| 1995-04-26 | @ KCA | 1 | L 1-5 | 0-1 | 5 | 24,170 | Mike Mussina | Kevin Appier | Kevin Appier | Jamie Moyer | | 1 | 5 | -4 |
| 1995-04-27 | @ MIN | 2 | L 4-7 | 0-2 | 5 | 26,426 | Ben McDonald | Kevin Tapani | Dave Stevens | Brad Pennington | Rick Aguilera | 5 | 12 | -7 |
| 1995-04-28 | @ MIN | 3 | L 9-12 | 0-3 | 5 | 21,259 | Sid Fernandez | Pat Mahomes | Mark Guthrie | Armando Benitez | Rick Aguilera | 14 | 24 | -10 |
| 1995-04-29 | @ MIN | 4 | W 13-7 | 1-3 | 4 | 23,997 | Kevin Brown | LaTroy Hawkins | Kevin Brown | LaTroy Hawkins | | 27 | 31 | -4 |
| 1995-04-30 | @ MIN | 5 | W 6-3 | 2-3 | 4 | 16,302 | Arthur Rhodes | Scott Erickson | Arthur Rhodes | Scott Erickson | Doug Jones | 33 | 34 | -1 |
| 1995-05-01 | vs MIL | 6 | L 0-7 | 2-4 | 5 | 46,523 | Mike Mussina | Ricky Bones | Ricky Bones | Mike Mussina | | 33 | 41 | -8 |
| 1995-05-03 | vs MIL | 7 | L 4-7 | 2-5 | 4 | 33,837 | Ben McDonald | Cal Eldred | Mark Kiefer | Doug Jones | Graeme Lloyd | 37 | 48 | -11 |
| 1995-05-04 | vs MIL | 8 | W 5-2 | 3-5 | 4 | 30,019 | Sid Fernandez | Bob Scanlan | Alan Mills | Jose Mercedes | Doug Jones | 42 | 50 | -8 |
| 1995-05-05 | vs TOR | 9 | W 9-2 | 4-5 | 4 | 37,670 | Kevin Brown | Al Leiter | Kevin Brown | Al Leiter | | 51 | 52 | -1 |
| 1995-05-06 | vs TOR | 10 | L 3-7 | 4-6 | 4 | 40,173 | Arthur Rhodes | Danny Darwin | Danny Darwin | Arthur Rhodes | | 54 | 59 | -5 |
| 1995-05-07 | vs TOR | 11 | W 6-2 | 5-6 | 4 | 44,304 | Mike Mussina | David Cone | Mike Mussina | David Cone | | 60 | 61 | -1 |
| 1995-05-09 | @ BOS | 12 | L 3-4 | 5-7 | 4 | 22,006 | Ben McDonald | Rheal Cormier | Stan Belinda | Armando Benitez | | 63 | 65 | -2 |
| 1995-05-10 | @ BOS | 13 | L 2-6 | 5-8 | 4 | 19,776 | Sid Fernandez | Erik Hanson | Erik Hanson | Sid Fernandez | | 65 | 71 | -6 |
| 1995-05-12 | vs CLE | 14 | L 2-3 | 5-9 | 5 | 40,516 | Kevin Brown | Dennis Martinez | Dennis Martinez | Kevin Brown | Jose Mesa | 67 | 74 | -7 |
| 1995-05-13 | vs CLE | 15 | W 6-1 | 6-9 | 4 | 40,185 | Mike Mussina | Mark Clark | Mike Mussina | Mark Clark | | 73 | 75 | -2 |
| 1995-05-14 | vs CLE | 16 | L 1-3 | 6-10 | 5 | 39,167 | Arthur Rhodes | Orel Hershiser | Orel Hershiser | Arthur Rhodes | Jose Mesa | 74 | 78 | -4 |
| 1995-05-16 | vs DET | 17 | L 8-9 | 6-11 | 5 | 36,249 | Ben McDonald | Sean Bergman | Joe Boever | Doug Jones | Mike Henneman | 82 | 87 | -5 |
| 1995-05-17 | vs DET | 18 | W 7-4 | 7-11 | 5 | 35,187 | Kevin Brown | Buddy Groom | Kevin Brown | Felipe Lira | Armando Benitez | 89 | 91 | -2 |
| 1995-05-18 | vs DET | 19 | W 3-2 | 8-11 | 4 | 39,489 | Mike Mussina | David Wells | Mike Mussina | David Wells | Doug Jones | 92 | 93 | -1 |
