| 2001-04-02 | @ LAN | 1 | L 0-1 | 0-1 | 4 | 53,154 | Jamey Wright | Chan Ho Park | Chan Ho Park | Jamey Wright | Jeff Shaw | 0 | 1 | -1 |
| 2001-04-03 | @ HOU | 2 | L 3-11 | 0-2 | 4 | 36,526 | Jimmy Haynes | Scott Elarton | Scott Elarton | Jimmy Haynes | | 3 | 12 | -9 |
| 2001-04-04 | @ HOU | 3 | L 6-8 | 0-3 | 5 | 25,092 | Paul Rigdon | Jose Lima | Jay Powell | Curt Leskanic | | 9 | 20 | -11 |
| 2001-04-05 | @ HOU | 4 | L 2-8 | 0-4 | 5 | 24,055 | Ben Sheets | Wade Miller | Wade Miller | Ben Sheets | | 11 | 28 | -17 |
| 2001-04-06 | vs CIN | 5 | W 5-4 | 1-4 | 6 | 42,024 | Jeff D'Amico | Rob Bell | David Weathers | Dennys Reyes | | 16 | 32 | -16 |
| 2001-04-07 | vs CIN | 6 | W 6-1 | 2-4 | 6 | 40,651 | Jamey Wright | Pete Harnisch | Jamey Wright | Pete Harnisch | | 22 | 33 | -11 |
| 2001-04-08 | vs CIN | 7 | W 8-4 | 3-4 | 5 | 34,077 | Jimmy Haynes | Osvaldo Fernandez | Jimmy Haynes | Osvaldo Fernandez | | 30 | 37 | -7 |
| 2001-04-10 | vs HOU | 8 | L 0-3 | 3-5 | 6 | 23,577 | Paul Rigdon | Jose Lima | Jose Lima | Curt Leskanic | Billy Wagner | 30 | 40 | -10 |
| 2001-04-11 | vs HOU | 9 | L 1-7 | 3-6 | 6 | 26,021 | Ben Sheets | Wade Miller | Wade Miller | Ben Sheets | | 31 | 47 | -16 |
| 2001-04-12 | vs HOU | 10 | W 12-4 | 4-6 | 6 | 23,599 | Jeff D'Amico | Octavio Dotel | Jeff D'Amico | Octavio Dotel | | 43 | 51 | -8 |
| 2001-04-13 | vs SFN | 11 | L 3-7 | 4-7 | 6 | 34,998 | Jamey Wright | Kirk Rueter | Kirk Rueter | Jamey Wright | | 46 | 58 | -12 |
| 2001-04-14 | vs SFN | 12 | W 11-6 | 5-7 | 5 | 42,080 | Jimmy Haynes | Mark Gardner | Mike DeJean | Mark Gardner | | 57 | 64 | -7 |
| 2001-04-15 | vs SFN | 13 | W 7-4 | 6-7 | 5 | 25,981 | Paul Rigdon | Russ Ortiz | Paul Rigdon | Russ Ortiz | Curt Leskanic | 64 | 68 | -4 |
| 2001-04-17 | @ CIN | 14 | L 2-3 | 6-8 | 4 | 15,729 | Jeff D'Amico | Elmer Dessens | Scott Sullivan | Will Cunnane | Danny Graves | 66 | 71 | -5 |
| 2001-04-18 | @ CIN | 15 | W 7-4 | 7-8 | 4 | 16,837 | Jamey Wright | Pete Harnisch | Jamey Wright | Pete Harnisch | David Weathers | 73 | 75 | -2 |
| 2001-04-20 | @ SFN | 16 | L 1-3 | 7-9 | 4 | 41,059 | Jimmy Haynes | Russ Ortiz | Russ Ortiz | Jimmy Haynes | Robb Nen | 74 | 78 | -4 |
| 2001-04-21 | @ SFN | 17 | W 6-3 | 8-9 | 4 | 41,059 | Paul Rigdon | Mark Gardner | Paul Rigdon | Mark Gardner | David Weathers | 80 | 81 | -1 |
| 2001-04-22 | @ SFN | 18 | L 4-6 | 8-10 | 4 | 41,059 | Jeff D'Amico | Shawn Estes | Shawn Estes | Jeff D'Amico | Robb Nen | 84 | 87 | -3 |
| 2001-04-24 | vs NYN | 19 | W 6-4 | 9-10 | 4 | 27,404 | Jamey Wright | Glendon Rusch | Mike DeJean | Donne Wall | Curt Leskanic | 90 | 91 | -1 |
| 2001-04-25 | vs NYN | 20 | W 7-2 | 10-10 | 4 | 30,353 | Jimmy Haynes | Steve Trachsel | Jimmy Haynes | Steve Trachsel | David Weathers | 97 | 93 | 4 |
| 2001-04-26 | vs NYN | 21 | W 12-8 | 11-10 | 4 | 25,233 | Paul Rigdon | Brett Hinchliffe | Chad Fox | Brett Hinchliffe | | 109 | 101 | 8 |
