| 1991-04-09 | @ OAK | 1 | L 2-7 | 0-1 | 5 | 44,373 | Jack Morris | Dave Stewart | Dave Stewart | Jack Morris | | 2 | 7 | -5 |
| 1991-04-10 | @ OAK | 2 | W 4-1 | 1-1 | 4 | 22,958 | Allan Anderson | Bob Welch | Allan Anderson | Bob Welch | Rick Aguilera | 6 | 8 | -2 |
| 1991-04-11 | @ OAK | 3 | L 0-3 | 1-2 | 5 | 22,169 | Scott Erickson | Joe Slusarski | Joe Slusarski | Scott Erickson | Dennis Eckersley | 6 | 11 | -5 |
| 1991-04-12 | vs CAL | 4 | W 6-0 | 2-2 | 5 | 45,866 | Kevin Tapani | Jim Abbott | Kevin Tapani | Jim Abbott | | 12 | 11 | 1 |
| 1991-04-13 | vs CAL | 5 | L 9-15 | 2-3 | 5 | 32,782 | Mark Guthrie | Scott Lewis | Scott Bailes | Mark Guthrie | | 21 | 26 | -5 |
| 1991-04-14 | vs CAL | 6 | L 4-9 | 2-4 | 5 | 22,513 | Jack Morris | Chuck Finley | Chuck Finley | Jack Morris | | 25 | 35 | -10 |
| 1991-04-15 | @ SEA | 7 | L 4-8 | 2-5 | 5 | 15,120 | Allan Anderson | Randy Johnson | Randy Johnson | Allan Anderson | | 29 | 43 | -14 |
| 1991-04-16 | @ SEA | 8 | L 0-3 | 2-6 | 6 | 8,837 | Scott Erickson | Brian Holman | Brian Holman | Scott Erickson | | 29 | 46 | -17 |
| 1991-04-17 | @ SEA | 9 | L 3-4 | 2-7 | 7 | 9,628 | Kevin Tapani | Scott Bankhead | Michael Jackson | Rick Aguilera | | 32 | 50 | -18 |
| 1991-04-19 | @ CAL | 10 | L 0-2 | 2-8 | 7 | 22,583 | Jack Morris | Chuck Finley | Chuck Finley | Jack Morris | | 32 | 52 | -20 |
| 1991-04-20 | @ CAL | 11 | L 1-2 | 2-9 | 7 | 34,767 | Allan Anderson | Kirk McCaskill | Kirk McCaskill | Allan Anderson | Bryan Harvey | 33 | 54 | -21 |
| 1991-04-21 | @ CAL | 12 | W 4-3 | 3-9 | 7 | 41,337 | Scott Erickson | Mark Langston | Scott Erickson | Mark Eichhorn | Rick Aguilera | 37 | 57 | -20 |
| 1991-04-22 | vs OAK | 13 | W 3-2 | 4-9 | 7 | 12,998 | Kevin Tapani | Mike Moore | Steve Bedrosian | Joe Klink | Rick Aguilera | 40 | 59 | -19 |
| 1991-04-23 | vs OAK | 14 | L 5-7 | 4-10 | 7 | 12,574 | Mark Guthrie | Kirk Dressendorfer | Kirk Dressendorfer | Mark Guthrie | Dennis Eckersley | 45 | 66 | -21 |
| 1991-04-24 | vs OAK | 15 | W 7-4 | 5-10 | 7 | 18,950 | Jack Morris | Dave Stewart | Jack Morris | Dave Stewart | Rick Aguilera | 52 | 70 | -18 |
| 1991-04-25 | vs SEA | 16 | W 4-3 | 6-10 | 7 | 10,230 | Allan Anderson | Erik Hanson | Steve Bedrosian | Michael Jackson | | 56 | 73 | -17 |
| 1991-04-26 | vs SEA | 17 | W 6-0 | 7-10 | 7 | 15,965 | Scott Erickson | Randy Johnson | Scott Erickson | Randy Johnson | | 62 | 73 | -11 |
| 1991-04-27 | vs SEA | 18 | W 7-2 | 8-10 | 6 | 16,247 | Kevin Tapani | Brian Holman | Kevin Tapani | Brian Holman | | 69 | 75 | -6 |
| 1991-04-28 | vs SEA | 19 | W 8-2 | 9-10 | 3 | 18,039 | Jack Morris | Scott Bankhead | Jack Morris | Scott Bankhead | | 77 | 77 | 0 |
| 1991-04-30 | vs BOS | 20 | L 5-7 | 9-11 | 6 | 15,343 | Allan Anderson | Matt Young | Jeff Gray | Steve Bedrosian | Jeff Reardon | 82 | 84 | -2 |
| 1991-05-01 | vs BOS | 21 | W 1-0 | 10-11 | 4 | 14,449 | Scott Erickson | Greg Harris | Scott Erickson | Jeff Gray | | 83 | 84 | -1 |
