| 1996-04-02 | vs KCA | 1 | W 4-2 | 1-0 | 1 | 46,818 | Mike Mussina | Kevin Appier | Mike Mussina | Kevin Appier | Randy Myers | 4 | 2 | 2 |
| 1996-04-03 | vs KCA | 2 | W 7-1 | 2-0 | 1 | 40,068 | David Wells | Mark Gubicza | David Wells | Mark Gubicza | | 11 | 3 | 8 |
| 1996-04-04 | vs KCA | 3 | W 5-3 | 3-0 | 1 | 38,753 | Scott Erickson | Chris Haney | Arthur Rhodes | Hipolito Pichardo | Randy Myers | 16 | 6 | 10 |
| 1996-04-05 | @ MIN | 4 | W 2-1 | 4-0 | 1 | 22,744 | Kent Mercker | LaTroy Hawkins | Kent Mercker | Eddie Guardado | Randy Myers | 18 | 7 | 11 |
| 1996-04-06 | @ MIN | 5 | L 3-8 | 4-1 | 1 | 22,334 | Jimmy Haynes | Brad Radke | Brad Radke | Jimmy Haynes | | 21 | 15 | 6 |
| 1996-04-07 | @ MIN | 6 | W 4-2 | 5-1 | 1 | 14,580 | Mike Mussina | Rich Robertson | Mike Mussina | Rich Robertson | Randy Myers | 25 | 17 | 8 |
| 1996-04-10 | vs CLE | 7 | W 3-2 | 6-1 | 1 | 45,097 | David Wells | Jack McDowell | Jesse Orosco | Julian Tavarez | | 28 | 19 | 9 |
| 1996-04-11 | vs CLE | 8 | W 14-4 | 7-1 | 1 | 43,189 | Scott Erickson | Orel Hershiser | Scott Erickson | Orel Hershiser | Arthur Rhodes | 42 | 23 | 19 |
| 1996-04-12 | vs MIN | 9 | W 3-2 | 8-1 | 1 | 42,602 | Mike Mussina | Rich Robertson | Mike Mussina | Rich Robertson | | 45 | 25 | 20 |
| 1996-04-13 | vs MIN | 10 | W 7-6 | 9-1 | 1 | 42,644 | Kent Mercker | LaTroy Hawkins | Armando Benitez | Pat Mahomes | | 52 | 31 | 21 |
| 1996-04-14 | vs MIN | 11 | L 1-4 | 9-2 | 1 | 42,660 | Jimmy Haynes | Frankie Rodriguez | Frankie Rodriguez | Jimmy Haynes | Dave Stevens | 53 | 35 | 18 |
| 1996-04-16 | vs BOS | 12 | W 6-1 | 10-2 | 1 | 40,017 | David Wells | Roger Clemens | David Wells | Roger Clemens | | 59 | 36 | 23 |
| 1996-04-17 | vs BOS | 13 | W 6-5 | 11-2 | 1 | 40,258 | Scott Erickson | Aaron Sele | Arthur Rhodes | Mike Maddux | | 65 | 41 | 24 |
| 1996-04-18 | vs BOS | 14 | L 7-10 | 11-3 | 1 | 47,283 | Mike Mussina | Jamie Moyer | Jamie Moyer | Mike Mussina | Heathcliff Slocumb | 72 | 51 | 21 |
| 1996-04-19 | @ TEX | 15 | L 7-26 | 11-4 | 1 | 41,184 | Kent Mercker | Roger Pavlik | Dennis Cook | Kent Mercker | Ed Vosberg | 79 | 77 | 2 |
| 1996-04-20 | @ TEX | 16 | L 3-8 | 11-5 | 1 | 45,358 | Jimmy Haynes | Kevin Gross | Kevin Gross | Jimmy Haynes | | 82 | 85 | -3 |
| 1996-04-21 | @ TEX | 17 | L 6-9 | 11-6 | 1 | 39,456 | David Wells | Darren Oliver | Darren Oliver | David Wells | | 88 | 94 | -6 |
| 1996-04-22 | @ CLE | 18 | L 3-6 | 11-7 | 1 | 42,236 | Scott Erickson | Charles Nagy | Charles Nagy | Scott Erickson | Jose Mesa | 91 | 100 | -9 |
| 1996-04-23 | @ CLE | 19 | L 8-9 | 11-8 | 1 | 40,770 | Mike Mussina | Albie Lopez | Chad Ogea | Mike Mussina | Jose Mesa | 99 | 109 | -10 |
| 1996-04-24 | @ KCA | 20 | W 11-8 | 12-8 | 1 | 13,962 | Kent Mercker | Chris Haney | Kent Mercker | Chris Haney | | 110 | 117 | -7 |
| 1996-04-25 | @ KCA | 21 | W 3-2 | 13-8 | 1 | 16,090 | Arthur Rhodes | Julio Valera | Arthur Rhodes | Julio Valera | Randy Myers | 113 | 119 | -6 |
