61 | 60% | 6-2 | 4.86 | 1.52 |
| 2001-06-13 | Bartolo Colon | R | 26 | L 5-2 | vs MIL | 14 | 124 | - | 7.0 | 6 | 2 | 2 | 1 | 3 | 6 | 120 | 48 | 72 | 60% | 5-6 | 4.22 | 1.30 |
| 2001-06-14 | Charles Nagy | R | 34 | W 4-9 | vs MIL | 3 | 280 | L | 5.0 | 10 | 6 | 6 | 3 | 0 | 4 | 79 | 28 | 51 | 65% | 1-1 | 5.29 | 1.47 |
| 2001-06-15 | Dave Burba | R | 35 | L 3-6 | @ PIT | 14 | 198 | L | 2.1 | 8 | 6 | 6 | 1 | 2 | 1 | 53 | 23 | 30 | 57% | 8-3 | 6.20 | 1.70 |
| 2001-06-16 | Jaret Wright | R | 25 | L 4-6 | @ PIT | 6 | 89 | L | 5.0 | 5 | 4 | 4 | 0 | 2 | 5 | 80 | 31 | 49 | 61% | 2-2 | 5.33 | 1.93 |
| 2001-06-17 | C.C. Sabathia | L | 21 | L 0-1 | @ PIT | 13 | 13 | - | 7.0 | 1 | 0 | 0 | 0 | 1 | 8 | 104 | 33 | 71 | 68% | 6-2 | 4.37 | 1.40 |
| 2001-06-19 | Bartolo Colon | R | 26 | W 9-10 | vs MIN | 15 | 125 | - | 4.1 | 9 | 6 | 4 | 2 | 2 | 4 | 89 | 36 | 53 | 60% | 5-6 | 4.37 | 1.35 |
| 2001-06-20 | Chuck Finley | L | 39 | L 4-2 | vs MIN | 12 | 425 | - | 4.2 | 4 | 2 | 2 | 0 | 3 | 4 | 86 | 39 | 47 | 55% | 4-4 | 5.91 | 1.44 |
| 2001-06-21 | Jaret Wright | R | 25 | L 9-6 | vs MIN | 7 | 90 | - | 2.0 | 5 | 5 | 5 | 2 | 1 | 1 | 35 | 12 | 23 | 66% | 2-2 | 6.52 | 2.00 |
| 2001-06-22 | C.C. Sabathia | L | 21 | W 6-5 | @ KCA | 14 | 14 | W | 6.0 | 5 | 4 | 3 | 1 | 2 | 6 | 104 | 38 | 66 | 63% | 7-2 | 4.38 | 1.38 |
| 2001-06-23 | Dave Burba | R | 35 | L 2-3 | @ KCA | 15 | 199 | L | 8.0 | 4 | 3 | 1 | 0 | 1 | 5 | 109 | 39 | 70 | 64% | 8-4 | 5.71 | 1.60 |
| 2001-06-24 | Bartolo Colon | R | 26 | W 4-2 | @ KCA | 16 | 126 | W | 6.0 | 4 | 2 | 2 | 1 | 4 | 9 | 117 | 51 | 66 | 56% | 6-6 | 4.29 | 1.35 |
| 2001-06-25 | Chuck Finley | L | 39 | L 7-8 | @ NYA | 13 | 426 | - | 3.1 | 11 | 6 | 6 | 1 | 1 | 1 | 76 | 29 | 47 | 62% | 4-4 | 6.45 | 1.55 |
| 2001-06-26 | Charles Nagy | R | 34 | W 5-3 | @ NYA | 4 | 281 | W | 5.1 | 8 | 2 | 2 | 0 | 0 | 3 | 76 | 28 | 48 | 63% | 2-2 | 5.25 | 1.50 |
| 2001-06-27 | C.C. Sabathia | L | 21 | L 5-15 | @ NYA | 15 | 15 | L | 1.0 | 3 | 6 | 4 | 0 | 3 | 1 | 46 | 19 | 27 | 59% | 7-3 | 4.79 | 1.44 |