| 1991-05-02 | @ MIL | 22 | L 1-5 | 10-12 | 5 | 8,902 | Kevin Tapani | Kevin Brown | Kevin Brown | Kevin Tapani | Chuck Crim | 84 | 89 | -5 |
| 1991-05-03 | @ MIL | 23 | L 5-6 | 10-13 | 5 | 13,033 | Jack Morris | Jaime Navarro | Jaime Navarro | Rick Aguilera | Ed Nunez | 89 | 95 | -6 |
| 1991-05-04 | @ MIL | 24 | W 7-4 | 11-13 | 5 | 26,503 | Mark Guthrie | Chris Bosio | Mark Guthrie | Chris Bosio | Steve Bedrosian | 96 | 99 | -3 |
| 1991-05-05 | @ MIL | 25 | W 5-2 | 12-13 | 5 | 11,183 | Allan Anderson | Bill Wegman | Rick Aguilera | Ed Nunez | | 101 | 101 | 0 |
| 1991-05-07 | @ BOS | 26 | W 9-3 | 13-13 | 5 | 23,815 | Scott Erickson | Greg Harris | Scott Erickson | Greg Harris | | 110 | 104 | 6 |
| 1991-05-08 | @ BOS | 27 | L 3-8 | 13-14 | 5 | 25,134 | Jack Morris | Roger Clemens | Roger Clemens | Jack Morris | | 113 | 112 | 1 |
| 1991-05-09 | vs DET | 28 | L 0-3 | 13-15 | 6 | 10,765 | Kevin Tapani | Dan Petry | Dan Petry | Kevin Tapani | Paul Gibson | 113 | 115 | -2 |
| 1991-05-10 | vs DET | 29 | W 5-2 | 14-15 | 5 | 16,012 | Mark Guthrie | Walt Terrell | Mark Guthrie | Walt Terrell | Rick Aguilera | 118 | 117 | 1 |
| 1991-05-11 | vs DET | 30 | W 5-4 | 15-15 | 5 | 23,063 | Allan Anderson | Steve Searcy | Carl Willis | Mike Henneman | Rick Aguilera | 123 | 121 | 2 |
| 1991-05-12 | vs DET | 31 | W 8-3 | 16-15 | 4 | 13,189 | Scott Erickson | Bill Gullickson | Scott Erickson | Bill Gullickson | | 131 | 124 | 7 |
| 1991-05-14 | vs MIL | 32 | W 5-1 | 17-15 | 3 | 13,395 | Jack Morris | Jaime Navarro | Jack Morris | Jaime Navarro | | 136 | 125 | 11 |
| 1991-05-15 | vs MIL | 33 | L 2-4 | 17-16 | 4 | 15,992 | Kevin Tapani | Chris Bosio | Chris Bosio | Kevin Tapani | Dan Plesac | 138 | 129 | 9 |
| 1991-05-16 | vs MIL | 34 | L 3-6 | 17-17 | 6 | 15,182 | Allan Anderson | Bill Wegman | Bill Wegman | Allan Anderson | Darren Holmes | 141 | 135 | 6 |
| 1991-05-17 | @ DET | 35 | W 8-1 | 18-17 | 5 | 13,673 | Scott Erickson | Bill Gullickson | Scott Erickson | Bill Gullickson | Steve Bedrosian | 149 | 136 | 13 |
| 1991-05-18 | @ DET | 36 | W 4-1 | 19-17 | 4 | 31,432 | Mark Guthrie | Frank Tanana | Mark Guthrie | Frank Tanana | Rick Aguilera | 153 | 137 | 16 |
| 1991-05-19 | @ DET | 37 | L 3-8 | 19-18 | 6 | 17,148 | Jack Morris | Dan Petry | Dan Petry | Jack Morris | | 156 | 145 | 11 |
| 1991-05-21 | vs TEX | 38 | L 5-6 | 19-19 | 5 | 12,427 | Kevin Tapani | Bobby Witt | Bobby Witt | Kevin Tapani | Jeff Russell | 161 | 151 | 10 |
| 1991-05-22 | vs TEX | 39 | L 2-5 | 19-20 | 6 | 13,283 | Allan Anderson | Kevin Brown | Gerald Alexander | Carl Willis | Jeff Russell | 163 | 156 | 7 |
| 1991-05-23 | vs TEX | 40 | L 6-10 | 19-21 | 6 | 16,036 | Scott Erickson | Jose Guzman | Jeff Russell | Steve Bedrosian | | 169 | 166 | 3 |
| 1991-05-24 | vs KCA | 41 | W 3-2 | 20-21 | 6 | 16,394 | Jack Morris | Storm Davis | Jack Morris | Storm Davis | Rick Aguilera | 172 | 168 | 4 |
