| 2001-04-01 | vs TEX | 1 | W 8-1 | 1-0 | 1 | 19,891 | Esteban Loaiza | Rick Helling | Esteban Loaiza | Rick Helling | | 8 | 1 | 7 |
| 2001-04-03 | @ TBA | 2 | L 1-8 | 1-1 | 4 | 41,546 | Steve Parris | Albie Lopez | Albie Lopez | Steve Parris | | 9 | 9 | 0 |
| 2001-04-04 | @ TBA | 3 | W 11-8 | 2-1 | 2 | 15,172 | Joey Hamilton | Paul Wilson | Paul Quantrill | Ken Hill | Billy Koch | 20 | 17 | 3 |
| 2001-04-05 | @ TBA | 4 | W 11-0 | 3-1 | 2 | 14,023 | Chris Carpenter | Bryan Rekar | Chris Carpenter | Bryan Rekar | | 31 | 17 | 14 |
| 2001-04-06 | @ NYA | 5 | W 13-4 | 4-1 | 1 | 29,606 | Esteban Loaiza | Christian Parker | Esteban Loaiza | Christian Parker | | 44 | 21 | 23 |
| 2001-04-07 | @ NYA | 6 | W 3-2 | 5-1 | 1 | 30,487 | Chris Michalak | Orlando Hernandez | Chris Michalak | Orlando Hernandez | Billy Koch | 47 | 23 | 24 |
| 2001-04-08 | @ NYA | 7 | L 5-16 | 5-2 | 1 | 31,970 | Steve Parris | Roger Clemens | Roger Clemens | Steve Parris | | 52 | 39 | 13 |
| 2001-04-09 | vs TBA | 8 | W 8-1 | 6-2 | 1 | 48,115 | Joey Hamilton | Paul Wilson | Joey Hamilton | Paul Wilson | | 60 | 40 | 20 |
| 2001-04-10 | vs TBA | 9 | W 3-2 | 7-2 | 1 | 18,071 | Chris Carpenter | Bryan Rekar | Paul Quantrill | Tanyon Sturtze | | 63 | 42 | 21 |
| 2001-04-11 | vs TBA | 10 | L 3-4 | 7-3 | 2 | 24,017 | Esteban Loaiza | Ryan Rupe | Esteban Yan | Billy Koch | | 66 | 46 | 20 |
| 2001-04-13 | vs KCA | 11 | W 2-1 | 8-3 | 1 | 26,148 | Chris Michalak | Jeff Suppan | Chris Michalak | Jeff Suppan | Billy Koch | 68 | 47 | 21 |
| 2001-04-14 | vs KCA | 12 | W 5-4 | 9-3 | 1 | 26,024 | Joey Hamilton | Mac Suzuki | Bob File | Roberto Hernandez | | 73 | 51 | 22 |
| 2001-04-15 | vs KCA | 13 | L 2-4 | 9-4 | 1 | 21,379 | Chris Carpenter | Blake Stein | Blake Stein | Chris Carpenter | Roberto Hernandez | 75 | 55 | 20 |
| 2001-04-17 | vs NYA | 14 | W 6-5 | 10-4 | 2 | 20,019 | Esteban Loaiza | Randy Keisler | Esteban Loaiza | Randy Keisler | Billy Koch | 81 | 60 | 21 |
| 2001-04-18 | vs NYA | 15 | W 7-2 | 11-4 | 2 | 19,770 | Chris Michalak | Orlando Hernandez | Chris Michalak | Orlando Hernandez | | 88 | 62 | 26 |
| 2001-04-19 | vs NYA | 16 | L 5-6 | 11-5 | 2 | 24,684 | Joey Hamilton | Roger Clemens | Randy Choate | Bob File | Ramiro Mendoza | 93 | 68 | 25 |
| 2001-04-20 | @ KCA | 17 | W 12-4 | 12-5 | 2 | 28,018 | Chris Carpenter | Mac Suzuki | Chris Carpenter | Mac Suzuki | | 105 | 72 | 33 |
| 2001-04-21 | @ KCA | 18 | L 4-5 | 12-6 | 2 | 18,246 | Steve Parris | Blake Stein | Doug Henry | Dan Plesac | | 109 | 77 | 32 |
| 2001-04-22 | @ KCA | 19 | L 1-5 | 12-7 | 2 | 17,371 | Esteban Loaiza | Dan Reichert | Dan Reichert | Esteban Loaiza | Roberto Hernandez | 110 | 82 | 28 |
| 2001-04-24 | vs TEX | 20 | W 7-5 | 13-7 | 2 | 15,381 | Joey Hamilton | Doug Davis | John Frascatore | Pat Mahomes | Billy Koch | 117 | 87 | 30 |
| 2001-04-25 | vs TEX | 21 | W 8-5 | 14-7 | 2 | 15,021 | Chris Carpenter | Kenny Rogers | Paul Quantrill | Kenny Rogers | Billy Koch | 125 | 92 | 33 |
