| 1991-04-08 | vs HOU | 1 | W 6-2 | 1-0 | 1 | 55,205 | Tom Browning | Mike Scott | Tom Browning | Mike Scott | Rob Dibble | 6 | 2 | 4 |
| 1991-04-10 | vs HOU | 2 | W 6-5 | 2-0 | 1 | 17,785 | Jose Rijo | Jim Deshaies | Ted Power | Darryl Kile | Randy Myers | 12 | 7 | 5 |
| 1991-04-11 | vs HOU | 3 | L 1-4 | 2-1 | 2 | 18,012 | Norm Charlton | Pete Harnisch | Pete Harnisch | Norm Charlton | Curt Schilling | 13 | 11 | 2 |
| 1991-04-13 | vs ATL | 4 | L 5-7 | 2-2 | 2 | 18,566 | Jack Armstrong | Steve Avery | Steve Avery | Jack Armstrong | Juan Berenguer | 18 | 18 | 0 |
| 1991-04-14 | vs ATL | 5 | L 1-12 | 2-3 | 4 | 25,837 | Tom Browning | Tom Glavine | Tom Glavine | Tom Browning | | 19 | 30 | -11 |
| 1991-04-15 | @ SDN | 6 | L 2-3 | 2-4 | 5 | 18,815 | Jose Rijo | Bruce Hurst | Mike Maddux | Ted Power | | 21 | 33 | -12 |
| 1991-04-16 | @ SDN | 7 | W 1-0 | 3-4 | 4 | 19,752 | Norm Charlton | Andy Benes | Norm Charlton | Andy Benes | Randy Myers | 22 | 33 | -11 |
| 1991-04-17 | @ SDN | 8 | W 5-1 | 4-4 | 3 | 18,014 | Chris Hammond | Greg Harris | Chris Hammond | Greg Harris | Scott Scudder | 27 | 34 | -7 |
| 1991-04-19 | @ ATL | 9 | W 8-3 | 5-4 | 2 | 13,498 | Jack Armstrong | Tom Glavine | Jack Armstrong | Tom Glavine | | 35 | 37 | -2 |
| 1991-04-20 | @ ATL | 10 | W 3-0 | 6-4 | 2 | 27,464 | Tom Browning | John Smoltz | Tom Browning | John Smoltz | | 38 | 37 | 1 |
| 1991-04-21 | @ ATL | 11 | L 2-3 | 6-5 | 2 | 23,473 | Jose Rijo | Charlie Leibrandt | Charlie Leibrandt | Jose Rijo | Kent Mercker | 40 | 40 | 0 |
| 1991-04-22 | @ HOU | 12 | L 1-2 | 6-6 | 2 | 8,692 | Norm Charlton | Xavier Hernandez | Dwayne Henry | Randy Myers | | 41 | 42 | -1 |
| 1991-04-23 | @ HOU | 13 | W 3-1 | 7-6 | 2 | 9,232 | Chris Hammond | Jimmy Jones | Chris Hammond | Jim Corsi | Rob Dibble | 44 | 43 | 1 |
| 1991-04-24 | @ HOU | 14 | L 0-1 | 7-7 | 2 | 10,869 | Jack Armstrong | Darryl Kile | Dwayne Henry | Scott Scudder | | 44 | 44 | 0 |
| 1991-04-25 | vs CHN | 15 | W 6-4 | 8-7 | 2 | 22,914 | Tom Browning | Greg Maddux | Ted Power | Heathcliff Slocumb | Randy Myers | 50 | 48 | 2 |
| 1991-04-26 | vs CHN | 16 | W 3-1 | 9-7 | 2 | 37,681 | Jose Rijo | Mike Harkey | Jose Rijo | Mike Harkey | Rob Dibble | 53 | 49 | 4 |
| 1991-04-27 | vs CHN | 17 | L 3-8 | 9-8 | 3 | 35,265 | Norm Charlton | Shawn Boskie | Shawn Boskie | Norm Charlton | Paul Assenmacher | 56 | 57 | -1 |
| 1991-04-28 | vs CHN | 18 | W 4-3 | 10-8 | 2 | 33,518 | Chris Hammond | Rick Sutcliffe | Chris Hammond | Rick Sutcliffe | Rob Dibble | 60 | 60 | 0 |
| 1991-04-30 | vs PIT | 19 | W 4-3 | 11-8 | 1 | 20,627 | Tom Browning | Doug Drabek | Tom Browning | Doug Drabek | Rob Dibble | 64 | 63 | 1 |
| 1991-05-01 | vs PIT | 20 | L 4-6 | 11-9 | 1 | 25,231 | Jose Rijo | Vicente Palacios | Stan Belinda | Randy Myers | Bill Landrum | 68 | 69 | -1 |
| 1991-05-03 | vs SLN | 21 | L 2-4 | 11-10 | 1 | 33,643 | Norm Charlton | Ken Hill | Cris Carpenter | Scott Scudder | Lee Smith | 70 | 73 | -3 |