| 1995-05-19 | @ NYA | 20 | W 7-5 | 9-11 | 4 | 18,842 | Arthur Rhodes | Jack McDowell | Alan Mills | John Wetteland | Doug Jones | 99 | 98 | 1 |
| 1995-05-20 | @ NYA | 21 | L 2-7 | 9-12 | 4 | 25,237 | Sid Fernandez | Melido Perez | Melido Perez | Sid Fernandez | | 101 | 105 | -4 |
| 1995-05-21 | @ NYA | 22 | L 0-5 | 9-13 | 5 | 25,887 | Ben McDonald | Sterling Hitchcock | Sterling Hitchcock | Ben McDonald | | 101 | 110 | -9 |
| 1995-05-23 | @ OAK | 23 | W 8-1 | 10-13 | 5 | 10,585 | Kevin Brown | Mike Harkey | Kevin Brown | Mike Harkey | | 109 | 111 | -2 |
| 1995-05-24 | @ OAK | 24 | L 3-5 | 10-14 | 5 | 10,003 | Mike Mussina | Dave Stewart | Jim Corsi | Mike Mussina | Dennis Eckersley | 112 | 116 | -4 |
| 1995-05-25 | @ OAK | 25 | L 6-9 | 10-15 | 5 | 12,106 | Arthur Rhodes | Ron Darling | Rick Honeycutt | Armando Benitez | Dennis Eckersley | 118 | 125 | -7 |
| 1995-05-26 | @ SEA | 26 | L 3-8 | 10-16 | 5 | 15,256 | Ben McDonald | Randy Johnson | Randy Johnson | Ben McDonald | | 121 | 133 | -12 |
| 1995-05-27 | @ SEA | 27 | W 11-4 | 11-16 | 5 | 20,797 | Sid Fernandez | Bob Wells | Alan Mills | Bob Wells | | 132 | 137 | -5 |
| 1995-05-28 | @ SEA | 28 | L 2-5 | 11-17 | 5 | 16,785 | Kevin Brown | Chris Bosio | Chris Bosio | Kevin Brown | Bobby Ayala | 134 | 142 | -8 |
| 1995-05-29 | @ CAL | 29 | L 5-6 | 11-18 | 5 | 15,413 | Mike Mussina | Shawn Boskie | Shawn Boskie | Mike Mussina | Lee Smith | 139 | 148 | -9 |
| 1995-05-30 | @ CAL | 30 | W 5-4 | 12-18 | 5 | 13,889 | Jamie Moyer | Mark Langston | Jesse Orosco | Bob Patterson | Doug Jones | 144 | 152 | -8 |
| 1995-05-31 | @ CAL | 31 | W 5-3 | 13-18 | 5 | 14,127 | Ben McDonald | Scott Sanderson | Ben McDonald | Scott Sanderson | Doug Jones | 149 | 155 | -6 |
| 1995-06-02 | vs OAK | 32 | W 2-1 | 14-18 | 4 | 39,313 | Kevin Brown | Steve Ontiveros | Kevin Brown | Rick Honeycutt | Doug Jones | 151 | 156 | -5 |
| 1995-06-03 | vs OAK | 33 | W 9-5 | 15-18 | 2 | 45,056 | Mike Mussina | Mike Harkey | Mike Mussina | Mike Harkey | | 160 | 161 | -1 |
| 1995-06-04 | vs OAK | 34 | L 6-14 | 15-19 | 3 | 37,496 | Sid Fernandez | Dave Stewart | Dave Stewart | Sid Fernandez | | 166 | 175 | -9 |
| 1995-06-05 | vs SEA | 35 | L 0-2 | 15-20 | 3 | 36,732 | Ben McDonald | Randy Johnson | Randy Johnson | Ben McDonald | | 166 | 177 | -11 |
| 1995-06-06 | vs SEA | 36 | W 12-6 | 16-20 | 2 | 33,556 | Jamie Moyer | Dave Fleming | Jamie Moyer | Dave Fleming | | 178 | 183 | -5 |
| 1995-06-07 | vs SEA | 37 | L 2-10 | 16-21 | 2 | 38,407 | Kevin Brown | Chris Bosio | Chris Bosio | Kevin Brown | | 180 | 193 | -13 |