| 2001-04-27 | vs ANA | 22 | W 12-4 | 15-7 | 2 | 16,174 | Esteban Loaiza | Jarrod Washburn | Esteban Loaiza | Jarrod Washburn | | 137 | 96 | 41 |
| 2001-04-28 | vs ANA | 23 | L 1-4 | 15-8 | 2 | 19,261 | Chris Michalak | Ramon Ortiz | Ramon Ortiz | Chris Michalak | Troy Percival | 138 | 100 | 38 |
| 2001-04-29 | vs ANA | 24 | W 2-0 | 16-8 | 1 | 23,949 | Steve Parris | Scott Schoeneweis | Steve Parris | Scott Schoeneweis | Billy Koch | 140 | 100 | 40 |
| 2001-04-30 | vs KCA | 25 | L 3-6 | 16-9 | 2 | 13,766 | Joey Hamilton | Jeff Suppan | Jeff Suppan | Joey Hamilton | Roberto Hernandez | 143 | 106 | 37 |
| 2001-05-01 | @ OAK | 26 | W 5-4 | 17-9 | 2 | 10,935 | Chris Carpenter | Cory Lidle | Paul Quantrill | Jason Isringhausen | Billy Koch | 148 | 110 | 38 |
| 2001-05-02 | @ OAK | 27 | L 0-6 | 17-10 | 2 | 14,048 | Esteban Loaiza | Mark Mulder | Mark Mulder | Esteban Loaiza | | 148 | 116 | 32 |
| 2001-05-03 | @ OAK | 28 | L 2-3 | 17-11 | 2 | 10,586 | Chris Michalak | Tim Hudson | Chad Bradford | Pedro Borbon | | 150 | 119 | 31 |
| 2001-05-04 | @ SEA | 29 | W 8-3 | 18-11 | 1 | 42,284 | Steve Parris | Paul Abbott | Steve Parris | Paul Abbott | | 158 | 122 | 36 |
| 2001-05-05 | @ SEA | 30 | L 5-7 | 18-12 | 2 | 42,894 | Joey Hamilton | Freddy Garcia | Arthur Rhodes | Pedro Borbon | Kazuhiro Sasaki | 163 | 129 | 34 |
| 2001-05-06 | @ SEA | 31 | W 11-3 | 19-12 | 2 | 45,080 | Chris Carpenter | John Halama | Chris Carpenter | John Halama | | 174 | 132 | 42 |
| 2001-05-08 | vs OAK | 32 | L 5-8 | 19-13 | 2 | 16,479 | Esteban Loaiza | Mark Mulder | Mark Mulder | Esteban Loaiza | Jim Mecir | 179 | 140 | 39 |
| 2001-05-09 | vs OAK | 33 | L 5-8 | 19-14 | 3 | 16,241 | Chris Michalak | Tim Hudson | Tim Hudson | Chris Michalak | Jason Isringhausen | 184 | 148 | 36 |
| 2001-05-10 | vs OAK | 34 | L 8-14 | 19-15 | 3 | 16,130 | Steve Parris | Barry Zito | Mark Guthrie | Lance Painter | | 192 | 162 | 30 |
| 2001-05-11 | vs SEA | 35 | L 2-7 | 19-16 | 3 | 20,279 | Joey Hamilton | Paul Abbott | Paul Abbott | Joey Hamilton | | 194 | 169 | 25 |
| 2001-05-12 | vs SEA | 36 | L 7-11 | 19-17 | 3 | 24,908 | Chris Carpenter | Freddy Garcia | Brett Tomko | Kelvim Escobar | | 201 | 180 | 21 |
| 2001-05-13 | vs SEA | 37 | L 5-7 | 19-18 | 3 | 20,624 | Esteban Loaiza | Jamie Moyer | Jamie Moyer | Esteban Loaiza | Kazuhiro Sasaki | 206 | 187 | 19 |
| 2001-05-15 | @ ANA | 38 | W 9-3 | 20-18 | 3 | 15,904 | Chris Michalak | Ismael Valdez | Chris Michalak | Ismael Valdez | | 215 | 190 | 25 |
| 2001-05-16 | @ ANA | 39 | L 1-3 | 20-19 | 3 | 15,611 | Steve Parris | Scott Schoeneweis | Scott Schoeneweis | Steve Parris | Troy Percival | 216 | 193 | 23 |
| 2001-05-17 | @ ANA | 40 | L 2-4 | 20-20 | 3 | 15,204 | Joey Hamilton | Ramon Ortiz | Shigetoshi Hasegawa | Kelvim Escobar | Troy Percival | 218 | 197 | 21 |
| 2001-05-18 | @ TEX | 41 | W 9-3 | 21-20 | 3 | 35,368 | Chris Carpenter | Aaron Myette | Chris Carpenter | Aaron Myette | | 227 | 200 | 27 |