| 1991-05-04 | vs SLN | 22 | W 3-1 | 12-10 | 1 | 39,008 | Jack Armstrong | Jamie Moyer | Jack Armstrong | Jamie Moyer | Rob Dibble | 73 | 74 | -1 |
| 1991-05-05 | vs SLN | 23 | W 4-2 | 13-10 | 1 | 24,758 | Tom Browning | Jose DeLeon | Tom Browning | Lee Smith | Rob Dibble | 77 | 76 | 1 |
| 1991-05-06 | @ PIT | 24 | L 1-3 | 13-11 | 2 | 9,518 | Jose Rijo | Vicente Palacios | Vicente Palacios | Jose Rijo | Bill Landrum | 78 | 79 | -1 |
| 1991-05-07 | @ PIT | 25 | L 2-7 | 13-12 | 3 | 14,258 | Chris Hammond | Randy Tomlin | Randy Tomlin | Chris Hammond | Stan Belinda | 80 | 86 | -6 |
| 1991-05-08 | @ PIT | 26 | L 2-7 | 13-13 | 3 | 14,594 | Norm Charlton | Zane Smith | Zane Smith | Norm Charlton | | 82 | 93 | -11 |
| 1991-05-10 | @ CHN | 27 | L 5-6 | 13-14 | 4 | 35,484 | Tom Browning | Rick Sutcliffe | Rick Sutcliffe | Tom Browning | Dave Smith | 87 | 99 | -12 |
| 1991-05-11 | @ CHN | 28 | W 12-2 | 14-14 | 3 | 35,998 | Jose Rijo | Mike Bielecki | Jose Rijo | Mike Bielecki | | 99 | 101 | -2 |
| 1991-05-12 | @ CHN | 29 | W 5-3 | 15-14 | 2 | 32,353 | Jack Armstrong | Greg Maddux | Jack Armstrong | Greg Maddux | Rob Dibble | 104 | 104 | 0 |
| 1991-05-13 | @ SLN | 30 | L 0-1 | 15-15 | 3 | 29,271 | Chris Hammond | Ken Hill | Ken Hill | Randy Myers | Lee Smith | 104 | 105 | -1 |
| 1991-05-14 | @ SLN | 31 | W 3-1 | 16-15 | 3 | 24,672 | Norm Charlton | Jamie Moyer | Norm Charlton | Jamie Moyer | Rob Dibble | 107 | 106 | 1 |
| 1991-05-15 | @ SLN | 32 | L 2-8 | 16-16 | 3 | 34,953 | Tom Browning | Bob Tewksbury | Bob Tewksbury | Tom Browning | | 109 | 114 | -5 |
| 1991-05-17 | vs SDN | 33 | W 7-3 | 17-16 | 3 | 30,119 | Jose Rijo | Bruce Hurst | Randy Myers | Bruce Hurst | Rob Dibble | 116 | 117 | -1 |
| 1991-05-18 | vs SDN | 34 | L 2-5 | 17-17 | 3 | 38,495 | Jack Armstrong | Adam Peterson | Adam Peterson | Jack Armstrong | | 118 | 122 | -4 |
| 1991-05-19 | vs SDN | 35 | L 2-3 | 17-18 | 4 | 29,847 | Norm Charlton | Andy Benes | Andy Benes | Norm Charlton | Craig Lefferts | 120 | 125 | -5 |
| 1991-05-21 | vs SFN | 36 | W 3-2 | 18-18 | 3 | 27,358 | Tom Browning | Buddy Black | Tom Browning | Buddy Black | Rob Dibble | 123 | 127 | -4 |
| 1991-05-22 | vs SFN | 37 | W 9-4 | 19-18 | 3 | 23,053 | Jose Rijo | Don Robinson | Jose Rijo | Don Robinson | | 132 | 131 | 1 |
| 1991-05-23 | vs SFN | 38 | W 6-2 | 20-18 | 3 | 25,173 | Jack Armstrong | Trevor Wilson | Jack Armstrong | Trevor Wilson | | 138 | 133 | 5 |
| 1991-05-24 | vs LAN | 39 | L 3-11 | 20-19 | 3 | 44,509 | Chris Hammond | Ramon Martinez | Ramon Martinez | Chris Hammond | | 141 | 144 | -3 |
| 1991-05-25 | vs LAN | 40 | L 1-8 | 20-20 | 4 | 38,260 | Norm Charlton | Kevin Gross | Kevin Gross | Norm Charlton | | 142 | 152 | -10 |
| 1991-05-26 | vs LAN | 41 | W 3-0 | 21-20 | 3 | 38,939 | Tom Browning | Bob Ojeda | Tom Browning | Bob Ojeda | Randy Myers | 145 | 152 | -7 |
