| 1990-04-12 | @ NYA | 1 | L 4-6 | 0-1 | 6 | 50,114 | Buddy Black | Dave LaPoint | Eric Plunk | Jesse Orosco | | 4 | 6 | -2 |
| 1990-04-13 | @ CHA | 2 | W 6-2 | 1-1 | 4 | 11,374 | John Farrell | Jack McDowell | John Farrell | Bill Long | Doug Jones | 10 | 8 | 2 |
| 1990-04-14 | @ CHA | 3 | L 4-9 | 1-2 | 5 | 12,125 | Greg Swindell | Melido Perez | Melido Perez | Greg Swindell | | 14 | 17 | -3 |
| 1990-04-15 | @ CHA | 4 | L 1-4 | 1-3 | 6 | 9,320 | Kevin Bearse | Greg Hibbard | Greg Hibbard | Kevin Bearse | Bobby Thigpen | 15 | 21 | -6 |
| 1990-04-16 | @ KCA | 5 | W 6-3 | 2-3 | 5 | 20,166 | Tom Candiotti | Mark Gubicza | Tom Candiotti | Mark Gubicza | Doug Jones | 21 | 24 | -3 |
| 1990-04-17 | @ KCA | 6 | L 2-4 | 2-4 | 5 | 17,616 | Buddy Black | Richard Dotson | Steve Farr | Steve Olin | Mark Davis | 23 | 28 | -5 |
| 1990-04-18 | @ KCA | 7 | L 0-7 | 2-5 | 7 | 19,752 | John Farrell | Storm Davis | Storm Davis | John Farrell | | 23 | 35 | -12 |
| 1990-04-19 | vs NYA | 8 | W 1-0 | 3-5 | 7 | 6,000 | Greg Swindell | Pascual Perez | Greg Swindell | Pascual Perez | Doug Jones | 24 | 35 | -11 |
| 1990-04-21 | vs CHA | 9 | W 8-4 | 4-5 | 5 | 9,076 | Tom Candiotti | Melido Perez | Tom Candiotti | Melido Perez | | 32 | 39 | -7 |
| 1990-04-22 | vs CHA | 10 | W 5-2 | 5-5 | 5 | 16,400 | Buddy Black | Greg Hibbard | Buddy Black | Greg Hibbard | Doug Jones | 37 | 41 | -4 |
| 1990-04-23 | @ TOR | 11 | L 9-12 | 5-6 | 5 | 34,139 | John Farrell | Mike Flanagan | Frank Wills | Kevin Wickander | Duane Ward | 46 | 53 | -7 |
| 1990-04-24 | @ TOR | 12 | L 3-4 | 5-7 | 6 | 35,203 | Greg Swindell | Jimmy Key | Jimmy Key | Greg Swindell | David Wells | 49 | 57 | -8 |
| 1990-04-25 | @ TOR | 13 | L 3-5 | 5-8 | 7 | 38,168 | Kevin Bearse | Todd Stottlemyre | Todd Stottlemyre | Rod Nichols | Duane Ward | 52 | 62 | -10 |
| 1990-04-26 | @ TOR | 14 | W 4-3 | 6-8 | 6 | 44,174 | Tom Candiotti | Dave Stieb | Tom Candiotti | Dave Stieb | Doug Jones | 56 | 65 | -9 |
| 1990-04-27 | vs MIN | 15 | W 7-2 | 7-8 | 4 | 12,753 | Buddy Black | David West | Buddy Black | David West | | 63 | 67 | -4 |
| 1990-04-28 | vs MIN | 16 | W 3-0 | 8-8 | 4 | 9,978 | John Farrell | Allan Anderson | John Farrell | Allan Anderson | Jesse Orosco | 66 | 67 | -1 |
| 1990-04-29 | vs MIN | 17 | W 6-4 | 9-8 | 4 | 14,956 | Greg Swindell | Roy Smith | Greg Swindell | Roy Smith | Doug Jones | 72 | 71 | 1 |
| 1990-04-30 | vs TOR | 18 | L 4-10 | 9-9 | 4 | 6,254 | Kevin Bearse | Todd Stottlemyre | Todd Stottlemyre | Kevin Bearse | | 76 | 81 | -5 |
| 1990-05-01 | vs TOR | 19 | L 3-4 | 9-10 | 4 | 5,111 | Tom Candiotti | Dave Stieb | Dave Stieb | Tom Candiotti | Tom Henke | 79 | 85 | -6 |
| 1990-05-02 | vs TOR | 20 | W 3-0 | 10-10 | 4 | 8,801 | Buddy Black | John Cerutti | Buddy Black | John Cerutti | Doug Jones | 82 | 85 | -3 |
| 1990-05-03 | @ NYA | 21 | W 10-5 | 11-10 | 4 | 15,169 | John Farrell | Greg Cadaret | Jesse Orosco | Jeff Robinson | Doug Jones | 92 | 90 | 2 |
