| 1993-04-05 | vs NYA | 1 | L 1-9 | 0-1 | 4 | 73,290 | Charles Nagy | Jimmy Key | Jimmy Key | Charles Nagy | | 1 | 9 | -8 |
| 1993-04-07 | vs NYA | 2 | W 4-2 | 1-1 | 2 | 12,512 | Jeff Mutis | Jim Abbott | Eric Plunk | Jim Abbott | Derek Lilliquist | 5 | 11 | -6 |
| 1993-04-08 | vs NYA | 3 | W 15-5 | 2-1 | 2 | 13,834 | Mike Bielecki | Sam Militello | Mike Bielecki | Sam Militello | | 20 | 16 | 4 |
| 1993-04-09 | @ TOR | 4 | L 10-13 | 2-2 | 4 | 50,533 | Jose Mesa | Juan Guzman | Mark Eichhorn | Ted Power | Duane Ward | 30 | 29 | 1 |
| 1993-04-10 | @ TOR | 5 | L 4-5 | 2-3 | 5 | 50,492 | Charles Nagy | Todd Stottlemyre | Todd Stottlemyre | Charles Nagy | Duane Ward | 34 | 34 | 0 |
| 1993-04-11 | @ TOR | 6 | W 10-6 | 3-3 | 3 | 47,194 | Mark Clark | Jack Morris | Mark Clark | Jack Morris | Derek Lilliquist | 44 | 40 | 4 |
| 1993-04-13 | @ BOS | 7 | L 2-6 | 3-4 | 4 | 29,606 | Jeff Mutis | Frank Viola | Frank Viola | Jeff Mutis | | 46 | 46 | 0 |
| 1993-04-14 | @ BOS | 8 | L 7-12 | 3-5 | 5 | 20,390 | Mike Bielecki | John Dopson | Joe Hesketh | Mike Bielecki | | 53 | 58 | -5 |
| 1993-04-15 | @ BOS | 9 | L 3-4 | 3-6 | 5 | 22,505 | Jose Mesa | Roger Clemens | Paul Quantrill | Eric Plunk | | 56 | 62 | -6 |
| 1993-04-16 | vs TOR | 10 | W 13-1 | 4-6 | 5 | 17,428 | Charles Nagy | Jack Morris | Charles Nagy | Jack Morris | | 69 | 63 | 6 |
| 1993-04-17 | vs TOR | 11 | L 1-8 | 4-7 | 6 | 21,755 | Mark Clark | Pat Hentgen | Pat Hentgen | Mark Clark | | 70 | 71 | -1 |
| 1993-04-18 | vs TOR | 12 | W 6-5 | 5-7 | 6 | 24,368 | Jeff Mutis | Al Leiter | Jeff Mutis | Al Leiter | Derek Lilliquist | 76 | 76 | 0 |
| 1993-04-19 | vs TOR | 13 | L 1-7 | 5-8 | 6 | 11,750 | Mike Bielecki | Juan Guzman | Juan Guzman | Mike Bielecki | | 77 | 83 | -6 |
| 1993-04-20 | @ CAL | 14 | L 2-7 | 5-9 | 6 | 17,271 | Jose Mesa | Scott Sanderson | Scott Sanderson | Jose Mesa | | 79 | 90 | -11 |
| 1993-04-21 | @ CAL | 15 | L 6-7 | 5-10 | 7 | 17,274 | Charles Nagy | John Farrell | John Farrell | Charles Nagy | Steve Frey | 85 | 97 | -12 |
| 1993-04-22 | @ CAL | 16 | L 0-8 | 5-11 | 6 | 17,437 | Mark Clark | Chuck Finley | Chuck Finley | Mark Clark | | 85 | 105 | -20 |
| 1993-04-24 | @ OAK | 17 | W 10-3 | 6-11 | 6 | 26,781 | Mike Bielecki | Shawn Hillegas | Mike Bielecki | Shawn Hillegas | | 95 | 108 | -13 |
| 1993-04-25 | @ OAK | 18 | W 6-0 | 7-11 | 6 | 28,084 | Jose Mesa | Storm Davis | Jose Mesa | Storm Davis | | 101 | 108 | -7 |
| 1993-04-26 | @ SEA | 19 | L 3-6 | 7-12 | 6 | 22,230 | Matt Young | Randy Johnson | Randy Johnson | Tom Kramer | | 104 | 114 | -10 |
| 1993-04-27 | @ SEA | 20 | L 0-4 | 7-13 | 6 | 13,178 | Charles Nagy | Chris Bosio | Chris Bosio | Charles Nagy | | 104 | 118 | -14 |
| 1993-04-28 | @ SEA | 21 | L 0-4 | 7-14 | 6 | 12,351 | Jeff Mutis | Erik Hanson | Erik Hanson | Jeff Mutis | Norm Charlton | 104 | 122 | -18 |