| 1991-05-27 | @ SFN | 42 | W 3-2 | 22-20 | 3 | 20,037 | Jose Rijo | Don Robinson | Jose Rijo | Don Robinson | Rob Dibble | 148 | 154 | -6 |
| 1991-05-28 | @ SFN | 43 | L 2-6 | 22-21 | 3 | 12,103 | Jack Armstrong | Trevor Wilson | Trevor Wilson | Jack Armstrong | | 150 | 160 | -10 |
| 1991-05-29 | @ SFN | 44 | L 1-6 | 22-22 | 3 | 19,704 | Chris Hammond | John Burkett | Francisco Oliveras | Chris Hammond | | 151 | 166 | -15 |
| 1991-05-30 | @ LAN | 45 | W 7-2 | 23-22 | 3 | 29,796 | Scott Scudder | Ramon Martinez | Scott Scudder | Ramon Martinez | | 158 | 168 | -10 |
| 1991-05-31 | @ LAN | 46 | L 4-7 | 23-23 | 3 | 44,005 | Tom Browning | Bob Ojeda | Bob Ojeda | Tom Browning | | 162 | 175 | -13 |
| 1991-06-01 | @ LAN | 47 | W 6-5 | 24-23 | 3 | 45,974 | Jose Rijo | Mike Morgan | Randy Myers | Jay Howell | Rob Dibble | 168 | 180 | -12 |
| 1991-06-02 | @ LAN | 48 | L 1-4 | 24-24 | 4 | 43,683 | Jack Armstrong | Tim Belcher | Tim Belcher | Jack Armstrong | Tim Crews | 169 | 184 | -15 |
| 1991-06-04 | vs NYN | 49 | L 2-4 | 24-25 | 4 | 24,670 | Chris Hammond | David Cone | David Cone | Chris Hammond | John Franco | 171 | 188 | -17 |
| 1991-06-05 | vs NYN | 50 | W 11-10 | 25-25 | 4 | 22,859 | Tom Browning | Dwight Gooden | Tom Browning | Dwight Gooden | Rob Dibble | 182 | 198 | -16 |
| 1991-06-06 | vs NYN | 51 | W 5-3 | 26-25 | 4 | 27,667 | Jose Rijo | Frank Viola | Ted Power | Frank Viola | Randy Myers | 187 | 201 | -14 |
| 1991-06-07 | vs PHI | 52 | L 4-5 | 26-26 | 4 | 35,827 | Jack Armstrong | Tommy Greene | Tommy Greene | Jack Armstrong | Mitch Williams | 191 | 206 | -15 |
| 1991-06-08 | vs PHI | 53 | L 1-4 | 26-27 | 4 | 37,457 | Chris Hammond | Jose De Jesus | Jose De Jesus | Chris Hammond | Roger McDowell | 192 | 210 | -18 |
| 1991-06-09 | vs PHI | 54 | W 6-3 | 27-27 | 4 | 29,748 | Tom Browning | Terry Mulholland | Tom Browning | Terry Mulholland | Rob Dibble | 198 | 213 | -15 |
| 1991-06-10 | vs PHI | 55 | W 9-3 | 28-27 | 4 | 27,567 | Jose Rijo | Andy Ashby | Jose Rijo | Andy Ashby | | 207 | 216 | -9 |
| 1991-06-11 | @ MON | 56 | W 6-1 | 29-27 | 3 | 14,117 | Norm Charlton | Chris Nabholz | Norm Charlton | Chris Nabholz | | 213 | 217 | -4 |
| 1991-06-12 | @ MON | 57 | L 9-10 | 29-28 | 4 | 11,684 | Jack Armstrong | Oil Can Boyd | Scott Ruskin | Randy Myers | Jeff Fassero | 222 | 227 | -5 |
| 1991-06-13 | @ MON | 58 | W 3-2 | 30-28 | 3 | 12,279 | Chris Hammond | Brian Barnes | Chris Hammond | Brian Barnes | Rob Dibble | 225 | 229 | -4 |
| 1991-06-14 | @ PHI | 59 | W 4-2 | 31-28 | 3 | 26,067 | Tom Browning | Terry Mulholland | Tom Browning | Terry Mulholland | Rob Dibble | 229 | 231 | -2 |
| 1991-06-15 | @ PHI | 60 | W 3-1 | 32-28 | 3 | 32,075 | Jose Rijo | Andy Ashby | Jose Rijo | Andy Ashby | Rob Dibble | 232 | 232 | 0 |
| 1991-06-16 | @ PHI | 61 | W 8-6 | 33-28 | 2 | 41,905 | Norm Charlton | Pat Combs | Randy Myers | Roger McDowell | Don Carman | 240 | 238 | 2 |