| 1995-06-08 | vs SEA | 38 | W 8-2 | 17-21 | 2 | 40,730 | Mike Mussina | Salomon Torres | Mike Mussina | Salomon Torres | | 188 | 195 | -7 |
| 1995-06-09 | vs CAL | 39 | W 10-4 | 18-21 | 2 | 40,782 | Scott Klingenbeck | Russ Springer | Scott Klingenbeck | Russ Springer | | 198 | 199 | -1 |
| 1995-06-10 | vs CAL | 40 | W 6-2 | 19-21 | 2 | 45,712 | Ben McDonald | Mike Bielecki | Ben McDonald | Mike Bielecki | | 204 | 201 | 3 |
| 1995-06-11 | vs CAL | 41 | L 4-5 | 19-22 | 2 | 45,975 | Jamie Moyer | Mark Langston | Mark Langston | Jamie Moyer | Lee Smith | 208 | 206 | 2 |
| 1995-06-12 | @ CLE | 42 | L 3-4 | 19-23 | 3 | 41,845 | Kevin Brown | Charles Nagy | Charles Nagy | Kevin Brown | Jose Mesa | 211 | 210 | 1 |
| 1995-06-13 | @ CLE | 43 | L 0-11 | 19-24 | 3 | 41,927 | Mike Mussina | Dennis Martinez | Dennis Martinez | Mike Mussina | | 211 | 221 | -10 |
| 1995-06-14 | @ CLE | 44 | L 2-5 | 19-25 | 3 | 41,839 | Scott Klingenbeck | Chad Ogea | Chad Ogea | Scott Klingenbeck | Jose Mesa | 213 | 226 | -13 |
| 1995-06-16 | @ DET | 45 | L 3-5 | 19-26 | 3 | 16,444 | Ben McDonald | Felipe Lira | Felipe Lira | Ben McDonald | Mike Henneman | 216 | 231 | -15 |
| 1995-06-17 | @ DET | 46 | L 3-5 | 19-27 | 4 | 13,195 | Kevin Brown | David Wells | David Wells | Kevin Brown | Joe Boever | 219 | 236 | -17 |
| 1995-06-18 | @ DET | 47 | L 8-10 | 19-28 | 5 | 16,109 | Mike Mussina | Mike Moore | Brian Maxcy | Mike Mussina | Mike Henneman | 227 | 246 | -19 |
| 1995-06-19 | vs NYA | 48 | W 5-4 | 20-28 | 4 | 46,817 | Scott Klingenbeck | Melido Perez | Scott Klingenbeck | Melido Perez | Doug Jones | 232 | 250 | -18 |
| 1995-06-20 | vs NYA | 49 | W 8-7 | 21-28 | 3 | 45,070 | Arthur Rhodes | Sterling Hitchcock | Mike Oquist | Bob Wickman | Doug Jones | 240 | 257 | -17 |
| 1995-06-21 | vs NYA | 50 | L 1-2 | 21-29 | 3 | 46,536 | Jamie Moyer | Andy Pettitte | Andy Pettitte | Jamie Moyer | John Wetteland | 241 | 259 | -18 |
| 1995-06-22 | vs BOS | 51 | L 1-4 | 21-30 | 4 | 45,081 | Kevin Brown | Roger Clemens | Roger Clemens | Kevin Brown | Stan Belinda | 242 | 263 | -21 |
| 1995-06-23 | vs BOS | 52 | W 7-5 | 22-30 | 4 | 46,306 | Mike Mussina | Zane Smith | Mike Mussina | Zane Smith | Mark Lee | 249 | 268 | -19 |
| 1995-06-24 | vs BOS | 53 | L 5-6 | 22-31 | 4 | 47,262 | Scott Klingenbeck | Tim Wakefield | Rheal Cormier | Jesse Orosco | Stan Belinda | 254 | 274 | -20 |
| 1995-06-25 | vs BOS | 54 | W 10-1 | 23-31 | 4 | 47,561 | Arthur Rhodes | Vaughn Eshelman | Arthur Rhodes | Vaughn Eshelman | | 264 | 275 | -11 |
