| 1992-04-06 | vs TEX | 1 | L 10-12 | 0-1 | 6 | 55,918 | Randy Johnson | Nolan Ryan | Steve Fireovid | Mike Schooler | Jeff Russell | 10 | 12 | -2 |
| 1992-04-07 | vs TEX | 2 | L 0-4 | 0-2 | 6 | 15,009 | Erik Hanson | Kevin Brown | Kevin Brown | Erik Hanson | | 10 | 16 | -6 |
| 1992-04-08 | vs TEX | 3 | L 1-13 | 0-3 | 6 | 13,597 | Russ Swan | Jose Guzman | Jose Guzman | Russ Swan | | 11 | 29 | -18 |
| 1992-04-09 | vs TEX | 4 | L 1-9 | 0-4 | 6 | 12,436 | Dave Fleming | Jeff Robinson | Jeff Robinson | Dave Fleming | | 12 | 38 | -26 |
| 1992-04-10 | vs KCA | 5 | W 9-3 | 1-4 | 5 | 17,043 | Rich DeLucia | Mark Davis | Rich DeLucia | Mark Davis | | 21 | 41 | -20 |
| 1992-04-11 | vs KCA | 6 | W 1-0 | 2-4 | 5 | 46,595 | Randy Johnson | Kevin Appier | Randy Johnson | Kevin Appier | | 22 | 41 | -19 |
| 1992-04-12 | vs KCA | 7 | W 2-1 | 3-4 | 5 | 15,681 | Erik Hanson | Mike Boddicker | Erik Hanson | Mike Boddicker | Mike Schooler | 24 | 42 | -18 |
| 1992-04-13 | @ CHA | 8 | L 0-1 | 3-5 | 6 | 42,290 | Russ Swan | Greg Hibbard | Greg Hibbard | Russ Swan | Bobby Thigpen | 24 | 43 | -19 |
| 1992-04-15 | @ CHA | 9 | W 6-0 | 4-5 | 4 | 21,311 | Dave Fleming | Kirk McCaskill | Dave Fleming | Kirk McCaskill | | 30 | 43 | -13 |
| 1992-04-16 | @ CHA | 10 | L 4-5 | 4-6 | 5 | 22,432 | Rich DeLucia | Alex Fernandez | Alex Fernandez | Rich DeLucia | | 34 | 48 | -14 |
| 1992-04-17 | @ MIL | 11 | L 1-5 | 4-7 | 6 | 10,174 | Erik Hanson | Bill Wegman | Bill Wegman | Erik Hanson | | 35 | 53 | -18 |
| 1992-04-18 | @ MIL | 12 | W 5-3 | 5-7 | 5 | 12,662 | Russ Swan | Chris Bosio | Russ Swan | Dan Plesac | Mike Schooler | 40 | 56 | -16 |
| 1992-04-19 | @ MIL | 13 | W 12-9 | 6-7 | 5 | 7,676 | Dave Fleming | Jaime Navarro | Calvin Jones | Bruce Ruffin | Mike Schooler | 52 | 65 | -13 |
| 1992-04-20 | vs MIN | 14 | W 2-0 | 7-7 | 5 | 30,512 | Randy Johnson | Kevin Tapani | Randy Johnson | Kevin Tapani | | 54 | 65 | -11 |
| 1992-04-21 | vs MIN | 15 | L 2-5 | 7-8 | 5 | 15,757 | Rich DeLucia | Pat Mahomes | Pat Mahomes | Rich DeLucia | Rick Aguilera | 56 | 70 | -14 |
| 1992-04-22 | vs MIN | 16 | L 1-8 | 7-9 | 5 | 16,442 | Erik Hanson | Bill Krueger | Bill Krueger | Erik Hanson | | 57 | 78 | -21 |
| 1992-04-23 | vs MIN | 17 | W 3-2 | 8-9 | 5 | 18,006 | Russ Swan | Scott Erickson | Russ Swan | Scott Erickson | Mike Schooler | 60 | 80 | -20 |
| 1992-04-24 | @ CAL | 18 | W 7-2 | 9-9 | 3 | 23,434 | Dave Fleming | Jim Abbott | Dave Fleming | Jim Abbott | | 67 | 82 | -15 |
| 1992-04-25 | @ CAL | 19 | W 10-6 | 10-9 | 3 | 31,116 | Randy Johnson | Joe Grahe | Randy Johnson | Joe Grahe | Mike Schooler | 77 | 88 | -11 |
| 1992-04-26 | @ CAL | 20 | L 5-7 | 10-10 | 4 | 36,119 | Erik Hanson | Mark Langston | Scott Bailes | Jeff Nelson | Bryan Harvey | 82 | 95 | -13 |
| 1992-04-28 | @ DET | 21 | L 1-4 | 10-11 | 5 | 9,304 | Russ Swan | Bill Gullickson | Bill Gullickson | Russ Swan | | 83 | 99 | -16 |