| 2001-06-29 | Dave Burba | R | 35 | W 3-5 | vs KCA | 16 | 200 | L | 5.1 | 7 | 5 | 5 | 4 | 2 | 5 | 98 | 40 | 58 | 59% | 8-5 | 5.90 | 1.61 |
| 2001-06-30 | Bartolo Colon | R | 26 | W 7-11 | vs KCA | 17 | 127 | L | 3.2 | 9 | 9 | 9 | 4 | 1 | 1 | 67 | 27 | 40 | 60% | 6-7 | 4.91 | 1.40 |
| 2001-07-01 | Charles Nagy | R | 34 | W 11-13 | vs KCA | 5 | 282 | L | 1.0 | 8 | 7 | 7 | 1 | 1 | 1 | 38 | 15 | 23 | 61% | 2-3 | 7.56 | 1.80 |
| 2001-07-02 | C.C. Sabathia | L | 21 | L 2-1 | vs KCA | 16 | 16 | - | 7.0 | 3 | 0 | 0 | 0 | 3 | 8 | 119 | 52 | 67 | 56% | 7-3 | 4.39 | 1.39 |
| 2001-07-03 | Jake Westbrook | R | 24 | L 9-1 | vs BOS | 1 | 3 | W | 6.0 | 5 | 1 | 1 | 1 | 2 | 4 | 90 | 36 | 54 | 60% | 2-0 | 2.42 | 1.27 |
| 2001-07-04 | Dave Burba | R | 35 | W 4-13 | vs BOS | 17 | 201 | L | 3.2 | 11 | 8 | 8 | 1 | 1 | 2 | 67 | 19 | 48 | 72% | 8-6 | 6.43 | 1.67 |
| 2001-07-05 | Bartolo Colon | R | 26 | W 4-5 | vs BOS | 18 | 128 | - | 7.2 | 4 | 3 | 3 | 1 | 6 | 4 | 112 | 46 | 66 | 59% | 6-7 | 4.81 | 1.39 |
| 2001-07-06 | Charles Nagy | R | 34 | L 14-2 | vs SLN | 6 | 283 | W | 7.0 | 7 | 1 | 1 | 0 | 2 | 2 | 96 | 32 | 64 | 67% | 3-3 | 6.19 | 1.69 |
| 2001-07-07 | C.C. Sabathia | L | 21 | L 7-6 | vs SLN | 17 | 17 | - | 3.2 | 6 | 5 | 5 | 0 | 3 | 4 | 77 | 29 | 48 | 62% | 7-3 | 4.70 | 1.43 |
| 2001-07-08 | Jake Westbrook | R | 24 | W 3-4 | vs SLN | 2 | 4 | - | 5.0 | 5 | 3 | 3 | 1 | 1 | 2 | 82 | 29 | 53 | 65% | 2-0 | 2.90 | 1.26 |
| 2001-07-12 | Bartolo Colon | R | 26 | W 7-0 | @ CIN | 19 | 129 | W | 7.0 | 6 | 0 | 0 | 0 | 3 | 6 | 120 | 38 | 82 | 68% | 7-7 | 4.54 | 1.38 |
| 2001-07-13 | C.C. Sabathia | L | 21 | W 5-1 | @ CIN | 18 | 18 | W | 6.2 | 4 | 1 | 1 | 0 | 3 | 11 | 111 | 41 | 70 | 63% | 8-3 | 4.50 | 1.41 |
| 2001-07-14 | Dave Burba | R | 35 | L 5-6 | @ CIN | 18 | 202 | - | 6.1 | 6 | 3 | 2 | 1 | 3 | 7 | 117 | 45 | 72 | 62% | 8-6 | 6.22 | 1.66 |
| 2001-07-15 | Jake Westbrook | R | 24 | L 3-5 | @ HOU | 3 | 5 | L | 4.1 | 5 | 4 | 4 | 0 | 4 | 7 | 100 | 45 | 55 | 55% | 2-1 | 3.60 | 1.37 |
| 2001-07-16 | Charles Nagy | R | 34 | L 8-10 | @ HOU | 7 | 284 | - | 5.0 | 9 | 4 | 4 | 1 | 4 | 2 | 102 | 41 | 61 | 60% | 3-3 | 6.32 | 1.81 |
