| 1995-04-26 | @ CAL | 1 | W 5-4 | 1-0 | 2 | 51,145 | Mike Moore | Chuck Finley | Mike Moore | Chuck Finley | Buddy Groom | 5 | 4 | 1 |
| 1995-04-27 | @ SEA | 2 | L 0-3 | 1-1 | 4 | 34,656 | Sean Bergman | Randy Johnson | Randy Johnson | Sean Bergman | Bobby Ayala | 5 | 7 | -2 |
| 1995-04-28 | @ SEA | 3 | L 2-9 | 1-2 | 4 | 19,336 | John Doherty | Chris Bosio | Chris Bosio | John Doherty | | 7 | 16 | -9 |
| 1995-04-29 | @ SEA | 4 | L 1-11 | 1-3 | 5 | 27,264 | David Wells | Dave Fleming | Dave Fleming | David Wells | Jim Converse | 8 | 27 | -19 |
| 1995-04-30 | @ SEA | 5 | W 10-1 | 2-3 | 5 | 19,743 | Mike Moore | Bob Wells | Mike Moore | Bob Wells | | 18 | 28 | -10 |
| 1995-05-02 | vs CLE | 6 | L 1-11 | 2-4 | 5 | 39,398 | Sean Bergman | Dennis Martinez | Dennis Martinez | Sean Bergman | | 19 | 39 | -20 |
| 1995-05-03 | vs CLE | 7 | L 7-14 | 2-5 | 5 | 29,996 | John Doherty | Mark Clark | Mark Clark | John Doherty | | 26 | 53 | -27 |
| 1995-05-04 | vs CLE | 8 | W 4-3 | 3-5 | 5 | 28,846 | David Wells | Orel Hershiser | David Wells | Orel Hershiser | Mike Henneman | 30 | 56 | -26 |
| 1995-05-05 | vs BOS | 9 | L 7-10 | 3-6 | 5 | 10,041 | Mike Moore | Frankie Rodriguez | Derek Lilliquist | Felipe Lira | Ken Ryan | 37 | 66 | -29 |
| 1995-05-06 | vs BOS | 10 | L 3-5 | 3-7 | 5 | 16,564 | Sean Bergman | Aaron Sele | Aaron Sele | Sean Bergman | Stan Belinda | 40 | 71 | -31 |
| 1995-05-07 | vs BOS | 11 | L 1-12 | 3-8 | 5 | 10,752 | Buddy Groom | Vaughn Eshelman | Vaughn Eshelman | Buddy Groom | | 41 | 83 | -42 |
| 1995-05-09 | @ MIL | 12 | W 4-2 | 4-8 | 5 | 7,298 | David Wells | Cal Eldred | John Doherty | Graeme Lloyd | | 45 | 85 | -40 |
| 1995-05-10 | @ MIL | 13 | L 2-13 | 4-9 | 5 | 7,129 | Mike Moore | Bob Scanlan | Bob Scanlan | Mike Moore | | 47 | 98 | -51 |
| 1995-05-11 | @ MIL | 14 | W 8-0 | 5-9 | 5 | 11,078 | Sean Bergman | Bill Wegman | Sean Bergman | Bill Wegman | | 55 | 98 | -43 |
| 1995-05-12 | @ TEX | 15 | W 6-1 | 6-9 | 4 | 21,393 | Buddy Groom | Kevin Gross | Buddy Groom | Kevin Gross | | 61 | 99 | -38 |
| 1995-05-13 | @ TEX | 16 | L 3-5 | 6-10 | 5 | 31,160 | David Wells | Roger Pavlik | Roger Pavlik | David Wells | Jeff Russell | 64 | 104 | -40 |
| 1995-05-14 | @ TEX | 17 | W 8-3 | 7-10 | 4 | 21,182 | Mike Moore | Rick Helling | Mike Moore | Rick Helling | | 72 | 107 | -35 |
| 1995-05-16 | @ BAL | 18 | W 9-8 | 8-10 | 4 | 36,249 | Sean Bergman | Ben McDonald | Joe Boever | Doug Jones | Mike Henneman | 81 | 115 | -34 |
| 1995-05-17 | @ BAL | 19 | L 4-7 | 8-11 | 4 | 35,187 | Buddy Groom | Kevin Brown | Kevin Brown | Felipe Lira | Armando Benitez | 85 | 122 | -37 |