| 1996-04-26 | vs TEX | 22 | L 4-5 | 13-9 | 1 | 44,022 | David Wells | Darren Oliver | Mark Brandenburg | David Wells | Mike Henneman | 117 | 124 | -7 |
| 1996-04-27 | vs TEX | 23 | L 2-4 | 13-10 | 1 | 47,311 | Scott Erickson | Bobby Witt | Bobby Witt | Scott Erickson | Ed Vosberg | 119 | 128 | -9 |
| 1996-04-28 | vs TEX | 24 | L 4-5 | 13-11 | 2 | 47,327 | Mike Mussina | Ken Hill | Gil Heredia | Roger McDowell | Mike Henneman | 123 | 133 | -10 |
| 1996-04-29 | vs TEX | 25 | W 8-7 | 14-11 | 1 | 41,503 | Kent Mercker | Roger Pavlik | Jimmy Haynes | Rick Helling | Randy Myers | 131 | 140 | -9 |
| 1996-04-30 | vs NYA | 26 | L 10-13 | 14-12 | 2 | 43,117 | Arthur Rhodes | Andy Pettitte | Jeff Nelson | Keith Shepherd | John Wetteland | 141 | 153 | -12 |
| 1996-05-01 | vs NYA | 27 | L 6-11 | 14-13 | 2 | 47,472 | David Wells | Kenny Rogers | Andy Pettitte | Kent Mercker | | 147 | 164 | -17 |
| 1996-05-03 | vs MIL | 28 | W 8-2 | 15-13 | 2 | 41,037 | Scott Erickson | Ricky Bones | Scott Erickson | Ricky Bones | | 155 | 166 | -11 |
| 1996-05-04 | vs MIL | 29 | W 10-5 | 16-13 | 2 | 44,175 | Mike Mussina | Steve Sparks | Mike Mussina | Steve Sparks | | 165 | 171 | -6 |
| 1996-05-05 | vs MIL | 30 | L 1-13 | 16-14 | 2 | 46,027 | Jimmy Haynes | Ben McDonald | Ben McDonald | Jimmy Haynes | | 166 | 184 | -18 |
| 1996-05-07 | @ CHA | 31 | L 2-3 | 16-15 | 2 | 16,130 | David Wells | Alex Fernandez | Alex Fernandez | David Wells | Roberto Hernandez | 168 | 187 | -19 |
| 1996-05-08 | @ CHA | 32 | L 2-11 | 16-16 | 2 | 14,974 | Scott Erickson | James Baldwin | James Baldwin | Scott Erickson | | 170 | 198 | -28 |
| 1996-05-09 | @ CHA | 33 | W 6-4 | 17-16 | 2 | 14,507 | Mike Mussina | Wilson Alvarez | Mike Mussina | Wilson Alvarez | Randy Myers | 176 | 202 | -26 |
| 1996-05-10 | @ MIL | 34 | W 10-7 | 18-16 | 2 | 9,520 | Jimmy Haynes | Ben McDonald | Jesse Orosco | Ramon Garcia | Roger McDowell | 186 | 209 | -23 |
| 1996-05-11 | @ MIL | 35 | W 5-3 | 19-16 | 2 | 21,081 | Kent Mercker | Scott Karl | Arthur Rhodes | Mike Potts | Randy Myers | 191 | 212 | -21 |
| 1996-05-12 | @ MIL | 36 | L 4-6 | 19-17 | 2 | 14,333 | Scott Erickson | Angel Miranda | Angel Miranda | Scott Erickson | Mike Fetters | 195 | 218 | -23 |
| 1996-05-13 | @ OAK | 37 | W 4-3 | 20-17 | 2 | 8,204 | Rick Krivda | Doug Johns | Rick Krivda | Doug Johns | Randy Myers | 199 | 221 | -22 |
| 1996-05-14 | @ OAK | 38 | W 9-1 | 21-17 | 2 | 8,466 | Mike Mussina | Carlos Reyes | Mike Mussina | Carlos Reyes | | 208 | 222 | -14 |
| 1996-05-17 | vs SEA | 39 | W 14-13 | 22-17 | 2 | 47,259 | Jimmy Haynes | Bob Wolcott | Alan Mills | Norm Charlton | | 222 | 235 | -13 |
| 1996-05-18 | vs SEA | 40 | L 3-7 | 22-18 | 2 | 46,434 | Kent Mercker | Bob Milacki | Bob Milacki | Kent Mercker | | 225 | 242 | -17 |
| 1996-05-19 | vs SEA | 41 | W 8-7 | 23-18 | 2 | 47,565 | Mike Mussina | Sterling Hitchcock | Mike Mussina | Edwin Hurtado | Randy Myers | 233 | 249 | -16 |