| 1995-06-26 | @ MIL | 55 | W 2-0 | 24-31 | 4 | 11,490 | Jamie Moyer | Angel Miranda | Jamie Moyer | Angel Miranda | Doug Jones | 266 | 275 | -9 |
| 1995-06-27 | @ MIL | 56 | W 11-3 | 25-31 | 4 | 11,436 | John DeSilva | Steve Sparks | John DeSilva | Steve Sparks | | 277 | 278 | -1 |
| 1995-06-28 | @ MIL | 57 | W 4-2 | 26-31 | 4 | 13,568 | Mike Mussina | Ricky Bones | Mike Mussina | Ricky Bones | Doug Jones | 281 | 280 | 1 |
| 1995-06-29 | @ TOR | 58 | L 1-5 | 26-32 | 4 | 40,173 | Sid Fernandez | Juan Guzman | Juan Guzman | Sid Fernandez | | 282 | 285 | -3 |
| 1995-06-30 | @ TOR | 59 | L 5-6 | 26-33 | 4 | 38,416 | Arthur Rhodes | Pat Hentgen | Danny Cox | Terry Clark | | 287 | 291 | -4 |
| 1995-07-01 | @ TOR | 60 | W 6-2 | 27-33 | 4 | 43,375 | Jamie Moyer | Al Leiter | Jamie Moyer | Al Leiter | | 293 | 293 | 0 |
| 1995-07-02 | @ TOR | 61 | W 9-7 | 28-33 | 3 | 42,226 | John DeSilva | Woody Williams | Armando Benitez | Tim Crabtree | Doug Jones | 302 | 300 | 2 |
| 1995-07-03 | vs MIN | 62 | W 9-4 | 29-33 | 3 | 46,560 | Mike Mussina | Kevin Tapani | Mike Mussina | Kevin Tapani | | 311 | 304 | 7 |
| 1995-07-04 | vs MIN | 63 | L 3-6 | 29-34 | 4 | 45,894 | Scott Klingenbeck | Scott Erickson | Scott Erickson | Scott Klingenbeck | | 314 | 310 | 4 |
| 1995-07-05 | vs MIN | 64 | L 2-8 | 29-35 | 4 | 38,845 | Arthur Rhodes | Mike Trombley | Mike Trombley | Arthur Rhodes | | 316 | 318 | -2 |
| 1995-07-06 | @ CHA | 65 | W 2-1 | 30-35 | 3 | 19,868 | Jamie Moyer | Brian Keyser | Jamie Moyer | Tim Fortugno | Doug Jones | 318 | 319 | -1 |
| 1995-07-07 | @ CHA | 66 | W 5-2 | 31-35 | 3 | 23,387 | Rick Krivda | Jim Abbott | Terry Clark | Jim Abbott | Doug Jones | 323 | 321 | 2 |
| 1995-07-08 | @ CHA | 67 | W 5-2 | 32-35 | 3 | 30,593 | Mike Mussina | Jason Bere | Mike Mussina | Jason Bere | | 328 | 323 | 5 |
| 1995-07-09 | @ CHA | 68 | W 11-2 | 33-35 | 3 | 26,176 | Scott Erickson | Alex Fernandez | Scott Erickson | Alex Fernandez | | 339 | 325 | 14 |
| 1995-07-13 | vs KCA | 69 | L 8-9 | 33-36 | 3 | 43,865 | Mike Mussina | Mark Gubicza | Rusty Meacham | Doug Jones | Jeff Montgomery | 347 | 334 | 13 |
| 1995-07-14 | vs KCA | 70 | L 2-7 | 33-37 | 3 | 45,590 | Ben McDonald | Tom Gordon | Tom Gordon | Ben McDonald | | 349 | 341 | 8 |
| 1995-07-15 | vs KCA | 71 | W 9-1 | 34-37 | 3 | 47,159 | Scott Erickson | Kevin Appier | Scott Erickson | Kevin Appier | | 358 | 342 | 16 |
| 1995-07-16 | vs KCA | 72 | W 3-2 | 35-37 | 3 | 45,324 | Jamie Moyer | Melvin Bunch | Jamie Moyer | Melvin Bunch | Doug Jones | 361 | 344 | 17 |
| 1995-07-17 | @ TEX | 73 | W 3-2 | 36-37 | 3 | 26,410 | Kevin Brown | Bob Tewksbury | Mark Lee | Dennis Cook | Doug Jones | 364 | 346 | 18 |