| 1995-05-18 | @ BAL | 20 | L 2-3 | 8-12 | 5 | 39,489 | David Wells | Mike Mussina | Mike Mussina | David Wells | Doug Jones | 87 | 125 | -38 |
| 1995-05-19 | vs TOR | 21 | L 2-4 | 8-13 | 5 | 18,558 | Mike Moore | David Cone | David Cone | Mike Moore | | 89 | 129 | -40 |
| 1995-05-20 | vs TOR | 22 | W 10-6 | 9-13 | 5 | 18,888 | Brian Bohanon | Pat Hentgen | John Doherty | Pat Hentgen | | 99 | 135 | -36 |
| 1995-05-21 | vs TOR | 23 | W 2-1 | 10-13 | 3 | 19,144 | Sean Bergman | Al Leiter | Joe Boever | Danny Cox | Mike Henneman | 101 | 136 | -35 |
| 1995-05-22 | vs SEA | 24 | W 10-8 | 11-13 | 3 | 9,167 | Buddy Groom | Bob Wells | Joe Boever | Rafael Carmona | Mike Henneman | 111 | 144 | -33 |
| 1995-05-23 | vs MIN | 25 | W 6-4 | 12-13 | 3 | 8,042 | David Wells | Eddie Guardado | David Wells | Eddie Guardado | | 117 | 148 | -31 |
| 1995-05-24 | vs MIN | 26 | W 14-3 | 13-13 | 3 | 8,608 | Mike Moore | Brad Radke | Mike Moore | Brad Radke | | 131 | 151 | -20 |
| 1995-05-25 | vs MIN | 27 | L 3-4 | 13-14 | 3 | 17,111 | Brian Bohanon | Scott Erickson | Mark Guthrie | Joe Boever | Rick Aguilera | 134 | 155 | -21 |
| 1995-05-26 | vs CHA | 28 | W 8-7 | 14-14 | 2 | 15,551 | Sean Bergman | Jim Abbott | Brian Maxcy | Roberto Hernandez | | 142 | 162 | -20 |
| 1995-05-27 | vs CHA | 29 | L 0-1 | 14-15 | 2 | 14,425 | Felipe Lira | Jason Bere | Jason Bere | Felipe Lira | Roberto Hernandez | 142 | 163 | -21 |
| 1995-05-28 | vs CHA | 30 | L 12-14 | 14-16 | 3 | 10,813 | David Wells | James Baldwin | Scott Radinsky | Buddy Groom | Roberto Hernandez | 154 | 177 | -23 |
| 1995-05-29 | @ TOR | 31 | L 4-5 | 14-17 | 3 | 39,294 | Mike Moore | David Cone | David Cone | Mike Moore | Mike Timlin | 158 | 182 | -24 |
| 1995-05-30 | @ TOR | 32 | W 8-6 | 15-17 | 2 | 39,711 | Brian Bohanon | Paul Menhart | Felipe Lira | Danny Cox | Mike Henneman | 166 | 188 | -22 |
| 1995-05-31 | @ TOR | 33 | L 3-5 | 15-18 | 2 | 41,232 | Sean Bergman | Pat Hentgen | Pat Hentgen | John Doherty | | 169 | 193 | -24 |
| 1995-06-02 | @ CHA | 34 | L 4-5 | 15-19 | 3 | 19,090 | David Wells | Brian Keyser | Roberto Hernandez | Mike Henneman | | 173 | 198 | -25 |
| 1995-06-03 | @ CHA | 35 | L 6-10 | 15-20 | 4 | 27,220 | Mike Moore | Wilson Alvarez | Kirk McCaskill | Joe Boever | | 179 | 208 | -29 |
| 1995-06-04 | @ CHA | 36 | W 8-5 | 16-20 | 2 | 21,673 | Brian Bohanon | Alex Fernandez | Brian Maxcy | Roberto Hernandez | Mike Henneman | 187 | 213 | -26 |
| 1995-06-05 | @ CLE | 37 | L 0-8 | 16-21 | 2 | 34,615 | Sean Bergman | Orel Hershiser | Orel Hershiser | Sean Bergman | | 187 | 221 | -34 |