| 2001-07-17 | Bartolo Colon | R | 26 | W 10-4 | @ HOU | 20 | 130 | W | 5.0 | 1 | 0 | 0 | 0 | 1 | 4 | 65 | 23 | 42 | 65% | 8-7 | 4.36 | 1.35 |
| 2001-07-18 | C.C. Sabathia | L | 21 | W 9-4 | @ CHA | 19 | 19 | W | 5.2 | 4 | 2 | 2 | 0 | 4 | 7 | 105 | 37 | 68 | 65% | 9-3 | 4.41 | 1.41 |
| 2001-07-19 | Dave Burba | R | 35 | W 10-3 | @ CHA | 19 | 203 | W | 6.0 | 5 | 2 | 2 | 0 | 1 | 3 | 89 | 29 | 60 | 67% | 9-6 | 6.03 | 1.62 |
| 2001-07-20 | Jake Westbrook | R | 24 | W 3-7 | vs DET | 4 | 6 | L | 6.0 | 8 | 4 | 4 | 0 | 2 | 4 | 89 | 35 | 54 | 61% | 2-2 | 3.95 | 1.41 |
| 2001-07-21 | Charles Nagy | R | 34 | L 8-4 | vs DET | 8 | 285 | W | 7.0 | 5 | 3 | 3 | 1 | 1 | 3 | 81 | 27 | 54 | 67% | 4-3 | 5.93 | 1.66 |
| 2001-07-22 | Bartolo Colon | R | 26 | L 6-3 | vs DET | 21 | 131 | W | 5.0 | 7 | 2 | 2 | 0 | 4 | 5 | 108 | 43 | 65 | 60% | 9-7 | 4.33 | 1.38 |
| 2001-07-23 | C.C. Sabathia | L | 21 | L 2-0 | vs CHA | 20 | 20 | W | 6.0 | 2 | 0 | 0 | 0 | 5 | 5 | 115 | 47 | 68 | 59% | 10-3 | 4.16 | 1.40 |
| 2001-07-24 | Dave Burba | R | 35 | W 1-4 | vs CHA | 20 | 204 | L | 6.0 | 8 | 4 | 3 | 1 | 1 | 8 | 107 | 36 | 71 | 66% | 9-7 | 5.94 | 1.61 |
| 2001-07-25 | Jake Westbrook | R | 24 | L 7-5 | vs CHA | 5 | 7 | W | 5.0 | 8 | 4 | 4 | 1 | 2 | 3 | 75 | 27 | 48 | 64% | 3-2 | 4.30 | 1.48 |
| 2001-07-26 | Charles Nagy | R | 34 | W 4-5 | vs CHA | 9 | 286 | L | 7.0 | 10 | 5 | 4 | 1 | 0 | 3 | 100 | 31 | 69 | 69% | 4-4 | 5.82 | 1.63 |
| 2001-07-27 | Bartolo Colon | R | 26 | W 7-4 | @ DET | 22 | 132 | W | 6.1 | 9 | 4 | 4 | 1 | 2 | 5 | 107 | 42 | 65 | 61% | 10-7 | 4.40 | 1.40 |
| 2001-07-28 | C.C. Sabathia | L | 21 | W 6-4 | @ DET | 21 | 21 | - | 6.0 | 3 | 3 | 3 | 1 | 4 | 7 | 100 | 40 | 60 | 60% | 10-3 | 4.18 | 1.38 |
| 2001-07-28 | Steve Woodard | R | 26 | L 2-4 | @ DET | 1 | 85 | L | 5.2 | 8 | 4 | 4 | 0 | 1 | 2 | 80 | 28 | 52 | 65% | 1-1 | 4.50 | 1.48 |
| 2001-07-29 | Dave Burba | R | 35 | L 3-8 | @ DET | 21 | 205 | L | 3.2 | 7 | 6 | 6 | 1 | 3 | 2 | 88 | 38 | 50 | 57% | 9-8 | 6.21 | 1.65 |