| 1996-05-20 | vs CAL | 42 | W 13-1 | 24-18 | 2 | 43,492 | David Wells | Jason Grimsley | David Wells | Jason Grimsley | | 246 | 250 | -4 |
| 1996-05-21 | vs CAL | 43 | L 2-5 | 24-19 | 2 | 39,974 | Rick Krivda | Shawn Boskie | Shawn Boskie | Rick Krivda | Troy Percival | 248 | 255 | -7 |
| 1996-05-22 | vs CAL | 44 | W 10-5 | 25-19 | 2 | 45,817 | Jimmy Haynes | Jim Abbott | Jimmy Haynes | Jim Abbott | Roger McDowell | 258 | 260 | -2 |
| 1996-05-24 | vs OAK | 45 | W 5-4 | 26-19 | 2 | 45,024 | Mike Mussina | Don Wengert | Roger McDowell | Carlos Reyes | | 263 | 264 | -1 |
| 1996-05-25 | vs OAK | 46 | L 3-6 | 26-20 | 2 | 47,353 | David Wells | Doug Johns | Doug Johns | David Wells | Buddy Groom | 266 | 270 | -4 |
| 1996-05-26 | vs OAK | 47 | W 6-1 | 27-20 | 2 | 47,401 | Kent Mercker | Bobby Chouinard | Kent Mercker | Bobby Chouinard | Roger McDowell | 272 | 271 | 1 |
| 1996-05-28 | @ SEA | 48 | W 12-8 | 28-20 | 1 | 23,235 | Scott Erickson | Bob Wolcott | Arthur Rhodes | Lee Guetterman | Jimmy Haynes | 284 | 279 | 5 |
| 1996-05-29 | @ SEA | 49 | L 8-9 | 28-21 | 1 | 20,253 | Mike Mussina | Sterling Hitchcock | Norm Charlton | Randy Myers | | 292 | 288 | 4 |
| 1996-05-31 | @ CAL | 50 | L 3-10 | 28-22 | 2 | 21,603 | David Wells | Mark Langston | Mark Langston | David Wells | | 295 | 298 | -3 |
| 1996-06-01 | @ CAL | 51 | L 3-8 | 28-23 | 2 | 35,350 | Jimmy Haynes | Shawn Boskie | Shawn Boskie | Jimmy Haynes | | 298 | 306 | -8 |
| 1996-06-02 | @ CAL | 52 | W 14-1 | 29-23 | 2 | 33,704 | Scott Erickson | Jim Abbott | Scott Erickson | Jim Abbott | | 312 | 307 | 5 |
| 1996-06-04 | vs DET | 53 | W 10-7 | 30-23 | 2 | 43,727 | Mike Mussina | Greg Gohr | Mike Mussina | Greg Gohr | Randy Myers | 322 | 314 | 8 |
| 1996-06-05 | vs DET | 54 | W 6-4 | 31-23 | 2 | 43,087 | David Wells | Omar Olivares | Arthur Rhodes | Mike Myers | Randy Myers | 328 | 318 | 10 |
| 1996-06-06 | vs DET | 55 | W 13-6 | 32-23 | 2 | 46,269 | Jimmy Haynes | Felipe Lira | Rick Krivda | Felipe Lira | | 341 | 324 | 17 |
| 1996-06-07 | vs CHA | 56 | L 2-8 | 32-24 | 2 | 47,209 | Scott Erickson | Alex Fernandez | Alex Fernandez | Scott Erickson | | 343 | 332 | 11 |
| 1996-06-08 | vs CHA | 57 | L 1-2 | 32-25 | 2 | 47,634 | Kent Mercker | James Baldwin | James Baldwin | Kent Mercker | Roberto Hernandez | 344 | 334 | 10 |
| 1996-06-09 | vs CHA | 58 | L 9-12 | 32-26 | 2 | 47,352 | Mike Mussina | Wilson Alvarez | Matt Karchner | Mike Mussina | Roberto Hernandez | 353 | 346 | 7 |
| 1996-06-10 | @ DET | 59 | L 3-8 | 32-27 | 2 | 10,655 | David Wells | Omar Olivares | Omar Olivares | David Wells | | 356 | 354 | 2 |
| 1996-06-11 | @ DET | 60 | W 12-9 | 33-27 | 2 | 10,874 | Rocky Coppinger | Felipe Lira | Rocky Coppinger | Felipe Lira | | 368 | 363 | 5 |
| 1996-06-12 | @ DET | 61 | W 10-7 | 34-27 | 2 | 12,043 | Scott Erickson | Brian Williams | Arthur Rhodes | Richie Lewis | Randy Myers | 378 | 370 | 8 |