| 1995-06-06 | @ CLE | 38 | L 3-4 | 16-22 | 3 | 36,115 | Felipe Lira | Buddy Black | Julian Tavarez | Joe Boever | Jose Mesa | 190 | 225 | -35 |
| 1995-06-07 | @ CLE | 39 | L 2-3 | 16-23 | 5 | 36,363 | David Wells | Charles Nagy | Eric Plunk | Brian Maxcy | | 192 | 228 | -36 |
| 1995-06-08 | @ MIN | 40 | L 2-9 | 16-24 | 5 | 11,304 | Mike Moore | Kevin Tapani | Kevin Tapani | Mike Moore | | 194 | 237 | -43 |
| 1995-06-09 | @ MIN | 41 | W 6-5 | 17-24 | 4 | 13,980 | Brian Bohanon | Pat Mahomes | John Doherty | Mark Guthrie | Mike Henneman | 200 | 242 | -42 |
| 1995-06-10 | @ MIN | 42 | W 7-5 | 18-24 | 3 | 17,516 | Sean Bergman | Mike Trombley | Sean Bergman | Mike Trombley | Mike Henneman | 207 | 247 | -40 |
| 1995-06-11 | @ MIN | 43 | W 8-2 | 19-24 | 3 | 15,364 | Felipe Lira | Brad Radke | Felipe Lira | Brad Radke | Joe Boever | 215 | 249 | -34 |
| 1995-06-12 | vs NYA | 44 | W 6-1 | 20-24 | 2 | 14,135 | David Wells | Andy Pettitte | David Wells | Andy Pettitte | | 221 | 250 | -29 |
| 1995-06-13 | vs NYA | 45 | L 4-10 | 20-25 | 2 | 11,800 | Mike Moore | Jack McDowell | Jack McDowell | Mike Moore | | 225 | 260 | -35 |
| 1995-06-14 | vs NYA | 46 | L 3-12 | 20-26 | 2 | 12,254 | Pat Ahearne | Melido Perez | Melido Perez | Pat Ahearne | | 228 | 272 | -44 |
| 1995-06-15 | vs NYA | 47 | W 9-2 | 21-26 | 2 | 9,793 | Sean Bergman | Brian Boehringer | Sean Bergman | Brian Boehringer | | 237 | 274 | -37 |
| 1995-06-16 | vs BAL | 48 | W 5-3 | 22-26 | 2 | 16,444 | Felipe Lira | Ben McDonald | Felipe Lira | Ben McDonald | Mike Henneman | 242 | 277 | -35 |
| 1995-06-17 | vs BAL | 49 | W 5-3 | 23-26 | 2 | 13,195 | David Wells | Kevin Brown | David Wells | Kevin Brown | Joe Boever | 247 | 280 | -33 |
| 1995-06-18 | vs BAL | 50 | W 10-8 | 24-26 | 2 | 16,109 | Mike Moore | Mike Mussina | Brian Maxcy | Mike Mussina | Mike Henneman | 257 | 288 | -31 |
| 1995-06-19 | vs TEX | 51 | L 4-6 | 24-27 | 2 | 11,215 | Pat Ahearne | Kevin Gross | Kevin Gross | Pat Ahearne | Jeff Russell | 261 | 294 | -33 |
| 1995-06-20 | vs TEX | 52 | L 6-8 | 24-28 | 2 | 10,874 | Sean Bergman | Darren Oliver | Darren Oliver | Sean Bergman | Jeff Russell | 267 | 302 | -35 |
| 1995-06-21 | vs TEX | 53 | W 1-0 | 25-28 | 2 | 16,487 | Felipe Lira | Bob Tewksbury | Felipe Lira | Bob Tewksbury | Mike Henneman | 268 | 302 | -34 |
| 1995-06-23 | vs MIL | 54 | W 5-2 | 26-28 | 2 | 15,920 | David Wells | Ricky Bones | David Wells | Ricky Bones | Mike Henneman | 273 | 304 | -31 |
| 1995-06-24 | vs MIL | 55 | W 7-2 | 27-28 | 2 | 12,062 | Mike Moore | Brian Givens | Mike Moore | Brian Givens | Joe Boever | 280 | 306 | -26 |