| 2001-07-31 | Jake Westbrook | R | 24 | W 2-11 | vs OAK | 6 | 8 | L | 2.1 | 7 | 8 | 7 | 1 | 0 | 2 | 48 | 18 | 30 | 63% | 3-3 | 5.44 | 1.56 |
| 2001-08-01 | Charles Nagy | R | 34 | L 6-5 | vs OAK | 10 | 287 | - | 5.2 | 7 | 4 | 4 | 1 | 0 | 3 | 96 | 35 | 61 | 64% | 4-4 | 5.95 | 1.61 |
| 2001-08-02 | C.C. Sabathia | L | 21 | W 4-17 | vs OAK | 22 | 22 | L | 3.0 | 7 | 7 | 7 | 3 | 1 | 3 | 61 | 25 | 36 | 59% | 10-4 | 4.62 | 1.42 |
| 2001-08-03 | Bartolo Colon | R | 26 | W 1-2 | vs SEA | 23 | 133 | L | 9.0 | 4 | 2 | 2 | 0 | 4 | 10 | 128 | 53 | 75 | 59% | 10-8 | 4.26 | 1.37 |
| 2001-08-04 | Steve Woodard | R | 26 | W 5-8 | vs SEA | 2 | 86 | - | 3.2 | 9 | 3 | 2 | 0 | 1 | 4 | 73 | 24 | 49 | 67% | 1-1 | 4.42 | 1.55 |
| 2001-08-05 | Dave Burba | R | 35 | L 15-14 | vs SEA | 22 | 206 | - | 2.0 | 7 | 7 | 7 | 0 | 1 | 2 | 51 | 22 | 29 | 57% | 9-8 | 6.65 | 1.69 |
| 2001-08-06 | Charles Nagy | R | 34 | W 6-8 | vs SEA | 11 | 288 | L | 4.0 | 10 | 8 | 6 | 1 | 3 | 0 | 99 | 42 | 57 | 58% | 4-5 | 6.45 | 1.72 |
| 2001-08-07 | C.C. Sabathia | L | 21 | W 7-2 | @ MIN | 23 | 23 | W | 7.1 | 4 | 2 | 2 | 2 | 2 | 7 | 107 | 42 | 65 | 61% | 11-4 | 4.50 | 1.39 |
| 2001-08-08 | Bartolo Colon | R | 26 | W 8-2 | @ MIN | 24 | 134 | - | 7.0 | 10 | 2 | 2 | 0 | 2 | 10 | 140 | 50 | 90 | 64% | 10-8 | 4.18 | 1.38 |
| 2001-08-09 | Chuck Finley | L | 39 | L 4-6 | @ MIN | 14 | 427 | L | 4.0 | 3 | 4 | 3 | 0 | 4 | 3 | 86 | 37 | 49 | 57% | 4-5 | 6.46 | 1.56 |
| 2001-08-10 | Steve Woodard | R | 26 | L 2-7 | @ TEX | 3 | 87 | L | 6.0 | 6 | 4 | 4 | 0 | 0 | 3 | 75 | 25 | 50 | 67% | 1-2 | 4.58 | 1.49 |
| 2001-08-11 | Charles Nagy | R | 34 | L 5-6 | @ TEX | 12 | 289 | - | 5.2 | 7 | 2 | 2 | 0 | 1 | 1 | 84 | 32 | 52 | 62% | 4-5 | 6.14 | 1.68 |
| 2001-08-12 | C.C. Sabathia | L | 21 | W 13-2 | @ TEX | 24 | 24 | W | 6.0 | 3 | 2 | 2 | 0 | 4 | 7 | 108 | 41 | 67 | 62% | 12-4 | 4.43 | 1.38 |
| 2001-08-14 | Bartolo Colon | R | 26 | L 8-7 | vs MIN | 25 | 135 | - | 8.0 | 5 | 3 | 3 | 1 | 4 | 5 | 109 | 46 | 63 | 58% | 10-8 | 4.15 | 1.37 |
| 2001-08-15 | Chuck Finley | L | 39 | L 8-2 | vs MIN | 15 | 428 | W | 5.0 | 7 | 2 | 2 | 0 | 3 | 2 | 87 | 37 | 50 | 57% | 5-5 | 6.28 | 1.59 |