| 1991-05-25 | vs KCA | 42 | L 2-11 | 20-22 | 6 | 19,943 | Mark Guthrie | Mark Gubicza | Mark Gubicza | Mark Guthrie | | 174 | 179 | -5 |
| 1991-05-26 | vs KCA | 43 | L 1-5 | 20-23 | 6 | 21,941 | Kevin Tapani | Bret Saberhagen | Bret Saberhagen | Kevin Tapani | | 175 | 184 | -9 |
| 1991-05-27 | @ TEX | 44 | L 4-11 | 20-24 | 6 | 31,302 | Allan Anderson | Kevin Brown | Kevin Brown | Allan Anderson | | 179 | 195 | -16 |
| 1991-05-28 | @ TEX | 45 | W 3-0 | 21-24 | 6 | 26,518 | Scott Erickson | Jose Guzman | Scott Erickson | Jose Guzman | Rick Aguilera | 182 | 195 | -13 |
| 1991-05-29 | @ TEX | 46 | W 9-1 | 22-24 | 5 | 31,340 | Jack Morris | Nolan Ryan | Jack Morris | Nolan Ryan | | 191 | 196 | -5 |
| 1991-05-30 | @ KCA | 47 | W 4-2 | 23-24 | 5 | 31,940 | Mark Guthrie | Mark Gubicza | Mark Guthrie | Mark Gubicza | Rick Aguilera | 195 | 198 | -3 |
| 1991-05-31 | @ KCA | 48 | L 1-4 | 23-25 | 5 | 26,321 | Kevin Tapani | Bret Saberhagen | Bret Saberhagen | Kevin Tapani | | 196 | 202 | -6 |
| 1991-06-01 | @ KCA | 49 | W 8-4 | 24-25 | 5 | 29,985 | Allan Anderson | Kevin Appier | Allan Anderson | Kevin Appier | | 204 | 206 | -2 |
| 1991-06-02 | @ KCA | 50 | W 4-1 | 25-25 | 5 | 25,394 | Scott Erickson | Tom Gordon | Scott Erickson | Tom Gordon | Rick Aguilera | 208 | 207 | 1 |
| 1991-06-03 | vs BAL | 51 | W 3-2 | 26-25 | 5 | 12,497 | Jack Morris | Jeff Robinson | Jack Morris | Jeff Robinson | Rick Aguilera | 211 | 209 | 2 |
| 1991-06-04 | vs BAL | 52 | W 4-3 | 27-25 | 5 | 11,672 | Mark Guthrie | Jeff Ballard | Carl Willis | Gregg Olson | | 215 | 212 | 3 |
| 1991-06-05 | vs BAL | 53 | W 4-3 | 28-25 | 5 | 12,464 | Kevin Tapani | Jose Mesa | Kevin Tapani | Jose Mesa | Rick Aguilera | 219 | 215 | 4 |
| 1991-06-07 | vs CLE | 54 | W 2-0 | 29-25 | 4 | 18,200 | Allan Anderson | Tom Candiotti | Allan Anderson | Tom Candiotti | Rick Aguilera | 221 | 215 | 6 |
| 1991-06-08 | vs CLE | 55 | W 2-1 | 30-25 | 3 | 25,313 | Scott Erickson | Charles Nagy | Scott Erickson | Charles Nagy | Rick Aguilera | 223 | 216 | 7 |
| 1991-06-09 | vs CLE | 56 | W 9-2 | 31-25 | 3 | 20,677 | Jack Morris | Rod Nichols | Jack Morris | Rod Nichols | | 232 | 218 | 14 |
| 1991-06-10 | vs CLE | 57 | W 8-5 | 32-25 | 3 | 14,171 | Mark Guthrie | Eric King | Paul Abbott | Eric King | Rick Aguilera | 240 | 223 | 17 |
| 1991-06-11 | vs NYA | 58 | W 5-3 | 33-25 | 3 | 18,233 | Kevin Tapani | Scott Sanderson | Kevin Tapani | John Habyan | Rick Aguilera | 245 | 226 | 19 |
| 1991-06-12 | vs NYA | 59 | W 6-3 | 34-25 | 2 | 19,178 | Allan Anderson | Jeff Johnson | Allan Anderson | Jeff Johnson | Steve Bedrosian | 251 | 229 | 22 |
| 1991-06-13 | vs NYA | 60 | W 10-3 | 35-25 | 2 | 29,867 | Scott Erickson | Mike Witt | Scott Erickson | Mike Witt | | 261 | 232 | 29 |
| 1991-06-14 | @ CLE | 61 | W 7-0 | 36-25 | 2 | 55,158 | Jack Morris | Jeff Shaw | Jack Morris | Jeff Shaw | | 268 | 232 | 36 |