| 1992-05-01 | @ BAL | 22 | L 1-15 | 10-12 | 5 | 45,451 | Randy Johnson | Ben McDonald | Ben McDonald | Randy Johnson | | 84 | 114 | -30 |
| 1992-05-02 | @ BAL | 23 | L 2-4 | 10-13 | 6 | 41,358 | Erik Hanson | Rick Sutcliffe | Rick Sutcliffe | Erik Hanson | Gregg Olson | 86 | 118 | -32 |
| 1992-05-03 | @ BAL | 24 | L 6-8 | 10-14 | 6 | 45,352 | Rich DeLucia | Mike Mussina | Mike Mussina | Rich DeLucia | Gregg Olson | 92 | 126 | -34 |
| 1992-05-04 | vs NYA | 25 | L 5-7 | 10-15 | 6 | 14,494 | Russ Swan | Tim Leary | Tim Leary | Russ Swan | Steve Howe | 97 | 133 | -36 |
| 1992-05-05 | vs NYA | 26 | W 7-4 | 11-15 | 6 | 12,930 | Dave Fleming | Greg Cadaret | Dave Fleming | Greg Cadaret | | 104 | 137 | -33 |
| 1992-05-06 | vs TOR | 27 | L 4-12 | 11-16 | 6 | 12,771 | Randy Johnson | Jimmy Key | Jimmy Key | Randy Johnson | | 108 | 149 | -41 |
| 1992-05-07 | vs TOR | 28 | L 7-8 | 11-17 | 6 | 13,347 | Erik Hanson | Jack Morris | Pat Hentgen | Mike Schooler | Tom Henke | 115 | 157 | -42 |
| 1992-05-08 | vs DET | 29 | L 6-7 | 11-18 | 6 | 16,894 | Clay Parker | Eric King | Les Lancaster | Mike Schooler | Mike Henneman | 121 | 164 | -43 |
| 1992-05-09 | vs DET | 30 | L 0-13 | 11-19 | 6 | 40,455 | Russ Swan | Bill Gullickson | Bill Gullickson | Russ Swan | | 121 | 177 | -56 |
| 1992-05-10 | vs DET | 31 | W 6-2 | 12-19 | 6 | 15,662 | Dave Fleming | Scott Aldred | Dave Fleming | Scott Aldred | | 127 | 179 | -52 |
| 1992-05-12 | @ NYA | 32 | L 1-3 | 12-20 | 6 | 13,544 | Randy Johnson | Melido Perez | Melido Perez | Randy Johnson | Steve Howe | 128 | 182 | -54 |
| 1992-05-13 | @ NYA | 33 | L 4-12 | 12-21 | 6 | 12,596 | Erik Hanson | Scott Sanderson | Scott Sanderson | Erik Hanson | | 132 | 194 | -62 |
| 1992-05-14 | @ TOR | 34 | L 4-5 | 12-22 | 6 | 50,375 | Russ Swan | Dave Stieb | Dave Stieb | Calvin Jones | David Wells | 136 | 199 | -63 |
| 1992-05-15 | @ TOR | 35 | W 2-1 | 13-22 | 6 | 50,405 | Dave Fleming | Todd Stottlemyre | Dave Fleming | Todd Stottlemyre | Mike Schooler | 138 | 200 | -62 |
| 1992-05-16 | @ TOR | 36 | W 7-6 | 14-22 | 6 | 50,385 | Clay Parker | Juan Guzman | Dennis Powell | David Wells | Mike Schooler | 145 | 206 | -61 |
| 1992-05-17 | @ TOR | 37 | W 3-2 | 15-22 | 6 | 50,364 | Randy Johnson | Jimmy Key | Randy Johnson | Jimmy Key | Mike Schooler | 148 | 208 | -60 |
| 1992-05-18 | @ BOS | 38 | L 2-3 | 15-23 | 6 | 24,377 | Erik Hanson | Mike Gardiner | Mike Gardiner | Erik Hanson | Jeff Reardon | 150 | 211 | -61 |
| 1992-05-19 | @ BOS | 39 | L 5-7 | 15-24 | 6 | 27,091 | Russ Swan | Joe Hesketh | Tom Bolton | Jeff Nelson | Jeff Reardon | 155 | 218 | -63 |
| 1992-05-20 | @ BOS | 40 | L 4-6 | 15-25 | 6 | 32,055 | Dave Fleming | Roger Clemens | Roger Clemens | Dennis Powell | Jeff Reardon | 159 | 224 | -65 |
| 1992-05-22 | vs CLE | 41 | W 2-1 | 16-25 | 6 | 14,936 | Randy Johnson | Scott Scudder | Randy Johnson | Scott Scudder | Mike Schooler | 161 | 225 | -64 |