| 1993-04-30 | vs OAK | 22 | L 2-8 | 7-15 | 7 | 30,634 | Mike Bielecki | Ron Darling | Rich Gossage | Eric Plunk | | 106 | 130 | -24 |
| 1993-05-01 | vs OAK | 23 | W 1-0 | 8-15 | 7 | 19,589 | Jose Mesa | Storm Davis | Jose Mesa | Storm Davis | Eric Plunk | 107 | 130 | -23 |
| 1993-05-02 | vs OAK | 24 | W 10-2 | 9-15 | 7 | 22,458 | Charles Nagy | Bobby Witt | Charles Nagy | Bobby Witt | | 117 | 132 | -15 |
| 1993-05-03 | vs CAL | 25 | W 5-4 | 10-15 | 6 | 10,057 | Matt Young | Mark Langston | Derek Lilliquist | Julio Valera | | 122 | 136 | -14 |
| 1993-05-04 | vs CAL | 26 | W 5-3 | 11-15 | 6 | 11,405 | Tom Kramer | Scott Lewis | Dennis Cook | Scott Lewis | Derek Lilliquist | 127 | 139 | -12 |
| 1993-05-05 | vs SEA | 27 | W 3-2 | 12-15 | 5 | 11,250 | Mike Bielecki | John Cummings | Mike Bielecki | John Cummings | Derek Lilliquist | 130 | 141 | -11 |
| 1993-05-06 | vs SEA | 28 | L 5-9 | 12-16 | 6 | 13,279 | Jose Mesa | Randy Johnson | Randy Johnson | Jose Mesa | | 135 | 150 | -15 |
| 1993-05-07 | @ CHA | 29 | L 5-6 | 12-17 | 6 | 24,873 | Charles Nagy | Wilson Alvarez | Wilson Alvarez | Charles Nagy | Roberto Hernandez | 140 | 156 | -16 |
| 1993-05-08 | @ CHA | 30 | L 7-10 | 12-18 | 6 | 33,933 | Matt Young | Jack McDowell | Jack McDowell | Cliff Young | Roberto Hernandez | 147 | 166 | -19 |
| 1993-05-09 | @ CHA | 31 | L 5-6 | 12-19 | 7 | 23,126 | Mark Clark | Kirk McCaskill | Scott Radinsky | Derek Lilliquist | | 152 | 172 | -20 |
| 1993-05-11 | vs KCA | 32 | L 6-7 | 12-20 | 7 | 12,800 | Mike Bielecki | Kevin Appier | Kevin Appier | Dennis Cook | Jeff Montgomery | 158 | 179 | -21 |
| 1993-05-12 | vs KCA | 33 | W 6-2 | 13-20 | 7 | 12,081 | Jose Mesa | Mark Gardner | Jose Mesa | Mark Gardner | | 164 | 181 | -17 |
| 1993-05-13 | vs KCA | 34 | L 3-7 | 13-21 | 7 | 12,781 | Matt Young | Hipolito Pichardo | Hipolito Pichardo | Matt Young | | 167 | 188 | -21 |
| 1993-05-14 | @ MIL | 35 | L 2-5 | 13-22 | 7 | 14,633 | Cliff Young | Mike Boddicker | Mike Boddicker | Cliff Young | Doug Henry | 169 | 193 | -24 |
| 1993-05-15 | @ MIL | 36 | W 9-5 | 14-22 | 6 | 31,171 | Charles Nagy | Ricky Bones | Dennis Cook | Ricky Bones | | 178 | 198 | -20 |
| 1993-05-16 | @ MIL | 37 | L 3-5 | 14-23 | 7 | 20,028 | Mike Bielecki | Jaime Navarro | Jaime Navarro | Mike Bielecki | Doug Henry | 181 | 203 | -22 |
| 1993-05-17 | @ BAL | 38 | W 2-0 | 15-23 | 6 | 42,756 | Jose Mesa | Ben McDonald | Jose Mesa | Ben McDonald | Eric Plunk | 183 | 203 | -20 |
| 1993-05-18 | @ BAL | 39 | L 0-7 | 15-24 | 7 | 43,710 | Matt Young | Fernando Valenzuela | Fernando Valenzuela | Matt Young | | 183 | 210 | -27 |
| 1993-05-19 | @ BAL | 40 | L 3-6 | 15-25 | 7 | 40,307 | Scott Scudder | Rick Sutcliffe | Rick Sutcliffe | Scott Scudder | Gregg Olson | 186 | 216 | -30 |
| 1993-05-20 | @ BAL | 41 | W 3-1 | 16-25 | 7 | 45,706 | Dennis Cook | Jamie Moyer | Dennis Cook | Jamie Moyer | Derek Lilliquist | 189 | 217 | -28 |