| 1991-06-15 | @ CLE | 62 | W 11-7 | 37-25 | 2 | 20,997 | Mark Guthrie | Jeff Mutis | Paul Abbott | Jeff Mutis | | 279 | 239 | 40 |
| 1991-06-16 | @ CLE | 63 | W 4-2 | 38-25 | 1 | 20,725 | Kevin Tapani | Greg Swindell | Rick Aguilera | Shawn Hillegas | | 283 | 241 | 42 |
| 1991-06-17 | @ BAL | 64 | L 5-6 | 38-26 | 1 | 25,600 | Allan Anderson | Bob Milacki | Mark Williamson | Rick Aguilera | | 288 | 247 | 41 |
| 1991-06-18 | @ BAL | 65 | W 9-2 | 39-26 | 1 | 26,401 | Scott Erickson | Roy Smith | Scott Erickson | Roy Smith | Carl Willis | 297 | 249 | 48 |
| 1991-06-19 | @ BAL | 66 | W 8-4 | 40-26 | 1 | 44,742 | Jack Morris | Jeff Robinson | Jack Morris | Gregg Olson | | 305 | 253 | 52 |
| 1991-06-21 | @ NYA | 67 | W 5-4 | 41-26 | 1 | 32,209 | Mark Guthrie | Scott Sanderson | Mark Guthrie | Scott Sanderson | Rick Aguilera | 310 | 257 | 53 |
| 1991-06-22 | @ NYA | 68 | W 4-3 | 42-26 | 1 | 25,352 | Kevin Tapani | Wade Taylor | Kevin Tapani | Wade Taylor | Rick Aguilera | 314 | 260 | 54 |
| 1991-06-23 | @ NYA | 69 | L 2-11 | 42-27 | 1 | 36,952 | Allan Anderson | Scott Kamieniecki | Scott Kamieniecki | Allan Anderson | | 316 | 271 | 45 |
| 1991-06-24 | @ NYA | 70 | W 5-0 | 43-27 | 1 | 23,142 | Scott Erickson | Jeff Johnson | Scott Erickson | Jeff Johnson | | 321 | 271 | 50 |
| 1991-06-25 | vs TOR | 71 | W 8-6 | 44-27 | 1 | 26,350 | Jack Morris | Todd Stottlemyre | Jack Morris | Todd Stottlemyre | Rick Aguilera | 329 | 277 | 52 |
| 1991-06-26 | vs TOR | 72 | L 2-5 | 44-28 | 1 | 25,503 | Mark Guthrie | David Wells | David Wells | Mark Guthrie | Tom Henke | 331 | 282 | 49 |
| 1991-06-27 | vs TOR | 73 | L 0-1 | 44-29 | 1 | 35,598 | Kevin Tapani | Juan Guzman | Juan Guzman | Kevin Tapani | Tom Henke | 331 | 283 | 48 |
| 1991-06-28 | vs CHA | 74 | L 2-4 | 44-30 | 1 | 37,865 | Allan Anderson | Charlie Hough | Charlie Hough | Allan Anderson | Bobby Thigpen | 333 | 287 | 46 |
| 1991-06-29 | vs CHA | 75 | L 4-8 | 44-31 | 1 | 50,525 | Scott Erickson | Greg Hibbard | Greg Hibbard | Scott Erickson | | 337 | 295 | 42 |
| 1991-06-30 | vs CHA | 76 | W 3-0 | 45-31 | 1 | 51,085 | Jack Morris | Jack McDowell | Jack Morris | Jack McDowell | | 340 | 295 | 45 |
| 1991-07-01 | vs CHA | 77 | L 4-5 | 45-32 | 1 | 26,427 | Paul Abbott | Ramon Garcia | Bobby Thigpen | Carl Willis | | 344 | 300 | 44 |
| 1991-07-02 | @ TOR | 78 | L 3-4 | 45-33 | 1 | 48,676 | Kevin Tapani | Juan Guzman | Duane Ward | Terry Leach | | 347 | 304 | 43 |
| 1991-07-03 | @ TOR | 79 | L 0-4 | 45-34 | 2 | 50,071 | Allan Anderson | Tom Candiotti | Tom Candiotti | Allan Anderson | | 347 | 308 | 39 |
| 1991-07-04 | @ TOR | 80 | W 1-0 | 46-34 | 1 | 50,293 | David West | Jimmy Key | David West | Jimmy Key | Rick Aguilera | 348 | 308 | 40 |
| 1991-07-05 | @ CHA | 81 | L 2-4 | 46-35 | 1 | 41,657 | Jack Morris | Jack McDowell | Jack McDowell | Jack Morris | Bobby Thigpen | 350 | 312 | 38 |
| 1991-07-06 | @ CHA | 82 | W 5-4 | 47-35 | 1 | 41,606 | Paul Abbott | Ramon Garcia | Carl Willis | Scott Radinsky | Rick Aguilera | 355 | 316 | 39 |