| 1996-06-13 | @ KCA | 62 | L 2-10 | 34-28 | 2 | 20,108 | Kent Mercker | Doug Linton | Doug Linton | Kent Mercker | | 380 | 380 | 0 |
| 1996-06-14 | @ KCA | 63 | W 6-1 | 35-28 | 2 | 28,502 | Mike Mussina | Mark Gubicza | Mike Mussina | Mark Gubicza | | 386 | 381 | 5 |
| 1996-06-15 | @ KCA | 64 | L 6-7 | 35-29 | 2 | 24,784 | David Wells | Chris Haney | Mike Magnante | Rick Krivda | | 392 | 388 | 4 |
| 1996-06-16 | @ KCA | 65 | W 13-5 | 36-29 | 2 | 19,437 | Rocky Coppinger | Tim Belcher | Rocky Coppinger | Jason Jacome | Alan Mills | 405 | 393 | 12 |
| 1996-06-17 | vs TEX | 66 | W 1-1 | 37-29 | 2 | 45,581 | Scott Erickson | Roger Pavlik | | | | 406 | 394 | 12 |
| 1996-06-18 | vs TEX | 67 | L 0-7 | 37-30 | 2 | 47,318 | Kent Mercker | Darren Oliver | Darren Oliver | Kent Mercker | | 406 | 401 | 5 |
| 1996-06-19 | vs TEX | 68 | L 2-3 | 37-31 | 2 | 45,581 | Mike Mussina | Bobby Witt | Bobby Witt | Mike Mussina | Jeff Russell | 408 | 404 | 4 |
| 1996-06-20 | vs TEX | 69 | W 3-2 | 38-31 | 2 | 21,748 | David Wells | Kevin Gross | David Wells | Kevin Gross | Randy Myers | 411 | 406 | 5 |
| 1996-06-21 | vs KCA | 70 | W 9-3 | 39-31 | 2 | 47,644 | Rocky Coppinger | Chris Haney | Arthur Rhodes | Chris Haney | | 420 | 409 | 11 |
| 1996-06-22 | vs KCA | 71 | W 5-3 | 40-31 | 2 | 47,534 | Scott Erickson | Tim Belcher | Scott Erickson | Jeff Montgomery | | 425 | 412 | 13 |
| 1996-06-23 | vs KCA | 72 | L 0-4 | 40-32 | 2 | 47,608 | Rick Krivda | Kevin Appier | Kevin Appier | Rick Krivda | | 425 | 416 | 9 |
| 1996-06-24 | @ TEX | 73 | W 8-3 | 41-32 | 2 | 39,701 | Mike Mussina | Bobby Witt | Mike Mussina | Bobby Witt | | 433 | 419 | 14 |
| 1996-06-25 | @ TEX | 74 | L 2-5 | 41-33 | 2 | 41,685 | David Wells | Kevin Gross | Kevin Gross | David Wells | Mike Henneman | 435 | 424 | 11 |
| 1996-06-26 | @ TEX | 75 | L 5-6 | 41-34 | 2 | 38,984 | Rocky Coppinger | Ken Hill | Dennis Cook | Jesse Orosco | Mike Henneman | 440 | 430 | 10 |
| 1996-06-27 | @ NYA | 76 | L 2-3 | 41-35 | 2 | 34,161 | Scott Erickson | Kenny Rogers | Kenny Rogers | Scott Erickson | John Wetteland | 442 | 433 | 9 |
| 1996-06-28 | @ NYA | 77 | W 7-4 | 42-35 | 2 | 43,515 | Rick Krivda | Dwight Gooden | Arthur Rhodes | Mariano Rivera | Randy Myers | 449 | 437 | 12 |
| 1996-06-29 | @ NYA | 78 | L 3-4 | 42-36 | 2 | 45,295 | Mike Mussina | Andy Pettitte | Andy Pettitte | Mike Mussina | John Wetteland | 452 | 441 | 11 |
| 1996-06-30 | @ NYA | 79 | W 9-1 | 43-36 | 2 | 40,200 | David Wells | Ramiro Mendoza | David Wells | Ramiro Mendoza | | 461 | 442 | 19 |
| 1996-07-01 | @ TOR | 80 | W 7-4 | 44-36 | 2 | 43,377 | Rocky Coppinger | Pat Hentgen | Rocky Coppinger | Pat Hentgen | Randy Myers | 468 | 446 | 22 |
| 1996-07-02 | @ TOR | 81 | W 8-2 | 45-36 | 2 | 32,150 | Scott Erickson | Paul Quantrill | Scott Erickson | Paul Quantrill | | 476 | 448 | 28 |
| 1996-07-03 | @ TOR | 82 | L 2-5 | 45-37 | 2 | 32,365 | Rick Krivda | Juan Guzman | Juan Guzman | Rick Krivda | Mike Timlin | 478 | 453 | 25 |