| 1990-05-05 | vs TEX | 22 | L 5-9 | 11-11 | 4 | 6,324 | Greg Swindell | Kevin Brown | Kevin Brown | Cecilio Guante | | 97 | 99 | -2 |
| 1990-05-06 | vs TEX | 23 | W 9-5 | 13-11 | 4 | 0 | Tom Candiotti | Brian Bohanon | Tom Candiotti | Brian Bohanon | Jesse Orosco | 106 | 104 | 2 |
| 1990-05-06 | vs TEX | 24 | W 3-0 | 13-11 | 4 | 24,730 | Jeff Shaw | Bobby Witt | Jeff Shaw | Bobby Witt | Doug Jones | 109 | 104 | 5 |
| 1990-05-07 | vs KCA | 25 | L 2-4 | 13-12 | 4 | 7,193 | Buddy Black | Kevin Appier | Jeff Montgomery | Cecilio Guante | Mark Davis | 111 | 108 | 3 |
| 1990-05-08 | @ MIN | 26 | L 5-6 | 13-13 | 4 | 13,608 | John Farrell | David West | Juan Berenguer | Steve Olin | Rick Aguilera | 116 | 114 | 2 |
| 1990-05-09 | @ MIN | 27 | W 7-3 | 14-13 | 4 | 16,748 | Sergio Valdez | John Candelaria | Sergio Valdez | John Candelaria | Doug Jones | 123 | 117 | 6 |
| 1990-05-10 | @ MIN | 28 | L 2-3 | 14-14 | 4 | 13,439 | Greg Swindell | Roy Smith | Roy Smith | Greg Swindell | Rick Aguilera | 125 | 120 | 5 |
| 1990-05-11 | @ TEX | 29 | W 5-4 | 15-14 | 4 | 28,764 | Jeff Shaw | Nolan Ryan | Steve Olin | Jeff Russell | Doug Jones | 130 | 124 | 6 |
| 1990-05-12 | @ TEX | 30 | L 1-2 | 15-15 | 4 | 36,220 | Buddy Black | Bobby Witt | Bobby Witt | Buddy Black | Jeff Russell | 131 | 126 | 5 |
| 1990-05-13 | @ TEX | 31 | W 4-1 | 16-15 | 4 | 19,223 | John Farrell | Charlie Hough | John Farrell | Charlie Hough | Doug Jones | 135 | 127 | 8 |
| 1990-05-15 | vs OAK | 32 | W 5-4 | 17-15 | 4 | 8,734 | Greg Swindell | Scott Sanderson | Cecilio Guante | Rick Honeycutt | Doug Jones | 140 | 131 | 9 |
| 1990-05-16 | vs OAK | 33 | L 6-7 | 17-16 | 4 | 10,706 | Jeff Shaw | Bob Welch | Dennis Eckersley | Doug Jones | | 146 | 138 | 8 |
| 1990-05-18 | vs SEA | 34 | W 5-0 | 18-16 | 4 | 28,024 | Buddy Black | Erik Hanson | Buddy Black | Erik Hanson | | 151 | 138 | 13 |
| 1990-05-19 | vs SEA | 35 | W 4-3 | 19-16 | 3 | 15,092 | John Farrell | Matt Young | Jesse Orosco | Matt Young | Doug Jones | 155 | 141 | 14 |
| 1990-05-20 | vs SEA | 36 | L 7-8 | 19-17 | 4 | 20,242 | Greg Swindell | Scott Bankhead | Mike Schooler | Jesse Orosco | | 162 | 149 | 13 |
| 1990-05-21 | vs CAL | 37 | L 3-5 | 19-18 | 4 | 5,637 | Jeff Shaw | Bert Blyleven | Bert Blyleven | Jeff Shaw | Mark Eichhorn | 165 | 154 | 11 |
| 1990-05-22 | vs CAL | 38 | L 3-8 | 19-19 | 4 | 7,333 | Tom Candiotti | Chuck Finley | Chuck Finley | Tom Candiotti | Bryan Harvey | 168 | 162 | 6 |
| 1990-05-23 | @ SEA | 39 | L 1-4 | 19-20 | 4 | 10,207 | Buddy Black | Erik Hanson | Erik Hanson | Buddy Black | Mike Schooler | 169 | 166 | 3 |
| 1990-05-24 | @ SEA | 40 | W 5-3 | 20-20 | 3 | 10,271 | John Farrell | Matt Young | Jesse Orosco | Matt Young | Doug Jones | 174 | 169 | 5 |
| 1990-05-25 | @ OAK | 41 | L 2-5 | 20-21 | 4 | 33,622 | Greg Swindell | Scott Sanderson | Scott Sanderson | Greg Swindell | Dennis Eckersley | 176 | 174 | 2 |