| 1991-07-07 | @ CHA | 83 | L 3-4 | 47-36 | 2 | 41,900 | Kevin Tapani | Alex Fernandez | Ken Patterson | Mark Guthrie | Bobby Thigpen | 358 | 320 | 38 |
| 1991-07-11 | vs BOS | 84 | W 7-3 | 48-36 | 1 | 31,409 | Kevin Tapani | Greg Harris | Carl Willis | Greg Harris | | 365 | 323 | 42 |
| 1991-07-12 | vs BOS | 85 | W 5-4 | 49-36 | 1 | 37,262 | Allan Anderson | Roger Clemens | Paul Abbott | Roger Clemens | Rick Aguilera | 370 | 327 | 43 |
| 1991-07-13 | vs BOS | 86 | W 3-1 | 50-36 | 1 | 42,803 | Jack Morris | Kevin Morton | Jack Morris | Kevin Morton | Rick Aguilera | 373 | 328 | 45 |
| 1991-07-14 | vs BOS | 87 | L 3-5 | 50-37 | 1 | 38,066 | David West | Joe Hesketh | Joe Hesketh | David West | Jeff Reardon | 376 | 333 | 43 |
| 1991-07-15 | @ MIL | 88 | W 11-7 | 51-37 | 1 | 16,201 | Scott Erickson | Jim Hunter | Mark Guthrie | Jim Hunter | Steve Bedrosian | 387 | 340 | 47 |
| 1991-07-16 | @ MIL | 89 | L 3-4 | 51-38 | 1 | 15,954 | Kevin Tapani | Chris Bosio | Doug Henry | Rick Aguilera | | 390 | 344 | 46 |
| 1991-07-18 | @ BOS | 90 | W 11-3 | 52-38 | 1 | 34,630 | Jack Morris | Kevin Morton | Jack Morris | Kevin Morton | | 401 | 347 | 54 |
| 1991-07-19 | @ BOS | 91 | W 3-2 | 53-38 | 1 | 33,758 | David West | Joe Hesketh | Steve Bedrosian | Greg Harris | Rick Aguilera | 404 | 349 | 55 |
| 1991-07-20 | @ BOS | 92 | W 5-0 | 54-38 | 1 | 33,005 | Scott Erickson | Mike Gardiner | Scott Erickson | Mike Gardiner | Mark Guthrie | 409 | 349 | 60 |
| 1991-07-21 | @ BOS | 93 | W 14-1 | 55-38 | 1 | 32,849 | Kevin Tapani | Tom Bolton | Kevin Tapani | Tom Bolton | | 423 | 350 | 73 |
| 1991-07-23 | @ DET | 94 | L 3-6 | 55-39 | 1 | 21,976 | Jack Morris | Frank Tanana | Frank Tanana | Allan Anderson | Mike Henneman | 426 | 356 | 70 |
| 1991-07-24 | @ DET | 95 | L 3-6 | 55-40 | 1 | 18,391 | David West | Bill Gullickson | Bill Gullickson | David West | Mike Henneman | 429 | 362 | 67 |
| 1991-07-25 | @ DET | 96 | W 9-3 | 56-40 | 1 | 20,007 | Scott Erickson | Scott Aldred | Scott Erickson | Scott Aldred | Steve Bedrosian | 438 | 365 | 73 |
| 1991-07-26 | vs MIL | 97 | W 6-3 | 57-40 | 1 | 39,211 | Kevin Tapani | Chris Bosio | Kevin Tapani | Darren Holmes | Rick Aguilera | 444 | 368 | 76 |
| 1991-07-27 | vs MIL | 98 | W 7-4 | 58-40 | 1 | 47,632 | Denny Neagle | Bill Wegman | Carl Willis | Bill Wegman | | 451 | 372 | 79 |
| 1991-07-28 | vs MIL | 99 | L 2-11 | 58-41 | 1 | 47,524 | Jack Morris | Jaime Navarro | Jaime Navarro | Jack Morris | | 453 | 383 | 70 |
| 1991-07-29 | vs DET | 100 | W 6-3 | 59-41 | 1 | 35,599 | David West | Bill Gullickson | David West | Bill Gullickson | Rick Aguilera | 459 | 386 | 73 |
| 1991-07-30 | vs DET | 101 | W 9-7 | 60-41 | 1 | 42,035 | Scott Erickson | Scott Aldred | Carl Willis | John Cerutti | | 468 | 393 | 75 |
| 1991-07-31 | @ NYA | 102 | W 12-3 | 61-41 | 1 | 24,300 | Kevin Tapani | Scott Sanderson | Kevin Tapani | Scott Sanderson | | 480 | 396 | 84 |