| 1992-05-23 | vs CLE | 42 | L 4-5 | 16-26 | 6 | 15,272 | Erik Hanson | Denis Boucher | Derek Lilliquist | Erik Hanson | Steve Olin | 165 | 230 | -65 |
| 1992-05-24 | vs CLE | 43 | W 5-4 | 17-26 | 6 | 14,089 | Clay Parker | Jack Armstrong | Calvin Jones | Steve Olin | | 170 | 234 | -64 |
| 1992-05-25 | vs BAL | 44 | W 7-3 | 18-26 | 6 | 25,847 | Dave Fleming | Jose Mesa | Dave Fleming | Jose Mesa | Mike Schooler | 177 | 237 | -60 |
| 1992-05-26 | vs BAL | 45 | L 8-13 | 18-27 | 6 | 11,389 | Randy Johnson | Rick Sutcliffe | Rick Sutcliffe | Randy Johnson | | 185 | 250 | -65 |
| 1992-05-27 | vs BAL | 46 | W 7-1 | 19-27 | 6 | 15,406 | Erik Hanson | Ben McDonald | Erik Hanson | Ben McDonald | | 192 | 251 | -59 |
| 1992-05-29 | vs BOS | 47 | W 7-3 | 20-27 | 6 | 18,270 | Clay Parker | John Dopson | Dennis Powell | John Dopson | | 199 | 254 | -55 |
| 1992-05-30 | vs BOS | 48 | W 3-0 | 21-27 | 6 | 40,484 | Dave Fleming | Mike Gardiner | Dave Fleming | Mike Gardiner | | 202 | 254 | -52 |
| 1992-05-31 | vs BOS | 49 | L 1-7 | 21-28 | 6 | 39,005 | Randy Johnson | Roger Clemens | Roger Clemens | Randy Johnson | | 203 | 261 | -58 |
| 1992-06-02 | @ CLE | 50 | L 3-4 | 21-29 | 5 | 7,265 | Erik Hanson | Dave Otto | Dave Otto | Erik Hanson | Steve Olin | 206 | 265 | -59 |
| 1992-06-03 | @ CLE | 51 | L 3-8 | 21-30 | 6 | 7,536 | Clay Parker | Scott Scudder | Scott Scudder | Clay Parker | | 209 | 273 | -64 |
| 1992-06-04 | @ CLE | 52 | W 10-3 | 22-30 | 6 | 5,022 | Dave Fleming | Denis Boucher | Dave Fleming | Denis Boucher | | 219 | 276 | -57 |
| 1992-06-05 | @ KCA | 53 | L 4-6 | 22-31 | 6 | 25,023 | Calvin Jones | Kevin Appier | Kevin Appier | Calvin Jones | Jeff Montgomery | 223 | 282 | -59 |
| 1992-06-06 | @ KCA | 54 | L 3-4 | 22-32 | 6 | 24,111 | Randy Kramer | Hipolito Pichardo | Neal Heaton | Mike Schooler | | 226 | 286 | -60 |
| 1992-06-07 | @ KCA | 55 | L 1-4 | 22-33 | 7 | 21,866 | Erik Hanson | Mike Boddicker | Rick Reed | Erik Hanson | Jeff Montgomery | 227 | 290 | -63 |
| 1992-06-08 | @ TEX | 56 | L 3-14 | 22-34 | 7 | 25,568 | Clay Parker | Kevin Brown | Kevin Brown | Clay Parker | | 230 | 304 | -74 |
| 1992-06-09 | @ TEX | 57 | W 2-1 | 23-34 | 6 | 42,273 | Dave Fleming | Todd Burns | Dave Fleming | Kenny Rogers | Mike Schooler | 232 | 305 | -73 |
| 1992-06-10 | @ TEX | 58 | L 3-5 | 23-35 | 6 | 35,378 | Randy Johnson | Jose Guzman | Jose Guzman | Randy Johnson | Jeff Russell | 235 | 310 | -75 |
| 1992-06-12 | vs MIL | 59 | W 4-1 | 24-35 | 6 | 17,787 | Erik Hanson | Jaime Navarro | Erik Hanson | Jaime Navarro | Russ Swan | 239 | 311 | -72 |
| 1992-06-13 | vs MIL | 60 | L 7-8 | 24-36 | 7 | 18,939 | Randy Kramer | Bill Wegman | Mike Fetters | Eric Gunderson | Doug Henry | 246 | 319 | -73 |
| 1992-06-14 | vs MIL | 61 | L 4-14 | 24-37 | 7 | 29,036 | Dave Fleming | Ricky Bones | Ricky Bones | Dave Fleming | | 250 | 333 | -83 |