| 1996-07-04 | vs BOS | 83 | W 8-6 | 46-37 | 2 | 47,075 | Mike Mussina | Tim Wakefield | Mike Mussina | Tim Wakefield | Randy Myers | 486 | 459 | 27 |
| 1996-07-05 | vs BOS | 84 | L 3-7 | 46-38 | 2 | 47,237 | David Wells | Aaron Sele | Aaron Sele | David Wells | | 489 | 466 | 23 |
| 1996-07-06 | vs BOS | 85 | W 4-3 | 47-38 | 2 | 47,500 | Rocky Coppinger | Roger Clemens | Rocky Coppinger | Roger Clemens | Randy Myers | 493 | 469 | 24 |
| 1996-07-07 | vs BOS | 86 | L 5-7 | 47-39 | 2 | 47,532 | Scott Erickson | Tom Gordon | Joe Hudson | Randy Myers | Heathcliff Slocumb | 498 | 476 | 22 |
| 1996-07-11 | vs NYA | 87 | L 2-4 | 47-40 | 2 | 46,760 | Mike Mussina | Jimmy Key | Jimmy Key | Mike Mussina | John Wetteland | 500 | 480 | 20 |
| 1996-07-13 | vs NYA | 88 | L 2-3 | 47-42 | 2 | 0 | David Wells | Kenny Rogers | Jeff Nelson | David Wells | John Wetteland | 502 | 483 | 19 |
| 1996-07-13 | vs NYA | 89 | L 5-7 | 47-42 | 2 | 46,451 | Rocky Coppinger | Dwight Gooden | Dwight Gooden | Arthur Rhodes | John Wetteland | 507 | 490 | 17 |
| 1996-07-14 | vs NYA | 90 | L 1-4 | 47-43 | 2 | 47,658 | Scott Erickson | Andy Pettitte | Andy Pettitte | Scott Erickson | John Wetteland | 508 | 494 | 14 |
| 1996-07-15 | vs TOR | 91 | W 8-6 | 48-43 | 2 | 43,192 | Rick Krivda | Huck Flener | Jimmy Haynes | Mike Timlin | | 516 | 500 | 16 |
| 1996-07-16 | vs TOR | 92 | L 0-6 | 48-44 | 2 | 45,851 | Mike Mussina | Juan Guzman | Juan Guzman | Mike Mussina | | 516 | 506 | 10 |
| 1996-07-17 | vs TOR | 93 | W 11-10 | 49-44 | 2 | 45,955 | Kent Mercker | Erik Hanson | Rocky Coppinger | Mike Timlin | | 527 | 516 | 11 |
| 1996-07-18 | @ BOS | 94 | W 6-3 | 50-44 | 2 | 33,014 | David Wells | Aaron Sele | David Wells | Aaron Sele | Randy Myers | 533 | 519 | 14 |
| 1996-07-19 | @ BOS | 95 | L 2-13 | 50-45 | 2 | 32,262 | Scott Erickson | Jamie Moyer | Jamie Moyer | Scott Erickson | | 535 | 532 | 3 |
| 1996-07-20 | @ BOS | 96 | L 0-2 | 50-46 | 2 | 33,590 | Rocky Coppinger | Tim Wakefield | Tim Wakefield | Rocky Coppinger | Heathcliff Slocumb | 535 | 534 | 1 |
| 1996-07-21 | @ BOS | 97 | W 10-6 | 51-46 | 2 | 34,423 | Mike Mussina | Roger Clemens | Randy Myers | Mike Stanton | | 545 | 540 | 5 |
| 1996-07-22 | vs MIN | 98 | L 5-9 | 51-47 | 2 | 42,129 | Jimmy Haynes | Rich Robertson | Rich Robertson | Jimmy Haynes | Mike Trombley | 550 | 549 | 1 |
| 1996-07-23 | vs MIN | 99 | L 2-3 | 51-48 | 2 | 42,006 | David Wells | Rick Aguilera | Rick Aguilera | David Wells | Dan Naulty | 552 | 552 | 0 |
| 1996-07-24 | vs MIN | 100 | L 4-11 | 51-49 | 2 | 46,181 | Scott Erickson | Frankie Rodriguez | Frankie Rodriguez | Scott Erickson | | 556 | 563 | -7 |
| 1996-07-25 | vs CLE | 101 | L 7-10 | 51-50 | 2 | 47,025 | Rocky Coppinger | Charles Nagy | Charles Nagy | Rocky Coppinger | | 563 | 573 | -10 |
| 1996-07-26 | vs CLE | 102 | L 9-14 | 51-51 | 2 | 46,751 | Mike Mussina | Greg Swindell | Paul Assenmacher | Mike Mussina | | 572 | 587 | -15 |