| 2001-04-27 | vs MON | 22 | L 1-6 | 11-11 | 4 | 26,350 | Mark Leiter | Mike Thurman | Mike Thurman | Mark Leiter | | 110 | 107 | 3 |
| 2001-04-28 | vs MON | 23 | W 8-4 | 12-11 | 4 | 40,877 | Ben Sheets | Chris Peters | Ben Sheets | Chris Peters | | 118 | 111 | 7 |
| 2001-04-29 | vs MON | 24 | W 10-0 | 13-11 | 3 | 32,700 | Jamey Wright | Javier Vazquez | Jamey Wright | Javier Vazquez | | 128 | 111 | 17 |
| 2001-05-01 | @ ATL | 25 | W 5-3 | 14-11 | 3 | 24,922 | Jimmy Haynes | Kevin Millwood | Jimmy Haynes | Kevin Millwood | Curt Leskanic | 133 | 114 | 19 |
| 2001-05-02 | @ ATL | 26 | L 0-1 | 14-12 | 3 | 24,802 | Paul Rigdon | Greg Maddux | Greg Maddux | Paul Rigdon | | 133 | 115 | 18 |
| 2001-05-03 | @ ATL | 27 | W 5-0 | 15-12 | 3 | 26,411 | Ben Sheets | John Burkett | Ben Sheets | John Burkett | | 138 | 115 | 23 |
| 2001-05-04 | @ FLO | 28 | L 6-9 | 15-13 | 3 | 11,108 | Jamey Wright | Ryan Dempster | Ryan Dempster | Jamey Wright | Antonio Alfonseca | 144 | 124 | 20 |
| 2001-05-05 | @ FLO | 29 | W 8-2 | 16-13 | 2 | 17,253 | Mark Leiter | Matt Clement | Mark Leiter | Matt Clement | | 152 | 126 | 26 |
| 2001-05-06 | @ FLO | 30 | L 1-5 | 16-14 | 3 | 10,095 | Jimmy Haynes | Chuck Smith | Chuck Smith | Jimmy Haynes | | 153 | 131 | 22 |
| 2001-05-07 | vs CHN | 31 | L 6-7 | 16-15 | 4 | 30,239 | Paul Rigdon | Jon Lieber | Todd Van Poppel | David Weathers | Tom Gordon | 159 | 138 | 21 |
| 2001-05-08 | vs CHN | 32 | W 4-1 | 17-15 | 2 | 26,751 | Ben Sheets | Kerry Wood | Ben Sheets | Kerry Wood | Curt Leskanic | 163 | 139 | 24 |
| 2001-05-09 | vs CHN | 33 | L 3-6 | 17-16 | 4 | 30,616 | Jamey Wright | Kevin Tapani | Kevin Tapani | Jamey Wright | Tom Gordon | 166 | 145 | 21 |
| 2001-05-10 | vs CHN | 34 | W 11-1 | 18-16 | 4 | 36,149 | Mark Leiter | Julian Tavarez | Allen Levrault | Julian Tavarez | Mike DeJean | 177 | 146 | 31 |
| 2001-05-11 | vs PIT | 35 | L 0-3 | 18-17 | 4 | 31,525 | Jimmy Haynes | Jason Schmidt | Jason Schmidt | Jimmy Haynes | Mike Williams | 177 | 149 | 28 |
| 2001-05-12 | vs PIT | 36 | W 5-4 | 19-17 | 4 | 42,004 | Paul Rigdon | Todd Ritchie | Curt Leskanic | Joe Beimel | | 182 | 153 | 29 |
| 2001-05-13 | vs PIT | 37 | W 4-1 | 20-17 | 4 | 30,084 | Ben Sheets | Jimmy Anderson | Ben Sheets | Jimmy Anderson | | 186 | 154 | 32 |
| 2001-05-14 | vs PIT | 38 | W 11-8 | 21-17 | 4 | 26,974 | Jamey Wright | Don Wengert | Jamey Wright | Don Wengert | Curt Leskanic | 197 | 162 | 35 |
| 2001-05-15 | @ PHI | 39 | W 14-10 | 22-17 | 3 | 12,307 | Allen Levrault | Amaury Telemaco | Curt Leskanic | Ricky Bottalico | | 211 | 172 | 39 |
| 2001-05-16 | @ PHI | 40 | W 6-1 | 23-17 | 3 | 12,105 | Jimmy Haynes | Bruce Chen | Jimmy Haynes | Bruce Chen | | 217 | 173 | 44 |
| 2001-05-17 | @ PHI | 41 | L 1-2 | 23-18 | 3 | 12,433 | Paul Rigdon | Randy Wolf | Wayne Gomes | Mike DeJean | | 218 | 175 | 43 |