| 1992-06-15 | vs CHA | 62 | W 4-1 | 25-37 | 7 | 27,188 | Rich DeLucia | Kirk McCaskill | Rich DeLucia | Kirk McCaskill | Russ Swan | 254 | 334 | -80 |
| 1992-06-16 | vs CHA | 63 | W 9-6 | 26-37 | 7 | 13,912 | Mike Walker | Alex Fernandez | Eric Gunderson | Scott Radinsky | Mike Schooler | 263 | 340 | -77 |
| 1992-06-17 | vs CHA | 64 | W 2-1 | 27-37 | 6 | 15,509 | Erik Hanson | Charlie Hough | Erik Hanson | Charlie Hough | Mike Schooler | 265 | 341 | -76 |
| 1992-06-18 | vs CHA | 65 | W 5-4 | 28-37 | 6 | 19,840 | Randy Kramer | Jack McDowell | Eric Gunderson | Wilson Alvarez | | 270 | 345 | -75 |
| 1992-06-19 | @ MIN | 66 | W 1-0 | 29-37 | 5 | 26,892 | Dave Fleming | Kevin Tapani | Dave Fleming | Kevin Tapani | | 271 | 345 | -74 |
| 1992-06-20 | @ MIN | 67 | L 3-5 | 29-38 | 6 | 41,405 | Rich DeLucia | Bill Krueger | Bill Krueger | Rich DeLucia | Rick Aguilera | 274 | 350 | -76 |
| 1992-06-21 | @ MIN | 68 | L 0-5 | 29-39 | 6 | 32,952 | Mike Walker | Willie Banks | Willie Banks | Mike Walker | Tom Edens | 274 | 355 | -81 |
| 1992-06-22 | @ OAK | 69 | L 2-7 | 29-40 | 6 | 23,067 | Erik Hanson | Ron Darling | Ron Darling | Erik Hanson | Dennis Eckersley | 276 | 362 | -86 |
| 1992-06-23 | @ OAK | 70 | L 7-12 | 29-41 | 7 | 27,963 | Randy Kramer | Joe Slusarski | Joe Slusarski | Randy Kramer | | 283 | 374 | -91 |
| 1992-06-24 | @ OAK | 71 | L 2-7 | 29-42 | 7 | 26,353 | Dave Fleming | Dave Stewart | Dave Stewart | Dave Fleming | | 285 | 381 | -96 |
| 1992-06-25 | vs CAL | 72 | W 13-4 | 30-42 | 6 | 14,219 | Rich DeLucia | Julio Valera | Rich DeLucia | Julio Valera | | 298 | 385 | -87 |
| 1992-06-26 | vs CAL | 73 | L 1-10 | 30-43 | 6 | 17,564 | Mike Walker | Jim Abbott | Jim Abbott | Mike Walker | | 299 | 395 | -96 |
| 1992-06-27 | vs CAL | 74 | L 1-2 | 30-44 | 7 | 29,171 | Randy Johnson | Mark Langston | Mark Langston | Randy Johnson | | 300 | 397 | -97 |
| 1992-06-28 | vs CAL | 75 | W 9-2 | 31-44 | 7 | 14,335 | Erik Hanson | Bert Blyleven | Erik Hanson | Bert Blyleven | | 309 | 399 | -90 |
| 1992-06-29 | vs OAK | 76 | L 4-5 | 31-45 | 7 | 21,463 | Dave Fleming | Dave Stewart | Vince Horsman | Mike Schooler | Dennis Eckersley | 313 | 404 | -91 |
| 1992-06-30 | vs OAK | 77 | L 2-4 | 31-46 | 7 | 18,843 | Rich DeLucia | Bob Welch | Bob Welch | Jeff Nelson | Dennis Eckersley | 315 | 408 | -93 |
| 1992-07-01 | vs OAK | 78 | L 1-3 | 31-47 | 7 | 21,127 | Mark Grant | Mike Moore | Mike Moore | Mark Grant | Dennis Eckersley | 316 | 411 | -95 |
| 1992-07-03 | @ DET | 79 | L 4-6 | 32-48 | 7 | 0 | Randy Johnson | Mark Leiter | Walt Terrell | Randy Johnson | Mike Henneman | 320 | 417 | -97 |
| 1992-07-03 | @ DET | 80 | W 11-0 | 32-48 | 7 | 19,686 | Erik Hanson | Les Lancaster | Erik Hanson | Les Lancaster | | 331 | 417 | -86 |
| 1992-07-04 | @ DET | 81 | W 4-3 | 33-48 | 6 | 13,532 | Dave Fleming | Frank Tanana | Mike Schooler | Mike Henneman | Russ Swan | 335 | 420 | -85 |