| 2001-05-19 | @ TEX | 42 | W 6-5 | 22-20 | 3 | 48,336 | Esteban Loaiza | Rick Helling | Paul Quantrill | Jeff Brantley | Billy Koch | 233 | 205 | 28 |
| 2001-05-20 | @ TEX | 43 | L 2-3 | 22-21 | 3 | 33,272 | Chris Michalak | Pat Mahomes | Pat Mahomes | Chris Michalak | Jeff Zimmerman | 235 | 208 | 27 |
| 2001-05-21 | vs CHA | 44 | W 10-3 | 23-21 | 3 | 20,806 | Steve Parris | Rocky Biddle | Steve Parris | Rocky Biddle | | 245 | 211 | 34 |
| 2001-05-23 | vs CHA | 45 | W 9-6 | 24-21 | 3 | 19,115 | Joey Hamilton | David Wells | Joey Hamilton | David Wells | Billy Koch | 254 | 217 | 37 |
| 2001-05-24 | vs CHA | 46 | L 1-3 | 24-22 | 3 | 17,062 | Chris Carpenter | Kip Wells | Kip Wells | Chris Carpenter | Keith Foulke | 255 | 220 | 35 |
| 2001-05-25 | @ BOS | 47 | L 0-4 | 24-23 | 3 | 32,912 | Esteban Loaiza | Hideo Nomo | Hideo Nomo | Esteban Loaiza | | 255 | 224 | 31 |
| 2001-05-26 | @ BOS | 48 | W 5-0 | 25-23 | 3 | 31,035 | Chris Michalak | Frank Castillo | Chris Michalak | Frank Castillo | | 260 | 224 | 36 |
| 2001-05-27 | @ BOS | 49 | L 2-4 | 25-24 | 3 | 31,420 | Steve Parris | Tim Wakefield | Tim Wakefield | Steve Parris | Derek Lowe | 262 | 228 | 34 |
| 2001-05-28 | @ CHA | 50 | L 3-6 | 25-25 | 3 | 20,631 | Joey Hamilton | Jon Garland | Jon Garland | Joey Hamilton | Bob Howry | 265 | 234 | 31 |
| 2001-05-29 | @ CHA | 51 | W 4-0 | 26-25 | 3 | 13,356 | Chris Carpenter | Kip Wells | Chris Carpenter | Kip Wells | | 269 | 234 | 35 |
| 2001-05-30 | @ CHA | 52 | L 3-4 | 26-26 | 3 | 13,208 | Esteban Loaiza | James Baldwin | Kelly Wunsch | Kelvim Escobar | Keith Foulke | 272 | 238 | 34 |
| 2001-05-31 | vs BOS | 53 | L 5-11 | 26-27 | 3 | 21,747 | Chris Michalak | Hideo Nomo | Rod Beck | Kelvim Escobar | | 277 | 249 | 28 |
| 2001-06-01 | vs BOS | 54 | L 4-6 | 26-28 | 3 | 21,564 | Steve Parris | Frank Castillo | Derek Lowe | Billy Koch | | 281 | 255 | 26 |
| 2001-06-02 | vs BOS | 55 | L 1-2 | 26-29 | 4 | 24,603 | Joey Hamilton | Tim Wakefield | Pete Schourek | Dan Plesac | Rod Beck | 282 | 257 | 25 |
| 2001-06-03 | vs BOS | 56 | L 4-5 | 26-30 | 4 | 24,653 | Chris Carpenter | David Cone | Hipolito Pichardo | Chris Carpenter | Derek Lowe | 286 | 262 | 24 |
| 2001-06-05 | vs TBA | 57 | W 13-1 | 27-30 | 4 | 15,078 | Esteban Loaiza | Albie Lopez | Esteban Loaiza | Albie Lopez | | 299 | 263 | 36 |
| 2001-06-06 | vs TBA | 58 | L 2-6 | 27-31 | 4 | 16,298 | Chris Michalak | Joe Kennedy | Joe Kennedy | Chris Michalak | | 301 | 269 | 32 |
| 2001-06-07 | vs TBA | 59 | W 8-7 | 28-31 | 3 | 26,835 | Steve Parris | Bryan Rekar | Pedro Borbon | Travis Phelps | | 309 | 276 | 33 |
| 2001-06-08 | vs FLO | 60 | W 7-6 | 29-31 | 3 | 18,629 | Joey Hamilton | Chuck Smith | Billy Koch | Ricky Bones | | 316 | 282 | 34 |
| 2001-06-09 | vs FLO | 61 | L 1-6 | 29-32 | 3 | 20,875 | Chris Carpenter | A.J. Burnett | A.J. Burnett | Chris Carpenter | | 317 | 288 | 29 |