| 1990-05-26 | @ OAK | 42 | L 3-6 | 20-22 | 4 | 42,783 | Sergio Valdez | Bob Welch | Bob Welch | Sergio Valdez | Dennis Eckersley | 179 | 180 | -1 |
| 1990-05-28 | @ CAL | 43 | W 3-0 | 21-22 | 4 | 26,477 | Buddy Black | Jim Abbott | Cecilio Guante | Jim Abbott | Doug Jones | 182 | 180 | 2 |
| 1990-05-29 | @ CAL | 44 | L 1-2 | 21-23 | 4 | 22,429 | John Farrell | Kirk McCaskill | Kirk McCaskill | John Farrell | Mark Eichhorn | 183 | 182 | 1 |
| 1990-05-30 | @ CAL | 45 | W 4-2 | 22-23 | 4 | 25,543 | Tom Candiotti | Mark Langston | Tom Candiotti | Mark Langston | Doug Jones | 187 | 184 | 3 |
| 1990-06-01 | vs BOS | 46 | L 3-4 | 22-24 | 4 | 23,833 | Greg Swindell | Mike Boddicker | Jerry Reed | Doug Jones | Jeff Reardon | 190 | 188 | 2 |
| 1990-06-02 | vs BOS | 47 | W 7-5 | 23-24 | 4 | 33,569 | Buddy Black | Greg Harris | Sergio Valdez | Rob Murphy | Doug Jones | 197 | 193 | 4 |
| 1990-06-03 | vs BOS | 48 | L 2-8 | 23-25 | 4 | 29,137 | John Farrell | Roger Clemens | Roger Clemens | John Farrell | | 199 | 201 | -2 |
| 1990-06-05 | vs DET | 49 | L 2-6 | 23-26 | 4 | 12,407 | Tom Candiotti | Dan Petry | Dan Petry | Tom Candiotti | Ed Nunez | 201 | 207 | -6 |
| 1990-06-06 | vs DET | 50 | L 4-6 | 23-27 | 5 | 13,213 | Greg Swindell | Jack Morris | Jack Morris | Greg Swindell | Mike Henneman | 205 | 213 | -8 |
| 1990-06-07 | vs DET | 51 | L 0-8 | 23-28 | 6 | 8,927 | Buddy Black | Brian Dubois | Brian Dubois | Buddy Black | | 205 | 221 | -16 |
| 1990-06-08 | @ BOS | 52 | L 3-4 | 23-29 | 6 | 34,222 | John Farrell | Roger Clemens | Roger Clemens | John Farrell | Jeff Reardon | 208 | 225 | -17 |
| 1990-06-09 | @ BOS | 53 | L 6-11 | 23-30 | 6 | 32,991 | Sergio Valdez | Dana Kiecker | Dana Kiecker | Sergio Valdez | Jerry Reed | 214 | 236 | -22 |
| 1990-06-10 | @ BOS | 54 | W 4-0 | 24-30 | 6 | 33,961 | Tom Candiotti | Wes Gardner | Tom Candiotti | Wes Gardner | Doug Jones | 218 | 236 | -18 |
| 1990-06-11 | @ BOS | 55 | W 4-3 | 25-30 | 6 | 30,404 | Greg Swindell | Mike Boddicker | Rudy Seanez | Dennis Lamp | Doug Jones | 222 | 239 | -17 |
| 1990-06-12 | @ DET | 56 | W 7-3 | 26-30 | 5 | 12,332 | Buddy Black | Brian Dubois | Buddy Black | Brian Dubois | | 229 | 242 | -13 |
| 1990-06-13 | @ DET | 57 | L 4-5 | 26-31 | 6 | 13,728 | John Farrell | Jeff Robinson | Mike Henneman | Rudy Seanez | | 233 | 247 | -14 |
| 1990-06-14 | @ DET | 58 | L 3-7 | 26-32 | 6 | 12,309 | Sergio Valdez | Frank Tanana | Frank Tanana | Sergio Valdez | | 236 | 254 | -18 |
| 1990-06-15 | vs MIL | 59 | W 5-3 | 27-32 | 6 | 63,546 | Tom Candiotti | Dennis Powell | Tom Candiotti | Dennis Powell | Doug Jones | 241 | 257 | -16 |
| 1990-06-16 | vs MIL | 60 | W 10-9 | 28-32 | 6 | 15,497 | Greg Swindell | Bill Krueger | Doug Jones | Bob Sebra | | 251 | 266 | -15 |
| 1990-06-17 | vs MIL | 61 | W 12-4 | 29-32 | 4 | 22,963 | Buddy Black | Ron Robinson | Buddy Black | Ron Robinson | | 263 | 270 | -7 |