| 1992-07-05 | @ DET | 82 | L 5-8 | 33-49 | 6 | 18,251 | Rich DeLucia | Buddy Groom | Walt Terrell | Rich DeLucia | John Doherty | 340 | 428 | -88 |
| 1992-07-06 | @ DET | 83 | L 4-5 | 33-50 | 6 | 14,880 | Mark Grant | Bill Gullickson | John Kiely | Mike Walker | | 344 | 433 | -89 |
| 1992-07-07 | @ TOR | 84 | L 3-4 | 33-51 | 6 | 50,397 | Rich DeLucia | Pat Hentgen | Duane Ward | Jeff Nelson | | 347 | 437 | -90 |
| 1992-07-08 | @ TOR | 85 | L 0-6 | 33-52 | 6 | 50,391 | Erik Hanson | Jimmy Key | Jimmy Key | Erik Hanson | | 347 | 443 | -96 |
| 1992-07-09 | @ NYA | 86 | L 6-7 | 33-53 | 6 | 18,487 | Randy Johnson | Scott Kamieniecki | Scott Kamieniecki | Randy Johnson | John Habyan | 353 | 450 | -97 |
| 1992-07-10 | @ NYA | 87 | W 5-2 | 34-53 | 6 | 20,458 | Dave Fleming | Scott Sanderson | Dave Fleming | Scott Sanderson | Russ Swan | 358 | 452 | -94 |
| 1992-07-11 | @ NYA | 88 | W 5-3 | 35-53 | 6 | 39,533 | Juan Agosto | Curt Young | Russ Swan | John Habyan | | 363 | 455 | -92 |
| 1992-07-12 | @ NYA | 89 | W 7-6 | 36-53 | 6 | 45,041 | Mark Grant | Shawn Hillegas | Erik Hanson | Greg Cadaret | Russ Swan | 370 | 461 | -91 |
| 1992-07-16 | vs TOR | 90 | L 2-7 | 36-54 | 7 | 52,711 | Randy Johnson | Jack Morris | Jack Morris | Randy Johnson | | 372 | 468 | -96 |
| 1992-07-17 | vs TOR | 91 | W 8-6 | 37-54 | 7 | 24,160 | Erik Hanson | Jimmy Key | Erik Hanson | Jimmy Key | Russ Swan | 380 | 474 | -94 |
| 1992-07-18 | vs TOR | 92 | L 0-3 | 37-55 | 7 | 43,922 | Dave Fleming | Juan Guzman | Juan Guzman | Dave Fleming | Tom Henke | 380 | 477 | -97 |
| 1992-07-19 | vs TOR | 93 | L 4-8 | 37-56 | 7 | 28,560 | Rich DeLucia | David Wells | David Wells | Rich DeLucia | | 384 | 485 | -101 |
| 1992-07-20 | vs DET | 94 | L 4-6 | 37-57 | 7 | 25,351 | Mark Grant | Walt Terrell | Walt Terrell | Mark Grant | Kurt Knudsen | 388 | 491 | -103 |
| 1992-07-21 | vs DET | 95 | L 2-6 | 37-58 | 7 | 13,879 | Randy Johnson | Frank Tanana | Frank Tanana | Randy Johnson | | 390 | 497 | -107 |
| 1992-07-22 | vs DET | 96 | L 2-3 | 37-59 | 7 | 15,302 | Erik Hanson | Bill Gullickson | Bill Gullickson | Erik Hanson | Kurt Knudsen | 392 | 500 | -108 |
| 1992-07-23 | vs NYA | 97 | L 4-5 | 37-60 | 7 | 20,288 | Dave Fleming | Scott Kamieniecki | Tim Burke | Russ Swan | John Habyan | 396 | 505 | -109 |
| 1992-07-24 | vs NYA | 98 | L 7-8 | 37-61 | 7 | 23,526 | Brian Fisher | Curt Young | Steve Farr | Dennis Powell | | 403 | 513 | -110 |
| 1992-07-25 | vs NYA | 99 | W 8-2 | 38-61 | 7 | 28,206 | Mark Grant | Shawn Hillegas | Mark Grant | Shawn Hillegas | Jeff Nelson | 411 | 515 | -104 |
| 1992-07-26 | vs NYA | 100 | W 8-5 | 39-61 | 7 | 21,802 | Randy Johnson | Melido Perez | Randy Johnson | Melido Perez | Russ Swan | 419 | 520 | -101 |
| 1992-07-27 | @ CAL | 101 | L 0-3 | 39-62 | 7 | 19,658 | Erik Hanson | Chuck Finley | Chuck Finley | Erik Hanson | Joe Grahe | 419 | 523 | -104 |
| 1992-07-28 | @ CAL | 102 | W 8-1 | 40-62 | 7 | 19,509 | Dave Fleming | Mark Langston | Dave Fleming | Mark Langston | | 427 | 524 | -97 |