| 1996-07-27 | vs CLE | 103 | W 14-2 | 52-51 | 2 | 47,360 | David Wells | Orel Hershiser | David Wells | Orel Hershiser | | 586 | 589 | -3 |
| 1996-07-28 | vs CLE | 104 | L 3-6 | 52-52 | 2 | 46,273 | Scott Erickson | Chad Ogea | Jose Mesa | Garrett Stephenson | | 589 | 595 | -6 |
| 1996-07-30 | @ MIN | 105 | W 16-4 | 53-52 | 2 | 16,708 | Rocky Coppinger | Frankie Rodriguez | Rocky Coppinger | Frankie Rodriguez | | 605 | 599 | 6 |
| 1996-07-31 | @ MIN | 106 | W 9-3 | 54-52 | 2 | 15,897 | Mike Mussina | Brad Radke | Mike Mussina | Mike Trombley | | 614 | 602 | 12 |
| 1996-08-01 | @ MIN | 107 | W 4-2 | 55-52 | 2 | 20,379 | David Wells | Rich Robertson | David Wells | Rich Robertson | Randy Myers | 618 | 604 | 14 |
| 1996-08-02 | @ CLE | 108 | L 1-11 | 55-53 | 2 | 42,465 | Scott Erickson | Orel Hershiser | Orel Hershiser | Scott Erickson | | 619 | 615 | 4 |
| 1996-08-03 | @ CLE | 109 | W 9-4 | 56-53 | 2 | 42,448 | Rick Krivda | Chad Ogea | Jesse Orosco | Chad Ogea | | 628 | 619 | 9 |
| 1996-08-04 | @ CLE | 110 | L 2-14 | 56-54 | 2 | 42,349 | Rocky Coppinger | Brian Anderson | Brian Anderson | Rocky Coppinger | | 630 | 633 | -3 |
| 1996-08-05 | @ CLE | 111 | W 13-10 | 57-54 | 2 | 40,863 | David Wells | Charles Nagy | David Wells | Paul Assenmacher | | 643 | 643 | 0 |
| 1996-08-06 | @ MIL | 112 | W 13-3 | 58-54 | 2 | 17,075 | Mike Mussina | Ben McDonald | Mike Mussina | Ben McDonald | | 656 | 646 | 10 |
| 1996-08-07 | @ MIL | 113 | W 12-2 | 59-54 | 2 | 20,287 | Scott Erickson | Scott Karl | Scott Erickson | Scott Karl | | 668 | 648 | 20 |
| 1996-08-08 | @ MIL | 114 | W 6-4 | 60-54 | 2 | 18,620 | Rocky Coppinger | Jeff D'Amico | Rocky Coppinger | Jeff D'Amico | Randy Myers | 674 | 652 | 22 |
| 1996-08-09 | @ CHA | 115 | L 3-4 | 60-55 | 2 | 23,995 | David Wells | James Baldwin | Bill Simas | Randy Myers | | 677 | 656 | 21 |
| 1996-08-10 | @ CHA | 116 | W 13-4 | 61-55 | 2 | 26,772 | Mike Mussina | Wilson Alvarez | Mike Mussina | Wilson Alvarez | Roger McDowell | 690 | 660 | 30 |
| 1996-08-11 | @ CHA | 117 | L 5-8 | 61-56 | 2 | 27,088 | Scott Erickson | Kevin Tapani | Kevin Tapani | Alan Mills | Roberto Hernandez | 695 | 668 | 27 |
| 1996-08-13 | vs MIL | 118 | W 4-3 | 62-56 | 2 | 44,461 | Rocky Coppinger | Scott Karl | Archie Corbin | Graeme Lloyd | Randy Myers | 699 | 671 | 28 |
| 1996-08-14 | vs MIL | 119 | W 8-5 | 63-56 | 2 | 47,480 | David Wells | Jeff D'Amico | Mike Milchin | Ricky Bones | Randy Myers | 707 | 676 | 31 |
| 1996-08-15 | @ OAK | 120 | W 18-5 | 64-56 | 2 | 14,026 | Mike Mussina | Willie Adams | Mike Mussina | Willie Adams | | 725 | 681 | 44 |
| 1996-08-16 | @ OAK | 121 | W 14-3 | 66-56 | 2 | 0 | Scott Erickson | John Wasdin | Scott Erickson | John Wasdin | | 739 | 684 | 55 |
| 1996-08-16 | @ OAK | 122 | W 5-4 | 66-56 | 2 | 15,645 | Rick Krivda | Doug Johns | Randy Myers | Mike Mohler | | 744 | 688 | 56 |
| 1996-08-17 | @ OAK | 123 | L 1-3 | 66-57 | 2 | 20,231 | Rocky Coppinger | Ariel Prieto | Ariel Prieto | Rocky Coppinger | Mark Acre | 745 | 691 | 54 |