| 2001-06-10 | vs FLO | 62 | L 2-7 | 29-33 | 4 | 20,070 | Esteban Loaiza | Brad Penny | Brad Penny | Esteban Loaiza | | 319 | 295 | 24 |
| 2001-06-11 | vs ATL | 63 | W 9-4 | 30-33 | 3 | 16,885 | Chris Michalak | John Burkett | Bob File | John Burkett | | 328 | 299 | 29 |
| 2001-06-12 | vs ATL | 64 | L 0-3 | 30-34 | 3 | 20,448 | Steve Parris | Odalis Perez | Odalis Perez | Steve Parris | John Rocker | 328 | 302 | 26 |
| 2001-06-13 | vs ATL | 65 | W 12-5 | 31-34 | 3 | 19,901 | Joey Hamilton | Tom Glavine | Joey Hamilton | Tom Glavine | | 340 | 307 | 33 |
| 2001-06-15 | @ MON | 66 | W 9-3 | 32-34 | 3 | 8,692 | Chris Carpenter | Javier Vazquez | Chris Carpenter | Javier Vazquez | | 349 | 310 | 39 |
| 2001-06-16 | @ MON | 67 | L 2-7 | 32-35 | 3 | 11,113 | Esteban Loaiza | Matt Blank | Matt Blank | Esteban Loaiza | | 351 | 317 | 34 |
| 2001-06-17 | @ MON | 68 | L 1-4 | 32-36 | 3 | 8,440 | Chris Michalak | Tony Armas | Guillermo Mota | Paul Quantrill | | 352 | 321 | 31 |
| 2001-06-18 | @ BAL | 69 | L 2-3 | 32-37 | 4 | 33,605 | Steve Parris | Sidney Ponson | Sidney Ponson | Pedro Borbon | Mike Trombley | 354 | 324 | 30 |
| 2001-06-19 | @ BAL | 70 | L 1-5 | 32-38 | 4 | 31,001 | Joey Hamilton | Josh Towers | Josh Towers | Joey Hamilton | Buddy Groom | 355 | 329 | 26 |
| 2001-06-20 | @ BAL | 71 | W 6-5 | 33-38 | 4 | 30,062 | Chris Carpenter | Willis Roberts | Paul Quantrill | Chuck McElroy | Billy Koch | 361 | 334 | 27 |
| 2001-06-22 | @ BOS | 72 | W 4-3 | 34-38 | 4 | 33,844 | Esteban Loaiza | Hideo Nomo | Pedro Borbon | Pete Schourek | Billy Koch | 365 | 337 | 28 |
| 2001-06-23 | @ BOS | 73 | W 9-6 | 35-38 | 3 | 33,266 | Chris Michalak | Frank Castillo | Bob File | Frank Castillo | Billy Koch | 374 | 343 | 31 |
| 2001-06-24 | @ BOS | 74 | W 5-2 | 36-38 | 3 | 32,804 | Steve Parris | Tim Wakefield | Dan Plesac | Tim Wakefield | Billy Koch | 379 | 345 | 34 |
| 2001-06-25 | vs BAL | 75 | L 2-8 | 36-39 | 3 | 18,243 | Joey Hamilton | Willis Roberts | Willis Roberts | Joey Hamilton | | 381 | 353 | 28 |
| 2001-06-26 | vs BAL | 76 | W 3-1 | 37-39 | 3 | 18,175 | Chris Carpenter | Jason Johnson | Chris Carpenter | Jason Johnson | Billy Koch | 384 | 354 | 30 |
| 2001-06-27 | vs BAL | 77 | L 3-7 | 37-40 | 3 | 17,517 | Esteban Loaiza | Jose Mercedes | Jose Mercedes | Esteban Loaiza | | 387 | 361 | 26 |
| 2001-06-28 | vs BAL | 78 | L 0-5 | 37-41 | 4 | 17,322 | Chris Michalak | Sidney Ponson | Sidney Ponson | Chris Michalak | | 387 | 366 | 21 |
| 2001-06-29 | vs BOS | 79 | W 8-4 | 38-41 | 4 | 23,055 | Steve Parris | Tim Wakefield | Paul Quantrill | Bryce Florie | | 395 | 370 | 25 |
| 2001-06-30 | vs BOS | 80 | L 5-7 | 38-42 | 4 | 28,543 | Joey Hamilton | David Cone | David Cone | Joey Hamilton | | 400 | 377 | 23 |
| 2001-07-01 | vs BOS | 81 | L 0-4 | 38-43 | 4 | 34,348 | Chris Carpenter | Rolando Arrojo | Rolando Arrojo | Chris Carpenter | | 400 | 381 | 19 |