| 1990-06-19 | vs BAL | 62 | W 5-4 | 30-32 | 4 | 14,416 | John Farrell | Bob Milacki | Doug Jones | Gregg Olson | | 268 | 274 | -6 |
| 1990-06-20 | vs BAL | 63 | L 1-3 | 30-33 | 4 | 8,796 | Tom Candiotti | Pete Harnisch | Pete Harnisch | Jesse Orosco | Gregg Olson | 269 | 277 | -8 |
| 1990-06-21 | vs BAL | 64 | W 4-3 | 31-33 | 3 | 12,433 | Greg Swindell | John Mitchell | Doug Jones | Brian Holton | | 273 | 280 | -7 |
| 1990-06-22 | @ MIL | 65 | L 7-9 | 31-34 | 3 | 26,420 | Buddy Black | Bill Krueger | Tom Edens | Buddy Black | Dan Plesac | 280 | 289 | -9 |
| 1990-06-23 | @ MIL | 66 | L 1-11 | 31-35 | 5 | 34,010 | Al Nipper | Ron Robinson | Ron Robinson | Al Nipper | | 281 | 300 | -19 |
| 1990-06-24 | @ MIL | 67 | W 9-5 | 32-35 | 3 | 45,749 | John Farrell | Mark Knudson | John Farrell | Mark Knudson | | 290 | 305 | -15 |
| 1990-06-25 | @ MIL | 68 | W 10-5 | 33-35 | 3 | 17,275 | Tom Candiotti | Chris Bosio | Tom Candiotti | Chris Bosio | | 300 | 310 | -10 |
| 1990-06-26 | @ BAL | 69 | W 5-3 | 34-35 | 3 | 35,093 | Greg Swindell | Pete Harnisch | Doug Jones | Pete Harnisch | | 305 | 313 | -8 |
| 1990-06-27 | @ BAL | 70 | L 3-6 | 34-36 | 3 | 29,310 | Buddy Black | John Mitchell | Gregg Olson | Sergio Valdez | | 308 | 319 | -11 |
| 1990-06-28 | @ BAL | 71 | W 7-4 | 35-36 | 3 | 33,449 | Al Nipper | Jeff Ballard | Al Nipper | Jeff Ballard | | 315 | 323 | -8 |
| 1990-06-29 | vs CAL | 72 | L 2-7 | 35-37 | 3 | 20,736 | Charles Nagy | Jim Abbott | Jim Abbott | Charles Nagy | | 317 | 330 | -13 |
| 1990-06-30 | vs CAL | 73 | W 4-1 | 36-37 | 3 | 18,930 | Tom Candiotti | Kirk McCaskill | Tom Candiotti | Kirk McCaskill | Doug Jones | 321 | 331 | -10 |
| 1990-07-01 | vs CAL | 74 | W 5-3 | 37-37 | 3 | 27,001 | Greg Swindell | Mark Langston | Greg Swindell | Mark Langston | Doug Jones | 326 | 334 | -8 |
| 1990-07-02 | vs CAL | 75 | L 1-2 | 37-38 | 3 | 12,309 | Buddy Black | Chuck Finley | Chuck Finley | Jesse Orosco | Bryan Harvey | 327 | 336 | -9 |
| 1990-07-03 | vs SEA | 76 | W 9-4 | 38-38 | 3 | 45,242 | Al Nipper | Matt Young | Al Nipper | Matt Young | | 336 | 340 | -4 |
| 1990-07-04 | vs SEA | 77 | L 2-3 | 38-39 | 3 | 14,948 | Charles Nagy | Randy Johnson | Randy Johnson | Charles Nagy | Mike Schooler | 338 | 343 | -5 |
| 1990-07-05 | vs SEA | 78 | L 1-4 | 38-40 | 3 | 12,405 | Tom Candiotti | Erik Hanson | Erik Hanson | Tom Candiotti | Mike Schooler | 339 | 347 | -8 |
| 1990-07-06 | vs OAK | 79 | W 6-1 | 39-41 | 3 | 0 | Greg Swindell | Scott Sanderson | Greg Swindell | Scott Sanderson | | 345 | 348 | -3 |
| 1990-07-06 | vs OAK | 80 | L 1-12 | 39-41 | 3 | 45,705 | Sergio Valdez | Mike Moore | Mike Moore | Sergio Valdez | | 346 | 360 | -14 |
| 1990-07-07 | vs OAK | 81 | W 1-0 | 40-41 | 3 | 49,989 | Buddy Black | Curt Young | Buddy Black | Curt Young | | 347 | 360 | -13 |