| 2001-08-16 | Steve Woodard | R | 26 | L 6-1 | vs MIN | 4 | 88 | W | 7.0 | 7 | 1 | 1 | 0 | 1 | 5 | 104 | 36 | 68 | 65% | 2-2 | 4.23 | 1.45 |
| 2001-08-17 | Charles Nagy | R | 34 | W 2-7 | vs ANA | 13 | 290 | L | 2.0 | 7 | 4 | 4 | 0 | 1 | 0 | 49 | 15 | 34 | 69% | 4-6 | 6.49 | 1.75 |
| 2001-08-18 | C.C. Sabathia | L | 21 | L 4-2 | vs ANA | 25 | 25 | W | 6.2 | 3 | 2 | 2 | 1 | 2 | 6 | 107 | 40 | 67 | 63% | 13-4 | 4.33 | 1.34 |
| 2001-08-19 | Bartolo Colon | R | 26 | W 1-4 | vs ANA | 26 | 136 | L | 7.0 | 7 | 4 | 4 | 2 | 1 | 6 | 107 | 38 | 69 | 64% | 10-9 | 4.19 | 1.36 |
| 2001-08-20 | Chuck Finley | L | 39 | L 0-9 | @ OAK | 16 | 429 | L | 5.0 | 7 | 5 | 5 | 0 | 2 | 3 | 90 | 41 | 49 | 54% | 5-6 | 6.44 | 1.60 |
| 2001-08-21 | Steve Woodard | R | 26 | W 2-1 | @ OAK | 5 | 89 | W | 7.0 | 5 | 1 | 1 | 0 | 0 | 1 | 114 | 39 | 75 | 66% | 3-2 | 3.95 | 1.38 |
| 2001-08-22 | Dave Burba | R | 35 | W 5-4 | @ OAK | 23 | 207 | - | 6.0 | 5 | 2 | 2 | 1 | 4 | 4 | 95 | 37 | 58 | 61% | 9-8 | 6.16 | 1.62 |
| 2001-08-23 | C.C. Sabathia | L | 21 | W 9-7 | @ OAK | 26 | 26 | - | 2.2 | 5 | 5 | 5 | 0 | 3 | 4 | 71 | 32 | 39 | 55% | 13-4 | 4.57 | 1.37 |
| 2001-08-24 | Bartolo Colon | R | 26 | L 1-4 | @ SEA | 27 | 137 | L | 7.1 | 9 | 4 | 4 | 1 | 1 | 8 | 127 | 50 | 77 | 61% | 10-10 | 4.20 | 1.36 |
| 2001-08-25 | Chuck Finley | L | 39 | L 2-3 | @ SEA | 17 | 430 | - | 2.0 | 0 | 0 | 0 | 0 | 2 | 2 | 35 | 14 | 21 | 60% | 5-6 | 6.29 | 1.59 |
| 2001-08-26 | Steve Woodard | R | 26 | W 4-3 | @ SEA | 6 | 90 | - | 7.2 | 7 | 3 | 3 | 1 | 2 | 4 | 120 | 45 | 75 | 63% | 3-2 | 3.89 | 1.36 |
| 2001-08-28 | Dave Burba | R | 35 | L 8-3 | vs BOS | 24 | 208 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 1 | 118 | 50 | 68 | 58% | 10-8 | 5.91 | 1.58 |
| 2001-08-29 | C.C. Sabathia | L | 21 | L 2-1 | vs BOS | 27 | 27 | W | 7.0 | 5 | 1 | 1 | 1 | 3 | 11 | 125 | 48 | 77 | 62% | 14-4 | 4.41 | 1.36 |
| 2001-08-30 | Bartolo Colon | R | 26 | L 3-1 | vs BOS | 28 | 138 | W | 6.0 | 8 | 1 | 1 | 0 | 2 | 5 | 111 | 38 | 73 | 66% | 11-10 | 4.11 | 1.37 |