| 1995-07-18 | @ TEX | 74 | W 4-2 | 37-37 | 2 | 31,837 | Mike Mussina | Roger Pavlik | Mike Mussina | Roger Pavlik | Doug Jones | 368 | 348 | 20 |
| 1995-07-19 | @ MIN | 75 | L 3-5 | 37-38 | 2 | 12,786 | Ben McDonald | Brad Radke | Brad Radke | Ben McDonald | Dave Stevens | 371 | 353 | 18 |
| 1995-07-20 | @ MIN | 76 | L 2-5 | 37-39 | 2 | 16,025 | Scott Erickson | Frankie Rodriguez | Frankie Rodriguez | Scott Erickson | Dave Stevens | 373 | 358 | 15 |
| 1995-07-21 | @ KCA | 77 | W 10-6 | 38-39 | 2 | 22,924 | Jamie Moyer | Melvin Bunch | Mike Oquist | Melvin Bunch | | 383 | 364 | 19 |
| 1995-07-22 | @ KCA | 78 | L 3-5 | 38-40 | 2 | 25,697 | Kevin Brown | Mark Gubicza | Billy Brewer | Arthur Rhodes | Jeff Montgomery | 386 | 369 | 17 |
| 1995-07-23 | @ KCA | 79 | W 6-2 | 39-40 | 2 | 21,657 | Mike Mussina | Tom Gordon | Mike Mussina | Tom Gordon | | 392 | 371 | 21 |
| 1995-07-25 | vs TEX | 80 | W 4-3 | 40-40 | 3 | 40,961 | Scott Erickson | Kenny Rogers | Jesse Orosco | Roger McDowell | | 396 | 374 | 22 |
| 1995-07-26 | vs TEX | 81 | W 7-6 | 41-40 | 2 | 41,159 | Jamie Moyer | Dennis Cook | Jamie Moyer | Dennis Cook | Doug Jones | 403 | 380 | 23 |
| 1995-07-27 | vs TEX | 82 | L 1-2 | 41-41 | 3 | 44,832 | Kevin Brown | Roger Pavlik | Ed Vosberg | Jesse Orosco | Jeff Russell | 404 | 382 | 22 |
| 1995-07-28 | vs CHA | 83 | W 4-3 | 42-41 | 2 | 47,353 | Mike Mussina | Wilson Alvarez | Mike Mussina | Wilson Alvarez | Doug Jones | 408 | 385 | 23 |
| 1995-07-29 | vs CHA | 84 | L 4-7 | 42-42 | 3 | 47,313 | Rick Krivda | Mike Bertotti | Mike Bertotti | Mike Oquist | Roberto Hernandez | 412 | 392 | 20 |
| 1995-07-30 | vs CHA | 85 | W 8-3 | 43-42 | 3 | 47,290 | Scott Erickson | Jason Bere | Scott Erickson | Jason Bere | | 420 | 395 | 25 |
| 1995-07-31 | vs TOR | 86 | L 3-6 | 43-43 | 3 | 41,937 | Jamie Moyer | Pat Hentgen | Pat Hentgen | Jamie Moyer | Ricardo Jordan | 423 | 401 | 22 |
| 1995-08-01 | vs TOR | 87 | L 10-12 | 43-44 | 3 | 41,394 | Kevin Brown | Edwin Hurtado | Ken Robinson | Doug Jones | Tony Castillo | 433 | 413 | 20 |
| 1995-08-02 | vs TOR | 88 | W 1-0 | 44-44 | 3 | 40,023 | Mike Mussina | Paul Menhart | Mike Mussina | Paul Menhart | | 434 | 413 | 21 |
| 1995-08-03 | vs TOR | 89 | L 2-8 | 44-45 | 3 | 43,325 | Rick Krivda | Giovanni Carrara | Ricardo Jordan | Terry Clark | | 436 | 421 | 15 |
| 1995-08-04 | vs MIL | 90 | L 4-12 | 44-46 | 3 | 44,598 | Scott Erickson | Scott Karl | Scott Karl | Scott Erickson | | 440 | 433 | 7 |