| 1996-08-18 | @ OAK | 124 | L 6-9 | 66-58 | 2 | 18,122 | David Wells | Don Wengert | Don Wengert | David Wells | | 751 | 700 | 51 |
| 1996-08-20 | vs SEA | 125 | W 4-1 | 67-58 | 2 | 47,679 | Mike Mussina | Matt Wagner | Mike Mussina | Matt Wagner | Randy Myers | 755 | 701 | 54 |
| 1996-08-21 | vs SEA | 126 | W 10-5 | 68-58 | 2 | 47,198 | Scott Erickson | Sterling Hitchcock | Scott Erickson | Sterling Hitchcock | | 765 | 706 | 59 |
| 1996-08-22 | vs SEA | 127 | L 3-10 | 68-59 | 2 | 47,380 | Rocky Coppinger | Jamie Moyer | Jamie Moyer | Rocky Coppinger | | 768 | 716 | 52 |
| 1996-08-23 | vs CAL | 128 | L 0-2 | 68-60 | 2 | 47,291 | David Wells | Shawn Boskie | Shawn Boskie | David Wells | Troy Percival | 768 | 718 | 50 |
| 1996-08-24 | vs CAL | 129 | W 5-4 | 69-60 | 2 | 46,487 | Mike Mussina | Pep Harris | Mike Mussina | Kyle Abbott | Randy Myers | 773 | 722 | 51 |
| 1996-08-25 | vs CAL | 130 | L 0-13 | 69-61 | 2 | 47,239 | Scott Erickson | Dennis Springer | Dennis Springer | Scott Erickson | | 773 | 735 | 38 |
| 1996-08-26 | vs OAK | 131 | W 12-11 | 70-61 | 2 | 43,361 | Rocky Coppinger | John Wasdin | Randy Myers | Mark Acre | | 785 | 746 | 39 |
| 1996-08-27 | vs OAK | 132 | W 3-1 | 71-61 | 2 | 43,641 | David Wells | Ariel Prieto | David Wells | Ariel Prieto | Randy Myers | 788 | 747 | 41 |
| 1996-08-28 | vs OAK | 133 | L 0-3 | 71-62 | 2 | 45,282 | Mike Mussina | Don Wengert | Don Wengert | Mike Mussina | | 788 | 750 | 38 |
| 1996-08-29 | @ SEA | 134 | L 6-9 | 71-63 | 2 | 24,915 | Jimmy Haynes | Bob Wells | Norm Charlton | Randy Myers | | 794 | 759 | 35 |
| 1996-08-30 | @ SEA | 135 | W 5-2 | 72-63 | 2 | 44,532 | Rocky Coppinger | Sterling Hitchcock | Rocky Coppinger | Sterling Hitchcock | Alan Mills | 799 | 761 | 38 |
| 1996-08-31 | @ SEA | 136 | W 7-6 | 73-63 | 2 | 42,092 | Scott Erickson | Jamie Moyer | Scott Erickson | Chris Bosio | Armando Benitez | 806 | 767 | 39 |
| 1996-09-01 | @ SEA | 137 | L 1-5 | 73-64 | 2 | 50,015 | David Wells | Terry Mulholland | Terry Mulholland | David Wells | | 807 | 772 | 35 |
| 1996-09-02 | @ CAL | 138 | W 12-8 | 74-64 | 2 | 20,287 | Mike Mussina | Shawn Boskie | Mike Mussina | Shawn Boskie | | 819 | 780 | 39 |
| 1996-09-03 | @ CAL | 139 | L 2-10 | 74-65 | 2 | 15,924 | Rocky Coppinger | Pep Harris | Pep Harris | Rocky Coppinger | | 821 | 790 | 31 |
| 1996-09-04 | @ CAL | 140 | W 4-2 | 75-65 | 2 | 18,204 | Scott Erickson | Dennis Springer | Scott Erickson | Dennis Springer | Randy Myers | 825 | 792 | 33 |
| 1996-09-06 | vs DET | 141 | L 4-5 | 75-66 | 2 | 46,708 | David Wells | Felipe Lira | John Cummings | Terry Mathews | | 829 | 797 | 32 |
| 1996-09-07 | vs DET | 142 | W 6-0 | 76-66 | 2 | 47,131 | Mike Mussina | Justin Thompson | Mike Mussina | Justin Thompson | | 835 | 797 | 38 |
| 1996-09-08 | vs DET | 143 | W 6-2 | 77-66 | 2 | 47,082 | Rocky Coppinger | Trever Miller | Alan Mills | Joey Eischen | | 841 | 799 | 42 |