| 1990-07-08 | vs OAK | 82 | L 3-8 | 40-42 | 3 | 31,299 | Al Nipper | Dave Stewart | Dave Stewart | Al Nipper | | 350 | 368 | -18 |
| 1990-07-12 | @ SEA | 83 | W 5-4 | 41-42 | 3 | 11,291 | Greg Swindell | Brian Holman | Rudy Seanez | Mike Schooler | Doug Jones | 355 | 372 | -17 |
| 1990-07-13 | @ SEA | 84 | W 13-7 | 42-42 | 3 | 12,381 | Tom Candiotti | Matt Young | Tom Candiotti | Matt Young | | 368 | 379 | -11 |
| 1990-07-14 | @ SEA | 85 | W 3-0 | 43-42 | 3 | 17,735 | Buddy Black | Randy Johnson | Buddy Black | Randy Johnson | Doug Jones | 371 | 379 | -8 |
| 1990-07-15 | @ SEA | 86 | L 0-7 | 43-43 | 3 | 12,597 | Charles Nagy | Bill Swift | Bill Swift | Charles Nagy | | 371 | 386 | -15 |
| 1990-07-16 | @ OAK | 87 | L 0-3 | 43-44 | 3 | 28,079 | Al Nipper | Scott Sanderson | Scott Sanderson | Al Nipper | Gene Nelson | 371 | 389 | -18 |
| 1990-07-17 | @ OAK | 88 | W 4-2 | 44-44 | 3 | 26,811 | Greg Swindell | Mike Moore | Greg Swindell | Mike Moore | Doug Jones | 375 | 391 | -16 |
| 1990-07-18 | @ OAK | 89 | L 1-4 | 44-46 | 3 | 0 | Tom Candiotti | Bob Welch | Bob Welch | Tom Candiotti | Dennis Eckersley | 376 | 395 | -19 |
| 1990-07-18 | @ OAK | 90 | L 2-5 | 44-46 | 3 | 38,958 | Rod Nichols | Dave Stewart | Dave Stewart | Rod Nichols | Dennis Eckersley | 378 | 400 | -22 |
| 1990-07-20 | @ CAL | 91 | L 4-9 | 44-47 | 3 | 32,254 | Buddy Black | Bert Blyleven | Bert Blyleven | Buddy Black | Mike Fetters | 382 | 409 | -27 |
| 1990-07-21 | @ CAL | 92 | L 2-5 | 44-48 | 4 | 32,761 | Mike Walker | Chuck Finley | Chuck Finley | Mike Walker | | 384 | 414 | -30 |
| 1990-07-22 | @ CAL | 93 | W 8-1 | 45-48 | 4 | 32,126 | Greg Swindell | Mark Langston | Greg Swindell | Mark Langston | | 392 | 415 | -23 |
| 1990-07-23 | @ CHA | 94 | L 1-3 | 45-49 | 4 | 30,534 | Tom Candiotti | Greg Hibbard | Greg Hibbard | Tom Candiotti | Bobby Thigpen | 393 | 418 | -25 |
| 1990-07-24 | @ CHA | 95 | L 3-8 | 45-50 | 4 | 37,095 | Rod Nichols | Adam Peterson | Adam Peterson | Rod Nichols | Donn Pall | 396 | 426 | -30 |
| 1990-07-25 | @ CHA | 96 | W 6-1 | 46-50 | 4 | 31,776 | Buddy Black | Eric King | Buddy Black | Eric King | | 402 | 427 | -25 |
| 1990-07-27 | vs NYA | 97 | L 0-3 | 46-52 | 5 | 0 | Greg Swindell | Andy Hawkins | Andy Hawkins | Greg Swindell | | 402 | 430 | -28 |
| 1990-07-27 | vs NYA | 98 | L 1-4 | 46-52 | 5 | 44,510 | Mike Walker | Jeff Robinson | Jeff Robinson | Mike Walker | Dave Righetti | 403 | 434 | -31 |
| 1990-07-28 | vs NYA | 99 | W 2-1 | 47-52 | 5 | 28,387 | Tom Candiotti | Chuck Cary | Tom Candiotti | Chuck Cary | Doug Jones | 405 | 435 | -30 |
| 1990-07-29 | vs NYA | 100 | L 5-8 | 47-54 | 5 | 0 | Buddy Black | Tim Leary | Tim Leary | Buddy Black | Greg Cadaret | 410 | 443 | -33 |
| 1990-07-29 | vs NYA | 101 | L 3-4 | 47-54 | 5 | 32,656 | Cecilio Guante | Jimmy Jones | Eric Plunk | Cecilio Guante | Greg Cadaret | 413 | 447 | -34 |