| 1991-06-17 | @ NYN | 62 | L 6-10 | 33-29 | 2 | 29,892 | Scott Scudder | Ron Darling | Ron Darling | Scott Scudder | | 246 | 248 | -2 |
| 1991-06-18 | @ NYN | 63 | L 5-7 | 33-30 | 2 | 21,058 | Tom Browning | Wally Whitehurst | Alejandro Pena | Randy Myers | | 251 | 255 | -4 |
| 1991-06-19 | @ NYN | 64 | W 7-6 | 34-30 | 2 | 22,206 | Chris Hammond | David Cone | Kip Gross | David Cone | Rob Dibble | 258 | 261 | -3 |
| 1991-06-20 | vs MON | 65 | L 0-1 | 34-31 | 2 | 26,429 | Jose Rijo | Dennis Martinez | Barry Jones | Don Carman | Scott Ruskin | 258 | 262 | -4 |
| 1991-06-21 | vs MON | 66 | W 7-3 | 35-31 | 2 | 32,110 | Scott Scudder | Chris Haney | Scott Scudder | Chris Haney | | 265 | 265 | 0 |
| 1991-06-22 | vs MON | 67 | L 4-7 | 35-32 | 2 | 32,994 | Jack Armstrong | Oil Can Boyd | Oil Can Boyd | Jack Armstrong | Barry Jones | 269 | 272 | -3 |
| 1991-06-23 | vs MON | 68 | W 8-4 | 36-32 | 2 | 37,771 | Tom Browning | Brian Barnes | Randy Myers | Bill Sampen | | 277 | 276 | 1 |
| 1991-06-25 | vs SDN | 69 | W 8-2 | 37-32 | 2 | 26,583 | Chris Hammond | Andy Benes | Chris Hammond | Andy Benes | | 285 | 278 | 7 |
| 1991-06-26 | vs SDN | 70 | W 6-2 | 38-32 | 2 | 30,119 | Scott Scudder | Dennis Rasmussen | Scott Scudder | Dennis Rasmussen | Randy Myers | 291 | 280 | 11 |
| 1991-06-27 | vs SDN | 71 | W 3-0 | 39-32 | 2 | 31,014 | Jack Armstrong | Jose Melendez | Jack Armstrong | Jose Melendez | Rob Dibble | 294 | 280 | 14 |
| 1991-06-28 | vs HOU | 72 | W 8-5 | 40-32 | 2 | 33,157 | Tom Browning | Jim Deshaies | Tom Browning | Jim Deshaies | Rob Dibble | 302 | 285 | 17 |
| 1991-06-29 | vs HOU | 73 | L 2-6 | 40-33 | 2 | 42,608 | Gino Minutelli | Darryl Kile | Darryl Kile | Don Carman | Jim Clancy | 304 | 291 | 13 |
| 1991-06-30 | vs HOU | 74 | W 5-4 | 41-33 | 2 | 31,775 | Chris Hammond | Pete Harnisch | Chris Hammond | Pete Harnisch | Rob Dibble | 309 | 295 | 14 |
| 1991-07-02 | @ ATL | 75 | W 6-3 | 42-33 | 2 | 22,056 | Jack Armstrong | Charlie Leibrandt | Jack Armstrong | Charlie Leibrandt | | 315 | 298 | 17 |
| 1991-07-03 | @ ATL | 76 | L 6-8 | 42-34 | 2 | 20,279 | Tom Browning | Steve Avery | Steve Avery | Tim Layana | Juan Berenguer | 321 | 306 | 15 |
| 1991-07-04 | @ ATL | 77 | W 10-4 | 43-34 | 2 | 42,153 | Kip Gross | Pete Smith | Kip Gross | Pete Smith | | 331 | 310 | 21 |
| 1991-07-05 | @ HOU | 78 | W 1-0 | 44-34 | 2 | 24,117 | Chris Hammond | Pete Harnisch | Chris Hammond | Pete Harnisch | Rob Dibble | 332 | 310 | 22 |
| 1991-07-06 | @ HOU | 79 | L 0-3 | 44-35 | 2 | 31,452 | Jack Armstrong | Jimmy Jones | Jimmy Jones | Jack Armstrong | | 332 | 313 | 19 |
| 1991-07-07 | @ HOU | 80 | L 3-7 | 44-36 | 2 | 20,790 | Tom Browning | Mark Portugal | Mark Portugal | Tom Browning | | 335 | 320 | 15 |
| 1991-07-11 | vs PIT | 81 | L 6-10 | 44-37 | 2 | 35,159 | Chris Hammond | Zane Smith | Vicente Palacios | Randy Myers | | 341 | 330 | 11 |