| 1992-07-29 | @ CAL | 103 | W 8-0 | 41-62 | 7 | 19,896 | Brian Fisher | Bert Blyleven | Brian Fisher | Bert Blyleven | | 435 | 524 | -89 |
| 1992-07-30 | @ CAL | 104 | L 5-6 | 41-63 | 7 | 23,546 | Mark Grant | Tim Fortugno | Mark Eichhorn | Russ Swan | Joe Grahe | 440 | 530 | -90 |
| 1992-07-31 | @ CHA | 105 | W 6-3 | 42-63 | 7 | 34,813 | Randy Johnson | Charlie Hough | Randy Johnson | Charlie Hough | Russ Swan | 446 | 533 | -87 |
| 1992-08-01 | @ CHA | 106 | L 1-8 | 42-64 | 7 | 42,761 | Erik Hanson | Kirk McCaskill | Kirk McCaskill | Erik Hanson | Greg Hibbard | 447 | 541 | -94 |
| 1992-08-02 | @ CHA | 107 | L 4-7 | 42-65 | 7 | 34,863 | Dave Fleming | Jack McDowell | Jack McDowell | Dave Fleming | Scott Radinsky | 451 | 548 | -97 |
| 1992-08-04 | @ MIL | 108 | L 2-5 | 42-66 | 7 | 20,213 | Brian Fisher | Chris Bosio | Chris Bosio | Brian Fisher | Doug Henry | 453 | 553 | -100 |
| 1992-08-05 | @ MIL | 109 | L 1-8 | 42-67 | 7 | 18,574 | Randy Johnson | Bill Wegman | Bill Wegman | Randy Johnson | | 454 | 561 | -107 |
| 1992-08-06 | @ MIL | 110 | L 2-4 | 42-68 | 7 | 25,427 | Mark Grant | Jaime Navarro | Jaime Navarro | Mark Grant | Doug Henry | 456 | 565 | -109 |
| 1992-08-07 | vs TEX | 111 | L 6-7 | 42-69 | 7 | 18,732 | Dave Fleming | Kevin Brown | Todd Burns | Russ Swan | Ed Nunez | 462 | 572 | -110 |
| 1992-08-08 | vs TEX | 112 | L 3-7 | 42-70 | 7 | 20,393 | Kerry Woodson | Jose Guzman | Jose Guzman | Kerry Woodson | | 465 | 579 | -114 |
| 1992-08-09 | vs TEX | 113 | W 6-5 | 43-70 | 7 | 16,037 | Brian Fisher | Brian Bohanon | Calvin Jones | Matt Whiteside | | 471 | 584 | -113 |
| 1992-08-10 | vs KCA | 114 | W 3-1 | 44-70 | 7 | 24,889 | Randy Johnson | Luis Aquino | Randy Johnson | Luis Aquino | | 474 | 585 | -111 |
| 1992-08-11 | vs KCA | 115 | L 6-9 | 44-71 | 7 | 12,691 | Erik Hanson | Hipolito Pichardo | Hipolito Pichardo | Erik Hanson | Jeff Montgomery | 480 | 594 | -114 |
| 1992-08-12 | vs KCA | 116 | W 6-3 | 45-71 | 7 | 15,983 | Dave Fleming | Dennis Moeller | Dave Fleming | Dennis Moeller | Jeff Nelson | 486 | 597 | -111 |
| 1992-08-14 | vs MIN | 117 | L 6-9 | 45-72 | 7 | 21,092 | Brian Fisher | Bill Krueger | David West | Calvin Jones | Rick Aguilera | 492 | 606 | -114 |
| 1992-08-15 | vs MIN | 118 | W 3-2 | 46-72 | 7 | 33,458 | Randy Johnson | Kevin Tapani | Randy Johnson | Tom Edens | | 495 | 608 | -113 |
| 1992-08-16 | vs MIN | 119 | W 8-7 | 47-72 | 7 | 21,452 | Erik Hanson | John Smiley | Jeff Nelson | Mark Guthrie | | 503 | 615 | -112 |
| 1992-08-18 | @ BAL | 120 | W 8-3 | 48-72 | 7 | 45,200 | Dave Fleming | Ben McDonald | Dave Fleming | Ben McDonald | Jeff Nelson | 511 | 618 | -107 |
| 1992-08-19 | @ BAL | 121 | W 10-8 | 49-72 | 7 | 41,149 | Mark Grant | Arthur Rhodes | Mark Grant | Arthur Rhodes | Russ Swan | 521 | 626 | -105 |
| 1992-08-20 | @ BAL | 122 | L 1-2 | 49-73 | 7 | 45,951 | Brian Fisher | Rick Sutcliffe | Storm Davis | Mike Schooler | | 522 | 628 | -106 |