| 2001-07-02 | vs BOS | 82 | L 4-16 | 38-44 | 4 | 38,237 | Esteban Loaiza | Hideo Nomo | Hideo Nomo | Esteban Loaiza | | 404 | 397 | 7 |
| 2001-07-03 | @ TBA | 83 | L 2-7 | 38-45 | 4 | 13,789 | Chris Michalak | Joe Kennedy | Joe Kennedy | Chris Michalak | Travis Phelps | 406 | 404 | 2 |
| 2001-07-04 | @ TBA | 84 | W 8-1 | 39-45 | 4 | 13,119 | Steve Parris | Bryan Rekar | Steve Parris | Bryan Rekar | | 414 | 405 | 9 |
| 2001-07-05 | @ TBA | 85 | W 7-4 | 40-45 | 3 | 10,706 | Joey Hamilton | Ryan Rupe | Joey Hamilton | Ryan Rupe | Billy Koch | 421 | 409 | 12 |
| 2001-07-06 | vs MON | 86 | L 7-10 | 40-46 | 3 | 20,074 | Chris Carpenter | Mike Thurman | Graeme Lloyd | Paul Quantrill | Ugueth Urbina | 428 | 419 | 9 |
| 2001-07-07 | vs MON | 87 | W 9-8 | 41-46 | 3 | 23,976 | Roy Halladay | Masato Yoshii | Dan Plesac | Scott Strickland | | 437 | 427 | 10 |
| 2001-07-08 | vs MON | 88 | W 9-3 | 42-46 | 3 | 31,012 | Chris Michalak | Tony Armas | Chris Michalak | Tony Armas | Paul Quantrill | 446 | 430 | 16 |
| 2001-07-12 | @ PHI | 89 | W 2-1 | 43-46 | 3 | 20,306 | Chris Carpenter | Dave Coggin | Kelvim Escobar | Jose Santiago | Billy Koch | 448 | 431 | 17 |
| 2001-07-13 | @ PHI | 90 | L 2-5 | 43-47 | 3 | 18,279 | Steve Parris | Omar Daal | Omar Daal | Dan Plesac | Jose Mesa | 450 | 436 | 14 |
| 2001-07-14 | @ PHI | 91 | W 4-2 | 44-47 | 3 | 22,418 | Joey Hamilton | Nelson Figueroa | Joey Hamilton | Nelson Figueroa | Billy Koch | 454 | 438 | 16 |
| 2001-07-15 | @ NYN | 92 | L 2-6 | 44-48 | 3 | 32,138 | Chris Michalak | Rick Reed | Rick Reed | Chris Michalak | | 456 | 444 | 12 |
| 2001-07-16 | @ NYN | 93 | L 0-3 | 44-49 | 3 | 34,203 | Roy Halladay | Steve Trachsel | Steve Trachsel | Roy Halladay | Armando Benitez | 456 | 447 | 9 |
| 2001-07-17 | @ NYN | 94 | L 0-1 | 44-50 | 3 | 26,630 | Chris Carpenter | Al Leiter | Al Leiter | Chris Carpenter | Armando Benitez | 456 | 448 | 8 |
| 2001-07-18 | vs BOS | 95 | L 4-5 | 44-51 | 3 | 30,449 | Steve Parris | David Cone | Rich Garces | Billy Koch | Derek Lowe | 460 | 453 | 7 |
| 2001-07-19 | vs BOS | 96 | W 4-3 | 45-51 | 3 | 30,488 | Joey Hamilton | Rolando Arrojo | Kelvim Escobar | Derek Lowe | | 464 | 456 | 8 |
| 2001-07-20 | @ NYA | 97 | W 10-4 | 46-51 | 3 | 46,634 | Esteban Loaiza | Brett Jodie | Esteban Loaiza | Brett Jodie | | 474 | 460 | 14 |
| 2001-07-21 | @ NYA | 98 | W 5-3 | 47-51 | 3 | 55,264 | Roy Halladay | Randy Keisler | Paul Quantrill | Mariano Rivera | Billy Koch | 479 | 463 | 16 |
| 2001-07-22 | @ NYA | 99 | L 3-7 | 47-52 | 3 | 51,132 | Chris Carpenter | Mike Mussina | Mike Mussina | Chris Carpenter | | 482 | 470 | 12 |
| 2001-07-23 | @ NYA | 100 | L 2-7 | 47-53 | 3 | 38,573 | Steve Parris | Roger Clemens | Roger Clemens | Steve Parris | | 484 | 477 | 7 |
| 2001-07-24 | @ BOS | 101 | L 4-6 | 47-54 | 3 | 33,154 | Joey Hamilton | David Cone | David Cone | Joey Hamilton | Derek Lowe | 488 | 483 | 5 |
| 2001-07-25 | @ BOS | 102 | W 4-3 | 48-54 | 3 | 33,030 | Esteban Loaiza | Rolando Arrojo | Paul Quantrill | Derek Lowe | Billy Koch | 492 | 486 | 6 |