| 1995-06-25 | vs MIL | 56 | W 6-3 | 28-28 | 2 | 15,263 | Sean Bergman | Sid Roberson | Brian Maxcy | Ron Rightnowar | Mike Henneman | 286 | 309 | -23 |
| 1995-06-26 | @ NYA | 57 | L 3-7 | 28-29 | 2 | 18,353 | Felipe Lira | Andy Pettitte | Andy Pettitte | Felipe Lira | | 289 | 316 | -27 |
| 1995-06-27 | @ NYA | 58 | L 1-7 | 28-30 | 2 | 19,765 | Brian Bohanon | Scott Bankhead | Bob Macdonald | Brian Bohanon | Joe Ausanio | 290 | 323 | -33 |
| 1995-06-28 | @ NYA | 59 | W 8-4 | 29-30 | 2 | 24,673 | David Wells | Jack McDowell | David Wells | Jack McDowell | | 298 | 327 | -29 |
| 1995-06-29 | @ BOS | 60 | L 1-7 | 29-31 | 2 | 28,457 | Mike Moore | Tim Wakefield | Tim Wakefield | Mike Moore | | 299 | 334 | -35 |
| 1995-06-30 | @ BOS | 61 | W 7-6 | 30-31 | 2 | 31,349 | Pat Ahearne | Vaughn Eshelman | Joe Boever | Ken Ryan | Mike Henneman | 306 | 340 | -34 |
| 1995-07-01 | @ BOS | 62 | W 11-2 | 31-31 | 2 | 33,359 | Felipe Lira | Erik Hanson | Felipe Lira | Erik Hanson | John Doherty | 317 | 342 | -25 |
| 1995-07-02 | @ BOS | 63 | L 11-12 | 31-32 | 2 | 34,344 | Brian Bohanon | Roger Clemens | Stan Belinda | Joe Boever | | 328 | 354 | -26 |
| 1995-07-03 | vs SEA | 64 | W 4-2 | 32-32 | 2 | 23,780 | David Wells | Chris Bosio | David Wells | Chris Bosio | Mike Henneman | 332 | 356 | -24 |
| 1995-07-04 | vs SEA | 65 | W 9-8 | 33-32 | 2 | 20,188 | Mike Moore | Salomon Torres | Mike Christopher | Bobby Ayala | | 341 | 364 | -23 |
| 1995-07-05 | vs SEA | 66 | W 8-6 | 34-32 | 2 | 17,224 | Felipe Lira | Dave Fleming | Mike Christopher | Rafael Carmona | Mike Henneman | 349 | 370 | -21 |
| 1995-07-06 | vs KCA | 67 | W 12-5 | 35-32 | 2 | 11,464 | Brian Bohanon | Chris Haney | John Doherty | Chris Haney | Kevin Wickander | 361 | 375 | -14 |
| 1995-07-07 | vs KCA | 68 | W 3-1 | 36-32 | 2 | 19,968 | David Wells | Kevin Appier | David Wells | Kevin Appier | | 364 | 376 | -12 |
| 1995-07-08 | vs KCA | 69 | L 1-4 | 36-33 | 2 | 36,905 | Mike Moore | Mark Gubicza | Mark Gubicza | Mike Moore | Jeff Montgomery | 365 | 380 | -15 |
| 1995-07-09 | vs KCA | 70 | W 4-2 | 37-33 | 2 | 18,110 | Felipe Lira | Tom Gordon | Felipe Lira | Tom Gordon | Mike Henneman | 369 | 382 | -13 |
| 1995-07-13 | vs CAL | 71 | L 5-8 | 37-34 | 2 | 13,837 | Jose Lima | Mark Langston | Troy Percival | Joe Boever | Lee Smith | 374 | 390 | -16 |
| 1995-07-14 | vs CAL | 72 | L 3-7 | 37-35 | 2 | 19,204 | Felipe Lira | Russ Springer | Bob Patterson | Felipe Lira | Troy Percival | 377 | 397 | -20 |