| 1991-08-01 | @ NYA | 103 | L 3-8 | 61-42 | 1 | 25,711 | Paul Abbott | Greg Cadaret | Greg Cadaret | Paul Abbott | | 483 | 404 | 79 |
| 1991-08-02 | @ OAK | 104 | L 1-3 | 61-43 | 1 | 44,160 | Jack Morris | Bob Welch | Bob Welch | Jack Morris | | 484 | 407 | 77 |
| 1991-08-03 | @ OAK | 105 | W 8-6 | 62-43 | 1 | 43,119 | David West | Joe Slusarski | Steve Bedrosian | Joe Klink | Rick Aguilera | 492 | 413 | 79 |
| 1991-08-04 | @ OAK | 106 | W 6-2 | 63-43 | 1 | 44,088 | Scott Erickson | Dave Stewart | Scott Erickson | Dave Stewart | Carl Willis | 498 | 415 | 83 |
| 1991-08-05 | @ CAL | 107 | W 7-4 | 64-43 | 1 | 25,439 | Kevin Tapani | Joe Grahe | Kevin Tapani | Joe Grahe | Rick Aguilera | 505 | 419 | 86 |
| 1991-08-06 | @ CAL | 108 | W 7-4 | 65-43 | 1 | 27,872 | Willie Banks | Chuck Finley | Willie Banks | Chuck Finley | | 512 | 423 | 89 |
| 1991-08-07 | @ CAL | 109 | L 1-8 | 65-44 | 1 | 30,726 | Jack Morris | Jim Abbott | Jim Abbott | Jack Morris | | 513 | 431 | 82 |
| 1991-08-09 | @ SEA | 110 | W 5-2 | 66-44 | 1 | 31,112 | David West | Randy Johnson | David West | Randy Johnson | Rick Aguilera | 518 | 433 | 85 |
| 1991-08-10 | @ SEA | 111 | L 0-8 | 66-45 | 1 | 29,548 | Scott Erickson | Erik Hanson | Erik Hanson | Scott Erickson | | 518 | 441 | 77 |
| 1991-08-11 | @ SEA | 112 | W 5-2 | 67-45 | 1 | 31,007 | Kevin Tapani | Bill Krueger | Kevin Tapani | Bill Krueger | | 523 | 443 | 80 |
| 1991-08-12 | vs CAL | 113 | W 4-3 | 68-45 | 1 | 31,789 | Jack Morris | Chuck Finley | Jack Morris | Chris Beasley | Rick Aguilera | 527 | 446 | 81 |
| 1991-08-13 | vs CAL | 114 | L 3-8 | 68-46 | 1 | 41,354 | Willie Banks | Jim Abbott | Jim Abbott | Willie Banks | Bryan Harvey | 530 | 454 | 76 |
| 1991-08-14 | vs CAL | 115 | L 4-7 | 68-47 | 1 | 26,242 | David West | Kirk McCaskill | Kirk McCaskill | David West | Bryan Harvey | 534 | 461 | 73 |
| 1991-08-15 | vs CAL | 116 | L 1-9 | 68-48 | 1 | 31,880 | Scott Erickson | Mark Langston | Mark Langston | Scott Erickson | | 535 | 470 | 65 |
| 1991-08-16 | vs OAK | 117 | W 5-4 | 69-48 | 1 | 50,019 | Kevin Tapani | Mike Moore | Rick Aguilera | Gene Nelson | | 540 | 474 | 66 |
| 1991-08-17 | vs OAK | 118 | W 12-4 | 70-48 | 1 | 52,080 | Jack Morris | Bob Welch | Jack Morris | Bob Welch | | 552 | 478 | 74 |
| 1991-08-18 | vs OAK | 119 | W 6-4 | 71-48 | 1 | 44,295 | Willie Banks | Dave Stewart | Carl Willis | Rick Honeycutt | Rick Aguilera | 558 | 482 | 76 |
| 1991-08-19 | vs OAK | 120 | L 7-8 | 71-49 | 1 | 45,544 | David West | Joe Slusarski | Joe Klink | Steve Bedrosian | Dennis Eckersley | 565 | 490 | 75 |
| 1991-08-20 | vs SEA | 121 | W 10-5 | 72-49 | 1 | 32,090 | Scott Erickson | Erik Hanson | Scott Erickson | Erik Hanson | Mark Guthrie | 575 | 495 | 80 |
| 1991-08-21 | vs SEA | 122 | W 9-1 | 73-49 | 1 | 30,631 | Kevin Tapani | Bill Krueger | Kevin Tapani | Bill Krueger | | 584 | 496 | 88 |