| 2001-08-31 | Steve Woodard | R | 26 | L 8-11 | @ CHA | 7 | 91 | - | 3.2 | 8 | 7 | 7 | 2 | 0 | 1 | 76 | 26 | 50 | 66% | 3-2 | 4.50 | 1.40 |
| 2001-09-01 | Ryan Drese | R | 25 | W 4-3 | @ CHA | 1 | 1 | W | 5.2 | 6 | 2 | 2 | 0 | 2 | 2 | 105 | 43 | 62 | 59% | 1-0 | 3.27 | 1.36 |
| 2001-09-02 | Dave Burba | R | 35 | L 10-19 | @ CHA | 25 | 209 | L | 1.1 | 5 | 7 | 7 | 0 | 3 | 1 | 46 | 22 | 24 | 52% | 10-9 | 6.32 | 1.62 |
| 2001-09-03 | C.C. Sabathia | L | 21 | W 6-3 | @ CHA | 28 | 28 | W | 8.0 | 6 | 3 | 3 | 0 | 3 | 8 | 121 | 45 | 76 | 63% | 15-4 | 4.35 | 1.35 |
| 2001-09-04 | Bartolo Colon | R | 26 | W 8-5 | @ BOS | 29 | 139 | W | 5.2 | 10 | 4 | 4 | 0 | 3 | 3 | 106 | 38 | 68 | 64% | 12-10 | 4.19 | 1.40 |
| 2001-09-05 | Steve Woodard | R | 26 | L 7-10 | @ BOS | 8 | 92 | L | 1.2 | 8 | 5 | 5 | 0 | 1 | 1 | 63 | 24 | 39 | 62% | 3-3 | 4.92 | 1.48 |
| 2001-09-06 | Chuck Finley | L | 39 | W 6-4 | @ BOS | 18 | 431 | W | 6.1 | 4 | 2 | 2 | 0 | 1 | 3 | 78 | 32 | 46 | 59% | 6-6 | 6.07 | 1.54 |
| 2001-09-07 | Dave Burba | R | 35 | W 7-10 | vs CHA | 26 | 210 | L | 3.2 | 9 | 5 | 4 | 0 | 1 | 2 | 73 | 25 | 48 | 66% | 10-10 | 6.39 | 1.65 |
| 2001-09-08 | C.C. Sabathia | L | 21 | L 8-7 | vs CHA | 29 | 29 | - | 5.0 | 10 | 7 | 7 | 2 | 2 | 2 | 98 | 41 | 57 | 58% | 15-4 | 4.61 | 1.38 |
| 2001-09-09 | Steve Woodard | R | 26 | L 9-8 | vs CHA | 9 | 93 | - | 3.1 | 6 | 6 | 6 | 2 | 2 | 0 | 68 | 30 | 38 | 56% | 3-3 | 5.36 | 1.52 |
| 2001-09-10 | Bartolo Colon | R | 26 | W 1-7 | vs CHA | 30 | 140 | L | 5.1 | 7 | 3 | 3 | 1 | 3 | 4 | 130 | 54 | 76 | 58% | 12-11 | 4.20 | 1.41 |
| 2001-09-18 | Chuck Finley | L | 39 | L 11-2 | vs KCA | 19 | 432 | W | 6.0 | 5 | 1 | 0 | 0 | 1 | 5 | 97 | 38 | 59 | 61% | 7-6 | 5.68 | 1.51 |
| 2001-09-19 | Bartolo Colon | R | 26 | L 11-3 | vs KCA | 31 | 141 | W | 8.0 | 7 | 3 | 3 | 1 | 2 | 9 | 116 | 44 | 72 | 62% | 13-11 | 4.17 | 1.40 |
| 2001-09-20 | Ryan Drese | R | 25 | W 2-4 | vs KCA | 2 | 2 | L | 7.0 | 8 | 4 | 3 | 1 | 3 | 4 | 111 | 41 | 70 | 63% | 1-1 | 3.24 | 1.28 |