| 2001-05-19 | @ PIT | 42 | L 1-6 | 23-19 | 3 | 37,857 | Ben Sheets | Jimmy Anderson | Jimmy Anderson | Ben Sheets | | 219 | 181 | 38 |
| 2001-05-20 | @ PIT | 43 | L 7-8 | 23-20 | 4 | 35,728 | Jamey Wright | Don Wengert | Josias Manzanillo | David Weathers | Mike Williams | 226 | 189 | 37 |
| 2001-05-22 | vs SLN | 44 | W 5-0 | 24-20 | 4 | 30,200 | Jimmy Haynes | Darryl Kile | Jimmy Haynes | Darryl Kile | | 231 | 189 | 42 |
| 2001-05-23 | vs SLN | 45 | W 7-3 | 25-20 | 3 | 34,613 | Paul Rigdon | Matt Morris | Paul Rigdon | Matt Morris | | 238 | 192 | 46 |
| 2001-05-24 | vs SLN | 46 | L 4-7 | 25-21 | 3 | 40,313 | Ben Sheets | Mike Matthews | Mike Matthews | Ben Sheets | | 242 | 199 | 43 |
| 2001-05-25 | @ CHN | 47 | L 0-1 | 25-22 | 3 | 26,526 | Allen Levrault | Kerry Wood | Kerry Wood | Allen Levrault | | 242 | 200 | 42 |
| 2001-05-27 | @ CHN | 48 | L 1-4 | 25-23 | 3 | 39,095 | Jimmy Haynes | Kevin Tapani | Kevin Tapani | Jimmy Haynes | Tom Gordon | 243 | 204 | 39 |
| 2001-05-28 | @ SLN | 49 | L 2-6 | 25-24 | 3 | 42,455 | Paul Rigdon | Matt Morris | Matt Morris | Paul Rigdon | Jason Christiansen | 245 | 210 | 35 |
| 2001-05-29 | @ SLN | 50 | W 7-0 | 26-24 | 3 | 39,088 | Ben Sheets | Mike Matthews | Ben Sheets | Mike Matthews | | 252 | 210 | 42 |
| 2001-05-30 | @ SLN | 51 | W 11-1 | 27-24 | 3 | 29,842 | Allen Levrault | Andy Benes | Allen Levrault | Andy Benes | | 263 | 211 | 52 |
| 2001-05-31 | @ SLN | 52 | W 6-2 | 28-24 | 3 | 30,928 | Kyle Peterson | Dustin Hermanson | Kyle Peterson | Dustin Hermanson | | 269 | 213 | 56 |
| 2001-06-01 | vs CHN | 53 | L 3-4 | 28-25 | 3 | 42,392 | Jimmy Haynes | Kerry Wood | Kerry Wood | Jimmy Haynes | Tom Gordon | 272 | 217 | 55 |
| 2001-06-02 | vs CHN | 54 | L 4-10 | 28-26 | 4 | 43,400 | Paul Rigdon | Kevin Tapani | Kevin Tapani | Paul Rigdon | | 276 | 227 | 49 |
| 2001-06-03 | vs CHN | 55 | W 4-2 | 29-26 | 3 | 42,385 | Ben Sheets | Julian Tavarez | Ben Sheets | Julian Tavarez | Curt Leskanic | 280 | 229 | 51 |
| 2001-06-05 | vs CIN | 56 | L 3-4 | 29-27 | 3 | 30,766 | Allen Levrault | Chris Reitsma | Mark Wohlers | Will Cunnane | Chris Nichting | 283 | 233 | 50 |
| 2001-06-06 | vs CIN | 57 | L 3-6 | 29-28 | 3 | 35,816 | Jimmy Haynes | Elmer Dessens | Elmer Dessens | Jimmy Haynes | Danny Graves | 286 | 239 | 47 |
| 2001-06-08 | @ DET | 58 | L 4-9 | 29-29 | 4 | 27,770 | Paul Rigdon | Jeff Weaver | Jeff Weaver | Paul Rigdon | | 290 | 248 | 42 |
| 2001-06-09 | @ DET | 59 | L 5-6 | 29-30 | 4 | 26,276 | Ben Sheets | Steve Sparks | Matt Anderson | Curt Leskanic | | 295 | 254 | 41 |
| 2001-06-10 | @ DET | 60 | W 8-3 | 30-30 | 4 | 23,070 | Jamey Wright | Chris Holt | Jamey Wright | Chris Holt | | 303 | 257 | 46 |
| 2001-06-12 | @ CLE | 61 | W 4-2 | 31-30 | 4 | 39,192 | Jimmy Haynes | CC Sabathia | Chad Fox | Paul Shuey | Curt Leskanic | 307 | 259 | 48 |
| 2001-06-13 | @ CLE | 62 | L 2-5 | 31-31 | 4 | 35,679 | Allen Levrault | Bartolo Colon | Bob Wickman | Chad Fox | | 309 | 264 | 45 |