| 2001-07-26 | @ BOS | 103 | L 3-6 | 48-55 | 3 | 33,094 | Roy Halladay | Hideo Nomo | Hideo Nomo | Bob File | Rod Beck | 495 | 492 | 3 |
| 2001-07-27 | vs NYA | 104 | L 1-9 | 48-56 | 3 | 36,666 | Chris Carpenter | Mike Mussina | Mike Mussina | Chris Carpenter | | 496 | 501 | -5 |
| 2001-07-28 | vs NYA | 105 | L 1-12 | 48-57 | 3 | 44,105 | Kelvim Escobar | Roger Clemens | Roger Clemens | Kelvim Escobar | | 497 | 513 | -16 |
| 2001-07-29 | vs NYA | 106 | L 3-9 | 48-58 | 3 | 40,149 | Joey Hamilton | Andy Pettitte | Andy Pettitte | Joey Hamilton | | 500 | 522 | -22 |
| 2001-07-31 | vs MIN | 107 | W 3-1 | 49-58 | 3 | 23,849 | Esteban Loaiza | Joe Mays | Esteban Loaiza | Joe Mays | Billy Koch | 503 | 523 | -20 |
| 2001-08-01 | vs MIN | 108 | W 3-1 | 50-58 | 3 | 26,069 | Roy Halladay | Kyle Lohse | Roy Halladay | Kyle Lohse | Billy Koch | 506 | 524 | -18 |
| 2001-08-02 | vs MIN | 109 | L 4-9 | 50-59 | 3 | 26,849 | Chris Carpenter | Rick Reed | Rick Reed | Chris Carpenter | | 510 | 533 | -23 |
| 2001-08-03 | vs BAL | 110 | W 10-1 | 51-59 | 3 | 20,115 | Kelvim Escobar | Jose Mercedes | Kelvim Escobar | Jose Mercedes | | 520 | 534 | -14 |
| 2001-08-04 | vs BAL | 111 | W 2-1 | 52-59 | 3 | 22,322 | Brandon Lyon | Sidney Ponson | Brandon Lyon | Sidney Ponson | Billy Koch | 522 | 535 | -13 |
| 2001-08-05 | vs BAL | 112 | W 5-4 | 53-59 | 3 | 27,724 | Esteban Loaiza | Josh Towers | Esteban Loaiza | Josh Towers | Billy Koch | 527 | 539 | -12 |
| 2001-08-07 | @ SEA | 113 | L 4-5 | 53-60 | 3 | 45,636 | Roy Halladay | Joel Pineiro | John Halama | Matt DeWitt | | 531 | 544 | -13 |
| 2001-08-08 | @ SEA | 114 | L 4-12 | 53-61 | 3 | 45,450 | Chris Carpenter | Jamie Moyer | Jamie Moyer | Chris Carpenter | | 535 | 556 | -21 |
| 2001-08-09 | @ SEA | 115 | W 6-5 | 54-61 | 3 | 45,670 | Kelvim Escobar | Freddy Garcia | Paul Quantrill | Freddy Garcia | Billy Koch | 541 | 561 | -20 |
| 2001-08-10 | @ ANA | 116 | L 7-8 | 54-62 | 3 | 30,484 | Brandon Lyon | Scott Schoeneweis | Scott Schoeneweis | Brandon Lyon | Troy Percival | 548 | 569 | -21 |
| 2001-08-11 | @ ANA | 117 | W 7-6 | 55-62 | 3 | 27,927 | Esteban Loaiza | Ramon Ortiz | Dan Plesac | Al Levine | Billy Koch | 555 | 575 | -20 |
| 2001-08-12 | @ ANA | 118 | L 5-6 | 55-63 | 3 | 19,129 | Roy Halladay | Pat Rapp | Al Levine | Dan Plesac | Troy Percival | 560 | 581 | -21 |
| 2001-08-14 | vs OAK | 119 | W 6-3 | 56-63 | 3 | 25,121 | Chris Carpenter | Tim Hudson | Billy Koch | Jason Isringhausen | | 566 | 584 | -18 |
| 2001-08-15 | vs OAK | 120 | W 5-2 | 57-63 | 3 | 23,135 | Kelvim Escobar | Barry Zito | Kelvim Escobar | Barry Zito | Billy Koch | 571 | 586 | -15 |
| 2001-08-16 | vs OAK | 121 | L 4-8 | 57-64 | 3 | 30,062 | Brandon Lyon | Cory Lidle | Cory Lidle | Brandon Lyon | | 575 | 594 | -19 |
| 2001-08-17 | vs TEX | 122 | W 11-3 | 58-64 | 3 | 22,384 | Esteban Loaiza | Darren Oliver | Esteban Loaiza | Darren Oliver | | 586 | 597 | -11 |