| 1993-05-21 | vs DET | 42 | W 10-5 | 17-25 | 6 | 45,765 | Mike Bielecki | Bill Gullickson | Mike Bielecki | Bill Gullickson | Cliff Young | 199 | 222 | -23 |
| 1993-05-22 | vs DET | 43 | L 1-5 | 17-26 | 7 | 27,611 | Jose Mesa | Mike Moore | Mike Moore | Jose Mesa | | 200 | 227 | -27 |
| 1993-05-23 | vs DET | 44 | L 2-4 | 17-27 | 7 | 22,920 | Matt Young | Mark Leiter | Mark Leiter | Matt Young | Mike Henneman | 202 | 231 | -29 |
| 1993-05-24 | vs TEX | 45 | W 4-1 | 18-27 | 7 | 10,721 | Tom Kramer | Kevin Brown | Tom Kramer | Kevin Brown | | 206 | 232 | -26 |
| 1993-05-25 | vs TEX | 46 | L 1-5 | 18-28 | 7 | 12,559 | Dennis Cook | Charlie Leibrandt | Charlie Leibrandt | Dennis Cook | | 207 | 237 | -30 |
| 1993-05-26 | vs TEX | 47 | W 7-6 | 19-28 | 7 | 14,305 | Jose Mesa | Kenny Rogers | Jose Mesa | Kenny Rogers | Eric Plunk | 214 | 243 | -29 |
| 1993-05-28 | @ MIN | 48 | L 6-7 | 19-29 | 7 | 19,450 | Matt Young | Scott Erickson | Rick Aguilera | Ted Power | | 220 | 250 | -30 |
| 1993-05-29 | @ MIN | 49 | L 3-9 | 19-30 | 7 | 24,553 | Mike Bielecki | Willie Banks | Willie Banks | Mike Bielecki | | 223 | 259 | -36 |
| 1993-05-30 | @ MIN | 50 | L 2-8 | 19-31 | 7 | 27,607 | Tom Kramer | Jim Deshaies | Jim Deshaies | Tom Kramer | Mike Trombley | 225 | 267 | -42 |
| 1993-05-31 | @ NYA | 51 | L 2-8 | 19-32 | 7 | 20,062 | Dennis Cook | Melido Perez | Melido Perez | Dennis Cook | | 227 | 275 | -48 |
| 1993-06-01 | @ NYA | 52 | W 15-6 | 20-32 | 7 | 14,661 | Jose Mesa | Mike Witt | Cliff Young | Mike Witt | | 242 | 281 | -39 |
| 1993-06-02 | @ NYA | 53 | L 5-8 | 20-33 | 7 | 14,374 | Matt Young | Jimmy Key | Jimmy Key | Matt Young | Steve Farr | 247 | 289 | -42 |
| 1993-06-04 | vs MIN | 54 | L 2-3 | 20-34 | 7 | 24,081 | Mike Bielecki | Jim Deshaies | Jim Deshaies | Jeremy Hernandez | Rick Aguilera | 249 | 292 | -43 |
| 1993-06-05 | vs MIN | 55 | W 7-6 | 21-34 | 7 | 25,077 | Tom Kramer | Kevin Tapani | Eric Plunk | Mike Trombley | | 256 | 298 | -42 |
| 1993-06-06 | vs MIN | 56 | L 4-5 | 21-35 | 7 | 24,187 | Dennis Cook | Scott Erickson | Scott Erickson | Dennis Cook | Rick Aguilera | 260 | 303 | -43 |
| 1993-06-08 | vs BOS | 57 | W 5-4 | 22-35 | 7 | 14,168 | Jose Mesa | Roger Clemens | Derek Lilliquist | Greg Harris | | 265 | 307 | -42 |
| 1993-06-09 | vs BOS | 58 | W 3-2 | 23-35 | 7 | 13,381 | Mike Bielecki | Danny Darwin | Cliff Young | Danny Darwin | Eric Plunk | 268 | 309 | -41 |
| 1993-06-11 | @ TEX | 59 | W 8-3 | 24-35 | 7 | 27,560 | Tom Kramer | Kevin Brown | Heathcliff Slocumb | Kevin Brown | | 276 | 312 | -36 |
| 1993-06-12 | @ TEX | 60 | W 10-9 | 25-35 | 7 | 30,111 | Dennis Cook | Kenny Rogers | Matt Young | Kenny Rogers | Derek Lilliquist | 286 | 321 | -35 |
| 1993-06-13 | @ TEX | 61 | L 1-5 | 25-36 | 7 | 20,829 | Jose Mesa | Roger Pavlik | Roger Pavlik | Jose Mesa | | 287 | 326 | -39 |
| 1993-06-14 | @ DET | 62 | L 3-7 | 25-37 | 7 | 21,281 | Mike Bielecki | David Wells | David Wells | Mike Bielecki | | 290 | 333 | -43 |