| 2001-06-14 | @ CLE | 63 | W 9-4 | 32-31 | 3 | 41,610 | Ben Sheets | Charles Nagy | Ben Sheets | Charles Nagy | | 318 | 268 | 50 |
| 2001-06-15 | vs KCA | 64 | L 2-4 | 32-32 | 4 | 39,005 | Jamey Wright | Blake Stein | Paul Byrd | Kyle Peterson | Roberto Hernandez | 320 | 272 | 48 |
| 2001-06-16 | vs KCA | 65 | L 1-4 | 32-33 | 4 | 43,060 | Jimmy Haynes | Dan Reichert | Dan Reichert | Jimmy Haynes | Roberto Hernandez | 321 | 276 | 45 |
| 2001-06-17 | vs KCA | 66 | W 5-2 | 33-33 | 4 | 42,554 | Jamey Wright | Blake Stein | Jamey Wright | Blake Stein | Curt Leskanic | 326 | 278 | 48 |
| 2001-06-18 | @ CIN | 67 | W 6-4 | 34-33 | 4 | 21,543 | Allen Levrault | Brian Reith | Allen Levrault | Brian Reith | Curt Leskanic | 332 | 282 | 50 |
| 2001-06-19 | @ CIN | 68 | W 10-8 | 35-33 | 4 | 20,321 | Ben Sheets | Jose Acevedo | Ben Sheets | Jose Acevedo | Ray King | 342 | 290 | 52 |
| 2001-06-20 | @ CIN | 69 | L 3-11 | 35-34 | 4 | 24,418 | Will Cunnane | Chris Reitsma | Chris Reitsma | Will Cunnane | | 345 | 301 | 44 |
| 2001-06-22 | @ CHN | 70 | W 2-1 | 36-34 | 3 | 39,703 | Jimmy Haynes | Kerry Wood | David Weathers | Kerry Wood | Curt Leskanic | 347 | 302 | 45 |
| 2001-06-23 | @ CHN | 71 | W 4-0 | 37-34 | 3 | 40,460 | Jamey Wright | Kevin Tapani | Jamey Wright | Kevin Tapani | | 351 | 302 | 49 |
| 2001-06-24 | @ CHN | 72 | W 6-3 | 38-34 | 3 | 38,501 | Ben Sheets | Jason Bere | Ben Sheets | Jason Bere | Curt Leskanic | 357 | 305 | 52 |
| 2001-06-25 | @ PIT | 73 | L 4-6 | 38-35 | 4 | 22,470 | Allen Levrault | David Williams | David Williams | Allen Levrault | Mike Williams | 361 | 311 | 50 |
| 2001-06-26 | @ PIT | 74 | L 6-7 | 38-36 | 4 | 24,120 | Paul Rigdon | Jimmy Anderson | Omar Olivares | Ray King | | 367 | 318 | 49 |
| 2001-06-27 | @ PIT | 75 | L 2-6 | 38-37 | 4 | 25,756 | Jimmy Haynes | Jason Schmidt | Jason Schmidt | Jimmy Haynes | | 369 | 324 | 45 |
| 2001-06-28 | @ PIT | 76 | L 0-1 | 38-38 | 4 | 36,390 | Jamey Wright | Todd Ritchie | Todd Ritchie | Jamey Wright | Mike Williams | 369 | 325 | 44 |
| 2001-06-29 | vs HOU | 77 | W 6-1 | 39-38 | 4 | 40,069 | Ben Sheets | Shane Reynolds | Ben Sheets | Shane Reynolds | | 375 | 326 | 49 |
| 2001-06-30 | vs HOU | 78 | L 4-7 | 39-39 | 4 | 42,529 | Allen Levrault | Roy Oswalt | Roy Oswalt | Allen Levrault | | 379 | 333 | 46 |
| 2001-07-01 | vs HOU | 79 | L 1-6 | 39-40 | 4 | 38,485 | Paul Rigdon | Wade Miller | Wade Miller | Paul Rigdon | | 380 | 339 | 41 |
| 2001-07-02 | vs HOU | 80 | L 4-6 | 39-41 | 4 | 33,182 | Jimmy Haynes | Tim Redding | Tim Redding | Jimmy Haynes | Billy Wagner | 384 | 345 | 39 |
| 2001-07-03 | vs SLN | 81 | W 2-0 | 40-41 | 3 | 38,375 | Jamey Wright | Dustin Hermanson | Jamey Wright | Steve Kline | David Weathers | 386 | 345 | 41 |
| 2001-07-04 | vs SLN | 82 | L 2-7 | 40-42 | 4 | 31,572 | Ben Sheets | Mike Matthews | Mike Matthews | Ben Sheets | | 388 | 352 | 36 |