| 2001-08-18 | vs TEX | 123 | L 5-12 | 58-65 | 3 | 26,092 | Roy Halladay | Rob Bell | Juan Moreno | Billy Koch | | 591 | 609 | -18 |
| 2001-08-19 | vs TEX | 124 | L 4-8 | 58-66 | 3 | 30,336 | Chris Carpenter | Aaron Myette | Aaron Myette | Chris Carpenter | | 595 | 617 | -22 |
| 2001-08-20 | @ MIN | 125 | W 3-2 | 59-66 | 3 | 16,032 | Kelvim Escobar | Joe Mays | Kelvim Escobar | Joe Mays | Billy Koch | 598 | 619 | -21 |
| 2001-08-21 | @ MIN | 126 | W 7-5 | 60-66 | 3 | 13,023 | Brandon Lyon | Brad Radke | Brandon Lyon | Jack Cressend | Billy Koch | 605 | 624 | -19 |
| 2001-08-22 | @ MIN | 127 | L 3-6 | 60-67 | 3 | 15,303 | Esteban Loaiza | Rick Reed | Rick Reed | Esteban Loaiza | | 608 | 630 | -22 |
| 2001-08-23 | @ MIN | 128 | W 6-2 | 61-67 | 3 | 16,482 | Roy Halladay | Kyle Lohse | Roy Halladay | Kyle Lohse | | 614 | 632 | -18 |
| 2001-08-24 | @ BAL | 129 | W 5-0 | 62-67 | 3 | 43,606 | Chris Carpenter | Jason Johnson | Chris Carpenter | Jason Johnson | | 619 | 632 | -13 |
| 2001-08-25 | @ BAL | 130 | W 9-0 | 63-67 | 3 | 42,260 | Kelvim Escobar | Calvin Maduro | Kelvim Escobar | Calvin Maduro | | 628 | 632 | -4 |
| 2001-08-26 | @ BAL | 131 | W 5-1 | 64-67 | 3 | 37,994 | Brandon Lyon | Jose Mercedes | Brandon Lyon | Jose Mercedes | | 633 | 633 | 0 |
| 2001-08-28 | @ NYA | 132 | L 0-4 | 64-68 | 3 | 37,450 | Esteban Loaiza | Mike Mussina | Mike Mussina | Esteban Loaiza | Mariano Rivera | 633 | 637 | -4 |
| 2001-08-29 | @ NYA | 133 | W 3-2 | 65-68 | 3 | 36,855 | Roy Halladay | Sterling Hitchcock | Roy Halladay | Sterling Hitchcock | Billy Koch | 636 | 639 | -3 |
| 2001-08-30 | @ NYA | 134 | L 4-5 | 65-69 | 3 | 42,537 | Chris Carpenter | Andy Pettitte | Jay Witasick | Scott Eyre | | 640 | 644 | -4 |
| 2001-08-31 | vs DET | 135 | L 3-4 | 65-70 | 3 | 22,383 | Kelvim Escobar | Steve Sparks | Steve Sparks | Pedro Borbon | Matt Anderson | 643 | 648 | -5 |
| 2001-09-01 | vs DET | 136 | W 3-1 | 66-70 | 3 | 22,052 | Brandon Lyon | Jeff Weaver | Brandon Lyon | Jeff Weaver | Dan Plesac | 646 | 649 | -3 |
| 2001-09-02 | vs DET | 137 | W 11-0 | 67-70 | 3 | 24,146 | Esteban Loaiza | Jose Lima | Esteban Loaiza | Jose Lima | | 657 | 649 | 8 |
| 2001-09-03 | vs NYA | 138 | L 5-7 | 67-71 | 3 | 28,404 | Roy Halladay | Sterling Hitchcock | Mark Wohlers | Billy Koch | Ramiro Mendoza | 662 | 656 | 6 |
| 2001-09-04 | vs NYA | 139 | W 14-0 | 68-71 | 3 | 20,036 | Chris Carpenter | Andy Pettitte | Chris Carpenter | Andy Pettitte | | 676 | 656 | 20 |
| 2001-09-05 | vs NYA | 140 | L 3-4 | 68-72 | 3 | 29,235 | Kelvim Escobar | Roger Clemens | Roger Clemens | Kelvim Escobar | Mariano Rivera | 679 | 660 | 19 |
| 2001-09-07 | @ DET | 141 | W 2-1 | 69-72 | 3 | 28,083 | Brandon Lyon | Jose Lima | Brandon Lyon | Jose Lima | Billy Koch | 681 | 661 | 20 |
| 2001-09-08 | @ DET | 142 | L 3-4 | 69-73 | 3 | 29,158 | Roy Halladay | Heath Murray | Heath Murray | Roy Halladay | Matt Anderson | 684 | 665 | 19 |