| 1990-07-30 | vs KCA | 102 | L 6-7 | 47-55 | 5 | 14,053 | Jeff Shaw | Andy McGaffigan | Andy McGaffigan | Jeff Shaw | Jeff Montgomery | 419 | 454 | -35 |
| 1990-07-31 | vs KCA | 103 | L 4-8 | 47-56 | 5 | 20,251 | Mike Walker | Kevin Appier | Kevin Appier | Mike Walker | | 423 | 462 | -39 |
| 1990-08-01 | vs KCA | 104 | W 4-1 | 48-56 | 5 | 12,804 | Greg Swindell | Mark Davis | Greg Swindell | Mark Davis | Doug Jones | 427 | 463 | -36 |
| 1990-08-03 | @ NYA | 105 | L 4-6 | 48-57 | 5 | 27,945 | Tom Candiotti | Chuck Cary | Lee Guetterman | Tom Candiotti | | 431 | 469 | -38 |
| 1990-08-04 | @ NYA | 106 | W 17-3 | 49-57 | 5 | 24,550 | Buddy Black | Tim Leary | Buddy Black | Tim Leary | | 448 | 472 | -24 |
| 1990-08-05 | @ NYA | 107 | L 3-5 | 49-58 | 5 | 34,488 | Mike Walker | Dave LaPoint | Greg Cadaret | Steve Olin | | 451 | 477 | -26 |
| 1990-08-06 | @ NYA | 108 | L 1-2 | 49-59 | 5 | 22,205 | Greg Swindell | Andy Hawkins | Andy Hawkins | Greg Swindell | Dave Righetti | 452 | 479 | -27 |
| 1990-08-07 | vs TEX | 109 | W 8-4 | 50-59 | 5 | 11,217 | Tom Candiotti | Kevin Brown | Colby Ward | Kevin Brown | | 460 | 483 | -23 |
| 1990-08-08 | vs TEX | 110 | W 5-3 | 51-59 | 5 | 10,019 | Jeff Shaw | Jamie Moyer | Jeff Shaw | Jamie Moyer | Doug Jones | 465 | 486 | -21 |
| 1990-08-09 | vs TEX | 111 | L 5-13 | 51-60 | 5 | 9,726 | Buddy Black | Bobby Witt | Bobby Witt | Buddy Black | | 470 | 499 | -29 |
| 1990-08-10 | vs DET | 112 | W 5-2 | 52-60 | 5 | 42,196 | Mike Walker | Steve Searcy | Mike Walker | Steve Searcy | Doug Jones | 475 | 501 | -26 |
| 1990-08-11 | vs DET | 113 | W 13-4 | 53-60 | 4 | 15,319 | Greg Swindell | Dan Petry | Greg Swindell | Dan Petry | Colby Ward | 488 | 505 | -17 |
| 1990-08-12 | vs DET | 114 | W 9-5 | 54-60 | 4 | 24,484 | Tom Candiotti | Jack Morris | Tom Candiotti | Jack Morris | Doug Jones | 497 | 510 | -13 |
| 1990-08-13 | vs DET | 115 | L 5-6 | 54-61 | 4 | 12,073 | Jeff Shaw | Walt Terrell | Walt Terrell | Jeff Shaw | Jerry Gleaton | 502 | 516 | -14 |
| 1990-08-14 | vs MIN | 116 | L 4-5 | 54-62 | 4 | 11,270 | Buddy Black | Mark Guthrie | Mark Guthrie | Buddy Black | Rick Aguilera | 506 | 521 | -15 |
| 1990-08-15 | vs MIN | 117 | W 5-4 | 55-62 | 4 | 10,917 | Mike Walker | David West | Jesse Orosco | Tim Drummond | Doug Jones | 511 | 525 | -14 |
| 1990-08-16 | vs MIN | 118 | W 7-5 | 56-62 | 4 | 11,085 | Greg Swindell | Kevin Tapani | Greg Swindell | Kevin Tapani | Doug Jones | 518 | 530 | -12 |
| 1990-08-17 | @ DET | 119 | L 0-3 | 56-63 | 4 | 21,286 | Tom Candiotti | Jack Morris | Jack Morris | Tom Candiotti | | 518 | 533 | -15 |
| 1990-08-18 | @ DET | 120 | L 3-6 | 56-64 | 4 | 25,808 | Jeff Shaw | Walt Terrell | Walt Terrell | Jeff Shaw | Ed Nunez | 521 | 539 | -18 |
| 1990-08-20 | @ MIL | 121 | L 3-4 | 56-65 | 4 | 11,427 | Buddy Black | Tom Edens | Tom Edens | Steve Olin | Chuck Crim | 524 | 543 | -19 |
| 1990-08-21 | @ MIL | 122 | L 5-6 | 56-66 | 5 | 19,162 | Greg Swindell | Ron Robinson | Dan Plesac | Colby Ward | | 529 | 549 | -20 |