| 1995-07-16 | vs CAL | 73 | L 4-6 | 37-37 | 2 | 0 | David Wells | Chuck Finley | Chuck Finley | Joe Boever | Lee Smith | 381 | 403 | -22 |
| 1995-07-16 | vs CAL | 74 | L 6-13 | 37-37 | 2 | 21,186 | Mike Moore | Mike Bielecki | Mike James | Mike Moore | | 387 | 416 | -29 |
| 1995-07-17 | @ SEA | 75 | L 6-10 | 37-38 | 2 | 14,358 | Sean Bergman | Bill Krueger | Bobby Ayala | Buddy Groom | | 393 | 426 | -33 |
| 1995-07-18 | @ SEA | 76 | L 6-10 | 37-39 | 3 | 14,667 | Jose Lima | Tim Belcher | Tim Belcher | Jose Lima | | 399 | 436 | -37 |
| 1995-07-19 | @ OAK | 77 | L 1-2 | 37-40 | 3 | 11,672 | Felipe Lira | Ariel Prieto | Ariel Prieto | John Doherty | Rick Honeycutt | 400 | 438 | -38 |
| 1995-07-20 | @ OAK | 78 | L 3-6 | 37-41 | 3 | 13,697 | Mike Moore | Ron Darling | Ron Darling | Mike Moore | Dennis Eckersley | 403 | 444 | -41 |
| 1995-07-21 | @ CAL | 79 | W 4-3 | 38-41 | 3 | 21,731 | David Wells | Mike Harkey | David Wells | John Habyan | Mike Henneman | 407 | 447 | -40 |
| 1995-07-22 | @ CAL | 80 | L 3-13 | 38-42 | 4 | 28,429 | Sean Bergman | Brian Anderson | Brian Anderson | Sean Bergman | | 410 | 460 | -50 |
| 1995-07-23 | @ CAL | 81 | L 2-13 | 38-43 | 4 | 18,948 | Jose Lima | Mark Langston | Mark Langston | Jose Lima | | 412 | 473 | -61 |
| 1995-07-25 | vs OAK | 82 | W 6-3 | 39-43 | 4 | 14,560 | Felipe Lira | Ron Darling | Felipe Lira | Ron Darling | | 418 | 476 | -58 |
| 1995-07-26 | vs OAK | 83 | W 10-4 | 40-43 | 4 | 14,284 | David Wells | Carlos Reyes | David Wells | Carlos Reyes | | 428 | 480 | -52 |
| 1995-07-27 | vs OAK | 84 | L 3-11 | 40-44 | 4 | 18,836 | Mike Moore | Todd Stottlemyre | Todd Stottlemyre | Mike Moore | | 431 | 491 | -60 |
| 1995-07-28 | @ KCA | 85 | L 3-4 | 40-45 | 4 | 18,070 | Sean Bergman | Tom Gordon | Jeff Montgomery | John Doherty | | 434 | 495 | -61 |
| 1995-07-29 | @ KCA | 86 | L 4-5 | 40-46 | 4 | 20,157 | Jose Lima | Melvin Bunch | Hipolito Pichardo | John Doherty | | 438 | 500 | -62 |
| 1995-07-30 | @ KCA | 87 | L 2-3 | 40-47 | 4 | 21,049 | Felipe Lira | Scott Anderson | Scott Anderson | Felipe Lira | Jeff Montgomery | 440 | 503 | -63 |
| 1995-08-01 | vs BOS | 88 | L 3-13 | 40-48 | 4 | 20,170 | Mike Moore | Zane Smith | Zane Smith | Mike Moore | | 443 | 516 | -73 |
| 1995-08-02 | vs BOS | 89 | W 5-0 | 41-48 | 4 | 16,488 | Sean Bergman | Roger Clemens | Sean Bergman | Roger Clemens | | 448 | 516 | -68 |
| 1995-08-03 | vs BOS | 90 | L 2-10 | 41-49 | 4 | 11,451 | C.J. Nitkowski | Tim Wakefield | Tim Wakefield | C.J. Nitkowski | | 450 | 526 | -76 |
| 1995-08-04 | vs NYA | 91 | L 1-4 | 41-50 | 4 | 23,304 | Jose Lima | Scott Kamieniecki | Scott Kamieniecki | Jose Lima | John Wetteland | 451 | 530 | -79 |