| 1991-08-22 | vs SEA | 123 | W 5-4 | 74-49 | 1 | 35,874 | Jack Morris | Rich DeLucia | Rick Aguilera | Mike Schooler | | 589 | 500 | 89 |
| 1991-08-23 | @ BAL | 124 | L 4-5 | 74-50 | 1 | 35,365 | Allan Anderson | Ben McDonald | Gregg Olson | Carl Willis | | 593 | 505 | 88 |
| 1991-08-24 | @ BAL | 125 | W 5-2 | 75-50 | 1 | 37,958 | Tom Edens | Bob Milacki | Steve Bedrosian | Mike Flanagan | Rick Aguilera | 598 | 507 | 91 |
| 1991-08-25 | @ BAL | 126 | L 3-7 | 75-51 | 1 | 36,202 | Scott Erickson | Mike Mussina | Mike Mussina | Scott Erickson | Todd Frohwirth | 601 | 514 | 87 |
| 1991-08-26 | @ CLE | 127 | W 5-3 | 76-51 | 1 | 5,003 | Kevin Tapani | Dave Otto | Kevin Tapani | Dave Otto | Rick Aguilera | 606 | 517 | 89 |
| 1991-08-27 | @ CLE | 128 | L 1-2 | 76-52 | 1 | 7,664 | Jack Morris | Greg Swindell | Greg Swindell | Jack Morris | Steve Olin | 607 | 519 | 88 |
| 1991-08-28 | @ CLE | 129 | W 4-2 | 77-52 | 1 | 5,317 | David West | Eric King | David West | Eric King | Rick Aguilera | 611 | 521 | 90 |
| 1991-08-30 | vs BAL | 130 | L 5-11 | 77-53 | 1 | 30,214 | Tom Edens | Bob Milacki | Bob Milacki | Tom Edens | | 616 | 532 | 84 |
| 1991-08-31 | vs BAL | 131 | W 5-2 | 78-53 | 1 | 38,395 | Kevin Tapani | Mike Mussina | Kevin Tapani | Mike Mussina | Rick Aguilera | 621 | 534 | 87 |
| 1991-09-01 | vs BAL | 132 | W 14-3 | 79-53 | 1 | 31,435 | Jack Morris | Arthur Rhodes | Jack Morris | Arthur Rhodes | | 635 | 537 | 98 |
| 1991-09-02 | vs CLE | 133 | W 9-3 | 80-53 | 1 | 28,267 | Scott Erickson | Eric King | Scott Erickson | Eric King | Rick Aguilera | 644 | 540 | 104 |
| 1991-09-04 | vs CLE | 134 | L 4-8 | 80-54 | 1 | 19,760 | David West | Willie Blair | Willie Blair | David West | Shawn Hillegas | 648 | 548 | 100 |
| 1991-09-06 | vs NYA | 135 | W 3-1 | 81-54 | 1 | 27,804 | Kevin Tapani | Wade Taylor | Kevin Tapani | Wade Taylor | Rick Aguilera | 651 | 549 | 102 |
| 1991-09-07 | vs NYA | 136 | W 3-2 | 82-54 | 1 | 35,504 | Jack Morris | Pascual Perez | Carl Willis | Lee Guetterman | | 654 | 551 | 103 |
| 1991-09-08 | vs NYA | 137 | W 6-5 | 83-54 | 1 | 27,281 | Scott Erickson | Jeff Johnson | Scott Erickson | Jeff Johnson | Steve Bedrosian | 660 | 556 | 104 |
| 1991-09-09 | @ KCA | 138 | W 10-4 | 84-54 | 1 | 22,189 | Tom Edens | Mike Boddicker | Tom Edens | Mike Boddicker | Gary Wayne | 670 | 560 | 110 |
| 1991-09-10 | @ KCA | 139 | W 7-2 | 85-54 | 1 | 19,923 | Allan Anderson | Mark Gubicza | Allan Anderson | Mark Gubicza | Rick Aguilera | 677 | 562 | 115 |
| 1991-09-11 | @ KCA | 140 | L 1-4 | 85-55 | 1 | 18,290 | Kevin Tapani | Mark Davis | Mark Davis | Kevin Tapani | Jeff Montgomery | 678 | 566 | 112 |
| 1991-09-12 | @ TEX | 141 | L 3-4 | 85-56 | 1 | 17,974 | Jack Morris | Nolan Ryan | Nolan Ryan | Jack Morris | Jeff Russell | 681 | 570 | 111 |
| 1991-09-13 | @ TEX | 142 | W 7-3 | 86-56 | 1 | 24,386 | Scott Erickson | Kevin Brown | Terry Leach | Kenny Rogers | | 688 | 573 | 115 |