| 1990-08-22 | @ MIL | 123 | W 4-2 | 57-66 | 5 | 20,547 | Tom Candiotti | Teddy Higuera | Tom Candiotti | Teddy Higuera | Doug Jones | 533 | 551 | -18 |
| 1990-08-24 | @ BAL | 124 | L 4-5 | 57-67 | 5 | 32,053 | Mike Walker | Anthony Telford | Joe Price | Colby Ward | | 537 | 556 | -19 |
| 1990-08-25 | @ BAL | 125 | W 11-5 | 58-67 | 5 | 34,163 | Sergio Valdez | Pete Harnisch | Steve Olin | Pete Harnisch | | 548 | 561 | -13 |
| 1990-08-26 | @ BAL | 126 | W 8-3 | 59-67 | 5 | 33,716 | Greg Swindell | John Mitchell | Greg Swindell | Joe Price | | 556 | 564 | -8 |
| 1990-08-27 | vs BOS | 127 | L 4-12 | 59-68 | 5 | 10,411 | Tom Candiotti | Mike Boddicker | Mike Boddicker | Tom Candiotti | | 560 | 576 | -16 |
| 1990-08-28 | vs BOS | 128 | L 5-6 | 59-69 | 6 | 10,799 | Charles Nagy | Tom Bolton | Wes Gardner | Doug Jones | Jeff Gray | 565 | 582 | -17 |
| 1990-08-29 | vs BOS | 129 | L 1-7 | 59-70 | 6 | 8,862 | Mike Walker | Dana Kiecker | Dana Kiecker | Mike Walker | | 566 | 589 | -23 |
| 1990-08-30 | vs BOS | 130 | L 2-9 | 59-71 | 6 | 9,651 | Sergio Valdez | Roger Clemens | Roger Clemens | Doug Jones | | 568 | 598 | -30 |
| 1990-08-31 | vs TOR | 131 | L 8-12 | 59-72 | 6 | 12,508 | Greg Swindell | David Wells | Jim Acker | Greg Swindell | | 576 | 610 | -34 |
| 1990-09-01 | vs TOR | 132 | L 0-8 | 59-73 | 6 | 16,547 | Tom Candiotti | Todd Stottlemyre | Todd Stottlemyre | Tom Candiotti | | 576 | 618 | -42 |
| 1990-09-02 | vs TOR | 133 | L 0-3 | 59-74 | 6 | 23,640 | Buddy Black | Dave Stieb | Dave Stieb | Buddy Black | | 576 | 621 | -45 |
| 1990-09-03 | @ TEX | 134 | L 2-6 | 59-75 | 6 | 14,154 | Mike Walker | Nolan Ryan | Nolan Ryan | Mike Walker | | 578 | 627 | -49 |
| 1990-09-04 | @ TEX | 135 | W 7-5 | 60-75 | 6 | 10,467 | Sergio Valdez | Kevin Brown | Sergio Valdez | Kevin Brown | | 585 | 632 | -47 |
| 1990-09-05 | @ TEX | 136 | L 2-3 | 60-76 | 6 | 10,969 | Greg Swindell | Scott Chiamparino | Kenny Rogers | Doug Jones | | 587 | 635 | -48 |
| 1990-09-06 | @ DET | 137 | W 6-0 | 61-76 | 5 | 11,283 | Tom Candiotti | Randy Nosek | Tom Candiotti | Randy Nosek | | 593 | 635 | -42 |
| 1990-09-07 | @ MIN | 138 | L 0-2 | 61-77 | 6 | 18,696 | Buddy Black | Allan Anderson | Allan Anderson | Buddy Black | Rick Aguilera | 593 | 637 | -44 |
| 1990-09-08 | @ MIN | 139 | L 1-6 | 61-78 | 6 | 17,394 | Mike Walker | Scott Erickson | Scott Erickson | Mike Walker | | 594 | 643 | -49 |
| 1990-09-09 | @ MIN | 140 | W 12-9 | 62-78 | 6 | 14,414 | Sergio Valdez | Mark Guthrie | Steve Olin | Jack Savage | | 606 | 652 | -46 |
| 1990-09-10 | vs CHA | 141 | W 3-2 | 63-79 | 6 | 0 | Greg Swindell | Greg Hibbard | Doug Jones | Barry Jones | | 609 | 654 | -45 |
| 1990-09-10 | vs CHA | 142 | L 2-6 | 63-79 | 6 | 4,781 | Charles Nagy | Eric King | Eric King | Charles Nagy | Bobby Thigpen | 611 | 660 | -49 |