| 1993-06-15 | @ DET | 63 | L 4-10 | 25-38 | 7 | 18,183 | Paul Abbott | Buddy Groom | Bill Krueger | Paul Abbott | | 294 | 343 | -49 |
| 1993-06-16 | @ DET | 64 | W 8-2 | 26-38 | 7 | 17,956 | Tom Kramer | Bill Gullickson | Tom Kramer | Bill Gullickson | Jeremy Hernandez | 302 | 345 | -43 |
| 1993-06-17 | @ DET | 65 | L 5-9 | 26-39 | 7 | 31,145 | Dennis Cook | Mike Moore | Mike Moore | Heathcliff Slocumb | | 307 | 354 | -47 |
| 1993-06-18 | vs BAL | 66 | L 1-4 | 26-40 | 7 | 35,594 | Jose Mesa | Ben McDonald | Ben McDonald | Jose Mesa | Gregg Olson | 308 | 358 | -50 |
| 1993-06-19 | vs BAL | 67 | W 3-0 | 27-40 | 7 | 38,619 | Mark Clark | Fernando Valenzuela | Mark Clark | Fernando Valenzuela | Eric Plunk | 311 | 358 | -47 |
| 1993-06-20 | vs BAL | 68 | L 3-6 | 27-41 | 7 | 37,605 | Paul Abbott | Jamie Moyer | Jamie Moyer | Matt Young | Gregg Olson | 314 | 364 | -50 |
| 1993-06-21 | vs MIL | 69 | W 3-0 | 28-41 | 7 | 11,336 | Tom Kramer | Jaime Navarro | Tom Kramer | Jaime Navarro | Jeremy Hernandez | 317 | 364 | -47 |
| 1993-06-22 | vs MIL | 70 | W 3-2 | 29-41 | 7 | 16,987 | Cliff Young | Cal Eldred | Heathcliff Slocumb | Cal Eldred | Derek Lilliquist | 320 | 366 | -46 |
| 1993-06-23 | vs MIL | 71 | W 3-1 | 30-41 | 6 | 12,662 | Jose Mesa | Bill Wegman | Jose Mesa | Bill Wegman | Jeremy Hernandez | 323 | 367 | -44 |
| 1993-06-24 | vs MIL | 72 | L 3-5 | 30-42 | 7 | 13,225 | Mark Clark | Ricky Bones | Ricky Bones | Mark Clark | Doug Henry | 326 | 372 | -46 |
| 1993-06-25 | vs KCA | 73 | W 6-1 | 31-42 | 7 | 17,207 | Paul Abbott | Mark Gardner | Dennis Cook | Mark Gubicza | | 332 | 373 | -41 |
| 1993-06-26 | vs KCA | 74 | W 7-4 | 32-42 | 6 | 25,475 | Tom Kramer | Hipolito Pichardo | Jeremy Hernandez | Frank DiPino | Eric Plunk | 339 | 377 | -38 |
| 1993-06-27 | vs KCA | 75 | W 3-2 | 33-42 | 6 | 36,210 | Cliff Young | David Cone | Eric Plunk | David Cone | | 342 | 379 | -37 |
| 1993-06-28 | vs CHA | 76 | W 2-0 | 34-42 | 6 | 14,662 | Jose Mesa | Jason Bere | Jose Mesa | Jason Bere | Eric Plunk | 344 | 379 | -35 |
| 1993-06-29 | vs CHA | 77 | W 8-2 | 35-42 | 6 | 24,744 | Mark Clark | Rod Bolton | Mark Clark | Rod Bolton | | 352 | 381 | -29 |
| 1993-06-30 | vs CHA | 78 | W 4-2 | 36-42 | 6 | 18,801 | Paul Abbott | Wilson Alvarez | Dennis Cook | Wilson Alvarez | Jeremy Hernandez | 356 | 383 | -27 |
| 1993-07-02 | @ CAL | 79 | W 10-8 | 37-42 | 6 | 26,011 | Tom Kramer | Scott Sanderson | Heathcliff Slocumb | Gene Nelson | Eric Plunk | 366 | 391 | -25 |
| 1993-07-03 | @ CAL | 80 | W 5-3 | 38-42 | 6 | 20,688 | Jose Mesa | Hilly Hathaway | Jose Mesa | Hilly Hathaway | Eric Plunk | 371 | 394 | -23 |
| 1993-07-04 | @ CAL | 81 | L 6-7 | 38-43 | 6 | 52,329 | Cliff Young | Mark Langston | Mike Butcher | Matt Young | | 377 | 401 | -24 |
| 1993-07-05 | @ OAK | 82 | L 5-6 | 39-44 | 6 | 0 | Paul Abbott | Kelly Downs | Vince Horsman | Dennis Cook | Dennis Eckersley | 382 | 407 | -25 |