| 2001-09-09 | @ DET | 143 | W 6-3 | 70-73 | 3 | 24,652 | Chris Carpenter | Nate Cornejo | Chris Carpenter | Nate Cornejo | | 690 | 668 | 22 |
| 2001-09-18 | vs BAL | 144 | W 8-5 | 71-73 | 3 | 18,604 | Kelvim Escobar | Jason Johnson | Dan Plesac | Jorge Julio | Billy Koch | 698 | 673 | 25 |
| 2001-09-19 | vs BAL | 145 | W 4-1 | 72-73 | 3 | 31,303 | Roy Halladay | Calvin Maduro | Roy Halladay | Calvin Maduro | Billy Koch | 702 | 674 | 28 |
| 2001-09-20 | vs BAL | 146 | L 6-12 | 72-74 | 3 | 21,895 | Chris Carpenter | Josh Towers | John Parrish | Bob File | | 708 | 686 | 22 |
| 2001-09-21 | vs TBA | 147 | L 4-7 | 72-75 | 3 | 25,344 | Brandon Lyon | Bryan Rekar | Bryan Rekar | Brandon Lyon | Esteban Yan | 712 | 693 | 19 |
| 2001-09-22 | vs TBA | 148 | W 8-7 | 73-75 | 3 | 24,691 | Esteban Loaiza | Nick Bierbrodt | Pasqual Coco | Jesus Colome | Billy Koch | 720 | 700 | 20 |
| 2001-09-23 | vs TBA | 149 | L 0-1 | 73-76 | 3 | 31,351 | Kelvim Escobar | Joe Kennedy | Joe Kennedy | Kelvim Escobar | Esteban Yan | 720 | 701 | 19 |
| 2001-09-24 | @ CLE | 150 | W 3-2 | 74-76 | 3 | 32,425 | Roy Halladay | Bartolo Colon | Bob File | Danys Baez | Scott Eyre | 723 | 703 | 20 |
| 2001-09-25 | @ CLE | 151 | L 7-11 | 74-77 | 3 | 35,729 | Chris Carpenter | Ryan Drese | David Riske | Dan Plesac | | 730 | 714 | 16 |
| 2001-09-27 | @ TBA | 152 | L 1-5 | 74-78 | 3 | 13,045 | Brandon Lyon | Ryan Rupe | Jesus Colome | Scott Eyre | | 731 | 719 | 12 |
| 2001-09-28 | @ TBA | 153 | L 1-6 | 74-79 | 3 | 10,586 | Kelvim Escobar | Bryan Rekar | Bryan Rekar | Kelvim Escobar | Travis Phelps | 732 | 725 | 7 |
| 2001-09-29 | @ TBA | 154 | L 2-5 | 74-80 | 3 | 17,635 | Roy Halladay | Nick Bierbrodt | Nick Bierbrodt | Roy Halladay | Esteban Yan | 734 | 730 | 4 |
| 2001-09-30 | @ TBA | 155 | W 6-5 | 75-80 | 3 | 14,217 | Chris Carpenter | Joe Kennedy | Paul Quantrill | Doug Creek | Scott Eyre | 740 | 735 | 5 |
| 2001-10-01 | @ BAL | 156 | W 1-0 | 76-80 | 3 | 37,108 | Esteban Loaiza | Rick Bauer | Esteban Loaiza | Rick Bauer | Billy Koch | 741 | 735 | 6 |
| 2001-10-02 | @ BAL | 157 | L 3-4 | 76-81 | 3 | 29,390 | Brandon Lyon | Sean Douglass | Willis Roberts | Matt DeWitt | | 744 | 739 | 5 |
| 2001-10-03 | @ BAL | 158 | W 7-6 | 77-81 | 3 | 33,705 | Pasqual Coco | Jason Johnson | Scott Eyre | Buddy Groom | Billy Koch | 751 | 745 | 6 |
| 2001-10-05 | vs CLE | 159 | W 5-0 | 79-81 | 3 | 0 | Roy Halladay | Chuck Finley | Roy Halladay | Chuck Finley | | 756 | 745 | 11 |
| 2001-10-05 | vs CLE | 160 | W 4-3 | 79-81 | 3 | 19,387 | Esteban Loaiza | Dave Burba | Bob File | Ryan Drese | | 760 | 748 | 12 |
| 2001-10-06 | vs CLE | 161 | W 5-2 | 80-81 | 3 | 20,762 | Chris Carpenter | Tim Drew | Chris Carpenter | Tim Drew | Paul Quantrill | 765 | 750 | 15 |
| 2001-10-07 | vs CLE | 162 | L 2-3 | 80-82 | 3 | 28,217 | Brandon Lyon | CC Sabathia | CC Sabathia | Brandon Lyon | John Rocker | 767 | 753 | 14 |