| 1991-07-12 | vs PIT | 82 | L 2-7 | 44-38 | 2 | 42,181 | Jack Armstrong | Doug Drabek | Doug Drabek | Jack Armstrong | | 343 | 337 | 6 |
| 1991-07-13 | vs PIT | 83 | L 2-5 | 44-39 | 2 | 48,857 | Tom Browning | John Smiley | John Smiley | Tom Browning | Bob Kipper | 345 | 342 | 3 |
| 1991-07-14 | vs PIT | 84 | L 6-10 | 44-40 | 2 | 42,573 | Kip Gross | Bob Walk | Bob Walk | Kip Gross | Bob Patterson | 351 | 352 | -1 |
| 1991-07-15 | vs SLN | 85 | L 2-5 | 44-41 | 2 | 29,710 | Gino Minutelli | Omar Olivares | Omar Olivares | Gino Minutelli | Lee Smith | 353 | 357 | -4 |
| 1991-07-16 | vs SLN | 86 | L 7-8 | 44-42 | 3 | 28,082 | Chris Hammond | Jose DeLeon | Willie Fraser | Rob Dibble | Lee Smith | 360 | 365 | -5 |
| 1991-07-17 | vs SLN | 87 | L 5-6 | 44-43 | 3 | 30,239 | Jack Armstrong | Bryn Smith | Bryn Smith | Jack Armstrong | Lee Smith | 365 | 371 | -6 |
| 1991-07-19 | @ PIT | 88 | L 2-7 | 44-44 | 3 | 38,318 | Tom Browning | John Smiley | John Smiley | Tom Browning | | 367 | 378 | -11 |
| 1991-07-20 | @ PIT | 89 | W 3-2 | 45-44 | 3 | 34,805 | Kip Gross | Bob Walk | Kip Gross | Bob Walk | Ted Power | 370 | 380 | -10 |
| 1991-07-21 | @ PIT | 90 | L 0-6 | 45-45 | 3 | 34,717 | Chris Hammond | Randy Tomlin | Randy Tomlin | Chris Hammond | | 370 | 386 | -16 |
| 1991-07-23 | @ CHN | 91 | L 5-8 | 45-46 | 3 | 34,458 | Randy Myers | Les Lancaster | Les Lancaster | Randy Myers | Paul Assenmacher | 375 | 394 | -19 |
| 1991-07-24 | @ CHN | 92 | W 12-3 | 46-46 | 3 | 36,215 | Tom Browning | Mike Bielecki | Tom Browning | Mike Bielecki | | 387 | 397 | -10 |
| 1991-07-25 | @ CHN | 93 | L 4-5 | 46-47 | 3 | 35,008 | Jose Rijo | Greg Maddux | Heathcliff Slocumb | Tim Layana | | 391 | 402 | -11 |
| 1991-07-26 | @ SLN | 94 | L 1-5 | 46-48 | 3 | 44,472 | Chris Hammond | Bob Tewksbury | Bob Tewksbury | Chris Hammond | | 392 | 407 | -15 |
| 1991-07-27 | @ SLN | 95 | W 13-1 | 47-48 | 3 | 47,252 | Kip Gross | Omar Olivares | Kip Gross | Omar Olivares | | 405 | 408 | -3 |
| 1991-07-28 | @ SLN | 96 | L 2-3 | 47-49 | 3 | 38,148 | Randy Myers | Jose DeLeon | Jose DeLeon | Randy Myers | Lee Smith | 407 | 411 | -4 |
| 1991-07-30 | vs CHN | 97 | W 6-5 | 48-49 | 3 | 37,832 | Tom Browning | Greg Maddux | Rob Dibble | Chuck McElroy | | 413 | 416 | -3 |
| 1991-07-31 | vs CHN | 98 | W 5-1 | 49-49 | 3 | 36,483 | Jose Rijo | Frank Castillo | Jose Rijo | Frank Castillo | Ted Power | 418 | 417 | 1 |
| 1991-08-01 | vs SFN | 99 | L 1-8 | 49-50 | 3 | 30,351 | Kip Gross | Paul McClellan | Paul McClellan | Kip Gross | | 419 | 425 | -6 |
| 1991-08-02 | vs SFN | 100 | W 5-4 | 50-50 | 3 | 33,987 | Randy Myers | Buddy Black | Randy Myers | Buddy Black | Norm Charlton | 424 | 429 | -5 |
| 1991-08-03 | vs SFN | 101 | L 3-7 | 50-51 | 3 | 46,969 | Jack Armstrong | John Burkett | John Burkett | Jack Armstrong | | 427 | 436 | -9 |