| 1993-07-05 | @ OAK | 83 | W 6-2 | 39-44 | 6 | 27,376 | Mark Clark | Curt Young | Mark Clark | Curt Young | Jeremy Hernandez | 388 | 409 | -21 |
| 1993-07-06 | @ OAK | 84 | W 11-8 | 40-44 | 6 | 19,599 | Albie Lopez | Bob Welch | Eric Plunk | Rich Gossage | Jeremy Hernandez | 399 | 417 | -18 |
| 1993-07-07 | @ OAK | 85 | L 0-3 | 40-45 | 6 | 20,830 | Jose Mesa | Mike Mohler | Joe Boever | Jose Mesa | Dennis Eckersley | 399 | 420 | -21 |
| 1993-07-09 | @ SEA | 86 | L 4-6 | 40-46 | 6 | 19,567 | Cliff Young | Dave Fleming | Dave Fleming | Cliff Young | Chris Bosio | 403 | 426 | -23 |
| 1993-07-10 | @ SEA | 87 | L 6-7 | 40-47 | 6 | 28,003 | Mark Clark | Randy Johnson | Chris Bosio | Jeremy Hernandez | | 409 | 433 | -24 |
| 1993-07-11 | @ SEA | 88 | L 4-5 | 40-48 | 6 | 24,572 | Jeff Mutis | Erik Hanson | Bob Ayrault | Eric Plunk | | 413 | 438 | -25 |
| 1993-07-15 | vs CAL | 89 | W 7-3 | 41-48 | 6 | 21,085 | Jose Mesa | Scott Sanderson | Jerry DiPoto | Scott Sanderson | | 420 | 441 | -21 |
| 1993-07-16 | vs CAL | 90 | L 1-2 | 41-49 | 6 | 23,634 | Mark Clark | Chuck Finley | Chuck Finley | Mark Clark | Mike Butcher | 421 | 443 | -22 |
| 1993-07-17 | vs CAL | 91 | W 3-0 | 42-49 | 6 | 33,402 | Jeff Mutis | Russ Springer | Jeff Mutis | Russ Springer | | 424 | 443 | -19 |
| 1993-07-18 | vs CAL | 92 | W 2-1 | 43-49 | 6 | 31,330 | Albie Lopez | Mark Langston | Albie Lopez | Mark Langston | Jerry DiPoto | 426 | 444 | -18 |
| 1993-07-19 | vs OAK | 93 | W 4-2 | 44-49 | 6 | 18,072 | Cliff Young | Todd Van Poppel | Cliff Young | Todd Van Poppel | Jeremy Hernandez | 430 | 446 | -16 |
| 1993-07-20 | vs OAK | 94 | W 9-5 | 45-49 | 6 | 28,347 | Jose Mesa | Mike Mohler | Jose Mesa | Mike Mohler | | 439 | 451 | -12 |
| 1993-07-21 | vs OAK | 95 | L 2-7 | 45-50 | 6 | 27,014 | Tom Kramer | Kelly Downs | Bob Welch | Bill Wertz | | 441 | 458 | -17 |
| 1993-07-22 | vs SEA | 96 | L 2-3 | 45-51 | 6 | 20,203 | Jeff Mutis | Chris Bosio | Chris Bosio | Jeff Mutis | Brad Holman | 443 | 461 | -18 |
| 1993-07-23 | vs SEA | 97 | W 9-4 | 46-51 | 6 | 48,454 | Albie Lopez | Randy Johnson | Albie Lopez | Randy Johnson | | 452 | 465 | -13 |
| 1993-07-24 | vs SEA | 98 | L 5-6 | 46-52 | 6 | 33,750 | Cliff Young | Tim Leary | Jeff Nelson | Jerry DiPoto | Brad Holman | 457 | 471 | -14 |
| 1993-07-25 | vs SEA | 99 | W 11-9 | 47-52 | 6 | 54,378 | Jose Mesa | Dave Fleming | Jeremy Hernandez | Jeff Nelson | Derek Lilliquist | 468 | 480 | -12 |
| 1993-07-26 | @ CHA | 100 | L 3-4 | 47-53 | 6 | 32,431 | Tom Kramer | Wilson Alvarez | Jeff Schwarz | Jerry DiPoto | Roberto Hernandez | 471 | 484 | -13 |
| 1993-07-27 | @ CHA | 101 | L 4-7 | 47-54 | 6 | 29,358 | Jeff Mutis | Jack McDowell | Jack McDowell | Jeff Mutis | Roberto Hernandez | 475 | 491 | -16 |
| 1993-07-28 | @ CHA | 102 | L 4-9 | 47-55 | 6 | 30,786 | Albie Lopez | Jason Bere | Jason Bere | Albie Lopez | | 479 | 500 | -21 |