| 1991-09-14 | @ TEX | 143 | L 0-3 | 86-57 | 1 | 40,718 | Tom Edens | Oil Can Boyd | Oil Can Boyd | Tom Edens | Kenny Rogers | 688 | 576 | 112 |
| 1991-09-15 | @ TEX | 144 | L 2-4 | 86-58 | 1 | 19,775 | Allan Anderson | Jose Guzman | Jose Guzman | Allan Anderson | Jeff Russell | 690 | 580 | 110 |
| 1991-09-16 | vs KCA | 145 | W 9-0 | 87-58 | 1 | 18,745 | Kevin Tapani | Mark Gubicza | Kevin Tapani | Mark Gubicza | | 699 | 580 | 119 |
| 1991-09-17 | vs KCA | 146 | L 1-4 | 87-59 | 1 | 22,067 | Jack Morris | Bret Saberhagen | Bret Saberhagen | Jack Morris | Jeff Montgomery | 700 | 584 | 116 |
| 1991-09-18 | vs KCA | 147 | L 4-10 | 87-60 | 1 | 21,726 | Scott Erickson | Luis Aquino | Luis Aquino | Scott Erickson | | 704 | 594 | 110 |
| 1991-09-20 | vs TEX | 148 | W 6-4 | 88-60 | 1 | 29,503 | Denny Neagle | Oil Can Boyd | Gary Wayne | Wayne Rosenthal | Rick Aguilera | 710 | 598 | 112 |
| 1991-09-21 | vs TEX | 149 | W 8-4 | 89-60 | 1 | 43,138 | Kevin Tapani | Jose Guzman | Kevin Tapani | Jose Guzman | | 718 | 602 | 116 |
| 1991-09-22 | vs TEX | 150 | W 9-4 | 90-60 | 1 | 44,539 | Jack Morris | Hector Fajardo | Jack Morris | Hector Fajardo | | 727 | 606 | 121 |
| 1991-09-24 | vs CHA | 151 | W 9-2 | 91-60 | 1 | 45,496 | Scott Erickson | Jack McDowell | Scott Erickson | Jack McDowell | | 736 | 608 | 128 |
| 1991-09-25 | vs CHA | 152 | L 1-6 | 91-61 | 1 | 43,450 | Allan Anderson | Alex Fernandez | Alex Fernandez | Allan Anderson | | 737 | 614 | 123 |
| 1991-09-27 | @ TOR | 153 | L 2-7 | 91-62 | 1 | 50,326 | Kevin Tapani | Juan Guzman | Juan Guzman | Kevin Tapani | | 739 | 621 | 118 |
| 1991-09-28 | @ TOR | 154 | W 5-0 | 92-62 | 1 | 50,319 | Jack Morris | Tom Candiotti | Jack Morris | Tom Candiotti | | 744 | 621 | 123 |
| 1991-09-29 | @ TOR | 155 | L 1-2 | 92-63 | 1 | 50,315 | Scott Erickson | Todd Stottlemyre | Todd Stottlemyre | Scott Erickson | Duane Ward | 745 | 623 | 122 |
| 1991-09-30 | @ CHA | 156 | W 8-3 | 93-63 | 1 | 37,740 | Tom Edens | Alex Fernandez | Tom Edens | Alex Fernandez | | 753 | 626 | 127 |
| 1991-10-01 | @ CHA | 157 | W 3-2 | 94-63 | 1 | 32,181 | David West | Wilson Alvarez | Mark Guthrie | Melido Perez | Rick Aguilera | 756 | 628 | 128 |
| 1991-10-03 | @ CHA | 158 | L 2-3 | 94-65 | 1 | 30,000 | Jack Morris | Jack McDowell | Scott Radinsky | Rick Aguilera | | 758 | 631 | 127 |
| 1991-10-03 | @ CHA | 159 | L 12-13 | 94-65 | 1 | 31,022 | Kevin Tapani | Greg Hibbard | Brian Drahman | Terry Leach | | 770 | 644 | 126 |
| 1991-10-04 | vs TOR | 160 | L 1-4 | 94-66 | 1 | 35,124 | Denny Neagle | Todd Stottlemyre | Todd Stottlemyre | Denny Neagle | Duane Ward | 771 | 648 | 123 |
| 1991-10-05 | vs TOR | 161 | W 3-1 | 95-66 | 1 | 51,058 | Scott Erickson | Juan Guzman | Scott Erickson | Juan Guzman | Rick Aguilera | 774 | 649 | 125 |
| 1991-10-06 | vs TOR | 162 | L 2-3 | 95-67 | 1 | 37,794 | Tom Edens | Pat Hentgen | David Weathers | Allan Anderson | Duane Ward | 776 | 652 | 124 |