| 1996-09-09 | vs DET | 144 | W 5-4 | 78-66 | 2 | 42,562 | Scott Erickson | Omar Olivares | Scott Erickson | Omar Olivares | Randy Myers | 846 | 803 | 43 |
| 1996-09-10 | vs CHA | 145 | W 5-1 | 79-66 | 2 | 43,320 | David Wells | Kevin Tapani | David Wells | Kevin Tapani | | 851 | 804 | 47 |
| 1996-09-11 | vs CHA | 146 | W 7-6 | 80-66 | 2 | 43,320 | Rick Krivda | Wilson Alvarez | Alan Mills | Roberto Hernandez | | 858 | 810 | 48 |
| 1996-09-12 | vs CHA | 147 | L 3-11 | 80-67 | 2 | 47,342 | Mike Mussina | Alex Fernandez | Alex Fernandez | Mike Mussina | | 861 | 821 | 40 |
| 1996-09-13 | @ DET | 148 | W 7-4 | 81-67 | 2 | 11,178 | Scott Erickson | Trever Miller | Scott Erickson | Trever Miller | Alan Mills | 868 | 825 | 43 |
| 1996-09-14 | @ DET | 149 | W 7-6 | 82-67 | 2 | 15,386 | David Wells | Omar Olivares | Terry Mathews | John Cummings | Randy Myers | 875 | 831 | 44 |
| 1996-09-15 | @ DET | 150 | W 16-6 | 83-67 | 2 | 13,764 | Rocky Coppinger | Todd Van Poppel | Archie Corbin | Todd Van Poppel | | 891 | 837 | 54 |
| 1996-09-18 | @ NYA | 151 | L 2-3 | 83-68 | 2 | 40,775 | Scott Erickson | Andy Pettitte | Mariano Rivera | Alan Mills | | 893 | 840 | 53 |
| 1996-09-19 | @ NYA | 152 | L 3-9 | 84-69 | 2 | 0 | Mike Mussina | Kenny Rogers | Kenny Rogers | Mike Mussina | | 896 | 849 | 47 |
| 1996-09-19 | @ NYA | 153 | W 10-9 | 84-69 | 2 | 54,888 | David Wells | David Cone | Terry Mathews | Mariano Rivera | Randy Myers | 906 | 858 | 48 |
| 1996-09-20 | vs TOR | 154 | L 1-5 | 84-70 | 2 | 47,026 | Rick Krivda | Pat Hentgen | Pat Hentgen | Rick Krivda | Paul Spoljaric | 907 | 863 | 44 |
| 1996-09-21 | vs TOR | 155 | W 6-3 | 85-70 | 2 | 47,270 | Rocky Coppinger | Woody Williams | Rocky Coppinger | Woody Williams | Randy Myers | 913 | 866 | 47 |
| 1996-09-22 | vs TOR | 156 | W 5-4 | 86-70 | 2 | 46,035 | Scott Erickson | Paul Quantrill | Scott Erickson | Huck Flener | Armando Benitez | 918 | 870 | 48 |
| 1996-09-23 | vs MIL | 157 | L 7-8 | 86-71 | 2 | 46,542 | Mike Mussina | Cal Eldred | Doug Jones | Terry Mathews | Mike Fetters | 925 | 878 | 47 |
| 1996-09-24 | @ BOS | 158 | L 8-13 | 86-72 | 2 | 28,557 | David Wells | Tom Gordon | Tom Gordon | David Wells | Pat Mahomes | 933 | 891 | 42 |
| 1996-09-25 | @ BOS | 159 | W 6-2 | 87-72 | 2 | 28,432 | Rick Krivda | Tim Wakefield | Rick Krivda | Tim Wakefield | Armando Benitez | 939 | 893 | 46 |
| 1996-09-26 | @ TOR | 160 | W 4-1 | 88-72 | 2 | 30,141 | Rocky Coppinger | Woody Williams | Rocky Coppinger | Woody Williams | Armando Benitez | 943 | 894 | 49 |
| 1996-09-27 | @ TOR | 161 | L 2-3 | 88-73 | 2 | 30,116 | Scott Erickson | Paul Quantrill | Huck Flener | Scott Erickson | Mike Timlin | 945 | 897 | 48 |
| 1996-09-28 | @ TOR | 162 | W 3-2 | 89-73 | 2 | 36,316 | Mike Mussina | Erik Hanson | Randy Myers | Paul Spoljaric | | 948 | 899 | 49 |
| 1996-09-29 | @ TOR | 163 | L 1-4 | 89-74 | 2 | 38,267 | Nerio Rodriguez | Pat Hentgen | Pat Hentgen | Nerio Rodriguez | Mike Timlin | 949 | 903 | 46 |