| 1993-07-30 | @ KCA | 103 | L 0-3 | 47-56 | 6 | 31,769 | Jose Mesa | David Cone | David Cone | Jose Mesa | | 479 | 503 | -24 |
| 1993-07-31 | @ KCA | 104 | W 6-4 | 48-56 | 6 | 31,712 | Tom Kramer | Chris Haney | Tom Kramer | Chris Haney | Eric Plunk | 485 | 507 | -22 |
| 1993-08-01 | @ KCA | 105 | W 9-5 | 49-56 | 6 | 22,818 | Jeff Mutis | Kevin Appier | Bill Wertz | Kevin Appier | Eric Plunk | 494 | 512 | -18 |
| 1993-08-03 | vs DET | 106 | W 9-4 | 50-56 | 6 | 28,128 | Albie Lopez | Sean Bergman | Albie Lopez | Sean Bergman | Jerry DiPoto | 503 | 516 | -13 |
| 1993-08-04 | vs DET | 107 | L 3-8 | 50-57 | 6 | 23,751 | Jose Mesa | Mike Moore | Mike Moore | Jose Mesa | | 506 | 524 | -18 |
| 1993-08-05 | vs DET | 108 | W 8-4 | 51-57 | 6 | 34,554 | Tom Kramer | John Doherty | Tom Kramer | John Doherty | | 514 | 528 | -14 |
| 1993-08-06 | @ BAL | 109 | L 1-8 | 51-58 | 6 | 46,219 | Jeff Mutis | Rick Sutcliffe | Rick Sutcliffe | Jeff Mutis | | 515 | 536 | -21 |
| 1993-08-07 | @ BAL | 110 | L 6-8 | 51-59 | 6 | 46,424 | Julian Tavarez | Fernando Valenzuela | Alan Mills | Julian Tavarez | Gregg Olson | 521 | 544 | -23 |
| 1993-08-08 | @ BAL | 111 | L 6-7 | 51-60 | 6 | 46,336 | Albie Lopez | Jamie Moyer | Todd Frohwirth | Eric Plunk | | 527 | 551 | -24 |
| 1993-08-10 | @ MIL | 112 | L 4-5 | 51-61 | 6 | 20,497 | Jose Mesa | Cal Eldred | Doug Henry | Eric Plunk | | 531 | 556 | -25 |
| 1993-08-11 | @ MIL | 113 | W 7-5 | 52-61 | 6 | 18,173 | Tom Kramer | Rafael Novoa | Jerry DiPoto | Jesse Orosco | Derek Lilliquist | 538 | 561 | -23 |
| 1993-08-12 | @ MIL | 114 | W 8-6 | 53-61 | 6 | 20,521 | Jeff Mutis | Jaime Navarro | Jerry DiPoto | Carlos Maldonado | Eric Plunk | 546 | 567 | -21 |
| 1993-08-13 | vs TEX | 115 | W 6-3 | 54-61 | 6 | 27,159 | Albie Lopez | Roger Pavlik | Jeremy Hernandez | Craig Lefferts | | 552 | 570 | -18 |
| 1993-08-14 | vs TEX | 116 | W 8-5 | 55-61 | 6 | 36,360 | Julian Tavarez | Steve Dreyer | Julian Tavarez | Steve Dreyer | Eric Plunk | 560 | 575 | -15 |
| 1993-08-15 | vs TEX | 117 | L 1-4 | 55-62 | 6 | 60,727 | Jose Mesa | Nolan Ryan | Nolan Ryan | Jose Mesa | Tom Henke | 561 | 579 | -18 |
| 1993-08-16 | vs TOR | 118 | L 1-4 | 55-63 | 6 | 25,546 | Bob Ojeda | Juan Guzman | Juan Guzman | Bob Ojeda | Duane Ward | 562 | 583 | -21 |
| 1993-08-17 | vs TOR | 119 | L 4-6 | 55-64 | 6 | 40,253 | Tom Kramer | Jack Morris | Jack Morris | Tom Kramer | Duane Ward | 566 | 589 | -23 |
| 1993-08-18 | vs TOR | 120 | L 6-7 | 55-65 | 6 | 24,003 | Albie Lopez | Todd Stottlemyre | Danny Cox | Derek Lilliquist | Duane Ward | 572 | 596 | -24 |
| 1993-08-19 | @ BOS | 121 | W 5-1 | 56-65 | 6 | 32,644 | Julian Tavarez | Paul Quantrill | Julian Tavarez | Paul Quantrill | | 577 | 597 | -20 |
| 1993-08-20 | @ BOS | 122 | W 7-6 | 57-65 | 6 | 31,819 | Jose Mesa | Frank Viola | Jerry DiPoto | Jeff Russell | | 584 | 603 | -19 |