| 1992-08-21 | @ BOS | 123 | W 5-2 | 50-73 | 7 | 33,444 | Randy Johnson | Frank Viola | Randy Johnson | Frank Viola | | 527 | 630 | -103 |
| 1992-08-22 | @ BOS | 124 | L 8-10 | 50-74 | 7 | 33,275 | Erik Hanson | Joe Hesketh | Greg Harris | Shawn Barton | Jeff Reardon | 535 | 640 | -105 |
| 1992-08-23 | @ BOS | 125 | W 9-3 | 51-74 | 7 | 33,365 | Tim Leary | Roger Clemens | Dennis Powell | Roger Clemens | | 544 | 643 | -99 |
| 1992-08-25 | vs CLE | 126 | W 6-0 | 52-74 | 7 | 14,015 | Dave Fleming | Charles Nagy | Dave Fleming | Charles Nagy | | 550 | 643 | -93 |
| 1992-08-26 | vs CLE | 127 | L 3-6 | 52-75 | 7 | 12,289 | Randy Johnson | Rod Nichols | Eric Plunk | Russ Swan | Steve Olin | 553 | 649 | -96 |
| 1992-08-27 | vs CLE | 128 | W 6-2 | 53-75 | 7 | 11,891 | Brian Fisher | Dennis Cook | Brian Fisher | Dennis Cook | | 559 | 651 | -92 |
| 1992-08-28 | vs BAL | 129 | W 6-4 | 54-75 | 7 | 14,738 | Tim Leary | Ben McDonald | Tim Leary | Ben McDonald | Jeff Nelson | 565 | 655 | -90 |
| 1992-08-29 | vs BAL | 130 | L 0-4 | 54-76 | 7 | 18,027 | Mark Grant | Arthur Rhodes | Arthur Rhodes | Mark Grant | Gregg Olson | 565 | 659 | -94 |
| 1992-08-30 | vs BAL | 131 | L 0-2 | 54-77 | 7 | 17,504 | Dave Fleming | Rick Sutcliffe | Rick Sutcliffe | Dave Fleming | Gregg Olson | 565 | 661 | -96 |
| 1992-08-31 | vs BOS | 132 | W 15-2 | 55-77 | 7 | 14,017 | Randy Johnson | Frank Viola | Randy Johnson | Frank Viola | | 580 | 663 | -83 |
| 1992-09-01 | vs BOS | 133 | W 4-3 | 56-77 | 7 | 12,458 | Brian Fisher | Matt Young | Mike Schooler | Greg Harris | | 584 | 666 | -82 |
| 1992-09-02 | vs BOS | 134 | L 3-5 | 56-78 | 7 | 14,717 | Tim Leary | Roger Clemens | Roger Clemens | Tim Leary | | 587 | 671 | -84 |
| 1992-09-04 | @ CLE | 135 | L 0-7 | 56-79 | 7 | 9,933 | Dave Fleming | Jose Mesa | Jose Mesa | Dave Fleming | | 587 | 678 | -91 |
| 1992-09-05 | @ CLE | 136 | L 4-5 | 56-80 | 7 | 11,270 | Randy Johnson | Charles Nagy | Eric Plunk | Russ Swan | | 591 | 683 | -92 |
| 1992-09-06 | @ CLE | 137 | L 9-12 | 56-81 | 7 | 13,483 | Brian Fisher | Rod Nichols | Steve Olin | Mike Schooler | | 600 | 695 | -95 |
| 1992-09-07 | @ MIN | 138 | L 2-4 | 56-82 | 7 | 27,408 | Tim Leary | Scott Erickson | Scott Erickson | Tim Leary | Rick Aguilera | 602 | 699 | -97 |
| 1992-09-08 | @ MIN | 139 | L 4-8 | 56-83 | 7 | 17,865 | Mark Grant | Pat Mahomes | Gary Wayne | Calvin Jones | | 606 | 707 | -101 |
| 1992-09-09 | @ MIN | 140 | L 2-6 | 56-84 | 7 | 14,279 | Dave Fleming | Kevin Tapani | Kevin Tapani | Dave Fleming | Mark Guthrie | 608 | 713 | -105 |
| 1992-09-10 | @ OAK | 141 | L 4-6 | 56-85 | 7 | 18,745 | Randy Johnson | Ron Darling | Ron Darling | Randy Johnson | Dennis Eckersley | 612 | 719 | -107 |
| 1992-09-11 | @ OAK | 142 | L 3-4 | 56-86 | 7 | 29,177 | Brian Fisher | Bobby Witt | Jeff Russell | Jeff Nelson | | 615 | 723 | -108 |