| 1995-08-05 | vs MIL | 91 | W 6-5 | 45-46 | 3 | 45,750 | Jamie Moyer | Steve Sparks | Terry Clark | Mike Fetters | | 446 | 438 | 8 |
| 1995-08-06 | vs MIL | 92 | L 2-3 | 45-47 | 3 | 45,790 | Kevin Brown | Brian Givens | Mike Ignasiak | Kevin Brown | Mike Fetters | 448 | 441 | 7 |
| 1995-08-07 | @ NYA | 93 | L 0-3 | 45-48 | 3 | 31,313 | Mike Mussina | Jack McDowell | Jack McDowell | Mike Mussina | | 448 | 444 | 4 |
| 1995-08-08 | @ NYA | 94 | L 4-11 | 45-49 | 3 | 33,078 | Rick Krivda | David Cone | David Cone | Rick Krivda | | 452 | 455 | -3 |
| 1995-08-09 | @ NYA | 95 | W 7-2 | 46-49 | 3 | 36,333 | Jamie Moyer | Scott Kamieniecki | Jamie Moyer | Scott Kamieniecki | | 459 | 457 | 2 |
| 1995-08-10 | @ BOS | 96 | L 1-11 | 46-50 | 3 | 33,588 | Scott Erickson | Rheal Cormier | Rheal Cormier | Scott Erickson | | 460 | 468 | -8 |
| 1995-08-11 | @ BOS | 97 | L 4-5 | 46-51 | 3 | 33,143 | Kevin Brown | Mike Maddux | Rick Aguilera | Terry Clark | | 464 | 473 | -9 |
| 1995-08-12 | @ BOS | 98 | L 0-7 | 46-52 | 3 | 34,234 | Mike Mussina | Roger Clemens | Roger Clemens | Mike Mussina | | 464 | 480 | -16 |
| 1995-08-13 | @ BOS | 99 | L 2-3 | 46-53 | 3 | 34,158 | Rick Krivda | Tim Wakefield | Tim Wakefield | Rick Krivda | Stan Belinda | 466 | 483 | -17 |
| 1995-08-14 | vs CLE | 100 | L 6-9 | 46-54 | 3 | 47,198 | Jamie Moyer | Ken Hill | Paul Assenmacher | Armando Benitez | Jose Mesa | 472 | 492 | -20 |
| 1995-08-15 | vs CLE | 101 | W 8-3 | 47-54 | 3 | 46,346 | Scott Erickson | Charles Nagy | Scott Erickson | Charles Nagy | | 480 | 495 | -15 |
| 1995-08-16 | vs CLE | 102 | L 5-8 | 47-55 | 3 | 47,140 | Kevin Brown | Orel Hershiser | Orel Hershiser | Kevin Brown | Jose Mesa | 485 | 503 | -18 |
| 1995-08-17 | vs KCA | 103 | L 2-3 | 47-56 | 3 | 46,394 | Mike Mussina | Kevin Appier | Gregg Olson | Jesse Orosco | Jeff Montgomery | 487 | 506 | -19 |
| 1995-08-18 | @ OAK | 104 | W 8-4 | 48-56 | 3 | 12,695 | Rick Krivda | Ariel Prieto | Rick Krivda | Ariel Prieto | Terry Clark | 495 | 510 | -15 |
| 1995-08-19 | @ OAK | 105 | W 12-6 | 49-56 | 3 | 15,670 | Jamie Moyer | Steve Wojciechowski | Jamie Moyer | Steve Wojciechowski | | 507 | 516 | -9 |
| 1995-08-20 | @ OAK | 106 | L 3-6 | 49-57 | 3 | 18,455 | Scott Erickson | Doug Johns | Doug Johns | Scott Erickson | Dennis Eckersley | 510 | 522 | -12 |
| 1995-08-21 | @ SEA | 107 | L 0-6 | 49-58 | 3 | 32,525 | Kevin Brown | Randy Johnson | Jeff Nelson | Armando Benitez | | 510 | 528 | -18 |
| 1995-08-22 | @ SEA | 108 | W 2-1 | 50-58 | 3 | 13,631 | Mike Mussina | Tim Belcher | Mike Mussina | Tim Belcher | Doug Jones | 512 | 529 | -17 |