| 1995-08-05 | vs NYA | 92 | L 1-7 | 41-51 | 4 | 21,219 | Felipe Lira | Sterling Hitchcock | Sterling Hitchcock | Felipe Lira | | 452 | 537 | -85 |
| 1995-08-06 | vs NYA | 93 | W 6-5 | 42-51 | 4 | 33,008 | Brian Bohanon | Andy Pettitte | Joe Boever | Dave Eiland | | 458 | 542 | -84 |
| 1995-08-08 | @ TEX | 94 | L 1-4 | 42-52 | 4 | 27,760 | Sean Bergman | Kevin Gross | Kevin Gross | Sean Bergman | Matt Whiteside | 459 | 546 | -87 |
| 1995-08-09 | @ TEX | 95 | L 5-13 | 42-53 | 4 | 22,680 | C.J. Nitkowski | Kenny Rogers | Kenny Rogers | John Doherty | | 464 | 559 | -95 |
| 1995-08-10 | @ TEX | 96 | L 2-7 | 42-54 | 4 | 32,084 | Felipe Lira | Danny Darwin | Danny Darwin | Felipe Lira | | 466 | 566 | -100 |
| 1995-08-11 | @ MIL | 97 | L 4-5 | 42-55 | 4 | 12,791 | Mike Moore | Brian Givens | Brian Givens | Mike Moore | Mike Fetters | 470 | 571 | -101 |
| 1995-08-12 | @ MIL | 98 | W 8-2 | 43-55 | 4 | 21,342 | Jose Lima | Jamie McAndrew | Jose Lima | Jamie McAndrew | John Doherty | 478 | 573 | -95 |
| 1995-08-13 | @ MIL | 99 | L 3-8 | 43-56 | 4 | 22,756 | Sean Bergman | Ricky Bones | Ricky Bones | Sean Bergman | | 481 | 581 | -100 |
| 1995-08-14 | @ MIL | 100 | L 2-3 | 43-57 | 4 | 16,200 | C.J. Nitkowski | Scott Karl | Scott Karl | Brian Maxcy | Mike Fetters | 483 | 584 | -101 |
| 1995-08-15 | vs TOR | 101 | W 11-5 | 44-57 | 4 | 19,173 | Felipe Lira | Pat Hentgen | Brian Bohanon | Pat Hentgen | | 494 | 589 | -95 |
| 1995-08-16 | vs TOR | 102 | L 4-7 | 44-58 | 4 | 17,551 | Mike Moore | Edwin Hurtado | Edwin Hurtado | Brian Maxcy | Tony Castillo | 498 | 596 | -98 |
| 1995-08-17 | vs TOR | 103 | L 0-3 | 44-59 | 5 | 14,629 | Jose Lima | Al Leiter | Al Leiter | Jose Lima | Tony Castillo | 498 | 599 | -101 |
| 1995-08-18 | vs MIN | 104 | W 3-1 | 45-59 | 4 | 18,265 | Sean Bergman | Jose Parra | Sean Bergman | Jose Parra | John Doherty | 501 | 600 | -99 |
| 1995-08-19 | vs MIN | 105 | L 5-9 | 45-60 | 5 | 15,147 | C.J. Nitkowski | Brad Radke | Brad Radke | C.J. Nitkowski | Pat Mahomes | 506 | 609 | -103 |
| 1995-08-20 | vs MIN | 106 | L 7-8 | 45-61 | 5 | 18,868 | Brian Bohanon | Mike Trombley | Pat Mahomes | John Doherty | | 513 | 617 | -104 |
| 1995-08-21 | vs CHA | 107 | L 3-7 | 45-62 | 5 | 16,890 | Mike Moore | Alex Fernandez | Alex Fernandez | Mike Moore | Kirk McCaskill | 516 | 624 | -108 |
| 1995-08-22 | vs CHA | 108 | L 7-15 | 45-63 | 5 | 16,107 | Jose Lima | Dave Righetti | Jose DeLeon | Jose Lima | | 523 | 639 | -116 |