| 1991-08-04 | vs SFN | 102 | W 6-5 | 51-51 | 3 | 36,951 | Tom Browning | Trevor Wilson | Ted Power | Jeff Brantley | | 433 | 441 | -8 |
| 1991-08-05 | vs LAN | 103 | W 10-6 | 52-51 | 3 | 34,997 | Jose Rijo | Ramon Martinez | Jose Rijo | Ramon Martinez | Rob Dibble | 443 | 447 | -4 |
| 1991-08-06 | vs LAN | 104 | L 2-5 | 52-52 | 3 | 33,271 | Kip Gross | Orel Hershiser | Orel Hershiser | Kip Gross | Roger McDowell | 445 | 452 | -7 |
| 1991-08-07 | vs LAN | 105 | L 0-2 | 52-53 | 3 | 37,016 | Randy Myers | Bob Ojeda | Bob Ojeda | Randy Myers | Roger McDowell | 445 | 454 | -9 |
| 1991-08-08 | vs LAN | 106 | L 4-6 | 52-54 | 3 | 37,581 | Tom Browning | Mike Morgan | Mike Morgan | Tom Browning | | 449 | 460 | -11 |
| 1991-08-09 | @ SDN | 107 | W 5-1 | 53-54 | 3 | 29,665 | Mo Sanford | Dennis Rasmussen | Mo Sanford | Dennis Rasmussen | | 454 | 461 | -7 |
| 1991-08-10 | @ SDN | 108 | L 0-1 | 53-55 | 4 | 36,861 | Jose Rijo | Greg Harris | Greg Harris | Jose Rijo | | 454 | 462 | -8 |
| 1991-08-11 | @ SDN | 109 | L 0-13 | 53-56 | 5 | 17,889 | Kip Gross | Ricky Bones | Ricky Bones | Kip Gross | | 454 | 475 | -21 |
| 1991-08-12 | @ LAN | 110 | L 2-3 | 53-57 | 5 | 42,056 | Randy Myers | Bob Ojeda | Roger McDowell | Rob Dibble | | 456 | 478 | -22 |
| 1991-08-13 | @ LAN | 111 | W 4-3 | 54-57 | 5 | 41,202 | Tom Browning | Mike Morgan | Rob Dibble | Roger McDowell | | 460 | 481 | -21 |
| 1991-08-14 | @ LAN | 112 | L 1-4 | 54-58 | 5 | 41,787 | Mo Sanford | Tim Belcher | Tim Belcher | Mo Sanford | Jay Howell | 461 | 485 | -24 |
| 1991-08-15 | @ SFN | 113 | L 1-4 | 54-59 | 5 | 18,271 | Jose Rijo | Paul McClellan | Paul McClellan | Jose Rijo | Dave Righetti | 462 | 489 | -27 |
| 1991-08-16 | @ SFN | 114 | W 5-0 | 55-59 | 5 | 22,242 | Kip Gross | Buddy Black | Kip Gross | Buddy Black | | 467 | 489 | -22 |
| 1991-08-17 | @ SFN | 115 | W 7-0 | 56-59 | 5 | 34,175 | Scott Scudder | John Burkett | Scott Scudder | John Burkett | | 474 | 489 | -15 |
| 1991-08-18 | @ SFN | 116 | W 4-3 | 57-59 | 4 | 33,220 | Tom Browning | Trevor Wilson | Rob Dibble | Dave Righetti | | 478 | 492 | -14 |
| 1991-08-20 | vs ATL | 117 | W 8-2 | 58-60 | 3 | 0 | Jose Rijo | Steve Avery | Jose Rijo | Steve Avery | | 486 | 494 | -8 |
| 1991-08-20 | vs ATL | 118 | L 1-5 | 58-60 | 3 | 32,910 | Mo Sanford | John Smoltz | John Smoltz | Mo Sanford | | 487 | 499 | -12 |
| 1991-08-21 | vs ATL | 119 | L 9-10 | 58-61 | 3 | 30,005 | Kip Gross | Armando Reynoso | Tony Castillo | Randy Myers | | 496 | 509 | -13 |
| 1991-08-22 | vs ATL | 120 | L 1-4 | 58-62 | 4 | 26,011 | Scott Scudder | Charlie Leibrandt | Charlie Leibrandt | Scott Scudder | Jim Clancy | 497 | 513 | -16 |
| 1991-08-23 | @ NYN | 121 | W 6-1 | 59-62 | 3 | 28,967 | Tom Browning | Frank Viola | Tom Browning | Frank Viola | | 503 | 514 | -11 |
| 1991-08-24 | @ NYN | 122 | W 7-0 | 60-62 | 3 | 39,986 | Jose Rijo | Wally Whitehurst | Jose Rijo | Wally Whitehurst | | 510 | 514 | -4 |