| 1995-08-23 | @ SEA | 109 | W 7-1 | 51-58 | 3 | 14,937 | Rick Krivda | Bob Wolcott | Rick Krivda | Bob Wolcott | Armando Benitez | 519 | 530 | -11 |
| 1995-08-24 | @ CAL | 110 | L 4-6 | 51-59 | 3 | 22,796 | Jamie Moyer | Chuck Finley | Chuck Finley | Arthur Rhodes | Lee Smith | 523 | 536 | -13 |
| 1995-08-25 | @ CAL | 111 | W 11-2 | 52-59 | 3 | 26,960 | Scott Erickson | Mark Langston | Scott Erickson | Mark Langston | | 534 | 538 | -4 |
| 1995-08-26 | @ CAL | 112 | W 5-2 | 53-59 | 3 | 61,082 | Kevin Brown | Brian Anderson | Kevin Brown | Brian Anderson | | 539 | 540 | -1 |
| 1995-08-27 | @ CAL | 113 | W 4-0 | 54-59 | 3 | 26,732 | Mike Mussina | Mike Harkey | Mike Mussina | Mike Harkey | | 543 | 540 | 3 |
| 1995-08-29 | vs OAK | 114 | L 1-3 | 54-60 | 3 | 41,512 | Rick Krivda | Steve Ontiveros | Carlos Reyes | Terry Clark | Dennis Eckersley | 544 | 543 | 1 |
| 1995-08-30 | vs OAK | 115 | L 2-7 | 54-61 | 3 | 40,013 | Jamie Moyer | Doug Johns | Doug Johns | Jamie Moyer | Dennis Eckersley | 546 | 550 | -4 |
| 1995-08-31 | vs OAK | 116 | L 7-8 | 54-62 | 3 | 38,424 | Scott Erickson | Todd Stottlemyre | Carlos Reyes | Terry Clark | Dennis Eckersley | 553 | 558 | -5 |
| 1995-09-01 | vs SEA | 117 | L 3-4 | 54-63 | 3 | 43,447 | Mike Mussina | Tim Belcher | Tim Belcher | Mike Mussina | Norm Charlton | 556 | 562 | -6 |
| 1995-09-02 | vs SEA | 118 | W 3-2 | 55-63 | 3 | 46,731 | Kevin Brown | Chris Bosio | Kevin Brown | Chris Bosio | Doug Jones | 559 | 564 | -5 |
| 1995-09-03 | vs SEA | 119 | L 6-9 | 55-64 | 3 | 46,269 | Rick Krivda | Andy Benes | Rafael Carmona | Rick Krivda | Norm Charlton | 565 | 573 | -8 |
| 1995-09-04 | vs CAL | 120 | L 3-5 | 55-65 | 3 | 42,086 | Jamie Moyer | Jim Abbott | Jim Abbott | Jamie Moyer | Lee Smith | 568 | 578 | -10 |
| 1995-09-05 | vs CAL | 121 | W 8-0 | 56-65 | 3 | 46,804 | Scott Erickson | Brian Anderson | Scott Erickson | Brian Anderson | | 576 | 578 | -2 |
| 1995-09-06 | vs CAL | 122 | W 4-2 | 57-65 | 3 | 46,272 | Mike Mussina | Shawn Boskie | Mike Mussina | Shawn Boskie | Jesse Orosco | 580 | 580 | 0 |
| 1995-09-08 | @ CLE | 123 | L 2-3 | 57-66 | 3 | 41,656 | Kevin Brown | Orel Hershiser | Orel Hershiser | Kevin Brown | Jose Mesa | 582 | 583 | -1 |
| 1995-09-09 | @ CLE | 124 | L 1-2 | 57-67 | 3 | 41,729 | Rick Krivda | Chad Ogea | Chad Ogea | Rick Krivda | Jose Mesa | 583 | 585 | -2 |
| 1995-09-10 | @ CLE | 125 | L 3-5 | 57-68 | 3 | 41,647 | Scott Erickson | Mark Clark | Julian Tavarez | Jesse Orosco | Jose Mesa | 586 | 590 | -4 |
| 1995-09-11 | vs BOS | 126 | W 10-7 | 58-68 | 3 | 40,585 | Mike Mussina | Roger Clemens | Mark Lee | Eric Gunderson | Doug Jones | 596 | 597 | -1 |