| 1990-09-11 | vs CHA | 143 | W 4-3 | 64-79 | 6 | 4,903 | Tom Candiotti | Wayne Edwards | Jesse Orosco | Barry Jones | | 615 | 663 | -48 |
| 1990-09-12 | vs CHA | 144 | W 12-2 | 65-79 | 6 | 4,705 | Buddy Black | Melido Perez | Buddy Black | Melido Perez | | 627 | 665 | -38 |
| 1990-09-14 | @ KCA | 145 | W 6-4 | 66-79 | 5 | 22,108 | Sergio Valdez | Kevin Appier | Sergio Valdez | Kevin Appier | Doug Jones | 633 | 669 | -36 |
| 1990-09-15 | @ KCA | 146 | W 14-6 | 67-79 | 5 | 31,867 | Greg Swindell | Andy McGaffigan | Greg Swindell | Andy McGaffigan | Steve Olin | 647 | 675 | -28 |
| 1990-09-16 | @ KCA | 147 | L 6-9 | 67-80 | 5 | 23,806 | Mike Walker | Hector Wagner | Jeff Montgomery | Efrain Valdez | | 653 | 684 | -31 |
| 1990-09-17 | vs MIL | 148 | W 4-2 | 68-80 | 5 | 3,972 | Steve Olin | Teddy Higuera | Steve Olin | Teddy Higuera | Doug Jones | 657 | 686 | -29 |
| 1990-09-18 | vs MIL | 149 | W 8-3 | 69-80 | 5 | 4,082 | Charles Nagy | Bill Krueger | Charles Nagy | Don August | Doug Jones | 665 | 689 | -24 |
| 1990-09-19 | vs MIL | 150 | W 6-3 | 70-80 | 4 | 4,169 | Sergio Valdez | Jaime Navarro | Sergio Valdez | Jaime Navarro | Doug Jones | 671 | 692 | -21 |
| 1990-09-20 | @ NYA | 151 | W 12-7 | 71-80 | 4 | 18,058 | Greg Swindell | Dave Eiland | Mike Walker | Rich Monteleone | | 683 | 699 | -16 |
| 1990-09-21 | @ TOR | 152 | W 2-1 | 72-80 | 4 | 49,894 | John Farrell | David Wells | Efrain Valdez | Frank Wills | Doug Jones | 685 | 700 | -15 |
| 1990-09-22 | @ TOR | 153 | W 5-2 | 73-80 | 4 | 49,883 | Jeff Shaw | Todd Stottlemyre | Jeff Shaw | Todd Stottlemyre | Doug Jones | 690 | 702 | -12 |
| 1990-09-23 | @ TOR | 154 | L 4-5 | 73-81 | 4 | 49,901 | Charles Nagy | Dave Stieb | Jim Acker | Colby Ward | | 694 | 707 | -13 |
| 1990-09-25 | @ BOS | 155 | W 5-2 | 74-81 | 4 | 28,670 | Greg Swindell | Greg Harris | Greg Swindell | Greg Harris | Doug Jones | 699 | 709 | -10 |
| 1990-09-26 | @ BOS | 156 | L 2-7 | 74-82 | 4 | 28,824 | Tom Candiotti | Dana Kiecker | Dana Kiecker | Tom Candiotti | | 701 | 716 | -15 |
| 1990-09-27 | vs BAL | 157 | L 3-5 | 74-83 | 4 | 4,794 | John Farrell | Dave Johnson | Dave Johnson | John Farrell | Gregg Olson | 704 | 721 | -17 |
| 1990-09-28 | vs BAL | 158 | L 0-2 | 74-84 | 4 | 8,641 | Sergio Valdez | Ben McDonald | Ben McDonald | Sergio Valdez | | 704 | 723 | -19 |
| 1990-09-30 | vs BAL | 159 | L 3-6 | 75-85 | 4 | 0 | Greg Swindell | Bob Milacki | Bob Milacki | Greg Swindell | Gregg Olson | 707 | 729 | -22 |
| 1990-09-30 | vs BAL | 160 | W 7-3 | 75-85 | 4 | 14,049 | Charles Nagy | Danny Boone | Charles Nagy | Dorn Taylor | Doug Jones | 714 | 732 | -18 |
| 1990-10-02 | vs KCA | 161 | W 13-3 | 76-85 | 4 | 4,709 | Tom Candiotti | Hector Wagner | Tom Candiotti | Hector Wagner | | 727 | 735 | -8 |
| 1990-10-03 | vs KCA | 162 | W 5-2 | 77-85 | 4 | 5,196 | Sergio Valdez | Dar Smith | Sergio Valdez | Dar Smith | Doug Jones | 732 | 737 | -5 |