| 2001-07-05 | vs SLN | 83 | L 2-5 | 40-43 | 4 | 42,586 | Kyle Peterson | Darryl Kile | Darryl Kile | Kyle Peterson | Mike Timlin | 390 | 357 | 33 |
| 2001-07-06 | @ SFN | 84 | L 2-3 | 40-44 | 4 | 41,604 | Allen Levrault | Mark Gardner | Chad Zerbe | Curt Leskanic | | 392 | 360 | 32 |
| 2001-07-07 | @ SFN | 85 | W 13-3 | 41-44 | 4 | 41,707 | Jimmy Haynes | Shawn Estes | Jimmy Haynes | Shawn Estes | Mike Buddie | 405 | 363 | 42 |
| 2001-07-08 | @ SFN | 86 | W 6-4 | 42-44 | 4 | 41,780 | Jamey Wright | Livan Hernandez | Mike DeJean | Brian Boehringer | | 411 | 367 | 44 |
| 2001-07-12 | vs MIN | 87 | L 5-13 | 42-45 | 4 | 30,920 | Jimmy Haynes | Kyle Lohse | Kyle Lohse | Jimmy Haynes | | 416 | 380 | 36 |
| 2001-07-13 | vs MIN | 88 | W 6-3 | 43-45 | 3 | 41,748 | Allen Levrault | Brad Radke | Allen Levrault | Brad Radke | | 422 | 383 | 39 |
| 2001-07-14 | vs MIN | 89 | L 3-5 | 43-46 | 4 | 43,624 | Jamey Wright | Eric Milton | Bob Wells | David Weathers | LaTroy Hawkins | 425 | 388 | 37 |
| 2001-07-15 | vs CHA | 90 | L 2-3 | 43-47 | 4 | 42,455 | Ben Sheets | Rocky Biddle | Rocky Biddle | Ben Sheets | Keith Foulke | 427 | 391 | 36 |
| 2001-07-16 | vs CHA | 91 | L 5-6 | 43-48 | 4 | 42,487 | Mac Suzuki | James Baldwin | James Baldwin | Ray King | Keith Foulke | 432 | 397 | 35 |
| 2001-07-17 | vs CHA | 92 | L 4-8 | 43-49 | 4 | 40,332 | Jimmy Haynes | Kip Wells | Kip Wells | Jimmy Haynes | Jon Garland | 436 | 405 | 31 |
| 2001-07-18 | @ LAN | 93 | L 0-5 | 43-50 | 4 | 32,844 | Allen Levrault | Chan Ho Park | Chan Ho Park | Allen Levrault | | 436 | 410 | 26 |
| 2001-07-19 | @ LAN | 94 | L 6-8 | 43-51 | 4 | 34,613 | Jamey Wright | Dennis Springer | Matt Herges | David Weathers | Jeff Shaw | 442 | 418 | 24 |
| 2001-07-20 | @ SDN | 95 | L 2-11 | 43-52 | 4 | 24,924 | Ben Sheets | Sterling Hitchcock | Sterling Hitchcock | Ben Sheets | | 444 | 429 | 15 |
| 2001-07-21 | @ SDN | 96 | L 3-5 | 43-53 | 4 | 36,321 | Mac Suzuki | Brian Tollberg | Brian Tollberg | Mac Suzuki | Trevor Hoffman | 447 | 434 | 13 |
| 2001-07-22 | @ SDN | 97 | L 0-4 | 43-54 | 4 | 21,883 | Jimmy Haynes | Bobby Jones | Bobby Jones | Jimmy Haynes | | 447 | 438 | 9 |
| 2001-07-23 | vs LAN | 98 | L 1-3 | 43-55 | 4 | 42,132 | Allen Levrault | Chan Ho Park | Chan Ho Park | Allen Levrault | Jeff Shaw | 448 | 441 | 7 |
| 2001-07-24 | vs LAN | 99 | L 2-7 | 43-56 | 4 | 34,444 | Jamey Wright | Dennis Springer | Dennis Springer | Jamey Wright | | 450 | 448 | 2 |
| 2001-07-25 | vs LAN | 100 | W 4-3 | 44-56 | 4 | 39,223 | Ben Sheets | Luke Prokopec | David Weathers | Matt Herges | | 454 | 451 | 3 |
| 2001-07-27 | vs SDN | 101 | W 8-0 | 45-56 | 4 | 29,520 | Jimmy Haynes | Bobby Jones | Jimmy Haynes | Bobby Jones | | 462 | 451 | 11 |
| 2001-07-28 | vs SDN | 102 | L 2-6 | 45-57 | 4 | 42,096 | Allen Levrault | Woody Williams | Woody Williams | Allen Levrault | Trevor Hoffman | 464 | 457 | 7 |