| 1995-09-12 | vs BOS | 127 | W 6-5 | 59-68 | 3 | 40,282 | Kevin Brown | Rheal Cormier | Mike Hartley | Joe Hudson | Jesse Orosco | 602 | 602 | 0 |
| 1995-09-13 | vs BOS | 128 | L 0-2 | 59-69 | 3 | 41,536 | Jimmy Haynes | Tim Wakefield | Tim Wakefield | Jimmy Haynes | Rick Aguilera | 602 | 604 | -2 |
| 1995-09-14 | vs NYA | 129 | L 4-5 | 59-70 | 3 | 44,289 | Rick Krivda | Andy Pettitte | Andy Pettitte | Rick Krivda | John Wetteland | 606 | 609 | -3 |
| 1995-09-15 | vs NYA | 130 | W 8-1 | 60-70 | 3 | 47,436 | Scott Erickson | Sterling Hitchcock | Scott Erickson | Sterling Hitchcock | | 614 | 610 | 4 |
| 1995-09-16 | vs NYA | 131 | L 5-6 | 60-71 | 3 | 46,891 | Mike Mussina | Jack McDowell | Jack McDowell | Mike Mussina | Bob Wickman | 619 | 616 | 3 |
| 1995-09-17 | vs NYA | 132 | W 2-0 | 61-71 | 3 | 46,027 | Kevin Brown | Scott Kamieniecki | Kevin Brown | Scott Kamieniecki | Jesse Orosco | 621 | 616 | 5 |
| 1995-09-18 | @ DET | 133 | W 6-2 | 62-71 | 3 | 12,637 | Jimmy Haynes | Felipe Lira | Jimmy Haynes | Felipe Lira | | 627 | 618 | 9 |
| 1995-09-19 | @ DET | 134 | L 4-7 | 62-72 | 3 | 9,647 | Rick Krivda | Sean Bergman | Mike Myers | Rick Krivda | Dwayne Henry | 631 | 625 | 6 |
| 1995-09-20 | @ DET | 135 | W 6-3 | 63-72 | 3 | 8,397 | Scott Erickson | Clint Sodowsky | Scott Erickson | Clint Sodowsky | | 637 | 628 | 9 |
| 1995-09-21 | @ DET | 136 | W 13-1 | 64-72 | 3 | 14,803 | Mike Mussina | C.J. Nitkowski | Mike Mussina | John Doherty | | 650 | 629 | 21 |
| 1995-09-22 | @ MIL | 137 | W 10-3 | 65-72 | 3 | 10,042 | Kevin Brown | Brian Givens | Kevin Brown | Brian Givens | | 660 | 632 | 28 |
| 1995-09-23 | @ MIL | 138 | W 9-3 | 66-72 | 3 | 21,074 | Jimmy Haynes | Ricky Bones | Jimmy Haynes | Ricky Bones | | 669 | 635 | 34 |
| 1995-09-24 | @ MIL | 139 | L 1-5 | 66-73 | 3 | 15,181 | Rick Krivda | Steve Sparks | Steve Sparks | Rick Krivda | | 670 | 640 | 30 |
| 1995-09-26 | @ TOR | 140 | W 5-0 | 67-73 | 3 | 35,414 | Mike Mussina | Pat Hentgen | Mike Mussina | Pat Hentgen | | 675 | 640 | 35 |
| 1995-09-27 | @ TOR | 141 | W 7-0 | 68-73 | 3 | 35,019 | Scott Erickson | Paul Menhart | Scott Erickson | Paul Menhart | | 682 | 640 | 42 |
| 1995-09-29 | vs DET | 142 | W 6-0 | 69-73 | 3 | 46,512 | Kevin Brown | Felipe Lira | Kevin Brown | Felipe Lira | | 688 | 640 | 48 |
| 1995-09-30 | vs DET | 143 | W 12-0 | 70-73 | 3 | 47,132 | Ben McDonald | Sean Bergman | Ben McDonald | Sean Bergman | | 700 | 640 | 60 |
| 1995-10-01 | vs DET | 144 | W 4-0 | 71-73 | 3 | 45,760 | Mike Mussina | Clint Sodowsky | Mike Mussina | Clint Sodowsky | | 704 | 640 | 64 |