| 1993-08-21 | @ BOS | 123 | W 10-5 | 58-65 | 6 | 32,888 | Bob Ojeda | Roger Clemens | Bill Wertz | Greg Harris | | 594 | 608 | -14 |
| 1993-08-22 | @ BOS | 124 | W 3-2 | 59-65 | 6 | 33,560 | Derek Lilliquist | Aaron Sele | Tom Kramer | Ken Ryan | Jerry DiPoto | 597 | 610 | -13 |
| 1993-08-23 | @ TOR | 125 | W 9-8 | 60-65 | 6 | 50,518 | Albie Lopez | Jack Morris | Jeremy Hernandez | Mark Eichhorn | Jerry DiPoto | 606 | 618 | -12 |
| 1993-08-24 | @ TOR | 126 | L 6-8 | 60-66 | 6 | 50,511 | Julian Tavarez | Todd Stottlemyre | Todd Stottlemyre | Julian Tavarez | Duane Ward | 612 | 626 | -14 |
| 1993-08-25 | @ TOR | 127 | L 7-10 | 60-67 | 6 | 50,525 | Jose Mesa | Pat Hentgen | Pat Hentgen | Jose Mesa | Duane Ward | 619 | 636 | -17 |
| 1993-08-26 | vs NYA | 128 | L 0-4 | 60-68 | 6 | 28,425 | Bob Ojeda | Sterling Hitchcock | Sterling Hitchcock | Bill Wertz | Bob Wickman | 619 | 640 | -21 |
| 1993-08-27 | vs NYA | 129 | W 9-2 | 61-68 | 6 | 57,152 | Derek Lilliquist | Melido Perez | Jason Grimsley | Melido Perez | | 628 | 642 | -14 |
| 1993-08-28 | vs NYA | 130 | W 8-4 | 62-68 | 6 | 36,436 | Jeff Mutis | Jimmy Key | Jeff Mutis | Jimmy Key | Jeremy Hernandez | 636 | 646 | -10 |
| 1993-08-29 | vs NYA | 131 | L 8-14 | 62-69 | 6 | 56,825 | Tom Kramer | Jim Abbott | Rich Monteleone | Jason Grimsley | | 644 | 660 | -16 |
| 1993-08-31 | @ MIN | 132 | L 4-5 | 62-70 | 6 | 17,968 | Jose Mesa | Willie Banks | Brett Merriman | Jason Grimsley | | 648 | 665 | -17 |
| 1993-09-01 | @ MIN | 133 | W 12-7 | 63-70 | 6 | 19,085 | Julian Tavarez | Mike Trombley | Derek Lilliquist | Mike Trombley | Eric Plunk | 660 | 672 | -12 |
| 1993-09-02 | @ MIN | 134 | W 4-3 | 64-70 | 6 | 14,189 | Jason Grimsley | Kevin Tapani | Tom Kramer | Kevin Tapani | Jerry DiPoto | 664 | 675 | -11 |
| 1993-09-03 | @ NYA | 135 | W 7-3 | 65-70 | 6 | 29,041 | Bob Ojeda | Melido Perez | Bob Ojeda | Melido Perez | Jerry DiPoto | 671 | 678 | -7 |
| 1993-09-04 | @ NYA | 136 | L 0-4 | 65-71 | 6 | 27,125 | Bob Milacki | Jim Abbott | Jim Abbott | Bob Milacki | | 671 | 682 | -11 |
| 1993-09-05 | @ NYA | 137 | L 2-7 | 65-72 | 6 | 29,995 | Jeff Mutis | Sterling Hitchcock | Bob Wickman | Jeff Mutis | | 673 | 689 | -16 |
| 1993-09-07 | vs MIN | 138 | L 0-6 | 65-73 | 6 | 13,276 | Jason Grimsley | Kevin Tapani | Kevin Tapani | Jason Grimsley | | 673 | 695 | -22 |
| 1993-09-08 | vs MIN | 139 | W 15-8 | 66-73 | 6 | 13,590 | Jose Mesa | Greg Brummett | Jose Mesa | Greg Brummett | | 688 | 703 | -15 |
| 1993-09-09 | vs MIN | 140 | L 3-5 | 66-74 | 6 | 10,408 | Mark Clark | Scott Erickson | Rick Aguilera | Derek Lilliquist | | 691 | 708 | -17 |
| 1993-09-10 | vs BOS | 141 | W 7-4 | 67-75 | 6 | 0 | Bob Ojeda | Roger Clemens | Bob Ojeda | Roger Clemens | Jerry DiPoto | 698 | 712 | -14 |
| 1993-09-10 | vs BOS | 142 | L 4-5 | 67-75 | 6 | 36,261 | Bob Milacki | Frank Viola | Ken Ryan | Bill Wertz | | 702 | 717 | -15 |