| 2001-07-29 | vs SDN | 103 | L 5-12 | 45-58 | 4 | 42,189 | Jamey Wright | Kevin Jarvis | Kevin Jarvis | Jamey Wright | | 469 | 469 | 0 |
| 2001-07-31 | vs FLO | 104 | L 1-5 | 45-59 | 4 | 26,087 | Ben Sheets | Ryan Dempster | Ryan Dempster | Ben Sheets | | 470 | 474 | -4 |
| 2001-08-01 | vs FLO | 105 | L 4-5 | 45-60 | 4 | 27,664 | Jimmy Haynes | Matt Clement | Armando Almanza | Ray King | Antonio Alfonseca | 474 | 479 | -5 |
| 2001-08-02 | vs FLO | 106 | W 4-3 | 46-60 | 4 | 33,657 | Allen Levrault | Gary Knotts | Allen Levrault | Gary Knotts | Curt Leskanic | 478 | 482 | -4 |
| 2001-08-03 | vs ATL | 107 | W 3-2 | 47-60 | 4 | 42,259 | Jamey Wright | Jason Marquis | Lance Painter | Jose Cabrera | | 481 | 484 | -3 |
| 2001-08-04 | vs ATL | 108 | L 2-14 | 47-61 | 4 | 42,646 | Ruben Quevedo | John Burkett | John Burkett | Ruben Quevedo | | 483 | 498 | -15 |
| 2001-08-05 | vs ATL | 109 | L 8-12 | 47-62 | 4 | 42,263 | Ben Sheets | Kevin Millwood | Jose Cabrera | Ben Sheets | | 491 | 510 | -19 |
| 2001-08-07 | @ NYN | 110 | L 0-3 | 47-63 | 4 | 27,240 | Jimmy Haynes | Bruce Chen | Bruce Chen | Jimmy Haynes | Armando Benitez | 491 | 513 | -22 |
| 2001-08-08 | @ NYN | 111 | L 4-5 | 47-64 | 4 | 34,619 | Allen Levrault | Steve Trachsel | Steve Trachsel | Allen Levrault | Armando Benitez | 495 | 518 | -23 |
| 2001-08-09 | @ NYN | 112 | L 3-4 | 47-65 | 4 | 27,989 | Jamey Wright | Al Leiter | Al Leiter | Mike DeJean | Rick White | 498 | 522 | -24 |
| 2001-08-10 | @ MON | 113 | W 5-1 | 48-65 | 4 | 4,917 | Ruben Quevedo | Mike Thurman | Ruben Quevedo | Mike Thurman | | 503 | 523 | -20 |
| 2001-08-11 | @ MON | 114 | W 6-0 | 49-65 | 4 | 5,843 | Mac Suzuki | Bobby Munoz | Mac Suzuki | Bobby Munoz | | 509 | 523 | -14 |
| 2001-08-12 | @ MON | 115 | L 0-5 | 49-66 | 4 | 6,280 | Jimmy Haynes | Javier Vazquez | Javier Vazquez | Jimmy Haynes | | 509 | 528 | -19 |
| 2001-08-14 | vs PHI | 116 | L 4-10 | 49-67 | 4 | 34,277 | Allen Levrault | Dave Coggin | Dave Coggin | Allen Levrault | | 513 | 538 | -25 |
| 2001-08-15 | vs PHI | 117 | L 6-8 | 49-68 | 4 | 31,030 | Jamey Wright | Omar Daal | Omar Daal | Jamey Wright | Jose Mesa | 519 | 546 | -27 |
| 2001-08-16 | vs PHI | 118 | W 5-4 | 50-68 | 4 | 34,110 | Ruben Quevedo | Nelson Figueroa | Ruben Quevedo | Nelson Figueroa | Curt Leskanic | 524 | 550 | -26 |
| 2001-08-17 | @ CIN | 119 | W 5-1 | 51-68 | 4 | 29,214 | Mac Suzuki | Lance Davis | Mac Suzuki | Lance Davis | | 529 | 551 | -22 |
| 2001-08-18 | @ CIN | 120 | W 6-5 | 52-68 | 4 | 26,241 | Jimmy Haynes | Elmer Dessens | Jimmy Haynes | Elmer Dessens | | 535 | 556 | -21 |
| 2001-08-19 | @ CIN | 121 | W 6-4 | 53-68 | 4 | 20,577 | Nick Neugebauer | Dennys Reyes | Nick Neugebauer | Dennys Reyes | Mike DeJean | 541 | 560 | -19 |
| 2001-08-20 | @ CHN | 122 | L 4-7 | 54-69 | 4 | 0 | Allen Levrault | Jon Lieber | Kyle Farnsworth | Ray King | Tom Gordon | 545 | 567 | -22 |