| 1992-09-12 | @ OAK | 143 | L 4-5 | 56-87 | 7 | 30,159 | Tim Leary | Mike Moore | Mike Moore | Tim Leary | Dennis Eckersley | 619 | 728 | -109 |
| 1992-09-13 | @ OAK | 144 | L 1-3 | 56-88 | 7 | 28,088 | Erik Hanson | Bob Welch | Kelly Downs | Erik Hanson | Jeff Russell | 620 | 731 | -111 |
| 1992-09-15 | vs CAL | 145 | L 0-9 | 56-89 | 7 | 10,999 | Dave Fleming | Chuck Finley | Chuck Finley | Dave Fleming | | 620 | 740 | -120 |
| 1992-09-16 | vs CAL | 146 | L 1-2 | 56-90 | 7 | 11,532 | Randy Johnson | Mark Langston | Joe Grahe | Calvin Jones | Steve Frey | 621 | 742 | -121 |
| 1992-09-18 | vs OAK | 147 | L 4-7 | 56-91 | 7 | 39,508 | Brian Fisher | Mike Moore | Mike Moore | Brian Fisher | Dennis Eckersley | 625 | 749 | -124 |
| 1992-09-19 | vs OAK | 148 | W 6-4 | 57-91 | 7 | 17,517 | Tim Leary | Bob Welch | Tim Leary | Bob Welch | Jeff Nelson | 631 | 753 | -122 |
| 1992-09-20 | vs OAK | 149 | L 2-4 | 57-92 | 7 | 15,295 | Erik Hanson | Dave Stewart | Dave Stewart | Erik Hanson | Dennis Eckersley | 633 | 757 | -124 |
| 1992-09-21 | @ KCA | 150 | L 0-3 | 57-93 | 7 | 17,105 | Dave Fleming | Luis Aquino | Luis Aquino | Dave Fleming | Jeff Montgomery | 633 | 760 | -127 |
| 1992-09-22 | @ KCA | 151 | L 0-3 | 57-94 | 7 | 16,172 | Randy Johnson | Chris Haney | Chris Haney | Randy Johnson | | 633 | 763 | -130 |
| 1992-09-23 | @ KCA | 152 | W 6-1 | 58-94 | 7 | 15,338 | Brian Fisher | Hipolito Pichardo | Brian Fisher | Hipolito Pichardo | | 639 | 764 | -125 |
| 1992-09-24 | @ KCA | 153 | L 0-2 | 58-95 | 7 | 17,915 | Tim Leary | Dennis Rasmussen | Dennis Rasmussen | Tim Leary | Jeff Montgomery | 639 | 766 | -127 |
| 1992-09-25 | @ TEX | 154 | W 4-3 | 59-95 | 7 | 19,822 | Erik Hanson | Jose Guzman | Dennis Powell | Dan Smith | Brian Fisher | 643 | 769 | -126 |
| 1992-09-26 | @ TEX | 155 | W 8-4 | 60-95 | 7 | 31,122 | Dave Fleming | Roger Pavlik | Dave Fleming | Roger Pavlik | | 651 | 773 | -122 |
| 1992-09-27 | @ TEX | 156 | L 2-3 | 60-96 | 7 | 27,538 | Randy Johnson | Nolan Ryan | Matt Whiteside | Jeff Nelson | | 653 | 776 | -123 |
| 1992-09-29 | vs MIL | 157 | L 4-7 | 60-97 | 7 | 9,916 | Brian Fisher | Cal Eldred | Cal Eldred | Brian Fisher | Darren Holmes | 657 | 783 | -126 |
| 1992-09-30 | vs MIL | 158 | W 7-4 | 61-97 | 7 | 10,240 | Tim Leary | Chris Bosio | Tim Leary | Chris Bosio | Rich DeLucia | 664 | 787 | -123 |
| 1992-10-01 | vs MIL | 159 | L 2-7 | 61-98 | 7 | 9,863 | Erik Hanson | Bill Wegman | Bill Wegman | Jeff Nelson | | 666 | 794 | -128 |
| 1992-10-02 | vs CHA | 160 | W 2-0 | 62-98 | 7 | 26,770 | Dave Fleming | Charlie Hough | Dave Fleming | Charlie Hough | | 668 | 794 | -126 |
| 1992-10-03 | vs CHA | 161 | W 7-2 | 63-98 | 7 | 14,866 | Randy Johnson | Kirk McCaskill | Randy Johnson | Kirk McCaskill | | 675 | 796 | -121 |
| 1992-10-04 | vs CHA | 162 | W 4-3 | 64-98 | 7 | 15,591 | Brian Fisher | Jack McDowell | Brian Fisher | Jack McDowell | Jeff Nelson | 679 | 799 | -120 |