| 1993-09-11 | vs BOS | 143 | W 9-3 | 68-75 | 6 | 28,788 | Julian Tavarez | Aaron Sele | Derek Lilliquist | Paul Quantrill | | 711 | 720 | -9 |
| 1993-09-12 | vs BOS | 144 | L 1-11 | 68-76 | 6 | 30,170 | Jason Grimsley | Nate Minchey | Nate Minchey | Jason Grimsley | | 712 | 731 | -19 |
| 1993-09-13 | @ TEX | 145 | L 1-12 | 68-77 | 6 | 18,904 | Jose Mesa | Kevin Brown | Kevin Brown | Jose Mesa | | 713 | 743 | -30 |
| 1993-09-14 | @ TEX | 146 | W 2-0 | 69-77 | 6 | 17,564 | Mark Clark | Kenny Rogers | Mark Clark | Kenny Rogers | Jerry DiPoto | 715 | 743 | -28 |
| 1993-09-15 | @ TEX | 147 | L 4-7 | 69-78 | 6 | 22,837 | Bob Ojeda | Roger Pavlik | Cris Carpenter | Jeremy Hernandez | Tom Henke | 719 | 750 | -31 |
| 1993-09-17 | @ DET | 148 | W 3-1 | 70-78 | 6 | 17,985 | Jason Grimsley | David Wells | Jason Grimsley | David Wells | Jerry DiPoto | 722 | 751 | -29 |
| 1993-09-18 | @ DET | 149 | L 6-7 | 70-79 | 6 | 27,384 | Jose Mesa | John Doherty | Tom Bolton | Jose Mesa | Storm Davis | 728 | 758 | -30 |
| 1993-09-19 | @ DET | 150 | W 12-2 | 71-79 | 6 | 22,822 | Mark Clark | Bill Gullickson | Mark Clark | Bill Gullickson | | 740 | 760 | -20 |
| 1993-09-20 | vs BAL | 151 | W 6-4 | 72-79 | 6 | 11,751 | Dave Mlicki | Fernando Valenzuela | Bob Milacki | Fernando Valenzuela | Jerry DiPoto | 746 | 764 | -18 |
| 1993-09-21 | vs BAL | 152 | L 6-7 | 72-80 | 6 | 19,642 | Bob Ojeda | Rick Sutcliffe | Alan Mills | Jerry DiPoto | | 752 | 771 | -19 |
| 1993-09-22 | vs BAL | 153 | W 4-2 | 73-80 | 6 | 17,113 | Jason Grimsley | Ben McDonald | Jeremy Hernandez | Ben McDonald | Jerry DiPoto | 756 | 773 | -17 |
| 1993-09-24 | vs MIL | 154 | L 8-11 | 73-81 | 6 | 33,533 | Jose Mesa | Angel Miranda | Jesse Orosco | Derek Lilliquist | | 764 | 784 | -20 |
| 1993-09-25 | vs MIL | 155 | W 6-2 | 74-81 | 6 | 26,477 | Mark Clark | Jaime Navarro | Mark Clark | Jaime Navarro | | 770 | 786 | -16 |
| 1993-09-26 | vs MIL | 156 | W 6-4 | 75-81 | 6 | 31,834 | Dave Mlicki | Ricky Bones | Jeremy Hernandez | Mike Ignasiak | | 776 | 790 | -14 |
| 1993-09-27 | @ KCA | 157 | L 5-6 | 75-82 | 6 | 18,244 | Julian Tavarez | Tom Gordon | Mark Gubicza | Jerry DiPoto | | 781 | 796 | -15 |
| 1993-09-28 | @ KCA | 158 | W 3-2 | 76-82 | 6 | 19,468 | Jason Grimsley | Kevin Appier | Jason Grimsley | Kevin Appier | Eric Plunk | 784 | 798 | -14 |
| 1993-09-29 | @ KCA | 159 | L 2-3 | 76-83 | 6 | 36,999 | Jose Mesa | Hipolito Pichardo | Jeff Montgomery | Jeremy Hernandez | | 786 | 801 | -15 |
| 1993-10-01 | vs CHA | 160 | L 2-4 | 76-84 | 6 | 72,454 | Mark Clark | Alex Fernandez | Alex Fernandez | Mark Clark | Roberto Hernandez | 788 | 805 | -17 |
| 1993-10-02 | vs CHA | 161 | L 2-4 | 76-85 | 6 | 72,060 | Dave Mlicki | Wilson Alvarez | Chris Howard | Jeremy Hernandez | Brian Drahman | 790 | 809 | -19 |
| 1993-10-03 | vs CHA | 162 | L 0-4 | 76-86 | 6 | 72,390 | Charles Nagy | Jason Bere | Jason Bere | Charles Nagy | | 790 | 813 | -23 |