| 2001-08-20 | @ CHN | 123 | W 10-2 | 54-69 | 4 | 40,657 | Jamey Wright | Carlos Zambrano | Jamey Wright | Carlos Zambrano | | 555 | 569 | -14 |
| 2001-08-21 | @ CHN | 124 | W 3-1 | 55-69 | 4 | 35,599 | Ruben Quevedo | Juan Cruz | Ruben Quevedo | Juan Cruz | Curt Leskanic | 558 | 570 | -12 |
| 2001-08-22 | @ CHN | 125 | L 3-16 | 55-70 | 4 | 33,904 | Mac Suzuki | Kevin Tapani | Kevin Tapani | Mac Suzuki | | 561 | 586 | -25 |
| 2001-08-23 | @ CHN | 126 | W 8-1 | 56-70 | 4 | 35,064 | Jimmy Haynes | Julian Tavarez | Mac Suzuki | Julian Tavarez | | 569 | 587 | -18 |
| 2001-08-24 | vs COL | 127 | L 6-12 | 56-71 | 4 | 40,657 | Nick Neugebauer | Denny Neagle | Denny Neagle | Nick Neugebauer | | 575 | 599 | -24 |
| 2001-08-25 | vs COL | 128 | W 5-4 | 57-71 | 4 | 42,139 | Jamey Wright | John Thomson | Mike DeJean | Gabe White | Curt Leskanic | 580 | 603 | -23 |
| 2001-08-26 | vs COL | 129 | L 2-3 | 57-72 | 4 | 42,239 | Ruben Quevedo | Mike Hampton | Mike Hampton | Ruben Quevedo | Jay Powell | 582 | 606 | -24 |
| 2001-08-27 | vs PIT | 130 | W 12-5 | 58-72 | 4 | 26,289 | Rocky Coppinger | Joe Beimel | Rocky Coppinger | Joe Beimel | Mike Buddie | 594 | 611 | -17 |
| 2001-08-28 | vs PIT | 131 | L 5-6 | 58-73 | 4 | 23,579 | Mac Suzuki | Tony McKnight | Scott Sauerbeck | Curt Leskanic | Mike Fetters | 599 | 617 | -18 |
| 2001-08-29 | vs PIT | 132 | W 9-8 | 59-73 | 4 | 24,551 | Allen Levrault | Jimmy Anderson | Allen Levrault | Jimmy Anderson | Chad Fox | 608 | 625 | -17 |
| 2001-08-31 | vs HOU | 133 | L 2-3 | 59-74 | 4 | 26,486 | Jamey Wright | Dave Mlicki | Mike Williams | Jamey Wright | Billy Wagner | 610 | 628 | -18 |
| 2001-09-01 | vs HOU | 134 | W 4-3 | 60-74 | 4 | 28,818 | Rocky Coppinger | Shane Reynolds | Chad Fox | Michael Jackson | | 614 | 631 | -17 |
| 2001-09-02 | vs HOU | 135 | L 0-1 | 60-75 | 4 | 38,140 | Mac Suzuki | Wade Miller | Wade Miller | Mac Suzuki | Billy Wagner | 614 | 632 | -18 |
| 2001-09-03 | @ PIT | 136 | W 12-7 | 61-76 | 4 | 0 | Jeff D'Amico | Ryan Vogelsong | Mark Leiter | Ryan Vogelsong | | 626 | 639 | -13 |
| 2001-09-03 | @ PIT | 137 | L 2-3 | 61-76 | 4 | 29,003 | Ruben Quevedo | Jimmy Anderson | Mike Fetters | Chad Fox | | 628 | 642 | -14 |
| 2001-09-04 | @ PIT | 138 | L 2-5 | 61-77 | 4 | 17,293 | Allen Levrault | Bronson Arroyo | Bronson Arroyo | Allen Levrault | Mike Fetters | 630 | 647 | -17 |
| 2001-09-05 | @ PIT | 139 | L 1-5 | 61-78 | 4 | 18,866 | Jamey Wright | Todd Ritchie | Todd Ritchie | Jamey Wright | | 631 | 652 | -21 |
| 2001-09-06 | @ HOU | 140 | W 4-3 | 62-78 | 4 | 31,895 | Rocky Coppinger | Shane Reynolds | Chad Fox | Billy Wagner | Curt Leskanic | 635 | 655 | -20 |
| 2001-09-07 | @ HOU | 141 | L 3-5 | 62-79 | 4 | 35,527 | Mac Suzuki | Wade Miller | Wade Miller | Mac Suzuki | Billy Wagner | 638 | 660 | -22 |
| 2001-09-08 | @ HOU | 142 | W 7-2 | 63-79 | 4 | 41,033 | Ruben Quevedo | Ron Villone | Ruben Quevedo | Ron Villone | | 645 | 662 | -17 |