| 2001-09-21 | C.C. Sabathia | L | 21 | L 2-6 | @ MIN | 30 | 30 | L | 5.2 | 6 | 6 | 6 | 2 | 5 | 4 | 99 | 43 | 56 | 57% | 15-5 | 4.80 | 1.40 |
| 2001-09-22 | Steve Woodard | R | 26 | W 4-2 | @ MIN | 10 | 94 | - | 4.0 | 5 | 2 | 2 | 0 | 1 | 4 | 69 | 23 | 46 | 67% | 3-3 | 5.32 | 1.52 |
| 2001-09-23 | Chuck Finley | L | 39 | W 4-2 | @ MIN | 20 | 433 | W | 7.1 | 6 | 2 | 1 | 0 | 1 | 9 | 106 | 33 | 73 | 69% | 8-6 | 5.33 | 1.46 |
| 2001-09-24 | Bartolo Colon | R | 26 | W 2-3 | vs TOR | 32 | 142 | - | 8.1 | 6 | 1 | 1 | 0 | 2 | 8 | 128 | 51 | 77 | 60% | 13-11 | 4.06 | 1.38 |
| 2001-09-25 | Ryan Drese | R | 25 | L 11-7 | vs TOR | 3 | 3 | - | 6.0 | 7 | 4 | 4 | 0 | 2 | 5 | 99 | 38 | 61 | 62% | 1-1 | 3.77 | 1.32 |
| 2001-09-28 | C.C. Sabathia | L | 21 | W 0-1 | vs MIN | 31 | 31 | - | 7.0 | 4 | 0 | 0 | 0 | 4 | 11 | 122 | 49 | 73 | 60% | 15-5 | 4.61 | 1.39 |
| 2001-09-29 | Chuck Finley | L | 39 | L 9-8 | vs MIN | 21 | 434 | - | 6.0 | 6 | 5 | 4 | 1 | 2 | 4 | 98 | 36 | 62 | 63% | 8-6 | 5.37 | 1.45 |
| 2001-09-30 | Bartolo Colon | R | 26 | L 9-1 | vs MIN | 33 | 143 | W | 8.0 | 4 | 0 | 0 | 0 | 4 | 10 | 124 | 44 | 80 | 65% | 14-11 | 3.91 | 1.37 |
| 2001-10-02 | Ryan Drese | R | 25 | L 1-5 | @ KCA | 4 | 4 | - | 5.0 | 1 | 0 | 0 | 0 | 1 | 4 | 78 | 29 | 49 | 63% | 1-1 | 3.25 | 1.19 |
| 2001-10-03 | C.C. Sabathia | L | 21 | W 4-1 | @ KCA | 32 | 32 | W | 5.0 | 2 | 0 | 0 | 0 | 2 | 5 | 59 | 24 | 35 | 59% | 16-5 | 4.47 | 1.38 |
| 2001-10-04 | Bartolo Colon | R | 26 | L 4-8 | @ KCA | 34 | 144 | L | 1.1 | 4 | 6 | 5 | 0 | 4 | 2 | 54 | 24 | 30 | 56% | 14-12 | 4.09 | 1.40 |
| 2001-10-05 | Chuck Finley | L | 39 | L 0-5 | @ TOR | 22 | 435 | L | 5.0 | 6 | 5 | 5 | 1 | 2 | 2 | 79 | 31 | 48 | 61% | 8-7 | 5.53 | 1.46 |
| 2001-10-05 | Dave Burba | R | 35 | L 3-4 | @ TOR | 27 | 211 | - | 5.0 | 3 | 1 | 1 | 0 | 0 | 5 | 63 | 17 | 46 | 73% | 10-10 | 6.20 | 1.60 |
| 2001-10-06 | Tim Drew | R | 23 | L 2-5 | @ TOR | 6 | 9 | L | 4.1 | 5 | 4 | 3 | 1 | 2 | 4 | 81 | 37 | 44 | 54% | 0-2 | 7.97 | 1.91 |
| 2001-10-07 | C.C. Sabathia | L | 21 | W 3-2 | @ TOR | 33 | 33 | W | 5.0 | 1 | 1 | 1 | 0 | 2 | 5 | 72 | 25 | 47 | 65% | 17-5 | 4.40 | 1.36 |