| 1991-08-25 | @ NYN | 123 | L 1-2 | 60-63 | 3 | 26,399 | Randy Myers | David Cone | David Cone | Randy Myers | John Franco | 511 | 516 | -5 |
| 1991-08-26 | vs PHI | 124 | W 5-4 | 61-63 | 3 | 18,683 | Mo Sanford | Jose De Jesus | Kip Gross | Mike Hartley | Rob Dibble | 516 | 520 | -4 |
| 1991-08-27 | vs PHI | 125 | W 4-2 | 62-63 | 3 | 17,787 | Scott Scudder | Bruce Ruffin | Scott Scudder | Bruce Ruffin | Rob Dibble | 520 | 522 | -2 |
| 1991-08-28 | vs MON | 126 | W 11-3 | 63-63 | 3 | 17,264 | Tom Browning | Dennis Martinez | Tom Browning | Dennis Martinez | | 531 | 525 | 6 |
| 1991-08-29 | vs MON | 127 | W 5-4 | 64-63 | 3 | 18,030 | Jose Rijo | Brian Barnes | Jose Rijo | Brian Barnes | Rob Dibble | 536 | 529 | 7 |
| 1991-08-30 | vs NYN | 128 | L 2-3 | 64-64 | 3 | 33,194 | Randy Myers | David Cone | David Cone | Randy Myers | John Franco | 538 | 532 | 6 |
| 1991-08-31 | vs NYN | 129 | L 7-8 | 64-65 | 3 | 39,006 | Mo Sanford | Pete Schourek | John Franco | Rob Dibble | | 545 | 540 | 5 |
| 1991-09-01 | vs NYN | 130 | L 4-9 | 64-66 | 3 | 30,641 | Scott Scudder | Wally Whitehurst | Wally Whitehurst | Scott Scudder | Doug Simons | 549 | 549 | 0 |
| 1991-09-02 | @ PHI | 131 | L 5-8 | 64-67 | 3 | 15,175 | Tom Browning | Terry Mulholland | Terry Mulholland | Tom Browning | Mitch Williams | 554 | 557 | -3 |
| 1991-09-03 | @ PHI | 132 | W 8-5 | 65-67 | 3 | 15,565 | Jose Rijo | Cliff Brantley | Jose Rijo | Cliff Brantley | Rob Dibble | 562 | 562 | 0 |
| 1991-09-04 | @ PHI | 133 | W 5-1 | 66-67 | 3 | 15,962 | Randy Myers | Tommy Greene | Randy Myers | Tommy Greene | | 567 | 563 | 4 |
| 1991-09-06 | @ MON | 134 | L 1-4 | 66-68 | 4 | 9,425 | Scott Scudder | Chris Haney | Chris Haney | Scott Scudder | Mel Rojas | 568 | 567 | 1 |
| 1991-09-07 | @ MON | 135 | L 5-7 | 66-69 | 4 | 9,733 | Tom Browning | Chris Nabholz | Chris Nabholz | Tom Browning | | 573 | 574 | -1 |
| 1991-09-08 | @ MON | 136 | L 2-4 | 66-70 | 4 | 12,272 | Jack Armstrong | Dennis Martinez | Dennis Martinez | Jack Armstrong | Barry Jones | 575 | 578 | -3 |
| 1991-09-09 | vs LAN | 137 | L 4-10 | 66-71 | 4 | 18,389 | Randy Myers | Tim Belcher | Kevin Gross | Milt Hill | | 579 | 588 | -9 |
| 1991-09-10 | vs LAN | 138 | W 6-0 | 67-71 | 4 | 21,256 | Jose Rijo | Ramon Martinez | Jose Rijo | Ramon Martinez | Ted Power | 585 | 588 | -3 |
| 1991-09-11 | vs SFN | 139 | L 2-4 | 67-72 | 4 | 16,279 | Scott Scudder | Bryan Hickerson | Bryan Hickerson | Scott Scudder | Dave Righetti | 587 | 592 | -5 |
| 1991-09-12 | vs SFN | 140 | W 7-3 | 68-72 | 4 | 15,923 | Tom Browning | Paul McClellan | Tom Browning | Paul McClellan | Rob Dibble | 594 | 595 | -1 |
| 1991-09-13 | vs HOU | 141 | W 13-2 | 69-72 | 4 | 22,205 | Jack Armstrong | Ryan Bowen | Jack Armstrong | Ryan Bowen | | 607 | 597 | 10 |
| 1991-09-14 | vs HOU | 142 | L 3-7 | 69-73 | 4 | 25,829 | Randy Myers | Mark Portugal | Xavier Hernandez | Rob Dibble | Curt Schilling | 610 | 604 | 6 |