| 2001-09-09 | @ HOU | 143 | L 0-8 | 63-80 | 4 | 35,091 | Jeff D'Amico | Roy Oswalt | Roy Oswalt | Jeff D'Amico | | 645 | 670 | -25 |
| 2001-09-10 | vs SLN | 144 | L 0-8 | 63-81 | 4 | 31,780 | Jamey Wright | Darryl Kile | Darryl Kile | Jamey Wright | Mike Matthews | 645 | 678 | -33 |
| 2001-09-17 | @ SLN | 145 | L 1-2 | 63-82 | 4 | 32,563 | Ruben Quevedo | Bud Smith | Bud Smith | Ruben Quevedo | Steve Kline | 646 | 680 | -34 |
| 2001-09-18 | @ SLN | 146 | L 4-9 | 63-83 | 4 | 41,653 | Jamey Wright | Dustin Hermanson | Dustin Hermanson | Jamey Wright | | 650 | 689 | -39 |
| 2001-09-19 | @ SLN | 147 | L 2-8 | 63-84 | 4 | 29,332 | Jeff D'Amico | Matt Morris | Matt Morris | Jeff D'Amico | | 652 | 697 | -45 |
| 2001-09-21 | vs CIN | 148 | L 2-5 | 63-85 | 4 | 26,412 | Ben Sheets | Lance Davis | Lance Davis | Mac Suzuki | Danny Graves | 654 | 702 | -48 |
| 2001-09-22 | vs CIN | 149 | L 1-3 | 63-86 | 4 | 35,939 | Ruben Quevedo | Jose Acevedo | Jose Acevedo | Ruben Quevedo | Danny Graves | 655 | 705 | -50 |
| 2001-09-23 | vs CIN | 150 | W 6-3 | 64-86 | 4 | 27,940 | Jamey Wright | Elmer Dessens | Jamey Wright | Elmer Dessens | Curt Leskanic | 661 | 708 | -47 |
| 2001-09-25 | @ ARI | 151 | W 9-4 | 65-86 | 4 | 35,032 | Jeff D'Amico | Albie Lopez | Jeff D'Amico | Albie Lopez | | 670 | 712 | -42 |
| 2001-09-26 | @ ARI | 152 | L 9-15 | 65-87 | 4 | 30,658 | Ben Sheets | Bobby Witt | Bobby Witt | Mike Buddie | | 679 | 727 | -48 |
| 2001-09-27 | @ ARI | 153 | L 11-13 | 65-88 | 4 | 28,359 | Ruben Quevedo | Randy Johnson | Randy Johnson | Ruben Quevedo | Byung-Hyun Kim | 690 | 740 | -50 |
| 2001-09-28 | @ COL | 154 | L 5-6 | 65-89 | 4 | 44,109 | Jamey Wright | Scott Elarton | Jay Powell | Curt Leskanic | | 695 | 746 | -51 |
| 2001-09-29 | @ COL | 155 | L 12-14 | 65-90 | 4 | 35,848 | Mac Suzuki | Denny Neagle | Justin Speier | Jimmy Haynes | Jose Jimenez | 707 | 760 | -53 |
| 2001-09-30 | @ COL | 156 | L 0-10 | 65-91 | 5 | 31,545 | Jeff D'Amico | John Thomson | John Thomson | Jeff D'Amico | | 707 | 770 | -63 |
| 2001-10-02 | vs SLN | 157 | L 1-5 | 65-92 | 5 | 30,890 | Ben Sheets | Darryl Kile | Darryl Kile | Ben Sheets | | 708 | 775 | -67 |
| 2001-10-03 | vs SLN | 158 | W 9-7 | 66-92 | 5 | 33,148 | Jamey Wright | Bud Smith | Jamey Wright | Bud Smith | Chad Fox | 717 | 782 | -65 |
| 2001-10-04 | vs SLN | 159 | L 3-10 | 66-93 | 5 | 28,802 | Jimmy Haynes | Matt Morris | Matt Morris | Jimmy Haynes | | 720 | 792 | -72 |
| 2001-10-05 | vs ARI | 160 | L 0-5 | 66-94 | 5 | 24,700 | Allen Levrault | Albie Lopez | Albie Lopez | Allen Levrault | | 720 | 797 | -77 |
| 2001-10-06 | vs ARI | 161 | W 5-4 | 67-94 | 4 | 40,038 | Jeff D'Amico | Miguel Batista | Chad Fox | Erik Sabel | | 725 | 801 | -76 |
| 2001-10-07 | vs ARI | 162 | W 15-5 | 68-94 | 4 | 31,761 | Ben Sheets | Eric Knott | Ben Sheets | Eric Knott | | 740 | 806 | -66 |