| 1995-08-23 | vs CHA | 109 | W 7-5 | 46-63 | 5 | 15,506 | Sean Bergman | Wilson Alvarez | Felipe Lira | Roberto Hernandez | | 530 | 644 | -114 |
| 1995-08-25 | @ CLE | 110 | L 5-6 | 46-64 | 5 | 41,676 | C.J. Nitkowski | Ken Hill | Julian Tavarez | Felipe Lira | | 535 | 650 | -115 |
| 1995-08-26 | @ CLE | 111 | L 2-6 | 46-65 | 5 | 41,744 | Mike Moore | Charles Nagy | Charles Nagy | Mike Moore | | 537 | 656 | -119 |
| 1995-08-27 | @ CLE | 112 | L 2-9 | 46-66 | 5 | 41,616 | Jose Lima | Orel Hershiser | Orel Hershiser | Jose Lima | | 539 | 665 | -126 |
| 1995-08-29 | @ CHA | 113 | W 7-5 | 47-66 | 5 | 18,890 | Sean Bergman | Brian Keyser | Sean Bergman | Brian Keyser | Felipe Lira | 546 | 670 | -124 |
| 1995-08-30 | @ CHA | 114 | L 7-10 | 47-67 | 5 | 17,074 | C.J. Nitkowski | Jason Bere | Matt Karchner | Brian Maxcy | Roberto Hernandez | 553 | 680 | -127 |
| 1995-08-31 | @ CHA | 115 | L 0-9 | 47-68 | 5 | 15,883 | Mike Moore | Alex Fernandez | Alex Fernandez | Mike Moore | | 553 | 689 | -136 |
| 1995-09-01 | vs CLE | 116 | L 4-14 | 47-69 | 5 | 16,155 | Jose Lima | Charles Nagy | Charles Nagy | Jose Lima | | 557 | 703 | -146 |
| 1995-09-02 | vs CLE | 117 | W 3-2 | 48-69 | 5 | 22,426 | Felipe Lira | Orel Hershiser | Felipe Lira | Orel Hershiser | John Doherty | 560 | 705 | -145 |
| 1995-09-03 | vs CLE | 118 | L 8-9 | 48-70 | 5 | 25,393 | Sean Bergman | Albie Lopez | Jose Mesa | Joe Boever | | 568 | 714 | -146 |
| 1995-09-04 | vs CLE | 119 | W 3-2 | 49-70 | 5 | 24,987 | Clint Sodowsky | Mark Clark | Clint Sodowsky | Mark Clark | Dwayne Henry | 571 | 716 | -145 |
| 1995-09-05 | @ MIN | 120 | W 6-4 | 50-70 | 4 | 8,358 | C.J. Nitkowski | Oscar Munoz | C.J. Nitkowski | Oscar Munoz | Mike Christopher | 577 | 720 | -143 |
| 1995-09-06 | @ MIN | 121 | L 1-9 | 50-71 | 5 | 7,845 | Jose Lima | Frankie Rodriguez | Frankie Rodriguez | Brian Maxcy | | 578 | 729 | -151 |
| 1995-09-08 | @ TOR | 122 | L 5-9 | 50-72 | 5 | 36,490 | Felipe Lira | Jeff Ware | Jeff Ware | Felipe Lira | | 583 | 738 | -155 |
| 1995-09-09 | @ TOR | 123 | W 5-2 | 51-72 | 5 | 43,127 | Sean Bergman | Juan Guzman | Sean Bergman | Juan Guzman | Dwayne Henry | 588 | 740 | -152 |
| 1995-09-10 | @ TOR | 124 | W 5-2 | 52-72 | 4 | 39,255 | Clint Sodowsky | Pat Hentgen | John Doherty | Mike Timlin | Dwayne Henry | 593 | 742 | -149 |
| 1995-09-11 | @ TOR | 125 | W 3-2 | 53-72 | 4 | 32,135 | C.J. Nitkowski | Paul Menhart | Mike Christopher | Jimmy Rogers | Brian Bohanon | 596 | 744 | -148 |
| 1995-09-12 | vs MIL | 126 | W 5-1 | 54-72 | 4 | 8,874 | Jose Lima | Brian Givens | Jose Lima | Brian Givens | John Doherty | 601 | 745 | -144 |