| 1991-09-15 | vs HOU | 143 | W 10-0 | 70-73 | 4 | 19,585 | Jose Rijo | Chris Gardner | Jose Rijo | Chris Gardner | | 620 | 604 | 16 |
| 1991-09-16 | @ LAN | 144 | L 5-6 | 70-74 | 4 | 30,676 | Scott Scudder | Orel Hershiser | John Wetteland | Ted Power | | 625 | 610 | 15 |
| 1991-09-17 | @ LAN | 145 | L 3-5 | 70-75 | 4 | 33,114 | Tom Browning | Bob Ojeda | Bob Ojeda | Tom Browning | Steve Wilson | 628 | 615 | 13 |
| 1991-09-18 | @ SFN | 146 | L 2-7 | 70-76 | 4 | 9,650 | Jack Armstrong | Trevor Wilson | Trevor Wilson | Jack Armstrong | | 630 | 622 | 8 |
| 1991-09-19 | @ SFN | 147 | L 1-4 | 70-77 | 4 | 9,458 | Randy Myers | Gil Heredia | Francisco Oliveras | Randy Myers | Dave Righetti | 631 | 626 | 5 |
| 1991-09-20 | @ HOU | 148 | L 2-3 | 70-78 | 4 | 7,872 | Jose Rijo | Ryan Bowen | Ryan Bowen | Jose Rijo | Xavier Hernandez | 633 | 629 | 4 |
| 1991-09-21 | @ HOU | 149 | W 4-1 | 71-78 | 4 | 11,144 | Scott Scudder | Jeff Juden | Scott Scudder | Jeff Juden | Rob Dibble | 637 | 630 | 7 |
| 1991-09-22 | @ HOU | 150 | L 1-4 | 71-79 | 4 | 9,076 | Tom Browning | Chris Gardner | Xavier Hernandez | Tom Browning | Mark Portugal | 638 | 634 | 4 |
| 1991-09-25 | @ ATL | 151 | L 1-2 | 72-80 | 4 | 0 | Jack Armstrong | John Smoltz | Alejandro Pena | Ted Power | | 639 | 636 | 3 |
| 1991-09-25 | @ ATL | 152 | W 10-9 | 72-80 | 4 | 38,879 | Randy Myers | Steve Avery | Milt Hill | Mike Stanton | Rob Dibble | 649 | 645 | 4 |
| 1991-09-26 | @ ATL | 153 | W 8-0 | 73-80 | 4 | 42,431 | Jose Rijo | Charlie Leibrandt | Jose Rijo | Charlie Leibrandt | | 657 | 645 | 12 |
| 1991-09-27 | vs SDN | 154 | L 3-8 | 73-81 | 4 | 19,772 | Scott Scudder | Greg Harris | Greg Harris | Scott Scudder | Larry Andersen | 660 | 653 | 7 |
| 1991-09-28 | vs SDN | 155 | L 2-4 | 73-82 | 4 | 21,189 | Tom Browning | Jose Melendez | Jose Melendez | Tom Browning | Mike Maddux | 662 | 657 | 5 |
| 1991-09-29 | vs SDN | 156 | W 8-1 | 74-82 | 4 | 23,387 | Gino Minutelli | Ricky Bones | Ted Power | Ricky Bones | | 670 | 658 | 12 |
| 1991-09-30 | vs ATL | 157 | L 0-4 | 74-83 | 4 | 14,338 | Jack Armstrong | John Smoltz | John Smoltz | Jack Armstrong | | 670 | 662 | 8 |
| 1991-10-01 | vs ATL | 158 | L 6-7 | 74-84 | 4 | 18,105 | Jose Rijo | Charlie Leibrandt | Mike Stanton | Rob Dibble | Alejandro Pena | 676 | 669 | 7 |
| 1991-10-02 | vs ATL | 159 | L 3-6 | 74-85 | 4 | 16,192 | Scott Scudder | Tom Glavine | Tom Glavine | Scott Scudder | Alejandro Pena | 679 | 675 | 4 |
| 1991-10-04 | @ SDN | 160 | L 2-3 | 74-86 | 4 | 40,882 | Tom Browning | Jose Melendez | Jose Melendez | Tom Browning | Jeremy Hernandez | 681 | 678 | 3 |
| 1991-10-05 | @ SDN | 161 | L 7-10 | 74-87 | 5 | 17,847 | Jack Armstrong | Ricky Bones | Mike Maddux | Gino Minutelli | Craig Lefferts | 688 | 688 | 0 |
| 1991-10-06 | @ SDN | 162 | L 1-3 | 74-88 | 5 | 10,256 | Jose Rijo | Andy Benes | Andy Benes | Jose Rijo | Larry Andersen | 689 | 691 | -2 |