| 1995-09-13 | vs MIL | 127 | W 5-3 | 55-72 | 4 | 8,967 | Felipe Lira | Ricky Bones | Dwayne Henry | Mike Fetters | | 606 | 748 | -142 |
| 1995-09-14 | vs MIL | 128 | L 3-6 | 55-73 | 4 | 7,775 | Sean Bergman | Steve Sparks | Steve Sparks | Sean Bergman | Mike Fetters | 609 | 754 | -145 |
| 1995-09-15 | vs TEX | 129 | W 3-2 | 56-73 | 4 | 12,059 | Clint Sodowsky | Kevin Gross | Clint Sodowsky | Kevin Gross | Dwayne Henry | 612 | 756 | -144 |
| 1995-09-16 | vs TEX | 130 | L 3-7 | 56-74 | 4 | 17,142 | C.J. Nitkowski | Kenny Rogers | Kenny Rogers | C.J. Nitkowski | | 615 | 763 | -148 |
| 1995-09-17 | vs TEX | 131 | L 0-5 | 56-75 | 4 | 12,940 | Jose Lima | Roger Pavlik | Roger Pavlik | Jose Lima | | 615 | 768 | -153 |
| 1995-09-18 | vs BAL | 132 | L 2-6 | 56-76 | 4 | 12,637 | Felipe Lira | Jimmy Haynes | Jimmy Haynes | Felipe Lira | | 617 | 774 | -157 |
| 1995-09-19 | vs BAL | 133 | W 7-4 | 57-76 | 4 | 9,647 | Sean Bergman | Rick Krivda | Mike Myers | Rick Krivda | Dwayne Henry | 624 | 778 | -154 |
| 1995-09-20 | vs BAL | 134 | L 3-6 | 57-77 | 4 | 8,397 | Clint Sodowsky | Scott Erickson | Scott Erickson | Clint Sodowsky | | 627 | 784 | -157 |
| 1995-09-21 | vs BAL | 135 | L 1-13 | 57-78 | 4 | 14,803 | C.J. Nitkowski | Mike Mussina | Mike Mussina | John Doherty | | 628 | 797 | -169 |
| 1995-09-23 | @ NYA | 136 | L 2-5 | 57-80 | 4 | 0 | Jose Lima | David Cone | David Cone | Jose Lima | John Wetteland | 630 | 802 | -172 |
| 1995-09-23 | @ NYA | 137 | L 1-3 | 57-80 | 4 | 36,248 | Felipe Lira | Scott Kamieniecki | Scott Kamieniecki | Felipe Lira | John Wetteland | 631 | 805 | -174 |
| 1995-09-24 | @ NYA | 138 | W 8-3 | 58-80 | 4 | 34,848 | Sean Bergman | Andy Pettitte | Mike Christopher | Andy Pettitte | | 639 | 808 | -169 |
| 1995-09-25 | @ BOS | 139 | W 7-4 | 59-80 | 4 | 25,661 | Clint Sodowsky | Matt Murray | Greg Gohr | Matt Murray | John Doherty | 646 | 812 | -166 |
| 1995-09-26 | @ BOS | 140 | L 1-5 | 59-81 | 4 | 24,032 | C.J. Nitkowski | Zane Smith | Zane Smith | C.J. Nitkowski | | 647 | 817 | -170 |
| 1995-09-27 | @ BOS | 141 | W 7-5 | 60-81 | 4 | 30,989 | Jose Lima | Tim Wakefield | Jose Lima | Tim Wakefield | Ben Blomdahl | 654 | 822 | -168 |
| 1995-09-29 | @ BAL | 142 | L 0-6 | 60-82 | 4 | 46,512 | Felipe Lira | Kevin Brown | Kevin Brown | Felipe Lira | | 654 | 828 | -174 |
| 1995-09-30 | @ BAL | 143 | L 0-12 | 60-83 | 4 | 47,132 | Sean Bergman | Ben McDonald | Ben McDonald | Sean Bergman | | 654 | 840 | -186 |
| 1995-10-01 | @ BAL | 144 | L 0-4 | 60-84 | 4 | 45,760 | Clint Sodowsky | Mike Mussina | Mike Mussina | Clint Sodowsky | | 654 | 844 | -190 |